Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce

European Journal of Immunology

Volumn 43, Issue 8, 2013, Pages 2114-2125

  Yáñez, Alberto ^a   Hassanzadeh Kiabi, Nargess ^a   Ng, Madelena Y ^a   Megías, Javier ^b   Subramanian, Aparna ^a   Liu, George Y ^a,c   Underhill, David M ^a,c   Gil, M Luisa ^b   Goodridge, Helen S ^a,c  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hematopoietic progenitor cells; Hematopoietic stem cells; Monocytes macrophages; Myelopoiesis; TLRs

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; MYELOPOIESIS; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL;

HEMATOPOIETIC PROGENITOR CELLS; HEMATOPOIETIC STEM CELLS; MONOCYTES/ MACROPHAGES; MYELOPOIESIS; TLRS;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; HEMATOPOIETIC STEM CELLS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPEPTIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID CELLS; MYELOPOIESIS; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84881510716     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343403     Document Type: Article

References (32)

1. Netea, M. G., Quintin, J. and van der Meer, J. W., Trained immunity: a memory for innate host defense. Cell Host Microbe. 2011. 9: 355-361.
2. Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A., Ifrim, D. C., Saeed, S., Jacobs, C. et al., Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes. Proc. Natl. Acad. Sci. USA 2012. 109: 17537-17542.
3. Quintin, J., Saeed, S., Martens, J. H., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L. et al., Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe. 2012. 12: 223-232.
4. King, K. Y. and Goodell, M. A., Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat. Rev. Immunol. 2011. 11: 685-692.
5. Nagai, Y., Garrett, K. P., Ohta, S., Bahrun, U., Kouro, T., Akira, S., Takatsu, K. et al., Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 2006. 24: 801-812.
6. + progenitor cells along the myeloid lineage. J. Mol. Biol. 2006. 364: 945-954.
7. Massberg, S., Schaerli, P., Knezevic-Maramica, I., Kollnberger, M., Tubo, N., Moseman, E. A., Huff, I. V. et al., Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 2007. 131: 994-1008.
8. Megias, J., Yanez, A., Moriano, S., O'Connor, J. E., Gozalbo, D. and Maria Luisa Gil, Direct toll like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation towards macrophages. Stem Cells 2012. 30: 1486-1495.
9. + DC capable of inducing a Th1-type response. Eur. J. Immunol. 2007. 37: 2834-2846.
10. Welner, R. S., Pelayo, R., Nagai, Y., Garrett, K. P., Wuest, T. R., Carr, D. J., Borghesi, L. A. et al., Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood 2008. 112: 3753-3761.
11. Yanez, A., Flores, A., Murciano, C., O'Connor, J. E., Gozalbo, D. and Maria Luisa Gil, Signalling through TLR2/MyD88 induces differentiation of murine bone marrow stem and progenitor cells to functional phagocytes in response to Candida albicans. Cell Microbiol. 2010. 12: 114-128.
12. Yanez, A., Megias, J., O'Connor, J. E., Gozalbo, D. and Maria Luisa Gil, Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling. PLoS One 2011. 6: e24761.
13. Yanez, A., Murciano, C., O'Connor, J. E., Gozalbo, D. and Maria Luisa Gil, Candida albicans triggers proliferation and differentiation of hematopoietic stem and progenitor cells by a MyD88-dependent signaling. Microbes. Infect. 2009. 11: 531-535.
14. Megias, J., Maneu, V., Salvador, P., Gozalbo, D. and Maria Luisa Gil, Candida albicans stimulates in vivo differentiation of haematopoietic stem and progenitor cells towards macrophages by a TLR2-dependent signalling. Cell Microbiol. 2013. 15: 1143-1153. DOI: 10.1111/cmi.12104.
15. Clarke, T. B., Davis, K. M., Lysenko, E. S., Zhou, A. Y., Yu, Y. and Weiser, J. N., Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat. Med. 2010. 16: 228-231.
16. Shi, C., Jia, T., Mendez-Ferrer, S., Hohl, T. M., Serbina, N. V., Lipuma, L., Leiner, I. et al., Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity 2011. 34: 590-601.
17. Mazo, I. B., Massberg, S. and von Andrian, U. H., Hematopoietic stem and progenitor cell trafficking. Trends Immunol. 2011. 32: 493-503.
18. Biswas, S. K. and Lopez-Collazo, E., Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 2009. 30: 475-487.
19. Medvedev, A. E., Sabroe, I., Hasday, J. D. and Vogel, S. N., Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J. Endotoxin. Res. 2006. 12: 133-150.
20. Foster, S. L., Hargreaves, D. C. and Medzhitov, R., Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007. 447: 972-978.
21. Pabst, M. J. and Johnston, R. B., Jr., Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide. J. Exp. Med. 1980. 151: 101-114.
22. Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S. and Underhill, D. M., Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J. Exp. Med. 2003. 197: 1107-1117.
23. Esplin, B. L., Shimazu, T., Welner, R. S., Garrett, K. P., Nie, L., Zhang, Q., Humphrey, M. B. et al., Chronic exposure to a TLR ligand injures hematopoietic stem cells. J. Immunol. 2011. 186: 5367-5375.
24. Mahbub, S., Brubaker, A. L. and Kovacs, E. J., Aging of the innate immune system: an update. Curr. Immunol. Rev. 2011. 7: 104-115.
25. Goulding, J., Snelgrove, R., Saldana, J., Didierlaurent, A., Cavanagh, M., Gwyer, E., Wales, J. et al., Respiratory infections: do we ever recover? Proc. Am. Thorac. Soc. 2007. 4: 618-625.
26. Didierlaurent, A., Goulding, J., Patel, S., Snelgrove, R., Low, L., Bebien, M., Lawrence, T. et al., Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J. Exp. Med. 2008. 205: 323-329.
27. Goodridge, H. S., Marshall, F. A., Wilson, E. H., Houston, K. M., Liew, F. Y., Harnett, M. M. and Harnett, W., In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype. Immunology 2004. 113: 491-498.
28. Harnett, W. and Harnett, M. M., Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62. Adv. Exp. Med. Biol. 2009. 666: 88-94.
29. Goodridge, H. S., Marshall, F. A., Else, K. J., Houston, K. M., Egan, C., Al-Riyami, L., Liew, F. Y. et al., Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62. J. Immunol. 2005. 174: 284-293.
30. Goodridge, H. S., McGuiness, S., Houston, K. M., Egan, C. A., Al-Riyami, L., Alcocer, M. J., Harnett, M. M. and Harnett, W., Phosphorylcholine mimics the effects of ES-62 on macrophages and dendritic cells. Parasite Immunol. 2007. 29: 127-137.
31. Buechler, M. B., Teal, T. H., Elkon, K. B. and Hamerman, J. A., Cutting edge: type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling. J. Immunol. 2013. 190: 886-891.
32. Underhill, D. M., Rossnagle, E., Lowell, C. A. and Simmons, R. M., Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 2005. 106: 2543-2550.