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Volumn 8, Issue 28, 2017, Pages 45200-45212

Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis

Author keywords

Angiogenesis; Exosomes; Mesenchymal stem cells; miR 30b; miRNA transfer

Indexed keywords

MICRORNA; MICRORNA 30B; MICRORNA 30C; MICRORNA 424; MICRORNA LET 7F; UNCLASSIFIED DRUG;

EID: 85022226203     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16778     Document Type: Article
Times cited : (312)

References (56)
  • 1
    • 84945451527 scopus 로고    scopus 로고
    • Overexpression of Cardiomyocyte alpha1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling
    • Zhao X, Balaji P, Pachon R, Beniamen DM, Vatner DE, Graham RM, Vatner SF. Overexpression of Cardiomyocyte alpha1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling. Arterioscler Thromb Vasc Biol. 2015; 35:2451-9
    • (2015) Arterioscler Thromb Vasc Biol , vol.35 , pp. 2451-2459
    • Zhao, X.1    Balaji, P.2    Pachon, R.3    Beniamen, D.M.4    Vatner, D.E.5    Graham, R.M.6    Vatner, S.F.7
  • 3
    • 84881114106 scopus 로고    scopus 로고
    • Therapeutic angiogenesis for critical limb ischaemia
    • Annex BH. Therapeutic angiogenesis for critical limb ischaemia. Nat Rev Cardiol. 2013; 10:387-96
    • (2013) Nat Rev Cardiol , vol.10 , pp. 387-396
    • Annex, B.H.1
  • 4
    • 84867010030 scopus 로고    scopus 로고
    • Pro-angiogenic cell-based therapy for the treatment of ischemic cardiovascular diseases
    • Silvestre JS. Pro-angiogenic cell-based therapy for the treatment of ischemic cardiovascular diseases. Thromb Res. 2012; 130:S90-4
    • (2012) Thromb Res , vol.130 , pp. S90-S94
    • Silvestre, J.S.1
  • 5
    • 84943549550 scopus 로고    scopus 로고
    • Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium
    • Suresh SC, Selvaraju V, Thirunavukkarasu M, Goldman JW, Husain A, Alexander PJ, Sanchez JA, McFadden DW, Maulik N. Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium. Int J Cardiol. 2015; 201:517-28
    • (2015) Int J Cardiol , vol.201 , pp. 517-528
    • Suresh, S.C.1    Selvaraju, V.2    Thirunavukkarasu, M.3    Goldman, J.W.4    Husain, A.5    Alexander, P.J.6    Sanchez, J.A.7    McFadden, D.W.8    Maulik, N.9
  • 6
    • 33745356932 scopus 로고    scopus 로고
    • Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling
    • Uemura R, Xu M, Ahmad N, Ashraf M. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. 2006; 98:1414-21
    • (2006) Circ Res , vol.98 , pp. 1414-1421
    • Uemura, R.1    Xu, M.2    Ahmad, N.3    Ashraf, M.4
  • 7
    • 33846395496 scopus 로고    scopus 로고
    • In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function
    • Xu M, Uemura R, Dai Y, Wang Y, Pasha Z, Ashraf M. In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol. 2007; 42:441-8
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 441-448
    • Xu, M.1    Uemura, R.2    Dai, Y.3    Wang, Y.4    Pasha, Z.5    Ashraf, M.6
  • 9
    • 77956638921 scopus 로고    scopus 로고
    • A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke
    • Lee JS, Hong JM, Moon GJ, Lee PH, Ahn YH, Bang OY. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke. Stem Cells. 2010; 28:1099-106
    • (2010) Stem Cells , vol.28 , pp. 1099-1106
    • Lee, J.S.1    Hong, J.M.2    Moon, G.J.3    Lee, P.H.4    Ahn, Y.H.5    Bang, O.Y.6
  • 10
    • 39149088671 scopus 로고    scopus 로고
    • Prospects for stem cell-based therapy
    • Daley GQ, Scadden DT. Prospects for stem cell-based therapy. Cell. 2008; 132:544-8
    • (2008) Cell , vol.132 , pp. 544-548
    • Daley, G.Q.1    Scadden, D.T.2
  • 13
    • 84899545895 scopus 로고    scopus 로고
    • Dynamic induction of pro-angiogenic milieu after transplantation of marrowderived mesenchymal stem cells in experimental myocardial infarction
    • Rahbarghazi R, Nassiri SM, Ahmadi SH, Mohammadi E, Rabbani S, Araghi A, Hosseinkhani H. Dynamic induction of pro-angiogenic milieu after transplantation of marrowderived mesenchymal stem cells in experimental myocardial infarction. Int J Cardiol. 2014; 173:453-66
    • (2014) Int J Cardiol , vol.173 , pp. 453-466
    • Rahbarghazi, R.1    Nassiri, S.M.2    Ahmadi, S.H.3    Mohammadi, E.4    Rabbani, S.5    Araghi, A.6    Hosseinkhani, H.7
  • 14
    • 1642373909 scopus 로고    scopus 로고
    • Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    • Kinnaird T, Stabile E, Burnett MS, Lee CW, Barr S, Fuchs S, Epstein SE. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res. 2004; 94:678-85
    • (2004) Circ Res , vol.94 , pp. 678-685
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3    Lee, C.W.4    Barr, S.5    Fuchs, S.6    Epstein, S.E.7
  • 17
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: composition, biogenesis and function
    • Thery C, Zitvogel L, Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol. 2002; 2: 569-79
    • (2002) Nat Rev Immunol , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 18
    • 33751199883 scopus 로고    scopus 로고
    • Exosomes: from biogenesis and secretion to biological function
    • Keller S, Sanderson MP, Stoeck A, Altevogt P. Exosomes: from biogenesis and secretion to biological function. Immunol Lett. 2006; 107:102-8
    • (2006) Immunol Lett , vol.107 , pp. 102-108
    • Keller, S.1    Sanderson, M.P.2    Stoeck, A.3    Altevogt, P.4
  • 19
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: extracellular organelles important in intercellular communication
    • Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010; 73:1907-20
    • (2010) J Proteomics , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 20
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9:654-9
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 21
    • 84888986034 scopus 로고    scopus 로고
    • Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells
    • Tadokoro H, Umezu T, Ohyashiki K, Hirano T, Ohyashiki JH. Exosomes derived from hypoxic leukemia cells enhance tube formation in endothelial cells. J Biol Chem. 2013; 288:34343-51
    • (2013) J Biol Chem , vol.288 , pp. 34343-34351
    • Tadokoro, H.1    Umezu, T.2    Ohyashiki, K.3    Hirano, T.4    Ohyashiki, J.H.5
  • 22
    • 84947201437 scopus 로고    scopus 로고
    • Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection
    • Yu B, Kim HW, Gong M, Wang J, Millard RW, Wang Y, Ashraf M, Xu M. Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection. Int J Cardiol. 2015; 182:349-60
    • (2015) Int J Cardiol , vol.182 , pp. 349-360
    • Yu, B.1    Kim, H.W.2    Gong, M.3    Wang, J.4    Millard, R.W.5    Wang, Y.6    Ashraf, M.7    Xu, M.8
  • 24
    • 84930924311 scopus 로고    scopus 로고
    • Extracellular vesicle microRNA transfer in cardiovascular disease
    • Das S, Halushka MK. Extracellular vesicle microRNA transfer in cardiovascular disease. Cardiovasc Pathol. 2015; 24:199-206
    • (2015) Cardiovasc Pathol , vol.24 , pp. 199-206
    • Das, S.1    Halushka, M.K.2
  • 25
    • 84880906480 scopus 로고    scopus 로고
    • MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease
    • Hulsmans M, Holvoet P. MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease. Cardiovasc Res. 2013; 100:7-18
    • (2013) Cardiovasc Res , vol.100 , pp. 7-18
    • Hulsmans, M.1    Holvoet, P.2
  • 26
    • 84856077973 scopus 로고    scopus 로고
    • Functional transfer of microRNA by exosomes
    • Stoorvogel W. Functional transfer of microRNA by exosomes. Blood. 2012; 119:646-8
    • (2012) Blood , vol.119 , pp. 646-648
    • Stoorvogel, W.1
  • 27
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010; 11:597-610
    • (2010) Nat Rev Genet , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 28
    • 28044471565 scopus 로고    scopus 로고
    • MicroRNA functions in animal development and human disease
    • Alvarez-Garcia I, Miska EA. MicroRNA functions in animal development and human disease. Development. 2005; 132:4653-62
    • (2005) Development , vol.132 , pp. 4653-4662
    • Alvarez-Garcia, I.1    Miska, E.A.2
  • 29
    • 68649114571 scopus 로고    scopus 로고
    • AngiomiRs-key regulators of angiogenesis
    • Wang S, Olson EN. AngiomiRs-key regulators of angiogenesis. Curr Opin Genet Dev. 2009; 19:205-11
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 205-211
    • Wang, S.1    Olson, E.N.2
  • 32
  • 33
    • 84861999021 scopus 로고    scopus 로고
    • Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies
    • Ratajczak MZ, Kucia M, Jadczyk T, Greco NJ, Wojakowski W, Tendera M, Ratajczak J. Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies. Leukemia. 2012; 26:1166-73
    • (2012) Leukemia , vol.26 , pp. 1166-1173
    • Ratajczak, M.Z.1    Kucia, M.2    Jadczyk, T.3    Greco, N.J.4    Wojakowski, W.5    Tendera, M.6    Ratajczak, J.7
  • 35
    • 84913582222 scopus 로고    scopus 로고
    • Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model
    • Bussche L, Van de Walle GR. Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model. Stem Cells Transl Med. 2014; 3:1514-25
    • (2014) Stem Cells Transl Med , vol.3 , pp. 1514-1525
    • Bussche, L.1    Van de Walle, G.R.2
  • 38
    • 34447632218 scopus 로고    scopus 로고
    • Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis
    • Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res. 2007; 101:59-68
    • (2007) Circ Res , vol.101 , pp. 59-68
    • Kuehbacher, A.1    Urbich, C.2    Zeiher, A.M.3    Dimmeler, S.4
  • 39
    • 84984889454 scopus 로고    scopus 로고
    • Mechanisms of mesenchymal stem/stromal cell function
    • Spees JL, Lee RH, Gregory CA. Mechanisms of mesenchymal stem/stromal cell function. Stem Cell Res Ther. 2016; 7:125
    • (2016) Stem Cell Res Ther , vol.7 , pp. 125
    • Spees, J.L.1    Lee, R.H.2    Gregory, C.A.3
  • 40
    • 84856695673 scopus 로고    scopus 로고
    • Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease
    • Creemers EE, Tijsen AJ, Pinto YM. Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease. Circ Res. 2012; 110:483-95
    • (2012) Circ Res , vol.110 , pp. 483-495
    • Creemers, E.E.1    Tijsen, A.J.2    Pinto, Y.M.3
  • 41
    • 84872063933 scopus 로고    scopus 로고
    • AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: role for proangiogenic effects and alterations in type 2 diabetics
    • Mocharla P, Briand S, Giannotti G, Dorries C, Jakob P, Paneni F, Luscher T, Landmesser U. AngiomiR-126 expression and secretion from circulating CD34(+) and CD14(+) PBMCs: role for proangiogenic effects and alterations in type 2 diabetics. Blood. 2013; 121:226-36
    • (2013) Blood , vol.121 , pp. 226-236
    • Mocharla, P.1    Briand, S.2    Giannotti, G.3    Dorries, C.4    Jakob, P.5    Paneni, F.6    Luscher, T.7    Landmesser, U.8
  • 42
    • 84989184707 scopus 로고    scopus 로고
    • Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice
    • Wang X, Gu H, Huang W, Peng J, Li Y, Yang L, Qin D, Essandoh K, Wang Y, Peng T, Fan GC, AUID-Oho. Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice. Diabetes. 2016; 65:3111-28
    • (2016) Diabetes , vol.65 , pp. 3111-3128
    • Wang, X.1    Gu, H.2    Huang, W.3    Peng, J.4    Li, Y.5    Yang, L.6    Qin, D.7    Essandoh, K.8    Wang, Y.9    Peng, T.10    Fan, G.C.11
  • 43
    • 84944387386 scopus 로고    scopus 로고
    • Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice
    • Geiger A, Walker A, Nissen E. Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice. Biochem Biophys Res Commun. 2015; 467:303-9
    • (2015) Biochem Biophys Res Commun , vol.467 , pp. 303-309
    • Geiger, A.1    Walker, A.2    Nissen, E.3
  • 44
    • 84907521913 scopus 로고    scopus 로고
    • MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells
    • Eirin A, Riester SM, Zhu XY, Tang H, Evans JM, O'Brien D, van Wijnen AJ, Lerman LO. MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells. Gene. 2014; 551:55-64
    • (2014) Gene , vol.551 , pp. 55-64
    • Eirin, A.1    Riester, S.M.2    Zhu, X.Y.3    Tang, H.4    Evans, J.M.5    O'Brien, D.6    van Wijnen, A.J.7    Lerman, L.O.8
  • 46
    • 59649085554 scopus 로고    scopus 로고
    • Angiogenesis: a team effort coordinated by notch
    • Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell. 2009; 16:196-208
    • (2009) Dev Cell , vol.16 , pp. 196-208
    • Phng, L.K.1    Gerhardt, H.2
  • 50
    • 84904768520 scopus 로고    scopus 로고
    • Cardiomyocytes mediate antiangiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells
    • Wang X, Huang W, Liu G, Cai W, Millard RW, Wang Y, Chang J, Peng T, Fan GC. Cardiomyocytes mediate antiangiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. J Mol Cell Cardiol. 2014; 74:139-50
    • (2014) J Mol Cell Cardiol , vol.74 , pp. 139-150
    • Wang, X.1    Huang, W.2    Liu, G.3    Cai, W.4    Millard, R.W.5    Wang, Y.6    Chang, J.7    Peng, T.8    Fan, G.C.9
  • 52
    • 85007406405 scopus 로고    scopus 로고
    • MSC exosome as a cellfree MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment
    • Toh WS, Lai RC, Hui JH, Lim SK. MSC exosome as a cellfree MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. Semin Cell Dev Biol. 2016; 67: 56-64
    • (2016) Semin Cell Dev Biol , vol.67 , pp. 56-64
    • Toh, W.S.1    Lai, R.C.2    Hui, J.H.3    Lim, S.K.4
  • 53
    • 84955357177 scopus 로고    scopus 로고
    • The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration
    • Konala VB, Mamidi MK, Bhonde R, Das AK, Pochampally R, Pal R. The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration. Cytotherapy. 2016; 18:13-24
    • (2016) Cytotherapy , vol.18 , pp. 13-24
    • Konala, V.B.1    Mamidi, M.K.2    Bhonde, R.3    Das, A.K.4    Pochampally, R.5    Pal, R.6
  • 54
    • 84883426378 scopus 로고    scopus 로고
    • Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles
    • Yu B, Gong M, Wang Y, Millard RW, Pasha Z, Yang Y, Ashraf M, Xu M. Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles. PLOS ONE. 2013; 8:e73304
    • (2013) PLOS ONE , vol.8
    • Yu, B.1    Gong, M.2    Wang, Y.3    Millard, R.W.4    Pasha, Z.5    Yang, Y.6    Ashraf, M.7    Xu, M.8
  • 55
    • 33846902276 scopus 로고    scopus 로고
    • The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation
    • Diehl F, Rossig L, Zeiher AM, Dimmeler S, Urbich C. The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation. Blood. 2007; 109:1472-8
    • (2007) Blood , vol.109 , pp. 1472-1478
    • Diehl, F.1    Rossig, L.2    Zeiher, A.M.3    Dimmeler, S.4    Urbich, C.5
  • 56
    • 84886079060 scopus 로고    scopus 로고
    • Enhanced mesenchymal stem cell survival induced by GATA-4 overexpression is partially mediated by regulation of the miR-15 family
    • Yu B, Gong M, He Z, Wang YG, Millard RW, Ashraf M, Xu M. Enhanced mesenchymal stem cell survival induced by GATA-4 overexpression is partially mediated by regulation of the miR-15 family. Int J Biochem Cell Biol. 2013; 45:2724-35
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 2724-2735
    • Yu, B.1    Gong, M.2    He, Z.3    Wang, Y.G.4    Millard, R.W.5    Ashraf, M.6    Xu, M.7


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