Histone deacetylase 1 deficiency impairs differentiation and electrophysiological properties of cardiomyocytes derived from induced pluripotent cells

Stem Cells

Volumn 30, Issue 11, 2012, Pages 2412-2422

  Hoxha, Eneda ^a   Lambers, Erin ^a   Xie, Hehuang ^b   De Andrade, Alexandre ^b   Krishnamurthy, Prasanna ^a   Wasserstrom, John A ^a   Ramirez, Veronica ^a   Thal, Melissa ^a   Verma, Suresh K ^a   Soares, Marcelo B ^b   Kishore, Raj ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Children's Memorial Research Center   (United States)

Author keywords

Cardiovascular differentiation; Epigenetic regulation; Histone deacetylase 1; Histone deacetylases; Induced pluripotent stem cells; Stem cells

Indexed keywords

HISTONE DEACETYLASE 1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; DNA METHYLATION; ELECTROPHYSIOLOGY; EMBRYONIC STEM CELL; ENZYME DEFICIENCY; HEART MUSCLE CELL; NONHUMAN; PLURIPOTENT STEM CELL;

ANIMALS; CALCIUM SIGNALING; CELL DIFFERENTIATION; CONNEXIN 43; DNA METHYLATION; EMBRYOID BODIES; EPIGENESIS, GENETIC; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASE 1; HISTONES; HOMEODOMAIN PROTEINS; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; NIH 3T3 CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; SEQUENCE ANALYSIS, DNA; SOXB1 TRANSCRIPTION FACTORS; TROPONIN T;

EID: 84867905127     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1209     Document Type: Article

References (25)

1. Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872. (Pubitemid 350138099)
2. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676. (Pubitemid 44233629)
3. Rolletschek A, Wobus AM. Induced human pluripotent stem cells: Promises and open questions. Biol Chem 2009;390:845-849.
4. Stefanovic S, Abboud N, Desilets S et al. Interplay of Oct4 with Sox2 and Sox17: A molecular switch from stem cell pluripotency to specifying a cardiac fate. J Cell Biol 2009;186:665-673.
5. Wang J, Rao S, Chu J et al. A protein interaction network for pluripotency of embryonic stem cells. Nature 2006;444:364-368. (Pubitemid 44764111)
6. Xi S, Geiman TM, Briones V et al. Lsh participates in DNA methylation and silencing of stem cell genes. Stem Cells 2009;27:2691-2702.
7. Chen X, Xu H, Yuan P et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008;133:1106-1117. (Pubitemid 351787745)
8. Bernstein BE, Mikkelsen TS, Xie X et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006;125:315-326.
9. Dovey OM, Foster CT, Cowley SM. Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation. Proc Natl Acad Sci USA 2010;107:8242-8247.
10. Holliday R. Epigenetics: A historical overview. Epigenetics 2006;1:76-80.
11. Hu Q, Friedrich AM, Johnson LV et al. Memory in induced pluripotent stem cells: Reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells 2010;28:1981-1991.
12. Karantzali E, Schulz H, Hummel O et al. Histone deacetylase inhibition accelerates the early events of stem cell differentiation: Transcriptomic and epigenetic analysis. Genome Biol 2008;9:R65.
13. Lee TI, Jenner RG, Boyer LA et al. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 2006;125:301-313. (Pubitemid 44313811)
14. Kim K, Doi A, Wen B et al. Epigenetic memory in induced pluripotent stem cells. Nature 2010;467:285-290.
15. Rajasingh J, Lambers E, Hamada H et al. Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair. Circ Res 2008;102:e107-117.
16. Wasserstrom JA, Sharma R, Kapur S et al. Multiple defects in intracellular calcium cycling in whole failing rat heart. Circulation 2009;2:223-232.
17. Xie H, Wang M, Bonaldo Mde F et al. High-throughput sequence-based epigenomic analysis of Alu repeats in human cerebellum. Nucleic Acids Res 2009;37:4331-4340.
18. Ma P, Schultz RM. Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. Dev Biol 2008;319:110-120.
19. Montgomery RL, Davis CA, Potthoff MJ et al. Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev 2007;21:1790-1802. (Pubitemid 47076478)
20. Liang J, Wan M, Zhang Y et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol 2008;10:731-739. (Pubitemid 351772939)
21. Marmorstein R. Protein modules that manipulate histone tails for chromatin regulation. Nat Rev Mol Cell Biol 2001;2:422-432. (Pubitemid 33680581)
22. Mikkelsen TS, Ku M, Jaffe DB et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007;448:553-560. (Pubitemid 47206934)
23. Xue Y, Wong J, Moreno GT et al. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 1998;2:851-861. (Pubitemid 128378992)
24. Lee JH, Hart SR, Skalnik DG. Histone deacetylase activity is required for embryonic stem cell differentiation. Genesis 2004;38:32-38. (Pubitemid 38197607)
25. Lagger S, Meunier D, Mikula M et al. Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans. EMBO J 2010;29:3992-4007.