Amyloid-β binds to the extracellular cysteine-rich domain of frizzled and inhibits Wnt/β-catenin signaling

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 9359-9368

  Magdesian, Margaret H ^a   Carvalho, Milena M V F ^a   Mendes, Fabio A ^a   Saraiva, Leonardo M ^a   Juliano, Maria A ^b   Juliano, Luiz ^b   Garcia Abreu, José ^a   Ferreira, Sérgio T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BINDING ENERGY; FLOW INTERACTIONS; GLYCOPROTEINS; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASES; CANONICAL WNT SIGNALING; CATENIN SIGNALING; CLOSE PROXIMITIES; DO-MAINS; EXTRACELLULAR; HEPTAPEPTIDE; HIGH AFFINITIES; NEURONAL DYSFUNCTIONS; NEUROTOXICITY; PEPTIDE LIBRARIES; PHAGE DISPLAYS; PROTEIN RECEPTORS; RELEVANT TARGETS; SIGNAL TRANSDUCTION MECHANISMS;

BINDING SITES;

AMYLOID BETA PROTEIN; BETA CATENIN; CYSTEINE RICH PROTEIN 61; FRIZZLED PROTEIN; WNT PROTEIN; OLIGOPEPTIDE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; ALZHEIMER DISEASE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BETA CATENIN; BINDING SITES; CELL LINE; FRIZZLED RECEPTORS; HUMANS; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 44049089139     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707108200     Document Type: Article

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