Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction

European Heart Journal

Volumn 38, Issue 3, 2017, Pages 201-211

  Gallet, Romain ^a,b   Dawkins, James ^a   Valle, Jackelyn ^a   Simsolo, Eli ^a   De Couto, Geoffrey ^a   Middleton, Ryan ^a   Tseliou, Eleni ^a   Luthringer, Daniel ^a   Kreke, Michelle ^a,c   Smith, Rachel R ^c   Marbán, Linda ^a,c   Ghaleh, Bijan ^b   Marbán, Eduardo ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b INSERM U955   (France)

^c Capricor Inc   (United States)

Author keywords

Animal models; Cell therapy; Exosomes; Myocardial infarction

Indexed keywords

CELL THERAPY AGENT; COLLAGEN; NANOPARTICLE; PLACEBO;

ACUTE HEART INFARCTION; ADULT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; CARDIAC MUSCLE CELL; CARDIOSPHERE DERIVED CELL; CELL INFILTRATION; CONTROLLED STUDY; CONVALESCENT MYOCARDIAL INFARCTION; DRUG DELIVERY SYSTEM; DRUG RETENTION; EXOSOME; FEMALE; HEART DISEASE; HEART FUNCTION; HEART INFARCTION SIZE; HEART INJURY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE REPERFUSION; HISTOLOGY; HUMAN; HUMAN CELL; HYPERTROPHIC CARDIOMYOPATHY; IMMUNOGENICITY; INTRACORONARY DRUG ADMINISTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PIG; PRECLINICAL STUDY; SCAR FORMATION; SINUS RHYTHM; TUNEL ASSAY; ACUTE DISEASE; ANIMAL; CARDIAC MUSCLE; CHRONIC DISEASE; DISEASE MODEL; HEART INFARCTION; HEART VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; MAGNETIC RESONANCE ANGIOGRAPHY; METABOLISM; MINIPIG; MULTICELLULAR SPHEROID; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; REGENERATION; SCAR; SECRETION (PROCESS); TRANSPLANTATION;

ACUTE DISEASE; ANIMALS; CHRONIC DISEASE; CICATRIX; DISEASE MODELS, ANIMAL; EXOSOMES; FEMALE; MAGNETIC RESONANCE ANGIOGRAPHY; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; RANDOM ALLOCATION; REGENERATION; SPHEROIDS, CELLULAR; SWINE; SWINE, MINIATURE; VENTRICULAR FUNCTION; VENTRICULAR REMODELING;

EID: 85015842105     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehw240     Document Type: Article

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