Gut microbiota: An integral moderator in health and disease

Frontiers in Microbiology

Volumn 9, Issue FEB, 2018, Pages

  Feng, Qingqing ^a   Chen, Wei Dong ^b,c   Wang, Yan Dong ^a  

^a BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^b HENAN UNIVERSITY   (China)

^c INNER MONGOLIA MEDICAL UNIVERSITY   (China)

Author keywords

Gut microbiota; Intestinal disease; Liver disease; Lung; MiRNA

Indexed keywords

AMYLOID; LIPOPOLYSACCHARIDE; MICRORNA; SHORT CHAIN FATTY ACID; T LYMPHOCYTE RECEPTOR;

ADAPTIVE IMMUNITY; ALCOHOL LIVER DISEASE; ALZHEIMER DISEASE; COLORECTAL CANCER; DYSPEPSIA; GENE INTERACTION; HEALTH; HUMAN; INNATE IMMUNITY; INTESTINE FLORA; IRRITABLE COLON; LIVER CELL CARCINOMA; LIVER DISEASE; NONALCOHOLIC FATTY LIVER; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 85042382178     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2018.00151     Document Type: Short Survey

References (78)

1. Arrieta, M. C., Stiemsma, L. T., Dimitriu, P. A., Thorson, L., Russell, S., Yuristdoutsch, S., et al. (2015). Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med. 7:307ra152. doi: 10.1126/scitranslmed.aab2271
2. Bakker, A. D., Gakes, T., Hogervorst, J. M., De Wit, G. M., Klein-Nulend, J., and Jaspers, R. T. (2016). Mechanical stimulation and IGF-1 enhance mRNA translation rate in osteoblasts via activation of the AKT-mTOR pathway. J. Cell. Physiol. 231, 1283-1290. doi: 10.1002/jcp.25228
3. Barrett, E., Ross, R. P., O'toole, P. W., Fitzgerald, G. F., and Stanton, C. (2012). Aminobutyric acid production by culturable bacteria from the human intestine. J. Appl. Microbiol. 113, 411-417. doi: 10.1111/j.1365-2672.2012.05344.x
4. Baruch, K., and Schwartz, M. (2016). Circulating monocytes in between the gut and the mind. Cell Stem Cell 18, 689-691. doi: 10.1016/j.stem.2016.05.008
5. Belcheva, A. (2017). MicroRNAs at the epicenter of intestinal homeostasis. Bioessays 39. doi: 10.1002/bies.201600200
6. Betrapally, N. S., Gillevet, P. M., and Bajaj, J. S. (2017). Gut microbiome and liver disease. Transl. Res. 179, 49-59. doi: 10.1016/j.trsl.2016.07.005
7. Britton, R. A., Irwin, R., Quach, D., Schaefer, L., Zhang, J., Lee, T., et al. (2014). Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J. Cell. Physiol. 229, 1822-1830. doi: 10.1002/jcp.24636
8. Budden, K. F., Gellatly, S. L., Wood, D. L., Cooper, M. A., Morrison, M., Hugenholtz, P., et al. (2017). Emerging pathogenic links between microbiota and the gut-lung axis. Nat. Rev. Microbiol. 15, 55-63. doi: 10.1038/nrmicro.2016.142
9. Bultman, S. J. (2017). Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer. Mol. Nutr. Food Res. 61. doi: 10.1002/mnfr.201500902
10. Buret, A. G. (2016). Good bugs, bad bugs in the gut: the role of microbiota dysbiosis in chronic gastrointestinal consequences of infection. Am. J. Gastroenterol. Suppl. 3, 25-32. doi: 10.1038/ajgsup.2016.11
11. Chiang, J. Y. (2013). Bile acid metabolism and signaling. Compr. Physiol. 3, 1191-1212. doi: 10.1002/cphy.c120023
12. Chin, A. R., Fong, M. Y., Somlo, G., Wu, J., Swiderski, P., Wu, X., et al. (2016). Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res. 26, 217-228. doi: 10.1038/cr.2016.13
13. De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., et al. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc. Natl. Acad. Sci. U.S.A. 107, 14691-14696. doi: 10.1073/pnas.1005963107
14. Dinan, T. G., and Cryan, J. F. (2017). Gut-brain axis in 2016: brain-gut-microbiota axis-mood, metabolism and behaviour. Nat. Rev. Gastroenterol. Hepatol. 14, 69-70. doi: 10.1038/nrgastro.2016.200
15. Donohoe, D., Garge, N., Zhang, X., Sun, W., O'connell, T., Bunger, M., et al. (2011). The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab. 13, 517-526. doi: 10.1016/j.cmet.2011.02.018
16. Farrokhyar, F., Swarbrick, E. T., and Irvine, E. J. (2001). A critical review of epidemiological studies in inflammatory bowel disease. Scand. J. Gastroenterol. 36, 2-15
17. Foster, J. A., and McVey Neufeld, K. A. (2013). Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 36, 305-312. doi: 10.1016/j.tins.2013.01.005
18. Fung, K. Y., Cosgrove, L., Lockett, T., Head, R., and Topping, D. L. (2012). A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate. Br. J. Nutr. 108, 820-831. doi: 10.1017/S0007114512001948
19. Fung, T. C., Olson, C. A., and Hsiao, E. Y. (2017). Interactions between the microbiota, immune and nervous systems in health and disease. Nat. Neurosci. 20, 145-155. doi: 10.1038/nn.4476
20. Gao, Z., Guo, B., Gao, R., Zhu, Q., and Qin, H. (2015). Microbiota disbiosis is associated with colorectal cancer. Front. Microbiol. 6:20. doi: 10.3389/fmicb.2015.00020
21. Gerbe, F., Legraverend, C., and Jay, P. (2012). The intestinal epithelium tuft cells: specification and function. Cell Mol. Life Sci. 69, 2907-2917. doi: 10.1007/s00018-012-0984-7
22. Gray, J., Oehrle, K., Worthen, G., Alenghat, T., Whitsett, J., and Deshmukh, H. (2017). Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Sci. Transl. Med. 9:eaaf9412. doi: 10.1126/scitranslmed.aaf9412
23. Gray, L. E., O'hely, M., Ranganathan, S., Sly, P. D., and Vuillermin, P. (2017). The maternal diet, gut bacteria, and bacterial metabolites during pregnancy influence offspring asthma. Front. Immunol. 8:365. doi: 10.3389/fimmu.2017.00365
24. Holmes, E., Li, J. V., Athanasiou, T., Ashrafian, H., and Nicholson, J. K. (2011). Understanding the role of gut microbiome-host metabolic signal disruption in health and disease. Trends Microbiol. 19, 349-359. doi: 10.1016/j.tim.2011.05.006
25. Iorio, M. V., Ferracin, M., Liu, C. G., Veronese, A., Spizzo, R., Sabbioni, S., et al. (2005). MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65, 7065-7070. doi: 10.1158/0008-5472.CAN-05-1783
26. Karbach, S. H., Schonfelder, T., Brandao, I., Wilms, E., Hormann, N., Jackel, S., et al. (2016). Gut microbiota promote angiotensin II-induced arterial hypertension and vascular dysfunction. J. Am. Heart Assoc. 5:e003698. doi: 10.1161/JAHA.116.003698
27. Kennedy, P. J., Cryan, J. F., Dinan, T. G., and Clarke, G. (2017). Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology 112, 399-412. doi: 10.1016/j.neuropharm.2016.07.002
28. Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., et al. (2014). Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med. 6:107. doi: 10.1186/s13073-014-0107-1
29. Köhler, C. A., Maes, M., Slyepchenko, A., Berk, M., Solmi, M., Lanctôt, K. L., et al. (2016). The gut-brain axis, including the microbiome, leaky gut and bacterial translocation: mechanisms and pathophysiological role in Alzheimer's disease. Curr. Pharmaceut. Design 22, 6152-6166. doi: 10.2174/1381612822666160907093807
30. Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., et al. (2013). Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14, 207-215. doi: 10.1016/j.chom.2013.07.007
31. Leue, C., Kruimel, J., Vrijens, D., Masclee, A., Van Os, J., and Van Koeveringe, G. (2017). Functional urological disorders: a sensitized defence response in the bladder-gut-brain axis. Nat. Rev. Urol. 14, 153-163. doi: 10.1038/nrurol.2016.227
32. Li, P., Shan, J. X., Chen, X. H., Zhang, D., Su, L. P., Huang, X. Y., et al. (2015). Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment. Cell Res. 25, 588-603. doi: 10.1038/cr.2015.51
33. Li, R., Yang, J., Saffari, A., Jacobs, J., Baek, K. I., Hough, G., et al. (2017). Ambient ultrafine particle ingestion alters gut microbiota in association with increased atherogenic lipid metabolites. Sci. Rep. 7:42906. doi: 10.1038/srep42906
34. Liu, S., Da Cunha, A. P., Rezende, R. M., Cialic, R., Wei, Z., Bry, L., et al. (2016). The host shapes the gut microbiota via fecal microRNA. Cell Host Microbe 19, 32-43. doi: 10.1016/j.chom.2015.12.005
35. Lujambio, A., and Lowe, S. W. (2012). The microcosmos of cancer. Nature 482, 347-355. doi: 10.1038/nature10888
36. Mu, C., Yang, Y., and Zhu, W. (2016). Gut microbiota: the brain peacekeeper. Front. Microbiol. 7:345. doi: 10.3389/fmicb.2016.00345
37. Nakata, K., Sugi, Y., Narabayashi, H., Kobayakawa, T., Nakanishi, Y., Tsuda, M., et al. (2017). Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through a small GTPase ARF4. J. Biol. Chem. 292, 15426-15433. doi: 10.1074/jbc. M117.788596
38. Nicolas, S., Blasco-Baque, V., Fournel, A., Gilleron, J., Klopp, P., Waget, A., et al. (2017). Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Mol. Syst. Biol. 13:921. doi: 10.15252/msb.20167356
39. Ohigashi, S., Sudo, K., Kobayashi, D., Takahashi, O., Takahashi, T., Asahara, T., et al. (2013). Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer. Dig. Dis. Sci. 58, 1717-1726. doi: 10.1007/s10620-012-2526-4
40. Ohlsson, C., Engdahl, C., Fak, F., Andersson, A., Windahl, S. H., Farman, H. H., et al. (2014). Probiotics protect mice from ovariectomy-induced cortical bone loss. PLoS One 9:e92368. doi: 10.1371/journal.pone.0092368
41. Ohlsson, C., and Sjogren, K. (2015). Effects of the gut microbiota on bone mass. Trends Endocrinol. Metab. 26, 69-74. doi: 10.1016/j.tem.2014.11.004
42. O'Keefe, S. J., Ou, J., Aufreiter, S., O'connor, D., Sharma, S., Sepulveda, J., et al. (2009). Products of the colonic microbiota mediate the effects of diet on colon cancer risk. J. Nutr. 139, 2044-2048. doi: 10.3945/jn.109.104380
43. Pant, K., Yadav, A. K., Gupta, P., Islam, R., Saraya, A., and Venugopal, S. K. (2017). Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells. Redox Biol. 12, 340-349. doi: 10.1016/j.redox.2017.03.006
44. Patel, T., Bhattacharya, P., and Das, S. (2016). Gut microbiota: an indicator to gastrointestinal tract diseases. J. Gastrointest. Cancer 47, 232-238. doi: 10.1007/s12029-016-9820-x
45. Peck, B. C., Mah, A. T., Pitman, W. A., Ding, S., Lund, P. K., and Sethupathy, P. (2017). Functional transcriptomics in diverse intestinal epithelial cell types reveals robust microRNA sensitivity in intestinal stem cells to microbial status. J. Biol. Chem. 292, 2586-2600. doi: 10.1074/jbc. M116.770099
46. Powell, N., Walker, M. M., and Talley, N. J. (2017). The mucosal immune system: master regulator of bidirectional gut-brain communications. Nat. Rev. Gastroenterol. Hepatol. 14, 143-159. doi: 10.1038/nrgastro.2016.191
47. Ridler, C. (2017). Bone: gut microbiota promote bone growth via IGF1. Nat. Rev. Endocrinol. 13:5. doi: 10.1038/nrendo.2016.200
48. Roy, S., and Trinchieri, G. (2017). Microbiota: a key orchestrator of cancer therapy. Nat. Rev. Cancer 17, 271-285. doi: 10.1038/nrc.2017.13
49. Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., and Han, Y. W. (2013). Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin. Cell Host Microbe 14, 195-206. doi: 10.1016/j.chom.2013.07.012
50. Rupaimoole, R., and Slack, F. J. (2017). MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat. Rev. Drug Discov. 16, 203-222. doi: 10.1038/nrd.2016.246
51. Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., et al. (2016). Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease. Cell 167, 1469.e12-1480.e12. doi: 10.1016/j.cell.2016.11.018
52. Sayin, S. I., Wahlstrom, A., Felin, J., Jantti, S., Marschall, H. U., Bamberg, K., et al. (2013). Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17, 225-235. doi: 10.1016/j.cmet.2013.01.003
53. Schroeder, B. O., and Backhed, F. (2016). Signals from the gut microbiota to distant organs in physiology and disease. Nat. Med. 22, 1079-1089. doi: 10.1038/nm.4185
54. Schwarzer, M., Makki, K., Storelli, G., Machuca-Gayet, I., Srutkova, D., Hermanova, P., et al. (2016). Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science 351, 854-857. doi: 10.1126/science.aad8588
55. Scott, D. W., Longpre, J. M., and Loo, G. (2008). Upregulation of GADD153 by butyrate: involvement of MAPK. DNA Cell Biol. 27, 607-614. doi: 10.1089/dna.2008.0773
56. Shukla, S. D., Budden, K. F., Neal, R., and Hansbro, P. M. (2017). Microbiome effects on immunity, health and disease in the lung. Clin. Trans. Immunol. 6:e133. doi: 10.1038/cti.2017.6
57. Stempelj, M., Kedinger, M., Augenlicht, L., and Klampfer, L. (2007). Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate. J. Biol. Chem. 282, 9797-9804. doi: 10.1074/jbc. M609426200
58. Stilling, R. M., Van De Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., and Cryan, J. F. (2016). The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis? Neurochem. Int. 99, 110-132. doi: 10.1016/j.neuint.2016.06.011
59. Tamburini, S., and Clemente, J. C. (2017). Gut microbiota: neonatal gut microbiota induces lung immunity against pneumonia. Nat. Rev. Gastroenterol. Hepatol. 14, 263-264. doi: 10.1038/nrgastro.2017.34
60. Thorburn, A. N., Mckenzie, C. I., Shen, S., Stanley, D., Macia, L., Mason, L. J., et al. (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat. Commun. 6:7320. doi: 10.1038/ncomms8320
61. Tremaroli, V., and Backhed, F. (2012). Functional interactions between the gut microbiota and host metabolism. Nature 489, 242-249. doi: 10.1038/nature11552
62. Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., et al. (2014). Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat. Med. 20, 159-166. doi: 10.1038/nm.3444
63. Van de Wiele, T., Van Praet, J. T., Marzorati, M., Drennan, M. B., and Elewaut, D. (2016). How the microbiota shapes rheumatic diseases. Nat. Rev. Rheumatol. 12, 398-411. doi: 10.1038/nrrheum.2016.85
64. Villa, C. R., Ward, W. E., and Comelli, E. M. (2017). Gut microbiota-bone axis. Crit. Rev. Food Sci. Nutr. 57, 1664-1672. doi: 10.1080/10408398.2015.1010034
65. Wang, Y. D., Chen, W. D., Moore, D. D., and Huang, W. (2008a). FXR: a metabolic regulator and cell protector. Cell Res. 18, 1087-1095. doi: 10.1038/cr.2008.289
66. Wang, Y. D., Chen, W. D., Wang, M., Yu, D., Forman, B. M., and Huang, W. (2008b). Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 48, 1632-1643. doi: 10.1002/hep.22519
67. Whisner, C. M., Martin, B. R., Schoterman, M. H., Nakatsu, C. H., Mccabe, L. D., Mccabe, G. P., et al. (2013). Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial. Br. J. Nutr. 110, 1292-1303. doi: 10.1017/S000711451300055X
68. Xie, G., Wang, X., Zhao, A., Yan, J., Chen, W., Jiang, R., et al. (2017). Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes. Sci. Rep. 7:45232. doi: 10.1038/srep45232
69. Xue, L., He, J., Gao, N., Lu, X., Li, M., Wu, X., et al. (2017). Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia. Sci. Rep. 7:45176. doi: 10.1038/srep45176
70. Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., et al. (2016). Gut microbiota induce IGF-1 and promote bone formation and growth. Proc. Natl. Acad. Sci. U.S.A. 113, E7554-E7563. doi: 10.1073/pnas.1607235113
71. Yanaihara, N., Caplen, N., Bowman, E., Seike, M., Kumamoto, K., Yi, M., et al. (2006). Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9, 189-198. doi: 10.1016/j.ccr.2006.01.025
72. Yang, T., Owen, J. L., Lightfoot, Y. L., Kladde, M. P., and Mohamadzadeh, M. (2013). Microbiota impact on the epigenetic regulation of colorectal cancer. Trends Mol. Med. 19, 714-725. doi: 10.1016/j.molmed.2013.08.005
73. Zeng, H., Lazarova, D. L., and Bordonaro, M. (2014). Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention. World J. Gastrointest Oncol. 6, 41-51. doi: 10.4251/wjgo.v6.i2.41
74. Zhang, L., Xie, C., Nichols, R. G., Chan, S. H., Jiang, C., Hao, R., et al. (2016). Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism. mSystems 1:e00070-16. doi: 10.1128/mSystems.00070-16
75. Zhang, Y., Zhou, L., Bao, Y. L., Wu, Y., Yu, C. L., Huang, Y. X., et al. (2010). Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. Chem. Biol. Interact 185, 174-181. doi: 10.1016/j.cbi.2010.03.035
76. Zhao, L., Zhou, X., Cai, W., Shi, R., Yang, G., and Yang, L. (2017). Host intestinal epithelium derived mirnas shape the microbiota and its implication in cardiovascular diseases. J. Am. College Cardiol. 69:1075. doi: 10.1016/S0735-1097(17)34464-9
77. Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., et al. (2016). Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk. Cell 165, 111-124. doi: 10.1016/j.cell.2016.02.011
78. Zhu, Y., Michelle Luo, T., Jobin, C., and Young, H. A. (2011). Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett. 309, 119-127. doi: 10.1016/j.canlet.2011.06.004