Influence of capsaicin-sensitive afferent neurons and nitric oxide (NO) on cerulein-induced pancreatitis in rats

International Journal of Pancreatology

Volumn 19, Issue 3, 1996, Pages 179-189

  Dembinski, Artur ^a   Warzecha, Zygmunt ^a   Konturek, Piotr J ^b   Ceranowicz, Piotr ^a   Konturek, Stanislaw J ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Capsaicin; cerulein; DNA content; DNA synthesis; nitric oxide; pancreatitis

Indexed keywords

AMYLASE; ARGININE; CAPSAICIN; CERULETIDE; NITRIC OXIDE;

AMYLASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA CONTENT; DNA SYNTHESIS; LEUKOCYTE ADHERENCE; MALE; NEUROTOXICITY; NEUTROPHIL; NONHUMAN; PANCREAS BLOOD FLOW; PANCREATITIS; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; RNA ANALYSIS; SENSORY NERVE; TISSUE INJURY;

ANIMALS; ARGININE; CAERULEIN; CAPSAICIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MALE; NEURONS, AFFERENT; NITRIC OXIDE; NITROARGININE; PANCREAS; PANCREATITIS; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW;

EID: 0029953255     PISSN: 01694197     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Szolesanyi J, Bartho L. Impaired defense mechanism to peptic ulcer in the capsaicin-desensitized rat, in Gastrointestinal Defense Mechanisms, Mowik G, Hanuinen O, Javor T, eds. Pergamon and Akademiai Kidao, Oxford and Budapest, 1981; pp. 39-51.
2. Buck SH, Burks TF. The neuropharmacology of capsaicin: Review of some recent observations. Pharmacol Rev 1986; 38: 179-226.
3. Holzer P, Livingston EH, Guth PH. Sensory neurons signal for an increase in gastric mucosal blood flow in the face of pendium acid injury. Gastroenterology 1991; 101: 416-423.
4. Matsumoto J, Takeuchi K, Okabe S. Characterization of gastric mucosal blood flow response induced by intragastric capsaicin in rats. Jpn J Pharmacol 1991; 57: 205-213.
5. Holzer P, Lippe IP. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol induced damage of gastric mucosa. Neuroscience 1988; 27: 981-987.
6. Holzer P, Pabst MA, Lippe ITH, Peskar BM, Peskar BA, Livingstone EH, Guth PH. Afferent nerve-mediated protection against deep mucosal damage in the rat stomach. Gastroenterologe 1990; 98: 838-848.
7. Yoney Y, Holzer P, Guth PH. Laparatomy-induced gastric protection against ethanol injury is mediated by capsaicin-sensitive sensory neurons. Gastroenterology 1990; 99: 3-9.
8. Espluges JV, Whittle BJR, Moncada S. Local opioidsensitive afferent sensory neurons in the modulation of gastric damage by PAF. Br J Pharmacol 1989; 97: 579-585.
9. Takeuchi K, Ueshima K, Ohuchi T, Okabe S. The role of capsaicin-sensitive sensory neurons in healing of HC1-induced gastric mucosal lesions in rats. Gastroenterology 1994; 106: 1524-1532.
10. Brzozowski T, Drozdowicz D, Szlachcic A, Pytko-Polonezyk J, Majka J, Konturek SJ. Role of nitric oxide and prostaglandins in gastroprotection induced by capsaicin and papaverine. Digestion 1993; 54: 24-31.
11. Beijer HJM, Mass AHJ, Charbon GA. A vasopressin decrease in pancreatic blood flow and in pancreatic exocrine secretion in anaesthetized dog. Pflugers Arch 1984; 400: 324-328.
12. Gicquel N, Nagain C, Chariot J, Tsocas A, Levenez F, Corring T, Roze C. Modulation of pancreatic secretion by capsaicin-sensitive sensory neurons in the rat. Pancreas 1994; 9: 203-211.
13. Palmer RMJ, Ferriga AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived releasing factor. Nature 1987; 327: 524-526.
14. MacNaughton WK, Cirino G, Wallace JL. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci 1989; 45: 1869-1876.
15. Peskar BM, Respondek M, Muller KM, Peskar BA. A role for nitric oxide in capsaicin-induced gastroprotection. Eur J Pharmacol 1991; 198: 113,114.
16. Whittle BJR, Lopez-Belmonte J, Moncada S. Nitric oxide mediates rat mucosal vasodilatation induced by intragastric capsaicin. Eur J Pharmacol 1992; 218: 339-341.
17. Konturek SJ, Bilski J, Konturek PK, Cieszkowski M, Pawlik W. Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow. Gastroenterology 1993; 104: 896-912.
18. Waldner H. Vascular mechanisms to induce acute pancreatitis. Eur Surg Res 1992; 24, Suppl: 62-67.
19. Konturek SJ, Dembinski A, Konturek PJ, Warzecha Z, Jaworek J, Gustaw P, Tomaszewska R, Stachura J. Role of platelet activating factor in pathogenesis of acute pancreatitis in rats. Gut 1992; 33: 1268-1274.
20. Konturek SJ, Szlacheic A, Dembinski A, Warzecha Z, Jaworek J, Stachura J. Nitric oxide in pancreatic secretion and hormone-induced pancreatitis in rats. Int J Pancreatol 1994; 15: 19-28.
21. Jungi TW, Spycher MO, Nydegger UE, Barandum S. Platelet-leukocyte interaction: selective binding of thrombin stimulated platelets of human monocytes, polymorphonuclear leukocytes and related cell lanes. Blood 1986; 77: 629-635.
22. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation and sedimentation at 1 g. J Clin Lab Invest 1968; 21, Suppl 97: 77-82.
23. Hsu-Lin SC, Berman CL, Furie BC, August D, Furie B. A platelet membrane protein expressed during platelet activation. J Biol Chem 1984; 259: 9121-9126.
24. Ceriotti G. Determination of nucleic acids in animal tissue. J Biol Chem 1955; 214: 59-65.
25. Giles KW, Myers A. An improvement diphenylamine method for the estimation of deoxyribonucleic acid. Nature 1965; 206: 93.
26. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951; 193: 265-275.
27. Maggi CA, Evangelista S, Abelli L, Somma V, Melt A. Capsaicin-sensitive mechanism and experimentally induced duodenal ulcer in rats. J Pharm Pharmacol 1987; 39: 559-561.
28. Takeuchi K, Matsumoto J, Ueshima K, Okabe S. Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum. Gastroenterology 1991; 101: 954-961.
29. De Giorgio R, Sternini C, Widdison AL, Alvarez C, Brecha NC, Reber HA, Go VL. Differential effects of experimentally induced chronic pancreatitis on neuropeptide immunoreactivities in the feline pancreas. Pancreas 1993; 8: 700-710.
30. Li Y, Kolligs F, Owyang C. Mechanism of action of calcitonin gene-related peptide in inhibiting pancreatic enzyme secretion in rats. Gastroenterology 1993; 105: 194-201.
31. Li DS, Raybould HE, Quintero E, Guth PH. Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin. Am J Physiol 1991; 261: G657-G661.
32. Holzer P. Local effecter functions of capsaicin sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988; 24: 739-768.
33. Ren J, Yong RL, Lassiter DS, Lassiter DS, Harty RR. Calcitonin gene-related peptide mediates capsaicin-induced neuroendocrine responses in rat antrum. Gastroenterology 1993; 104: 485-491.
34. Holzer P, Pescar BA, Amann R. Release of calcitonin gene-related peptide induced by capsaicin in the vasculatory perfused rat stomach. Neurosci Lett 1990; 180: 195-200.
35. Holzer P, Guth PH. Neuropeptide control of rat gastric mucosal blood flow. Circ Res 1991; 68: 100-105.
36. Huges SR, Brain SD. Nitric oxide dependent release of vasodilator quantities of calcitonin gene-related peptide from nerves in rabbit skin. Br J Pharmacol 1994; 111: 425-430.
37. Wilamalawansa SJ. The effects of neonatal capsaicin on plasma levels and tissue contents of CGRP. Peptides 1993; 14: 247-252.
38. Messmer B, Zimmerman FG, Lenz HJ. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic and adrenergic pathways. Am J Physiol 1993; 264: G237-G242.
39. Debas HT, Nelson MT, Bunnett NW, Mulvihill SJ. Selective release of somatostatin by calcitonin gene-related peptide and influence on pancreatic secretion. Ann NY Acad Sci 1992; 657: 289-298.
40. Garry MG, Richardson JD, Hargreaves KM. Sodium nitroprusside evokes the release of immunoreactive calcitonin gene-related peptide and substance P from dorsal horn slices via nitric oxide-dependent and nitric oxide-independent mechanisms. J Neurosci 1994; 14: 4329-4337.
41. Kline LW, Pang PK. Nitric oxide modulates the calcitonin gene-related peptide-induced relaxation in guinea pig gallbladder strips in vitro. Regul Pept 1994; 50: 207-212.
42. Clementi G, Caruso A, Prato A, De Bernardis E, Fiore CE, Amico-Roxas M. A role for nitric oxide in the anti-ulcer activity of calcitonin gene-related peptide. Eur J Pharmacol 1994; 256: R7-8.
43. Wallace JL. Non-steroidal antiinflammatory drug gastropathy and cytoprotection. Pathogenesis and mechanisms re-examined. Scand J Gastroenterol 1992; 27, Suppl 192: 3-8.
44. Guth PH. Current concept in gastric microcirculatory pathophysiology. Yale J Biol Med 1992; 65: 677-688.
45. Chavez-Cataya RE, Metcalfe S, Ramirez-Romero P, Calne R, Jamieson NV. Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing of circulating leukocytes. Transplantation 1994; 57: 1440-1444.
46. Lippe IT, Sametz W, Sabin K, Holzer P. Inhibitory role of capsaicin-sensitive afferent neurons and nitric oxide in hemostasis. Am J Physiol 1993; 265; H1864-H1868.
47. Provost P, Lam JY, Lacoste L, Merhi Y, Waters D. Endothelium-derived nitric oxide attenuates neutrophil adhesion to endothelium under arterial flow condition. Arteriosclerosis Thromb 1994; 14: 331-335.