Long-term cultured mesenchymal stem cells frequently develop genomic mutations but do not undergo malignant transformation

Cell Death and Disease

Volumn 4, Issue 12, 2013, Pages

  Wang, Y ^a   Zhang, Z ^b   Chi, Y ^a   Zhang, Q ^b   Xu, F ^a   Yang, Z ^a   Meng, L ^a,c   Yang, S ^a   Yan, S ^d   Mao, A ^d   Zhang, J ^d   Yang, Y ^b   Wang, S ^b   Cui, J ^a   Liang, L ^d   Ji, Y ^a   Han, Z B ^a,c,d   Fang, X ^b   Han, Z C ^a,c,d  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b Chinese Academy of Sciences and China National Center for Bioinformation   (China)

^c INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^d AmCellGene Co Ltd   (China)

Author keywords

array based comparative genomic hybridization; copy number variations; mesenchymal stem cells; mRNA Seq

Indexed keywords

MESSENGER RNA; TELOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL CLONING; CELL CYCLE REGULATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; GENE MUTATION; GENOMIC INSTABILITY; GENOMICS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; KARYOTYPING; MALIGNANT TRANSFORMATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; TELOMERE; TRISOMY; UMBILICAL CORD; UPREGULATION;

CELLS, CULTURED; DNA COPY NUMBER VARIATIONS; HUMANS; KARYOTYPE; MESENCHYMAL STROMAL CELLS; MUTATION; PHYLOGENY; TELOMERE;

EID: 84891797874     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.480     Document Type: Article

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