-
1
-
-
85060343849
-
Human cognition involves the dynamic integration of neural activity and neuromodulatory systems
-
Shine JM, Breakspear M, Bell PT, Ehgoetz Martens KA, Shine R, Koyejo O, Sporns O, Poldrack RA (2019) Human cognition involves the dynamic integration of neural activity and neuromodulatory systems. Nat Neurosci 22, 289-296.
-
(2019)
Nat Neurosci
, vol.22
, pp. 289-296
-
-
Shine, J.M.1
Breakspear, M.2
Bell, P.T.3
Ehgoetz Martens, K.A.4
Shine, R.5
Koyejo, O.6
Sporns, O.7
Poldrack, R.A.8
-
2
-
-
84994464103
-
Network abnormalities and interneuron dysfunction in Alzheimer disease
-
Palop JJ, Mucke L (2016) Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci 17, 777.
-
(2016)
Nat Rev Neurosci
, vol.17
, pp. 777
-
-
Palop, J.J.1
Mucke, L.2
-
3
-
-
85060085145
-
Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis
-
Henstridge CM, Hyman BT, Spires-Jones TL (2019) Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nat Rev Neurosci 20, 94-108.
-
(2019)
Nat Rev Neurosci
, vol.20
, pp. 94-108
-
-
Henstridge, C.M.1
Hyman, B.T.2
Spires-Jones, T.L.3
-
4
-
-
70349859881
-
DNA damage, aging, and cancer
-
Hoeijmakers JHJ (2009) DNA damage, aging, and cancer. N Engl J Med 361, 1475-1485.
-
(2009)
N Engl J Med
, vol.361
, pp. 1475-1485
-
-
Hoeijmakers, J.H.J.1
-
5
-
-
85048637803
-
Revolution of Alzheimer Precision Neurology. Passageway of systems biology and neurophysiology
-
Hampel H, Toschi N, Babiloni C, Baldacci F, Black KL, Bokde ALW, Bun RS, Cacciola F, Cavedo E, Chiesa PA, Colliot O, Coman C-M, Dubois B, Duggento A, Durrleman S, Ferretti M-T, George N, Genthon R, Habert M-O, Herholz K, Koronyo Y, Koronyo-Hamaoui M, Lamari F, Langevin T, Lehericy S, Lorenceau J, Neri C, Nistico R, Nyasse-Messene F, Ritchie C, Rossi S, Santarnecchi E, Sporns O, Verdooner SR, Vergallo A, Villain N, Younesi E, Garaci F, Lista S (2018) Revolution of Alzheimer Precision Neurology. Passageway of systems biology and neurophysiology. J Alzheimers Dis 64, S47-S105.
-
(2018)
J Alzheimers Dis
, vol.64
, pp. S47-S105
-
-
Hampel, H.1
Toschi, N.2
Babiloni, C.3
Baldacci, F.4
Black, K.L.5
Bokde, A.L.W.6
Bun, R.S.7
Cacciola, F.8
Cavedo, E.9
Chiesa, P.A.10
Colliot, O.11
Coman, C.-M.12
Dubois, B.13
Duggento, A.14
Durrleman, S.15
Ferretti, M.-T.16
George, N.17
Genthon, R.18
Habert, M.-O.19
Herholz, K.20
Koronyo, Y.21
Koronyo-Hamaoui, M.22
Lamari, F.23
Langevin, T.24
Lehericy, S.25
Lorenceau, J.26
Neri, C.27
Nistico, R.28
Nyasse-Messene, F.29
Ritchie, C.30
Rossi, S.31
Santarnecchi, E.32
Sporns, O.33
Verdooner, S.R.34
Vergallo, A.35
Villain, N.36
Younesi, E.37
Garaci, F.38
Lista, S.39
more..
-
6
-
-
85061755242
-
Treatment combinations for Alzheimer's disease: Current and future pharmacotherapy options
-
Cummings JL, Tong G, Ballard C (2019) Treatment combinations for Alzheimer's disease: Current and future pharmacotherapy options. J Alzheimers Dis 67, 779-794.
-
(2019)
J Alzheimers Dis
, vol.67
, pp. 779-794
-
-
Cummings, J.L.1
Tong, G.2
Ballard, C.3
-
7
-
-
84869878419
-
Simulations of symptomatic treatments for Alzheimer's disease: Computational analysis of pathology and mechanisms of drug action
-
Roberts PD, Spiros A, Geerts H (2012) Simulations of symptomatic treatments for Alzheimer's disease: Computational analysis of pathology and mechanisms of drug action. Alzheimers Res Ther 4, 50.
-
(2012)
Alzheimers Res Ther
, vol.4
, pp. 50
-
-
Roberts, P.D.1
Spiros, A.2
Geerts, H.3
-
8
-
-
84888011244
-
Networkbased approaches in drug discovery and early development
-
Harrold JM, Ramanathan M, Mager DE (2013) Networkbased approaches in drug discovery and early development. Clin Pharmacol Ther 94, 651-658.
-
(2013)
Clin Pharmacol Ther
, vol.94
, pp. 651-658
-
-
Harrold, J.M.1
Ramanathan, M.2
Mager, D.E.3
-
9
-
-
84931292222
-
BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks
-
Richiardi J, Altmann A, Milazzo A-C, Chang C, Chakravarty MM, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Buchel C, Conrod P, Fauth-Buhler M, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Lemaitre H, Mann KF, Martinot J-L, Nees F, Paus T, Pausova Z, Rietschel M, Robbins TW, Smolka MN, Spanagel R, Strohle A, Schumann G, Hawrylycz M, Poline J-B, Greicius MD (2015) BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. Science 348, 1241-1244.
-
(2015)
Science
, vol.348
, pp. 1241-1244
-
-
Richiardi, J.1
Altmann, A.2
Milazzo, A.-C.3
Chang, C.4
Chakravarty, M.M.5
Banaschewski, T.6
Barker, G.J.7
Bokde, A.L.W.8
Bromberg, U.9
Buchel, C.10
Conrod, P.11
Fauth-Buhler, M.12
Flor, H.13
Frouin, V.14
Gallinat, J.15
Garavan, H.16
Gowland, P.17
Heinz, A.18
Lemaitre, H.19
Mann, K.F.20
Martinot, J.-L.21
Nees, F.22
Paus, T.23
Pausova, Z.24
Rietschel, M.25
Robbins, T.W.26
Smolka, M.N.27
Spanagel, R.28
Strohle, A.29
Schumann, G.30
Hawrylycz, M.31
Poline, J.-B.32
Greicius, M.D.33
more..
-
10
-
-
85061292708
-
Ultra-large library docking for discovering new chemotypes
-
Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ (2019) Ultra-large library docking for discovering new chemotypes. Nature 566, 224-229.
-
(2019)
Nature
, vol.566
, pp. 224-229
-
-
Lyu, J.1
Wang, S.2
Balius, T.E.3
Singh, I.4
Levit, A.5
Moroz, Y.S.6
O'Meara, M.J.7
Che, T.8
Algaa, E.9
Tolmachova, K.10
Tolmachev, A.A.11
Shoichet, B.K.12
Roth, B.L.13
Irwin, J.J.14
-
11
-
-
84855906454
-
Systems pharmacology: Network analysis to identify multiscale mechanisms of drug action
-
Zhao S, Iyengar R (2012) Systems pharmacology: Network analysis to identify multiscale mechanisms of drug action. Annu Rev Pharmacol Toxicol 52, 505-521.
-
(2012)
Annu Rev Pharmacol Toxicol
, vol.52
, pp. 505-521
-
-
Zhao, S.1
Iyengar, R.2
-
12
-
-
85042621386
-
Precision pharmacology for Alzheimer's disease
-
Hampel H, Vergallo A, Aguilar LF, Benda N, Broich K, Cuello AC, Cummings J, Dubois B, Federoff HJ, Fiandaca M, Genthon R, Haberkamp M, Karran E, Mapstone M, Perry G, Schneider LS, Welikovitch LA, Woodcock J, Baldacci F, Lista S (2018) Precision pharmacology for Alzheimer's disease. Pharmacol Res 130, 331-365.
-
(2018)
Pharmacol Res
, vol.130
, pp. 331-365
-
-
Hampel, H.1
Vergallo, A.2
Aguilar, L.F.3
Benda, N.4
Broich, K.5
Cuello, A.C.6
Cummings, J.7
Dubois, B.8
Federoff, H.J.9
Fiandaca, M.10
Genthon, R.11
Haberkamp, M.12
Karran, E.13
Mapstone, M.14
Perry, G.15
Schneider, L.S.16
Welikovitch, L.A.17
Woodcock, J.18
Baldacci, F.19
Lista, S.20
more..
-
13
-
-
85042594084
-
Efficacy of Larotrectinib in TRK fusion-positive cancers in adults and children
-
Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, BoniV, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM (2018) Efficacy of Larotrectinib in TRK fusion-positive cancers in adults and children. N Engl J Med 378, 731-739.
-
(2018)
N Engl J Med
, vol.378
, pp. 731-739
-
-
Drilon, A.1
Laetsch, T.W.2
Kummar, S.3
DuBois, S.G.4
Lassen, U.N.5
Demetri, G.D.6
Nathenson, M.7
Doebele, R.C.8
Farago, A.F.9
Pappo, A.S.10
Turpin, B.11
Dowlati, A.12
Brose, M.S.13
Mascarenhas, L.14
Federman, N.15
Berlin, J.16
El-Deiry, W.S.17
Baik, C.18
Deeken, J.19
Boniv20
Nagasubramanian, R.21
Taylor, M.22
Rudzinski, E.R.23
Meric-Bernstam, F.24
Sohal, D.P.S.25
Ma, P.C.26
Raez, L.E.27
Hechtman, J.F.28
Benayed, R.29
Ladanyi, M.30
Tuch, B.B.31
Ebata, K.32
Cruickshank, S.33
Ku, N.C.34
Cox, M.C.35
Hawkins, D.S.36
Hong, D.S.37
Hyman, D.M.38
more..
-
14
-
-
85006626463
-
Cancer precision medicine: From cancer screening to drug selection and personalized immunotherapy
-
Deng X, Nakamura Y (2017) Cancer precision medicine: From cancer screening to drug selection and personalized immunotherapy. Trends Pharmacol Sci 38, 15-24.
-
(2017)
Trends Pharmacol Sci
, vol.38
, pp. 15-24
-
-
Deng, X.1
Nakamura, Y.2
-
15
-
-
84901626678
-
Genomicsenabled drug repositioning and repurposing: Insights from an IOM Roundtable activity
-
Power A, Berger AC, Ginsburg GS (2014) Genomicsenabled drug repositioning and repurposing: Insights from an IOM Roundtable activity. JAMA 311, 2063-2064.
-
(2014)
JAMA
, vol.311
, pp. 2063-2064
-
-
Power, A.1
Berger, A.C.2
Ginsburg, G.S.3
-
16
-
-
85011851560
-
A Precision Medicine Initiative for Alzheimer's disease: The road ahead to biomarker-guided integrative disease modeling
-
Hampel H, O'Bryant SE, Durrleman S, Younesi E, Rojkova K, Escott-Price V, Corvol J-C, Broich K, Dubois B, Lista S (2017) A Precision Medicine Initiative for Alzheimer's disease: The road ahead to biomarker-guided integrative disease modeling. Climacteric 20, 107-118.
-
(2017)
Climacteric
, vol.20
, pp. 107-118
-
-
Hampel, H.1
O'Bryant, S.E.2
Durrleman, S.3
Younesi, E.4
Rojkova, K.5
Escott-Price, V.6
Corvol, J.-C.7
Broich, K.8
Dubois, B.9
Lista, S.10
-
17
-
-
84880964331
-
Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology
-
Perez-Nievas BG, Stein TD, Tai H-C, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, Ikonomovic MD, Lopez OL, Klunk W, Hyman BT, Gomez-Isla T (2013) Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain 136, 2510-2526.
-
(2013)
Brain
, vol.136
, pp. 2510-2526
-
-
Perez-Nievas, B.G.1
Stein, T.D.2
Tai, H.-C.3
Dols-Icardo, O.4
Scotton, T.C.5
Barroeta-Espar, I.6
Fernandez-Carballo, L.7
De Munain, E.L.8
Perez, J.9
Marquie, M.10
Serrano-Pozo, A.11
Frosch, M.P.12
Lowe, V.13
Parisi, J.E.14
Petersen, R.C.15
Ikonomovic, M.D.16
Lopez, O.L.17
Klunk, W.18
Hyman, B.T.19
Gomez-Isla, T.20
more..
-
18
-
-
85044515982
-
Brain aging and APOE epsilon4 interact to reveal potential neuronal compensation in healthy older adults
-
Scheller E, Schumacher LV, Peter J, Lahr J, Wehrle J, Kaller CP, Gaser C, Kloppel S (2018) Brain aging and APOE epsilon4 interact to reveal potential neuronal compensation in healthy older adults. Front Aging Neurosci 10, 74.
-
(2018)
Front Aging Neurosci
, vol.10
, pp. 74
-
-
Scheller, E.1
Schumacher, L.V.2
Peter, J.3
Lahr, J.4
Wehrle, J.5
Kaller, C.P.6
Gaser, C.7
Kloppel, S.8
-
19
-
-
80052749028
-
Divergent network connectivity changes in healthy APOE epsilon4 carriers: Disinhibition or compensation?
-
Seeley WW (2011) Divergent network connectivity changes in healthy APOE epsilon4 carriers: Disinhibition or compensation? Arch Neurol 68, 1107-1108.
-
(2011)
Arch Neurol
, vol.68
, pp. 1107-1108
-
-
Seeley, W.W.1
-
20
-
-
85054570892
-
Blood-based biomarkers for Alzheimer disease: Mapping the road to the clinic
-
Hampel H, O'Bryant SE, Molinuevo JL, Zetterberg H, Masters CL, Lista S, Kiddle SJ, Batrla R, Blennow K (2018) Blood-based biomarkers for Alzheimer disease: Mapping the road to the clinic. Nat Rev Neurol 14, 639-652.
-
(2018)
Nat Rev Neurol
, vol.14
, pp. 639-652
-
-
Hampel, H.1
O'Bryant, S.E.2
Molinuevo, J.L.3
Zetterberg, H.4
Masters, C.L.5
Lista, S.6
Kiddle, S.J.7
Batrla, R.8
Blennow, K.9
-
21
-
-
84929948919
-
Lithium in the treatment of bipolar disorder: Pharmacology and pharmacogenetics
-
Alda M (2015) Lithium in the treatment of bipolar disorder: Pharmacology and pharmacogenetics. Mol Psychiatry 20, 661-670.
-
(2015)
Mol Psychiatry
, vol.20
, pp. 661-670
-
-
Alda, M.1
-
22
-
-
84941278298
-
Lithium as a treatment for Alzheimer's disease: A systematic review and meta-analysis
-
Matsunaga S, Kishi T, Annas P, Basun H, Hampel H, Iwata N (2015) Lithium as a treatment for Alzheimer's disease: A systematic review and meta-analysis. J Alzheimers Dis 48, 403-410.
-
(2015)
J Alzheimers Dis
, vol.48
, pp. 403-410
-
-
Matsunaga, S.1
Kishi, T.2
Annas, P.3
Basun, H.4
Hampel, H.5
Iwata, N.6
-
23
-
-
67649206084
-
Lithium trial in Alzheimer's disease: A randomized, single-blind, placebo-controlled, multicenter 10-week study
-
Hampel H, Ewers M, Burger K, Annas P, Mortberg A, Bogstedt A, Frolich L, Schroder J, Schonknecht P, Riepe MW, Kraft I, Gasser T, Leyhe T, Moller H-J, Kurz A, Basun H (2009) Lithium trial in Alzheimer's disease: A randomized, single-blind, placebo-controlled, multicenter 10-week study. J Clin Psychiatry 70, 922-931.
-
(2009)
J Clin Psychiatry
, vol.70
, pp. 922-931
-
-
Hampel, H.1
Ewers, M.2
Burger, K.3
Annas, P.4
Mortberg, A.5
Bogstedt, A.6
Frolich, L.7
Schroder, J.8
Schonknecht, P.9
Riepe, M.W.10
Kraft, I.11
Gasser, T.12
Leyhe, T.13
Moller, H.-J.14
Kurz, A.15
Basun, H.16
-
24
-
-
67649199941
-
Can lithium or valproate untie tangles in Alzheimer's disease?
-
Tariot PN, Aisen PS (2009) Can lithium or valproate untie tangles in Alzheimer's disease? J Clin Psychiatry 70, 919-921.
-
(2009)
J Clin Psychiatry
, vol.70
, pp. 919-921
-
-
Tariot, P.N.1
Aisen, P.S.2
-
25
-
-
84975764391
-
Lithium, a therapy for AD: Current evidence from clinical trials of neurodegenerative disorders
-
Forlenza OV, Aprahamian I, de Paula VJ, Hajek T (2016) Lithium, a therapy for AD: Current evidence from clinical trials of neurodegenerative disorders. Curr Alzheimer Res 13, 879-886.
-
(2016)
Curr Alzheimer Res
, vol.13
, pp. 879-886
-
-
Forlenza, O.V.1
Aprahamian, I.2
De Paula, V.J.3
Hajek, T.4
-
26
-
-
85054875049
-
Molecular mechanisms of lithium action: Switching the light on multiple targets for dementia using animal models
-
Kerr F, Bjedov I, Sofola-Adesakin O (2018) Molecular mechanisms of lithium action: Switching the light on multiple targets for dementia using animal models. Front Mol Neurosci 11, 297.
-
(2018)
Front Mol Neurosci
, vol.11
, pp. 297
-
-
Kerr, F.1
Bjedov, I.2
Sofola-Adesakin, O.3
-
27
-
-
84856702223
-
Inhibition of GSK3 by lithium, from single molecules to signaling networks
-
Freland L, Beaulieu J-M (2012) Inhibition of GSK3 by lithium, from single molecules to signaling networks. Front Mol Neurosci 5, 14.
-
(2012)
Front Mol Neurosci
, vol.5
, pp. 14
-
-
Freland, L.1
Beaulieu, J.-M.2
-
28
-
-
84888205849
-
Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid
-
Braak H, Zetterberg H, Del Tredici K, Blennow K (2013) Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol 126, 631-641.
-
(2013)
Acta Neuropathol
, vol.126
, pp. 631-641
-
-
Braak, H.1
Zetterberg, H.2
Del Tredici, K.3
Blennow, K.4
-
29
-
-
85059560378
-
Acritical appraisal of amyloid-beta-targeting therapies for Alzheimer disease
-
Panza F, Lozupone M, Logroscino G, Imbimbo BP (2019) Acritical appraisal of amyloid-beta-targeting therapies for Alzheimer disease. Nat Rev Neurol 15, 73-88.
-
(2019)
Nat Rev Neurol
, vol.15
, pp. 73-88
-
-
Panza, F.1
Lozupone, M.2
Logroscino, G.3
Imbimbo, B.P.4
-
30
-
-
85027585635
-
Amyloid in Alzheimer's disease: Guilty beyond reasonable doubt?
-
Behl C (2017) Amyloid in Alzheimer's disease: Guilty beyond reasonable doubt? Trends Pharmacol Sci 38, 849-851.
-
(2017)
Trends Pharmacol Sci
, vol.38
, pp. 849-851
-
-
Behl, C.1
-
31
-
-
85048357589
-
Tau-targeting therapies for Alzheimer disease
-
Congdon EE, Sigurdsson EM (2018) Tau-targeting therapies for Alzheimer disease. Nat Rev Neurol 14, 399-415.
-
(2018)
Nat Rev Neurol
, vol.14
, pp. 399-415
-
-
Congdon, E.E.1
Sigurdsson, E.M.2
-
32
-
-
85060910289
-
Chronic lithium treatment increases telomere length in parietal cortex and hippocampus of triple-transgenic Alzheimer's disease mice
-
Cardillo G de M, De-Paula V de JR, Ikenaga EH, Costa LR, Catanozi S, Schaeffer EL, Gattaz WF, Kerr DS, Forlenza OV (2018) Chronic lithium treatment increases telomere length in parietal cortex and hippocampus of triple-transgenic Alzheimer's disease mice. J Alzheimers Dis 63, 93-101.
-
(2018)
J Alzheimers Dis
, vol.63
, pp. 93-101
-
-
Cardillo, G.1
De, M.2
De-Paula, V.3
De, J.R.4
Ikenaga, E.H.5
Costa, L.R.6
Catanozi, S.7
Schaeffer, E.L.8
Gattaz, W.F.9
Kerr, D.S.10
Forlenza, O.V.11
-
33
-
-
84911439045
-
Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model
-
Zhao L, Gong N, Liu M, Pan X, Sang S, Sun X, Yu Z, Fang Q, Zhao N, Fei G, Jin L, Zhong C, Xu T (2014) Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model. Neurobiol Aging 35, 2736-2745.
-
(2014)
Neurobiol Aging
, vol.35
, pp. 2736-2745
-
-
Zhao, L.1
Gong, N.2
Liu, M.3
Pan, X.4
Sang, S.5
Sun, X.6
Yu, Z.7
Fang, Q.8
Zhao, N.9
Fei, G.10
Jin, L.11
Zhong, C.12
Xu, T.13
-
34
-
-
85039966225
-
Lithium, stress, and resilience in bipolar disorder: Deciphering this key homeostatic synaptic plasticity regulator
-
Machado-Vieira R (2018) Lithium, stress, and resilience in bipolar disorder: Deciphering this key homeostatic synaptic plasticity regulator. J Affect Disord 233, 92-99.
-
(2018)
J Affect Disord
, vol.233
, pp. 92-99
-
-
Machado-Vieira, R.1
-
35
-
-
84880060576
-
Targeting synaptic dysfunction in Alzheimer's disease therapy
-
Nistico R, Pignatelli M, Piccinin S, Mercuri NB, Collingridge G (2012) Targeting synaptic dysfunction in Alzheimer's disease therapy. Mol Neurobiol 46, 572-587.
-
(2012)
Mol Neurobiol
, vol.46
, pp. 572-587
-
-
Nistico, R.1
Pignatelli, M.2
Piccinin, S.3
Mercuri, N.B.4
Collingridge, G.5
-
36
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
-
(2002)
Science
, vol.298
, pp. 789-791
-
-
Selkoe, D.J.1
-
38
-
-
18744438248
-
Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor
-
Xie L, Helmerhorst E, Taddei K, Plewright B, Van Bronswijk W, Martins R (2002) Alzheimer's beta-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 22, RC221.
-
(2002)
J Neurosci
, vol.22
, pp. RC221
-
-
Xie, L.1
Helmerhorst, E.2
Taddei, K.3
Plewright, B.4
Van Bronswijk, W.5
Martins, R.6
-
39
-
-
36348935683
-
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
-
Townsend M, Mehta T, Selkoe DJ (2007) Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 282, 33305-33312.
-
(2007)
J Biol Chem
, vol.282
, pp. 33305-33312
-
-
Townsend, M.1
Mehta, T.2
Selkoe, D.J.3
-
41
-
-
39849110726
-
The GSK3 hypothesis of Alzheimer's disease
-
Hooper C, Killick R, Lovestone S (2008) The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104, 1433-1439.
-
(2008)
J Neurochem
, vol.104
, pp. 1433-1439
-
-
Hooper, C.1
Killick, R.2
Lovestone, S.3
-
42
-
-
3343005434
-
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations
-
Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations. EMBO J 23, 2586-2596.
-
(2004)
EMBO J
, vol.23
, pp. 2586-2596
-
-
Baki, L.1
Shioi, J.2
Wen, P.3
Shao, Z.4
Schwarzman, A.5
Gama-Sosa, M.6
Neve, R.7
Robakis, N.K.8
-
43
-
-
44049089139
-
Amyloid-beta binds to the extracellular cysteinerich domain of Frizzled and inhibits Wnt/beta-catenin signaling
-
Magdesian MH, Carvalho MMVF, Mendes FA, Saraiva LM, Juliano MA, Juliano L, Garcia-Abreu J, Ferreira ST (2008) Amyloid-beta binds to the extracellular cysteinerich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem 283, 9359-9368.
-
(2008)
J Biol Chem
, vol.283
, pp. 9359-9368
-
-
Magdesian, M.H.1
Carvalho, M.M.V.F.2
Mendes, F.A.3
Saraiva, L.M.4
Juliano, M.A.5
Juliano, L.6
Garcia-Abreu, J.7
Ferreira, S.T.8
-
44
-
-
84872587279
-
GSK3 and tau: Two convergence points in Alzheimer's disease
-
Hernandez F, Lucas JJ, Avila J (2013) GSK3 and tau: Two convergence points in Alzheimer's disease. J Alzheimers Dis 33(Suppl 1), S141-144.
-
(2013)
J Alzheimers Dis
, vol.33
, pp. S141-S144
-
-
Hernandez, F.1
Lucas, J.J.2
Avila, J.3
-
45
-
-
56149105343
-
GSK-3beta is required for memory reconsolidation in adult brain
-
Kimura T, Yamashita S, Nakao S, Park J-M, Murayama M, Mizoroki T, Yoshiike Y, Sahara N, Takashima A (2008) GSK-3beta is required for memory reconsolidation in adult brain. PLoS One 3, e3540.
-
(2008)
PLoS One
, vol.3
-
-
Kimura, T.1
Yamashita, S.2
Nakao, S.3
Park, J.-M.4
Murayama, M.5
Mizoroki, T.6
Yoshiike, Y.7
Sahara, N.8
Takashima, A.9
-
46
-
-
3042558276
-
Glycogen synthase kinase 3: A drug target for CNS therapies
-
Bhat R V, Budd Haeberlein SL, Avila J (2004) Glycogen synthase kinase 3: A drug target for CNS therapies. J Neurochem 89, 1313-1317.
-
(2004)
J Neurochem
, vol.89
, pp. 1313-1317
-
-
Bhat, R.V.1
Budd Haeberlein, S.L.2
Avila, J.3
-
47
-
-
33947597084
-
Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics
-
Jope RS, Yuskaitis CJ, Beurel E (2007) Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics. Neurochem Res 32, 577-595.
-
(2007)
Neurochem Res
, vol.32
, pp. 577-595
-
-
Jope, R.S.1
Yuskaitis, C.J.2
Beurel, E.3
-
48
-
-
79955484857
-
Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta
-
Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo SC, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, Cho K (2011) Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta. Nat Neurosci 14, 545-547.
-
(2011)
Nat Neurosci
, vol.14
, pp. 545-547
-
-
Jo, J.1
Whitcomb, D.J.2
Olsen, K.M.3
Kerrigan, T.L.4
Lo, S.C.5
Bru-Mercier, G.6
Dickinson, B.7
Scullion, S.8
Sheng, M.9
Collingridge, G.10
Cho, K.11
-
49
-
-
33846259727
-
Glycogen synthase kinase-3 inhibition is integral to long-term potentiation
-
Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, Cooke SF, Avila J, Lucas JJ, Giese KP, Stephenson J, Lovestone S (2007) Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. Eur J Neurosci 25, 81-86.
-
(2007)
Eur J Neurosci
, vol.25
, pp. 81-86
-
-
Hooper, C.1
Markevich, V.2
Plattner, F.3
Killick, R.4
Schofield, E.5
Engel, T.6
Hernandez, F.7
Anderton, B.8
Rosenblum, K.9
Bliss, T.10
Cooke, S.F.11
Avila, J.12
Lucas, J.J.13
Giese, K.P.14
Stephenson, J.15
Lovestone, S.16
-
50
-
-
79551510136
-
Tau protein is required for amyloid beta-induced impairment of hippocampal long-term potentiation
-
Shipton OA, Leitz JR, Dworzak J, Acton CEJ, Tunbridge EM, Denk F, Dawson HN, Vitek MP, Wade-Martins R, Paulsen O, Vargas-Caballero M (2011) Tau protein is required for amyloid beta-induced impairment of hippocampal long-term potentiation. J Neurosci 31, 1688-1692.
-
(2011)
J Neurosci
, vol.31
, pp. 1688-1692
-
-
Shipton, O.A.1
Leitz, J.R.2
Dworzak, J.3
Acton, C.E.J.4
Tunbridge, E.M.5
Denk, F.6
Dawson, H.N.7
Vitek, M.P.8
Wade-Martins, R.9
Paulsen, O.10
Vargas-Caballero, M.11
-
51
-
-
77958465822
-
Dysregulation of themTORpathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease
-
Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK (2010) Dysregulation of themTORpathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One 5, e12845.
-
(2010)
PLoS One
, vol.5
-
-
Ma, T.1
Hoeffer, C.A.2
Capetillo-Zarate, E.3
Yu, F.4
Wong, H.5
Lin, M.T.6
Tampellini, D.7
Klann, E.8
Blitzer, R.D.9
Gouras, G.K.10
-
52
-
-
84993973237
-
Stereological investigation of theCA1pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice
-
Schaeffer EL, Catanozi S, West MJ, Gattaz WF (2017) Stereological investigation of theCA1pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice. Ann Anat 209, 51-60.
-
(2017)
Ann Anat
, vol.209
, pp. 51-60
-
-
Schaeffer, E.L.1
Catanozi, S.2
West, M.J.3
Gattaz, W.F.4
-
53
-
-
79959276349
-
Long-term treatment with lithium alleviates memory deficits and reduces amyloid-beta production in an aged Alzheimer's disease transgenic mouse model
-
Zhang X, Heng X, Li T, Li L, Yang D, Zhang X, Du Y, Doody RS, Le W (2011) Long-term treatment with lithium alleviates memory deficits and reduces amyloid-beta production in an aged Alzheimer's disease transgenic mouse model. J Alzheimers Dis 24, 739-749.
-
(2011)
J Alzheimers Dis
, vol.24
, pp. 739-749
-
-
Zhang, X.1
Heng, X.2
Li, T.3
Li, L.4
Yang, D.5
Zhang, X.6
Du, Y.7
Doody, R.S.8
Le, W.9
-
54
-
-
85020863180
-
LISPRO mitigates beta-amyloid and associated pathologies in Alzheimer's mice
-
Habib A, Sawmiller D, Li S, Xiang Y, Rongo D, Tian J, Hou H, Zeng J, Smith A, Fan S, Giunta B, Mori T, Currier G, Shytle DR, Tan J (2017) LISPRO mitigates beta-amyloid and associated pathologies in Alzheimer's mice. Cell Death Dis 8, e2880.
-
(2017)
Cell Death Dis
, vol.8
, pp. e2880
-
-
Habib, A.1
Sawmiller, D.2
Li, S.3
Xiang, Y.4
Rongo, D.5
Tian, J.6
Hou, H.7
Zeng, J.8
Smith, A.9
Fan, S.10
Giunta, B.11
Mori, T.12
Currier, G.13
Shytle, D.R.14
Tan, J.15
-
55
-
-
33748752882
-
The roles of cyclindependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
-
Plattner F, Angelo M, Giese KP (2006) The roles of cyclindependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J Biol Chem 281, 25457-25465.
-
(2006)
J Biol Chem
, vol.281
, pp. 25457-25465
-
-
Plattner, F.1
Angelo, M.2
Giese, K.P.3
-
56
-
-
0027255817
-
Glycogen synthase kinase 3 beta is identical to tau protein kinase i generating several epitopes of paired helical filaments
-
Ishiguro K, Shiratsuchi A, Sato S, Omori A, Arioka M, Kobayashi S, Uchida T, Imahori K (1993) Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett 325, 167-172.
-
(1993)
FEBS Lett
, vol.325
, pp. 167-172
-
-
Ishiguro, K.1
Shiratsuchi, A.2
Sato, S.3
Omori, A.4
Arioka, M.5
Kobayashi, S.6
Uchida, T.7
Imahori, K.8
-
57
-
-
1842610852
-
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5
-
Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R (2004) Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci 24, 3370-3378.
-
(2004)
J Neurosci
, vol.24
, pp. 3370-3378
-
-
Wang, Q.1
Walsh, D.M.2
Rowan, M.J.3
Selkoe, D.J.4
Anwyl, R.5
-
58
-
-
33947519211
-
Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers
-
Butler D, Bendiske J, Michaelis ML, Karanian DA, Bahr BA (2007) Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers. Eur J Pharmacol 562, 20-27.
-
(2007)
Eur J Pharmacol
, vol.562
, pp. 20-27
-
-
Butler, D.1
Bendiske, J.2
Michaelis, M.L.3
Karanian, D.A.4
Bahr, B.A.5
-
59
-
-
84875655895
-
Inflammation in Alzheimer disease-A brief review of the basic science and clinical literature
-
Wyss-Coray T, Rogers J (2012) Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2, a006346.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, pp. a006346
-
-
Wyss-Coray, T.1
Rogers, J.2
-
60
-
-
84994727922
-
Glycogen synthase kinase-3beta regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: Implications for Alzheimer's disease
-
Fuster-Matanzo A, Jurado-Arjona J, Benvegnu S, Garcia E, Martin-Maestro P, Gomez-Sintes R, Hernandez F, Avila J (2017) Glycogen synthase kinase-3beta regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: Implications for Alzheimer's disease. Cell Mol Life Sci 74, 1153-1163.
-
(2017)
Cell Mol Life Sci
, vol.74
, pp. 1153-1163
-
-
Fuster-Matanzo, A.1
Jurado-Arjona, J.2
Benvegnu, S.3
Garcia, E.4
Martin-Maestro, P.5
Gomez-Sintes, R.6
Hernandez, F.7
Avila, J.8
-
61
-
-
85062594526
-
The role of astroglia in Alzheimer's disease: Pathophysiology and clinical implications
-
Arranz AM, De Strooper B (2019) The role of astroglia in Alzheimer's disease: Pathophysiology and clinical implications. Lancet Neurol 18, 406-414.
-
(2019)
Lancet Neurol
, vol.18
, pp. 406-414
-
-
Arranz, A.M.1
De Strooper, B.2
-
62
-
-
84890552198
-
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments
-
King MK, Pardo M, Cheng Y, Downey K, Jope RS, Beurel E (2014) Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments. Pharmacol Ther 141, 1-12.
-
(2014)
Pharmacol Ther
, vol.141
, pp. 1-12
-
-
King, M.K.1
Pardo, M.2
Cheng, Y.3
Downey, K.4
Jope, R.S.5
Beurel, E.6
-
63
-
-
80052658723
-
Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment
-
Martinez A, Gil C, Perez DI (2011) Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment. Int J Alzheimers Dis 2011, 280502.
-
(2011)
Int J Alzheimers Dis
, vol.2011
, pp. 280502
-
-
Martinez, A.1
Gil, C.2
Perez, D.I.3
-
64
-
-
1642363745
-
Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments
-
Hernandez F, Borrell J, Guaza C, Avila J, Lucas JJ (2002) Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments. J Neurochem 83, 1529-1533.
-
(2002)
J Neurochem
, vol.83
, pp. 1529-1533
-
-
Hernandez, F.1
Borrell, J.2
Guaza, C.3
Avila, J.4
Lucas, J.J.5
-
65
-
-
0035863188
-
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
-
Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J (2001) Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20, 27-39.
-
(2001)
EMBO J
, vol.20
, pp. 27-39
-
-
Lucas, J.J.1
Hernandez, F.2
Gomez-Ramos, P.3
Moran, M.A.4
Hen, R.5
Avila, J.6
-
66
-
-
33845530335
-
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert
-
Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F (2006) Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J Neurochem 99, 1445-1455.
-
(2006)
J Neurochem
, vol.99
, pp. 1445-1455
-
-
Engel, T.1
Goni-Oliver, P.2
Lucas, J.J.3
Avila, J.4
Hernandez, F.5
-
67
-
-
33646922314
-
Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
-
Engel T, Hernandez F, Avila J, Lucas JJ (2006) Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J Neurosci 26, 5083-5090.
-
(2006)
J Neurosci
, vol.26
, pp. 5083-5090
-
-
Engel, T.1
Hernandez, F.2
Avila, J.3
Lucas, J.J.4
-
68
-
-
75949107662
-
Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits
-
Gomez de Barreda E, Perez M, Gomez Ramos P, de Cristobal J, Martin-Maestro P, Moran A, Dawson HN, Vitek MP, Lucas JJ, Hernandez F, Avila J (2010) Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis 37, 622-629.
-
(2010)
Neurobiol Dis
, vol.37
, pp. 622-629
-
-
Gomez De Barreda, E.1
Perez, M.2
Gomez Ramos, P.3
De Cristobal, J.4
Martin-Maestro, P.5
Moran, A.6
Dawson, H.N.7
Vitek, M.P.8
Lucas, J.J.9
Hernandez, F.10
Avila, J.11
-
69
-
-
28844481487
-
Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies
-
Nakashima H, Ishihara T, Suguimoto P, Yokota O, Oshima E, Kugo A, Terada S, Hamamura T, Trojanowski JQ, Lee VM-Y, Kuroda S (2005) Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. Acta Neuropathol 110, 547-556.
-
(2005)
Acta Neuropathol
, vol.110
, pp. 547-556
-
-
Nakashima, H.1
Ishihara, T.2
Suguimoto, P.3
Yokota, O.4
Oshima, E.5
Kugo, A.6
Terada, S.7
Hamamura, T.8
Trojanowski, J.Q.9
Lee, V.M.-Y.10
Kuroda, S.11
-
70
-
-
21044449225
-
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
-
Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Lewis J, Dickson D, Duff K (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A 102, 6990-6995.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 6990-6995
-
-
Noble, W.1
Planel, E.2
Zehr, C.3
Olm, V.4
Meyerson, J.5
Suleman, F.6
Gaynor, K.7
Wang, L.8
LaFrancois, J.9
Feinstein, B.10
Burns, M.11
Krishnamurthy, P.12
Wen, Y.13
Bhat, R.14
Lewis, J.15
Dickson, D.16
Duff, K.17
-
71
-
-
0242720372
-
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model
-
Perez M, Hernandez F, Lim F, Diaz-Nido J, Avila J (2003) Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. J Alzheimers Dis 5, 301-308.
-
(2003)
J Alzheimers Dis
, vol.5
, pp. 301-308
-
-
Perez, M.1
Hernandez, F.2
Lim, F.3
Diaz-Nido, J.4
Avila, J.5
-
72
-
-
84863057878
-
Lithium treatment of APPSwDI/NOS2-/-mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype
-
Sudduth TL, Wilson JG, Everhart A, Colton CA, Wilcock DM (2012) Lithium treatment of APPSwDI/NOS2-/-mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS One 7, e31993.
-
(2012)
PLoS One
, vol.7
-
-
Sudduth, T.L.1
Wilson, J.G.2
Everhart, A.3
Colton, C.A.4
Wilcock, D.M.5
-
73
-
-
84978100792
-
Lithium suppression of tau induces brain iron accumulation and neurodegeneration
-
Lei P, Ayton S, Appukuttan AT, Moon S, Duce JA, Volitakis I, Cherny R, Wood SJ, Greenough M, Berger G, Pantelis C, McGorry P, Yung A, Finkelstein DI, Bush AI (2017) Lithium suppression of tau induces brain iron accumulation and neurodegeneration. Mol Psychiatry 22, 396-406.
-
(2017)
Mol Psychiatry
, vol.22
, pp. 396-406
-
-
Lei, P.1
Ayton, S.2
Appukuttan, A.T.3
Moon, S.4
Duce, J.A.5
Volitakis, I.6
Cherny, R.7
Wood, S.J.8
Greenough, M.9
Berger, G.10
Pantelis, C.11
McGorry, P.12
Yung, A.13
Finkelstein, D.I.14
Bush, A.I.15
-
74
-
-
84964607437
-
GSK3beta overexpression in dentate gyrus neural precursor cells expands the progenitor pool and enhances memory skills
-
Jurado-Arjona J, Llorens-Martin M, Avila J, Hernandez F (2016) GSK3beta overexpression in dentate gyrus neural precursor cells expands the progenitor pool and enhances memory skills. J Biol Chem 291, 8199-8213.
-
(2016)
J Biol Chem
, vol.291
, pp. 8199-8213
-
-
Jurado-Arjona, J.1
Llorens-Martin, M.2
Avila, J.3
Hernandez, F.4
-
75
-
-
85061007173
-
GSK3beta overexpression driven by GFAP promoter improves rotarod performance
-
Jurado-Arjona J, Rodriguez-Matellan A, Avila J, Hernandez F (2019) GSK3beta overexpression driven by GFAP promoter improves rotarod performance. Brain Res 1712, 47-54.
-
(2019)
Brain Res
, vol.1712
, pp. 47-54
-
-
Jurado-Arjona, J.1
Rodriguez-Matellan, A.2
Avila, J.3
Hernandez, F.4
-
76
-
-
84956961424
-
Chronic microdose lithium treatment prevented memory loss and neurohistopathological changes in a transgenic mouse model of Alzheimer's disease
-
Nunes MA, Schowe NM, Monteiro-Silva KC, Baraldi-Tornisielo T, Souza SIG, Balthazar J, Albuquerque MS, Caetano AL, Viel TA, Buck HS (2015) Chronic microdose lithium treatment prevented memory loss and neurohistopathological changes in a transgenic mouse model of Alzheimer's disease. PLoS One 10, e0142267.
-
(2015)
PLoS One
, vol.10
-
-
Nunes, M.A.1
Schowe, N.M.2
Monteiro-Silva, K.C.3
Baraldi-Tornisielo, T.4
Souza, S.I.G.5
Balthazar, J.6
Albuquerque, M.S.7
Caetano, A.L.8
Viel, T.A.9
Buck, H.S.10
-
77
-
-
85026783851
-
BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology
-
Wilson EN, Do Carmo S, Iulita MF, Hall H, Ducatenzeiler A, Marks AR, Allard S, Jia DT, Windheim J, Cuello AC (2017) BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology. Transl Psychiatry 7, e1190.
-
(2017)
Transl Psychiatry
, vol.7
, pp. e1190
-
-
Wilson, E.N.1
Do Carmo, S.2
Iulita, M.F.3
Hall, H.4
Ducatenzeiler, A.5
Marks, A.R.6
Allard, S.7
Jia, D.T.8
Windheim, J.9
Cuello, A.C.10
-
79
-
-
84875803609
-
Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta
-
Jing P, Zhang J-Y, Ouyang Q, Wu J, Zhang X-J (2013) Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta. Chem Biol Interact 203, 309-313.
-
(2013)
Chem Biol Interact
, vol.203
, pp. 309-313
-
-
Jing, P.1
Zhang, J.-Y.2
Ouyang, Q.3
Wu, J.4
Zhang, X.-J.5
-
80
-
-
85048969248
-
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease
-
Hampel H, Mesulam M-M, Cuello AC, Farlow MR, Giacobini E, Grossberg GT, Khachaturian AS, Vergallo A, Cavedo E, Snyder PJ, Khachaturian ZS (2018) The cholinergic system in the pathophysiology and treatment of Alzheimer's disease. Brain 141, 1917-1933.
-
(2018)
Brain
, vol.141
, pp. 1917-1933
-
-
Hampel, H.1
Mesulam, M.-M.2
Cuello, A.C.3
Farlow, M.R.4
Giacobini, E.5
Grossberg, G.T.6
Khachaturian, A.S.7
Vergallo, A.8
Cavedo, E.9
Snyder, P.J.10
Khachaturian, Z.S.11
-
81
-
-
84939985495
-
GSK-3beta dysregulation contributes to Parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and alpha-synuclein
-
Credle JJ, George JL, Wills J, Duka V, Shah K, Lee Y-C, Rodriguez O, Simkins T, Winter M, Moechars D, Steckler T, Goudreau J, Finkelstein DI, Sidhu A (2015) GSK-3beta dysregulation contributes to Parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and alpha-synuclein. Cell Death Differ 22, 838-851.
-
(2015)
Cell Death Differ
, vol.22
, pp. 838-851
-
-
Credle, J.J.1
George, J.L.2
Wills, J.3
Duka, V.4
Shah, K.5
Lee, Y.-C.6
Rodriguez, O.7
Simkins, T.8
Winter, M.9
Moechars, D.10
Steckler, T.11
Goudreau, J.12
Finkelstein, D.I.13
Sidhu, A.14
-
82
-
-
84899547628
-
Extracellular alpha-synuclein leads to microtubule destabilization via GSK-3beta-dependent Tau phosphorylation in PC12 cells
-
Gassowska M, Czapski GA, Pajak B, Cieslik M, Lenkiewicz AM, Adamczyk A (2014) Extracellular alpha-synuclein leads to microtubule destabilization via GSK-3beta-dependent Tau phosphorylation in PC12 cells. PLoS One 9, e94259.
-
(2014)
PLoS One
, vol.9
-
-
Gassowska, M.1
Czapski, G.A.2
Pajak, B.3
Cieslik, M.4
Lenkiewicz, A.M.5
Adamczyk, A.6
-
83
-
-
84867519558
-
Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with alpha-synuclein at the single molecule level
-
Nubling G, Bader B, Levin J, Hildebrandt J, Kretzschmar H, Giese A (2012) Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with alpha-synuclein at the single molecule level. Mol Neurodegener 7, 35.
-
(2012)
Mol Neurodegener
, vol.7
, pp. 35
-
-
Nubling, G.1
Bader, B.2
Levin, J.3
Hildebrandt, J.4
Kretzschmar, H.5
Giese, A.6
-
84
-
-
77951176737
-
Extending healthy life span-from yeast to humans
-
Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328, 321-326.
-
(2010)
Science
, vol.328
, pp. 321-326
-
-
Fontana, L.1
Partridge, L.2
Longo, V.D.3
-
85
-
-
84949555897
-
Cellular senescence in aging and age-related disease: From mechanisms to therapy
-
Childs BG, Durik M, Baker DJ, van Deursen JM (2015) Cellular senescence in aging and age-related disease: From mechanisms to therapy. Nat Med 21, 1424-1435.
-
(2015)
Nat Med
, vol.21
, pp. 1424-1435
-
-
Childs, B.G.1
Durik, M.2
Baker, D.J.3
Van Deursen, J.M.4
-
86
-
-
84863224067
-
Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot
-
Hampel H, Lista S, Khachaturian ZS (2012) Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot. Alzheimers Dement 8, 312-336.
-
(2012)
Alzheimers Dement
, vol.8
, pp. 312-336
-
-
Hampel, H.1
Lista, S.2
Khachaturian, Z.S.3
-
87
-
-
0036937699
-
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
-
Augustinack JC, Schneider A, Mandelkow E-M, Hyman BT (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol 103, 26-35.
-
(2002)
Acta Neuropathol
, vol.103
, pp. 26-35
-
-
Augustinack, J.C.1
Schneider, A.2
Mandelkow, E.-M.3
Hyman, B.T.4
-
88
-
-
33750510335
-
PKA modulates GSK-3betaand cdk5-catalyzed phosphorylation of tau in site-and kinase-specific manners
-
Liu F, Liang Z, Shi J, Yin D, El-Akkad E, Grundke-Iqbal I, Iqbal K, Gong C-X (2006) PKA modulates GSK-3betaand cdk5-catalyzed phosphorylation of tau in site-and kinase-specific manners. FEBS Lett 580, 6269-6274.
-
(2006)
FEBS Lett
, vol.580
, pp. 6269-6274
-
-
Liu, F.1
Liang, Z.2
Shi, J.3
Yin, D.4
El-Akkad, E.5
Grundke-Iqbal, I.6
Iqbal, K.7
Gong, C.-X.8
-
89
-
-
34548191034
-
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis
-
Hanger DP, Byers HL, Wray S, Leung K-Y, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH (2007) Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 282, 23645-23654.
-
(2007)
J Biol Chem
, vol.282
, pp. 23645-23654
-
-
Hanger, D.P.1
Byers, H.L.2
Wray, S.3
Leung, K.-Y.4
Saxton, M.J.5
Seereeram, A.6
Reynolds, C.H.7
Ward, M.A.8
Anderton, B.H.9
-
90
-
-
14044270858
-
Evidence that phosphorylation of the microtubuleassociated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly
-
Feijoo C, Campbell DG, Jakes R, Goedert M, Cuenda A (2005) Evidence that phosphorylation of the microtubuleassociated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly. J Cell Sci 118, 397-408.
-
(2005)
J Cell Sci
, vol.118
, pp. 397-408
-
-
Feijoo, C.1
Campbell, D.G.2
Jakes, R.3
Goedert, M.4
Cuenda, A.5
-
91
-
-
84924163148
-
A novel, ultrasensitive assay for tau: Potential for assessing traumatic brain injury in tissues and biofluids
-
Rubenstein R, Chang B, Davies P, Wagner AK, Robertson CS, Wang KKW (2015) A novel, ultrasensitive assay for tau: Potential for assessing traumatic brain injury in tissues and biofluids. J Neurotrauma 32, 342-352.
-
(2015)
J Neurotrauma
, vol.32
, pp. 342-352
-
-
Rubenstein, R.1
Chang, B.2
Davies, P.3
Wagner, A.K.4
Robertson, C.S.5
Wang, K.K.W.6
-
92
-
-
85042407518
-
Relevance of phosphorylation and truncation of tau to the etiopathogenesis of Alzheimer's disease
-
Zhou Y, Shi J, Chu D, HuW, Guan Z, Gong C-X, Iqbal K, Liu F (2018) Relevance of phosphorylation and truncation of tau to the etiopathogenesis of Alzheimer's disease.Front Aging Neurosci 10, 27.
-
(2018)
Front Aging Neurosci
, vol.10
, pp. 27
-
-
Zhou, Y.1
Shi, J.2
Chu, D.3
Hu, W.4
Guan, Z.5
Gong, C.-X.6
Iqbal, K.7
Liu, F.8
-
93
-
-
84922576117
-
Pseudophosphorylation of tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein tau to dendritic spines
-
Xia D, Li C, Gotz J (2015) Pseudophosphorylation of tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein tau to dendritic spines. Biochim Biophys Acta 1852, 913-924.
-
(2015)
Biochim Biophys Acta
, vol.1852
, pp. 913-924
-
-
Xia, D.1
Li, C.2
Gotz, J.3
-
94
-
-
84963805081
-
FLEXITau: Quantifying post-translational modifications of tau protein in vitro and in human disease
-
Mair W, Muntel J, Tepper K, Tang S, Biernat J, Seeley WW, Kosik KS, Mandelkow E, Steen H, Steen JA (2016) FLEXITau: Quantifying post-translational modifications of tau protein in vitro and in human disease. Anal Chem 88, 3704-3714.
-
(2016)
Anal Chem
, vol.88
, pp. 3704-3714
-
-
Mair, W.1
Muntel, J.2
Tepper, K.3
Tang, S.4
Biernat, J.5
Seeley, W.W.6
Kosik, K.S.7
Mandelkow, E.8
Steen, H.9
Steen, J.A.10
-
95
-
-
0035066999
-
Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231
-
Hampel H, Buerger K, Kohnken R, Teipel SJ, Zinkowski R, Moeller HJ, Rapoport SI, Davies P (2001) Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Ann Neurol 49, 545-546.
-
(2001)
Ann Neurol
, vol.49
, pp. 545-546
-
-
Hampel, H.1
Buerger, K.2
Kohnken, R.3
Teipel, S.J.4
Zinkowski, R.5
Moeller, H.J.6
Rapoport, S.I.7
Davies, P.8
-
96
-
-
84938421302
-
Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice
-
Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L (2015) Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice. Nat Neurosci 18, 1183-1189.
-
(2015)
Nat Neurosci
, vol.18
, pp. 1183-1189
-
-
Morris, M.1
Knudsen, G.M.2
Maeda, S.3
Trinidad, J.C.4
Ioanoviciu, A.5
Burlingame, A.L.6
Mucke, L.7
-
97
-
-
33750589818
-
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
-
Buerger K, Ewers M, Pirttila T, Zinkowski R, Alafuzoff I, Teipel SJ, DeBernardis J, Kerkman D, McCulloch C, Soininen H, Hampel H (2006) CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain 129, 3035-3041.
-
(2006)
Brain
, vol.129
, pp. 3035-3041
-
-
Buerger, K.1
Ewers, M.2
Pirttila, T.3
Zinkowski, R.4
Alafuzoff, I.5
Teipel, S.J.6
DeBernardis, J.7
Kerkman, D.8
McCulloch, C.9
Soininen, H.10
Hampel, H.11
-
98
-
-
85041400134
-
A mathematical model of multisite phosphorylation of tau protein
-
Stepanov A, Karelina T, Markevich N, Demin O, Nicholas T (2018) A mathematical model of multisite phosphorylation of tau protein. PLoS One 13, e0192519.
-
(2018)
PLoS One
, vol.13
-
-
Stepanov, A.1
Karelina, T.2
Markevich, N.3
Demin, O.4
Nicholas, T.5
-
99
-
-
9644257211
-
Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain
-
Liu SJ, Zhang JY, Li HL, Fang ZY, Wang Q, Deng HM, Gong CX, Grundke-Iqbal I, Iqbal K, Wang JZ (2004) Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 279, 50078-50088.
-
(2004)
J Biol Chem
, vol.279
, pp. 50078-50088
-
-
Liu, S.J.1
Zhang, J.Y.2
Li, H.L.3
Fang, Z.Y.4
Wang, Q.5
Deng, H.M.6
Gong, C.X.7
Grundke-Iqbal, I.8
Iqbal, K.9
Wang, J.Z.10
-
100
-
-
84860373672
-
FLEXIQinase, a mass spectrometrybased assay, to unveil multikinase mechanisms
-
Singh SA, Winter D, Bilimoria PM, Bonni A, Steen H, Steen JA (2012) FLEXIQinase, a mass spectrometrybased assay, to unveil multikinase mechanisms. Nat Methods 9, 504-508.
-
(2012)
Nat Methods
, vol.9
, pp. 504-508
-
-
Singh, S.A.1
Winter, D.2
Bilimoria, P.M.3
Bonni, A.4
Steen, H.5
Steen, J.A.6
-
101
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong C-X (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22, 1942-1950.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.-X.4
-
102
-
-
84878760670
-
Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development
-
Geerts H, Spiros A, Roberts P, Carr R (2013) Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development. J Pharmacokinet Pharmacodyn 40, 257-265.
-
(2013)
J Pharmacokinet Pharmacodyn
, vol.40
, pp. 257-265
-
-
Geerts, H.1
Spiros, A.2
Roberts, P.3
Carr, R.4
-
103
-
-
85041613843
-
Impact of amyloidbeta changes on cognitive outcomes in Alzheimer's disease: Analysis of clinical trials using a quantitative systems pharmacology model
-
Geerts H, Spiros A, Roberts P (2018) Impact of amyloidbeta changes on cognitive outcomes in Alzheimer's disease: Analysis of clinical trials using a quantitative systems pharmacology model. Alzheimers Res Ther 10, 14.
-
(2018)
Alzheimers Res Ther
, vol.10
, pp. 14
-
-
Geerts, H.1
Spiros, A.2
Roberts, P.3
-
104
-
-
77954239263
-
Biomarkers for Alzheimer's disease: Academic, industry and regulatory perspectives
-
Hampel H, Frank R, Broich K, Teipel SJ, Katz RG, Hardy J, Herholz K, Bokde ALW, Jessen F, Hoessler YC, Sanhai WR, Zetterberg H, Woodcock J, Blennow K (2010) Biomarkers for Alzheimer's disease: Academic, industry and regulatory perspectives. Nat Rev Drug Discov 9, 560-574.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 560-574
-
-
Hampel, H.1
Frank, R.2
Broich, K.3
Teipel, S.J.4
Katz, R.G.5
Hardy, J.6
Herholz, K.7
Bokde, A.L.W.8
Jessen, F.9
Hoessler, Y.C.10
Sanhai, W.R.11
Zetterberg, H.12
Woodcock, J.13
Blennow, K.14
|