Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways

Cell

Volumn 170, Issue 1, 2017, Pages 185-198.e16

  Bellono, Nicholas W ^a   Bayrer, James R ^b   Leitch, Duncan B ^a   Castro, Joel ^c,d   Zhang, Chuchu ^a   O'Donnell, Tracey A ^c,d   Brierley, Stuart M ^c,d   Ingraham, Holly A ^b   Julius, David ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c FLINDERS UNIVERSITY   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

chemosensation; enterochromaffin cell; gastrointestinal physiology; inflammatory bowel disease; intestinal organoid; microbial metabolites; neurogastroenterology; nociception; sensory transduction; visceral pain

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CATECHOLAMINE; CHEMOSENSORY RECEPTOR; EPINEPHRINE; NORADRENALIN; RECEPTOR; SEROTONIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; CALCIUM CHANNEL; NERVE PROTEIN; OLFACTORY RECEPTOR; OLFR558 PROTEIN, MOUSE; SEROTONIN 3 RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRPA1 PROTEIN, HUMAN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL COMMUNICATION; CELL FUNCTION; CELL STIMULATION; CELL STRUCTURE; CONTROLLED STUDY; ENTEROCHROMAFFIN CELL; HEK293 CELL LINE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; INTESTINE FUNCTION; INTESTINE INNERVATION; MALE; MOUSE; MUSCLE SPINDLE AFFERENT NERVE; NERVE EXCITABILITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY RECEPTOR; PELVIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; SYNAPSE; AMINO ACID SEQUENCE; ANIMAL; CHEMORECEPTOR CELL; CYTOLOGY; GASTROINTESTINAL TRACT; GENE EXPRESSION PROFILING; IRRITABLE COLON; METABOLISM; NERVE FIBER; NERVE TRACT; PATHOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CALCIUM CHANNELS; CATECHOLAMINES; CHEMORECEPTOR CELLS; ENTEROCHROMAFFIN CELLS; GASTROINTESTINAL TRACT; GENE EXPRESSION PROFILING; HUMANS; IRRITABLE BOWEL SYNDROME; MICE; NERVE FIBERS; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; RECEPTORS, ODORANT; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SIGNAL TRANSDUCTION; SYNAPSES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 85021163248     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.05.034     Document Type: Article

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