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Volumn 69, Issue 3, 2019, Pages 615-629

Lithium as a Treatment for Alzheimer's Disease: The Systems Pharmacology Perspective

Author keywords

Alzheimer's disease; GSK3; lithium; neurotoxicity; post translational modification; precision medicine; systems pharmacology; tau

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; LITHIUM CHLORIDE; TRANQUILIZER;

EID: 85067111942     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-190197     Document Type: Review
Times cited : (52)

References (104)
  • 2
    • 84994464103 scopus 로고    scopus 로고
    • Network abnormalities and interneuron dysfunction in Alzheimer disease
    • Palop JJ, Mucke L (2016) Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci 17, 777.
    • (2016) Nat Rev Neurosci , vol.17 , pp. 777
    • Palop, J.J.1    Mucke, L.2
  • 3
    • 85060085145 scopus 로고    scopus 로고
    • Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis
    • Henstridge CM, Hyman BT, Spires-Jones TL (2019) Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nat Rev Neurosci 20, 94-108.
    • (2019) Nat Rev Neurosci , vol.20 , pp. 94-108
    • Henstridge, C.M.1    Hyman, B.T.2    Spires-Jones, T.L.3
  • 4
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • Hoeijmakers JHJ (2009) DNA damage, aging, and cancer. N Engl J Med 361, 1475-1485.
    • (2009) N Engl J Med , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.J.1
  • 6
    • 85061755242 scopus 로고    scopus 로고
    • Treatment combinations for Alzheimer's disease: Current and future pharmacotherapy options
    • Cummings JL, Tong G, Ballard C (2019) Treatment combinations for Alzheimer's disease: Current and future pharmacotherapy options. J Alzheimers Dis 67, 779-794.
    • (2019) J Alzheimers Dis , vol.67 , pp. 779-794
    • Cummings, J.L.1    Tong, G.2    Ballard, C.3
  • 7
    • 84869878419 scopus 로고    scopus 로고
    • Simulations of symptomatic treatments for Alzheimer's disease: Computational analysis of pathology and mechanisms of drug action
    • Roberts PD, Spiros A, Geerts H (2012) Simulations of symptomatic treatments for Alzheimer's disease: Computational analysis of pathology and mechanisms of drug action. Alzheimers Res Ther 4, 50.
    • (2012) Alzheimers Res Ther , vol.4 , pp. 50
    • Roberts, P.D.1    Spiros, A.2    Geerts, H.3
  • 8
    • 84888011244 scopus 로고    scopus 로고
    • Networkbased approaches in drug discovery and early development
    • Harrold JM, Ramanathan M, Mager DE (2013) Networkbased approaches in drug discovery and early development. Clin Pharmacol Ther 94, 651-658.
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 651-658
    • Harrold, J.M.1    Ramanathan, M.2    Mager, D.E.3
  • 11
    • 84855906454 scopus 로고    scopus 로고
    • Systems pharmacology: Network analysis to identify multiscale mechanisms of drug action
    • Zhao S, Iyengar R (2012) Systems pharmacology: Network analysis to identify multiscale mechanisms of drug action. Annu Rev Pharmacol Toxicol 52, 505-521.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 505-521
    • Zhao, S.1    Iyengar, R.2
  • 14
    • 85006626463 scopus 로고    scopus 로고
    • Cancer precision medicine: From cancer screening to drug selection and personalized immunotherapy
    • Deng X, Nakamura Y (2017) Cancer precision medicine: From cancer screening to drug selection and personalized immunotherapy. Trends Pharmacol Sci 38, 15-24.
    • (2017) Trends Pharmacol Sci , vol.38 , pp. 15-24
    • Deng, X.1    Nakamura, Y.2
  • 15
    • 84901626678 scopus 로고    scopus 로고
    • Genomicsenabled drug repositioning and repurposing: Insights from an IOM Roundtable activity
    • Power A, Berger AC, Ginsburg GS (2014) Genomicsenabled drug repositioning and repurposing: Insights from an IOM Roundtable activity. JAMA 311, 2063-2064.
    • (2014) JAMA , vol.311 , pp. 2063-2064
    • Power, A.1    Berger, A.C.2    Ginsburg, G.S.3
  • 19
    • 80052749028 scopus 로고    scopus 로고
    • Divergent network connectivity changes in healthy APOE epsilon4 carriers: Disinhibition or compensation?
    • Seeley WW (2011) Divergent network connectivity changes in healthy APOE epsilon4 carriers: Disinhibition or compensation? Arch Neurol 68, 1107-1108.
    • (2011) Arch Neurol , vol.68 , pp. 1107-1108
    • Seeley, W.W.1
  • 21
    • 84929948919 scopus 로고    scopus 로고
    • Lithium in the treatment of bipolar disorder: Pharmacology and pharmacogenetics
    • Alda M (2015) Lithium in the treatment of bipolar disorder: Pharmacology and pharmacogenetics. Mol Psychiatry 20, 661-670.
    • (2015) Mol Psychiatry , vol.20 , pp. 661-670
    • Alda, M.1
  • 22
    • 84941278298 scopus 로고    scopus 로고
    • Lithium as a treatment for Alzheimer's disease: A systematic review and meta-analysis
    • Matsunaga S, Kishi T, Annas P, Basun H, Hampel H, Iwata N (2015) Lithium as a treatment for Alzheimer's disease: A systematic review and meta-analysis. J Alzheimers Dis 48, 403-410.
    • (2015) J Alzheimers Dis , vol.48 , pp. 403-410
    • Matsunaga, S.1    Kishi, T.2    Annas, P.3    Basun, H.4    Hampel, H.5    Iwata, N.6
  • 24
    • 67649199941 scopus 로고    scopus 로고
    • Can lithium or valproate untie tangles in Alzheimer's disease?
    • Tariot PN, Aisen PS (2009) Can lithium or valproate untie tangles in Alzheimer's disease? J Clin Psychiatry 70, 919-921.
    • (2009) J Clin Psychiatry , vol.70 , pp. 919-921
    • Tariot, P.N.1    Aisen, P.S.2
  • 25
    • 84975764391 scopus 로고    scopus 로고
    • Lithium, a therapy for AD: Current evidence from clinical trials of neurodegenerative disorders
    • Forlenza OV, Aprahamian I, de Paula VJ, Hajek T (2016) Lithium, a therapy for AD: Current evidence from clinical trials of neurodegenerative disorders. Curr Alzheimer Res 13, 879-886.
    • (2016) Curr Alzheimer Res , vol.13 , pp. 879-886
    • Forlenza, O.V.1    Aprahamian, I.2    De Paula, V.J.3    Hajek, T.4
  • 26
    • 85054875049 scopus 로고    scopus 로고
    • Molecular mechanisms of lithium action: Switching the light on multiple targets for dementia using animal models
    • Kerr F, Bjedov I, Sofola-Adesakin O (2018) Molecular mechanisms of lithium action: Switching the light on multiple targets for dementia using animal models. Front Mol Neurosci 11, 297.
    • (2018) Front Mol Neurosci , vol.11 , pp. 297
    • Kerr, F.1    Bjedov, I.2    Sofola-Adesakin, O.3
  • 27
    • 84856702223 scopus 로고    scopus 로고
    • Inhibition of GSK3 by lithium, from single molecules to signaling networks
    • Freland L, Beaulieu J-M (2012) Inhibition of GSK3 by lithium, from single molecules to signaling networks. Front Mol Neurosci 5, 14.
    • (2012) Front Mol Neurosci , vol.5 , pp. 14
    • Freland, L.1    Beaulieu, J.-M.2
  • 28
    • 84888205849 scopus 로고    scopus 로고
    • Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid
    • Braak H, Zetterberg H, Del Tredici K, Blennow K (2013) Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-beta changes occur before increases of tau in cerebrospinal fluid. Acta Neuropathol 126, 631-641.
    • (2013) Acta Neuropathol , vol.126 , pp. 631-641
    • Braak, H.1    Zetterberg, H.2    Del Tredici, K.3    Blennow, K.4
  • 29
    • 85059560378 scopus 로고    scopus 로고
    • Acritical appraisal of amyloid-beta-targeting therapies for Alzheimer disease
    • Panza F, Lozupone M, Logroscino G, Imbimbo BP (2019) Acritical appraisal of amyloid-beta-targeting therapies for Alzheimer disease. Nat Rev Neurol 15, 73-88.
    • (2019) Nat Rev Neurol , vol.15 , pp. 73-88
    • Panza, F.1    Lozupone, M.2    Logroscino, G.3    Imbimbo, B.P.4
  • 30
    • 85027585635 scopus 로고    scopus 로고
    • Amyloid in Alzheimer's disease: Guilty beyond reasonable doubt?
    • Behl C (2017) Amyloid in Alzheimer's disease: Guilty beyond reasonable doubt? Trends Pharmacol Sci 38, 849-851.
    • (2017) Trends Pharmacol Sci , vol.38 , pp. 849-851
    • Behl, C.1
  • 31
    • 85048357589 scopus 로고    scopus 로고
    • Tau-targeting therapies for Alzheimer disease
    • Congdon EE, Sigurdsson EM (2018) Tau-targeting therapies for Alzheimer disease. Nat Rev Neurol 14, 399-415.
    • (2018) Nat Rev Neurol , vol.14 , pp. 399-415
    • Congdon, E.E.1    Sigurdsson, E.M.2
  • 34
    • 85039966225 scopus 로고    scopus 로고
    • Lithium, stress, and resilience in bipolar disorder: Deciphering this key homeostatic synaptic plasticity regulator
    • Machado-Vieira R (2018) Lithium, stress, and resilience in bipolar disorder: Deciphering this key homeostatic synaptic plasticity regulator. J Affect Disord 233, 92-99.
    • (2018) J Affect Disord , vol.233 , pp. 92-99
    • Machado-Vieira, R.1
  • 36
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 39
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend M, Mehta T, Selkoe DJ (2007) Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 282, 33305-33312.
    • (2007) J Biol Chem , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 41
    • 39849110726 scopus 로고    scopus 로고
    • The GSK3 hypothesis of Alzheimer's disease
    • Hooper C, Killick R, Lovestone S (2008) The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104, 1433-1439.
    • (2008) J Neurochem , vol.104 , pp. 1433-1439
    • Hooper, C.1    Killick, R.2    Lovestone, S.3
  • 42
    • 3343005434 scopus 로고    scopus 로고
    • PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations
    • Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: Effects of FAD mutations. EMBO J 23, 2586-2596.
    • (2004) EMBO J , vol.23 , pp. 2586-2596
    • Baki, L.1    Shioi, J.2    Wen, P.3    Shao, Z.4    Schwarzman, A.5    Gama-Sosa, M.6    Neve, R.7    Robakis, N.K.8
  • 44
    • 84872587279 scopus 로고    scopus 로고
    • GSK3 and tau: Two convergence points in Alzheimer's disease
    • Hernandez F, Lucas JJ, Avila J (2013) GSK3 and tau: Two convergence points in Alzheimer's disease. J Alzheimers Dis 33(Suppl 1), S141-144.
    • (2013) J Alzheimers Dis , vol.33 , pp. S141-S144
    • Hernandez, F.1    Lucas, J.J.2    Avila, J.3
  • 46
    • 3042558276 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A drug target for CNS therapies
    • Bhat R V, Budd Haeberlein SL, Avila J (2004) Glycogen synthase kinase 3: A drug target for CNS therapies. J Neurochem 89, 1313-1317.
    • (2004) J Neurochem , vol.89 , pp. 1313-1317
    • Bhat, R.V.1    Budd Haeberlein, S.L.2    Avila, J.3
  • 47
    • 33947597084 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics
    • Jope RS, Yuskaitis CJ, Beurel E (2007) Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics. Neurochem Res 32, 577-595.
    • (2007) Neurochem Res , vol.32 , pp. 577-595
    • Jope, R.S.1    Yuskaitis, C.J.2    Beurel, E.3
  • 52
    • 84993973237 scopus 로고    scopus 로고
    • Stereological investigation of theCA1pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice
    • Schaeffer EL, Catanozi S, West MJ, Gattaz WF (2017) Stereological investigation of theCA1pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice. Ann Anat 209, 51-60.
    • (2017) Ann Anat , vol.209 , pp. 51-60
    • Schaeffer, E.L.1    Catanozi, S.2    West, M.J.3    Gattaz, W.F.4
  • 53
    • 79959276349 scopus 로고    scopus 로고
    • Long-term treatment with lithium alleviates memory deficits and reduces amyloid-beta production in an aged Alzheimer's disease transgenic mouse model
    • Zhang X, Heng X, Li T, Li L, Yang D, Zhang X, Du Y, Doody RS, Le W (2011) Long-term treatment with lithium alleviates memory deficits and reduces amyloid-beta production in an aged Alzheimer's disease transgenic mouse model. J Alzheimers Dis 24, 739-749.
    • (2011) J Alzheimers Dis , vol.24 , pp. 739-749
    • Zhang, X.1    Heng, X.2    Li, T.3    Li, L.4    Yang, D.5    Zhang, X.6    Du, Y.7    Doody, R.S.8    Le, W.9
  • 55
    • 33748752882 scopus 로고    scopus 로고
    • The roles of cyclindependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
    • Plattner F, Angelo M, Giese KP (2006) The roles of cyclindependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. J Biol Chem 281, 25457-25465.
    • (2006) J Biol Chem , vol.281 , pp. 25457-25465
    • Plattner, F.1    Angelo, M.2    Giese, K.P.3
  • 56
    • 0027255817 scopus 로고
    • Glycogen synthase kinase 3 beta is identical to tau protein kinase i generating several epitopes of paired helical filaments
    • Ishiguro K, Shiratsuchi A, Sato S, Omori A, Arioka M, Kobayashi S, Uchida T, Imahori K (1993) Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett 325, 167-172.
    • (1993) FEBS Lett , vol.325 , pp. 167-172
    • Ishiguro, K.1    Shiratsuchi, A.2    Sato, S.3    Omori, A.4    Arioka, M.5    Kobayashi, S.6    Uchida, T.7    Imahori, K.8
  • 57
    • 1842610852 scopus 로고    scopus 로고
    • Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5
    • Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R (2004) Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci 24, 3370-3378.
    • (2004) J Neurosci , vol.24 , pp. 3370-3378
    • Wang, Q.1    Walsh, D.M.2    Rowan, M.J.3    Selkoe, D.J.4    Anwyl, R.5
  • 58
    • 33947519211 scopus 로고    scopus 로고
    • Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers
    • Butler D, Bendiske J, Michaelis ML, Karanian DA, Bahr BA (2007) Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers. Eur J Pharmacol 562, 20-27.
    • (2007) Eur J Pharmacol , vol.562 , pp. 20-27
    • Butler, D.1    Bendiske, J.2    Michaelis, M.L.3    Karanian, D.A.4    Bahr, B.A.5
  • 59
    • 84875655895 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease-A brief review of the basic science and clinical literature
    • Wyss-Coray T, Rogers J (2012) Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb Perspect Med 2, a006346.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a006346
    • Wyss-Coray, T.1    Rogers, J.2
  • 60
    • 84994727922 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: Implications for Alzheimer's disease
    • Fuster-Matanzo A, Jurado-Arjona J, Benvegnu S, Garcia E, Martin-Maestro P, Gomez-Sintes R, Hernandez F, Avila J (2017) Glycogen synthase kinase-3beta regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: Implications for Alzheimer's disease. Cell Mol Life Sci 74, 1153-1163.
    • (2017) Cell Mol Life Sci , vol.74 , pp. 1153-1163
    • Fuster-Matanzo, A.1    Jurado-Arjona, J.2    Benvegnu, S.3    Garcia, E.4    Martin-Maestro, P.5    Gomez-Sintes, R.6    Hernandez, F.7    Avila, J.8
  • 61
    • 85062594526 scopus 로고    scopus 로고
    • The role of astroglia in Alzheimer's disease: Pathophysiology and clinical implications
    • Arranz AM, De Strooper B (2019) The role of astroglia in Alzheimer's disease: Pathophysiology and clinical implications. Lancet Neurol 18, 406-414.
    • (2019) Lancet Neurol , vol.18 , pp. 406-414
    • Arranz, A.M.1    De Strooper, B.2
  • 63
    • 80052658723 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment
    • Martinez A, Gil C, Perez DI (2011) Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment. Int J Alzheimers Dis 2011, 280502.
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 280502
    • Martinez, A.1    Gil, C.2    Perez, D.I.3
  • 64
    • 1642363745 scopus 로고    scopus 로고
    • Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments
    • Hernandez F, Borrell J, Guaza C, Avila J, Lucas JJ (2002) Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments. J Neurochem 83, 1529-1533.
    • (2002) J Neurochem , vol.83 , pp. 1529-1533
    • Hernandez, F.1    Borrell, J.2    Guaza, C.3    Avila, J.4    Lucas, J.J.5
  • 65
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J (2001) Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20, 27-39.
    • (2001) EMBO J , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 66
    • 33845530335 scopus 로고    scopus 로고
    • Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert
    • Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F (2006) Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J Neurochem 99, 1445-1455.
    • (2006) J Neurochem , vol.99 , pp. 1445-1455
    • Engel, T.1    Goni-Oliver, P.2    Lucas, J.J.3    Avila, J.4    Hernandez, F.5
  • 67
    • 33646922314 scopus 로고    scopus 로고
    • Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
    • Engel T, Hernandez F, Avila J, Lucas JJ (2006) Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J Neurosci 26, 5083-5090.
    • (2006) J Neurosci , vol.26 , pp. 5083-5090
    • Engel, T.1    Hernandez, F.2    Avila, J.3    Lucas, J.J.4
  • 71
    • 0242720372 scopus 로고    scopus 로고
    • Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model
    • Perez M, Hernandez F, Lim F, Diaz-Nido J, Avila J (2003) Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. J Alzheimers Dis 5, 301-308.
    • (2003) J Alzheimers Dis , vol.5 , pp. 301-308
    • Perez, M.1    Hernandez, F.2    Lim, F.3    Diaz-Nido, J.4    Avila, J.5
  • 72
    • 84863057878 scopus 로고    scopus 로고
    • Lithium treatment of APPSwDI/NOS2-/-mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype
    • Sudduth TL, Wilson JG, Everhart A, Colton CA, Wilcock DM (2012) Lithium treatment of APPSwDI/NOS2-/-mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS One 7, e31993.
    • (2012) PLoS One , vol.7
    • Sudduth, T.L.1    Wilson, J.G.2    Everhart, A.3    Colton, C.A.4    Wilcock, D.M.5
  • 74
    • 84964607437 scopus 로고    scopus 로고
    • GSK3beta overexpression in dentate gyrus neural precursor cells expands the progenitor pool and enhances memory skills
    • Jurado-Arjona J, Llorens-Martin M, Avila J, Hernandez F (2016) GSK3beta overexpression in dentate gyrus neural precursor cells expands the progenitor pool and enhances memory skills. J Biol Chem 291, 8199-8213.
    • (2016) J Biol Chem , vol.291 , pp. 8199-8213
    • Jurado-Arjona, J.1    Llorens-Martin, M.2    Avila, J.3    Hernandez, F.4
  • 75
    • 85061007173 scopus 로고    scopus 로고
    • GSK3beta overexpression driven by GFAP promoter improves rotarod performance
    • Jurado-Arjona J, Rodriguez-Matellan A, Avila J, Hernandez F (2019) GSK3beta overexpression driven by GFAP promoter improves rotarod performance. Brain Res 1712, 47-54.
    • (2019) Brain Res , vol.1712 , pp. 47-54
    • Jurado-Arjona, J.1    Rodriguez-Matellan, A.2    Avila, J.3    Hernandez, F.4
  • 79
    • 84875803609 scopus 로고    scopus 로고
    • Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta
    • Jing P, Zhang J-Y, Ouyang Q, Wu J, Zhang X-J (2013) Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta. Chem Biol Interact 203, 309-313.
    • (2013) Chem Biol Interact , vol.203 , pp. 309-313
    • Jing, P.1    Zhang, J.-Y.2    Ouyang, Q.3    Wu, J.4    Zhang, X.-J.5
  • 82
    • 84899547628 scopus 로고    scopus 로고
    • Extracellular alpha-synuclein leads to microtubule destabilization via GSK-3beta-dependent Tau phosphorylation in PC12 cells
    • Gassowska M, Czapski GA, Pajak B, Cieslik M, Lenkiewicz AM, Adamczyk A (2014) Extracellular alpha-synuclein leads to microtubule destabilization via GSK-3beta-dependent Tau phosphorylation in PC12 cells. PLoS One 9, e94259.
    • (2014) PLoS One , vol.9
    • Gassowska, M.1    Czapski, G.A.2    Pajak, B.3    Cieslik, M.4    Lenkiewicz, A.M.5    Adamczyk, A.6
  • 83
    • 84867519558 scopus 로고    scopus 로고
    • Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with alpha-synuclein at the single molecule level
    • Nubling G, Bader B, Levin J, Hildebrandt J, Kretzschmar H, Giese A (2012) Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with alpha-synuclein at the single molecule level. Mol Neurodegener 7, 35.
    • (2012) Mol Neurodegener , vol.7 , pp. 35
    • Nubling, G.1    Bader, B.2    Levin, J.3    Hildebrandt, J.4    Kretzschmar, H.5    Giese, A.6
  • 84
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-from yeast to humans
    • Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328, 321-326.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 85
    • 84949555897 scopus 로고    scopus 로고
    • Cellular senescence in aging and age-related disease: From mechanisms to therapy
    • Childs BG, Durik M, Baker DJ, van Deursen JM (2015) Cellular senescence in aging and age-related disease: From mechanisms to therapy. Nat Med 21, 1424-1435.
    • (2015) Nat Med , vol.21 , pp. 1424-1435
    • Childs, B.G.1    Durik, M.2    Baker, D.J.3    Van Deursen, J.M.4
  • 86
    • 84863224067 scopus 로고    scopus 로고
    • Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot
    • Hampel H, Lista S, Khachaturian ZS (2012) Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot. Alzheimers Dement 8, 312-336.
    • (2012) Alzheimers Dement , vol.8 , pp. 312-336
    • Hampel, H.1    Lista, S.2    Khachaturian, Z.S.3
  • 87
    • 0036937699 scopus 로고    scopus 로고
    • Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
    • Augustinack JC, Schneider A, Mandelkow E-M, Hyman BT (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol 103, 26-35.
    • (2002) Acta Neuropathol , vol.103 , pp. 26-35
    • Augustinack, J.C.1    Schneider, A.2    Mandelkow, E.-M.3    Hyman, B.T.4
  • 88
    • 33750510335 scopus 로고    scopus 로고
    • PKA modulates GSK-3betaand cdk5-catalyzed phosphorylation of tau in site-and kinase-specific manners
    • Liu F, Liang Z, Shi J, Yin D, El-Akkad E, Grundke-Iqbal I, Iqbal K, Gong C-X (2006) PKA modulates GSK-3betaand cdk5-catalyzed phosphorylation of tau in site-and kinase-specific manners. FEBS Lett 580, 6269-6274.
    • (2006) FEBS Lett , vol.580 , pp. 6269-6274
    • Liu, F.1    Liang, Z.2    Shi, J.3    Yin, D.4    El-Akkad, E.5    Grundke-Iqbal, I.6    Iqbal, K.7    Gong, C.-X.8
  • 90
    • 14044270858 scopus 로고    scopus 로고
    • Evidence that phosphorylation of the microtubuleassociated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly
    • Feijoo C, Campbell DG, Jakes R, Goedert M, Cuenda A (2005) Evidence that phosphorylation of the microtubuleassociated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly. J Cell Sci 118, 397-408.
    • (2005) J Cell Sci , vol.118 , pp. 397-408
    • Feijoo, C.1    Campbell, D.G.2    Jakes, R.3    Goedert, M.4    Cuenda, A.5
  • 91
    • 84924163148 scopus 로고    scopus 로고
    • A novel, ultrasensitive assay for tau: Potential for assessing traumatic brain injury in tissues and biofluids
    • Rubenstein R, Chang B, Davies P, Wagner AK, Robertson CS, Wang KKW (2015) A novel, ultrasensitive assay for tau: Potential for assessing traumatic brain injury in tissues and biofluids. J Neurotrauma 32, 342-352.
    • (2015) J Neurotrauma , vol.32 , pp. 342-352
    • Rubenstein, R.1    Chang, B.2    Davies, P.3    Wagner, A.K.4    Robertson, C.S.5    Wang, K.K.W.6
  • 92
    • 85042407518 scopus 로고    scopus 로고
    • Relevance of phosphorylation and truncation of tau to the etiopathogenesis of Alzheimer's disease
    • Zhou Y, Shi J, Chu D, HuW, Guan Z, Gong C-X, Iqbal K, Liu F (2018) Relevance of phosphorylation and truncation of tau to the etiopathogenesis of Alzheimer's disease.Front Aging Neurosci 10, 27.
    • (2018) Front Aging Neurosci , vol.10 , pp. 27
    • Zhou, Y.1    Shi, J.2    Chu, D.3    Hu, W.4    Guan, Z.5    Gong, C.-X.6    Iqbal, K.7    Liu, F.8
  • 93
    • 84922576117 scopus 로고    scopus 로고
    • Pseudophosphorylation of tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein tau to dendritic spines
    • Xia D, Li C, Gotz J (2015) Pseudophosphorylation of tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein tau to dendritic spines. Biochim Biophys Acta 1852, 913-924.
    • (2015) Biochim Biophys Acta , vol.1852 , pp. 913-924
    • Xia, D.1    Li, C.2    Gotz, J.3
  • 101
    • 27644478606 scopus 로고    scopus 로고
    • Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    • Liu F, Grundke-Iqbal I, Iqbal K, Gong C-X (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22, 1942-1950.
    • (2005) Eur J Neurosci , vol.22 , pp. 1942-1950
    • Liu, F.1    Grundke-Iqbal, I.2    Iqbal, K.3    Gong, C.-X.4
  • 102
    • 84878760670 scopus 로고    scopus 로고
    • Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development
    • Geerts H, Spiros A, Roberts P, Carr R (2013) Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development. J Pharmacokinet Pharmacodyn 40, 257-265.
    • (2013) J Pharmacokinet Pharmacodyn , vol.40 , pp. 257-265
    • Geerts, H.1    Spiros, A.2    Roberts, P.3    Carr, R.4
  • 103
    • 85041613843 scopus 로고    scopus 로고
    • Impact of amyloidbeta changes on cognitive outcomes in Alzheimer's disease: Analysis of clinical trials using a quantitative systems pharmacology model
    • Geerts H, Spiros A, Roberts P (2018) Impact of amyloidbeta changes on cognitive outcomes in Alzheimer's disease: Analysis of clinical trials using a quantitative systems pharmacology model. Alzheimers Res Ther 10, 14.
    • (2018) Alzheimers Res Ther , vol.10 , pp. 14
    • Geerts, H.1    Spiros, A.2    Roberts, P.3


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