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Volumn 7, Issue 12, 2018, Pages

The winding road of cardiac regeneration—Stem cell omics in the spotlight

Author keywords

Cardiac regeneration; Cardioprotection; Omics data; Precision medicine; Stem cells

Indexed keywords

ANGIOPOIETIN 1; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 6; LERCANIDIPINE; LONG UNTRANSLATED RNA; MICRORNA; MICRORNA 126; MICRORNA 146A; MICRORNA 181B; MICRORNA 199A; MICRORNA 208; MICRORNA 21; MICRORNA 210; MICRORNA 22; MICRORNA 221; MICRORNA 24; MICRORNA 291; MICRORNA 294; MICRORNA 30B; MICRORNA 30C; S ADENOSYLMETHIONINE; SCATTER FACTOR; SOMATOMEDIN C RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 85065567155     PISSN: None     EISSN: 20734409     Source Type: Journal    
DOI: 10.3390/cells7120255     Document Type: Review
Times cited : (9)

References (186)
  • 3
    • 85041741168 scopus 로고    scopus 로고
    • Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction
    • Micheu, M.M.; Dorobantu, M. Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction. World J. Stem Cell 2017, 9, 68–76.
    • (2017) World J. Stem Cell , vol.9 , pp. 68-76
    • Micheu, M.M.1    Dorobantu, M.2
  • 4
    • 85041731324 scopus 로고    scopus 로고
    • Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease
    • Dorobantu, M.; Popa-Fotea, N.M.; Popa, M.; Rusu, I.; Micheu, M.M. Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease. World J. Stem Cell 2017, 9, 203–218.
    • (2017) World J. Stem Cell , vol.9 , pp. 203-218
    • Dorobantu, M.1    Popa-Fotea, N.M.2    Popa, M.3    Rusu, I.4    Micheu, M.M.5
  • 5
  • 6
    • 85048024801 scopus 로고    scopus 로고
    • Concise Review: Assessing the Genome Integrity of Human Induced Pluripotent Stem Cells: What Quality Control Metrics?
    • Assou, S.; Bouckenheimer, J.; De Vos, J. Concise Review: Assessing the Genome Integrity of Human Induced Pluripotent Stem Cells: What Quality Control Metrics? Stem Cells 2018, 36, 814–821.
    • (2018) Stem Cells , vol.36 , pp. 814-821
    • Assou, S.1    Bouckenheimer, J.2    de Vos, J.3
  • 7
    • 84984903623 scopus 로고    scopus 로고
    • Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications
    • Yoshihara, M.; Hayashizaki, Y.; Murakawa, Y. Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications. Stem Cell Rev. 2017, 13, 7–16.
    • (2017) Stem Cell Rev , vol.13 , pp. 7-16
    • Yoshihara, M.1    Hayashizaki, Y.2    Murakawa, Y.3
  • 12
    • 84892498732 scopus 로고    scopus 로고
    • Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL
    • Nguyen, H.T.; Geens, M.; Mertzanidou, A.; Jacobs, K.; Heirman, C.; Breckpot, K.; Spits, C. Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL. Mol. Hum. Reprod. 2014, 20, 168–177.
    • (2014) Mol. Hum. Reprod. , vol.20 , pp. 168-177
    • Nguyen, H.T.1    Geens, M.2    Mertzanidou, A.3    Jacobs, K.4    Heirman, C.5    Breckpot, K.6    Spits, C.7
  • 15
    • 79961138790 scopus 로고    scopus 로고
    • Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells
    • Ben-David, U.; Mayshar, Y.; Benvenisty, N. Large-scale analysis reveals acquisition of lineage-specific chromosomal aberrations in human adult stem cells. Cell Stem Cell 2011, 9, 97–102.
    • (2011) Cell Stem Cell , vol.9 , pp. 97-102
    • Ben-David, U.1    Mayshar, Y.2    Benvenisty, N.3
  • 16
    • 77954833815 scopus 로고    scopus 로고
    • Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells
    • Li, T.S.; Marban, E. Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells. Stem Cell. 2010, 28, 1178–1185.
    • (2010) Stem Cell , vol.28 , pp. 1178-1185
    • Li, T.S.1    Marban, E.2
  • 17
    • 78650454196 scopus 로고    scopus 로고
    • Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair
    • Li, T.S.; Cheng, K.; Malliaras, K.; Matsushita, N.; Sun, B.; Marban, L.; Zhang, Y.; Marban, E. Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair. Cardiovasc. Res. 2011, 89, 157–165.
    • (2011) Cardiovasc. Res. , vol.89 , pp. 157-165
    • Li, T.S.1    Cheng, K.2    Malliaras, K.3    Matsushita, N.4    Sun, B.5    Marban, L.6    Zhang, Y.7    Marban, E.8
  • 18
    • 84907906057 scopus 로고    scopus 로고
    • Concise review: Genomic instability in human stem cells: Current status and future challenges
    • Oliveira, P.H.; da Silva, C.L.; Cabral, J.M. Concise review: Genomic instability in human stem cells: Current status and future challenges. Stem Cell. 2014, 32, 2824–2832.
    • (2014) Stem Cell , vol.32 , pp. 2824-2832
    • Oliveira, P.H.1    da Silva, C.L.2    Cabral, J.M.3
  • 19
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    • Laurent, L.C.; Ulitsky, I.; Slavin, I.; Tran, H.; Schork, A.; Morey, R.; Lynch, C.; Harness, J.V.; Lee, S.; Barrero, M.J.; et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 2011, 8, 106–118.
    • (2011) Cell Stem Cell , vol.8 , pp. 106-118
    • Laurent, L.C.1    Ulitsky, I.2    Slavin, I.3    Tran, H.4    Schork, A.5    Morey, R.6    Lynch, C.7    Harness, J.V.8    Lee, S.9    Barrero, M.J.10
  • 20
    • 84924219919 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells
    • Cai, J.; Miao, X.; Li, Y.; Smith, C.; Tsang, K.; Cheng, L.; Wang, Q.F. Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells. Stem Cell Rep. 2014, 3, 227–233.
    • (2014) Stem Cell Rep , vol.3 , pp. 227-233
    • Cai, J.1    Miao, X.2    Li, Y.3    Smith, C.4    Tsang, K.5    Cheng, L.6    Wang, Q.F.7
  • 21
    • 85032982297 scopus 로고    scopus 로고
    • Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing
    • Kim, M.; Rhee, J.K.; Choi, H.; Kwon, A.; Kim, J.; Lee, G.D.; Jekarl, D.W.; Lee, S.; Kim, Y.; Kim, T.M. Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing. Sci. Rep. 2017, 7, 14508.
    • (2017) Sci. Rep. , vol.7
    • Kim, M.1    Rhee, J.K.2    Choi, H.3    Kwon, A.4    Kim, J.5    Lee, G.D.6    Jekarl, D.W.7    Lee, S.8    Kim, Y.9    Kim, T.M.10
  • 22
    • 84891797874 scopus 로고    scopus 로고
    • Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation
    • Wang, Y.; Zhang, Z.; Chi, Y.; Zhang, Q.; Xu, F.; Yang, Z.; Meng, L.; Yang, S.; Yan, S.; Mao, A.; et al. Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation. Cell Death Dis. 2013, 4, e950.
    • (2013) Cell Death Dis , vol.4 , pp. e950
    • Wang, Y.1    Zhang, Z.2    Chi, Y.3    Zhang, Q.4    Xu, F.5    Yang, Z.6    Meng, L.7    Yang, S.8    Yan, S.9    Mao, A.10
  • 24
    • 85045005258 scopus 로고    scopus 로고
    • Epigenetic modifications in the embryonic and induced pluripotent stem cells
    • Godini, R.; Lafta, H.Y.; Fallahi, H. Epigenetic modifications in the embryonic and induced pluripotent stem cells. Gene Expr. Patterns. 2018, 29, 1–9.
    • (2018) Gene Expr. Patterns. , vol.29 , pp. 1-9
    • Godini, R.1    Lafta, H.Y.2    Fallahi, H.3
  • 25
    • 69349098474 scopus 로고    scopus 로고
    • Epigenetics: Definition, mechanisms and clinical perspective
    • Dupont, C.; Armant, D.R.; Brenner, C.A. Epigenetics: Definition, mechanisms and clinical perspective. Semin. Reprod. Med. 2009, 27, 351–357.
    • (2009) Semin. Reprod. Med. , vol.27 , pp. 351-357
    • Dupont, C.1    Armant, D.R.2    Brenner, C.A.3
  • 26
    • 85007482442 scopus 로고    scopus 로고
    • Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
    • Klungland, A.; Robertson, A.B. Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine. Free Radic. Biol. Med. 2017, 107, 62–68.
    • (2017) Free Radic. Biol. Med. , vol.107 , pp. 62-68
    • Klungland, A.1    Robertson, A.B.2
  • 30
    • 33751019458 scopus 로고    scopus 로고
    • Proteomic profiling of rat bone marrow mesenchymal stem cells induced by 5-azacytidine
    • Ye, N.S.; Chen, J.; Luo, G.A.; Zhang, R.L.; Zhao, Y.F.; Wang, Y.M. Proteomic profiling of rat bone marrow mesenchymal stem cells induced by 5-azacytidine. Stem Cells Dev. 2006, 15, 665–676.
    • (2006) Stem Cells Dev , vol.15 , pp. 665-676
    • Ye, N.S.1    Chen, J.2    Luo, G.A.3    Zhang, R.L.4    Zhao, Y.F.5    Wang, Y.M.6
  • 32
    • 33645716751 scopus 로고    scopus 로고
    • Effect of 5-azacytidine on the protein expression of porcine bone marrow mesenchymal stem cells in vitro
    • Ye, N.S.; Zhang, R.L.; Zhao, Y.F.; Feng, X.; Wang, Y.M.; Luo, G.A. Effect of 5-azacytidine on the protein expression of porcine bone marrow mesenchymal stem cells in vitro. Genom. Proteom. Bioinform. 2006, 4, 18–25.
    • (2006) Genom. Proteom. Bioinform. , vol.4 , pp. 18-25
    • Ye, N.S.1    Zhang, R.L.2    Zhao, Y.F.3    Feng, X.4    Wang, Y.M.5    Luo, G.A.6
  • 33
    • 46749089254 scopus 로고    scopus 로고
    • 5-Azacytidine-treated human mesenchymal stem/progenitor cells derived from umbilical cord, cord blood and bone marrow do not generate cardiomyocytes in vitro at high frequencies
    • Martin-Rendon, E.; Sweeney, D.; Lu, F.; Girdlestone, J.; Navarrete, C.; Watt, S.M. 5-Azacytidine-treated human mesenchymal stem/progenitor cells derived from umbilical cord, cord blood and bone marrow do not generate cardiomyocytes in vitro at high frequencies. Vox Sang. 2008, 95, 137–148.
    • (2008) Vox Sang , vol.95 , pp. 137-148
    • Martin-Rendon, E.1    Sweeney, D.2    Lu, F.3    Girdlestone, J.4    Navarrete, C.5    Watt, S.M.6
  • 34
    • 0038030816 scopus 로고    scopus 로고
    • Growth and differentiation of rat bone marrow stromal cells: Does 5-azacytidine trigger their cardiomyogenic differentiation?
    • Liu, Y.; Song, J.; Liu, W.; Wan, Y.; Chen, X.; Hu, C. Growth and differentiation of rat bone marrow stromal cells: Does 5-azacytidine trigger their cardiomyogenic differentiation? Cardiovasc. Res. 2003, 58, 460–468.
    • (2003) Cardiovasc. Res. , vol.58 , pp. 460-468
    • Liu, Y.1    Song, J.2    Liu, W.3    Wan, Y.4    Chen, X.5    Hu, C.6
  • 35
    • 79955915974 scopus 로고    scopus 로고
    • Effect of 5-azacytidine: Evidence for alteration of the multipotent ability of mesenchymal stem cells
    • Rosca, A.M.; Burlacu, A. Effect of 5-azacytidine: Evidence for alteration of the multipotent ability of mesenchymal stem cells. Stem Cells Dev. 2011, 20, 1213–1221.
    • (2011) Stem Cells Dev , vol.20 , pp. 1213-1221
    • Rosca, A.M.1    Burlacu, A.2
  • 36
    • 84880646802 scopus 로고    scopus 로고
    • DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes
    • Naeem, N.; Haneef, K.; Kabir, N.; Iqbal, H.; Jamall, S.; Salim, A. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the transdifferentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes. Cardiovasc. Ther. 2013, 31, 201–209.
    • (2013) Cardiovasc. Ther. , vol.31 , pp. 201-209
    • Naeem, N.1    Haneef, K.2    Kabir, N.3    Iqbal, H.4    Jamall, S.5    Salim, A.6
  • 38
    • 80155126060 scopus 로고    scopus 로고
    • DNA methylation in stem cell renewal and multipotency
    • Berdasco, M.; Esteller, M. DNA methylation in stem cell renewal and multipotency. Stem Cell Res. Ther. 2011, 2, 42.
    • (2011) Stem Cell Res. Ther. , vol.2 , pp. 42
    • Berdasco, M.1    Esteller, M.2
  • 39
    • 79959883334 scopus 로고    scopus 로고
    • Role of Oct4 in maintaining and regaining stem cell pluripotency
    • Shi, G.; Jin, Y. Role of Oct4 in maintaining and regaining stem cell pluripotency. Stem Cell Res. Ther. 2010, 1, 39.
    • (2010) Stem Cell Res. Ther. , vol.1 , pp. 39
    • Shi, G.1    Jin, Y.2
  • 41
    • 38649126918 scopus 로고    scopus 로고
    • Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation
    • Fouse, S.D.; Shen, Y.; Pellegrini, M.; Cole, S.; Meissner, A.; Van Neste, L.; Jaenisch, R.; Fan, G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2008, 2, 160–169.
    • (2008) Cell Stem Cell , vol.2 , pp. 160-169
    • Fouse, S.D.1    Shen, Y.2    Pellegrini, M.3    Cole, S.4    Meissner, A.5    van Neste, L.6    Jaenisch, R.7    Fan, G.8
  • 42
    • 72949122798 scopus 로고    scopus 로고
    • Chromatin states of core pluripotency-associated genes in pluripotent, multipotent and differentiated cells
    • Barrand, S.; Collas, P. Chromatin states of core pluripotency-associated genes in pluripotent, multipotent and differentiated cells. Biochem. Biophys. Res. Commun. 2010, 391, 762–767.
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 762-767
    • Barrand, S.1    Collas, P.2
  • 43
    • 84969594630 scopus 로고    scopus 로고
    • Histone deacetylases and cardiovascular cell lineage commitment
    • Yang, J.Y.; Wang, Q.; Wang, W.; Zeng, L.F. Histone deacetylases and cardiovascular cell lineage commitment. World J. Stem Cells 2015, 7, 852–858.
    • (2015) World J. Stem Cells , vol.7 , pp. 852-858
    • Yang, J.Y.1    Wang, Q.2    Wang, W.3    Zeng, L.F.4
  • 45
    • 77952348698 scopus 로고    scopus 로고
    • Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation
    • Dovey, O.M.; Foster, C.T.; Cowley, S.M. Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc. Natl. Acad. Sci. USA 2010, 107, 8242–8247.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 8242-8247
    • Dovey, O.M.1    Foster, C.T.2    Cowley, S.M.3
  • 46
    • 84898670852 scopus 로고    scopus 로고
    • Downregulation of HDAC1 is involved in the cardiomyocyte differentiation from mesenchymal stem cells in a myocardial microenvironment
    • Lu, D.F.; Yao, Y.; Su, Z.Z.; Zeng, Z.H.; Xing, X.W.; He, Z.Y.; Zhang, C. Downregulation of HDAC1 is involved in the cardiomyocyte differentiation from mesenchymal stem cells in a myocardial microenvironment. PLoS ONE 2014, 9, e93222.
    • (2014) Plos ONE , vol.9
    • Lu, D.F.1    Yao, Y.2    Su, Z.Z.3    Zeng, Z.H.4    Xing, X.W.5    He, Z.Y.6    Zhang, C.7
  • 47
    • 84899847496 scopus 로고    scopus 로고
    • Knockdown of the HDAC1 promotes the directed differentiation of bone mesenchymal stem cells into cardiomyocytes
    • Lu, D.F.; Wang, Y.; Su, Z.Z.; Zeng, Z.H.; Xing, X.W.; He, Z.Y.; Zhang, C. Knockdown of the HDAC1 promotes the directed differentiation of bone mesenchymal stem cells into cardiomyocytes. PLoS ONE 2014, 9, e92179.
    • (2014) Plos ONE , vol.9
    • Lu, D.F.1    Wang, Y.2    Su, Z.Z.3    Zeng, Z.H.4    Xing, X.W.5    He, Z.Y.6    Zhang, C.7
  • 48
    • 58549098709 scopus 로고    scopus 로고
    • WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1
    • Liu, Z.; Li, T.; Liu, Y.; Jia, Z.; Li, Y.; Zhang, C.; Chen, P.; Ma, K.; Affara, N.; Zhou, C. WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1. Biochim. Biophys. Acta 2009, 1793, 300–311.
    • (2009) Biochim. Biophys. Acta , vol.1793 , pp. 300-311
    • Liu, Z.1    Li, T.2    Liu, Y.3    Jia, Z.4    Li, Y.5    Zhang, C.6    Chen, P.7    Ma, K.8    Affara, N.9    Zhou, C.10
  • 50
    • 84867905127 scopus 로고    scopus 로고
    • Histone deacetylase 1 deficiency impairs differentiation and electrophysiological properties of cardiomyocytes derived from induced pluripotent cells
    • Hoxha, E.; Lambers, E.; Xie, H.; De Andrade, A.; Krishnamurthy, P.; Wasserstrom, J.A.; Ramirez, V.; Thal, M.; Verma, S.K.; Soares, M.B.; et al. Histone deacetylase 1 deficiency impairs differentiation and electrophysiological properties of cardiomyocytes derived from induced pluripotent cells. Stem Cell. 2012, 30, 2412–2422.
    • (2012) Stem Cell , vol.30 , pp. 2412-2422
    • Hoxha, E.1    Lambers, E.2    Xie, H.3    de Andrade, A.4    Krishnamurthy, P.5    Wasserstrom, J.A.6    Ramirez, V.7    Thal, M.8    Verma, S.K.9    Soares, M.B.10
  • 51
    • 85018787862 scopus 로고    scopus 로고
    • Multi-omics approaches to disease
    • Hasin, Y.; Seldin, M.; Lusis, A. Multi-omics approaches to disease. Genome Biol. 2017, 18, 83.
    • (2017) Genome Biol , vol.18 , pp. 83
    • Hasin, Y.1    Seldin, M.2    Lusis, A.3
  • 54
    • 77952065242 scopus 로고    scopus 로고
    • Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities
    • Medina, R.J.; O’Neill, C.L.; Sweeney, M.; Guduric-Fuchs, J.; Gardiner, T.A.; Simpson, D.A.; Stitt, A.W. Molecular analysis of endothelial progenitor cell (EPC) subtypes reveals two distinct cell populations with different identities. BMC Med. Genom. 2010, 3, 18.
    • (2010) BMC Med. Genom. , vol.3 , pp. 18
    • Medina, R.J.1    O’Neill, C.L.2    Sweeney, M.3    Guduric-Fuchs, J.4    Gardiner, T.A.5    Simpson, D.A.6    Stitt, A.W.7
  • 55
    • 84978794972 scopus 로고    scopus 로고
    • Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges
    • Steinle, H.; Behring, A.; Schlensak, C.; Wendel, H.P.; Avci-Adali, M. Concise Review: Application of In Vitro Transcribed Messenger RNA for Cellular Engineering and Reprogramming: Progress and Challenges. Stem Cell. 2017, 35, 68–79.
    • (2017) Stem Cell , vol.35 , pp. 68-79
    • Steinle, H.1    Behring, A.2    Schlensak, C.3    Wendel, H.P.4    Avci-Adali, M.5
  • 57
    • 84880997880 scopus 로고    scopus 로고
    • MicroRNAs in stem cell function and regenerative therapy of the heart
    • Seeger, F.H.; Zeiher, A.M.; Dimmeler, S. MicroRNAs in stem cell function and regenerative therapy of the heart. Arterioscler. Thromb. Vasc. Biol. 2013, 33, 1739–1746.
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , pp. 1739-1746
    • Seeger, F.H.1    Zeiher, A.M.2    Dimmeler, S.3
  • 58
    • 84881353260 scopus 로고    scopus 로고
    • MicroRNA regulation and role in stem cell maintenance, cardiac differentiation and hypertrophy
    • Kuppusamy, K.T.; Sperber, H.; Ruohola-Baker, H. MicroRNA regulation and role in stem cell maintenance, cardiac differentiation and hypertrophy. Curr. Mol. Med. 2013, 13, 757–764.
    • (2013) Curr. Mol. Med. , vol.13 , pp. 757-764
    • Kuppusamy, K.T.1    Sperber, H.2    Ruohola-Baker, H.3
  • 59
    • 84899005497 scopus 로고    scopus 로고
    • Concise review: MicroRNAs as modulators of stem cells and angiogenesis
    • Kane, N.M.; Thrasher, A.J.; Angelini, G.D.; Emanueli, C. Concise review: MicroRNAs as modulators of stem cells and angiogenesis. Stem Cell. 2014, 32, 1059–1066.
    • (2014) Stem Cell , vol.32 , pp. 1059-1066
    • Kane, N.M.1    Thrasher, A.J.2    Angelini, G.D.3    Emanueli, C.4
  • 60
    • 85117875301 scopus 로고    scopus 로고
    • MicroRNAs and cardiac stem cells in heart development and disease
    • in press
    • Li, B.; Meng, X.; Zhang, L. microRNAs and cardiac stem cells in heart development and disease. Drug Discov. Today. 2018 (in press)
    • (2018) Drug Discov. Today.
    • Li, B.1    Meng, X.2    Zhang, L.3
  • 61
    • 84994252323 scopus 로고    scopus 로고
    • Stem Cell-Derived Exosomes, Autophagy, Extracellular Matrix Turnover, and miRNAs in Cardiac Regeneration during Stem Cell Therapy
    • Prathipati, P.; Nandi, S.S.; Mishra, P.K. Stem Cell-Derived Exosomes, Autophagy, Extracellular Matrix Turnover, and miRNAs in Cardiac Regeneration during Stem Cell Therapy. Stem Cell Rev. 2017, 13, 79–91.
    • (2017) Stem Cell Rev , vol.13 , pp. 79-91
    • Prathipati, P.1    Nandi, S.S.2    Mishra, P.K.3
  • 63
    • 84871322435 scopus 로고    scopus 로고
    • Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: Role for impaired in vivo neovascularization and cardiac repair capacity
    • Jakob, P.; Doerries, C.; Briand, S.; Mocharla, P.; Krankel, N.; Besler, C.; Mueller, M.; Manes, C.; Templin, C.; Baltes, C.; et al. Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: Role for impaired in vivo neovascularization and cardiac repair capacity. Circulation 2012, 126, 2962–2975.
    • (2012) Circulation , vol.126 , pp. 2962-2975
    • Jakob, P.1    Doerries, C.2    Briand, S.3    Mocharla, P.4    Krankel, N.5    Besler, C.6    Mueller, M.7    Manes, C.8    Templin, C.9    Baltes, C.10
  • 64
    • 82455162808 scopus 로고    scopus 로고
    • Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway
    • Chen, J.J.; Zhou, S.H. Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway. Cardiol. J. 2011, 18, 675–681.
    • (2011) Cardiol. J. , vol.18 , pp. 675-681
    • Chen, J.J.1    Zhou, S.H.2
  • 65
    • 84873163360 scopus 로고    scopus 로고
    • Mesenchymal stem cells modified with miR-126 release angiogenic factors and activate Notch ligand Delta-like-4, enhancing ischemic angiogenesis and cell survival
    • Huang, F.; Zhu, X.; Hu, X.Q.; Fang, Z.F.; Tang, L.; Lu, X.L.; Zhou, S.H. Mesenchymal stem cells modified with miR-126 release angiogenic factors and activate Notch ligand Delta-like-4, enhancing ischemic angiogenesis and cell survival. Int. J. Mol. Med. 2013, 31, 484–492.
    • (2013) Int. J. Mol. Med. , vol.31 , pp. 484-492
    • Huang, F.1    Zhu, X.2    Hu, X.Q.3    Fang, Z.F.4    Tang, L.5    Lu, X.L.6    Zhou, S.H.7
  • 67
    • 80052712758 scopus 로고    scopus 로고
    • Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation
    • Hu, S.; Huang, M.; Nguyen, P.K.; Gong, Y.; Li, Z.; Jia, F.; Lan, F.; Liu, J.; Nag, D.; Robbins, R.C.; et al. Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation. Circulation 2011, 124 (Suppl. 11), S27–S34.
    • (2011) Circulation , vol.124 , pp. S27-S34
    • Hu, S.1    Huang, M.2    Nguyen, P.K.3    Gong, Y.4    Li, Z.5    Jia, F.6    Lan, F.7    Liu, J.8    Nag, D.9    Robbins, R.C.10
  • 68
    • 85048550511 scopus 로고    scopus 로고
    • The roles of non-coding RNAs in cardiac regenerative medicine
    • Choong, O.K.; Lee, D.S.; Chen, C.Y.; Hsieh, P.C. The roles of non-coding RNAs in cardiac regenerative medicine. Non-Coding RNA Res. 2017, 2, 100–110.
    • (2017) Non-Coding RNA Res , vol.2 , pp. 100-110
    • Choong, O.K.1    Lee, D.S.2    Chen, C.Y.3    Hsieh, P.C.4
  • 71
    • 80355128968 scopus 로고    scopus 로고
    • MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart
    • Glass, C.; Singla, D.K. MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart. Am. J. Physiol. Heart Circ. Physiol. 2011, 301, H2038–H2049.
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.301 , pp. H2038-H2049
    • Glass, C.1    Singla, D.K.2
  • 77
    • 84902141800 scopus 로고    scopus 로고
    • Long noncoding RNAs in cell-fate programming and reprogramming
    • Flynn, R.A.; Chang, H.Y. Long noncoding RNAs in cell-fate programming and reprogramming. Cell Stem Cell 2014, 14, 752–761.
    • (2014) Cell Stem Cell , vol.14 , pp. 752-761
    • Flynn, R.A.1    Chang, H.Y.2
  • 82
    • 85042184378 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis
    • Shi, B.; Wang, Y.; Zhao, R.; Long, X.; Deng, W.; Wang, Z. Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis. PLoS ONE 2018, 13, e0191616.
    • (2018) Plos ONE , vol.13
    • Shi, B.1    Wang, Y.2    Zhao, R.3    Long, X.4    Deng, W.5    Wang, Z.6
  • 84
    • 84897808834 scopus 로고    scopus 로고
    • Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22
    • Feng, Y.; Huang, W.; Wani, M.; Yu, X.; Ashraf, M. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS ONE 2014, 9, e88685.
    • (2014) Plos ONE , vol.9
    • Feng, Y.1    Huang, W.2    Wani, M.3    Yu, X.4    Ashraf, M.5
  • 85
    • 85022226203 scopus 로고    scopus 로고
    • Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis
    • Gong, M.; Yu, B.; Wang, J.; Wang, Y.; Liu, M.; Paul, C.; Millard, R.W.; Xiao, D.S.; Ashraf, M.; Xu, M. Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis. Oncotarget 2017, 8, 45200–45212.
    • (2017) Oncotarget , vol.8 , pp. 45200-45212
    • Gong, M.1    Yu, B.2    Wang, J.3    Wang, Y.4    Liu, M.5    Paul, C.6    Millard, R.W.7    Xiao, D.S.8    Ashraf, M.9    Xu, M.10
  • 87
    • 84899980641 scopus 로고    scopus 로고
    • Exosomes as critical agents of cardiac regeneration triggered by cell therapy
    • Ibrahim, A.G.; Cheng, K.; Marban, E. Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Rep. 2014, 2, 606–619.
    • (2014) Stem Cell Rep , vol.2 , pp. 606-619
    • Ibrahim, A.G.1    Cheng, K.2    Marban, E.3
  • 88
  • 89
    • 85020193540 scopus 로고    scopus 로고
    • MiR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit(+) cells to promote proliferation and inhibit apoptosis through a negative feedback loop
    • Liu, J.; Wang, Y.; Cui, J.; Sun, M.; Pu, Z.; Wang, C.; Du, W.; Liu, X.; Wu, J.; Hou, J. et al. miR199a-3p regulates P53 by targeting CABLES1 in mouse cardiac c-kit(+) cells to promote proliferation and inhibit apoptosis through a negative feedback loop. Stem Cell Res. Ther. 2017, 8, 127.
    • (2017) Stem Cell Res. Ther. , vol.8 , pp. 127
    • Liu, J.1    Wang, Y.2    Cui, J.3    Sun, M.4    Pu, Z.5    Wang, C.6    Du, W.7    Liu, X.8    Wu, J.9    Hou, J.10
  • 90
    • 84919807883 scopus 로고    scopus 로고
    • MiR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18
    • Lee, S.; Yu, K.R.; Ryu, Y.S.; Oh, Y.S.; Hong, I.S.; Kim, H.S.; Lee, J.Y.; Kim, S.; Seo, K.W.; Kang, K.S. miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18. Age 2014, 36, 9724.
    • (2014) Age , vol.36 , pp. 9724
    • Lee, S.1    Yu, K.R.2    Ryu, Y.S.3    Oh, Y.S.4    Hong, I.S.5    Kim, H.S.6    Lee, J.Y.7    Kim, S.8    Seo, K.W.9    Kang, K.S.10
  • 91
    • 70450240736 scopus 로고    scopus 로고
    • Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2
    • Kim, H.W.; Haider, H.K.; Jiang, S.; Ashraf, M. Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J. Biol. Chem. 2009, 284, 33161–33168.
    • (2009) J. Biol. Chem. , vol.284 , pp. 33161-33168
    • Kim, H.W.1    Haider, H.K.2    Jiang, S.3    Ashraf, M.4
  • 93
    • 67650474075 scopus 로고    scopus 로고
    • Role of specific microRNAs for endothelial function and angiogenesis
    • Wu, F.; Yang, Z.; Li, G. Role of specific microRNAs for endothelial function and angiogenesis. Biochem Biophys. Res. Commun. 2009, 386, 549–553.
    • (2009) Biochem Biophys. Res. Commun. , vol.386 , pp. 549-553
    • Wu, F.1    Yang, Z.2    Li, G.3
  • 94
    • 85009789310 scopus 로고    scopus 로고
    • Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro
    • Hou, J.; Long, H.; Zhou, C.; Zheng, S.; Wu, H.; Guo, T.; Wu, Q., Zhong, T.; Wang, T. Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro. Stem Cell Res. Ther. 2017, 8, 4.
    • (2017) Stem Cell Res. Ther. , vol.8 , pp. 4
    • Hou, J.1    Long, H.2    Zhou, C.3    Zheng, S.4    Wu, H.5    Guo, T.6    Wu, Q.7    Zhong, T.8    Wang, T.9
  • 95
    • 84876367541 scopus 로고    scopus 로고
    • Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal
    • Wang, Y.; Xu, Z.; Jiang, J.; Xu, C.; Kang, J.; Xiao, L.; Wu, M.; Xiong, J.; Guo, X., Liu, H. Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. Dev. Cell. 2013, 25, 69–80.
    • (2013) Dev. Cell. , vol.25 , pp. 69-80
    • Wang, Y.1    Xu, Z.2    Jiang, J.3    Xu, C.4    Kang, J.5    Xiao, L.6    Wu, M.7    Xiong, J.8    Guo, X.9    Liu, H.10
  • 96
    • 84930614073 scopus 로고    scopus 로고
    • Systems-based technologies in profiling the stem cell molecular framework for cardioregenerative medicine
    • Wyles, S.P.; Faustino, R.S.; Li, X.; Terzic, A.; Nelson, T.J. Systems-based technologies in profiling the stem cell molecular framework for cardioregenerative medicine. Stem Cell Rev. 2015, 11, 501–510.
    • (2015) Stem Cell Rev , vol.11 , pp. 501-510
    • Wyles, S.P.1    Faustino, R.S.2    Li, X.3    Terzic, A.4    Nelson, T.J.5
  • 97
    • 1542327692 scopus 로고    scopus 로고
    • Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling
    • Prudhomme, W.; Daley, G.Q.; Zandstra, P.; Lauffenburger, D.A. Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling. Proc. Natl. Acad. Sci. USA 2004, 101, 2900– 2905.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2900-2905
    • Prudhomme, W.1    Daley, G.Q.2    Zandstra, P.3    Lauffenburger, D.A.4
  • 101
    • 84956555171 scopus 로고    scopus 로고
    • Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications
    • Tao, Z.H.; Han, Z.C.; Li, Z. Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications. Stem Cell. Int. 2016, doi:10.1155/2016/1314709.
    • (2016) Stem Cell. Int.
    • Tao, Z.H.1    Han, Z.C.2    Li, Z.3
  • 102
    • 85048851384 scopus 로고    scopus 로고
    • Mesenchymal Stem Cell Paracrine Factors in Vascular Repair and Regeneration
    • Pankajakshan, D.; Agrawal, D.K. Mesenchymal Stem Cell Paracrine Factors in Vascular Repair and Regeneration. J. Biomed. Technol. Res. 2014, 1, doi: 10.19104/jbtr.2014.107.
    • (2014) J. Biomed. Technol. Res. , vol.1
    • Pankajakshan, D.1    Agrawal, D.K.2
  • 104
    • 85034953369 scopus 로고    scopus 로고
    • VEGF secreted by mesenchymal stem cells mediates the differentiation of endothelial progenitor cells into endothelial cells via paracrine mechanisms
    • Ge, Q.; Zhang, H.; Hou, J.; Wan, L.; Cheng, W.; Wang, X.; Dong, D.; Chen, C.; Xia, J.; Guo, J.; et al. VEGF secreted by mesenchymal stem cells mediates the differentiation of endothelial progenitor cells into endothelial cells via paracrine mechanisms. Mol. Med. Rep. 2018, 17, 1667–1675.
    • (2018) Mol. Med. Rep. , vol.17 , pp. 1667-1675
    • Ge, Q.1    Zhang, H.2    Hou, J.3    Wan, L.4    Cheng, W.5    Wang, X.6    Dong, D.7    Chen, C.8    Xia, J.9    Guo, J.10
  • 105
    • 67249152019 scopus 로고    scopus 로고
    • Cardiac stem/progenitor cells, secreted proteins, and proteomics
    • Stastna, M.; Abraham, M.R.; Van Eyk, J.E. Cardiac stem/progenitor cells, secreted proteins, and proteomics. FEBS Lett. 2009, 583, 1800–1807.
    • (2009) FEBS Lett , vol.583 , pp. 1800-1807
    • Stastna, M.1    Abraham, M.R.2    van Eyk, J.E.3
  • 107
    • 26844525184 scopus 로고    scopus 로고
    • Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells
    • Urbich, C.; Aicher, A.; Heeschen, C.; Dernbach, E.; Hofmann, W.K.; Zeiher, A.M.; Dimmeler, S. Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J. Mol. Cell Cardiol. 2005, 39, 733–742.
    • (2005) J. Mol. Cell Cardiol. , vol.39 , pp. 733-742
    • Urbich, C.1    Aicher, A.2    Heeschen, C.3    Dernbach, E.4    Hofmann, W.K.5    Zeiher, A.M.6    Dimmeler, S.7
  • 108
    • 84878722569 scopus 로고    scopus 로고
    • Cardiopoietic stem cell therapy in heart failure: The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics
    • Bartunek, J.; Behfar, A.; Dolatabadi, D.; Vanderheyden, M.; Ostojic, M.; Dens, J.; El Nakadi, B.; Banovic, M.; Beleslin, B.; Vrolix, M.; et al. Cardiopoietic stem cell therapy in heart failure: The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J. Am. Coll Cardiol. 2013, 61, 2329–2338.
    • (2013) J. Am. Coll Cardiol. , vol.61 , pp. 2329-2338
    • Bartunek, J.1    Behfar, A.2    Dolatabadi, D.3    Vanderheyden, M.4    Ostojic, M.5    Dens, J.6    El Nakadi, B.7    Banovic, M.8    Beleslin, B.9    Vrolix, M.10
  • 109
    • 85016214953 scopus 로고    scopus 로고
    • Cardiopoietic cell therapy for advanced ischaemic heart failure: Results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial
    • Bartunek, J.; Terzic, A.; Davison, B.A.; Filippatos, G.S.; Radovanovic, S.; Beleslin, B.; Merkely, B.; Musialek, P.; Wojakowski, W.; Andreka, P. et al. Cardiopoietic cell therapy for advanced ischaemic heart failure: Results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial. Eur. Heart J. 2017, 38, 648–660.
    • (2017) Eur. Heart J. , vol.38 , pp. 648-660
    • Bartunek, J.1    Terzic, A.2    Davison, B.A.3    Filippatos, G.S.4    Radovanovic, S.5    Beleslin, B.6    Merkely, B.7    Musialek, P.8    Wojakowski, W.9    Andreka, P.10
  • 110
    • 84941313402 scopus 로고    scopus 로고
    • Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: The STOP-HF randomized Phase II trial
    • Chung, E.S.; Miller, L.; Patel, A.N.; Anderson, R.D.; Mendelsohn, F.O.; Traverse, J.; Silver, K.H.; Shin, J.; Ewald, G.; Farr, M.J. et al. Changes in ventricular remodelling and clinical status during the year following a single administration of stromal cell-derived factor-1 non-viral gene therapy in chronic ischaemic heart failure patients: The STOP-HF randomized Phase II trial. Eur. Heart J. 2015, 36, 2228–2238.
    • (2015) Eur. Heart J. , vol.36 , pp. 2228-2238
    • Chung, E.S.1    Miller, L.2    Patel, A.N.3    Anderson, R.D.4    Mendelsohn, F.O.5    Traverse, J.6    Silver, K.H.7    Shin, J.8    Ewald, G.9    Farr, M.J.10
  • 113
    • 84949293824 scopus 로고    scopus 로고
    • How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?
    • Li, L.; Chen, X.; Wang, W.E.; Zeng, C. How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart? Stem Cell. Int. 2016, 2016, 9682757.
    • (2016) Stem Cell. Int. , vol.2016
    • Li, L.1    Chen, X.2    Wang, W.E.3    Zeng, C.4
  • 114
    • 85030165876 scopus 로고    scopus 로고
    • Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology
    • Der Sarkissian, S.; Levesque, T.; Noiseux, N. Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology. World J. Stem Cell. 2017, 9, 9–25.
    • (2017) World J. Stem Cell. , vol.9 , pp. 9-25
    • der Sarkissian, S.1    Levesque, T.2    Noiseux, N.3
  • 116
    • 33750084372 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expressing mesenchymal stem cells improves cardiac function in chronic myocardial infarction in pigs
    • Yi, F.; Guo, W.Y.; Lu, A.L.; Wang, H.C.; Li, H.; Li, W.J.; Liu, B.; Zhang, D.X.; Luan, R.H.; Cheng, H.X.; et al. Vascular endothelial growth factor expressing mesenchymal stem cells improves cardiac function in chronic myocardial infarction in pigs. Chin. Med. J. 2006, 119, 1664–1668.
    • (2006) Chin. Med. J. , vol.119 , pp. 1664-1668
    • Yi, F.1    Guo, W.Y.2    Lu, A.L.3    Wang, H.C.4    Li, H.5    Li, W.J.6    Liu, B.7    Zhang, D.X.8    Luan, R.H.9    Cheng, H.X.10
  • 117
    • 0141796313 scopus 로고    scopus 로고
    • Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
    • Mangi, A.A.; Noiseux, N.; Kong, D.; He, H.; Rezvani, M.; Ingwall, J.S.; Dzau, V.J. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat. Med. 2003, 9, 1195– 1201.
    • (2003) Nat. Med. , vol.9 , pp. 1195-1201
    • Mangi, A.A.1    Noiseux, N.2    Kong, D.3    He, H.4    Rezvani, M.5    Ingwall, J.S.6    Dzau, V.J.7
  • 118
    • 33751038565 scopus 로고    scopus 로고
    • Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
    • Noiseux, N.; Gnecchi, M.; Lopez-Ilasaca, M.; Zhang, L.; Solomon, S.D.; Deb, A.; Dzau, V.J.; Pratt, R.E. Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation. Mol. Ther. J. Am. Soc. Gene Ther. 2006, 14, 840–850.
    • (2006) Mol. Ther. J. Am. Soc. Gene Ther. , vol.14 , pp. 840-850
    • Noiseux, N.1    Gnecchi, M.2    Lopez-Ilasaca, M.3    Zhang, L.4    Solomon, S.D.5    Deb, A.6    Dzau, V.J.7    Pratt, R.E.8
  • 119
    • 33646252939 scopus 로고    scopus 로고
    • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
    • Gnecchi, M.; He, H.; Noiseux, N.; Liang, O.D.; Zhang, L.; Morello, F.; Mu, H.; Melo, L.G.; Pratt, R.E.; Ingwall, J.S.; et al. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. 2006, 20, 661–669.
    • (2006) FASEB J , vol.20 , pp. 661-669
    • Gnecchi, M.1    He, H.2    Noiseux, N.3    Liang, O.D.4    Zhang, L.5    Morello, F.6    Mu, H.7    Melo, L.G.8    Pratt, R.E.9    Ingwall, J.S.10
  • 120
    • 33749334628 scopus 로고    scopus 로고
    • Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair
    • Jiang, S.; Haider, H.; Idris, N.M.; Salim, A.; Ashraf, M. Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair. Circ. Res. 2006, 99, 776–784.
    • (2006) Circ. Res. , vol.99 , pp. 776-784
    • Jiang, S.1    Haider, H.2    Idris, N.M.3    Salim, A.4    Ashraf, M.5
  • 121
    • 84963863990 scopus 로고    scopus 로고
    • Kallikrein-kinin in stem cell therapy
    • Chao, J.; Bledsoe, G.; Chao, L. Kallikrein-kinin in stem cell therapy. World J. Stem Cells 2014, 6, 448–457.
    • (2014) World J. Stem Cells , vol.6 , pp. 448-457
    • Chao, J.1    Bledsoe, G.2    Chao, L.3
  • 123
    • 37549065155 scopus 로고    scopus 로고
    • Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion
    • Yin, H.; Chao, L.; Chao, J. Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion. Life Sci. 2008, 82, 156–165.
    • (2008) Life Sci , vol.82 , pp. 156-165
    • Yin, H.1    Chao, L.2    Chao, J.3
  • 124
    • 37549013723 scopus 로고    scopus 로고
    • New perspective on the tissue kallikrein-kinin system in myocardial infarction: Role of angiogenesis and cardiac regeneration
    • Westermann, D.; Schultheiss, H.P.; Tschope, C. New perspective on the tissue kallikrein-kinin system in myocardial infarction: Role of angiogenesis and cardiac regeneration. Int. Immunopharmacol. 2008, 8, 148– 154.
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 148-154
    • Westermann, D.1    Schultheiss, H.P.2    Tschope, C.3
  • 125
    • 56549100971 scopus 로고    scopus 로고
    • Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway
    • Yao, Y.Y.; Yin, H.; Shen, B.; Smith, R.S., Jr.; Liu, Y.; Gao, L.; Chao, L.; Chao, J. Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway. Cardiovasc. Res. 2008, 80, 354–364.
    • (2008) Cardiovasc. Res. , vol.80 , pp. 354-364
    • Yao, Y.Y.1    Yin, H.2    Shen, B.3    Smith, R.S.4    Liu, Y.5    Gao, L.6    Chao, L.7    Chao, J.8
  • 126
    • 14844321901 scopus 로고    scopus 로고
    • Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways
    • Yin, H.; Chao, L.; Chao, J. Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways. J. Biol. Chem. 2005, 280, 8022– 8030.
    • (2005) J. Biol. Chem. , vol.280 , pp. 8022-8030
    • Yin, H.1    Chao, L.2    Chao, J.3
  • 127
    • 0022083410 scopus 로고
    • Cerebrospinal fluid cytopathology
    • Schumann, G.B.; Crisman, L.G. Cerebrospinal fluid cytopathology. Clin. Lab. Med. 1985, 5, 275–302.
    • (1985) Clin. Lab. Med. , vol.5 , pp. 275-302
    • Schumann, G.B.1    Crisman, L.G.2
  • 129
    • 84880843626 scopus 로고    scopus 로고
    • Tissue kallikrein-modified mesenchymal stem cells provide enhanced protection against ischemic cardiac injury after myocardial infarction
    • Gao, L.; Bledsoe, G.; Yin, H.; Shen, B.; Chao, L.; Chao, J. Tissue kallikrein-modified mesenchymal stem cells provide enhanced protection against ischemic cardiac injury after myocardial infarction. Circ. J. 2013, 77, 2134–2144.
    • (2013) Circ. J. , vol.77 , pp. 2134-2144
    • Gao, L.1    Bledsoe, G.2    Yin, H.3    Shen, B.4    Chao, L.5    Chao, J.6
  • 131
    • 27244456956 scopus 로고    scopus 로고
    • Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions
    • Song, H.; Kwon, K.; Lim, S.; Kang, S.M.; Ko, Y.G.; Xu, Z.; Chung, J.H.; Kim, B.S.; Lee, H.; Joung, B.; et al. Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions. Mol. Cell. 2005, 19, 402–407.
    • (2005) Mol. Cell. , vol.19 , pp. 402-407
    • Song, H.1    Kwon, K.2    Lim, S.3    Kang, S.M.4    Ko, Y.G.5    Xu, Z.6    Chung, J.H.7    Kim, B.S.8    Lee, H.9    Joung, B.10
  • 132
    • 58149345104 scopus 로고    scopus 로고
    • IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair
    • Haider, H.; Jiang, S.; Idris, N.M.; Ashraf, M. IGF-1-overexpressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1alpha/CXCR4 signaling to promote myocardial repair. Circ. Res. 2008, 103, 1300–1308.
    • (2008) Circ. Res. , vol.103 , pp. 1300-1308
    • Haider, H.1    Jiang, S.2    Idris, N.M.3    Ashraf, M.4
  • 133
    • 67649628227 scopus 로고    scopus 로고
    • Integrin-linked kinase is required in hypoxic mesenchymal stem cells for strengthening cell adhesion to ischemic myocardium
    • Song, S.W.; Chang, W.; Song, B.W.; Song, H.; Lim, S.; Kim, H.J.; Cha, M.J.; Choi, E.; Im, S.H.; Chang, B.C.; et al. Integrin-linked kinase is required in hypoxic mesenchymal stem cells for strengthening cell adhesion to ischemic myocardium. Stem Cell. 2009, 27, 1358–1365.
    • (2009) Stem Cell , vol.27 , pp. 1358-1365
    • Song, S.W.1    Chang, W.2    Song, B.W.3    Song, H.4    Lim, S.5    Kim, H.J.6    Cha, M.J.7    Choi, E.8    Im, S.H.9    Chang, B.C.10
  • 134
    • 77953537513 scopus 로고    scopus 로고
    • Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction
    • Tang, J.; Wang, J.; Guo, L.; Kong, X.; Yang, J.; Zheng, F.; Zhang, L.; Huang, Y.; et al. Mesenchymal stem cells modified with stromal cell-derived factor 1 alpha improve cardiac remodeling via paracrine activation of hepatocyte growth factor in a rat model of myocardial infarction. Mol. Cell. 2010, 29, 9–19.
    • (2010) Mol. Cell. , vol.29 , pp. 9-19
    • Tang, J.1    Wang, J.2    Guo, L.3    Kong, X.4    Yang, J.5    Zheng, F.6    Zhang, L.7    Huang, Y.8
  • 135
    • 77954948113 scopus 로고    scopus 로고
    • Enhancement of the survival of engrafted mesenchymal stem cells in the ischemic heart by TNFR gene transfection. Biochemistry and cell biology
    • Bao, C.; Guo, J.; Zheng, M.; Chen, Y.; Lin, G.; Hu, M. Enhancement of the survival of engrafted mesenchymal stem cells in the ischemic heart by TNFR gene transfection. Biochemistry and cell biology. Biochem. Cell Biol. 2010, 88, 629–634.
    • (2010) Biochem. Cell Biol. , vol.88 , pp. 629-634
    • Bao, C.1    Guo, J.2    Zheng, M.3    Chen, Y.4    Lin, G.5    Hu, M.6
  • 136
    • 27744505661 scopus 로고    scopus 로고
    • Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector
    • Tang, Y.L.; Tang, Y.; Zhang, Y.C.; Qian, K.; Shen, L.; Phillips, M.I. Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J. Am. Coll. Cardiol. 2005, 46, 1339–1350.
    • (2005) J. Am. Coll. Cardiol. , vol.46 , pp. 1339-1350
    • Tang, Y.L.1    Tang, Y.2    Zhang, Y.C.3    Qian, K.4    Shen, L.5    Phillips, M.I.6
  • 137
    • 84865259847 scopus 로고    scopus 로고
    • Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity
    • Yao, Y.; Sheng, Z.; Li, Y.; Yan, F.; Fu, C.; Li, Y.; Ma, G.; Liu, N.; Chao, J.; Chao, L. Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity. Hum. Gene Ther. 2012, 23, 859–870.
    • (2012) Hum. Gene Ther. , vol.23 , pp. 859-870
    • Yao, Y.1    Sheng, Z.2    Li, Y.3    Yan, F.4    Fu, C.5    Li, Y.6    Ma, G.7    Liu, N.8    Chao, J.9    Chao, L.10
  • 138
    • 84877250260 scopus 로고    scopus 로고
    • Tissue kallikrein-modified human endothelial progenitor cell implantation improves cardiac function via enhanced activation of akt and increased angiogenesis
    • Yao, Y.; Sheng, Z.; Li, Y.; Fu, C.; Ma, G.; Liu, N.; Chao, J.; Chao, L. Tissue kallikrein-modified human endothelial progenitor cell implantation improves cardiac function via enhanced activation of akt and increased angiogenesis. Lab. Investig. 2013, 93, 577–591.
    • (2013) Lab. Investig. , vol.93 , pp. 577-591
    • Yao, Y.1    Sheng, Z.2    Li, Y.3    Fu, C.4    Ma, G.5    Liu, N.6    Chao, J.7    Chao, L.8
  • 139
    • 77958108352 scopus 로고    scopus 로고
    • Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction
    • Sen, S.; Merchan, J.; Dean, J.; Ii, M.; Gavin, M.; Silver, M.; Tkebuchava, T.; Yoon, Y.S.; Rasko, J.E.; Aikawa, R. Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction. Hum. Gene Ther. 2010, 21, 1327–1334.
    • (2010) Hum. Gene Ther. , vol.21 , pp. 1327-1334
    • Sen, S.1    Merchan, J.2    Dean, J.3    Ii, M.4    Gavin, M.5    Silver, M.6    Tkebuchava, T.7    Yoon, Y.S.8    Rasko, J.E.9    Aikawa, R.10
  • 141
    • 84911457666 scopus 로고    scopus 로고
    • The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult
    • Nadal-Ginard, B.; Ellison, G.M.; Torella, D. The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult. Stem Cell Res. 2014, 13, 615–630.
    • (2014) Stem Cell Res , vol.13 , pp. 615-630
    • Nadal-Ginard, B.1    Ellison, G.M.2    Torella, D.3
  • 151
    • 85006132780 scopus 로고    scopus 로고
    • Advances in Applications of Metabolomics in Pluripotent Stem Cell Research
    • Bhute, V.J.; Bao, X.; Palecek, S.P. Advances in Applications of Metabolomics in Pluripotent Stem Cell Research. Curr. Opin. Chem. Eng. 2017, 15, 36–43.
    • (2017) Curr. Opin. Chem. Eng. , vol.15 , pp. 36-43
    • Bhute, V.J.1    Bao, X.2    Palecek, S.P.3
  • 152
    • 16344380951 scopus 로고    scopus 로고
    • Low O2 tensions and the prevention of differentiation of hES cells
    • Ezashi, T.; Das, P.; Roberts, R.M. Low O2 tensions and the prevention of differentiation of hES cells. Proc. Natl. Acad. Sci. USA 2005, 102, 4783–4788.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 4783-4788
    • Ezashi, T.1    Das, P.2    Roberts, R.M.3
  • 153
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: A critical component of the stem cell niche
    • Mohyeldin, A.; Garzon-Muvdi, T.; Quinones-Hinojosa, A. Oxygen in stem cell biology: A critical component of the stem cell niche. Cell Stem Cell 2010, 7, 150–161.
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzon-Muvdi, T.2    Quinones-Hinojosa, A.3
  • 154
    • 33747875396 scopus 로고    scopus 로고
    • Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells
    • Cho, Y.M.; Kwon, S.; Pak, Y.K.; Seol, H.W.; Choi, Y.M.; Park, D.J.; Park, K.S.; Lee, H.K. Dynamic changes in mitochondrial biogenesis and antioxidant enzymes during the spontaneous differentiation of human embryonic stem cells. Biochem. Biophys. Res. Commun. 2006, 348, 1472–1478.
    • (2006) Biochem. Biophys. Res. Commun. , vol.348 , pp. 1472-1478
    • Cho, Y.M.1    Kwon, S.2    Pak, Y.K.3    Seol, H.W.4    Choi, Y.M.5    Park, D.J.6    Park, K.S.7    Lee, H.K.8
  • 155
  • 156
    • 84928203185 scopus 로고    scopus 로고
    • Metabolic regulation of mesenchymal stem cell in expansion and therapeutic application
    • Liu, Y.; Ma, T. Metabolic regulation of mesenchymal stem cell in expansion and therapeutic application. Biotechnol. Prog. 2015, 31, 468–481.
    • (2015) Biotechnol. Prog. , vol.31 , pp. 468-481
    • Liu, Y.1    Ma, T.2
  • 157
    • 84868351585 scopus 로고    scopus 로고
    • Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal
    • Zhang, J.; Nuebel, E.; Daley, G.Q.; Koehler, C.M.; Teitell, M.A. Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell 2012, 11, 589–595.
    • (2012) Cell Stem Cell , vol.11 , pp. 589-595
    • Zhang, J.1    Nuebel, E.2    Daley, G.Q.3    Koehler, C.M.4    Teitell, M.A.5
  • 160
    • 85030632102 scopus 로고    scopus 로고
    • Extracellular Microvesicles as Game Changers in Better Understanding the Complexity of Cellular Interactions-From Bench to Clinical Applications
    • Ratajczak, M.Z.; Ratajczak, J. Extracellular Microvesicles as Game Changers in Better Understanding the Complexity of Cellular Interactions-From Bench to Clinical Applications. Am. J. Med. Sci. 2017, 354, 449– 452.
    • (2017) Am. J. Med. Sci. , vol.354 , pp. 449-452
    • Ratajczak, M.Z.1    Ratajczak, J.2
  • 161
    • 84906089273 scopus 로고    scopus 로고
    • Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers
    • Li, M.; Zeringer, E.; Barta, T.; Schageman, J.; Cheng, A.; Vlassov, A.V. Analysis of the RNA content of the exosomes derived from blood serum and urine and its potential as biomarkers. Phil. Trans. R. Soc. B 2014, 369, 20130502.
    • (2014) Phil. Trans. R. Soc. B , vol.369 , pp. 20130502
    • Li, M.1    Zeringer, E.2    Barta, T.3    Schageman, J.4    Cheng, A.5    Vlassov, A.V.6
  • 163
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • Arslan, F.; Lai, R.C.; Smeets, M.B.; Akeroyd, L.; Choo, A.; Aguor, E.N.; Timmers, L.; van Rijen, H.V.; Doevendans, P.A.; Pasterkamp, G.; et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res. 2013, 10, 301–312.
    • (2013) Stem Cell Res , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3    Akeroyd, L.4    Choo, A.5    Aguor, E.N.6    Timmers, L.7    van Rijen, H.V.8    Doevendans, P.A.9    Pasterkamp, G.10
  • 164
    • 85047402267 scopus 로고    scopus 로고
    • Exosomes in Myocardial Repair: Advances and Challenges in the Development of Next-Generation Therapeutics
    • Adamiak, M.; Sahoo, S. Exosomes in Myocardial Repair: Advances and Challenges in the Development of Next-Generation Therapeutics. Mol. Ther. J. Am. Soc. Gene Ther. 2018, 26, 1635–1643.
    • (2018) Mol. Ther. J. Am. Soc. Gene Ther. , vol.26 , pp. 1635-1643
    • Adamiak, M.1    Sahoo, S.2
  • 165
    • 85033797972 scopus 로고    scopus 로고
    • Exosomes and cardioprotection—A critical analysis
    • Davidson, S.M.; Yellon, D.M. Exosomes and cardioprotection—A critical analysis. Mol. Asp. Med. 2018, 60, 104–114.
    • (2018) Mol. Asp. Med. , vol.60 , pp. 104-114
    • Davidson, S.M.1    Yellon, D.M.2
  • 166
    • 85048024676 scopus 로고    scopus 로고
    • Examining the Paracrine Effects of Exosomes in Cardiovascular Disease and Repair
    • Gartz, M.; Strande, J.L. Examining the Paracrine Effects of Exosomes in Cardiovascular Disease and Repair. J. Am. Heart Assoc. 2018, 7, e007954.
    • (2018) J. Am. Heart Assoc. , vol.7
    • Gartz, M.1    Strande, J.L.2
  • 167
    • 84935874875 scopus 로고    scopus 로고
    • Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury
    • Zhao, Y.; Sun, X.; Cao, W.; Ma, J.; Sun, L.; Qian, H.; Zhu, W.; Xu, W. Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Acute Myocardial Ischemic Injury. Stem Cells Int. 2015, 2015, 761643.
    • (2015) Stem Cells Int , vol.2015
    • Zhao, Y.1    Sun, X.2    Cao, W.3    Ma, J.4    Sun, L.5    Qian, H.6    Zhu, W.7    Xu, W.8
  • 169
    • 84898461927 scopus 로고    scopus 로고
    • Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
    • Bian, S.; Zhang, L.; Duan, L.; Wang, X.; Min, Y.; Yu, H. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J. Mol. Med. 2014, 92, 387–397.
    • (2014) J. Mol. Med. , vol.92 , pp. 387-397
    • Bian, S.1    Zhang, L.2    Duan, L.3    Wang, X.4    Min, Y.5    Yu, H.6
  • 170
    • 85020183187 scopus 로고    scopus 로고
    • Exosomes from Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/beta-Catenin Signaling Pathway
    • Cui, X.; He, Z.; Liang, Z.; Chen, Z.; Wang, H.; Zhang, J. Exosomes from Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/beta-Catenin Signaling Pathway. J. Cardiovasc. Pharmacol. 2017, 70, 225–231.
    • (2017) J. Cardiovasc. Pharmacol. , vol.70 , pp. 225-231
    • Cui, X.1    He, Z.2    Liang, Z.3    Chen, Z.4    Wang, H.5    Zhang, J.6
  • 171
    • 84997815986 scopus 로고    scopus 로고
    • Pretreatment of Cardiac Stem Cells with Exosomes Derived from Mesenchymal Stem Cells Enhances Myocardial Repair
    • Zhang, Z.; Yang, J.; Yan, W.; Li, Y.; Shen, Z.; Asahara, T. Pretreatment of Cardiac Stem Cells with Exosomes Derived from Mesenchymal Stem Cells Enhances Myocardial Repair. J. Am. Heart Assoc. 2016, 5, e002856.
    • (2016) J. Am. Heart Assoc. , vol.5
    • Zhang, Z.1    Yang, J.2    Yan, W.3    Li, Y.4    Shen, Z.5    Asahara, T.6
  • 172
    • 85015842105 scopus 로고    scopus 로고
    • Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction
    • Gallet, R.; Dawkins, J.; Valle, J.; Simsolo, E.; de Couto, G.; Middleton, R.; Tseliou, E.; Luthringer, D.; Kreke, M.; Smith, R.R.; et al. Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. Eur. Heart J. 2017, 38, 201–211.
    • (2017) Eur. Heart J. , vol.38 , pp. 201-211
    • Gallet, R.1    Dawkins, J.2    Valle, J.3    Simsolo, E.4    de Couto, G.5    Middleton, R.6    Tseliou, E.7    Luthringer, D.8    Kreke, M.9    Smith, R.R.10
  • 173
    • 84945407964 scopus 로고    scopus 로고
    • Proteomics characterization of exosome cargo
    • Schey, K.L.; Luther, J.M.; Rose, K.L. Proteomics characterization of exosome cargo. Methods 2015, 87, 75–82.
    • (2015) Methods , vol.87 , pp. 75-82
    • Schey, K.L.1    Luther, J.M.2    Rose, K.L.3
  • 175
    • 84866524463 scopus 로고    scopus 로고
    • Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome
    • Lai, R.C.; Tan, S.S.; Teh, B.J.; Sze, S.K.; Arslan, F.; de Kleijn, D.P.; Choo, A.; Lim, S.K. Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome. Int. J. Proteom. 2012, 2012, 971907.
    • (2012) Int. J. Proteom. , vol.2012
    • Lai, R.C.1    Tan, S.S.2    Teh, B.J.3    Sze, S.K.4    Arslan, F.5    de Kleijn, D.P.6    Choo, A.7    Lim, S.K.8
  • 176
    • 84924973691 scopus 로고    scopus 로고
    • Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites
    • Vallabhaneni, K.C.; Penfornis, P.; Dhule, S.; Guillonneau, F.; Adams, K.V.; Mo, Y.Y.; Xu, R.; Liu, Y.; Watabe, K.; Vemuri, M.C.; et al. Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites. Oncotarget 2015, 6, 4953–4967.
    • (2015) Oncotarget , vol.6 , pp. 4953-4967
    • Vallabhaneni, K.C.1    Penfornis, P.2    Dhule, S.3    Guillonneau, F.4    Adams, K.V.5    Mo, Y.Y.6    Xu, R.7    Liu, Y.8    Watabe, K.9    Vemuri, M.C.10
  • 178
    • 84872063933 scopus 로고    scopus 로고
    • AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: Role for proangiogenic effects and alterations in type 2 diabetics
    • Mocharla, P.; Briand, S.; Giannotti, G.; Dorries, C.; Jakob, P.; Paneni, F.; Luscher, T.; Landmesser, U. AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: Role for proangiogenic effects and alterations in type 2 diabetics. Blood 2013, 121, 226–236.
    • (2013) Blood , vol.121 , pp. 226-236
    • Mocharla, P.1    Briand, S.2    Giannotti, G.3    Dorries, C.4    Jakob, P.5    Paneni, F.6    Luscher, T.7    Landmesser, U.8
  • 179
    • 84922105441 scopus 로고    scopus 로고
    • Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology
    • Gray, W.D.; French, K.M.; Ghosh-Choudhary, S.; Maxwell, J.T.; Brown, M.E.; Platt, M.O.; Searles, C.D.; Davis, M.E. Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology. Circ. Res. 2015, 116, 255–263.
    • (2015) Circ. Res. , vol.116 , pp. 255-263
    • Gray, W.D.1    French, K.M.2    Ghosh-Choudhary, S.3    Maxwell, J.T.4    Brown, M.E.5    Platt, M.O.6    Searles, C.D.7    Davis, M.E.8
  • 181
    • 85021795571 scopus 로고    scopus 로고
    • The metabolic syndrome alters the miRNA signature of porcine adipose tissue-derived mesenchymal stem cells
    • Meng, Y.; Eirin, A.; Zhu, X.Y.; Tang, H.; Chanana, P.; Lerman, A.; Van Wijnen, A.J.; Lerman, L.O. The metabolic syndrome alters the miRNA signature of porcine adipose tissue-derived mesenchymal stem cells. Cytom. Part A 2018, 93, 93–103.
    • (2018) Cytom. Part A , vol.93 , pp. 93-103
    • Meng, Y.1    Eirin, A.2    Zhu, X.Y.3    Tang, H.4    Chanana, P.5    Lerman, A.6    van Wijnen, A.J.7    Lerman, L.O.8
  • 184
    • 85052065143 scopus 로고    scopus 로고
    • Genome, transcriptome and proteome: The rise of omics data and their integration in biomedical sciences
    • Manzoni, C.; Kia, D.A.; Vandrovcova, J.; Hardy, J.; Wood, N.W.; Lewis, P.A.; Ferrari, R. Genome, transcriptome and proteome: The rise of omics data and their integration in biomedical sciences. Brief. Bioinform. 2018, 19, 286–302.
    • (2018) Brief. Bioinform. , vol.19 , pp. 286-302
    • Manzoni, C.1    Kia, D.A.2    Vandrovcova, J.3    Hardy, J.4    Wood, N.W.5    Lewis, P.A.6    Ferrari, R.7
  • 185
    • 85062653841 scopus 로고    scopus 로고
    • Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach
    • Vilne, B.; Schunkert, H. Integrating Genes Affecting Coronary Artery Disease in Functional Networks by Multi-OMICs Approach. Front. Cardiovasc. Med. 2018, 5, 89, doi:10.3389/fcvm.2018.00089.
    • (2018) Front. Cardiovasc. Med. , vol.5 , pp. 89
    • Vilne, B.1    Schunkert, H.2
  • 186
    • 85032453667 scopus 로고    scopus 로고
    • Single-Cell Sequencing Technologies for Cardiac Stem Cell Studies
    • Liu, T.; Wu, H.; Wu, S.; Wang, C. Single-Cell Sequencing Technologies for Cardiac Stem Cell Studies. Stem Cells Dev. 2017, 26, 1540–1551.
    • (2017) Stem Cells Dev , vol.26 , pp. 1540-1551
    • Liu, T.1    Wu, H.2    Wu, S.3    Wang, C.4


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