Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Cell

Volumn 167, Issue 6, 2016, Pages 1469-1480.e12

  Sampson, Timothy R ^a   Debelius, Justine W ^b   Thron, Taren ^a   Janssen, Stefan ^b   Shastri, Gauri G ^a   Ilhan, Zehra Esra ^c   Challis, Collin ^a   Schretter, Catherine E ^a   Rocha, Sandra ^d   Gradinaru, Viviana ^a   Chesselet, Marie Francoise ^e   Keshavarzian, Ali ^f   Shannon, Kathleen M ^f   Krajmalnik Brown, Rosa ^c   Wittung Stafshede, Pernilla ^d   Knight, Rob ^b,g   Mazmanian, Sarkis K ^a  

^a California Institute of Technology   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

^d CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f RUSH UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

gut brain axis; microbiome; microglia; mouse model; Parkinson's disease; short chain fatty acids; synuclein

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; ALPHA SYNUCLEIN; FATTY ACID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL COLONIZATION; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DYSBIOSIS; FECES MICROFLORA; GENE OVEREXPRESSION; HUMAN; INTESTINE FLORA; MICROGLIA; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; GASTROINTESTINAL TRACT; INFLAMMATION; METABOLISM; MICROBIOLOGY; PATHOLOGY; PATHOPHYSIOLOGY;

ALPHA-SYNUCLEIN; ANIMALS; BRAIN; DYSBIOSIS; FATTY ACIDS; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; HUMANS; INFLAMMATION; MICE; MICROGLIA; PARKINSON DISEASE;

EID: 85001930733     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.11.018     Document Type: Article

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