메뉴 건너뛰기




Volumn 313, Issue 5, 2017, Pages H1054-H1062

Exercise of obese mice induces cardioprotection and oxygen sparing in hearts exposed to high-fat load

Author keywords

Cardiac efficiency; Fatty acids; Ischemia reperfusion; Myocardial oxygen consumption; Obesity

Indexed keywords

INSULIN; OXYGEN; FATTY ACID; GLUCOSE BLOOD LEVEL;

EID: 85033215915     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00382.2017     Document Type: Article
Times cited : (19)

References (45)
  • 2
    • 0037315085 scopus 로고    scopus 로고
    • Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice
    • Aasum E, Hafstad AD, Severson DL, Larsen TS. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes 52: 434-441, 2003. doi:10.2337/diabetes.52.2.434.
    • (2003) Diabetes , vol.52 , pp. 434-441
    • Aasum, E.1    Hafstad, A.D.2    Severson, D.L.3    Larsen, T.S.4
  • 4
    • 53049096984 scopus 로고    scopus 로고
    • Exercise training initiated after the onset of diabetes preserves myocardial function: Effects on expression of beta-adrenoceptors
    • Bidasee KR, Zheng H, Shao CH, Parbhu SK, Rozanski GJ, Patel KP. Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of beta-adrenoceptors. J Appl Physiol 105: 907-914, 2008. doi:10.1152/japplphysiol.00103.2008.
    • (2008) J Appl Physiol , vol.105 , pp. 907-914
    • Bidasee, K.R.1    Zheng, H.2    Shao, C.H.3    Parbhu, S.K.4    Rozanski, G.J.5    Patel, K.P.6
  • 7
    • 79955779182 scopus 로고    scopus 로고
    • Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling.
    • Boardman NT, Larsen TS, Severson DL, Essop MF, Aasum E. Chronic and acute exposure of mouse hearts to fatty acids increases oxygen cost of excitation-contraction coupling. Am J Physiol Heart Circ Physiol 300: H1631-H1636, 2011. doi:10.1152/ajpheart.01190.2010.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300 , pp. H1631-H1636
    • Boardman, N.T.1    Larsen, T.S.2    Severson, D.L.3    Essop, M.F.4    Aasum, E.5
  • 8
    • 27444441492 scopus 로고    scopus 로고
    • Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity
    • Boudina S, Sena S, O’Neill BT, Tathireddy P, Young ME, Abel ED. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 112: 2686-2695, 2005. doi:10.1161/CIRCULATI0NAHA.105.554360.
    • (2005) Circulation , vol.112 , pp. 2686-2695
    • Boudina, S.1    Sena, S.2    O’Neill, B.T.3    Tathireddy, P.4    Young, M.E.5    Abel, E.D.6
  • 9
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncou-pled respiration and activation of uncoupling proteins
    • Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncou-pled respiration and activation of uncoupling proteins. Diabetes 56: 2457-2466, 2007. doi:10.2337/db07-0481.
    • (2007) Diabetes , vol.56 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3    Sheng, X.4    Wright, J.J.5    Hu, X.X.6    Aziz, S.7    Johnson, J.I.8    Bugger, H.9    Zaha, V.G.10    Abel, E.D.11
  • 10
    • 0028207450 scopus 로고
    • Exercise training improves metabolic response after ischemia in isolated working rat heart
    • Bowles DK, Starnes JW. Exercise training improves metabolic response after ischemia in isolated working rat heart. J Appl Physiol 76: 1608-1614, 1994.
    • (1994) J Appl Physiol , vol.76 , pp. 1608-1614
    • Bowles, D.K.1    Starnes, J.W.2
  • 11
    • 12744280913 scopus 로고    scopus 로고
    • Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetes
    • Broderick TL, Poirier P, Gillis M. Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetes. Diabetes Metab Res Rev 21: 44-50, 2005. doi:10.1002/dmrr.479.
    • (2005) Diabetes Metab Res Rev , vol.21 , pp. 44-50
    • Broderick, T.L.1    Poirier, P.2    Gillis, M.3
  • 14
    • 84873587521 scopus 로고    scopus 로고
    • Exercise training prevents the development of cardiac dysfunction in the low-dose streptozotocin diabetic rats fed a high-fat diet
    • Epp RA, Susser SE, Morissette MP, Kehler DS, Jassal DS, Duhamel TA. Exercise training prevents the development of cardiac dysfunction in the low-dose streptozotocin diabetic rats fed a high-fat diet. Can J Physiol Pharmacol 91: 80-89, 2013. doi:10.1139/cjpp-2012-0294.
    • (2013) Can J Physiol Pharmacol , vol.91 , pp. 80-89
    • Epp, R.A.1    Susser, S.E.2    Morissette, M.P.3    Kehler, D.S.4    Jassal, D.S.5    Duhamel, T.A.6
  • 15
    • 34047176377 scopus 로고    scopus 로고
    • Effects of palmitate on Ca2+ handling in adult control and ob/ob cardiomyocytes: Impact of mitochondrial reactive oxygen species
    • Fauconnier J, Andersson DC, Zhang SJ, Lanner JT, Wibom R, Katz A, Bruton JD, Westerblad H. Effects of palmitate on Ca2+ handling in adult control and ob/ob cardiomyocytes: impact of mitochondrial reactive oxygen species. Diabetes 56: 1136-1142, 2007. doi:10.2337/db06-0739.
    • (2007) Diabetes , vol.56 , pp. 1136-1142
    • Fauconnier, J.1    Ersson, D.C.2    Zhang, S.J.3    Lanner, J.T.4    Wibom, R.5    Katz, A.6    Bruton, J.D.7    Westerblad, H.8
  • 17
    • 67349249773 scopus 로고    scopus 로고
    • High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency
    • Folmes CD, Sowah D, Clanachan AS, Lopaschuk GD. High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency. J Mol Cell Cardiol 47: 142-148, 2009. doi:10.1016/j.yjmcc.2009.03.005.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 142-148
    • Folmes, C.D.1    Sowah, D.2    Clanachan, A.S.3    Lopaschuk, G.D.4
  • 18
    • 79959452607 scopus 로고    scopus 로고
    • Molecular mechanisms in exercise-induced cardio-protection
    • Golbidi S, Laher I. Molecular mechanisms in exercise-induced cardio-protection. Cardiol Res Pract 2011: 97-2807, 2011. doi:10.4061/2011/972807.
    • (2011) Cardiol Res Pract , vol.2011 , pp. 97-2807
    • Golbidi, S.1    Laher, I.2
  • 19
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl JMed 339: 229-234, 1998. doi:10.1056/NEJM199807233390404.
    • (1998) N Engl Jmed , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Rönnemaa, T.3    Pyörälä, K.4    Laakso, M.5
  • 20
    • 84930686190 scopus 로고    scopus 로고
    • Hafstad AD, Boardman N, Aasum E. How exercise may amend metabolic disturbances in diabetic cardiomyopathy. Antioxid Redox Signal 22: 1587-1605, 2015. doi:10.1089/ars.2015.6304.
    • (2015) Antioxid Redox Signal , vol.22 , pp. 1587-1605
    • Hafstad, A.D.1    Boardman, N.2    Aasum, E.3
  • 21
    • 81355150529 scopus 로고    scopus 로고
    • High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart.
    • Hafstad AD, Boardman NT, Lund J, Hagve M, Khalid AM, Wisloff U, Larsen TS, Aasum E. High intensity interval training alters substrate utilization and reduces oxygen consumption in the heart. J Appl Physiol 111: 1235-1241, 2011. doi:10.1152/japplphysiol.00594.2011.
    • (2011) J Appl Physiol , vol.111 , pp. 1235-1241
    • Hafstad, A.D.1    Boardman, N.T.2    Lund, J.3    Hagve, M.4    Khalid, A.M.5    Wisloff, U.6    Larsen, T.S.7    Aasum, E.8
  • 22
    • 85047686971 scopus 로고    scopus 로고
    • High-and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity
    • Hafstad AD, Lund J, Hadler-Olsen E, Höper AC, Larsen TS, Aasum E. High-and moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity. Diabetes 62: 2287-2294, 2013. doi:10.2337/db12-1580.
    • (2013) Diabetes , vol.62 , pp. 2287-2294
    • Hafstad, A.D.1    Lund, J.2    Hadler-Olsen, E.3    Höper, A.C.4    Larsen, T.S.5    Aasum, E.6
  • 24
    • 0025764546 scopus 로고
    • Exercise physiology in cardiovascular diseases
    • Hiatt WR. Exercise physiology in cardiovascular diseases. Curr Opin Cardiol 6: 745-749, 1991. doi:10.1097/00001573-199110000-00013.
    • (1991) Curr Opin Cardiol , vol.6 , pp. 745-749
    • Hiatt, W.R.1
  • 25
    • 19344363256 scopus 로고    scopus 로고
    • Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts
    • How OJ, Aasum E, Kunnathu S, Severson DL, Myhre ES, Larsen TS. Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts. Am J Physiol Heart Circ Physiol 288: H2979-H2985, 2005. doi:10.1152/ajpheart.00084.2005.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288 , pp. H2979-H2985
    • How, O.J.1    Aasum, E.2    Kunnathu, S.3    Severson, D.L.4    Myhre, E.S.5    Larsen, T.S.6
  • 26
    • 33644784921 scopus 로고    scopus 로고
    • Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    • How OJ, Aasum E, Severson DL, Chan WY, Essop MF, Larsen TS. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 55: 466-473, 2006. doi:10.2337/diabetes.55.02.06.db05-1164.
    • (2006) Diabetes , vol.55 , pp. 466-473
    • How, O.J.1    Aasum, E.2    Severson, D.L.3    Chan, W.Y.4    Essop, M.F.5    Larsen, T.S.6
  • 27
    • 0842341728 scopus 로고
    • Effect of fatty acid oxidation on efficiency of energy production in rat heart
    • Hütter JF, Piper HM, Spieckerman PG. Effect of fatty acid oxidation on efficiency of energy production in rat heart. Am J Physiol Heart Circ Physiol 249: H723-H728, 1985.
    • (1985) Am J Physiol Heart Circ Physiol , vol.249 , pp. H723-H728
    • Hütter, J.F.1    Piper, H.M.2    Spieckerman, P.G.3
  • 28
    • 0018764335 scopus 로고
    • Diabetes and cardiovascular disease. The Framingham study
    • Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA 241: 2035-2038, 1979. doi:10.1001/jama.1979.03290450033020.
    • (1979) JAMA , vol.241 , pp. 2035-2038
    • Kannel, W.B.1    McGee, D.L.2
  • 29
    • 84962175121 scopus 로고    scopus 로고
    • Enhancing cardiac triacyl-glycerol metabolism improves recovery from ischemic stress
    • Kolwicz SC Jr, Liu L, Goldberg IJ, Tian R. enhancing cardiac triacyl-glycerol metabolism improves recovery from ischemic stress. Diabetes 64: 2817-2827, 2015. doi:10.2337/db14-1943.
    • (2015) Diabetes , vol.64 , pp. 2817-2827
    • Kolwicz, S.C.1    Liu, L.2    Goldberg, I.J.3    Tian, R.4
  • 30
    • 84921921766 scopus 로고    scopus 로고
    • Physical activity and diabetic cardiomyopathy: Myocardial adaptation depending on exercise load
    • Le Douairon Lahaye S, Bekono FR, Broderick T. Physical activity and diabetic cardiomyopathy: myocardial adaptation depending on exercise load. Curr Diabetes Rev 10: 371-390, 2014. doi:10.2174/1573399811666141229151421.
    • (2014) Curr Diabetes Rev , vol.10 , pp. 371-390
    • Le Douairon Lahaye, S.1    Bekono, F.R.2    Broderick, T.3
  • 31
    • 0037138548 scopus 로고    scopus 로고
    • High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation
    • Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol 39: 718-725, 2002. doi:10.1016/S0735-1097(01)01803-4.
    • (2002) J am Coll Cardiol , vol.39 , pp. 718-725
    • Liu, Q.1    Docherty, J.C.2    Rendell, J.C.3    Clanachan, A.S.4    Lopaschuk, G.D.5
  • 35
    • 0025169628 scopus 로고
    • Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts
    • McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol Heart Circ Physioll 259: H1079-H1085, 1990.
    • (1990) Am J Physiol Heart Circ Physioll , vol.259 , pp. H1079-H1085
    • McVeigh, J.J.1    Lopaschuk, G.D.2
  • 36
    • 0019178514 scopus 로고
    • Vigorous exercise in leisure-time: Protection against coronary heart disease
    • Morris JN, Everitt MG, Pollard R, Chave SP, Semmence AM. Vigorous exercise in leisure-time: protection against coronary heart disease. Lancet 2: 1207-1210, 1980. doi:10.1016/S0140-6736(80)92476-9.
    • (1980) Lancet , vol.2 , pp. 1207-1210
    • Morris, J.N.1    Everitt, M.G.2    Pollard, R.3    Chave, S.P.4    Semmence, A.M.5
  • 37
    • 0037076018 scopus 로고    scopus 로고
    • Exercise capacity and mortality among men referred for exercise testing
    • Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346: 793-801, 2002. doi:10.1056/NEJMoa011858.
    • (2002) N Engl J Med , vol.346 , pp. 793-801
    • Myers, J.1    Prakash, M.2    Froelicher, V.3    Do, D.4    Partington, S.5    Atwood, J.E.6
  • 39
    • 0014404611 scopus 로고
    • Relation between serum-free-fatty acids and arrhythmias and death after acute myocardial infarction
    • Oliver MF, Kurien VA, Greenwood TW. Relation between serum-free-fatty acids and arrhythmias and death after acute myocardial infarction. Lancet 291: 710-715, 1968. doi:10.1016/S0140-6736(68)92163-6.
    • (1968) Lancet , vol.291 , pp. 710-715
    • Oliver, M.F.1    Kurien, V.A.2    Greenwood, T.W.3
  • 40
    • 70350072972 scopus 로고    scopus 로고
    • The adrenergic-fatty acid load in heart failure
    • Opie LH, Knuuti J. The adrenergic-fatty acid load in heart failure. J Am Coll Cardiol 54: 1637-1646, 2009. doi:10.1016/j.jacc.2009.07.024.
    • (2009) J am Coll Cardiol , vol.54 , pp. 1637-1646
    • Opie, L.H.1    Knuuti, J.2
  • 41
    • 0022589439 scopus 로고
    • Physical activity, all-cause mortality, and longevity of college alumni
    • Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med 314: 605-613, 1986. doi:10.1056/NEJM198603063141003.
    • (1986) N Engl J Med , vol.314 , pp. 605-613
    • Paffenbarger, R.S.1    Hyde, R.T.2    Wing, A.L.3    Hsieh, C.C.4
  • 42
    • 84871823931 scopus 로고    scopus 로고
    • Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities
    • Pons S, Martin V, Portal L, Zini R, Morin D, Berdeaux A, Ghaleh B. Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities. J Mol Cell Cardiol 54: 82-89, 2013. doi:10.1016/j.yjmcc.2012.11.010.
    • (2013) J Mol Cell Cardiol , vol.54 , pp. 82-89
    • Pons, S.1    Martin, V.2    Portal, L.3    Zini, R.4    Morin, D.5    Berdeaux, A.6    Ghaleh, B.7
  • 43
    • 37849049214 scopus 로고    scopus 로고
    • Exercise-induced cardioprotec-tion against myocardial ischemia-reperfusion injury
    • Powers SK, Quindry JC, Kavazis AN. Exercise-induced cardioprotec-tion against myocardial ischemia-reperfusion injury. Free Radic Biol Med 44: 193-201, 2008. doi:10.1016/j.freeradbiomed.2007.02.006.
    • (2008) Free Radic Biol Med , vol.44 , pp. 193-201
    • Powers, S.K.1    Quindry, J.C.2    Kavazis, A.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.