-
2
-
-
84963972074
-
2016 Alzheimer's disease facts and figures
-
Alzheimer's Association
-
Alzheimer's Association (2016) 2016 Alzheimer's disease facts and figures. Alzheimers Dement 12, 459-509.
-
(2016)
Alzheimers Dement
, vol.12
, pp. 459-509
-
-
-
3
-
-
85061810561
-
-
Alzheimer's Disease International,World Alzheimer Report, Accessed on March 17, 2017
-
Alzheimer's Disease International,World Alzheimer Report 2016: The global impact of dementia, Alzheimer's Disease International, https://www.alz.co.uk/research/World AlzheimerReport2016.pdf, Accessed on March 17, 2017.
-
(2016)
The Global Impact of Dementia, Alzheimer's Disease International
-
-
-
5
-
-
84919665907
-
Dominantly Inherited Alzheimer Network 2014 Genetic heterogeneity in Alzheimer disease and implications for treatment strategies
-
Ringman JM, Goate A, Masters CL, Cairns NJ, Danek A, Graff-Radford N, Ghetti B, Morris JC, Dominantly Inherited Alzheimer Network (2014) Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Curr Neurol Neurosci Rep 14, 499.
-
Curr Neurol Neurosci Rep
, vol.14
, pp. 499
-
-
Ringman, J.M.1
Goate, A.2
Masters, C.L.3
Cairns, N.J.4
Danek, A.5
Graff-Radford, N.6
Ghetti, B.7
Morris, J.C.8
-
6
-
-
84963520567
-
The amyloid hypothesis of Alzheimer's disease at 25 years
-
Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med 8, 595-608.
-
(2016)
EMBO Mol Med
, vol.8
, pp. 595-608
-
-
Selkoe, D.J.1
Hardy, J.2
-
7
-
-
19944375450
-
Tau pathology in Alzheimer disease and other tauopathies
-
Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I (2005) Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta 1739, 198-210.
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 198-210
-
-
Iqbal, K.1
Alonso Adel, C.2
Chen, S.3
Chohan, M.O.4
El-Akkad, E.5
Gong, C.X.6
Khatoon, S.7
Li, B.8
Liu, F.9
Rahman, A.10
Tanimukai, H.11
Grundke-Iqbal, I.12
-
8
-
-
55849111494
-
Cholinergic system during the progression of Alzheimer's disease: Therapeutic implications
-
Mufson EJ, Counts SE, Perez SE, Ginsberg SD (2008) Cholinergic system during the progression of Alzheimer's disease: Therapeutic implications. Expert Rev Neurother 8, 1703-1718.
-
(2008)
Expert Rev Neurother
, vol.8
, pp. 1703-1718
-
-
Mufson, E.J.1
Counts, S.E.2
Perez, S.E.3
Ginsberg, S.D.4
-
9
-
-
84894090892
-
Targeting the beta secretase BACE1 for Alzheimer's disease therapy
-
Yan R, Vassar R (2014) Targeting the beta secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol 13, 319-329.
-
(2014)
Lancet Neurol
, vol.13
, pp. 319-329
-
-
Yan, R.1
Vassar, R.2
-
10
-
-
84903947419
-
Alzheimer's disease drug-development pipeline: Few candidates, frequent failures
-
Cummings JL, MorstorfT, ZhongK(2014) Alzheimer's disease drug-development pipeline: Few candidates, frequent failures. Alzheimers Res Ther 6, 37.
-
(2014)
Alzheimers Res Ther
, vol.6
, pp. 37
-
-
Cummings, J.L.1
Morstorf, T.2
Zhong, K.3
-
11
-
-
34547464547
-
-
Aricept 2015 donepezil hydrochloride, Eisai Inc., Woodcliff Lake, NJ
-
Aricept (2015) (donepezil hydrochloride). Full Prescribing Information, Eisai Inc., Woodcliff Lake, NJ.
-
Full Prescribing Information
-
-
-
12
-
-
34547464547
-
-
Exelon, rivastigmine tartrate, Novartis Pharmaceuticals Corporation, East Hanover, NJ
-
Exelon (2015) (rivastigmine tartrate). Full Prescribing Information, Novartis Pharmaceuticals Corporation, East Hanover, NJ.
-
(2015)
Full Prescribing Information
-
-
-
15
-
-
85061808796
-
Memantine hydrochloride Full Prescribing Information, Forest Pharmaceuticals Inc
-
St Louis, MO
-
Namenda XR (2014) (memantine hydrochloride). Full Prescribing Information, Forest Pharmaceuticals Inc., St. Louis, MO.
-
(2014)
-
-
Namenda, X.R.1
-
16
-
-
85061827615
-
Memantine and donepezil hydrochlorides
-
Namzaric, Allergan USA, Inc., Irvine, CA
-
Namzaric (2016) (memantine and donepezil hydrochlorides). Full Prescribing Information, Allergan USA, Inc., Irvine, CA.
-
(2016)
Full Prescribing Information
-
-
-
17
-
-
84861547140
-
AlzPathway: A comprehensive map of signaling pathways of Alzheimer's disease
-
Mizuno S, Iijima R, Ogishima S, Kikuchi M, Matsuoka Y, Ghosh S, Miyamoto T, Miyashita A, Kuwano R, Tanaka H (2012) AlzPathway: A comprehensive map of signaling pathways of Alzheimer's disease. BMC Syst Biol 6, 52.
-
(2012)
BMC Syst Biol
, vol.6
, pp. 52
-
-
Mizuno, S.1
Iijima, R.2
Ogishima, S.3
Kikuchi, M.4
Matsuoka, Y.5
Ghosh, S.6
Miyamoto, T.7
Miyashita, A.8
Kuwano, R.9
Tanaka, H.10
-
18
-
-
10044270820
-
Combination therapy in Alzheimer's disease: A review of current evidence
-
Schmitt B, Bernhardt T, Moeller HJ, Heuser I, Frolich L (2004) Combination therapy in Alzheimer's disease: A review of current evidence. CNS Drugs 18, 827-844.
-
(2004)
CNS Drugs
, vol.18
, pp. 827-844
-
-
Schmitt, B.1
Bernhardt, T.2
Moeller, H.J.3
Heuser, I.4
Frolich, L.5
-
19
-
-
85018753716
-
Concordance of several subcellular interactions initiates Alzheimer's dementia: Their reversal requires combination treatment
-
Fessel WJ (2017) Concordance of several subcellular interactions initiates Alzheimer's dementia: Their reversal requires combination treatment. Am J Alzheimers Dis Other Demen 32, 166-181.
-
(2017)
Am J Alzheimers Dis Other Demen
, vol.32
, pp. 166-181
-
-
Fessel, W.J.1
-
20
-
-
85004101333
-
Combination therapy of anti-Tau and anti-Amyloid drugs for disease modification in early-stage Alzheimer's disease: Socio-economic considerations modeled on treatments for tuberculosis, HIV/AIDS and breast cancer
-
Tomaszewski S, Gauthier S, Wimo A, Rosa-Neto P (2016) Combination therapy of anti-Tau and anti-Amyloid drugs for disease modification in early-stage Alzheimer's disease: Socio-economic considerations modeled on treatments for tuberculosis, HIV/AIDS and breast cancer. J Prev Alzheimers Dis 3, 164-172.
-
(2016)
J Prev Alzheimers Dis
, vol.3
, pp. 164-172
-
-
Tomaszewski, S.1
Gauthier, S.2
Wimo, A.3
Rosa-Neto, P.4
-
21
-
-
27644582473
-
Pharmacologic principles for combination therapy
-
Toews ML, Bylund DB (2005) Pharmacologic principles for combination therapy. Proc Am Thorac Soc 2, 282-289.
-
(2005)
Proc Am Thorac Soc
, vol.2
, pp. 282-289
-
-
Toews, M.L.1
Bylund, D.B.2
-
22
-
-
0015501193
-
Levodopa combined with peripheral decarboxylase inhibition in Parkinson?s disease
-
Barbeau A, Mars H, Botez MI, Joubert M (1972) Levodopa combined with peripheral decarboxylase inhibition in Parkinson?s disease. Can Med Assoc J 106, 1169-1174.
-
(1972)
Can Med Assoc J
, vol.106
, pp. 1169-1174
-
-
Barbeau, A.1
Mars, H.2
Botez, M.I.3
Joubert, M.4
-
23
-
-
78249270418
-
Safety Tolerability and Efficacy Results Trial of AVP-923 in PBA Investigators 2010 Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect
-
Pioro EP, Brooks BR, Cummings. J Schiffer R Thisted RA Wynn D Hepner A Kaye R Safety, Tolerability and Efficacy Results Trial of AVP-923 in PBA Investigators (2010) Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Ann Neurol 68, 693-702.
-
Ann Neurol
, vol.68
, pp. 693-702
-
-
Pioro, E.P.1
Brooks, B.R.2
Cummings, J.3
Schiffer, R.4
Thisted, R.A.5
Wynn, D.6
Hepner, A.7
Kaye, R.8
-
24
-
-
85029884633
-
Defining disease modifying therapy for Alzheimer's disease
-
Cummings. J, Fox N (2017) Defining disease modifying therapy for Alzheimer's disease. J Prev Alzheimers Dis 4, 109-115.
-
(2017)
J Prev Alzheimers Dis
, vol.4
, pp. 109-115
-
-
Cummings, J.1
Fox, N.2
-
25
-
-
79952775194
-
Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy
-
Wang A, Das P, Switzer RC, 3rd, Golde TE, Jankowsky JL (2011) Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy. J Neurosci 31, 4124-4136.
-
(2011)
J Neurosci
, vol.31
, pp. 4124-4136
-
-
Wang, A.1
Das, P.2
Switzer, R.C.3
Golde, T.E.4
Jankowsky, J.L.5
-
26
-
-
81755177047
-
Alzheimer's Disease Neuroimaging Initiative 2011 Evidence for ordering of Alzheimer disease biomarkers
-
Jack CR, Jr., Vemuri P, Wiste HJ, Weigand SD, Aisen PS, Trojanowski JQ, Shaw LM, Bernstein MA, Petersen RC, Weiner MW, Knopman DS, Alzheimer's Disease Neuroimaging, Initiative (2011) Evidence for ordering of Alzheimer disease biomarkers. Arch Neurol 68, 1526-1535.
-
Arch Neurol
, vol.68
, pp. 1526-1535
-
-
Jack, C.R.1
Vemuri, P.2
Wiste, H.J.3
Weigand, S.D.4
Aisen, P.S.5
Trojanowski, J.Q.6
Shaw, L.M.7
Bernstein, M.A.8
Petersen, R.C.9
Weiner, M.W.10
Knopman, D.S.11
-
27
-
-
2342655732
-
A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease
-
Parkinson Study Group
-
Parkinson Study Group (2004) A controlled, randomized, delayed-start study of rasagiline in early Parkinson disease. Arch Neurol 61, 561-566.
-
(2004)
Arch Neurol
, vol.61
, pp. 561-566
-
-
-
28
-
-
0035568344
-
Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]
-
Youdim MB, Weinstock M (2001) Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol 21, 555-573.
-
(2001)
Cell Mol Neurobiol
, vol.21
, pp. 555-573
-
-
Youdim, M.B.1
Weinstock, M.2
-
30
-
-
84994492966
-
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS beta-Amyloid in animal models and in Alzheimer's disease patients
-
Kennedy ME, Stamford AW, Chen X, Cox K, Cumming JN, DockendorfMF, EganM, Ereshefsky L, Hodgson RA, Hyde LA, Jhee S, Kleijn HJ, Kuvelkar R, LiW, Mattson BA,Mei H, Palcza. J, Scott JD,Tanen M,TroyerMD,Tseng JL, Stone JA, Parker EM, Forman MS (2016) The BACE1 inhibitor verubecestat (MK-8931) reduces CNS beta-Amyloid in animal models and in Alzheimer's disease patients. Sci Transl Med 8, 363ra450.
-
(2016)
Sci Transl Med
, vol.8
, pp. 363-450
-
-
Kennedy, M.E.1
Stamford, A.W.2
Chen, X.3
Cox, K.4
Cumming, J.N.5
Dockendorf, M.F.6
Egan, M.7
Ereshefsky, L.8
Hodgson, R.A.9
Hyde, L.A.10
Jhee, S.11
Kleijn, H.J.12
Kuvelkar, R.13
LiW Mattson Bamei, H.14
Palcza, J.15
Scott, J.D.16
Tanen, M.17
Troyer, M.D.18
Tseng, J.L.19
Stone, J.A.20
Parker, E.M.21
Forman, M.S.22
more..
-
31
-
-
85046674511
-
Randomized trial of verubecestat for mild-To-moderate Alzheimer's disease
-
EganMF,Kost. J,Tariot PN, Aisen PS, Cummings JL,Vellas B, Sur C, Mukai Y, Voss T, Furtek C, Mahoney E, Harper Mozley L, Vandenberghe R, Mo Y, Michelson D (2018) Randomized trial of verubecestat for mild-To-moderate Alzheimer's disease. N Engl J Med 378, 1691-1703.
-
(2018)
N Engl J Med
, vol.378
, pp. 1691-1703
-
-
Egan, M.F.1
Kost, J.2
Tariot, P.N.3
Aisen, P.S.4
Cummings Jlvellas, B.5
Sur, C.6
Mukai, Y.7
Voss, T.8
Furtek, C.9
Mahoney, E.10
Harper Mozley, L.11
Vandenberghe, R.12
Mo, Y.13
Michelson, D.14
-
34
-
-
84985896386
-
The antibody aducanumab reduces Abeta plaques in Alzheimer's disease
-
Sevigny. J, Chiao P, Bussiere T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O?Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A (2016) The antibody aducanumab reduces Abeta plaques in Alzheimer's disease. Nature 537, 50-56.
-
(2016)
Nature
, vol.537
, pp. 50-56
-
-
Sevigny, J.1
Chiao, P.2
Bussiere, T.3
Weinreb, P.H.4
Williams, L.5
Maier, M.6
Dunstan, R.7
Salloway, S.8
Chen, T.9
Ling, Y.10
Ogorman, J.11
Qian, F.12
Arastu, M.13
Li, M.14
Chollate, S.15
Brennan, M.S.16
Quintero-Monzon, O.17
Scannevin, R.H.18
Arnold, H.M.19
Engber, T.20
Rhodes, K.21
Ferrero, J.22
Hang, Y.23
Mikulskis, A.24
Grimm, J.25
Hock, C.26
Nitsch, R.M.27
Sandrock, A.28
more..
-
35
-
-
84887763795
-
Profile of gantenerumab and its potential in the treatment of Alzheimer's disease
-
Novakovic D, Feligioni M, Scaccianoce S, Caruso A, Piccinin S, Schepisi C, Errico F, Mercuri NB, Nicoletti F, Nistico R (2013) Profile of gantenerumab and its potential in the treatment of Alzheimer's disease. Drug Des Devel Ther 7, 1359-1364.
-
(2013)
Drug des Devel Ther
, vol.7
, pp. 1359-1364
-
-
Novakovic, D.1
Feligioni, M.2
Scaccianoce, S.3
Caruso, A.4
Piccinin, S.5
Schepisi, C.6
Errico, F.7
Mercuri, N.B.8
Nicoletti, F.9
Nistico, R.10
-
36
-
-
85060790867
-
Exploratory analyses of cognitive effects of crenezumab in a mild Alzheimer's disease subpopulation of a randomized, double-blind, placebo controlled, parallelgroup phase 2 study (ABBY
-
Mackey H, Cho W, Ward M, Fang Y, Suliman S, Ho C, Paul R (2016) Exploratory analyses of cognitive effects of crenezumab in a mild Alzheimer's disease subpopulation of a randomized, double-blind, placebo controlled, parallelgroup phase 2 study (ABBY). Alzheimers Dement 12, P610.
-
(2016)
Alzheimers Dement
, vol.12
, pp. P610
-
-
Mackey, H.1
Cho, W.2
Ward, M.3
Fang, Y.4
Suliman, S.5
Ho, C.6
Paul, R.7
-
37
-
-
84892695519
-
Two phase 3 trials of bapineuzumab in mild-To-moderate Alzheimer's disease
-
Bapineuzumab clinical trial investigators
-
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR, Bapineuzumab Clinical Trial Investigators (2014) Two phase 3 trials of bapineuzumab in mild-To-moderate Alzheimer's disease. N Engl J Med 370, 322-333.
-
(2014)
N Engl J Med
, vol.370
, pp. 322-333
-
-
Salloway, S.1
Sperling, R.2
Fox, N.C.3
Blennow, K.4
Klunk, W.5
Raskind, M.6
Sabbagh, M.7
Honig, L.S.8
Porsteinsson, A.P.9
Ferris, S.10
Reichert, M.11
Ketter, N.12
Nejadnik, B.13
Guenzler, V.14
Miloslavsky, M.15
Wang, D.16
Lu, Y.17
Lull, J.18
Tudor, I.C.19
Liu, E.20
Grundman, M.21
Yuen, E.22
Black, R.23
Brashear, H.R.24
more..
-
39
-
-
84892748542
-
Alzheimer's disease cooperative study steering committee solanezumab study group 2014 phase 3 trials of solanezumab for mild-To-moderate Alzheimer?s disease
-
Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R, Alzheimer's Disease Cooperative Study Steering Committee, Solanezumab Study, Group (2014) Phase 3 trials of solanezumab for mild-To-moderate Alzheimer's disease. N Engl J Med 370, 311-321.
-
N Engl J Med
, vol.370
, pp. 311-321
-
-
Doody, R.S.1
Thomas, R.G.2
Farlow, M.3
Iwatsubo, T.4
Vellas, B.5
Joffe, S.6
Kieburtz, K.7
Raman, R.8
Sun, X.9
Aisen, P.S.10
Siemers, E.11
Liu-Seifert, H.12
Mohs, R.13
-
40
-
-
85002578779
-
Dian-Tu Pharma Consortium for the Dominantly Inherited Alzheimer Network (2017) the DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model
-
Bateman RJ, Benzinger TL, Berry S, Clifford DB, Duggan C, Fagan AM, Fanning K, Farlow MR, Hassenstab J, McDade EM, Mills S, Paumier K, Quintana M, Salloway SP, Santacruz A, Schneider LS, Wang G, Xiong C, Dian-Tu Pharma Consortium for the Dominantly Inherited Alzheimer Network (2017) The DIAN-TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model. Alzheimers Dement 13, 8-19.
-
Alzheimers Dement
, vol.13
, pp. 8-19
-
-
Bateman, R.J.1
Benzinger, T.L.2
Berry, S.3
Clifford, D.B.4
Duggan, C.5
Fagan, A.M.6
Fanning, K.7
Farlow, M.R.8
Hassenstab, J.9
McDade, E.M.10
Mills, S.11
Paumier, K.12
Quintana, M.13
Salloway, S.P.14
Santacruz, A.15
Schneider, L.S.16
Wang, G.17
Xiong, C.18
-
43
-
-
84982860160
-
Tau-centric targets and drugs in clinical development for the treatment of Alzheimer's disease
-
Panza F, Solfrizzi V, Seripa D, Imbimbo BP, Lozupone M, Santamato A, Zecca C, Barulli MR, Bellomo A, Pilotto A, Daniele A, Greco A, Logroscino G (2016) Tau-centric targets and drugs in clinical development for the treatment of Alzheimer's disease. Biomed Res Int 2016, 3245935.
-
(2016)
Biomed Res Int
, vol.2016
, pp. 3245935
-
-
Panza, F.1
Solfrizzi, V.2
Seripa, D.3
Imbimbo, B.P.4
Lozupone, M.5
Santamato, A.6
Zecca, C.7
Barulli, M.R.8
Bellomo, A.9
Pilotto, A.10
Daniele, A.11
Greco, A.12
Logroscino, G.13
-
44
-
-
85003441308
-
Efficacy and safety of tau-Aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: A randomised, controlled, double-blind, parallel-Arm, phase 3 trial
-
Gauthier S, Feldman HH, Schneider LS, Wilcock GK, Frisoni GB, Hardlund JH, Moebius HJ, Bentham P, Kook KA, Wischik DJ, Schelter BO, Davis CS, Staff RT, Bracoud L, Shamsi K, Storey JM, Harrington CR,Wischik CM (2016) Efficacy and safety of tau-Aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: A randomised, controlled, double-blind, parallel-Arm, phase 3 trial. Lancet 388, 2873-2884.
-
(2016)
Lancet
, vol.388
, pp. 2873-2884
-
-
Gauthier, S.1
Feldman, H.H.2
Schneider, L.S.3
Wilcock, G.K.4
Frisoni, G.B.5
Hardlund, J.H.6
Moebius, H.J.7
Bentham, P.8
Kook, K.A.9
Wischik, D.J.10
Schelter, B.O.11
Davis, C.S.12
Staff, R.T.13
Bracoud, L.14
Shamsi, K.15
Storey, J.M.16
Harrington, C.R.17
Wischik, C.M.18
-
45
-
-
79957803165
-
Masitinib as an adjunct therapy for mild-To-moderate Alzheimer's disease: A randomised, placebo-controlled phase 2 trial
-
Piette F, Belmin J,Vincent H, Schmidt N, Pariel S,VernyM, Marquis C, Mely J, Hugonot-Diener L, Kinet JP, Dubreuil P, Moussy A, Hermine O (2011) Masitinib as an adjunct therapy for mild-To-moderate Alzheimer's disease: A randomised, placebo-controlled phase 2 trial. Alzheimers Res Ther 3, 16.
-
(2011)
Alzheimers Res Ther
, vol.3
, pp. 16
-
-
Piette, F.1
Belmin Jvincent, H.2
Schmidt, N.3
Pariel, S.4
Verny, M.5
Marquis, C.6
Mely, J.7
Hugonot-Diener, L.8
Kinet, J.P.9
Dubreuil, P.10
Moussy, A.11
Hermine, O.12
-
47
-
-
84961291728
-
A Food and Drug Administration-Approved asthma therapeutic agent impacts amyloid beta in the brain in a transgenic model of Alzheimer disease
-
Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E (2015) A Food and Drug Administration-Approved asthma therapeutic agent impacts amyloid beta in the brain in a transgenic model of Alzheimer disease. J Biol Chem 290, 1966-1978.
-
(2015)
J Biol Chem
, vol.290
, pp. 1966-1978
-
-
Hori, Y.1
Takeda, S.2
Cho, H.3
Wegmann, S.4
Shoup, T.M.5
Takahashi, K.6
Irimia, D.7
Elmaleh, D.R.8
Hyman, B.T.9
Hudry, E.10
-
48
-
-
44449128155
-
The antioxidant properties of serum albumin
-
Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E (2008) The antioxidant properties of serum albumin. FEBS Lett 582, 1783-1787.
-
(2008)
FEBS Lett
, vol.582
, pp. 1783-1787
-
-
Roche, M.1
Rondeau, P.2
Singh, N.R.3
Tarnus, E.4
Bourdon, E.5
-
49
-
-
84903805358
-
Treatment of Alzheimer disease using combination therapy with plasma exchange and haemapheresis with albumin and intravenous immunoglobulin: Rationale and treatment approach of the AMBAR (Alzheimer Management by Albumin Replacement) study
-
Boada M, Ramos-Fernandez E, Guivernau B, Munoz FJ, Costa M, Ortiz AM, Jorquera JI, Nunez L, Torres M, Paez A (2016) Treatment of Alzheimer disease using combination therapy with plasma exchange and haemapheresis with albumin and intravenous immunoglobulin: Rationale and treatment approach of the AMBAR (Alzheimer Management By Albumin Replacement) study. Neurologia 31, 473-481.
-
(2016)
Neurologia
, vol.31
, pp. 473-481
-
-
Boada, M.1
Ramos-Fernandez, E.2
Guivernau, B.3
Munoz, F.J.4
Costa, M.5
Ortiz, A.M.6
Jorquera, J.I.7
Nunez, L.8
Torres, M.9
Paez, A.10
-
50
-
-
84861050637
-
Is RAGE still a therapeutic target for Alzheimer's disease?
-
Deane RJ (2012) Is RAGE still a therapeutic target for Alzheimer's disease? Future Med Chem 4, 915-925.
-
(2012)
Future Med Chem
, vol.4
, pp. 915-925
-
-
Deane, R.J.1
-
52
-
-
85061767303
-
Antipsychotic use in elderly patients with dementia: Efficacy and safety concerns
-
Marvanova M (2014) Antipsychotic use in elderly patients with dementia: Efficacy and safety concerns. Mental Health Clin 4, 170-176.
-
(2014)
Mental Health Clin
, vol.4
, pp. 170-176
-
-
Marvanova, M.1
-
53
-
-
79955821239
-
Efficacy and tolerability of antidepressants in the treatment of behavioral and psychological symptoms of dementia, a literature review of evidence
-
Henry G, Williamson D, Tampi RR (2011) Efficacy and tolerability of antidepressants in the treatment of behavioral and psychological symptoms of dementia, a literature review of evidence. Am J Alzheimers Dis Other Demen 26, 169-183.
-
(2011)
Am J Alzheimers Dis Other Demen
, vol.26
, pp. 169-183
-
-
Henry, G.1
Williamson, D.2
Tampi, R.R.3
-
54
-
-
33645527991
-
The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease
-
Ballard C, Waite J. (2006) The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease. Cochrane Database Syst Rev, CD003476.
-
(2006)
Cochrane Database Syst Rev
, pp. CD003476
-
-
Ballard, C.1
Waite, J.2
-
55
-
-
33749618085
-
CATIE-AD Study Group 2006 Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease
-
Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, Lebowitz BD, Lyketsos CG, Ryan JM, Stroup TS, Sultzer DL, Weintraub D, Lieberman JA, CATIE-AD Study Group (2006) Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. N Engl J Med 355, 1525-1538.
-
N Engl J Med
, vol.355
, pp. 1525-1538
-
-
Schneider, L.S.1
Tariot, P.N.2
Dagerman, K.S.3
Davis, S.M.4
Hsiao, J.K.5
Ismail, M.S.6
Lebowitz, B.D.7
Lyketsos, C.G.8
Ryan, J.M.9
Stroup, T.S.10
Sultzer, D.L.11
Weintraub, D.12
Lieberman, J.A.13
-
56
-
-
25844449630
-
Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia
-
Layton D, Harris S, Wilton LV, Shakir SA (2005) Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia. J Psychopharmacol 19, 473-482.
-
(2005)
J Psychopharmacol
, vol.19
, pp. 473-482
-
-
Layton, D.1
Harris, S.2
Wilton, L.V.3
Shakir, S.A.4
-
57
-
-
34547464547
-
-
Risperidal 2009 risperidone, Ortho-McNeil-Janssen Pharmaceuticals Inc, Titusville, NJ
-
Risperidal (2009) (risperidone). Full Prescribing Information, Ortho-McNeil-Janssen Pharmaceuticals Inc, Titusville, NJ.
-
Full Prescribing Information
-
-
-
58
-
-
85061798094
-
Olanzapine
-
ZYPREXA, Eli Lilly and Company, Indianapolis, IN
-
ZYPREXA (2018) (olanzapine). Full Prescribing Information, Eli Lilly and Company, Indianapolis, IN.
-
(2018)
Full Prescribing Information
-
-
-
59
-
-
34250631300
-
Antipsychotic drug use and mortality in older adults with dementia
-
Gill SS, Bronskill SE, Normand SL, Anderson GM, Sykora K, Lam K, Bell CM, Lee PE, Fischer HD, Herrmann N, Gurwitz JH, Rochon PA (2007) Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med 146, 775-786.
-
(2007)
Ann Intern Med
, vol.146
, pp. 775-786
-
-
Gill, S.S.1
Bronskill, S.E.2
Normand, S.L.3
Anderson, G.M.4
Sykora, K.5
Lam, K.6
Bell, C.M.7
Lee, P.E.8
Fischer, H.D.9
Herrmann, N.10
Gurwitz, J.H.11
Rochon, P.A.12
-
60
-
-
84992512420
-
Second generation antipsychotics in the treatment of major depressive disorder: An update
-
Wang SM, Han C, Lee SJ, Jun TY, Patkar AA, Masand PS, Pae CU (2016) Second generation antipsychotics in the treatment of major depressive disorder: An update. Chonnam Med J 52, 159-172.
-
(2016)
Chonnam Med J
, vol.52
, pp. 159-172
-
-
Wang, S.M.1
Han, C.2
Lee, S.J.3
Jun, T.Y.4
Patkar, A.A.5
Masand, P.S.6
Pae, C.U.7
-
63
-
-
85065929580
-
Effect of cholinesterase inhibitors on behavior
-
Cummings JL (2008) Effect of cholinesterase inhibitors on behavior. Neurobiol Aging 29, S6.
-
(2008)
Neurobiol Aging
, vol.29
, pp. S6
-
-
Cummings, J.L.1
-
64
-
-
84860509122
-
Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial
-
Fox C, Crugel M, Maidment I, Auestad BH, Coulton S, Treloar A, Ballard C, Boustani M, Katona C, Livingston G (2012) Efficacy of memantine for agitation in Alzheimer's dementia: A randomised double-blind placebo controlled trial. PLoS One 7, e35185.
-
(2012)
PLoS One
, vol.7
, pp. e35185
-
-
Fox, C.1
Crugel, M.2
Maidment, I.3
Auestad, B.H.4
Coulton, S.5
Treloar, A.6
Ballard, C.7
Boustani, M.8
Katona, C.9
Livingston, G.10
-
65
-
-
46749118971
-
5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease
-
Upton N, Chuang TT, Hunter AJ, Virley DJ (2008) 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics 5, 458-469.
-
(2008)
Neurotherapeutics
, vol.5
, pp. 458-469
-
-
Upton, N.1
Chuang, T.T.2
Hunter, A.J.3
Virley, D.J.4
-
66
-
-
84907995546
-
Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): A randomised, double-blind, placebocontrolled phase 2 trial
-
Wilkinson D, Windfeld K, Colding-Jorgensen E (2014) Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): A randomised, double-blind, placebocontrolled phase 2 trial. Lancet Neurol 13, 1092-1099.
-
(2014)
Lancet Neurol
, vol.13
, pp. 1092-1099
-
-
Wilkinson, D.1
Windfeld, K.2
Colding-Jorgensen, E.3
-
67
-
-
85040590159
-
Effect of idalopirdine as adjunct to cholinesterase inhibitors on change in cognition in patients with Alzheimer disease: Three randomized clinical trials
-
Atri A, Frolich L, Ballard C, Tariot PN, Molinuevo JL, Boneva N, Windfeld K, Raket LL, Cummings JL (2018) Effect of idalopirdine as adjunct to cholinesterase inhibitors on change in cognition in patients with Alzheimer disease: Three randomized clinical trials. JAMA 319, 130-142.
-
(2018)
JAMA
, vol.319
, pp. 130-142
-
-
Atri, A.1
Frolich, L.2
Ballard, C.3
Tariot, P.N.4
Molinuevo, J.L.5
Boneva, N.6
Windfeld, K.7
Raket, L.L.8
Cummings, J.L.9
-
68
-
-
84944038299
-
Two randomized controlled trials of SB742457 in mild-Tomoderate Alzheimer's disease
-
Maher-Edwards G,Watson C, Ascher J, Barnett C, Boswell D, Davies J, Fernandez M, Kurz A, Zanetti O, Safirstein B, Schronen JP, Zvartau-Hind M, Gold M (2015) Two randomized controlled trials of SB742457 in mild-Tomoderate Alzheimer's disease. Alzheimers Dement (N Y) 1, 23-36.
-
(2015)
Alzheimers Dement (N y
, vol.1
, pp. 23-36
-
-
Maher-Edwards, G.1
Watson, C.2
Ascher, J.3
Barnett, C.4
Boswell, D.5
Davies, J.6
Fernandez, M.7
Kurz, A.8
Zanetti, O.9
Safirstein, B.10
Schronen, J.P.11
Zvartau-Hind, M.12
Gold, M.13
-
71
-
-
0035130289
-
Rasagiline [N-propargyl-1R(+)-Aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B
-
Youdim MB, Gross A, Finberg JP (2001) Rasagiline [N-propargyl-1R(+)-Aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br J Pharmacol 132, 500-506.
-
(2001)
Br J Pharmacol
, vol.132
, pp. 500-506
-
-
Youdim, M.B.1
Gross, A.2
Finberg, J.P.3
-
72
-
-
12244296145
-
Rasagiline: Neurodegeneration, neuroprotection, and mitochondrial permeability transition
-
Youdim MB, Bar Am O, Yogev-Falach M, Weinreb O, Maruyama W, Naoi M, Amit T (2005) Rasagiline: Neurodegeneration, neuroprotection, and mitochondrial permeability transition. J Neurosci Res 79, 172-179.
-
(2005)
J Neurosci Res
, vol.79
, pp. 172-179
-
-
Youdim, M.B.1
Bar Am, O.2
Yogev-Falach, M.3
Weinreb, O.4
Maruyama, W.5
Naoi, M.6
Amit, T.7
-
74
-
-
84964658606
-
Challenges, solutions, and recommendations for Alzheimer's disease combination therapy
-
Hendrix JA, Bateman RJ, Brashear HR, Duggan C, Carrillo MC, Bain LJ, DeMattos R, Katz RG, Ostrowitzki S, Siemers E, Sperling R, Vitolo OV (2016) Challenges, solutions, and recommendations for Alzheimer's disease combination therapy. Alzheimers Dement 12, 623-630.
-
(2016)
Alzheimers Dement
, vol.12
, pp. 623-630
-
-
Hendrix, J.A.1
Bateman, R.J.2
Brashear, H.R.3
Duggan, C.4
Carrillo, M.C.5
Bain, L.J.6
DeMattos, R.7
Katz, R.G.8
Ostrowitzki, S.9
Siemers, E.10
Sperling, R.11
Vitolo, O.V.12
-
75
-
-
77953047033
-
Clinical trial structures
-
Evans SR (2010) Clinical trial structures. J Exp Stroke Transl Med 3, 8-18.
-
(2010)
J Exp Stroke Transl Med
, vol.3
, pp. 8-18
-
-
Evans, S.R.1
-
76
-
-
85029581377
-
I-SPY 2 breast cancer trial as a model for innovation in Alzheimer disease therapies
-
Messmer MF, Wilhelm EE, Shoulson I (2017) I-SPY 2 breast cancer trial as a model for innovation in Alzheimer disease therapies. JAMA Neurol 74, 1027-1028.
-
(2017)
JAMA Neurol
, vol.74
, pp. 1027-1028
-
-
Messmer, M.F.1
Wilhelm, E.E.2
Shoulson, I.3
-
80
-
-
84957440529
-
European prevention of Alzheimer's dementia consortium
-
Development of interventions for the secondary prevention of Alzheimer's dementia: The European Prevention of Alzheimer's Dementia (EPAD) project
-
Ritchie CW, Molinuevo JL, Truyen L, Satlin A, Van der Geyten S, Lovestone S, European Prevention of Alzheimer's Dementia Consortium (2016) Development of interventions for the secondary prevention of Alzheimer's dementia: The European Prevention of Alzheimer's Dementia (EPAD) project. Lancet Psychiatry 3, 179-186.
-
(2016)
Lancet Psychiatry
, vol.3
, pp. 179-186
-
-
Ritchie, C.W.1
Molinuevo, J.L.2
Truyen, L.3
Satlin, A.4
Van Der Geyten, S.5
Lovestone, S.6
-
81
-
-
85061805991
-
-
European Medicines Agency, Accessed on June 7
-
European Medicines Agency, Guideline on clinical development of fixed combination medicinal products, http://www. ema.europa.eu/docs/en GB/document library/Scientific gu ideline/2017/03/WC500224836.pdf, Accessed on June 7, 2018.
-
(2018)
Guideline on Clinical Development of Fixed Combination Medicinal Products
-
-
-
83
-
-
85026502234
-
Combination products: Modernizing the regulatory paradigm
-
Hunter NL, Sherman RE (2017) Combination products: Modernizing the regulatory paradigm. Nat Rev Drug Discov 16, 513-514.
-
(2017)
Nat Rev Drug Discov
, vol.16
, pp. 513-514
-
-
Hunter, N.L.1
Sherman, R.E.2
|