Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3β

Chemico-Biological Interactions

Volumn 203, Issue 1, 2013, Pages 309-313

  Jing, Peng ^a   Zhang, Jing Ya ^a   Ouyang, Qi ^a   Wu, Jun ^a   Zhang, Xue Jun ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Acetylcholinesterase (AChE); Glycogen synthase kinase 3 (GSK3 ); HEK293T cells; Proteasome

Indexed keywords

ACETYLCHOLINESTERASE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; PROTEOME;

ANIMAL CELL; CELL STRAIN HEK293; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME STABILITY; GENETIC TRANSFECTION; IMMUNOBLOTTING; NONHUMAN; PC12 CELL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMALS; ENZYME INHIBITORS; ENZYME STABILITY; GLYCOGEN SYNTHASE KINASE 3; GPI-LINKED PROTEINS; HEK293 CELLS; HUMANS; LEUPEPTINS; LITHIUM; MUTAGENESIS, SITE-DIRECTED; PC12 CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RECOMBINANT PROTEINS;

EID: 84875803609     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.010     Document Type: Conference Paper

References (31)

1. P. Davies, and A.J. Maloney Selective loss of central cholinergic neurons in Alzheimer's disease Lancet 2 8000 1976 1403
2. J. Ulrich Senile plaques: staining for acetylcholinesterase and A4 protein: a comparative study in the hippocampus and entorhinal cortex Acta Neuropathol. (Berl) 80 6 1990 624 628
3. P. Taylor, and Z. Radic The cholinesterases: from genes to proteins Annu. Rev. Pharmacol. Toxicol. 34 1994 281 320
4. D. Toiber N-acetylcholinesterase-induced apoptosis in Alzheimer's disease PLoS One 3 9 2008 e3108
5. X.J. Zhang, and D. Greenberg Acetylcholinesterase involvement in apoptosis Front. Mol. Neurosci. 2012 http://dx.doi.org/ 10.3389/fnmol.2012.00040
6. X.J. Zhang Induction of acetylcholinesterase expression during apoptosis in various cell types Cell Death Differ. 9 8 2002 790 800
7. J. Xie Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway J. Mol. Cell Biol. 3 4 2011 250 259
8. W.Y. Ye AChE deficiency or inhibition decreases apoptosis and p53 expression and protects renal function after ischemia/reperfusion Apoptosis 15 4 2010 474 487
9. B. Zhang Acetylcholinesterase is associated with apoptosis in cells and contributes to insulin-dependent diabetes mellitus pathogenesis Acta Biochimica Et Biophysica Sinica. 44 3 2012 207 216
10. R.H. Belmaker Bipolar disorder N. Engl. J. Med. 351 5 2004 476 486
11. R.S. Jope, and G.V. Johnson The glamour and gloom of glycogen synthase kinase-3 Trends Biochem. Sci. 29 2 2004 95 102
12. J. Zhong, and W.H. Lee Lithium: a novel treatment for Alzheimer's disease? Expert. Opin. Drug Saf. 6 4 2007 375 383
13. P. Jing GSK3beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis J. Neurochem. 104 2 2008 409 419
14. G.L. Ellman A new and rapid colorimetric determination of acetylcholinesterase activity Biochem. Pharmacol. 7 1961 88 95
15. B.W. Doble, and J.R. Woodgett GSK-3: tricks of the trade for a multi-tasking kinase J. Cell Sci. 116 Pt 7 2003 1175 1186
16. P.S. Klein, and D.A. Melton A molecular mechanism for the effect of lithium on development Proc. Natl. Acad. Sci. USA 93 16 1996 8455 8459
17. H. Zhu Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis Int. J. Biochem. Cell Biol. 39 1 2007 93 108
18. P. Jing GSK3beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis J. Neurochem. 2007
19. C.A. Ross Polyglutamine fibrillogenesis: the pathway unfolds Proc. Natl. Acad. Sci. USA 100 1 2003 1 3
20. T. Chitlaru Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels Biochem. J. 336 Pt 3 1998 647 658
21. C. Kronman Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation Biochem. J. 311 Pt 3 1995 959 967
22. A. Saxena Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase Biochemistry 36 24 1997 7481 7489
23. H. Soreq Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure Proc. Natl. Acad. Sci. USA 87 24 1990 9688 9692
24. R.L. Rotundo Biogenesis of acetylcholinesterase molecular forms in muscle. Evidence for a rapidly turning over, catalytically inactive precursor pool J. Biol. Chem. 263 36 1988 19398 19406
25. B. Velan The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580 - Ala mutant J. Biol. Chem. 266 35 1991 23977 23984
26. R.L. Rotundo, and D.M. Fambrough Synthesis, transport and fate of acetylcholinesterase in cultured chick embryos muscle cells Cell 22 2 Pt 2 1980 583 594
27. B. Velan N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis Biochem. J. 296 Pt 3 1993 649 656
28. S.I. Han MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3 Mol. Cell. Biol. 27 19 2007 6593 6605
29. L. Yin Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock Science 311 5763 2006 1002 1005
30. S. Taurin Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase J. Biol. Chem. 281 15 2006 9971 9976
31. M. Grifman In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis Brain Res. Mol. Brain Res. 51 1-2 1997 179 187