Chronic microdose lithium treatment prevented memory loss and neurohistopathological changes in a transgenic mouse model of Alzheimer's disease

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Nunes, Marielza Andrade ^a,c   Schöwe, Natalia Mendes ^b,c   Monteiro Silva, Karla Cristina ^a   Baraldi Tornisielo, Ticiana ^a,c   Souza, Suzzanna Ingryd Gonçalves ^a   Balthazar, Janaina ^b   Albuquerque, Marilia Silva ^a,c   Caetano, Ariadiny Lima ^a,c   Viel, Tania Araujo ^b,c   Buck, Hudson Sousa ^a,c  

^a Medical School of Santa Casa of Sao Paulo SP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Research Group on Neuropharmacology of Aging   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOGEN SYNTHASE KINASE 3; LITHIUM CARBONATE; NEURON SPECIFIC NUCLEAR PROTEIN; NEUROPROTECTIVE AGENT;

AGE DISTRIBUTION; ALZHEIMER DISEASE; AMNESIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; AVERSION; BRAIN PROTECTION; CELL DENSITY; CELL LOSS; CONTROLLED STUDY; DENTATE GYRUS GRANULAR LAYER; DISEASE COURSE; DRUG EFFICACY; DRUG MICRODOSE; ELEVATED PLUS MAZE TEST; ENZYME ACTIVITY; ENZYME INHIBITION; HIPPOCAMPUS; HISTOPATHOLOGY; LATENT PERIOD; LOCOMOTION; LONG TERM CARE; LOW DRUG DOSE; MALE; MORTALITY; MOUSE; NEPHROTOXICITY; NERVE CELL; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; PREFRONTAL CORTEX; PROPHYLAXIS; PROTEIN LOCALIZATION; SENILE PLAQUE; SPATIAL MEMORY; TASK PERFORMANCE; TISSUE DISTRIBUTION; TRANQUILIZING ACTIVITY; TRANSGENIC MOUSE; TREATMENT DURATION; ANIMAL; AVOIDANCE BEHAVIOR; BRAIN CORTEX; COGNITION DISORDERS; DISEASE MODEL; DRUG ADMINISTRATION; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HUMAN; MAZE TEST; MEMORY; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PLAQUE, AMYLOID;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; AMNESIA; ANIMALS; AVOIDANCE LEARNING; BRAIN-DERIVED NEUROTROPHIC FACTOR; CEREBRAL CORTEX; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; LITHIUM CARBONATE; LOCOMOTION; MALE; MAZE LEARNING; MEMORY; MICE; MICE, TRANSGENIC; NEUROPROTECTIVE AGENTS; PLAQUE, AMYLOID;

EID: 84956961424     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0142267     Document Type: Article

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