Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Kim, Myungshin ^a,b   Rhee, Je Keun ^a   Choi, Hayoung ^b   Kwon, Ahlm ^b   Kim, Jiyeon ^b   Lee, Gun Dong ^b   Jekarl, Dong Wook ^a,b   Lee, Seungok ^a,b   Kim, Yonggoo ^a,b   Kim, Tae Min ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELL PROLIFERATION; CLONAL VARIATION; GENE AMPLIFICATION; GENE FREQUENCY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFORMATION PROCESSING; INTRON; MESENCHYMAL STROMA CELL; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; STRESS; STROMAL CELL LINE; WHOLE GENOME SEQUENCING; ADOLESCENT; ADULT; CELL CULTURE TECHNIQUE; CELL LINE; FEMALE; GENETICS; MALE; MESENCHYMAL STEM CELL; METABOLISM; MUTATION; PHYSIOLOGICAL STRESS; PHYSIOLOGY; TELOMERE HOMEOSTASIS;

ADOLESCENT; ADULT; CELL CULTURE TECHNIQUES; CELL LINE; CELL PROLIFERATION; FEMALE; HUMANS; MALE; MESENCHYMAL STEM CELLS; MUTATION; STRESS, PHYSIOLOGICAL; TELOMERE HOMEOSTASIS; WHOLE GENOME SEQUENCING;

EID: 85032982297     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-15155-5     Document Type: Article

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