-
1
-
-
77950800100
-
Totipotency, pluripotency and nuclear reprogramming
-
Springer Berlin Heidelberg
-
1 Mitalipov, S., Wolf, D., Totipotency, pluripotency and nuclear reprogramming. Engineering of Stem Cells, 2009, Springer Berlin Heidelberg, 185–199.
-
(2009)
Engineering of Stem Cells
, pp. 185-199
-
-
Mitalipov, S.1
Wolf, D.2
-
2
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
2 Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., Yamanaka, S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131 (2007), 861–872.
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
Yamanaka, S.7
-
3
-
-
84936998148
-
Stem cell therapies in clinical trials: progress and challenges
-
3 Trounson, A., McDonald, C., Stem cell therapies in clinical trials: progress and challenges. Cell Stem Cell 17 (2015), 11–22.
-
(2015)
Cell Stem Cell
, vol.17
, pp. 11-22
-
-
Trounson, A.1
McDonald, C.2
-
4
-
-
84964058436
-
Metaboloepigenetics: the emerging network in stem cell homeostasis regulation
-
4 Avitabile, D., Magenta, A., Lauri, A., Gambini, E., Spaltro, G., Vinci, M.C., Metaboloepigenetics: the emerging network in stem cell homeostasis regulation. Curr Stem Cell Res Ther 11 (2016), 352–369.
-
(2016)
Curr Stem Cell Res Ther
, vol.11
, pp. 352-369
-
-
Avitabile, D.1
Magenta, A.2
Lauri, A.3
Gambini, E.4
Spaltro, G.5
Vinci, M.C.6
-
5
-
-
84900332195
-
Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells
-
This study demonstrated that hPSCs require high levels of methionine for survival and maintenance of the pluripotent state. Short term deficiency of methionine led to histone demethylation and differentiation while long term deprivation led to apoptosis.
-
5•• Shiraki, N., Shiraki, Y., Tsuyama, T., Obata, F., Miura, M., Nagae, G., Aburatani, H., Kume, K., Endo, F., Kume, S., Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells. Cell Metab 19 (2014), 780–794 This study demonstrated that hPSCs require high levels of methionine for survival and maintenance of the pluripotent state. Short term deficiency of methionine led to histone demethylation and differentiation while long term deprivation led to apoptosis.
-
(2014)
Cell Metab
, vol.19
, pp. 780-794
-
-
Shiraki, N.1
Shiraki, Y.2
Tsuyama, T.3
Obata, F.4
Miura, M.5
Nagae, G.6
Aburatani, H.7
Kume, K.8
Endo, F.9
Kume, S.10
-
6
-
-
84948669098
-
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
-
The authors showed that upregulation of H3K27me3 repressive epigenetic marks during the naive-to-primed hESC transition is controlled by the metabolic enzyme nicotinamide N-methyltransferase which converts SAM to 1-methylnicotinamide.
-
6•• Sperber, H., Mathieu, J., Wang, Y., Ferreccio, A., Hesson, J., Xu, Z., Fischer, K.A., Devi, A., Detraux, D., Gu, H., et al. The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. Nat Cell Biol 17 (2015), 1523–1535 The authors showed that upregulation of H3K27me3 repressive epigenetic marks during the naive-to-primed hESC transition is controlled by the metabolic enzyme nicotinamide N-methyltransferase which converts SAM to 1-methylnicotinamide.
-
(2015)
Nat Cell Biol
, vol.17
, pp. 1523-1535
-
-
Sperber, H.1
Mathieu, J.2
Wang, Y.3
Ferreccio, A.4
Hesson, J.5
Xu, Z.6
Fischer, K.A.7
Devi, A.8
Detraux, D.9
Gu, H.10
-
7
-
-
84924369505
-
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells
-
The authors provide evidence for the role of glycolysis in maintaining pluripotency via acetyl-CoA-mediated changes in histone acetylation.
-
7• Moussaieff, A., Rouleau, M., Kitsberg, D., Cohen, M., Levy, G., Barasch, D., Nemirovski, A., Shen-Orr, S., Laevsky, I., Amit, M., et al. Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metab 21 (2015), 392–402 The authors provide evidence for the role of glycolysis in maintaining pluripotency via acetyl-CoA-mediated changes in histone acetylation.
-
(2015)
Cell Metab
, vol.21
, pp. 392-402
-
-
Moussaieff, A.1
Rouleau, M.2
Kitsberg, D.3
Cohen, M.4
Levy, G.5
Barasch, D.6
Nemirovski, A.7
Shen-Orr, S.8
Laevsky, I.9
Amit, M.10
-
8
-
-
77952545479
-
Metabolic oxidation regulates embryonic stem cell differentiation
-
8 Yanes, O., Clark, J., Wong, D.M., Patti, G.J., Sánchez-Ruiz, A., Benton, H.P., Trauger, S.a, Desponts, C., Ding, S., Siuzdak, G., Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol 6 (2010), 411–417.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 411-417
-
-
Yanes, O.1
Clark, J.2
Wong, D.M.3
Patti, G.J.4
Sánchez-Ruiz, A.5
Benton, H.P.6
Trauger, S.A.7
Desponts, C.8
Ding, S.9
Siuzdak, G.10
-
9
-
-
84930216251
-
Single-cell mass spectrometry reveals small molecules that affect cell fates in the 16-cell embryo
-
Using single cell technology, the authors provided direct evidence for differential abundance of metabolites within the cells of the embryo with different tissue fates. Altering the abundance of several metabolites such as threonine, serine, methionine and acetylcholine in the blastomeres affected development and cell fate.
-
9•• Onjiko, R.M., Moody, S.a., Nemes, P., Single-cell mass spectrometry reveals small molecules that affect cell fates in the 16-cell embryo. Proc Natl Acad Sci U S A 112 (2015), 6545–6550 Using single cell technology, the authors provided direct evidence for differential abundance of metabolites within the cells of the embryo with different tissue fates. Altering the abundance of several metabolites such as threonine, serine, methionine and acetylcholine in the blastomeres affected development and cell fate.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 6545-6550
-
-
Onjiko, R.M.1
Moody, S.A.2
Nemes, P.3
-
10
-
-
84878420641
-
Metabolomics: the apogee of the omics trilogy
-
10 Mathew, A.K., Padmanaban, V.C., Metabolomics: the apogee of the omics trilogy. Int J Pharm Pharm Sci 5 (2013), 45–48.
-
(2013)
Int J Pharm Pharm Sci
, vol.5
, pp. 45-48
-
-
Mathew, A.K.1
Padmanaban, V.C.2
-
11
-
-
84855490988
-
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming
-
11 Panopoulos, A.D., Yanes, O., Ruiz, S., Kida, Y.S., Diep, D., Tautenhahn, R., Herrerías, A., Batchelder, E.M., Plongthongkum, N., Lutz, M., et al. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming. Cell Res 22 (2012), 168–177.
-
(2012)
Cell Res
, vol.22
, pp. 168-177
-
-
Panopoulos, A.D.1
Yanes, O.2
Ruiz, S.3
Kida, Y.S.4
Diep, D.5
Tautenhahn, R.6
Herrerías, A.7
Batchelder, E.M.8
Plongthongkum, N.9
Lutz, M.10
-
12
-
-
84889591862
-
Metabolomics in cancer biomarker discovery: current trends and future perspectives
-
12 Armitage, E.G., Barbas, C., Metabolomics in cancer biomarker discovery: current trends and future perspectives. J Pharm Biomed Anal 87 (2014), 1–11.
-
(2014)
J Pharm Biomed Anal
, vol.87
, pp. 1-11
-
-
Armitage, E.G.1
Barbas, C.2
-
13
-
-
77954817641
-
Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics
-
13 West, P.R., Weir, A.M., Smith, A.M., Donley, E.L.R., Cezar, G.G., Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics. Toxicol Appl Pharmacol 247 (2010), 18–27.
-
(2010)
Toxicol Appl Pharmacol
, vol.247
, pp. 18-27
-
-
West, P.R.1
Weir, A.M.2
Smith, A.M.3
Donley, E.L.R.4
Cezar, G.G.5
-
14
-
-
84868351585
-
Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal
-
14 Zhang, J., Nuebel, E., Daley, G.Q., Koehler, C.M., Teitell, M.A., Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell 11 (2012), 589–595.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 589-595
-
-
Zhang, J.1
Nuebel, E.2
Daley, G.Q.3
Koehler, C.M.4
Teitell, M.A.5
-
15
-
-
79960945131
-
Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
-
15 Folmes, C.D.L., Nelson, T.J., Martinez-Fernandez, A., Arrell, D.K., Lindor, J.Z., Dzeja, P.P., Ikeda, Y., Perez-Terzic, C., Terzic, A., Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab 14 (2011), 264–271.
-
(2011)
Cell Metab
, vol.14
, pp. 264-271
-
-
Folmes, C.D.L.1
Nelson, T.J.2
Martinez-Fernandez, A.3
Arrell, D.K.4
Lindor, J.Z.5
Dzeja, P.P.6
Ikeda, Y.7
Perez-Terzic, C.8
Terzic, A.9
-
16
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
16 Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324 (2009), 1029–1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
17
-
-
84947475040
-
Improvement in mouse iPSC induction by Rab32 reveals the importance of lipid metabolism during reprogramming
-
The authors describe upregulation of lipid biosynthesis during iPSC reprogramming mediated by Oct4, Sox2, Klf4, and Rab32. Inhibition of lipid biosynthesis reduced the reprogramming efficiency highlighting the importance of lipid metabolism during reprogramming.
-
17• Pei, Y., Yue, L., Zhang, W., Wang, Y., Wen, B., Zhong, L., Xiang, J., Li, J., Zhang, S., Wang, H., et al. Improvement in mouse iPSC induction by Rab32 reveals the importance of lipid metabolism during reprogramming. Sci Rep, 5, 2015, 16539 The authors describe upregulation of lipid biosynthesis during iPSC reprogramming mediated by Oct4, Sox2, Klf4, and Rab32. Inhibition of lipid biosynthesis reduced the reprogramming efficiency highlighting the importance of lipid metabolism during reprogramming.
-
(2015)
Sci Rep
, vol.5
, pp. 16539
-
-
Pei, Y.1
Yue, L.2
Zhang, W.3
Wang, Y.4
Wen, B.5
Zhong, L.6
Xiang, J.7
Li, J.8
Zhang, S.9
Wang, H.10
-
18
-
-
84872160110
-
Influence of threonine metabolism on S-adenosylmethionine and histone methylation
-
18 Shyh-Chang, N., Locasale, J.W., Lyssiotis, C.A., Zheng, Y., Teo, R.Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J.J., Zhu, H., et al. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 339 (2013), 222–226.
-
(2013)
Science
, vol.339
, pp. 222-226
-
-
Shyh-Chang, N.1
Locasale, J.W.2
Lyssiotis, C.A.3
Zheng, Y.4
Teo, R.Y.5
Ratanasirintrawoot, S.6
Zhang, J.7
Onder, T.8
Unternaehrer, J.J.9
Zhu, H.10
-
19
-
-
67749140110
-
Dependence of mouse embryonic stem cells on threonine catabolism
-
19 Wang, J., Alexander, P., Wu, L., Hammer, R., Cleaver, O., McKnight, S.L., Dependence of mouse embryonic stem cells on threonine catabolism. Science 325 (2009), 435–439.
-
(2009)
Science
, vol.325
, pp. 435-439
-
-
Wang, J.1
Alexander, P.2
Wu, L.3
Hammer, R.4
Cleaver, O.5
McKnight, S.L.6
-
20
-
-
84925503908
-
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
-
This study shows that manipulation of intracellular abundances can regulate the switch between self-renewal or differentiation in mouse ESCs. This is the first study to identify the regulation of Tet-dependent DNA demethylation by intracellular α-KG to succinate ratio.
-
20•• Carey, B.W., Finley, L.W.S., Cross, J.R., Allis, C.D., Thompson, C.B., Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518 (2014), 413–416 This study shows that manipulation of intracellular abundances can regulate the switch between self-renewal or differentiation in mouse ESCs. This is the first study to identify the regulation of Tet-dependent DNA demethylation by intracellular α-KG to succinate ratio.
-
(2014)
Nature
, vol.518
, pp. 413-416
-
-
Carey, B.W.1
Finley, L.W.S.2
Cross, J.R.3
Allis, C.D.4
Thompson, C.B.5
-
21
-
-
84879083630
-
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
-
21 Ulanovskaya, O.A., Zuhl, A.M., Cravatt, B.F., NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol 9 (2013), 300–306.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 300-306
-
-
Ulanovskaya, O.A.1
Zuhl, A.M.2
Cravatt, B.F.3
-
22
-
-
84904872156
-
The growing landscape of lysine acetylation links metabolism and cell signalling
-
22 Choudhary, C., Weinert, B.T., Nishida, Y., Verdin, E., Mann, M., The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol 15 (2014), 536–550.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 536-550
-
-
Choudhary, C.1
Weinert, B.T.2
Nishida, Y.3
Verdin, E.4
Mann, M.5
-
23
-
-
84930224849
-
Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes
-
This study exemplifies the potential of metabolic pathway induction of maturation in PSC-derived cell types. A switch from oxidative phosphorylation to fatty acid oxidation by overexpression of let-7 miRNAs resulted in maturation of hPSC-derived cardiomyocytes.
-
23•• Kuppusamy, K.T., Jones, D.C., Sperber, H., Madan, A., Fischer, K.a., Rodriguez, M.L., Pabon, L., Zhu, W.-Z., Tulloch, N.L., Yang, X., et al. Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes. Proc Natl Acad Sci, 2015, 10.1073/pnas.1424042112 This study exemplifies the potential of metabolic pathway induction of maturation in PSC-derived cell types. A switch from oxidative phosphorylation to fatty acid oxidation by overexpression of let-7 miRNAs resulted in maturation of hPSC-derived cardiomyocytes.
-
(2015)
Proc Natl Acad Sci
-
-
Kuppusamy, K.T.1
Jones, D.C.2
Sperber, H.3
Madan, A.4
Fischer, K.A.5
Rodriguez, M.L.6
Pabon, L.7
Zhu, W.-Z.8
Tulloch, N.L.9
Yang, X.10
-
24
-
-
84933181542
-
Microbial-derived lithocholic acid and vitamin K 2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes
-
Microbial metabolites can induce expression of CYP450 in hPSC-derived hepatocytes, improving their capacity to predict compound toxicity.
-
24• Avior, Y., Levy, G., Zimerman, M., Kitsberg, D., Schwartz, R., Sadeh, R., Moussaieff, A., Cohen, M., Itskovitz-Eldor, J., Nahmias, Y., Microbial-derived lithocholic acid and vitamin K 2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes. Hepatology 62 (2015), 265–278 Microbial metabolites can induce expression of CYP450 in hPSC-derived hepatocytes, improving their capacity to predict compound toxicity.
-
(2015)
Hepatology
, vol.62
, pp. 265-278
-
-
Avior, Y.1
Levy, G.2
Zimerman, M.3
Kitsberg, D.4
Schwartz, R.5
Sadeh, R.6
Moussaieff, A.7
Cohen, M.8
Itskovitz-Eldor, J.9
Nahmias, Y.10
-
25
-
-
84876570848
-
Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes
-
25 Robertson, C., Tran, D.D., George, S.C., Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes. Stem Cells 31 (2013), 829–837.
-
(2013)
Stem Cells
, vol.31
, pp. 829-837
-
-
Robertson, C.1
Tran, D.D.2
George, S.C.3
-
26
-
-
84887152893
-
Accurate prediction of drug-induced liver injury using stem cell-derived populations
-
26 Szkolnicka, D., Farnworth, S.L., Lucendo-Villarin, B., Storck, C., Zhou, W., Iredale, J.P., Flint, O., Hay, D.C., Accurate prediction of drug-induced liver injury using stem cell-derived populations. Stem Cells Transl Med 3 (2014), 141–148.
-
(2014)
Stem Cells Transl Med
, vol.3
, pp. 141-148
-
-
Szkolnicka, D.1
Farnworth, S.L.2
Lucendo-Villarin, B.3
Storck, C.4
Zhou, W.5
Iredale, J.P.6
Flint, O.7
Hay, D.C.8
-
27
-
-
84873332657
-
Production of hepatocyte-like cells from human pluripotent stem cells
-
27 Hannan, N.R.F., Segeritz, C.-P., Touboul, T., Vallier, L., Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc 8 (2013), 430–437.
-
(2013)
Nat Protoc
, vol.8
, pp. 430-437
-
-
Hannan, N.R.F.1
Segeritz, C.-P.2
Touboul, T.3
Vallier, L.4
-
28
-
-
79959221064
-
Energy metabolism in human pluripotent stem cells and their differentiated counterparts
-
28 Varum, S., Rodrigues, A.S., Moura, M.B., Momcilovic, O., Easley, C.A., Ramalho-Santos, J., Van Houten, B., Schatten, G., Energy metabolism in human pluripotent stem cells and their differentiated counterparts. PLoS One, 6, 2011, e20914.
-
(2011)
PLoS One
, vol.6
, pp. e20914
-
-
Varum, S.1
Rodrigues, A.S.2
Moura, M.B.3
Momcilovic, O.4
Easley, C.A.5
Ramalho-Santos, J.6
Van Houten, B.7
Schatten, G.8
-
29
-
-
84863111875
-
Human embryonic stem cells and embryonal carcinoma cells have overlapping and distinct metabolic signatures
-
29 Abu Dawud, R., Schreiber, K., Schomburg, D., Adjaye, J., Human embryonic stem cells and embryonal carcinoma cells have overlapping and distinct metabolic signatures. PLoS One, 7, 2012, e39896.
-
(2012)
PLoS One
, vol.7
, pp. e39896
-
-
Abu Dawud, R.1
Schreiber, K.2
Schomburg, D.3
Adjaye, J.4
-
30
-
-
84867487610
-
Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism
-
30 Meissen, J.K., Yuen, B.T.K., Kind, T., Riggs, J.W., Barupal, D.K., Knoepfler, P.S., Fiehn, O., Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism. PLoS One 7 (2012), 1–9.
-
(2012)
PLoS One
, vol.7
, pp. 1-9
-
-
Meissen, J.K.1
Yuen, B.T.K.2
Kind, T.3
Riggs, J.W.4
Barupal, D.K.5
Knoepfler, P.S.6
Fiehn, O.7
-
31
-
-
77958569435
-
Induced pluripotency: history, mechanisms, and applications
-
31 Stadtfeld, M., Hochedlinger, K., Induced pluripotency: history, mechanisms, and applications. Genes Dev 24 (2010), 2239–2263.
-
(2010)
Genes Dev
, vol.24
, pp. 2239-2263
-
-
Stadtfeld, M.1
Hochedlinger, K.2
-
32
-
-
84938743523
-
Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells
-
32 Patsch, C., Challet-Meylan, L., Thoma, E.C., Urich, E., Heckel, T., O'Sullivan, J.F., Grainger, S.J., Kapp, F.G., Sun, L., Christensen, K., et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol 17 (2015), 994–1003.
-
(2015)
Nat Cell Biol
, vol.17
, pp. 994-1003
-
-
Patsch, C.1
Challet-Meylan, L.2
Thoma, E.C.3
Urich, E.4
Heckel, T.5
O'Sullivan, J.F.6
Grainger, S.J.7
Kapp, F.G.8
Sun, L.9
Christensen, K.10
-
33
-
-
84872048038
-
Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes
-
The authors identified the ability of cardiomyocytes to utilize lactate in absence of glucose which allowed them to purify cardiomyocytes by exposing them to lactate rich and glucose free medium.
-
33• Tohyama, S., Hattori, F., Sano, M., Hishiki, T., Nagahata, Y., Matsuura, T., Hashimoto, H., Suzuki, T., Yamashita, H., Satoh, Y., et al. Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell 12 (2013), 127–137 The authors identified the ability of cardiomyocytes to utilize lactate in absence of glucose which allowed them to purify cardiomyocytes by exposing them to lactate rich and glucose free medium.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 127-137
-
-
Tohyama, S.1
Hattori, F.2
Sano, M.3
Hishiki, T.4
Nagahata, Y.5
Matsuura, T.6
Hashimoto, H.7
Suzuki, T.8
Yamashita, H.9
Satoh, Y.10
-
34
-
-
36048970985
-
Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain
-
34 Manganas, L.N., Zhang, X., Li, Y., Hazel, R.D., Smith, S.D., Wagshul, M.E., Henn, F., Benveniste, H., Djuric, P.M., Enikolopov, G., Maletić-Savatić, M., Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science 318 (2007), 980–985.
-
(2007)
Science
, vol.318
, pp. 980-985
-
-
Manganas, L.N.1
Zhang, X.2
Li, Y.3
Hazel, R.D.4
Smith, S.D.5
Wagshul, M.E.6
Henn, F.7
Benveniste, H.8
Djuric, P.M.9
Enikolopov, G.10
Maletić-Savatić, M.11
-
35
-
-
84868582029
-
Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient
-
35 Paulsen, B.d.S., Maciel, R.d.M., Galina, A., da Silveira, M.S., Souza, C.d.S., Drummond, H., Pozzatto, E.N., Junior, H.S., Chicaybam, L., Massuda, R., et al. Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient. Cell Transplant 21 (2012), 1547–1559.
-
(2012)
Cell Transplant
, vol.21
, pp. 1547-1559
-
-
Paulsen, B.D.S.1
Maciel, R.D.M.2
Galina, A.3
da Silveira, M.S.4
Souza, C.D.S.5
Drummond, H.6
Pozzatto, E.N.7
Junior, H.S.8
Chicaybam, L.9
Massuda, R.10
-
36
-
-
84867031150
-
Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue
-
36 Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., et al. Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain, 5, 2012, 35.
-
(2012)
Mol Brain
, vol.5
, pp. 35
-
-
Imaizumi, Y.1
Okada, Y.2
Akamatsu, W.3
Koike, M.4
Kuzumaki, N.5
Hayakawa, H.6
Nihira, T.7
Kobayashi, T.8
Ohyama, M.9
Sato, S.10
-
37
-
-
84863584524
-
Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease
-
141ra90
-
37 Cooper, O., Seo, H., Andrabi, S., Guardia-Laguarta, C., Graziotto, J., Sundberg, M., McLean, J.R., Carrillo-Reid, L., Xie, Z., Osborn, T., et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med, 4, 2012 141ra90.
-
(2012)
Sci Transl Med
, vol.4
-
-
Cooper, O.1
Seo, H.2
Andrabi, S.3
Guardia-Laguarta, C.4
Graziotto, J.5
Sundberg, M.6
McLean, J.R.7
Carrillo-Reid, L.8
Xie, Z.9
Osborn, T.10
-
38
-
-
81255159025
-
Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics
-
38 Kleinstreuer, N.C., Smith, A.M., West, P.R., Conard, K.R., Fontaine, B.R., Weir-Hauptman, A.M., Palmer, J.A., Knudsen, T.B., Dix, D.J., Donley, E.L.R., et al. Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics. Toxicol Appl Pharmacol 257 (2011), 111–121.
-
(2011)
Toxicol Appl Pharmacol
, vol.257
, pp. 111-121
-
-
Kleinstreuer, N.C.1
Smith, A.M.2
West, P.R.3
Conard, K.R.4
Fontaine, B.R.5
Weir-Hauptman, A.M.6
Palmer, J.A.7
Knudsen, T.B.8
Dix, D.J.9
Donley, E.L.R.10
-
39
-
-
84865765855
-
Metabolomic response of human embryonic stem cell-derived germ-like cells after exposure to steroid hormones
-
39 West, F.D., Henderson, W.M., Yu, P., Yang, J.Y., Stice, S.L., Smith, M.a., Metabolomic response of human embryonic stem cell-derived germ-like cells after exposure to steroid hormones. Toxicol Sci 129 (2012), 9–20.
-
(2012)
Toxicol Sci
, vol.129
, pp. 9-20
-
-
West, F.D.1
Henderson, W.M.2
Yu, P.3
Yang, J.Y.4
Stice, S.L.5
Smith, M.A.6
-
40
-
-
84885699761
-
Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells
-
40 von Stechow, L., Ruiz-Aracama, A., van de Water, B., Peijnenburg, A., Danen, E., Lommen, A., Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells. PLOS ONE, 8, 2013, e76476.
-
(2013)
PLOS ONE
, vol.8
, pp. e76476
-
-
von Stechow, L.1
Ruiz-Aracama, A.2
van de Water, B.3
Peijnenburg, A.4
Danen, E.5
Lommen, A.6
-
41
-
-
84864551960
-
Metabolic biomarkers of prenatal alcohol exposure in human embryonic stem cell-derived neural lineages
-
41 Palmer, J.A., Poenitzsch, A.M., Smith, S.M., Conard, K.R., West, P.R., Cezar, G.G., Metabolic biomarkers of prenatal alcohol exposure in human embryonic stem cell-derived neural lineages. Alcohol Clin Exp Res 36 (2012), 1314–1324.
-
(2012)
Alcohol Clin Exp Res
, vol.36
, pp. 1314-1324
-
-
Palmer, J.A.1
Poenitzsch, A.M.2
Smith, S.M.3
Conard, K.R.4
West, P.R.5
Cezar, G.G.6
-
42
-
-
79951775910
-
Characterisation of human embryonic stem cells conditioning media by 1H-nuclear magnetic resonance spectroscopy
-
42 MacIntyre, D.a., Melguizo Sanchís, D., Jiménez, B., Moreno, R., Stojkovic, M., Pineda-Lucena, A., Characterisation of human embryonic stem cells conditioning media by 1H-nuclear magnetic resonance spectroscopy. PLoS One, 6, 2011, e16732.
-
(2011)
PLoS One
, vol.6
, pp. e16732
-
-
MacIntyre, D.A.1
Melguizo Sanchís, D.2
Jiménez, B.3
Moreno, R.4
Stojkovic, M.5
Pineda-Lucena, A.6
-
43
-
-
84979734807
-
Distinct metabolic states can support self-renewal and lipogenesis in human pluripotent stem cells under different culture conditions
-
hESCs possess the ability to rewire metabolic pathways depending on the nutrient availability. Lipid-depleted medium upregulated lipid biosynthesis and redox pathways and downregulated oxidative phosphorylation.
-
43•• Zhang, H., Badur, M.G., Divakaruni, A.S., Parker, S.J., Jäger, C., Hiller, K., Murphy, A.N., Metallo, C.M., Distinct metabolic states can support self-renewal and lipogenesis in human pluripotent stem cells under different culture conditions. Cell Rep 16 (2016), 1–12 hESCs possess the ability to rewire metabolic pathways depending on the nutrient availability. Lipid-depleted medium upregulated lipid biosynthesis and redox pathways and downregulated oxidative phosphorylation.
-
(2016)
Cell Rep
, vol.16
, pp. 1-12
-
-
Zhang, H.1
Badur, M.G.2
Divakaruni, A.S.3
Parker, S.J.4
Jäger, C.5
Hiller, K.6
Murphy, A.N.7
Metallo, C.M.8
-
44
-
-
84913537162
-
Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations
-
44 Turner, J., Quek, L.-E., Titmarsh, D., Krömer, J.O., Kao, L.-P., Nielsen, L., Wolvetang, E., Cooper-White, J., Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations. PLOS ONE, 9, 2014, e112757.
-
(2014)
PLOS ONE
, vol.9
, pp. e112757
-
-
Turner, J.1
Quek, L.-E.2
Titmarsh, D.3
Krömer, J.O.4
Kao, L.-P.5
Nielsen, L.6
Wolvetang, E.7
Cooper-White, J.8
-
45
-
-
84877090090
-
Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells
-
The authors showed significant changes occur due to enzymatic passaging in hESCs, specifically in glucose metabolism, lipid biosynthesis and abundance of glycan moieties.
-
45• Forristal, C.E., Christensen, D.R., Chinnery, F.E., Petruzzelli, R., Parry, K.L., Sanchez-Elsner, T., Houghton, F.D., Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells. PLOS ONE, 8, 2013, e62507 The authors showed significant changes occur due to enzymatic passaging in hESCs, specifically in glucose metabolism, lipid biosynthesis and abundance of glycan moieties.
-
(2013)
PLOS ONE
, vol.8
, pp. e62507
-
-
Forristal, C.E.1
Christensen, D.R.2
Chinnery, F.E.3
Petruzzelli, R.4
Parry, K.L.5
Sanchez-Elsner, T.6
Houghton, F.D.7
-
46
-
-
84859887586
-
Effects of 3D microwell culture on growth kinetics and metabolism of human embryonic stem cells
-
46 Azarin, S.M., Larson, E.A., Almodóvar-Cruz, J.M., de Pablo, J.J., Palecek, S.P., Effects of 3D microwell culture on growth kinetics and metabolism of human embryonic stem cells. Biotechnol Appl Biochem 59 (2012), 88–96.
-
(2012)
Biotechnol Appl Biochem
, vol.59
, pp. 88-96
-
-
Azarin, S.M.1
Larson, E.A.2
Almodóvar-Cruz, J.M.3
de Pablo, J.J.4
Palecek, S.P.5
-
47
-
-
84943362832
-
Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance
-
47 Badur, M.G., Zhang, H., Metallo, C.M., Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance. Biotechnol J 10 (2015), 1600–1611.
-
(2015)
Biotechnol J
, vol.10
, pp. 1600-1611
-
-
Badur, M.G.1
Zhang, H.2
Metallo, C.M.3
-
48
-
-
33748792541
-
3-D microwell culture of human embryonic stem cells
-
48 Mohr, J.C., de Pablo, J.J., Palecek, S.P., 3-D microwell culture of human embryonic stem cells. Biomaterials 27 (2006), 6032–6042.
-
(2006)
Biomaterials
, vol.27
, pp. 6032-6042
-
-
Mohr, J.C.1
de Pablo, J.J.2
Palecek, S.P.3
-
49
-
-
84856007232
-
The promise of induced pluripotent stem cells in research and therapy
-
49 Robinton, D.A., Daley, G.Q., The promise of induced pluripotent stem cells in research and therapy. Nature 481 (2012), 295–305.
-
(2012)
Nature
, vol.481
, pp. 295-305
-
-
Robinton, D.A.1
Daley, G.Q.2
-
50
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for genome engineering
-
50 Hsu, P.D., Lander, E.S., Zhang, F., Development and applications of CRISPR-Cas9 for genome engineering. Cell 157 (2014), 1262–1278.
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
-
51
-
-
84905921360
-
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification
-
51 Oburoglu, L., Tardito, S., Fritz, V., de Barros, S.C., Merida, P., Craveiro, M., Mamede, J., Cretenet, G., Mongellaz, C., An, X., et al. Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification. Cell Stem Cell 15 (2014), 169–184.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 169-184
-
-
Oburoglu, L.1
Tardito, S.2
Fritz, V.3
de Barros, S.C.4
Merida, P.5
Craveiro, M.6
Mamede, J.7
Cretenet, G.8
Mongellaz, C.9
An, X.10
-
52
-
-
24944444149
-
Summary recommendations for standardization and reporting of metabolic analyses
-
52 Lindon, J.C., Nicholson, J.K., Holmes, E., Keun, H.C., Craig, A., Pearce, J.T.M., Bruce, S.J., Hardy, N., Sansone, S.-A., Antti, H., et al. Summary recommendations for standardization and reporting of metabolic analyses. Nat Biotechnol 23 (2005), 833–838.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 833-838
-
-
Lindon, J.C.1
Nicholson, J.K.2
Holmes, E.3
Keun, H.C.4
Craig, A.5
Pearce, J.T.M.6
Bruce, S.J.7
Hardy, N.8
Sansone, S.-A.9
Antti, H.10
|