GSK3β overexpression driven by GFAP promoter improves rotarod performance

Brain Research

Volumn 1712, Issue , 2019, Pages 47-54

  Jurado Arjona, Jerónimo ^a,b   Rodríguez Matellán, Alberto ^a,b   Ávila, Jesús ^a,b   Hernández, Félix ^a,b  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

Author keywords

Bergmann cells; GSK3 ; Rotarod test; Transgenic

Indexed keywords

BETA GALACTOSIDASE; DOXYCYCLINE; EXCITATORY AMINO ACID TRANSPORTER; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR SOX2; VESICULAR GLUTAMATE TRANSPORTER 1; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; GLUTAMATE TRANSPORTER; GSK3B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BERGMANN GLIA CELL; CEREBELLUM DISEASE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENE OVEREXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LATENCY TO FALL; MOTOR COORDINATION; MOTOR PERFORMANCE; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; ROTAROD TEST; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; ASTROCYTE; BIOSYNTHESIS; BRAIN; C57BL MOUSE; CEREBELLUM; GENETICS; GLIA; KNOCKOUT MOUSE; MALE; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; PROCEDURES;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ASTROCYTES; BRAIN; CEREBELLUM; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOGEN SYNTHASE KINASE 3 BETA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOTOR ACTIVITY; NEURAL STEM CELLS; NEUROGLIA; PROMOTER REGIONS, GENETIC; ROTAROD PERFORMANCE TEST; TRANS-ACTIVATORS;

EID: 85061007173     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2019.01.040     Document Type: Article

References (38)

1. Ahlfeld, J., et al. Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex. Sci. Rep., 7, 2017, 6137.
2. Altman, J., Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J. Comp. Neurol. 145 (1972), 399–463.
3. Bergles, D.E., Dzubay, J.A., Jahr, C.E., Glutamate transporter currents in bergmann glial cells follow the time course of extrasynaptic glutamate. Proc. Natl. Acad. Sci. U.S.A. 94 (1997), 14821–14825.
4. Besnard, F., et al. Multiple interacting sites regulate astrocyte-specific transcription of the human gene for glial fibrillary acidic protein. J. Biol. Chem. 266 (1991), 18877–18883.
5. Beurel, E., Grieco, S.F., Jope, R.S., Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol. Ther. 148 (2015), 114–131.
6. Brenner, M., et al. GFAP promoter directs astrocyte-specific expression in transgenic mice. J. Neurosci. 14 (1994), 1030–1037.
7. Chaudhry, F.A., et al. Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron 15 (1995), 711–720.
8. De Zeeuw, C.I., Hoogland, T.M., Reappraisal of Bergmann glial cells as modulators of cerebellar circuit function. Front. Cell. Neurosci., 9, 2015, 246.
9. Fuster-Matanzo, A., et al. Dual effects of increased glycogen synthase kinase-3beta activity on adult neurogenesis. Hum. Mol. Genet. 22 (2013), 1300–1315.
10. Fuster-Matanzo, A., et al. Glycogen synthase kinase-3beta regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer's disease. Cell. Mol. Life Sci. 74 (2017), 1153–1163.
11. Goldowitz, D., Hamre, K., The cells and molecules that make a cerebellum. Trends Neurosci. 21 (1998), 375–382.
12. Gomez-Sintes, R., Lucas, J.J., NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy. J. Clin. Invest. 120 (2010), 2432–2445.
13. Haugeto, O., et al. Brain glutamate transporter proteins form homomultimers. J. Biol. Chem. 271 (1996), 27715–27722.
14. Jia, D.D., et al. Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3beta in a SCA3 Drosophila model. Cerebellum 12 (2013), 892–901.
15. Jimenez, E., et al. Differential regulation of the glutamate transporters GLT-1 and GLAST by GSK3beta. Neurochem. Int. 79 (2014), 33–43.
16. Jurado-Arjona, J., et al. GSK3beta overexpression in dentate gyrus neural precursor cells expands the progenitor pool and enhances memory skills. J. Biol. Chem. 291 (2016), 8199–8213.
17. Kern, J.K., The possible role of the cerebellum in autism/PDD: disruption of a multisensory feedback loop. Med. Hypotheses 59 (2002), 255–260.
18. Kim, W.Y., et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nat. Neurosci. 12 (2009), 1390–1397.
19. Klein, C., et al. Cerebellum- and forebrain-derived stem cells possess intrinsic regional character. Development 132 (2005), 4497–4508.
20. Klein, P.S., Melton, D.A., A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. U.S.A. 93 (1996), 8455–8459.
21. Lee, A., et al. Isolation of neural stem cells from the postnatal cerebellum. Nat. Neurosci. 8 (2005), 723–729.
22. Lin, W., et al. Interferon-gamma induced medulloblastoma in the developing cerebellum. J. Neurosci. 24 (2004), 10074–10083.
23. Lucas, J.J., et al. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 20 (2001), 27–39.
24. Llorens-Martin, M., Torres-Aleman, I., Trejo, J.L., Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons. Hippocampus 16 (2006), 480–490.
25. Llorens-Martin, M., et al. GSK-3beta overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo. Mol. Psychiatry 18 (2013), 451–460.
26. Marras, C., et al. Lithium use in older adults is associated with increased prescribing of parkinson medications. Am J Geriatr Psychiatry 24 (2016), 301–309.
27. Martin, P., Albers, M., Cerebellum and schizophrenia: a selective review. Schizophr. Bull. 21 (1995), 241–250.
28. Miyazaki, T., et al. Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells. Proc. Natl. Acad. Sci. U.S.A., 2017.
29. Niethammer, M., Ford, B., Permanent lithium-induced cerebellar toxicity: three cases and review of literature. Mov. Disord. 22 (2007), 570–573.
30. Pastori, V., et al. CK2 and GSK3 phosphorylation on S29 controls wild-type ATXN3 nuclear uptake. BBA 1802 (2010), 583–592.
31. Rapoport, M., van Reekum, R., Mayberg, H., The role of the cerebellum in cognition and behavior: a selective review. J. Neuropsychiatry Clin. Neurosci. 12 (2000), 193–198.
32. Rosenberg, R.N., Grossman, A., Hereditary ataxia. Neurol. Clin. 7 (1989), 25–36.
33. Shiotsuki, H., et al. A rotarod test for evaluation of motor skill learning. J. Neurosci. Methods 189 (2010), 180–185.
34. Sottile, V., Li, M., Scotting, P.J., Stem cell marker expression in the Bergmann glia population of the adult mouse brain. Brain Res. 1099 (2006), 8–17.
35. ten Donkelaar, H.J., et al. Development and developmental disorders of the human cerebellum. J. Neurol. 250 (2003), 1025–1036.
36. Voogd, J., Glickstein, M., The anatomy of the cerebellum. Trends Cogn. Sci. 2 (1998), 307–313.
37. Watase, K., et al. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model. PLoS Med., 4, 2007, e182.
38. Weber, T., et al. Inducible gene expression in GFAP+ progenitor cells of the SGZ and the dorsal wall of the SVZ-A novel tool to manipulate and trace adult neurogenesis. Glia 59 (2011), 615–626.