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Volumn 19, Issue 6, 2018, Pages

Microbiome-gut-brain axis and toll-like receptors in parkinson’s disease

Author keywords

Brain gut axis; Central nervous system; Enteric microbiota; Enteric nervous system; Gastrointestinal dysfunctions; Glial cells; Gut dysbiosis; Innate immunity; Intestinal barrier permeability; Microglia; Neurons; Parkinson s disease; Pharmacological treatment; Probiotics; Toll like receptors; synuclein

Indexed keywords

PROBIOTIC AGENT; SHORT CHAIN FATTY ACID; TOLL LIKE RECEPTOR 1; ANTIINFECTIVE AGENT; TOLL LIKE RECEPTOR;

EID: 85048300857     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms19061689     Document Type: Review
Times cited : (252)

References (137)
  • 1
    • 85011299976 scopus 로고    scopus 로고
    • Epidemiology of Parkinson’s disease
    • Tysnes, O.B.; Storstein, A. Epidemiology of Parkinson’s disease. J. Neural. Transm. 2017, 124, 901–905. [PubMed]
    • (2017) J. Neural. Transm. , vol.124 , pp. 901-905
    • Tysnes, O.B.1    Storstein, A.2
  • 2
    • 85039938075 scopus 로고    scopus 로고
    • Gut microbiota dysfunction as reliable non-invasive early diagnostic biomarkers in the pathophysiology of Parkinson’s disease: A critical review
    • Nair, A.T.; Ramachandran, V.; Joghee, N.M.; Antony, S.; Ramalingam, G. Gut microbiota dysfunction as reliable non-invasive early diagnostic biomarkers in the pathophysiology of Parkinson’s disease: A critical review. J. Neurogastroenterol. Motil. 2018, 24, 30–42. [CrossRef] [PubMed]
    • (2018) J. Neurogastroenterol. Motil. , vol.24 , pp. 30-42
    • Nair, A.T.1    Ramachandran, V.2    Joghee, N.M.3    Antony, S.4    Ramalingam, G.5
  • 5
    • 33947200337 scopus 로고    scopus 로고
    • Parkinson’s disease: Lesions in dorsal horn layer i, involvement of parasympathetic and sympathetic pre-and postganglionic neurons
    • Braak, H.; Sastre, M.; Bohl, J.R.; de Vos, R.A.; Del Tredici, K. Parkinson’s disease: Lesions in dorsal horn layer i, involvement of parasympathetic and sympathetic pre-and postganglionic neurons. Acta Neuropathol. 2007, 113, 421–429. [CrossRef] [PubMed]
    • (2007) Acta Neuropathol , vol.113 , pp. 421-429
    • Braak, H.1    Sastre, M.2    Bohl, J.R.3    de Vos, R.A.4    Del Tredici, K.5
  • 6
    • 84940956493 scopus 로고    scopus 로고
    • Parkinson’s disease
    • Kalia, L.V.; Lang, A.E. Parkinson’s disease. Lancet 2015, 386, 896–912. [CrossRef]
    • (2015) Lancet , vol.386 , pp. 896-912
    • Kalia, L.V.1    Lang, A.E.2
  • 8
    • 79952051533 scopus 로고    scopus 로고
    • Levodopa in the treatment of Parkinson’s disease: An old drug still going strong
    • Poewe, W.; Antonini, A.; Zijlmans, J.C.; Burkhard, P.R.; Vingerhoets, F. Levodopa in the treatment of Parkinson’s disease: An old drug still going strong. Clin. Interv. Aging 2010, 5, 229–238. [PubMed]
    • (2010) Clin. Interv. Aging , vol.5 , pp. 229-238
    • Poewe, W.1    Antonini, A.2    Zijlmans, J.C.3    Burkhard, P.R.4    Vingerhoets, F.5
  • 9
    • 84903447493 scopus 로고    scopus 로고
    • Psychological disorders in gastrointestinal disease: Epiphenomenon, cause or consequence?
    • PubMed
    • Shah, E.; Rezaie, A.; Riddle, M.; Pimentel, M. Psychological disorders in gastrointestinal disease: Epiphenomenon, cause or consequence? Ann. Gastroenterol. 2014, 27, 224–230. [PubMed]
    • (2014) Ann. Gastroenterol. , vol.27 , pp. 224-230
    • Shah, E.1    Rezaie, A.2    Riddle, M.3    Pimentel, M.4
  • 10
    • 84924804354 scopus 로고    scopus 로고
    • The relationship between irritable bowel syndrome and psychiatric disorders: From molecular changes to clinical manifestations
    • Fadgyas-Stanculete, M.; Buga, A.M.; Popa-Wagner, A.; Dumitrascu, D.L. The relationship between irritable bowel syndrome and psychiatric disorders: From molecular changes to clinical manifestations. J. Mol. Psychiatry 2014, 2, 4. [CrossRef] [PubMed]
    • (2014) J. Mol. Psychiatry , vol.2 , pp. 4
    • Fadgyas-Stanculete, M.1    Buga, A.M.2    Popa-Wagner, A.3    Dumitrascu, D.L.4
  • 14
    • 85012041154 scopus 로고    scopus 로고
    • The interplay between inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: Clinical implications
    • Dumnicka, P.; Maduzia, D.; Ceranowicz, P.; Olszanecki, R.; Drozdz, R.; Kusnierz-Cabala, B. The interplay between inflammation, coagulation and endothelial injury in the early phase of acute pancreatitis: Clinical implications. Int. J. Mol. Sci. 2017, 18, 354. [CrossRef] [PubMed]
    • (2017) Int. J. Mol. Sci. , vol.18 , pp. 354
    • Dumnicka, P.1    Maduzia, D.2    Ceranowicz, P.3    Olszanecki, R.4    Drozdz, R.5    Kusnierz-Cabala, B.6
  • 15
    • 84926670347 scopus 로고    scopus 로고
    • Stress-induced visceral pain: Toward animal models of irritable-bowel syndrome and associated comorbidities
    • Moloney, R.D.; O’Mahony, S.M.; Dinan, T.G.; Cryan, J.F. Stress-induced visceral pain: Toward animal models of irritable-bowel syndrome and associated comorbidities. Front. Psychiatry 2015, 6, 15. [CrossRef] [PubMed]
    • (2015) Front. Psychiatry , vol.6 , pp. 15
    • Moloney, R.D.1    O’Mahony, S.M.2    Dinan, T.G.3    Cryan, J.F.4
  • 17
    • 33750347509 scopus 로고    scopus 로고
    • The role of the sympathetic nervous system in intestinal inflammation
    • Straub, R.H.; Wiest, R.; Strauch, U.G.; Harle, P.; Scholmerich, J. The role of the sympathetic nervous system in intestinal inflammation. Gut 2006, 55, 1640–1649. [CrossRef] [PubMed]
    • (2006) Gut , vol.55 , pp. 1640-1649
    • Straub, R.H.1    Wiest, R.2    Strauch, U.G.3    Harle, P.4    Scholmerich, J.5
  • 18
    • 84979895775 scopus 로고    scopus 로고
    • Lost your nerve? Modulating the parasympathetic nervous system to treat inflammatory bowel disease
    • Costantini, T.W.; Baird, A. Lost your nerve? Modulating the parasympathetic nervous system to treat inflammatory bowel disease. J. Physiol. 2016, 594, 4097–4098. [CrossRef] [PubMed]
    • (2016) J. Physiol. , vol.594 , pp. 4097-4098
    • Costantini, T.W.1    Baird, A.2
  • 20
    • 0035715721 scopus 로고    scopus 로고
    • Effect of sensory nerves and cgrp on the development of caerulein-induced pancreatitis and pancreatic recovery
    • Warzecha, Z.; Dembinski, A.; Ceranowicz, P.; Stachura, J.; Tomaszewska, R.; Konturek, S.J. Effect of sensory nerves and cgrp on the development of caerulein-induced pancreatitis and pancreatic recovery. J. Physiol. Pharmacol. 2001, 52, 679–704. [PubMed]
    • (2001) J. Physiol. Pharmacol. , vol.52 , pp. 679-704
    • Warzecha, Z.1    Dembinski, A.2    Ceranowicz, P.3    Stachura, J.4    Tomaszewska, R.5    Konturek, S.J.6
  • 22
    • 0029085480 scopus 로고
    • The role of capsaicin-sensitive sensory neurons and nitric oxide in regulation of gastric mucosal growth
    • Dembinski, A.; Warzecha, Z.; Ceranowicz, P.; Konturek, S.J. The role of capsaicin-sensitive sensory neurons and nitric oxide in regulation of gastric mucosal growth. J. Physiol. Pharmacol. 1995, 46, 351–362. [PubMed]
    • (1995) J. Physiol. Pharmacol. , vol.46 , pp. 351-362
    • Dembinski, A.1    Warzecha, Z.2    Ceranowicz, P.3    Konturek, S.J.4
  • 23
    • 0029953255 scopus 로고    scopus 로고
    • Influence of capsaicin-sensitive afferent neurons and nitric oxide (No) on cerulein-induced pancreatitis in rats
    • Dembinski, A.; Warzecha, Z.; Konturek, P.J.; Ceranowicz, P.; Konturek, S.J. Influence of capsaicin-sensitive afferent neurons and nitric oxide (no) on cerulein-induced pancreatitis in rats. Int. J. Pancreatol. 1996, 19, 179–189. [PubMed]
    • (1996) Int. J. Pancreatol. , vol.19 , pp. 179-189
    • Dembinski, A.1    Warzecha, Z.2    Konturek, P.J.3    Ceranowicz, P.4    Konturek, S.J.5
  • 29
    • 85047155786 scopus 로고    scopus 로고
    • Influence of commensal microbiota on the enteric nervous system and its role in neurodegenerative diseases
    • Endres, K.; Schafer, K.H. Influence of commensal microbiota on the enteric nervous system and its role in neurodegenerative diseases. J. Innate Immun. 2018, 1–9. [CrossRef] [PubMed]
    • (2018) J. Innate Immun. , pp. 1-9
    • Endres, K.1    Schafer, K.H.2
  • 30
    • 84864598303 scopus 로고    scopus 로고
    • Toll-like receptors promote mutually beneficial commensal-host interactions
    • Kubinak, J.L.; Round, J.L. Toll-like receptors promote mutually beneficial commensal-host interactions. PLoS Pathog. 2012, 8, e1002785. [CrossRef] [PubMed]
    • (2012) Plos Pathog , vol.8
    • Kubinak, J.L.1    Round, J.L.2
  • 31
    • 85019061613 scopus 로고    scopus 로고
    • Gut microbiota—At the intersection of everything?
    • Cani, P.D. Gut microbiota—At the intersection of everything? Nat. Rev. Gastroenterol. Hepatol. 2017, 14, 321–322. [CrossRef] [PubMed]
    • (2017) Nat. Rev. Gastroenterol. Hepatol. , vol.14 , pp. 321-322
    • Cani, P.D.1
  • 32
    • 84926315282 scopus 로고    scopus 로고
    • The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems
    • PubMed
    • Carabotti, M.; Scirocco, A.; Maselli, M.A.; Severi, C. The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Ann. Gastroenterol. 2015, 28, 203–209. [PubMed]
    • (2015) Ann. Gastroenterol. , vol.28 , pp. 203-209
    • Carabotti, M.1    Scirocco, A.2    Maselli, M.A.3    Severi, C.4
  • 33
    • 84961288867 scopus 로고    scopus 로고
    • Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans
    • Sender, R.; Fuchs, S.; Milo, R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell 2016, 164, 337–340. [CrossRef] [PubMed]
    • (2016) Cell , vol.164 , pp. 337-340
    • Sender, R.1    Fuchs, S.2    Milo, R.3
  • 37
    • 84865286121 scopus 로고    scopus 로고
    • Antibiotics, microbiota, and immune defense
    • Ubeda, C.; Pamer, E.G. Antibiotics, microbiota, and immune defense. Trends Immunol. 2012, 33, 459–466. [CrossRef] [PubMed]
    • (2012) Trends Immunol , vol.33 , pp. 459-466
    • Ubeda, C.1    Pamer, E.G.2
  • 41
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour
    • Cryan, J.F.; Dinan, T.G. Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nat. Rev. Neurosci. 2012, 13, 701–712. [CrossRef] [PubMed]
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 42
    • 84877145046 scopus 로고    scopus 로고
    • Gut-brain axis: How the microbiome influences anxiety and depression
    • Foster, J.A.; McVey Neufeld, K.A. Gut-brain axis: How the microbiome influences anxiety and depression. Trends Neurosci. 2013, 36, 305–312. [CrossRef] [PubMed]
    • (2013) Trends Neurosci , vol.36 , pp. 305-312
    • Foster, J.A.1    McVey Neufeld, K.A.2
  • 43
    • 85006741566 scopus 로고    scopus 로고
    • The neuro-endocrinological role of microbial glutamate and gaba signaling
    • Mazzoli, R.; Pessione, E. The neuro-endocrinological role of microbial glutamate and gaba signaling. Front. Microbiol. 2016, 7, 1934. [CrossRef] [PubMed]
    • (2016) Front. Microbiol. , vol.7 , pp. 1934
    • Mazzoli, R.1    Pessione, E.2
  • 44
    • 79960464084 scopus 로고    scopus 로고
    • Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics
    • Lyte, M. Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. Bioessays 2011, 33, 574–581. [CrossRef] [PubMed]
    • (2011) Bioessays , vol.33 , pp. 574-581
    • Lyte, M.1
  • 45
    • 84944740240 scopus 로고    scopus 로고
    • Cronobacter sakazakii infection alters serotonin transporter and improved fear memory retention in the rat
    • Sivamaruthi, B.S.; Madhumita, R.; Balamurugan, K.; Rajan, K.E. Cronobacter sakazakii infection alters serotonin transporter and improved fear memory retention in the rat. Front. Pharmacol. 2015, 6, 188. [CrossRef] [PubMed]
    • (2015) Front. Pharmacol. , vol.6 , pp. 188
    • Sivamaruthi, B.S.1    Madhumita, R.2    Balamurugan, K.3    Rajan, K.E.4
  • 46
    • 84923196668 scopus 로고    scopus 로고
    • Peptidyl hormones of endocrine cells origin in the gut—Their discovery and physiological relevance
    • PubMed
    • Ceranowicz, P.; Warzecha, Z.; Dembinski, A. Peptidyl hormones of endocrine cells origin in the gut—Their discovery and physiological relevance. J. Physiol. Pharmacol. 2015, 66, 11–27. [PubMed]
    • (2015) J. Physiol. Pharmacol. , vol.66 , pp. 11-27
    • Ceranowicz, P.1    Warzecha, Z.2    Dembinski, A.3
  • 48
    • 84912141027 scopus 로고    scopus 로고
    • Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
    • O’Mahony, S.M.; Clarke, G.; Borre, Y.E.; Dinan, T.G.; Cryan, J.F. Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav. Brain Res. 2015, 277, 32–48. [CrossRef] [PubMed]
    • (2015) Behav. Brain Res. , vol.277 , pp. 32-48
    • O’Mahony, S.M.1    Clarke, G.2    Borre, Y.E.3    Dinan, T.G.4    Cryan, J.F.5
  • 49
    • 85023201069 scopus 로고    scopus 로고
    • Microbiome, inflammation, epigenetic alterations, and mental diseases
    • Alam, R.; Abdolmaleky, H.M.; Zhou, J.R. Microbiome, inflammation, epigenetic alterations, and mental diseases. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2017, 174, 651–660. [CrossRef] [PubMed]
    • (2017) Am. J. Med. Genet. B Neuropsychiatr. Genet , vol.174 , pp. 651-660
    • Alam, R.1    Abdolmaleky, H.M.2    Zhou, J.R.3
  • 50
    • 84915796530 scopus 로고    scopus 로고
    • The gut microbiome and the brain
    • Galland, L. The gut microbiome and the brain. J. Med. Food 2014, 17, 1261–1272. [CrossRef] [PubMed]
    • (2014) J. Med. Food , vol.17 , pp. 1261-1272
    • Galland, L.1
  • 51
    • 85009739519 scopus 로고    scopus 로고
    • Bacterial signaling to the nervous system through toxins and metabolites
    • Yang, N.J.; Chiu, I.M. Bacterial signaling to the nervous system through toxins and metabolites. J. Mol. Biol. 2017, 429, 587–605. [CrossRef] [PubMed]
    • (2017) J. Mol. Biol , vol.429 , pp. 587-605
    • Yang, N.J.1    Chiu, I.M.2
  • 52
    • 84867845255 scopus 로고    scopus 로고
    • The interplay between the intestinal microbiota and the brain
    • Collins, S.M.; Surette, M.; Bercik, P. The interplay between the intestinal microbiota and the brain. Nat. Rev. Microbiol. 2012, 10, 735–742. [CrossRef] [PubMed]
    • (2012) Nat. Rev. Microbiol. , vol.10 , pp. 735-742
    • Collins, S.M.1    Surette, M.2    Bercik, P.3
  • 53
    • 84942789153 scopus 로고    scopus 로고
    • Brain-gut-microbiota axis in Parkinson’s disease
    • Mulak, A.; Bonaz, B. Brain-gut-microbiota axis in Parkinson’s disease. World J. Gastroenterol. 2015, 21, 10609–10620. [CrossRef] [PubMed]
    • (2015) World J. Gastroenterol. , vol.21 , pp. 10609-10620
    • Mulak, A.1    Bonaz, B.2
  • 57
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in meissner’s and auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology
    • Braak, H.; de Vos, R.A.; Bohl, J.; Del Tredici, K. Gastric alpha-synuclein immunoreactive inclusions in meissner’s and auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology. Neurosci. Lett. 2006, 396, 67–72. [CrossRef] [PubMed]
    • (2006) Neurosci. Lett. , vol.396 , pp. 67-72
    • Braak, H.1    de Vos, R.A.2    Bohl, J.3    Del Tredici, K.4
  • 60
    • 82455206282 scopus 로고    scopus 로고
    • Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s disease
    • Forsyth, C.B.; Shannon, K.M.; Kordower, J.H.; Voigt, R.M.; Shaikh, M.; Jaglin, J.A.; Estes, J.D.; Dodiya, H.B.; Keshavarzian, A. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson’s disease. PLoS ONE 2011, 6, e28032. [CrossRef] [PubMed]
    • (2011) Plos ONE , vol.6
    • Forsyth, C.B.1    Shannon, K.M.2    Kordower, J.H.3    Voigt, R.M.4    Shaikh, M.5    Jaglin, J.A.6    Estes, J.D.7    Dodiya, H.B.8    Keshavarzian, A.9
  • 62
    • 70449529633 scopus 로고    scopus 로고
    • The blood-brain barrier and immune function and dysfunction
    • Banks, W.A.; Erickson, M.A. The blood-brain barrier and immune function and dysfunction. Neurobiol. Dis. 2010, 37, 26–32. [CrossRef] [PubMed]
    • (2010) Neurobiol. Dis. , vol.37 , pp. 26-32
    • Banks, W.A.1    Erickson, M.A.2
  • 66
    • 79959846783 scopus 로고    scopus 로고
    • Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic rem sleep behaviour disorder: A peripheral biomarker for early Parkinson’s disease?
    • Unger, M.M.; Moller, J.C.; Mankel, K.; Eggert, K.M.; Bohne, K.; Bodden, M.; Stiasny-Kolster, K.; Kann, P.H.; Mayer, G.; Tebbe, J.J.; et al. Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic rem sleep behaviour disorder: A peripheral biomarker for early Parkinson’s disease? J. Neurol. 2011, 258, 982–990. [CrossRef] [PubMed]
    • (2011) J. Neurol. , vol.258 , pp. 982-990
    • Unger, M.M.1    Moller, J.C.2    Mankel, K.3    Eggert, K.M.4    Bohne, K.5    Bodden, M.6    Stiasny-Kolster, K.7    Kann, P.H.8    Mayer, G.9    Tebbe, J.J.10
  • 68
    • 66449088641 scopus 로고    scopus 로고
    • Pathogen recognition and inflammatory signaling in innate immune defenses
    • Mogensen, T.H. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin. Microbiol. Rev. 2009, 22, 240–273. [CrossRef] [PubMed]
    • (2009) Clin. Microbiol. Rev. , vol.22 , pp. 240-273
    • Mogensen, T.H.1
  • 69
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S.; Uematsu, S.; Takeuchi, O. Pathogen recognition and innate immunity. Cell 2006, 124, 783–801. [CrossRef] [PubMed]
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 70
    • 0034601309 scopus 로고    scopus 로고
    • Innate immunity
    • Medzhitov, R.; Janeway, C., Jr. Innate immunity. N. Engl. J. Med. 2000, 343, 338–344. [CrossRef] [PubMed]
    • (2000) N. Engl. J. Med. , vol.343 , pp. 338-344
    • Medzhitov, R.1    Janeway, C.2
  • 71
    • 0024299087 scopus 로고
    • The toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
    • Hashimoto, C.; Hudson, K.L.; Anderson, K.V. The toll gene of drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 1988, 52, 269–279. [CrossRef]
    • (1988) Cell , vol.52 , pp. 269-279
    • Hashimoto, C.1    Hudson, K.L.2    Anderson, K.V.3
  • 74
    • 79955745301 scopus 로고    scopus 로고
    • Toll-like receptor signaling in neural plasticity and disease
    • Okun, E.; Griffioen, K.J.; Mattson, M.P. Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci. 2011, 34, 269–281. [CrossRef] [PubMed]
    • (2011) Trends Neurosci , vol.34 , pp. 269-281
    • Okun, E.1    Griffioen, K.J.2    Mattson, M.P.3
  • 75
    • 26444552110 scopus 로고    scopus 로고
    • Virus infection switches tlr-3-positive human neurons to become strong producers of beta interferon
    • Prehaud, C.; Megret, F.; Lafage, M.; Lafon, M. Virus infection switches tlr-3-positive human neurons to become strong producers of beta interferon. J. Virol. 2005, 79, 12893–12904. [CrossRef] [PubMed]
    • (2005) J. Virol. , vol.79 , pp. 12893-12904
    • Prehaud, C.1    Megret, F.2    Lafage, M.3    Lafon, M.4
  • 76
    • 70449730854 scopus 로고    scopus 로고
    • Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia
    • Barajon, I.; Serrao, G.; Arnaboldi, F.; Opizzi, E.; Ripamonti, G.; Balsari, A.; Rumio, C. Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia. J. Histochem. Cytochem. 2009, 57, 1013–1023. [CrossRef] [PubMed]
    • (2009) J. Histochem. Cytochem. , vol.57 , pp. 1013-1023
    • Barajon, I.1    Serrao, G.2    Arnaboldi, F.3    Opizzi, E.4    Ripamonti, G.5    Balsari, A.6    Rumio, C.7
  • 77
    • 84918564833 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways
    • Kawasaki, T.; Kawai, T. Toll-like receptor signaling pathways. Front. Immunol. 2014, 5, 461. [CrossRef] [PubMed]
    • (2014) Front. Immunol. , vol.5 , pp. 461
    • Kawasaki, T.1    Kawai, T.2
  • 78
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi, O.; Akira, S. Pattern recognition receptors and inflammation. Cell 2010, 140, 805–820. [CrossRef] [PubMed]
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 79
    • 84875898265 scopus 로고    scopus 로고
    • Neuron-released oligomeric alpha-synuclein is an endogenous agonist of tlr2 for paracrine activation of microglia
    • Kim, C.; Ho, D.H.; Suk, J.E.; You, S.; Michael, S.; Kang, J.; Joong Lee, S.; Masliah, E.; Hwang, D.; Lee, H.J.; et al. Neuron-released oligomeric alpha-synuclein is an endogenous agonist of tlr2 for paracrine activation of microglia. Nat. Commun. 2013, 4, 1562. [CrossRef] [PubMed]
    • (2013) Nat. Commun. , vol.4 , pp. 1562
    • Kim, C.1    Ho, D.H.2    Suk, J.E.3    You, S.4    Michael, S.5    Kang, J.6    Joong Lee, S.7    Masliah, E.8    Hwang, D.9    Lee, H.J.10
  • 80
    • 84929619164 scopus 로고    scopus 로고
    • Activation of myd88-dependent tlr1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders
    • Daniele, S.G.; Beraud, D.; Davenport, C.; Cheng, K.; Yin, H.; Maguire-Zeiss, K.A. Activation of myd88-dependent tlr1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders. Sci. Signal. 2015, 8, ra45. [CrossRef] [PubMed]
    • (2015) Sci. Signal. , vol.8
    • Daniele, S.G.1    Beraud, D.2    Davenport, C.3    Cheng, K.4    Yin, H.5    Maguire-Zeiss, K.A.6
  • 81
    • 84858652204 scopus 로고    scopus 로고
    • Misfolded alpha-synuclein and toll-like receptors: Therapeutic targets for Parkinson’s disease
    • Beraud, D.; Maguire-Zeiss, K.A. Misfolded alpha-synuclein and toll-like receptors: Therapeutic targets for Parkinson’s disease. Parkinsonism. Relat. Disord. 2012, 18 (Suppl. S1), S17–S20. [CrossRef]
    • (2012) Parkinsonism. Relat. Disord. , vol.18 , pp. S17-S20
    • Beraud, D.1    Maguire-Zeiss, K.A.2
  • 82
    • 84872595532 scopus 로고    scopus 로고
    • Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia
    • Fellner, L.; Irschick, R.; Schanda, K.; Reindl, M.; Klimaschewski, L.; Poewe, W.; Wenning, G.K.; Stefanova, N. Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia. Glia 2013, 61, 349–360. [CrossRef] [PubMed]
    • (2013) Glia , vol.61 , pp. 349-360
    • Fellner, L.1    Irschick, R.2    Schanda, K.3    Reindl, M.4    Klimaschewski, L.5    Poewe, W.6    Wenning, G.K.7    Stefanova, N.8
  • 84
    • 84920990887 scopus 로고    scopus 로고
    • Dopamine controls systemic inflammation through inhibition of nlrp3 inflammasome
    • Yan, Y.; Jiang, W.; Liu, L.; Wang, X.; Ding, C.; Tian, Z.; Zhou, R. Dopamine controls systemic inflammation through inhibition of nlrp3 inflammasome. Cell 2015, 160, 62–73. [CrossRef] [PubMed]
    • (2015) Cell , vol.160 , pp. 62-73
    • Yan, Y.1    Jiang, W.2    Liu, L.3    Wang, X.4    Ding, C.5    Tian, Z.6    Zhou, R.7
  • 85
    • 84873123076 scopus 로고    scopus 로고
    • Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies
    • Codolo, G.; Plotegher, N.; Pozzobon, T.; Brucale, M.; Tessari, I.; Bubacco, L.; de Bernard, M. Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies. PLoS ONE 2013, 8, e55375. [CrossRef] [PubMed]
    • (2013) Plos ONE , vol.8
    • Codolo, G.1    Plotegher, N.2    Pozzobon, T.3    Brucale, M.4    Tessari, I.5    Bubacco, L.6    de Bernard, M.7
  • 86
    • 85041724931 scopus 로고    scopus 로고
    • Innate immunity and neurodegeneration
    • Labzin, L.I.; Heneka, M.T.; Latz, E. Innate immunity and neurodegeneration. Annu. Rev. Med. 2018, 69, 437–449. [CrossRef] [PubMed]
    • (2018) Annu. Rev. Med. , vol.69 , pp. 437-449
    • Labzin, L.I.1    Heneka, M.T.2    Latz, E.3
  • 87
    • 85019979276 scopus 로고    scopus 로고
    • Neuronal toll-like receptors and neuro-immunity in Parkinson’s disease, Alzheimer’s disease and stroke
    • Rietdijk, C.D.; van Wezel, R.J.; Garssen, J.; Kraneveld, A.D. Neuronal toll-like receptors and neuro-immunity in Parkinson’s disease, Alzheimer’s disease and stroke. Neuroimmunol. Neuroinflamm. 2016, 3, 27–37. [CrossRef]
    • (2016) Neuroimmunol. Neuroinflamm. , vol.3 , pp. 27-37
    • Rietdijk, C.D.1    van Wezel, R.J.2    Garssen, J.3    Kraneveld, A.D.4
  • 88
    • 84866734401 scopus 로고    scopus 로고
    • Inflammation and neurodegeneration: The story ‘retolled’
    • Drouin-Ouellet, J.; Cicchetti, F. Inflammation and neurodegeneration: The story ‘retolled’. Trends Pharmacol. Sci. 2012, 33, 542–551. [CrossRef] [PubMed]
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 542-551
    • Drouin-Ouellet, J.1    Cicchetti, F.2
  • 89
    • 84897954445 scopus 로고    scopus 로고
    • Microglial dysfunction in brain aging and Alzheimer’s disease
    • Mosher, K.I.; Wyss-Coray, T. Microglial dysfunction in brain aging and Alzheimer’s disease. Biochem. Pharmacol. 2014, 88, 594–604. [CrossRef] [PubMed]
    • (2014) Biochem. Pharmacol. , vol.88 , pp. 594-604
    • Mosher, K.I.1    Wyss-Coray, T.2
  • 91
    • 85064006776 scopus 로고    scopus 로고
    • The gut-brain axis: Is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?
    • Houser, M.C.; Tansey, M.G. The gut-brain axis: Is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis? NPJ Parkinsons Dis. 2017, 3, 3. [CrossRef] [PubMed]
    • (2017) NPJ Parkinsons Dis , vol.3 , pp. 3
    • Houser, M.C.1    Tansey, M.G.2
  • 92
    • 80052473816 scopus 로고    scopus 로고
    • Toll-like receptor 4 promotes alpha-synuclein clearance and survival of nigral dopaminergic neurons
    • Stefanova, N.; Fellner, L.; Reindl, M.; Masliah, E.; Poewe, W.; Wenning, G.K. Toll-like receptor 4 promotes alpha-synuclein clearance and survival of nigral dopaminergic neurons. Am. J. Pathol. 2011, 179, 954–963. [CrossRef] [PubMed]
    • (2011) Am. J. Pathol. , vol.179 , pp. 954-963
    • Stefanova, N.1    Fellner, L.2    Reindl, M.3    Masliah, E.4    Poewe, W.5    Wenning, G.K.6
  • 93
    • 84925348854 scopus 로고    scopus 로고
    • Mechanisms of molecular mimicry involving the microbiota in neurodegeneration
    • Friedland, R.P. Mechanisms of molecular mimicry involving the microbiota in neurodegeneration. J. Alzheimers Dis. 2015, 45, 349–362. [CrossRef] [PubMed]
    • (2015) J. Alzheimers Dis. , vol.45 , pp. 349-362
    • Friedland, R.P.1
  • 95
    • 85007490624 scopus 로고    scopus 로고
    • Intestinal serotonin transporter inhibition by toll-like receptor 2 activation. A feedback modulation
    • Latorre, E.; Layunta, E.; Grasa, L.; Castro, M.; Pardo, J.; Gomollon, F.; Alcalde, A.I.; Mesonero, J.E. Intestinal serotonin transporter inhibition by toll-like receptor 2 activation. A feedback modulation. PLoS ONE 2016, 11, e0169303. [CrossRef] [PubMed]
    • (2016) Plos ONE , vol.11
    • Latorre, E.1    Layunta, E.2    Grasa, L.3    Castro, M.4    Pardo, J.5    Gomollon, F.6    Alcalde, A.I.7    Mesonero, J.E.8
  • 97
    • 84924901925 scopus 로고    scopus 로고
    • Activation of toll like receptor 4 attenuates gaba synthesis and postsynaptic gaba receptor activities in the spinal dorsal horn via releasing interleukin-1 beta
    • Yan, X.; Jiang, E.; Weng, H.R. Activation of toll like receptor 4 attenuates gaba synthesis and postsynaptic gaba receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. J. Neuroinflamm. 2015, 12, 222. [CrossRef] [PubMed]
    • (2015) J. Neuroinflamm. , vol.12 , pp. 222
    • Yan, X.1    Jiang, E.2    Weng, H.R.3
  • 99
    • 84982994263 scopus 로고    scopus 로고
    • Tlr ligands and butyrate increase pyy expression through two distinct but inter-regulated pathways
    • Larraufie, P.; Dore, J.; Lapaque, N.; Blottiere, H.M. Tlr ligands and butyrate increase pyy expression through two distinct but inter-regulated pathways. Cell. Microbiol. 2017, 19. [CrossRef] [PubMed]
    • (2017) Cell. Microbiol. , vol.19
    • Larraufie, P.1    Dore, J.2    Lapaque, N.3    Blottiere, H.M.4
  • 100
    • 84858376593 scopus 로고    scopus 로고
    • The impact of the gut microbiota on human health: An integrative view
    • Clemente, J.C.; Ursell, L.K.; Parfrey, L.W.; Knight, R. The impact of the gut microbiota on human health: An integrative view. Cell 2012, 148, 1258–1270. [CrossRef] [PubMed]
    • (2012) Cell , vol.148 , pp. 1258-1270
    • Clemente, J.C.1    Ursell, L.K.2    Parfrey, L.W.3    Knight, R.4
  • 101
    • 78650408264 scopus 로고    scopus 로고
    • Diet, gut microbiota and immune responses
    • Maslowski, K.M.; Mackay, C.R. Diet, gut microbiota and immune responses. Nat. Immunol. 2011, 12, 5–9. [CrossRef] [PubMed]
    • (2011) Nat. Immunol. , vol.12 , pp. 5-9
    • Maslowski, K.M.1    Mackay, C.R.2
  • 104
    • 58149466868 scopus 로고    scopus 로고
    • Oxidative and inflammatory pathways in Parkinson’s disease
    • Miller, R.L.; James-Kracke, M.; Sun, G.Y.; Sun, A.Y. Oxidative and inflammatory pathways in Parkinson’s disease. Neurochem. Res. 2009, 34, 55–65. [CrossRef] [PubMed]
    • (2009) Neurochem. Res. , vol.34 , pp. 55-65
    • Miller, R.L.1    James-Kracke, M.2    Sun, G.Y.3    Sun, A.Y.4
  • 105
    • 84921434959 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging—Impact of bcl-2 and npd-1 like metabolites
    • Afshordel, S.; Hagl, S.; Werner, D.; Rohner, N.; Kogel, D.; Bazan, N.G.; Eckert, G.P. Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging—Impact of bcl-2 and npd-1 like metabolites. Prostaglandins Leukot. Essent. Fatty Acids 2015, 92, 23–31. [CrossRef] [PubMed]
    • (2015) Prostaglandins Leukot. Essent. Fatty Acids , vol.92 , pp. 23-31
    • Afshordel, S.1    Hagl, S.2    Werner, D.3    Rohner, N.4    Kogel, D.5    Bazan, N.G.6    Eckert, G.P.7
  • 106
    • 79960533372 scopus 로고    scopus 로고
    • Docosahexaenoic acid signalolipidomics in nutrition: Significance in aging, neuroinflammation, macular degeneration, alzheimer’s, and other neurodegenerative diseases
    • Bazan, N.G.; Molina, M.F.; Gordon, W.C. Docosahexaenoic acid signalolipidomics in nutrition: Significance in aging, neuroinflammation, macular degeneration, alzheimer’s, and other neurodegenerative diseases. Ann. Rev. Nutr. 2011, 31, 321–351. [CrossRef] [PubMed]
    • (2011) Ann. Rev. Nutr. , vol.31 , pp. 321-351
    • Bazan, N.G.1    Molina, M.F.2    Gordon, W.C.3
  • 108
    • 84964601654 scopus 로고    scopus 로고
    • Mechanisms for the activation of toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid
    • Hwang, D.H.; Kim, J.A.; Lee, J.Y. Mechanisms for the activation of toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid. Eur. J. Pharmacol. 2016, 785, 24–35. [CrossRef] [PubMed]
    • (2016) Eur. J. Pharmacol. , vol.785 , pp. 24-35
    • Hwang, D.H.1    Kim, J.A.2    Lee, J.Y.3
  • 109
    • 77649209729 scopus 로고    scopus 로고
    • Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids
    • Lee, J.Y.; Zhao, L.; Hwang, D.H. Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids. Nutr. Rev. 2010, 68, 38–61. [CrossRef] [PubMed]
    • (2010) Nutr. Rev. , vol.68 , pp. 38-61
    • Lee, J.Y.1    Zhao, L.2    Hwang, D.H.3
  • 110
    • 84866514986 scopus 로고    scopus 로고
    • Inhibition of tlr ligand-and interferon gamma-induced murine microglial activation by panax notoginseng
    • Beamer, C.A.; Shepherd, D.M. Inhibition of tlr ligand-and interferon gamma-induced murine microglial activation by panax notoginseng. J. Neuroimmune Pharmacol. 2012, 7, 465–476. [CrossRef] [PubMed]
    • (2012) J. Neuroimmune Pharmacol. , vol.7 , pp. 465-476
    • Beamer, C.A.1    Shepherd, D.M.2
  • 111
    • 85047089793 scopus 로고    scopus 로고
    • Silymarin prevents apoptosis through inhibiting the bax/caspase-3 expression and suppresses toll like receptor-4 pathway in the snc of 6-ohda intoxicated rats
    • Haddadi, R.; Nayebi, A.M.; Eyvari Brooshghalan, S. Silymarin prevents apoptosis through inhibiting the bax/caspase-3 expression and suppresses toll like receptor-4 pathway in the snc of 6-ohda intoxicated rats. Biomed. Pharmacother. 2018, 104, 127–136. [CrossRef] [PubMed]
    • (2018) Biomed. Pharmacother. , vol.104 , pp. 127-136
    • Haddadi, R.1    Nayebi, A.M.2    Eyvari Brooshghalan, S.3
  • 112
    • 84905675648 scopus 로고    scopus 로고
    • Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic
    • Hill, C.; Guarner, F.; Reid, G.; Gibson, G.R.; Merenstein, D.J.; Pot, B.; Morelli, L.; Canani, R.B.; Flint, H.J.; Salminen, S.; et al. Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 2014, 11, 506–514. [CrossRef] [PubMed]
    • (2014) Nat. Rev. Gastroenterol. Hepatol , vol.11 , pp. 506-514
    • Hill, C.1    Guarner, F.2    Reid, G.3    Gibson, G.R.4    Merenstein, D.J.5    Pot, B.6    Morelli, L.7    Canani, R.B.8    Flint, H.J.9    Salminen, S.10
  • 113
    • 84930929369 scopus 로고    scopus 로고
    • Fate, activity, and impact of ingested bacteria within the human gut microbiota
    • Derrien, M.; van Hylckama Vlieg, J.E. Fate, activity, and impact of ingested bacteria within the human gut microbiota. Trends Microbiol. 2015, 23, 354–366. [CrossRef] [PubMed]
    • (2015) Trends Microbiol , vol.23 , pp. 354-366
    • Derrien, M.1    van Hylckama Vlieg, J.E.2
  • 115
    • 85013287868 scopus 로고    scopus 로고
    • The effects of probiotics on depressive symptoms in humans: A systematic review
    • Wallace, C.J.K.; Milev, R. The effects of probiotics on depressive symptoms in humans: A systematic review. Ann. Gen. Psychiatry 2017, 16, 14. [CrossRef] [PubMed]
    • (2017) Ann. Gen. Psychiatry , vol.16 , pp. 14
    • Wallace, C.J.K.1    Milev, R.2
  • 116
    • 85014094052 scopus 로고    scopus 로고
    • Probiotic treatment reduces depressive-like behaviour in rats independently of diet
    • Abildgaard, A.; Elfving, B.; Hokland, M.; Wegener, G.; Lund, S. Probiotic treatment reduces depressive-like behaviour in rats independently of diet. Psychoneuroendocrinology 2017, 79, 40–48. [CrossRef] [PubMed]
    • (2017) Psychoneuroendocrinology , vol.79 , pp. 40-48
    • Abildgaard, A.1    Elfving, B.2    Hokland, M.3    Wegener, G.4    Lund, S.5
  • 117
    • 85046665507 scopus 로고    scopus 로고
    • Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s disease
    • Sun, M.F.; Shen, Y.Q. Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s disease. Ageing Res. Rev. 2018, 45, 53–61. [CrossRef] [PubMed]
    • (2018) Ageing Res. Rev. , vol.45 , pp. 53-61
    • Sun, M.F.1    Shen, Y.Q.2
  • 118
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of lactobacillus strain regulates emotional behavior and central gaba receptor expression in a mouse via the vagus nerve
    • Bravo, J.A.; Forsythe, P.; Chew, M.V.; Escaravage, E.; Savignac, H.M.; Dinan, T.G.; Bienenstock, J.; Cryan, J.F. Ingestion of lactobacillus strain regulates emotional behavior and central gaba receptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. USA 2011, 108, 16050–16055. [CrossRef] [PubMed]
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 16050-16055
    • Bravo, J.A.1    Forsythe, P.2    Chew, M.V.3    Escaravage, E.4    Savignac, H.M.5    Dinan, T.G.6    Bienenstock, J.7    Cryan, J.F.8
  • 121
    • 84914706074 scopus 로고    scopus 로고
    • The effect of lactobacillus reuteri supplementation in adults with chronic functional constipation: A randomized, double-blind, placebo-controlled trial
    • Ojetti, V.; Ianiro, G.; Tortora, A.; D’Angelo, G.; Di Rienzo, T.A.; Bibbo, S.; Migneco, A.; Gasbarrini, A. The effect of lactobacillus reuteri supplementation in adults with chronic functional constipation: A randomized, double-blind, placebo-controlled trial. J. Gastrointest. Liver Dis. JGLD 2014, 23, 387–391.
    • (2014) J. Gastrointest. Liver Dis. JGLD , vol.23 , pp. 387-391
    • Ojetti, V.1    Ianiro, G.2    Tortora, A.3    D’Angelo, G.4    Di Rienzo, T.A.5    Bibbo, S.6    Migneco, A.7    Gasbarrini, A.8
  • 122
    • 85027283029 scopus 로고    scopus 로고
    • Expert consensus document: The international scientific association for probiotics and prebiotics (isapp) consensus statement on the definition and scope of prebiotics
    • Gibson, G.R.; Hutkins, R.; Sanders, M.E.; Prescott, S.L.; Reimer, R.A.; Salminen, S.J.; Scott, K.; Stanton, C.; Swanson, K.S.; Cani, P.D.; et al. Expert consensus document: The international scientific association for probiotics and prebiotics (isapp) consensus statement on the definition and scope of prebiotics. Nat. Rev. Gastroenterol. Hepatol. 2017, 14, 491–502. [CrossRef] [PubMed]
    • (2017) Nat. Rev. Gastroenterol. Hepatol. , vol.14 , pp. 491-502
    • Gibson, G.R.1    Hutkins, R.2    Sanders, M.E.3    Prescott, S.L.4    Reimer, R.A.5    Salminen, S.J.6    Scott, K.7    Stanton, C.8    Swanson, K.S.9    Cani, P.D.10
  • 123
    • 85081145812 scopus 로고    scopus 로고
    • Nutrition and gastrointestinal health as modulators of Parkinson’s disease
    • Folkerts, G., Garssen, J., Eds.; Springer International Publishing: Cham, Germany
    • Rasmussen, H.E.; Piazza, B.R.; Forsyth, C.B.; Keshavarzian, A. Nutrition and gastrointestinal health as modulators of Parkinson’s disease. In Pharma-Nutrition: An Overview; Folkerts, G., Garssen, J., Eds.; Springer International Publishing: Cham, Germany, 2014; pp. 213–242.
    • (2014) Pharma-Nutrition: An Overview , pp. 213-242
    • Rasmussen, H.E.1    Piazza, B.R.2    Forsyth, C.B.3    Keshavarzian, A.4
  • 124
    • 84887130474 scopus 로고    scopus 로고
    • Prebiotic feeding elevates central brain derived neurotrophic factor, n-methyl-d-aspartate receptor subunits and d-serine
    • Savignac, H.M.; Corona, G.; Mills, H.; Chen, L.; Spencer, J.P.; Tzortzis, G.; Burnet, P.W. Prebiotic feeding elevates central brain derived neurotrophic factor, n-methyl-d-aspartate receptor subunits and d-serine. Neurochem. Int. 2013, 63, 756–764. [CrossRef] [PubMed]
    • (2013) Neurochem. Int. , vol.63 , pp. 756-764
    • Savignac, H.M.1    Corona, G.2    Mills, H.3    Chen, L.4    Spencer, J.P.5    Tzortzis, G.6    Burnet, P.W.7
  • 125
    • 84947491451 scopus 로고    scopus 로고
    • The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease
    • Barboza, J.L.; Okun, M.S.; Moshiree, B. The treatment of gastroparesis, constipation and small intestinal bacterial overgrowth syndrome in patients with Parkinson’s disease. Expert Opin. Pharmacother. 2015, 16, 2449–2464. [CrossRef] [PubMed]
    • (2015) Expert Opin. Pharmacother. , vol.16 , pp. 2449-2464
    • Barboza, J.L.1    Okun, M.S.2    Moshiree, B.3
  • 126
    • 85012014046 scopus 로고    scopus 로고
    • Gut microbiota: Implications in Parkinson’s disease
    • Parashar, A.; Udayabanu, M. Gut microbiota: Implications in Parkinson’s disease. Parkinsonism Relat. Disord. 2017, 38, 1–7. [CrossRef] [PubMed]
    • (2017) Parkinsonism Relat. Disord. , vol.38 , pp. 1-7
    • Parashar, A.1    Udayabanu, M.2
  • 127
    • 84987802575 scopus 로고    scopus 로고
    • Modulation of intestinal tlr4-inflammatory signaling pathways by probiotic microorganisms: Lessons learned from lactobacillus jensenii tl2937
    • Villena, J.; Kitazawa, H. Modulation of intestinal tlr4-inflammatory signaling pathways by probiotic microorganisms: Lessons learned from lactobacillus jensenii tl2937. Front. Immunol. 2014, 4, 512. [CrossRef] [PubMed]
    • (2014) Front. Immunol. , vol.4 , pp. 512
    • Villena, J.1    Kitazawa, H.2
  • 128
    • 79952923925 scopus 로고    scopus 로고
    • Eritoran tetrasodium (E5564) treatment for sepsis: Review of preclinical and clinical studies
    • Barochia, A.; Solomon, S.; Cui, X.; Natanson, C.; Eichacker, P.Q. Eritoran tetrasodium (e5564) treatment for sepsis: Review of preclinical and clinical studies. Expert Opin. Drug Metab. Toxicol. 2011, 7, 479–494. [CrossRef] [PubMed]
    • (2011) Expert Opin. Drug Metab. Toxicol. , vol.7 , pp. 479-494
    • Barochia, A.1    Solomon, S.2    Cui, X.3    Natanson, C.4    Eichacker, P.Q.5
  • 129
    • 85026461615 scopus 로고    scopus 로고
    • The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the mptp model of Parkinson’s disease
    • Schwenkgrub, J.; Zaremba, M.; Joniec-Maciejak, I.; Cudna, A.; Mirowska-Guzel, D.; Kurkowska-Jastrzebska, I. The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the mptp model of Parkinson’s disease. PLoS ONE 2017, 12, e0182019. [CrossRef] [PubMed]
    • (2017) Plos ONE , vol.12
    • Schwenkgrub, J.1    Zaremba, M.2    Joniec-Maciejak, I.3    Cudna, A.4    Mirowska-Guzel, D.5    Kurkowska-Jastrzebska, I.6
  • 130
    • 85014869477 scopus 로고    scopus 로고
    • Butyrate induces ros-mediated apoptosis by modulating mir-22/sirt-1 pathway in hepatic cancer cells
    • Pant, K.; Yadav, A.K.; Gupta, P.; Islam, R.; Saraya, A.; Venugopal, S.K. Butyrate induces ros-mediated apoptosis by modulating mir-22/sirt-1 pathway in hepatic cancer cells. Redox Biol. 2017, 12, 340–349. [CrossRef] [PubMed]
    • (2017) Redox Biol , vol.12 , pp. 340-349
    • Pant, K.1    Yadav, A.K.2    Gupta, P.3    Islam, R.4    Saraya, A.5    Venugopal, S.K.6
  • 131
    • 85042382178 scopus 로고    scopus 로고
    • Gut microbiota: An integral moderator in health and disease
    • Feng, Q.; Chen, W.D.; Wang, Y.D. Gut microbiota: An integral moderator in health and disease. Front. Microbiol. 2018, 9, 151. [CrossRef] [PubMed]
    • (2018) Front. Microbiol. , vol.9 , pp. 151
    • Feng, Q.1    Chen, W.D.2    Wang, Y.D.3
  • 134
    • 85048306388 scopus 로고    scopus 로고
    • Neuroprotective effect of docosahexaenoic acid in rat traumatic brain injury model via regulation of tlr4/nf-kappa b signaling pathway
    • Tang, R.; Lin, Y.M.; Liu, H.X.; Wang, E.S. Neuroprotective effect of docosahexaenoic acid in rat traumatic brain injury model via regulation of tlr4/nf-kappa b signaling pathway. Int. J. Biochem. Cell Biol. 2018, 99, 64–71. [CrossRef] [PubMed]
    • (2018) Int. J. Biochem. Cell Biol. , vol.99 , pp. 64-71
    • Tang, R.1    Lin, Y.M.2    Liu, H.X.3    Wang, E.S.4
  • 135
    • 69949140723 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Kumar, H.; Kawai, T.; Akira, S. Toll-like receptors and innate immunity. Biochem. Biophys. Res. Commun. 2009, 388, 621–625. [CrossRef] [PubMed]
    • (2009) Biochem. Biophys. Res. Commun. , vol.388 , pp. 621-625
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 136
    • 84956776076 scopus 로고    scopus 로고
    • The piglet as a model for studying dietary components in infant diets: Effects of galacto-oligosaccharides on intestinal functions
    • Alizadeh, A.; Akbari, P.; Difilippo, E.; Schols, H.A.; Ulfman, L.H.; Schoterman, M.H.; Garssen, J.; Fink-Gremmels, J.; Braber, S. The piglet as a model for studying dietary components in infant diets: Effects of galacto-oligosaccharides on intestinal functions. Br. J. Nutr. 2016, 115, 605–618. [CrossRef] [PubMed]
    • (2016) Br. J. Nutr. , vol.115 , pp. 605-618
    • Alizadeh, A.1    Akbari, P.2    Difilippo, E.3    Schols, H.A.4    Ulfman, L.H.5    Schoterman, M.H.6    Garssen, J.7    Fink-Gremmels, J.8    Braber, S.9
  • 137
    • 84980335892 scopus 로고    scopus 로고
    • Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut
    • Riviere, A.; Selak, M.; Lantin, D.; Leroy, F.; De Vuyst, L. Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut. Front. Microbiol. 2016, 7, 979. [CrossRef] [PubMed]
    • (2016) Front. Microbiol. , vol.7 , pp. 979
    • Riviere, A.1    Selak, M.2    Lantin, D.3    Leroy, F.4    de Vuyst, L.5


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