Toll-like receptors promote mutually beneficial commensal-host interactions

PLoS Pathogens

Volumn 8, Issue 7, 2012, Pages 1-

  Kubinak, Jason L ^a   Round, June L ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 9; MYD88 PROTEIN, MOUSE;

ARTICLE; B LYMPHOCYTE; BACTEROIDES FRAGILIS; COMMENSALISM; ENTERITIS; FIRMICUTES; IMMUNE SYSTEM; IMMUNOSTIMULATION; INFLAMMATION; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE FLORA; INTESTINE FLUID; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIUM; GENETICS; HUMAN; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; METAGENOME; MICROBIOLOGY; MOUSE; REVIEW; SYMBIOSIS;

ANIMALS; BACTERIA; BACTERIAL PHYSIOLOGICAL PHENOMENA; HUMANS; INFLAMMATION; INTESTINAL MUCOSA; METAGENOME; MICE; MYELOID DIFFERENTIATION FACTOR 88; SYMBIOSIS; TOLL-LIKE RECEPTORS;

EID: 84864598303     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002785     Document Type: Article

References (23)

1. Abreu MT, (2010) Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol 10: 131-144.
2. Lundin A, Bok CM, Aronsson L, Bjorkholm B, Gustafsson JA, et al. (2008) Gut flora, Toll-like receptors and nuclear receptors: a tripartite communication that tunes innate immunity in large intestine. Cell Micro 10: 1093-1103.
3. Lee J, Mo JH, Katakura K, Alkalay I, Rucker AN, et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol 8: 1327-1336.
4. Johansson ME, Ambort D, Pelaseyed T, Schutte A, Gustafsson JK, et al. (2011) Composition and functional role of the mucus layers in the intestine. CMLS 68: 3635-3641.
5. Johansson ME, Larsson JM, Hansson GC, (2011) The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci U S A 108 (Suppl 1): 4659-4665.
6. Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, et al. (2008) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A 105: 15064-15069.
7. Cash HL, Whitham CV, Behrendt CL, Hooper LV, (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313: 1126-1130.
8. Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, et al. (2011) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science 334: 255-258.
9. Vaishnava S, Behrendt CL, Ismail AS, Eckmann L, Hooper LV, (2008) Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A 105: 20858-20863.
10. Fagarasan S, Honjo T, (2003) Intestinal IgA synthesis: regulation of front-line body defences. Nat Rev Immunol 3: 63-72.
11. Macpherson AJ, Gatto D, Sainsbury E, Harriman GR, Hengartner H, et al. (2000) A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288: 2222-2226.
12. Smith K, McCoy KD, Macpherson AJ, (2007) Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin Immunol 19: 59-69.
13. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, et al. (2012) B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity 36: 228-238.
14. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R, (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118: 229-241.
15. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, et al. (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 104: 13780-13785.
16. Strachan DP, (2000) Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax 55 (Suppl 1): S2-S10.
17. Larsson E, Tremaroli V, Lee YS, Koren O, Nookaew I, et al. (2011) Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88. Gut.
18. Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, et al. (2007) Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 117: 3909-3921.
19. Caricilli AM, Picardi PK, de Abreu LL, Ueno M, Prada PO, et al. (2011) Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol 9: e1001212 doi:10.1371/journal.pbio.1001212.
20. Round JL, Lee SM, Li J, Tran G, Jabri B, et al. (2011) The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332: 974-977.
21. Mazmanian SK, Round JL, Kasper DL, (2008) A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 453: 620-625.
22. Round JL, Mazmanian SK, (2010) Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A 107: 12204-12209.
23. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, et al. (2009) Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med 15: 1377-1382.