Amyloid in Alzheimer's Disease: Guilty Beyond Reasonable Doubt?

Trends in Pharmacological Sciences

Volumn 38, Issue 10, 2017, Pages 849-851

  Behl, Christian ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID;

ALZHEIMER DISEASE; AUTOPHAGY; CLINICAL ASSESSMENT; CLINICAL RESEARCH; HUMAN; HYPOTHESIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RISK FACTOR; SHORT SURVEY; THERAPY EFFECT; TRANSGENIC MOUSE; ANIMAL; METABOLISM; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID; ANIMALS; HUMANS;

EID: 85027585635     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2017.07.002     Document Type: Short Survey

References (14)

1. Selkoe, D.J., Hardy, J., The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol. Med. 8 (2016), 595–608.
2. Winblad, B., et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. Lancet Neurol. 15 (2016), 455–532.
3. Herrup, K., The case for rejecting the amyloid cascade hypothesis. Nat. Neurosci. 18 (2015), 794–799.
4. Terry, R.D., The pathogenesis of Alzheimer disease: an alternative to the amyloid hypothesis. J. Neuropathol. Exp. Neurol. 55 (1996), 1023–1025.
5. Neve, R.L., Robakis, N.K., Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci. 21 (1998), 15–19.
6. Sevigny, J., et al. The antibody aducanumab reduces A β plaques in Alzheimer's disease. Nature 537 (2016), 50–56.
7. Gamerdinger, M., et al. Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3. EMBO J. 28 (2009), 889–901.
8. Pimplikar, S.W., et al. Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J. Neurosci. 30 (2010), 14946–14954.
9. Bordi, M., et al. Autophagy flux in CA1 neurons of Alzheimer hippocampus: increased induction overburdens failing lysosomes to propel neuritic dystrophy. Autophagy 12 (2016), 2467–2483.
10. Guerreiro, R., et al. Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer's disease. N. Engl. J. Med. 368 (2013), 117–127.
11. Jonsson, T., et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N. Engl. J. Med. 368 (2013), 107–116.
12. Ulrich, J.D., et al. Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Mol. Neurodegener., 9, 2014, 20.
13. Kleinberger, G., et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. EMBO J., 2017 e201796516.
14. Lucin, K.M., et al. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79 (2013), 873–886.