Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction

Human Gene Therapy

Volumn 21, Issue 10, 2010, Pages 1327-1334

  Sen, Sabyasachi ^a   Merchan, Juan ^a   Dean, Jarrod ^a   Ii, Masaaki ^a   Gavin, Mary ^a   Silver, Marcy ^a   Tkebuchava, Tengiz ^a   Yoon, Young Sup ^a   Rasko, John E J ^b,c   Aikawa, Ryuichi ^a,c  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GENISTEIN; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; ECHOCARDIOGRAPHY; GENE THERAPY; HEART INFARCTION; HEART MUSCLE CELL; HISTOPATHOLOGY; MALE; NONHUMAN; RAT;

ANIMALS; APOPTOSIS; CAPILLARIES; CORONARY VESSELS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; ENDOTHELIAL CELLS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GENISTEIN; HEART FUNCTION TESTS; INSULIN-LIKE GROWTH FACTOR I; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; STEM CELL TRANSPLANTATION; STEM CELLS; TRANSDUCTION, GENETIC; TRANSPLANTATION, AUTOLOGOUS;

ADENO-ASSOCIATED VIRUS; RATTUS;

EID: 77958108352     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2010.006     Document Type: Article

References (37)

1. Aikawa, R., Nawano, M., Gu, Y., Katagiri, H., Asano, T., Zhu, W., Nagai, R., and Komuro, I. (2000). Insulin prevents cardi-omyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation 102, 2873-2879.
2. Aikawa, R., Huggins, G.S., and Snyder, R.O. (2002). Cardio-myocyte- specific gene expression following recombinant adeno-associated viral vector transduction. J. Biol. Chem. 277, 18979-18985.
3. Aiuti, A., Bachoud-Lévi, A.C., Blesch, A., Brenner, M.K., Catta-neo, F., Chiocca, E.A., Gao, G., High, K.A., Leen, A.M., Le-moine, N.R., McNeish, I.A., Meneguzzi, G., Peschanski, M., Roncarolo, M.G., Strayer, D.S., Tuszynski, M.H., Waxman, D.J., and Wilson, J.M. (2007). Progress and prospects: gene therapy clinical trials (part 2). Gene Ther. 14, 1555-1563.
4. Chng, K., Larsen, S.R., Zhou, S., Wright, J.F., Martiniello-Wilks, R., and Rasko, J.E.J. (2007). Specific adeno-associated virus sero-types facilitate efficient gene transfer into human and non-human primate mesenchymal stromal cells. J. Gene Med. 9, 22-32.
5. Delafontaine, P., Song, Y.H., and Li, Y. (2004). Expression, reg-ulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler. Thromb. Vasc. Biol. 24, 435-444.
6. Ding, W., Yan, Z., Zak, R., Saavedra, M., Rodman, D.M., and Engelhardt, J.F. (2003). Second-strand genome conversion of adeno-associated virus type 2 (AAV-2) and AAV-5 is not rate limiting following apical infection of polarized human airway epithelia. J. Virol. 77, 7361-7366.
7. Dobrucki, L.W., Tsutsumi, Y., Kalinowski, L., Dean, J., Gavin, M., Sen, S., Mendizabal, M., Sinusas, A.J., and Aikawa, R. (2010). Analysis of angiogenesis induced by local IGF-1 ex-pression after myocardial infarction using microSPECT-CT imaging. J. Mol. Cell. Cardiol. 48, 1071-1079.
8. Inagaki, K., Fuess, S., Storm, T.A., Gibson, G.A., McTiernan, C.F., Kay, M.A., and Nakai, H. (2006). Robust systemic transduction with AAV9 vectors in mice: Efficient global car-diac gene transfer superior to that of AAV8. Mol. Ther. 14,45-53.
9. Iwakura, A., Dean, J., Hamada, H., Eaton, E., Qin, G., Losordo, D.W., and Aikawa, R. (2005). Use of recombinant adeno-as-sociated viral vectors as a tool for labeling bone marrow cells. J. Mol. Cell. Cardiol. 38, 799-802.
10. Kawamoto, A., Gwon, H.C., Iwaguro, H., Yamaguchi, J.I., Uchida, S., Masuda, H., Silver, M., Ma, H., Kearney, M., Isner, J.M., and Asahara, T. (2001). Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ische-mia. Circulation 103, 634-637.
11. Kawamoto A., Tkebuchava T., Yamaguchi J., Nishimura H., Yoon Y.S., Milliken C., Uchida S., Masuo O., Iwaguro H., Ma H., Hanley A., Silver M., Kearney M., Losordo D.W., Isner J.M., and Asahara T. (2003). Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation 107, 461-468.
12. Khan, A.S., Sane, D.C., Wannenburg, T., and Sonntag, W.E. (2002). Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovasc. Res. 54, 25-35.
13. Kusano, K., Tsutsumi, Y., Dean, J., Gavin, M., Ma, H., Silver, M., Thorne, T., Zhu, Y., Losordo, D.W., and Aikawa, R. (2007). Long-term stable expression of human growth hormone by rAAV promotes myocardial protection post-myocardial in-farction. J. Mol. Cell. Cardiol. 42, 390-399.
14. Laviola, L., Natalicchio, A., and Giorgino, F. (2007). The IGF-I signaling pathway. Curr. Pharm. Des. 13, 663-669.
15. Li, Q., Li, B., Wang, X., Leri, A., Jana, K.P., Liu, Y., Kajstura, J., Baserga, R., and Anversa, P. (1997). Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J. Clin. Invest. 100, 1991-1999.
16. Liu, J.L., and Leroith, D. (1999). Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Endocrinology 140, 5178-5184.
17. Liu, X., Pachori, A.S., Ward, C.A., Davis, J.P., Gnecchi, M., Kong, D., Zhang, L., Murduck, J., Yet, S.F., Perrella, M.A., Pratt, R.E., Dzau, V.J., and Melo, L.G. (2006). Heme oxygenase-1 (HO-1) inhibits postmyocardial infarct remodeling and restores ven-tricular function. FASEB J. 20, 207-216.
18. Lopez-Lopez, C., Leroith, D., and Torres-Aleman, I. (2004). In-sulin-like growth factor I is required for vessel remodeling in the adult brain. Proc. Natl. Acad. Sci. U.S.A. 101, 9833-9838.
19. + stem cells for intractable angina: A phase I/IIa double-blind, random-ized controlled trial. Circulation 115, 3165-3172.
20. Manno, C.S., Pierce, G.F., Arruda, V.R., Glader, B., Ragni, M., Rasko, J.J., Ozelo, M.C., Hoots, K., Blatt, P., Konkle, B., Dake, M., Kaye, R., Razavi, M., Zajko, A., Zehnder, J., Rustagi, P.K., Nakai, H., Chew, A., Leonard, D., Wright, J.F., Lessard, R.R., Sommer, J.M., Tigges, M., Sabatino, D., Luk, A., Jiang, H., Mingozzi, F., Couto, L., Ertl, H.C., High, K.A., and Kay, M.A. (2006). Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune re-sponse. Nat. Med. 12, 342-347.
21. Nakai, H., Storm, T.A., and Kay, M.A. (2000). Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo. J. Virol. 74, 9451-9463.
22. Okada, T., Uchibori, R., Iwata-Okada, M., Takahashi, M., Nomoto, T., Nonaka-Sarukawa, M., Ito, T., Liu, Y., Mizukami, H., Kume, A., Kobayashi, E., and Ozawa, K. (2006). A histone deacetylase inhibitor enhances recombinant adeno-associated virus-mediated gene expression in tumor cells. Mol. Ther. 13, 738-746.
23. Pajusola, K., Gruchala, M., Joch, H., Luscher, T.F., Yla-Herttuala, S., and Bueler, H. (2002). Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells. J. Virol. 76, 11530-11540.
24. Qing, K., Khuntirat, B., Mah, C., Kube, D.M., Wang, X.S., Pon-nazhagan, S., Zhou, S., Dwarki, V.J., Yoder, M.C., and Sri-vastava, A. (1998). Adeno-associated virus type 2-mediated gene transfer: correlation of tyrosine phosphorylation of the cellular single-stranded D sequence-binding protein with transgene expression in human cells in vitro and murine tis-sues in vivo. J. Virol. 72, 1593-1599.
25. Qing, K., Hansen, J., Weigel-Kelley, K.A., Tan, M., Zhou, S., and Srivastava, A. (2001). Adeno-associated virus type 2-mediated gene transfer: role of cellular FKBP52 protein in transgene expression. J. Virol. 75, 8968-8976.
26. Rabinovsky, E.D., and Draghia-Akli, R. (2004). Insulin-like growth factor I plasmid therapy promotes in vivo angiogene-sis. Mol. Ther. 9, 46-45.
27. Schulze, P.C., Fang, J., Kassik, K.A., Gannon, J., Cupesi, M., Macgillivray, C., Lee, R.T., and Rosenthal, N. (2005). Trans-genic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Circ. Res. 97, 418-426.
28. Su, E.J., Cioffi, C.L., Stefansson, S., Mittereder, N., Garay, M., Hreniuk, D., and Liau, G. (2003). Gene therapy vector-mediated expression of insulin-like growth factors protects cardiomyocytes from apoptosis and enhances neovascular-ization. Am. J. Physiol. Heart Circ. Physiol. 284, H1429-H1440.
29. Thum, T., Hoeber, S., Froese, S., Klink, I., Stichtenoth, D.O., Galuppo, P., Jakob, M., Tsikas, D., Anker, S.D., Poole-Wilson, P.A., Borlak, J., Ertl, G., and Bauersachs, J. (2007). Age-dependent impairment of endothelial progenitor cells is cor-rected by growth-hormone-mediated increase of insulin-like growth-factor-1. Circ. Res. 100, 434-443.
30. Torella, D., Rota, M., Nurzynska, D., Musso, E., Monsen, A., Shiraishi, I., Zias, E., Walsh, K., Rosenzweig, A., Sussman, M.A., Urbanek, K., Nadal-Ginard, B., Kajstura, J., Anversa, P., and Leri, A. (2004). Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ. Res. 94, 514-524.
31. Van Vliet, K.M., Blouin, V., Brument, N., Agbandje-McKenna, M., and Snyder, R.O. (2008). The role of the adeno-associated virus capsid in gene transfer. Methods Mol. Biol. 437, 51-91.
32. Vincent-Lacaze, N., Snyder, R.O., Gluzman, R., Bohl, D., Lagarde, C., and Danos, O. (1999). Structure of adeno-associated virus vector DNA following transduction of the skeletal muscle. J. Virol. 73, 1949-1955.
33. Vistica, D.T., Skehan, P., Scudiero, D., Monks, A., Pittman, A., and Boyd, M.R. (1991). Tetrazolium-based assays for cellular viability: A critical examination of selected parameters af-fecting formazan production. Cancer Res. 51, 4501.
34. Welch, S., Plank, D., Witt, S., Glascock, B., Schaefer, E., Chimenti, S., Andreoli, A.M., Limana, F., Leri, A., Kajstura, J., Anversa, P., and Sussman, M.A. (2002). Cardiac-specific IGF-1 expres-sion attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ. Res. 90, 641-648.
35. Wheeler, M.D., Kono, H., Rusyn, I., Arteel, G.E., McCarty, D., Samulski, R.J., and Thurman, R.G. (2000). Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFκB-dependent mechanisms. Hepa-tology 32, 1050-1059.
36. Yoon, Y.S., Wecker, A., Heyd, L., Park, J.S., Tkebuchava, T., Kusano, K., Hanley, A., Scadova, H., Qin, G., Cha, D.H., Johnson, K.L., Aikawa, R., Asahara, T., and Losordo, D.W. (2005). Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocar-dial infarction. J. Clin. Invest. 115, 326-338.
37. Zhong, L., Li, W., Yang, Z., Chen, L., Li, Y., Qing, K., Weigel-Kelley, K.A., Yoder, M.C., Shou, W., and Srivastava, A. (2004). Improved transduction of primary murine hepatocytes by recombinant adeno-associated virus 2 vectors in vivo. Gene Ther. 11, 1165-1169