Cardioprotective Effect of MicroRNA-21 in Murine Myocardial Infarction

Cardiovascular Therapeutics

Volumn 33, Issue 3, 2015, Pages 109-117

  Gu, Guo Long ^a   Xu, Xiao Lin ^b   Sun, Xiao Tian ^b,c   Zhang, Ji ^d   Guo, Chang Fa ^c   Wang, Chun Sheng ^c   Sun, Bing ^e   Guo, Gong Liang ^e   Ma, Ke ^e   Huang, Yuan Yuan ^e   Sun, Li Qun ^e   Wang, Yi Qing ^b  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b FUDAN UNIVERSITY   (China)

^c ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

^d TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^e TONGJI UNIVERSITY   (China)

Author keywords

Cardiac function; Cardioprotective effect; Cell apoptosis; MicroRNA 21; Myocardial infarction; Transfection

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CASPASE 3; COLLAGEN TYPE 1; FIBRONECTIN; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; MICRORNA 21; PROTEIN BAX; PROTEIN BCL 2; MICRORNA; MIRN21 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; GENE EXPRESSION; GENETIC TRANSFECTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LEFT VENTRICULAR FRACTIONAL SHORTENING; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; HEART FUNCTION TEST; HEART VENTRICLE; HEART VENTRICLE REMODELING; METABOLISM; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CASPASE 3; COLLAGEN TYPE I; FIBRONECTINS; HEART FUNCTION TESTS; HEART VENTRICLES; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; VENTRICULAR REMODELING;

EID: 84929172296     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/1755-5922.12118     Document Type: Article

References (35)

1. Fiedler J, Jazbutyte V, Kirchmaier BC, et al. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 2011;124:720-730.
2. Seeger FH, Zeiher AM, Dimmeler S. MicroRNAs in stem cell function and regenerative therapy of the heart. Arterioscler Thromb Vasc Biol 2013;33:1739-1746.
3. Qin Y, Yu Y, Dong H, Bian X, Guo X, Dong S. MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis. Int J Med Sci 2012;9:413-423.
4. Jneid H, Alam M, Virani SS, Bozkurt B. Redefining myocardial infarction: what is new in the ESC/ACCF/AHA/WHF Third Universal Definition of myocardial infarction? Methodist Debakey Cardiovasc J 2013;9:169-172.
5. Gianstefani S, Douiri A, Delithanasis I, et al. Incidence and predictors of early left ventricular thrombus after ST-elevation myocardial infarction in the contemporary era of primary percutaneous coronary intervention. Am J Cardiol 2014;113:1111-1116.
6. Rodrigo R, Libuy M, Feliu F, Hasson D. Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction. Biomed Res Int 2013;2013:437613.
7. Komosa A, Lesiak M, Siniawski A, Mularek-Kubzdela T, Grajek S. Significance of antiplatelet therapy in emergency myocardial infarction treatment. Postepy Kardiol Interwencyjnej 2014;10:32-39.
8. Shacham Y, Leshem-Rubinow E, Roth A. Is long-term beta-blocker therapy for myocardial infarction survivors still relevant in the era of primary percutaneous coronary intervention? Isr Med Assoc J 2013;15:770-774.
9. Christia P, Frangogiannis NG. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest 2013;43:986-995.
10. Mezzaroma E, Toldo S, Farkas D, et al. The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proc Natl Acad Sci USA 2011;108:19725-19730.
11. Scimia MC, Gumpert AM, Koch WJ. Cardiovascular gene therapy for myocardial infarction. Expert Opin Biol Ther 2014;14:183-195.
12. Condorelli G, Latronico MV, Dorn GW 2nd. microRNAs in heart disease: putative novel therapeutic targets? Eur Heart J 2010;31:649-658.
13. van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A 2008;105:13027-13032.
14. Ren XP, Wu J, Wang X, et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation 2009;119:2357-2366.
15. Wang J, Huang W, Xu R, et al. MicroRNA-24 regulates cardiac fibrosis after myocardial infarction. J Cell Mol Med 2012;16:2150-2160.
16. Caroli A, Cardillo MT, Galea R, Biasucci LM. Potential therapeutic role of microRNAs in ischemic heart disease. J Cardiol 2013;61:315-320.
17. Cheng Y, Zhang C. MicroRNA-21 in cardiovascular disease. J Cardiovasc Transl Res 2010;3:251-255.
18. Fan X, Wang E, Wang X, Cong X, Chen X. MicroRNA-21 is a unique signature associated with coronary plaque instability in humans by regulating matrix metalloproteinase-9 via reversion-inducing cysteine-rich protein with Kazal motifs. Exp Mol Pathol 2014;96:242-249.
19. National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the care and use of laboratory animals. 8th edition. Washington, DC: National Academies Press, 2011.
20. Raber L, Kelbaek H, Ostojic M, et al. Effect of biolimus-eluting stents with biodegradable polymer vs bare-metal stents on cardiovascular events among patients with acute myocardial infarction: the COMFORTABLE AMI randomized trial. JAMA 2012;308:777-787.
21. Dangas GD, Caixeta A, Mehran R, et al. Frequency and predictors of stent thrombosis after percutaneous coronary intervention in acute myocardial infarction. Circulation 2011;123:1745-1756.
22. Suh JW, Mehran R, Claessen BE, et al. Impact of in-hospital major bleeding on late clinical outcomes after primary percutaneous coronary intervention in acute myocardial infarction the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial. J Am Coll Cardiol 2011;58:1750-1756.
23. Li C, Nguyen HT, Zhuang Y, et al. Post-transcriptional up-regulation of miR-21 by type I collagen. Mol Carcinog 2011;50:563-570.
24. Zile MR, Mehurg SM, Arroyo JE, Stroud RE, DeSantis SM, Spinale FG. Relationship between the temporal profile of plasma microRNA and left ventricular remodeling in patients after myocardial infarction. Circ Cardiovasc Genet 2011;4:614-619.
25. Fiedler J, Thum T. MicroRNAs in myocardial infarction. Arterioscler Thromb Vasc Biol 2013;33:201-205.
26. Qian L, Van Laake LW, Huang Y, Liu S, Wendland MF, Srivastava D. miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes. J Exp Med 2011;208:549-560.
27. Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;456:980-984.
28. Liu G, Friggeri A, Yang Y, et al. miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010;207:1589-1597.
29. Chung AC, Dong Y, Yang W, Zhong X, Li R, Lan HY. Smad7 suppresses renal fibrosis via altering expression of TGF-beta/Smad3-regulated microRNAs. Mol Ther 2013;21:388-398.
30. Zarjou A, Yang S, Abraham E, Agarwal A, Liu G. Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol 2011;301:F793-F801.
31. Zhou L, McMahon C, Bhagat T, et al. Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Res 2011;71:955-963.
32. Knuuti E, Kauppila S, Kotila V, Risteli J, Nissi R. Genitourinary prolapse and joint hypermobility are associated with altered type I and III collagen metabolism. Arch Gynecol Obstet 2011;283:1081-1085.
33. Wu JJ, Weis MA, Kim LS, Eyre DR. Type III collagen, a fibril network modifier in articular cartilage. J Biol Chem 2010;285:18537-18544.
34. Zhao Y, Xu Y, Zhang J, Ji T. Cardioprotective effect of carvedilol: inhibition of apoptosis in H9c2 cardiomyocytes via the TLR4/NF-kappaB pathway following ischemia/reperfusion injury. Exp Ther Med 2014;8:1092-1096.
35. Fang J, Song XW, Tian J, et al. Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes. Apoptosis 2012;17:410-423.