Effects of weight loss on myocardial energetics and diastolic function in obesity

International Journal of Cardiovascular Imaging

Volumn 29, Issue 5, 2013, Pages 1043-1050

  Rider, O J ^a   Francis, J M ^a   Tyler, D ^a   Byrne, J ^b   Clarke, K ^a   Neubauer, S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

31P magnetic resonance spectroscopy; Diastole; Obesity; Weight loss

Indexed keywords

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLE; DIASTOLIC DYSFUNCTION; FEMALE; HEART FUNCTION; HEART LEFT VENTRICLE FILLING; HIGH ENERGY PHOSPHATE; HUMAN; MALE; MYOCARDIAL ENERGETICS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PHOSPHATE METABOLISM; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; WEIGHT REDUCTION;

ADENOSINE TRIPHOSPHATE; ADIPOSITY; ADULT; BODY MASS INDEX; DIASTOLE; ENERGY METABOLISM; HUMANS; MAGNETIC RESONANCE IMAGING, CINE; MAGNETIC RESONANCE SPECTROSCOPY; MIDDLE AGED; MYOCARDIUM; OBESITY; PHOSPHOCREATINE; RECOVERY OF FUNCTION; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT; WEIGHT LOSS;

EID: 84893662844     PISSN: 15695794     EISSN: 15730743     Source Type: Journal    
DOI: 10.1007/s10554-012-0174-6     Document Type: Article

References (33)

1. Neubauer S (2007) The failing heart - an engine out of fuel. N Engl J Med 356(11):1140-1151
2. Ashrafian H, Frenneaux MP, Opie LH (2007) Metabolic mechanisms in heart failure. Circulation 116(4):434-448. doi: 10.1161/CIRCULATIONAHA.107.702795
3. Opie LH (1971) Substrate utilization and glycolysis in the heart. Cardiology 56(1):2-21
4. Varma N, Eberli FR, Apstein CS (2000) Increased diastolic chamber stiffness during demand ischemia: response to quick length change differentiates rigor-activated from calcium-activated tension. Circulation 101(18):2185-2192
5. Diamant M, Lamb HJ, Groeneveld Y, Endert EL, Smit JW, Bax JJ, Romijn JA, de Roos A, Radder JK (2003) Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol 42(2):328-335
6. Grossman W, Momomura SI, Ingwall JS (1987) Diastolic relaxation abnormalities during ischaemia and their association with high energy phosphate depletion, intracellular pH and myocardial blood flow. Basic Res Cardiol 82(Suppl 2):289-299
7. Lamb HJ, Beyerbacht HP, van der Laarse A, Stoel BC, Doornbos J, van der Wall EE, de Roos A (1999) Diastolic dysfunction in hypertensive heart disease is associated with altered myocardial metabolism. Circulation 99(17):2261-2267
8. Neubauer S, Horn M, Cramer M, Harre K, Newell JB, Peters W, Pabst T, Ertl G, Hahn D, Ingwall JS, KochsiekK(1997) Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 96(7):2190-2196
9. Rider OJ, Francis JM, Ali MK, Holloway C, Pegg T, Robson MD, Tyler D, Byrne J, Clarke K, Neubauer S (2012) Effects of catecholamine stress on diastolic function and myocardial energetics in obesity. Circulation 125(12):1511-1519. doi:10.1161/CIRCULATIONAHA.111.069518
10. Otto ME, Belohlavek M, Khandheria B, Gilman G, Svatikova A, Somers V (2004) Comparison of right and left ventricular function in obese and nonobese men. Am J Cardiol 93(12):1569-1572
11. Peterson LR, Waggoner AD, Schechtman KB, Meyer T, Gropler RJ, Barzilai B, Davila-Roman VG (2004) Alterations in left ventricular structure and function in young healthy obese women: assessment by echocardiography and tissue Doppler imaging. J Am Coll Cardiol 43(8):1399-1404
12. Rider OJ, Francis JM, Ali MK, Petersen SE, Robinson M, Robson MD, Byrne JP, Clarke K, Neubauer S (2009) Beneficial cardiovascular effects of bariatric surgical and dietary weight loss in obesity. J Am Coll Cardiol 54(8):718-726. doi:10.1016/j.jacc.2009.02.086
13. Bhatia RS, Tu JV, Lee DS, Austin PC, Fang J, Haouzi A, Gong Y, Liu PP (2006) Outcome of heart failure with preserved ejection fraction in a population-based study. N Engl J Med 355(3): 260-269
14. Aljaroudi W, Alraies MC, Halley C, Rodriguez L, Grimm RA, Thomas JD, Jaber WA (2012) Impact of progression of diastolic dysfunction on mortality in patients with normal ejection fraction. Circulation 125(6):782-788. doi:10.1161/CIRCULATIONAHA.111.066423
15. Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC (2007) Longterm mortality after gastric bypass surgery. N Engl J Med 357(8):753-761. doi:10.1056/NEJMoa066603
16. Peterson LR, Herrero P, Schechtman KB, Racette SB, Waggoner AD, Kisrieva-Ware Z, Dence C, Klein S, Marsala J, Meyer T, Gropler RJ (2004) Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109(18):2191-2196
17. LambHJ, Beyerbacht HP,OuwerkerkR, Doornbos J, PluimBM, van derWall EE, van der Laarse A, de Roos A (1997) Metabolic response of normal human myocardium to high-dose atropine-dobutamine stress studied by 31P-MRS. Circulation 96(9):2969-2977
18. Pluim BM, Lamb HJ, Kayser HW, Leujes F, Beyerbacht HP, ZwindermanAH, van derLaarseA,VliegenHW, deRoosA, van der Wall EE (1998) Functional andmetabolic evaluation of the athlete's heart by magnetic resonance imaging and dobutamine stress magnetic resonance spectroscopy. Circulation 97(7):666-672
19. Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED (2007) Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 56(10):2457-2466
20. Hudsmith LE, Tyler DJ, Emmanuel Y, Petersen SE, Francis JM, WatkinsH,ClarkeK,RobsonMD, Neubauer S (2009) (31)P cardiac magnetic resonance spectroscopy during leg exercise at 3 Tesla. Int J Cardiovasc Imaging 25(8):819-826. doi:10.1007/s10554-009-9492-8
21. Rider OJ, Lewandowski A, Nethononda R, Petersen SE, Francis JM, Pitcher A, Holloway CJ, Dass S, Banerjee R, Byrne JP, Leeson P, Neubauer S (2012) Gender-specific differences in left ventricular remodelling in obesity: insights from cardiovascular magnetic resonance imaging. Eur Heart J. doi:10.1093/eurheartj/ehs341
22. Karamitsos TD, Arnold JR, Rider OJ, Francis JM, Ferrett C, Neubauer S, Becher H (2009) Massive hiatus hernia impeding transoesophageal echocardiography in a patient with swallowsyncope syndrome. Hellenic J Cardiol 50(3):216-217
23. Zeidan Z, Erbel R, Barkhausen J, Hunold P, Bartel T, Buck T (2003) Analysis of global systolic and diastolic left ventricular performance using volume-time curves by real-time three-dimensional echocardiography. J Am Soc Echocardiogr 16(1):29-37. doi:10.1067/mje.2003.40
24. Scheuermann-Freestone M, Madsen PL, Manners D, Blamire AM, Buckingham RE, Styles P, Radda GK, Neubauer S, Clarke K (2003) Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation 107(24): 3040-3046
25. Duncan MH, Singh BM, Wise PH, Carter G, Alaghband-Zadeh J (1995) A simple measure of insulin resistance. Lancet 346(8967):120-121
26. Tintera J, Harantova P, Suchanek P, Dvorakova A, Adamova M, Hajek M, Poledne R (2004) Quantification of intra-abdominal fat during controlled weight reduction: assessment using the watersuppressed breath-hold MRI technique. Physiol Res 53(2):229-234
27. Knaapen P, Germans T, Knuuti J, Paulus WJ, Dijkmans PA, Allaart CP, Lammertsma AA, Visser FC (2007) Myocardial energetics and efficiency: current status of the noninvasive approach. Circulation 115(7):918-927. doi:10.1161/CIRCULATIONAHA.106.660639
28. Taegtmeyer H (1994) Energy metabolism of the heart: from basic concepts to clinical applications. Curr Probl Cardiol 19(2): 59-113
29. Ashrafian H, le Roux CW, Darzi A, Athanasiou T (2008) Effects of bariatric surgery on cardiovascular function. Circulation 118(20):2091-2102. doi:10.1161/CIRCULATIONAHA.107.721027
30. Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH, Kelley DE (2005) Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 54(1):8-14
31. Chanseaume E, Barquissau V, Salles J, Aucouturier J, Patrac V, Giraudet C, Gryson C, Duche P, Boirie Y, Chardigny JM, Morio B (2010) Muscle mitochondrial oxidative phosphorylation activity, but not content, is altered with abdominal obesity in sedentary men: synergism with changes in insulin sensitivity. J Clin Endocrinol Metab 95(6):2948-2956. doi:10.1210/jc.2009-1938
32. Utz W, Engeli S, Haufe S, Kast P, Bohnke J, Haas V, Hermsdorf M, Wiesner S, Pofahl M, Traber J, Luft FC, Boschmann M, Jordan J, Schulz-Menger J (2012) Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women. Int J Cardiol. doi:10.1016/j.ijcard.2012.03.104
33. Bakermans AJ, Geraedts TR, van Weeghel M, Denis S, Ferraz MJ, Aerts JMFG, Aten J, Nicolay K, Houten SM, Prompers JJ (2011) Fasting-induced myocardial lipid accumulation in longchain acyl-CoA dehydrogenase knockout mice is accompanied by impaired left ventricular function. Circ Cardiovasc Imaging 4(5):558-565. doi:10.1161/Circimaging.111.963751