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Volumn 30, Issue 6, 2012, Pages 333-341

Trimetazidine Reduces Endogenous Free Fatty Acid Oxidation and Improves Myocardial Efficiency in Obese Humans

Author keywords

Fatty acid oxidation; Imaging; Myocardial metabolism; Obesity; Triglyceride turnover; Trimetazidine

Indexed keywords

FATTY ACID; FLUORODEOXYGLUCOSE F 18; GLUCOSE; PALMITIC ACID C 11; TRIACYLGLYCEROL; TRIMETAZIDINE;

EID: 84869081812     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2011.00275.x     Document Type: Article
Times cited : (41)

References (47)
  • 1
    • 0034678082 scopus 로고    scopus 로고
    • The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
    • Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res 2000;86:580-588.
    • (2000) Circ Res , vol.86 , pp. 580-588
    • Kantor, P.F.1    Lucien, A.2    Kozak, R.3    Lopaschuk, G.D.4
  • 2
    • 0141499890 scopus 로고    scopus 로고
    • Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase
    • Lopaschuk GD, Barr R, Thomas PD, Dyck JR. Beneficial effects of trimetazidine in ex vivo working ischemic hearts are due to a stimulation of glucose oxidation secondary to inhibition of long-chain 3-ketoacyl coenzyme a thiolase. Circ Res 2003;93:e33-e37.
    • (2003) Circ Res , vol.93
    • Lopaschuk, G.D.1    Barr, R.2    Thomas, P.D.3    Dyck, J.R.4
  • 3
    • 53449101397 scopus 로고    scopus 로고
    • Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
    • Tuunanen H, Engblom E, Naum A, et al. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation 2008;118:1250-1258.
    • (2008) Circulation , vol.118 , pp. 1250-1258
    • Tuunanen, H.1    Engblom, E.2    Naum, A.3
  • 4
    • 0020533259 scopus 로고
    • Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study
    • Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983;67:968-977.
    • (1983) Circulation , vol.67 , pp. 968-977
    • Hubert, H.B.1    Feinleib, M.2    McNamara, P.M.3    Castelli, W.P.4
  • 5
    • 0036681988 scopus 로고    scopus 로고
    • Obesity and the risk of heart failure
    • Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med 2002;347:305-313.
    • (2002) N Engl J Med , vol.347 , pp. 305-313
    • Kenchaiah, S.1    Evans, J.C.2    Levy, D.3
  • 6
    • 57249094367 scopus 로고    scopus 로고
    • Cardiovascular consequences of obesity and targets for treatment
    • Mittendorfer B, Peterson LR. Cardiovascular consequences of obesity and targets for treatment. Drug Discov Today Ther Strateg 2008;5:53-61.
    • (2008) Drug Discov Today Ther Strateg , vol.5 , pp. 53-61
    • Mittendorfer, B.1    Peterson, L.R.2
  • 7
    • 33751546348 scopus 로고    scopus 로고
    • Myocardial triglyceride content and epicardial fat mass in human obesity: Relationship to left ventricular function and serum free fatty acid levels
    • Kankaanpaa M, Lehto HR, Parkka JP, et al. Myocardial triglyceride content and epicardial fat mass in human obesity: Relationship to left ventricular function and serum free fatty acid levels. J Clin Endocrinol Metab 2006;91:4689-4695.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4689-4695
    • Kankaanpaa, M.1    Lehto, H.R.2    Parkka, J.P.3
  • 8
    • 55949119360 scopus 로고    scopus 로고
    • Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
    • Rijzewijk LJ, Van Der Meer RW, Smit JW, et al. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. J Am Coll Cardiol 2008;52:1793-1799.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1793-1799
    • Rijzewijk, L.J.1    Van Der Meer, R.W.2    Smit, J.W.3
  • 9
    • 2442492971 scopus 로고    scopus 로고
    • Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women
    • Peterson LR, Herrero P, Schechtman KB, et al. Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 2004;109:2191-2196.
    • (2004) Circulation , vol.109 , pp. 2191-2196
    • Peterson, L.R.1    Herrero, P.2    Schechtman, K.B.3
  • 11
    • 0027375098 scopus 로고
    • Estimation of metabolite concentrations from localized in vivo proton NMR spectra
    • Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679.
    • (1993) Magn Reson Med , vol.30 , pp. 672-679
    • Provencher, S.W.1
  • 12
    • 33745186040 scopus 로고    scopus 로고
    • Comparison of the phospholipid and triacylglycerol fatty acid profile of rat serum, skeletal muscle and heart
    • Nikolaidis MG, Petridou A, Mougios V. Comparison of the phospholipid and triacylglycerol fatty acid profile of rat serum, skeletal muscle and heart. Physiol Res 2006;55:259-265.
    • (2006) Physiol Res , vol.55 , pp. 259-265
    • Nikolaidis, M.G.1    Petridou, A.2    Mougios, V.3
  • 13
    • 0033007207 scopus 로고    scopus 로고
    • Measurement of intracellular triglyceride stores by H spectroscopy: Validation in vivo
    • Szczepaniak LS, Babcock EE, Schick F, et al. Measurement of intracellular triglyceride stores by H spectroscopy: Validation in vivo. Am J Physiol 1999;276:E977-E989.
    • (1999) Am J Physiol , vol.276
    • Szczepaniak, L.S.1    Babcock, E.E.2    Schick, F.3
  • 14
    • 3743088905 scopus 로고
    • The water and electrolyte content of the human heart in congestive heart failure with and without digitalization
    • Clarke NE, Mosher RE. The water and electrolyte content of the human heart in congestive heart failure with and without digitalization. Circulation 1952;5:907-914.
    • (1952) Circulation , vol.5 , pp. 907-914
    • Clarke, N.E.1    Mosher, R.E.2
  • 16
    • 36848999820 scopus 로고    scopus 로고
    • Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects
    • van der Meer RW, Hammer S, Smit JW, et al. Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects. Diabetes 2007;56:2849-2853.
    • (2007) Diabetes , vol.56 , pp. 2849-2853
    • van der Meer, R.W.1    Hammer, S.2    Smit, J.W.3
  • 17
    • 0022885139 scopus 로고
    • Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution
    • Hamacher K, Coenen HH, Stocklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med 1986;27:235-238.
    • (1986) J Nucl Med , vol.27 , pp. 235-238
    • Hamacher, K.1    Coenen, H.H.2    Stocklin, G.3
  • 18
    • 0020281754 scopus 로고
    • [1-(11)C]palmitic acid: Improved radiopharmaceutical preparation
    • Padgett HC, Robinson GD, Barrio JR. [1-(11)C]palmitic acid: Improved radiopharmaceutical preparation. Int J Appl Radiat Isot 1982;33:1471-1472.
    • (1982) Int J Appl Radiat Isot , vol.33 , pp. 1471-1472
    • Padgett, H.C.1    Robinson, G.D.2    Barrio, J.R.3
  • 19
    • 33646572502 scopus 로고    scopus 로고
    • 11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia
    • 11C]palmitate kinetics across the splanchnic bed in arterial, portal and hepatic venous plasma during fasting and euglycemic hyperinsulinemia. Nucl Med Biol 2006;33:521-528.
    • (2006) Nucl Med Biol , vol.33 , pp. 521-528
    • Guiducci, L.1    Jarvisalo, M.2    Kiss, J.3
  • 23
    • 0020422441 scopus 로고
    • C- 11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. II. Kinetics of C- 11 palmitic acid in acutely ischemic myocardium
    • Schon HR, Schelbert HR, Najafi A, Hansen H, Huang H, Barrio J, Phelps ME. C- 11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. II. Kinetics of C- 11 palmitic acid in acutely ischemic myocardium. Am Heart J 1982;103:548-561.
    • (1982) Am Heart J , vol.103 , pp. 548-561
    • Schon, H.R.1    Schelbert, H.R.2    Najafi, A.3    Hansen, H.4    Huang, H.5    Barrio, J.6    Phelps, M.E.7
  • 27
    • 0020417226 scopus 로고
    • Main features of computer algorithms for RIA data reduction; comparison of some different approaches for the interpolation of the dose-response curve
    • Pilo A, Zucchelli GC, Malvano R, Masini S. Main features of computer algorithms for RIA data reduction; comparison of some different approaches for the interpolation of the dose-response curve. J Nucl Med Allied Sci 1982;26:235-248.
    • (1982) J Nucl Med Allied Sci , vol.26 , pp. 235-248
    • Pilo, A.1    Zucchelli, G.C.2    Malvano, R.3    Masini, S.4
  • 29
    • 33746640458 scopus 로고    scopus 로고
    • Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes
    • Boudina S, Abel ED. Mitochondrial uncoupling: A key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda) 2006;21:250-258.
    • (2006) Physiology (Bethesda) , vol.21 , pp. 250-258
    • Boudina, S.1    Abel, E.D.2
  • 30
    • 50949116173 scopus 로고    scopus 로고
    • Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function
    • Hammer S, Snel M, Lamb HJ, et al. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. J Am Coll Cardiol 2008;52:1006-1012.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1006-1012
    • Hammer, S.1    Snel, M.2    Lamb, H.J.3
  • 31
    • 50949099173 scopus 로고    scopus 로고
    • Virchow's metamorphosis revealed triglycerides in the heart
    • Taegtmeyer H, Harmancey R. Virchow's metamorphosis revealed triglycerides in the heart. J Am Coll Cardiol 2008;52:1013-1014.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1013-1014
    • Taegtmeyer, H.1    Harmancey, R.2
  • 32
    • 1542496389 scopus 로고    scopus 로고
    • Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy
    • Fragasso G, Piatti Md PM, Monti L, et al. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am Heart J 2003;146:E18.
    • (2003) Am Heart J , vol.146
    • Fragasso, G.1    Piatti Md, P.M.2    Monti, L.3
  • 33
    • 0030720047 scopus 로고    scopus 로고
    • Trimetazidine increases phospholipid turnover in ventricular myocyte
    • Sentex E, Sergiel JP, Lucien A, Grynberg A. Trimetazidine increases phospholipid turnover in ventricular myocyte. Mol Cell Biochem 1997;175:153-162.
    • (1997) Mol Cell Biochem , vol.175 , pp. 153-162
    • Sentex, E.1    Sergiel, J.P.2    Lucien, A.3    Grynberg, A.4
  • 36
    • 64249101080 scopus 로고    scopus 로고
    • Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates
    • Luiken JJ, Niessen HE, Coort SL, et al. Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates. Biochem J 2009;419:447-455.
    • (2009) Biochem J , vol.419 , pp. 447-455
    • Luiken, J.J.1    Niessen, H.E.2    Coort, S.L.3
  • 37
    • 70349658838 scopus 로고    scopus 로고
    • The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo
    • Schwarzer M, Faerber G, Rueckauer T, Blum D, Pytel G, Mohr FW, Doenst T. The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo. Basic Res Cardiol 2009;104:547-557.
    • (2009) Basic Res Cardiol , vol.104 , pp. 547-557
    • Schwarzer, M.1    Faerber, G.2    Rueckauer, T.3    Blum, D.4    Pytel, G.5    Mohr, F.W.6    Doenst, T.7
  • 38
    • 0142060197 scopus 로고    scopus 로고
    • Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy
    • Cabrero A, Merlos M, Laguna JC, Carrera MV. Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy. J Lipid Res 2003;44:388-398.
    • (2003) J Lipid Res , vol.44 , pp. 388-398
    • Cabrero, A.1    Merlos, M.2    Laguna, J.C.3    Carrera, M.V.4
  • 39
    • 0029587279 scopus 로고
    • Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyl transferase inhibitor Etomoxir
    • Schmitz FJ, Rosen P, Reinauer H. Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyl transferase inhibitor Etomoxir. Horm Metab Res 1995;27:515-522.
    • (1995) Horm Metab Res , vol.27 , pp. 515-522
    • Schmitz, F.J.1    Rosen, P.2    Reinauer, H.3
  • 40
    • 0035996062 scopus 로고    scopus 로고
    • Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically
    • Merrill CL, Ni H, Yoon LW, et al. Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemically. Toxicol Sci 2002;68:93-101.
    • (2002) Toxicol Sci , vol.68 , pp. 93-101
    • Merrill, C.L.1    Ni, H.2    Yoon, L.W.3
  • 41
    • 34547800233 scopus 로고    scopus 로고
    • A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: The ERGO (etomoxir for the recovery of glucose oxidation) study
    • Holubarsch CJ, Rohrbach M, Karrasch M, Boehm E, Polonski L, Ponikowski P, Rhein S. A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: The ERGO (etomoxir for the recovery of glucose oxidation) study. Clin Sci (Lond) 2007;113:205-212.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 205-212
    • Holubarsch, C.J.1    Rohrbach, M.2    Karrasch, M.3    Boehm, E.4    Polonski, L.5    Ponikowski, P.6    Rhein, S.7
  • 42
    • 0022508927 scopus 로고
    • Perhexiline-induced lipidosis in the dark Agouti (DA) rat. An animal model of genetically determined neurotoxicity
    • Meier C, Wahllaender A, Hess CW, Preisig R. Perhexiline-induced lipidosis in the dark Agouti (DA) rat. An animal model of genetically determined neurotoxicity. Brain 1986;109(Pt 4):649-660.
    • (1986) Brain , vol.109 , Issue.PART 4 , pp. 649-660
    • Meier, C.1    Wahllaender, A.2    Hess, C.W.3    Preisig, R.4
  • 43
    • 0007619884 scopus 로고    scopus 로고
    • Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease
    • Killalea SM, Krum H. Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease. Am J Cardiovasc Drugs 2001;1:193-204.
    • (2001) Am J Cardiovasc Drugs , vol.1 , pp. 193-204
    • Killalea, S.M.1    Krum, H.2
  • 44
    • 0030032681 scopus 로고    scopus 로고
    • Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts
    • McCormack JG, Barr RL, Wolff AA, Lopaschuk GD. Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation 1996;93:135-142.
    • (1996) Circulation , vol.93 , pp. 135-142
    • McCormack, J.G.1    Barr, R.L.2    Wolff, A.A.3    Lopaschuk, G.D.4
  • 45
    • 0029996458 scopus 로고    scopus 로고
    • Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: Evidence for an indirect mechanism
    • Clarke B, Wyatt KM, McCormack JG. Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: Evidence for an indirect mechanism. J Mol Cell Cardiol 1996;28:341-350.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 341-350
    • Clarke, B.1    Wyatt, K.M.2    McCormack, J.G.3
  • 46
    • 33947431938 scopus 로고    scopus 로고
    • A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion
    • Wang P, Fraser H, Lloyd SG, McVeigh JJ, Belardinelli L, Chatham JC. A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion. J Pharmacol Exp Ther 2007;321:213-220.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 213-220
    • Wang, P.1    Fraser, H.2    Lloyd, S.G.3    McVeigh, J.J.4    Belardinelli, L.5    Chatham, J.C.6
  • 47
    • 77956541149 scopus 로고    scopus 로고
    • Ranolazine and its anti-ischemic effects: Revisiting an old mechanistic paradigm anew?
    • Boden WE. Ranolazine and its anti-ischemic effects: Revisiting an old mechanistic paradigm anew?J Am Coll Cardiol 2010;56:943-945.
    • (2010) J Am Coll Cardiol , vol.56 , pp. 943-945
    • Boden, W.E.1


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