메뉴 건너뛰기




Volumn 9, Issue 9, 2003, Pages 1195-1201

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; PROTEIN KINASE B;

EID: 0141796313     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm912     Document Type: Article
Times cited : (1401)

References (45)
  • 1
    • 0033797702 scopus 로고    scopus 로고
    • Protective responses in the ischemic myocardium
    • Williams, R.S. & Benjamin, I.J. Protective responses in the ischemic myocardium. J. Clin. Invest. 106, 813-818 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 813-818
    • Williams, R.S.1    Benjamin, I.J.2
  • 3
    • 0035821988 scopus 로고    scopus 로고
    • Evidence that human cardiac myocytes divide after myocardial infarction
    • Beltrami, A.P. et al. Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med. 344, 1750-1757 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1750-1757
    • Beltrami, A.P.1
  • 4
    • 0034988491 scopus 로고    scopus 로고
    • Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    • Jackson, K.A. et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107, 1395-1402 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 1395-1402
    • Jackson, K.A.1
  • 5
    • 0037012139 scopus 로고    scopus 로고
    • Chimerism of the transplanted heart
    • Quaini, F. et al. Chimerism of the transplanted heart. N. Engl. J. Med. 346, 5-15 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 5-15
    • Quaini, F.1
  • 6
    • 0344672626 scopus 로고    scopus 로고
    • Autologous transplantation of bone marrow cells improves damaged heart function
    • Tomita, S. et al. Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 100, 11247-256 (1999).
    • (1999) Circulation , vol.100 , pp. 11247-11256
    • Tomita, S.1
  • 7
    • 0033746306 scopus 로고    scopus 로고
    • Marrow stromal cells for cellular cardiomyoplasty: Feasibility and potential clinical advantages
    • Wang, J.S. et al. Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. J. Thorac. Cardiovasc. Surg. 120, 999-1005 (2000).
    • (2000) J. Thorac. Cardiovasc. Surg. , vol.120 , pp. 999-1005
    • Wang, J.S.1
  • 8
    • 0035810240 scopus 로고    scopus 로고
    • Bone marrow cells regenerate infarcted myocardium
    • Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705 (2001).
    • (2001) Nature , vol.410 , pp. 701-705
    • Orlic, D.1
  • 9
    • 0035044085 scopus 로고    scopus 로고
    • Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
    • Kocher, A.A. et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. 7, 430-436 (2001).
    • (2001) Nat. Med. , vol.7 , pp. 430-436
    • Kocher, A.A.1
  • 10
    • 0035814766 scopus 로고    scopus 로고
    • Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia
    • Kawamoto, A. et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 103, 634-637 (2001).
    • (2001) Circulation , vol.103 , pp. 634-637
    • Kawamoto, A.1
  • 11
    • 0029000896 scopus 로고
    • Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice
    • Pereira, R.F. et al. Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc. Natl. Acad. Sci. USA 92, 4857-4861 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4857-4861
    • Pereira, R.F.1
  • 12
    • 0032584132 scopus 로고    scopus 로고
    • Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - Similarities to astrocyte grafts
    • Azizi, S.A. et al. Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - similarities to astrocyte grafts. Proc. Natl. Acad. Sci. USA 95, 3908-3913 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3908-3913
    • Azizi, S.A.1
  • 13
    • 0035881367 scopus 로고    scopus 로고
    • Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats
    • Chen, J. et al. Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J. Neurol. Sci. 189, 49-57 (2001).
    • (2001) J. Neurol. Sci. , vol.189 , pp. 49-57
    • Chen, J.1
  • 14
    • 0032489651 scopus 로고    scopus 로고
    • Muscle regeneration by bone marrow-derived myogenic progenitors
    • Ferrari, G. et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279, 1528-1530 (1998).
    • (1998) Science , vol.279 , pp. 1528-1530
    • Ferrari, G.1
  • 15
    • 0033106384 scopus 로고    scopus 로고
    • Cardiomyocytes can be generated from marrow stromal cells in vitro
    • Makino, S. et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103, 697-705 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 697-705
    • Makino, S.1
  • 16
    • 0036142213 scopus 로고    scopus 로고
    • Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    • Toma, C. et al. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105, 93-98 (2002).
    • (2002) Circulation , vol.105 , pp. 93-98
    • Toma, C.1
  • 17
    • 0036266426 scopus 로고    scopus 로고
    • Mesenchymal stem cell implantation in a swine myocardial infarct model: Engraftment and functional effects
    • Shake, J.G. et al. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann. Thorac. Surg. 73, 1919-1925, 1926 (2002).
    • (2002) Ann. Thorac. Surg. , vol.73 , pp. 1919-1925
    • Shake, J.G.1
  • 18
    • 0033551487 scopus 로고    scopus 로고
    • Survival, integration, and differentiation of cardiomyocyte grafts: A study in normal and injured rat hearts
    • Reinecke, H., Zhang, M., Bartosek, T. & Murry, C.E. Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts. Circulation 100, 193-202 (1999).
    • (1999) Circulation , vol.100 , pp. 193-202
    • Reinecke, H.1    Zhang, M.2    Bartosek, T.3    Murry, C.E.4
  • 19
    • 0034971110 scopus 로고    scopus 로고
    • Cardiomyocyte grafting for cardiac repair: Graft cell death and anti-death strategies
    • Zhang, M. et al. Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J. Mol. Cell. Cardiol. 33, 907-921 (2001).
    • (2001) J. Mol. Cell. Cardiol. , vol.33 , pp. 907-921
    • Zhang, M.1
  • 20
    • 0036462783 scopus 로고    scopus 로고
    • Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium
    • Muller-Ehmsen, J. et al. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J. Mol. Cell. Cardiol. 34, 107-116 (2002).
    • (2002) J. Mol. Cell. Cardiol. , vol.34 , pp. 107-116
    • Muller-Ehmsen, J.1
  • 21
    • 0030907987 scopus 로고    scopus 로고
    • PI3K: Downstream AKTion blocks apoptosis
    • Franke, T.F., Kaplan, D.R. & Cantley, L.C. PI3K: downstream AKTion blocks apoptosis. Cell 88, 435-437 (1997).
    • (1997) Cell , vol.88 , pp. 435-437
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3
  • 22
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S.R., Brunet, A. & Greenberg, M.E. Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 23
    • 0034724369 scopus 로고    scopus 로고
    • Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow
    • Colter, D.C., Class, R., DiGirolamo, C.M. & Prockop, D.J. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc. Natl. Acad. Sci. USA 97, 3213-3218 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3213-3218
    • Colter, D.C.1    Class, R.2    DiGirolamo, C.M.3    Prockop, D.J.4
  • 24
    • 0032895389 scopus 로고    scopus 로고
    • Thrombopoietin combined with early-acting growth factors effectively expands human hematopoietic progenitor cells in vitro
    • Hunnestad, J.A., Steen, R., Tjonnfjord, G.E. & Egeland, T. Thrombopoietin combined with early-acting growth factors effectively expands human hematopoietic progenitor cells in vitro. Stem Cells 17, 31-38 (1999).
    • (1999) Stem Cells , vol.17 , pp. 31-38
    • Hunnestad, J.A.1    Steen, R.2    Tjonnfjord, G.E.3    Egeland, T.4
  • 25
    • 0037041427 scopus 로고    scopus 로고
    • Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
    • Terada, N. et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416, 542-545 (2002).
    • (2002) Nature , vol.416 , pp. 542-545
    • Terada, N.1
  • 26
    • 0037041428 scopus 로고    scopus 로고
    • Changing potency by spontaneous fusion
    • Ying, Q.L., Nichols, J., Evans, E.P. & Smith, A.G. Changing potency by spontaneous fusion. Nature 416, 545-548 (2002).
    • (2002) Nature , vol.416 , pp. 545-548
    • Ying, Q.L.1    Nichols, J.2    Evans, E.P.3    Smith, A.G.4
  • 27
    • 0031928026 scopus 로고    scopus 로고
    • Regenerating functional myocardium: Improved performance after skeletal myoblast transplantation
    • Taylor, D.A. et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat. Med. 4, 929-933 (1998).
    • (1998) Nat. Med. , vol.4 , pp. 929-933
    • Taylor, D.A.1
  • 28
    • 0029844930 scopus 로고    scopus 로고
    • Skeletal myoblast transplantation for repair of myocardial necrosis
    • Murry, C.E., Wiseman, R.W., Schwartz, S.M. & Hauschka, S.D. Skeletal myoblast transplantation for repair of myocardial necrosis. J. Clin. Invest. 98, 2512-2523 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 2512-2523
    • Murry, C.E.1    Wiseman, R.W.2    Schwartz, S.M.3    Hauschka, S.D.4
  • 29
    • 0032809114 scopus 로고    scopus 로고
    • Cellular cardiomyoplasty improves diastolic properties of injured heart
    • Atkins, B.Z. et al. Cellular cardiomyoplasty improves diastolic properties of injured heart. J. Surg. Res. 85, 234-242 (1999).
    • (1999) J. Surg. Res. , vol.85 , pp. 234-242
    • Atkins, B.Z.1
  • 30
    • 0035956699 scopus 로고    scopus 로고
    • Myoblast transplantation for heart failure
    • Menasche, P. et al. Myoblast transplantation for heart failure. Lancet 357, 279-280 (2001).
    • (2001) Lancet , vol.357 , pp. 279-280
    • Menasche, P.1
  • 31
    • 0034194209 scopus 로고    scopus 로고
    • Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair
    • Reinecke, H., MacDonald, G.H., Hauschka, S.D. & Murry, C.E. Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair. J. Cell. Biol. 149, 731-740 (2000).
    • (2000) J. Cell. Biol. , vol.149 , pp. 731-740
    • Reinecke, H.1    MacDonald, G.H.2    Hauschka, S.D.3    Murry, C.E.4
  • 32
    • 0034538534 scopus 로고    scopus 로고
    • Transmural replacement of myocardium after skeletal myoblast grafting into the heart. Too much of a good thing?
    • Reinecke, H. & Murry, C.E. Transmural replacement of myocardium after skeletal myoblast grafting into the heart. Too much of a good thing? Cardiovasc. Pathol. 9, 337-(2000).
    • (2000) Cardiovasc. Pathol. , vol.9 , pp. 337
    • Reinecke, H.1    Murry, C.E.2
  • 33
    • 0342871963 scopus 로고    scopus 로고
    • Natural history of fetal rat cardiomyocytes transplanted into adult rat myocardial scar tissue
    • Li, R.K. et al. Natural history of fetal rat cardiomyocytes transplanted into adult rat myocardial scar tissue. Circulation 96, 11-179-186, 186-177 (1997).
    • (1997) Circulation , vol.96 , pp. 11179-11186
    • Li, R.K.1
  • 34
    • 0031841732 scopus 로고    scopus 로고
    • Cardiomyocyte transplantation in a porcine myocardial infarction model
    • Watanabe, E. et al. Cardiomyocyte transplantation in a porcine myocardial infarction model. Cell Transplant. 7, 239-246 (1998).
    • (1998) Cell Transplant. , vol.7 , pp. 239-246
    • Watanabe, E.1
  • 35
    • 0036092735 scopus 로고    scopus 로고
    • Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats
    • Min, J.Y. et al. Transplantation of embryonic stem cells improves cardiac function in postinfarcted rats. J. Appl. Physiol. 92, 288-296 (2002).
    • (2002) J. Appl. Physiol. , vol.92 , pp. 288-296
    • Min, J.Y.1
  • 36
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • Fujio, Y. et al. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101, 660-667 (2000).
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1
  • 37
    • 0037151104 scopus 로고    scopus 로고
    • Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
    • Matsui, T. et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J. Biol. Chem. 277, 22896-22901 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 22896-22901
    • Matsui, T.1
  • 38
    • 0035907390 scopus 로고    scopus 로고
    • Akt participation in the Wnt signaling pathway through Dishevelled
    • Fukumoto, S. et al. Akt participation in the Wnt signaling pathway through Dishevelled. J. Biol. Chem. 276, 17479-17483 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 17479-17483
    • Fukumoto, S.1
  • 39
    • 0037022253 scopus 로고    scopus 로고
    • Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene
    • Melo, L.G. et al. Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase gene. Circulation 105, 602-607 (2002).
    • (2002) Circulation , vol.105 , pp. 602-607
    • Melo, L.G.1
  • 40
    • 17944371854 scopus 로고    scopus 로고
    • Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    • Orlic, D. et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. USA 98, 10344-10349 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10344-10349
    • Orlic, D.1
  • 41
    • 0035975982 scopus 로고    scopus 로고
    • Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction
    • Nwogu, J. et al. Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. Circulation 104, 2216-2221 (2001).
    • (2001) Circulation , vol.104 , pp. 2216-2221
    • Nwogu, J.1
  • 42
    • 0032694866 scopus 로고    scopus 로고
    • Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
    • Choukroun, G. et al. Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases. J. Clin. Invest. 104, 391-398 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 391-398
    • Choukroun, G.1
  • 43
    • 0032523194 scopus 로고    scopus 로고
    • Diastolic dysfunction and altered energetics in the αMHC403/+ mouse model of familial hypertrophic cardiomyopathy
    • Spindler, M. et al. Diastolic dysfunction and altered energetics in the αMHC403/+ mouse model of familial hypertrophic cardiomyopathy. J. Clin. Invest. 101, 1775-1783 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 1775-1783
    • Spindler, M.1
  • 44
    • 0034613381 scopus 로고    scopus 로고
    • Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation
    • Okano, J. et al. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J. Biol. Chem. 275, 30934-30942 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 30934-30942
    • Okano, J.1
  • 45
    • 0035513703 scopus 로고    scopus 로고
    • Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
    • Teruel, T., Hernandez, R. & Lorenzo, M. Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 50, 2563-2571 (2001).
    • (2001) Diabetes , vol.50 , pp. 2563-2571
    • Teruel, T.1    Hernandez, R.2    Lorenzo, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.