Inflammatory bowel disease and pancreatitis: A review

Journal of Crohn's and Colitis

Volumn 10, Issue 1, 2016, Pages 95-104

  Ramos, Lídia Roque ^a   Sachar, David B ^a   DiMaio, Christopher J ^a   Colombel, Jean Frédéric ^a   Torres, Joana ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

acute pancreatitis; autoimmune pancreatitis; chronic pancreatitis; Crohn's disease; exocrine insufficiency; hyperamylasaemia; hyperlipasaemia; Inflammatory bowel disease; ulcerative colitis

Indexed keywords

6 MERCAPTOPURINE DERIVATIVE; ALCOHOL; AZATHIOPRINE; CORTICOSTEROID; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; STEROID;

ACUTE PANCREATITIS; ALCOHOL CONSUMPTION; AUTOIMMUNE PANCREATITIS; CHOLELITHIASIS; CHRONIC PANCREATITIS; CLINICAL FEATURE; CORTICOSTEROID THERAPY; CROHN DISEASE; DISEASE ASSOCIATION; ENDOSCOPIC ECHOGRAPHY; EXOCRINE SECRETION; FOLLOW UP; GALLSTONE; HUMAN; HYPERAMYLASEMIA; INFLAMMATORY BOWEL DISEASE; LABORATORY TEST; MEDICINE; MEDLINE; PANCREAS DISEASE; PANCREAS DUCT; PANCREAS EXOCRINE INSUFFICIENCY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STEROID THERAPY; SYSTEMATIC REVIEW; TREATMENT INDICATION; ULCERATIVE COLITIS; ACUTE DISEASE; ADULT; AGE DISTRIBUTION; CHRONIC DISEASE; COMORBIDITY; FEMALE; IMMUNOLOGY; INCIDENCE; INFLAMMATORY BOWEL DISEASES; MALE; MIDDLE AGED; PANCREATITIS; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX RATIO; YOUNG ADULT;

ACUTE DISEASE; ADULT; AGE DISTRIBUTION; CHRONIC DISEASE; COMORBIDITY; FEMALE; HUMANS; INCIDENCE; INFLAMMATORY BOWEL DISEASES; MALE; MIDDLE AGED; PANCREATITIS; PROGNOSIS; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION; YOUNG ADULT;

EID: 84963727929     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1093/ecco-jcc/jjv153     Document Type: Review

References (91)

1. Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007;448:427-34
2. Ott C, Schölmerich J. Extraintestinal manifestations and complications in IBD. Nat Rev Gastroenterol Hepatol 2013;10:585-95
3. Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 2013;144:1252-61
4. Ueki T, Kawamoto K, Otsuka Y, et al. Prevalence and clinicopathological features of autoimmune pancreatitis in Japanese patients with inflammatory bowel disease. Pancreas 2015;44:434-40
5. Navaneethan U, Shen B. Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease. Inflamm Bowel Dis 2010;16:1598-619
6. Pitchumoni CS, Rubin A, Das K. Pancreatitis in inflammatory bowel diseases. J Clin Gastroenterol 2010;44:246-53
7. Jasdanwala S, Babyatsky M. Crohn's disease and acute pancreatitis. A review of literature. J Pancreas 2015;16:136-42
8. Bradley EL 3rd. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg 1993;128:586-90
9. Braganza JM, Lee SH, McCloy RF, McMahon MJ. Chronic pancreatitis. Lancet 2011;377:1184-97
10. Yadav D, Whitcomb DC. The role of alcohol and smoking in pancreatitis. Nat Rev Gastroenterol Hepatol 2010;7:131-45
11. Hamada S, Masamune A, Kikuta K, Hirota M, Tsuji I, Simosegawa T. Nationwide epidemiological survey of autoimmune pancreatitis in Japan. Pancreas 2014;43:1244-8
12. Shen HN, Lu CL, Li CY. Epidemiology of first-attack acute pancreatitis in Taiwan from 2000 through 2009. Pancreas 2012;41:696-702
13. Bermejo F, Lopez-Sanroman A, Taxonera C, et al. Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprineinduced pancreatitis. Aliment Pharmacol Ther 2008;28:623-8
14. Weber P, Seibold F, Jenss H. Acute pancreatitis in Crohn's disease. J Clin Gastroenterol 1993;17:286-91
15. Rasmussen HH, Fonager K, Sørensen HT, Pedersen L, Dahlerup JF, Steffensen FH. Risk of acute pancreatitis in patients with chronic inflammatory bowel disease. A Danish 16-year nationwide follow-up study. Scand J Gastroenterol 1999;34:199-201
16. Moolsintong P, Loftus EV Jr, Chari ST, Egan LJ, Tremaine WJ, Sandborn WJ. Acute pancreatitis in patients with Crohn's disease: clinical features and outcomes. Inflamm Bowel Dis 2005;11:1080-4
17. Inoue H, Shiraki K, Okano H, et al. Acute pancreatitis in patients with ulcerative colitis. Dig Dis Sci 2005;50:1064-7
18. Aktas H, De Ridder L, Haringsma J, Kuipers EJ, Mensink PBF. Complications of single-balloon enteroscopy: a prospective evaluation of 166 procedures. Endoscopy 2010;42:365-8
19. Matsushita M, Nagasawa M, Sato Y, Souda KI, Kobayashi Y. Primary sclerosing cholangitis associated with limy bile and acute pancreatitis. Pancreatology 2005;5:466-9
20. Gschwantler M, Kogelbauer G, Klose W, Bibus B, Tscholakoff D, Weiss W. The pancreas as a site of granulomatous inflammation in Crohn's disease. Gastroenterology 1995;108:1246-9
21. Rivas JM, Erim T, Berho ME, Petras RE, Castro FJ. Crohn's disease of the common bile duct and ampulla causing obstructive jaundice and acute pancreatitis. Am J Gastroenterol 2009;104:1053-5
22. Heaton KW, Read AE. Gallstones in patients with disorders of the terminal ileum and disturbed bile salt metabolism. Br Med J 1969;3:494-6
23. Bargiggia S, Maconi G, Elli M, et al. Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single center. J Clin Gastroenterol 2003;36:417-20
24. Kratzer W, Haenle MM, Mason RA, von Tirpitz C, Kaechele V. Prevalence of cholelithiasis in patients with chronic inflammatory bowel disease. World J Gastroenterol 2005;11:6170-5
25. Parente F, Pastore L, Bargiggia S, et al. Incidence and risk factors for gallstones in patients with inflammatory bowel disease: a large case-control study. Hepatology 2007;45:1267-74
26. Gizard E, Ford AC, Bronowicki JP, Peyrin-Biroulet L. Systematic review: the epidemiology of the hepatobiliary manifestations in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2014;40:3-15
27. Wang DQ, Afdhal NH. Gallstone disease. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th edn. Philadelphia: Elsevier Saunders; 2016: 1100-33
28. Lapidus A, Åkerlund JE, Einarsson C. Gallbladder bile composition in patients with Crohn's disease. World J Gastroenterol 2006;12:70-4
29. Nitsche C, Maertin S, Scheiber J, Ritter CA, Lerch MM, Mayerle J. Druginduced pancreatitis. Curr Gastroenterol Rep 2012;14:131-8
30. Nitsche CJ, Jamieson N, Lerch MM, Mayerle JV. Drug induced pancreatitis. Best Pract Res Clin Gastroenterol 2010;24:143-55
31. van Geenen EJ, de Boer NK, Stassen P, et al. Azathioprine or mercaptopurine-induced acute pancreatitis is not a disease-specific phenomenon. Aliment Pharmacol Ther 2010;31:1322-9
32. Chaparro M, Ordás I, Cabré E, et al. Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients. Inflamm Bowel Dis 2013;19:1404-10
33. Weersma RK, Peters FT, Oostenbrug LE, et al. Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases. Aliment Pharmacol Ther 2004;20:843-50
34. Liu YP, Wu HY, Yang X, et al. Association between thiopurine S-methyltransferase polymorphisms and thiopurine-induced adverse drug reactions in patients with inflammatory bowel disease: a meta-analysis. PLoS One 2015. doi: 10.1371/journal.pone.0121745
35. Heap GA, Weedon MN, Bewshea CM, et al. HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nat Genet 2014;46:1131-4
36. Ledder OD, Lemberg DA, Ooi CY, Day AS. Are thiopurines always contraindicated after thiopurine-induced pancreatitis in inflammatory bowel disease? J Pediatr Gastroenterol Nutr 2013;57:583-6
37. Hindorf U, Johansson M, Eriksson A, Kvifors E, Almer SH. Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2009;29:654-61
38. Beswick L, Hair CS, Dowling D. Letter: Successful mercaptopurine therapy after azathioprine-related pancreatitis in patients with IBD. Aliment Pharmacol Ther 2013;37:162
39. De Boer NK, Reinisch W, Teml A, et al. 6-thioguanine treatment in inflammatory bowel disease: a critical appraisal by a European 6-TG working party. Digestion 2006;73:25-31
40. Musumba CO. Review article: the association between nodular regenerative hyperplasia, inflammatory bowel disease and thiopurine therapy. Aliment Pharmacol Ther 2013;38:1025-37
41. Arai Y, Arihiro S, Ide D, et al. Acute pancreatitis due to pH-dependent mesalazine that occurred in the course of ulcerative colitis. Case Rep Gastroenterol 2011;5:610-6
42. Kim KH, Kim TN, Jang BI. A case of acute pancreatitis caused by 5-aminosalicylic acid suppositories in a patient with ulcerative colitis. Korean J Gastroenterol 2007; 50:379-83
43. Paerregaard A, Krasilnikoff PA. Pancreatitis in a child after rectal administration of 5-aminosalicylic acid. Inflamm Bowel Dis 1997;3:20-1
44. Munk EM, Pedersen L, Floyd A, Nørgård B, Rasmussen HH, Sørensen HT. Inflammatory bowel diseases, 5-aminosalicylic acid and sulfasalazine treatment and risk of acute pancreatitis: a population-based case-control study. Am J Gastroenterol 2004;99:884-8
45. Swanson GR, Sedghi S, Farhadi A, Keshavarzian A. Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease. Alcohol 2010;44:223-8
46. Tenner S, Baillie J, DeWitt J, Vege SS. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol 2013;108:1400-15
47. Lankisch PG, Apte M, Banks PA. Acute pancreatitis. Lancet 2015;386:85-96
48. Bokemeyer B. Asymptomatic elevation of serum lipase and amylase in conjunction with Crohn's disease and ulcerative colitis. Z Gastroenterol 2002;40:5-10
49. Wu BU, Banks PA. Clinical management of patients with acute pancreatitis. Gastroenterology 2013;144:1272-81
50. Triantafillidis JK, Cheracakis P, Hereti IA, Argyros N, Karra E. Acute idiopathic pancreatitis complicating active Crohn's disease: favorable response to infliximab treatment. Am J Gastroenterol 2000;95:3334-6
51. Conwell DL, Lee LS, Yadav D, et al. American Pancreatic Association practice guidelines in chronic pancreatitis: evidence-based report on diagnostic guidelines. Pancreas 2014;43:1143-62
52. Barthet M, Hastier P, Bernard JP, et al. Chronic pancreatitis and inflammatory bowel disease: true or coincidental association? Am J Gastroenterol 1999;94:2141-8
53. Axon AT, Ashton MG, Lintott DJ. Chronic pancreatitis and inflammatory bowel disease. Clin Radiol 1979;30:179-82
54. Gómez EG, San Román AL, San José FB. Idiopathic pancreatitis in inflammatory bowel disease. J Crohn's Colitis 2008;2:237-40
55. Knafelz D, Panetta F, Monti L, et al. Chronic pancreatitis as presentation of Crohn's disease in a child. World J Gastroenterol 2013;19:5204-6
56. Grandval P, Barthet M, Desjeux A, et al. Pseudotumorous chronic pancreatitis associated with inflammatory bowel disease. Dig Dis Sci 2001;46:898-900
57. Bhatt SP, Makharia GK. An unusual association between chronic pancreatitis and ulcerative colitis. J Pancreas 2008;9:74-75
58. Ravi K, Chari ST, Vege SS, Sandborn WJ, Smyrk TC, Loftus EV Jr. Inflammatory bowel disease in the setting of autoimmune pancreatitis. Inflamm Bowel Dis 2009;15:1326-30
59. Veloso FT, Dias LM, Carvalho J, Fraga J, Saleiro J. Ulcerative colitis, primary biliary cirrhosis, and chronic pancreatitis: coincident or coexistent? J Clin Gastroenterol 1993;16:55-7
60. Said K, Albiin N, Lindberg B, et al. Pancreatic duct changes are not associated with early signs of chronic pancreatitis at magnetic resonance imaging (MRI) in patients with primary sclerosing cholangitis. Scand J Gastroenterol 2010;45:980-6
61. Özkavukcu E, Erden A, Erden I. Pancreatic changes in patients with primary sclerosing cholangitis: MR cholangiopancreatography and MRI findings. Eur J Radiol 2009;70:118-21
62. Kamisawa T, Chari ST, Giday SA, et al. Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey. Pancreas 2011;40:809-14
63. Shimosegawa T, Chari ST, Frulloni L, et al. International Consensus Diagnostic Criteria for Autoimmune Pancreatitis: guidelines of the International Association of Pancreatology. Pancreas 2011;40:352-8
64. Kamisawa T, Chari ST, Lerch MM, Kim M, Gress TM, Shimosegawa T. Recent advances in autoimmune pancreatitis: type 1 and type 2. Gut 2013;62:1373-80
65. Hart PA, Zen Y, Chari ST. Recent advances in autoimmune pancreatitis. Gastroenterology 2015;149:39-51
66. Maruyama M, Watanabe T, Kanai K, et al. International consensus diagnostic criteria for autoimmune pancreatitis and its Japanese amendment have improved diagnostic ability over existing criteria. Gastroenterol Res Pract 2013. DOI:10.1155/2013/456965
67. Kawa S, Okazaki K, Notohara K, Watanabe M, Shimosegawa T. Autoimmune pancreatitis complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis. J Gastroenterol 2014;50:805-15
68. Maire F, Rebours V, Vullierme MP, et al. Does tobacco influence the natural history of autoimmune pancreatitis? Pancreatology 2014;14:284-8
69. Detlefsen S, Zamboni G, Frulloni L, et al. Clinical features and relapse rates after surgery in type 1 autoimmune pancreatitis differ from type 2: a study of 114 surgically treated European patients. Pancreatology 2012;12:276-83
70. Song TJ, Kim JH, Kim MH, et al. Comparison of clinical findings between histologically confirmed type 1 and type 2 autoimmune pancreatitis. J Gastroenterol Hepatol 2012;27:700-8
71. Kamisawa T, Kim MH, Liao WC, et al. Clinical characteristics of 327 Asian patients with autoimmune pancreatitis based on Asian diagnostic criteria. Pancreas 2011;40:200-5
72. Maire F, Le Baleur Y, Rebours V, et al. Outcome of patients with type 1 or 2 autoimmune pancreatitis. Am J Gastroenterol 2011;106:151-6
73. Park SH, Kim D, Ye BD, et al. The characteristics of ulcerative colitis associated with autoimmune pancreatitis. J Clin Gastroenterol 2013;47:520-5
74. Chapin LE, Scudamore HH, Baggenstoss AH, Bargen JA. Regional enteritis: associated visceral changes. Gastroenterology 1956;30:404-15
75. Ball WP, Baggenstoss AH, Bargen JA. Pancreatic lesions associated with chronic ulcerative colitis. Arch Pathol 1950;50:347-58
76. Toda N, Akahane M, Kiryu S, et al. Pancreas duct abnormalities in patients with ulcerative colitis: a magnetic resonance pancreatography study. Inflamm Bowel Dis 2005;11:903-8
77. Heikius B, Niemelä S, Lehtola J, Karttunen T, Lähde S. Pancreatic duct abnormalities and pancreatic function in patients with chronic inflammatory bowel disease. Scand J Gastroenterol 1996;31:517-23
78. Maconi G, Dominici R, Molteni M, et al. Prevalence of pancreatic insufficiency in inflammatory bowel diseases. Assessment by fecal elastase-1. Dig Dis Sci 2008;53:262-70
79. Heikius B, Niemelä S, Lehtola J, Karttunen TJ. Elevated pancreatic enzymes in inflammatory bowel disease are associated with extensive disease. Am J Gastroenterol 1999;94:1062-9
80. Katz S, Bank S, Greenberg RE, Lendvai S, Lesser M, Napolitano B. Hyperamylasemia in inflammatory bowel disease. J Clin Gastroenterol 1988;10:627-30
81. Pieper-Bigelow C, Strocchi A, Levitt MD. Where does serum amylase come from and where does it go? Gastroenterol Clin North Am 1990;19:793-810
82. Hameed AM, Lam VW, Pleass HC. Significant elevations of serum lipase not caused by pancreatitis: a systematic review. HPB (Oxford) 2014;17:99-112
83. Stöcker W, Otte M, Ulrich S, et al. Autoimmunity to pancreatic juice in Crohn's disease. Results of an autoantibody screening in patients with chronic inflammatory bowel disease. Scand J Gastroenterol Suppl 1987;139:41-52
84. Komorowski L, Teegen B, Probst C, et al. Autoantibodies against exocrine pancreas in Crohn's disease are directed against two antigens: the glycoproteins CUZD1 and GP2. J Crohn's Colitis 2013;7:780-90
85. Barthet M, Lesavre N, Desplats S, et al. Frequency and characteristics of pancreatitis in patients with inflammatory bowel disease. Pancreatology 2006;6:464-71
86. Seibold F, Scheurlen M, Müller A, Jenss H, Weber P. Impaired pancreatic function in patients with Crohn's disease with and without pancreatic autoantibodies. J Clin Gastroenterol 1996;22:202-6
87. Lakatos PL, Aitorjay I, Szamosi T, et al. Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease, and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a Hungarian IBD cohort. Inflamm Bowel Dis 2009;15:365-74
88. Schoepfer AM, Schaffer T, Mueller S, et al. Phenotypic associations of Crohn's disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss cohort. Inflamm Bowel Dis 2009;15:1358-67
89. Desplat-Jégo S, Johanet C, Escande A, et al. Update in anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: results of a multicenter study. World J Gastroenterol 2007;13:2312-8
90. Joossens S, Vermeire S, Van Steen K, et al. Pancreatic autoantibodies in inflammatory bowel disease. Inflamm Bowel Dis 2004;10:771-7
91. Papp M1, Sipeki N2, Tornai T2, et al. Rediscovery of the antipancreatic antibodies and evaluation of their prognostic value in a prospective clinical cohort of Crohn's patients: the importance of specific target antigens (GP2 and CUZD1). J Crohns Colitis 2015;9:659-68