Downregulation of HDAC1 is involved in the cardiomyocyte differentiation from mesenchymal stem cells in a myocardial microenvironment

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Lu, Dong Feng ^a   Yao, Yan ^a   Su, Zi Zhuo ^a   Zeng, Zhao Hua ^a   Xing, Xiao Wen ^a   He, Zhi Yu ^a   Zhang, Chunxiang ^b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b RUSH MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; HISTONE DEACETYLASE 1; TROPONIN T; MEMBRANE ANTIGEN; MESSENGER RNA;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME REGULATION; FLOW CYTOMETRY; HEART MUSCLE; HEART MUSCLE CELL; IMMUNOFLUORESCENCE TEST; MALE; MESENCHYMAL STEM CELL; MUSCLE TISSUE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TISSUE STRUCTURE; WESTERN BLOTTING; ANIMAL; CULTURE TECHNIQUE; CYTOLOGY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSDUCTION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PHENOTYPE; REPORTER GENE; TUMOR MICROENVIRONMENT;

ANIMALS; ANTIGENS, SURFACE; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLULAR MICROENVIRONMENT; COCULTURE TECHNIQUES; DOWN-REGULATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, REPORTER; HISTONE DEACETYLASE 1; MALE; MESENCHYMAL STROMAL CELLS; MYOCYTES, CARDIAC; PHENOTYPE; RATS; RNA, MESSENGER; TRANSDUCTION, GENETIC; TROPONIN T;

EID: 84898670852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093222     Document Type: Article

References (17)

1. Xu M, Wani M, Dai YS, Wang J, Yan M, et al. (2004) Differentiation of bone marrow stromal cells into the cardiac phenotype requires intercellular communication w (Pubitemid 39453016)
2. Leu YW, Huang TH, Hsiao SH. (2013) Epigenetic reprogramming of mesenchymal stem cells. Adv Exp Med Biol 754:195-211.
3. Xu S, De Veirman K, Evans H, Santini GC, Vande Broek I, et al. (2013) Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo. Acta Pharmacol Sin 34:699-709.
4. Collas P. (2009) Epigenetic states in stem cells. Biochim Biophys Acta 1790:900-905.
5. Feng C, Zhu J, Zhao L, Lu T, Zhang W, et al. (2009) Suberoylanilide hydroxamic acid promotes cardiomyocyte differentiation of rat mesenchymal stem cells. Exp Cell Res 315:3044-3051.
6. Muscari C, Bonafé F, Carboni M, Govoni M, Stanic I, et al. (2008). Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes. J Cell Biochem 103:1046-1052. (Pubitemid 351342598)
7. Zhu J, Wang Y, Zhang XP, Wang JJ, Zhang XF, et al. (2006) Constructions of Gcn5 shRNAs interfere the histone acetylation modification with stem cell differentiation. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:43-46. (Pubitemid 43241931)
8. Li H, Yu B, Zhang Y, Pan Z, Xu W, et al. (2006) Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes. Biochem Biophys Res Commun 41:320-325 (Pubitemid 43152109)
9. Huang XP, Sun Z, Miyagi Y, McDonald KH, Zhang L, et al. (2010) Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation 122:2419-2429.
10. Cheng Y, Zhu P, Yang J, Liu X, Dong S, et al. (2010) Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res 87:431-439.
11. Cheng Y, Tan N, Yang J, Liu X, Cao X, et al. (2010) A translational study of circulating cell-free microRNA-1 in acute myocardial infarction. Clin Sci (Lond) 119: 87-95.
12. Snykers S, Vanhaecke T, De Becker A, Papeleu P, Vinken M, et al. (2007) Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. BMC Dev Biol 7:24.
13. Mahpatra S, Firpo MT, Bacanamwo M. (2010) Inhibition of DNA methyltransferases and histone deacetylases induces bone marrow-derived multipotent adult progenitor cells to differentiate into endothelial cells. Ethn Dis 20:S1-S60.
14. Wang JP, Wen MH, Chen YT, Lee HH, Chiang ER, et al. (2011) Trichostatin A inhibits TGF-beta1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression. Differentiation 81:119-126.
15. Haberland M, Carrer M, Mokalled MH, Montgomery RL, Olson EN, et al. (2010) Redundant control of adipogenesis by histone deacetylases 1 and 2. J Biol Chem 285:14663-14670.
16. Dovey OM, Foster CT, Cowley SM. (2010) Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci USA 107:8242-8247.
17. Liu Z, Li T, Liu Y, Jia Y, Li C, et al. (2009) WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1. Biochim Biophys Acta 1793:300-311.