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Volumn 136, Issue 8, 2013, Pages 2510-2526

Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology

Author keywords

Alzheimers disease; Amyloid pathology; Astrocytes; Microglia; Resilience; Tau pathology

Indexed keywords

AMYLOID BETA PROTEIN; CD68 ANTIGEN;

EID: 84880964331     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awt171     Document Type: Article
Times cited : (280)

References (62)
  • 2
    • 84872915600 scopus 로고    scopus 로고
    • United states life tables, 2008
    • Arias E. United States life tables, 2008. Natl Vital Stat Rep 2012; 61: 3.
    • (2012) Natl Vital Stat Rep , vol.61 , pp. 3
    • Arias, E.1
  • 3
    • 84868099498 scopus 로고    scopus 로고
    • Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
    • Arnold SE, Louneva N, Cao K, Wang LS, Han LY, Wolk DA, et al. Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease. Neurobiol Aging 2013; 34: 157-68.
    • (2013) Neurobiol Aging , vol.34 , pp. 157-168
    • Arnold, S.E.1    Louneva, N.2    Cao, K.3    Wang, L.S.4    Han, L.Y.5    Wolk, D.A.6
  • 4
    • 0026743110 scopus 로고
    • Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
    • Arriagada PV, Marzloff K, Hyman BT. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology 1992; 42: 1681-88.
    • (1992) Neurology , vol.42 , pp. 1681-1688
    • Arriagada, P.V.1    Marzloff, K.2    Hyman, B.T.3
  • 5
    • 84857642949 scopus 로고    scopus 로고
    • The toxic Abeta oligomer and Alzheimer's disease: An emperor in need of clothes
    • Benilova I, Karran E, De SB. The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 2012; 15: 349-57.
    • (2012) Nat Neurosci , vol.15 , pp. 349-357
    • Benilova, I.1    Karran, E.2    De, S.B.3
  • 6
    • 34147125835 scopus 로고    scopus 로고
    • Accumulation of pathological tau species and memory loss in a conditional model of tauopathy
    • Berger Z, Roder H, Hanna A, Carlson A, Rangachari V, Yue M, et al. Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. J Neurosci 2007; 27: 3650-62.
    • (2007) J Neurosci , vol.27 , pp. 3650-3662
    • Berger, Z.1    Roder, H.2    Hanna, A.3    Carlson, A.4    Rangachari, V.5    Yue, M.6
  • 7
    • 77952545096 scopus 로고    scopus 로고
    • Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease
    • Coma M, Sereno L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, et al. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2010; 38: 482-91.
    • (2010) Neurobiol Dis , vol.38 , pp. 482-491
    • Coma, M.1    Sereno, L.2    Da Rocha-Souto, B.3    Scotton, T.C.4    España, J.5    Sánchez, M.B.6
  • 8
    • 0037312858 scopus 로고    scopus 로고
    • In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories
    • D'Amore JD, Kajdasz ST, McLellan ME, Bacskai BJ, Stern EA, Hyman BT. In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. J Neuropathol Exp Neurol 2003; 62: 137-45.
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 137-145
    • D'Amore, J.D.1    Kajdasz, S.T.2    McLellan, M.E.3    Bacskai, B.J.4    Stern, E.A.5    Hyman, B.T.6
  • 9
    • 81955167913 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase-3 beta mediates beta-amyloid induced neuritic damage in Alzheimer's disease
    • DaRocha-Souto B, Coma M, Perez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, et al. Activation of glycogen synthase kinase-3 beta mediates beta-amyloid induced neuritic damage in Alzheimer's disease. Neurobiol Dis 2012; 45: 425-37.
    • (2012) Neurobiol Dis , vol.45 , pp. 425-437
    • Darocha-Souto, B.1    Coma, M.2    Perez-Nievas, B.G.3    Scotton, T.C.4    Siao, M.5    Sánchez-Ferrer, P.6
  • 10
    • 79955524573 scopus 로고    scopus 로고
    • Brain oligomeric beta-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice
    • DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, et al. Brain oligomeric beta-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. J Neuropathol Exp Neurol 2011; 70: 360-76.
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 360-376
    • Darocha-Souto, B.1    Scotton, T.C.2    Coma, M.3    Serrano-Pozo, A.4    Hashimoto, T.5    Serenó, L.6
  • 13
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • Dekosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990; 27: 457-64.
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • Dekosky, S.T.1    Scheff, S.W.2
  • 14
    • 0035898257 scopus 로고    scopus 로고
    • The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease
    • Dickson TC, Vickers JC. The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience 2001; 105: 99-107.
    • (2001) Neuroscience , vol.105 , pp. 99-107
    • Dickson, T.C.1    Vickers, J.C.2
  • 16
    • 84869016768 scopus 로고    scopus 로고
    • Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease
    • Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, et al. Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J Neurosci 2012; 32: 16129-40.
    • (2012) J Neurosci , vol.32 , pp. 16129-16140
    • Furman, J.L.1    Sama, D.M.2    Gant, J.C.3    Beckett, T.L.4    Murphy, M.P.5    Bachstetter, A.D.6
  • 17
    • 0038708285 scopus 로고    scopus 로고
    • Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
    • Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Kövari E, Perl DP, et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 2003; 60: 1495-1500.
    • (2003) Neurology , vol.60 , pp. 1495-1500
    • Giannakopoulos, P.1    Herrmann, F.R.2    Bussiere, T.3    Bouras, C.4    Kövari, E.5    Perl, D.P.6
  • 18
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    • Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997; 41: 17-24.
    • (1997) Ann Neurol , vol.41 , pp. 17-24
    • Gomez-Isla, T.1    Hollister, R.2    West, H.3    Mui, S.4    Growdon, J.H.5    Petersen, R.C.6
  • 22
    • 70349558522 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    • Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009; 41: 1088-93.
    • (2009) Nat Genet , vol.41 , pp. 1088-1093
    • Harold, D.1    Abraham, R.2    Hollingworth, P.3    Sims, R.4    Gerrish, A.5    Hamshere, M.L.6
  • 23
    • 84867797446 scopus 로고    scopus 로고
    • Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide
    • Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, et al. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid beta peptide. J Neurosci 2012; 32: 15181-92.
    • (2012) J Neurosci , vol.32 , pp. 15181-15192
    • Hashimoto, T.1    Serrano-Pozo, A.2    Hori, Y.3    Adams, K.W.4    Takeda, S.5    Banerji, A.O.6
  • 24
    • 70349336015 scopus 로고    scopus 로고
    • The nun study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life
    • Iacono D, Markesbery WR, Gross M, Pletnikova O, Rudow G, Zandi P, et al. The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life. Neurology 2009; 73: 665-73.
    • (2009) Neurology , vol.73 , pp. 665-673
    • Iacono, D.1    Markesbery, W.R.2    Gross, M.3    Pletnikova, O.4    Rudow, G.5    Zandi, P.6
  • 26
    • 43849083580 scopus 로고    scopus 로고
    • Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    • Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008; 131: 1630-45.
    • (2008) Brain , vol.131 , pp. 1630-1645
    • Ikonomovic, M.D.1    Klunk, W.E.2    Abrahamson, E.E.3    Mathis, C.A.4    Price, J.C.5    Tsopelas, N.D.6
  • 27
    • 0030611097 scopus 로고    scopus 로고
    • Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
    • Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, et al. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 1997; 17: 7053-9.
    • (1997) J Neurosci , vol.17 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6
  • 30
    • 0141705380 scopus 로고    scopus 로고
    • Essentials of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia
    • Knopman DS, Boeve BF, Petersen RC. Essentials of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia. Mayo Clin Proc 2003; 78: 1290-308.
    • (2003) Mayo Clin Proc , vol.78 , pp. 1290-1308
    • Knopman, D.S.1    Boeve, B.F.2    Petersen, R.C.3
  • 31
    • 0033609008 scopus 로고    scopus 로고
    • Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer's disease
    • Knowles RB, Wyart C, Buldyrev SV, Cruz L, Urbanc B, Hasselmo ME, et al. Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease. Proc Natl Acad Sci USA 1999; 96: 5274-9.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5274-5279
    • Knowles, R.B.1    Wyart, C.2    Buldyrev, S.V.3    Cruz, L.4    Urbanc, B.5    Hasselmo, M.E.6
  • 32
    • 84863192724 scopus 로고    scopus 로고
    • Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta
    • Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, et al. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta. Brain 2012; 135: 2155-68.
    • (2012) Brain , vol.135 , pp. 2155-2168
    • Koffie, R.M.1    Hashimoto, T.2    Tai, H.C.3    Kay, K.R.4    Serrano-Pozo, A.5    Joyner, D.6
  • 33
    • 62649174753 scopus 로고    scopus 로고
    • Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
    • Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, et al. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proc Natl Acad Sci USA 2009; 106: 4012-7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 4012-4017
    • Koffie, R.M.1    Meyer-Luehmann, M.2    Hashimoto, T.3    Adams, K.W.4    Mielke, M.L.5    Garcia-Alloza, M.6
  • 34
    • 70349576339 scopus 로고    scopus 로고
    • Association of plasma amyloid beta with risk of dementia: The prospective Three-City Study
    • Lambert JC, Schraen-Maschke S, Richard F, Fievet N, Rouaud O, Berr C, et al. Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study. Neurology 2009; 73: 847-53.
    • (2009) Neurology , vol.73 , pp. 847-853
    • Lambert, J.C.1    Schraen-Maschke, S.2    Richard, F.3    Fievet, N.4    Rouaud, O.5    Berr, C.6
  • 36
    • 0034918436 scopus 로고    scopus 로고
    • Plaqueinduced abnormalities in neurite geometry in transgenic models of Alzheimer disease: Implications for neural system disruption
    • Le R, Cruz L, Urbanc B, Knowles RB, Hsiao-Ashe K, Duff K, et al. Plaqueinduced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. J Neuropathol Exp Neurol 2001; 60: 753-8.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 753-758
    • Le, R.1    Cruz, L.2    Urbanc, B.3    Knowles, R.B.4    Hsiao-Ashe, K.5    Duff, K.6
  • 37
    • 33645220400 scopus 로고    scopus 로고
    • Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    • Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, et al. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J Biol Chem 2006; 281: 4292-9.
    • (2006) J Biol Chem , vol.281 , pp. 4292-4299
    • Lee, E.B.1    Leng, L.Z.2    Zhang, B.3    Kwong, L.4    Trojanowski, J.Q.5    Abel, T.6
  • 39
    • 34848885454 scopus 로고    scopus 로고
    • PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis
    • Lockhart A, Lamb JR, Osredkar T, Sue LI, Joyce JN, Ye L, et al. PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. Brain 2007; 130: 2607-15.
    • (2007) Brain , vol.130 , pp. 2607-2615
    • Lockhart, A.1    Lamb, J.R.2    Osredkar, T.3    Sue, L.I.4    Joyce, J.N.5    Ye, L.6
  • 40
    • 33644876596 scopus 로고    scopus 로고
    • Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: A comparative analysis
    • Lopresti BJ, Klunk WE, Mathis CA, Hoge JA, Ziolko SK, Lu X, et al. Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis. J Nucl Med 2005; 46: 1959-72.
    • (2005) J Nucl Med , vol.46 , pp. 1959-1972
    • Lopresti, B.J.1    Klunk, W.E.2    Mathis, C.A.3    Hoge, J.A.4    Ziolko, S.K.5    Lu, X.6
  • 41
    • 77951928742 scopus 로고    scopus 로고
    • The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia
    • Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, et al. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain 2010; 133: 1328-41.
    • (2010) Brain , vol.133 , pp. 1328-1341
    • Mc Donald, J.M.1    Savva, G.M.2    Brayne, C.3    Welzel, A.T.4    Forster, G.5    Shankar, G.M.6
  • 43
    • 0029917887 scopus 로고    scopus 로고
    • Anti-inflammatory drugs in the fight against Alzheimer's disease
    • McGeer PL, McGeer EG. Anti-inflammatory drugs in the fight against Alzheimer's disease. Ann N Y Acad Sci 1996; 777: 213-20.
    • (1996) Ann N y Acad Sci , vol.777 , pp. 213-220
    • McGeer, P.L.1    McGeer, E.G.2
  • 44
    • 33847339301 scopus 로고    scopus 로고
    • NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
    • McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiol Aging 2007; 28: 639-47.
    • (2007) Neurobiol Aging , vol.28 , pp. 639-647
    • McGeer, P.L.1    McGeer, E.G.2
  • 45
    • 33747048954 scopus 로고    scopus 로고
    • [11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
    • Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, et al. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006; 67: 446-52.
    • (2006) Neurology , vol.67 , pp. 446-452
    • Mintun, M.A.1    Larossa, G.N.2    Sheline, Y.I.3    Dence, C.S.4    Lee, S.Y.5    MacH, R.H.6
  • 46
    • 0029892175 scopus 로고    scopus 로고
    • Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease
    • Morris JC, Storandt M, McKeel DW Jr, Rubin EH, Price JL, Grant EA, et al. Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease. Neurology 1996; 46: 707-19.
    • (1996) Neurology , vol.46 , pp. 707-719
    • Morris, J.C.1    Storandt, M.2    McKeel Jr., D.W.3    Rubin, E.H.4    Price, J.L.5    Grant, E.A.6
  • 47
    • 11444250354 scopus 로고    scopus 로고
    • Early life linguistic ability, late life cognitive function, and neuropathology: Findings from the Nun Study
    • Riley KP, Snowdon DA, Desrosiers MF, Markesbery WR. Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study. Neurobiol Aging 2005; 26: 341-7.
    • (2005) Neurobiol Aging , vol.26 , pp. 341-347
    • Riley, K.P.1    Snowdon, D.A.2    Desrosiers, M.F.3    Markesbery, W.R.4
  • 49
    • 0345276568 scopus 로고    scopus 로고
    • Synaptic pathology in Alzheimer's disease: A review of ultrastructural studies
    • Scheff SW, Price DA. Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies. Neurobiol Aging 2003; 24: 1029-46.
    • (2003) Neurobiol Aging , vol.24 , pp. 1029-1046
    • Scheff, S.W.1    Price, D.A.2
  • 50
    • 75149172921 scopus 로고    scopus 로고
    • The neuropathology of older persons with and without dementia from community versus clinic cohorts
    • Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis 2009; 18: 691-701.
    • (2009) J Alzheimers Dis , vol.18 , pp. 691-701
    • Schneider, J.A.1    Aggarwal, N.T.2    Barnes, L.3    Boyle, P.4    Bennett, D.A.5
  • 51
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 1991; 6: 487-98.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 53
    • 77951893095 scopus 로고    scopus 로고
    • Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology
    • Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, et al. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain 2010; 133: 1312-27.
    • (2010) Brain , vol.133 , pp. 1312-1327
    • Serrano-Pozo, A.1    William, C.M.2    Ferrer, I.3    Uro-Coste, E.4    Delisle, M.B.5    Maurage, C.A.6
  • 54
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 2008; 14: 837-42.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 55
    • 23444448170 scopus 로고    scopus 로고
    • Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
    • Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci 2005; 25: 7278-87.
    • (2005) J Neurosci , vol.25 , pp. 7278-7287
    • Spires, T.L.1    Meyer-Luehmann, M.2    Stern, E.A.3    McLean, P.J.4    Skoch, J.5    Nguyen, P.T.6
  • 57
    • 84866478442 scopus 로고    scopus 로고
    • The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system
    • Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol 2012; 181: 1426-35.
    • (2012) Am J Pathol , vol.181 , pp. 1426-1435
    • Tai, H.C.1    Serrano-Pozo, A.2    Hashimoto, T.3    Frosch, M.P.4    Spires-Jones, T.L.5    Hyman, B.T.6
  • 58
    • 68149162581 scopus 로고    scopus 로고
    • Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
    • Tomic JL, Pensalfini A, Head E, Glabe CG. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis 2009; 35: 352-8.
    • (2009) Neurobiol Dis , vol.35 , pp. 352-358
    • Tomic, J.L.1    Pensalfini, A.2    Head, E.3    Glabe, C.G.4
  • 59
    • 70350662460 scopus 로고    scopus 로고
    • Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease
    • Van Exel E, Eikelenboom P, Comijs H, Frölich M, Smit JH, Stek ML, et al. Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease. Arch Gen Psychiatry 2009; 66: 1263-70.
    • (2009) Arch Gen Psychiatry , vol.66 , pp. 1263-1270
    • Van Exel, E.1    Eikelenboom, P.2    Comijs, H.3    Frölich, M.4    Smit, J.H.5    Stek, M.L.6
  • 60
    • 84876216611 scopus 로고    scopus 로고
    • Oligomers, fact or artefact? SDS-PAGE induces dimerization of beta-amyloid in human brain samples
    • Watt AD, Perez KA, Rembach A, Sherrat NA, Hung LW, Johanssen T, et al. Oligomers, fact or artefact? SDS-PAGE induces dimerization of beta-amyloid in human brain samples. Acta Neuropathol 2013; 125: 549-64.
    • (2013) Acta Neuropathol , vol.125 , pp. 549-564
    • Watt, A.D.1    Perez, K.A.2    Rembach, A.3    Sherrat, N.A.4    Hung, L.W.5    Johanssen, T.6
  • 61
    • 0025327731 scopus 로고
    • Unbiased stereological estimation of the number of neurons in the human hippocampus
    • West MJ, Gundersen HJ. Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 1990; 296: 1-22.
    • (1990) J Comp Neurol , vol.296 , pp. 1-22
    • West, M.J.1    Gundersen, H.J.2
  • 62
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: Driving force, bystander or beneficial response?
    • Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 2006; 12: 1005-15.
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.