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Lebeer, S., Vanderleyden, J., De Keersmaecker, S.C., Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol 8 (2010), 171–184 Nice review of probiotic mechanisms of action and how probiotics fit within the microecology of the gut.
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Kant, R., de Vos, W.M., Palva, A., Satokari, R., Immunostimulatory CpG motifs in the genomes of gut bacteria and their role in human health and disease. J Med Microbiol 63 (2014), 293–308 This paper surveys the distribution of microbe-associated molecular patterns, specifically CpG motifs, among commensal bacteria, including probiotic species. Authors make the case that CpG motif-rich DNA, common among probiotic species, may drive the immune stimulatory effects observed in many probiotic strains.
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von Schillde, M.A., Hormannsperger, G., Weiher, M., Alpert, C.A., Hahne, H., Bauerl, C., van Huynegem, K., Steidler, L., Hrncir, T., Perez-Martinez, G., et al. Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines. Cell Host Microbe 11 (2012), 387–396 This paper is a nice demonstration through knockout mutants of a gene associated with a specific probiotic function in vivo. Anti-inflammatory activity was found to be associated with the production of the protease lactocepin made by Lactobacillus paracasei in a mouse model, and a strain deficient in the gene encoding this protease lost its anti-inflammatory ability.
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