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Volumn 14, Issue 3, 2018, Pages 133-150

Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GADOLINIUM; MULTIDRUG RESISTANCE PROTEIN 1;

EID: 85042640362     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2017.188     Document Type: Review
Times cited : (1909)

References (256)
  • 1
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic, B. V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201 (2008).
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 2
    • 85021150580 scopus 로고    scopus 로고
    • Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease
    • Kisler, K., Nelson, A. R., Montagne, A. & Zlokovic, B. V. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat. Rev. Neurosci. 18, 419-434 (2017).
    • (2017) Nat. Rev. Neurosci. , vol.18 , pp. 419-434
    • Kisler, K.1    Nelson, A.R.2    Montagne, A.3    Zlokovic, B.V.4
  • 3
    • 84888019151 scopus 로고    scopus 로고
    • The pathobiology of vascular dementia
    • Iadecola, C. The pathobiology of vascular dementia. Neuron 80, 844-866 (2013).
    • (2013) Neuron , vol.80 , pp. 844-866
    • Iadecola, C.1
  • 4
    • 84929138470 scopus 로고    scopus 로고
    • Targeted delivery of protein and gene medicines through the blood-brain barrier
    • Pardridge, W. M. Targeted delivery of protein and gene medicines through the blood-brain barrier. Clin. Pharmacol. Ther. 97, 347-361 (2015).
    • (2015) Clin. Pharmacol. Ther. , vol.97 , pp. 347-361
    • Pardridge, W.M.1
  • 5
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic, B. V. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci. 12, 723-738 (2011).
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 6
    • 84947901598 scopus 로고    scopus 로고
    • Establishment and dysfunction of the blood-brain barrier
    • Zhao, Z., Nelson, A. R., Betsholtz, C. & Zlokovic, B. V. Establishment and dysfunction of the blood-brain barrier. Cell 163, 1064-1078 (2015).
    • (2015) Cell , vol.163 , pp. 1064-1078
    • Zhao, Z.1    Nelson, A.R.2    Betsholtz, C.3    Zlokovic, B.V.4
  • 7
    • 85014656015 scopus 로고    scopus 로고
    • Pericytes of the neurovascular unit: Key functions and signaling pathways
    • Sweeney, M. D., Ayyadurai, S. & Zlokovic, B. V. Pericytes of the neurovascular unit: key functions and signaling pathways. Nat. Neurosci. 19, 771-783 (2016).
    • (2016) Nat. Neurosci. , vol.19 , pp. 771-783
    • Sweeney, M.D.1    Ayyadurai, S.2    Zlokovic, B.V.3
  • 8
    • 0022371325 scopus 로고
    • Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: Kinetics of unidirectional influx, carrier specificity and effects of glucagon
    • Mann, G. E., Zlokovic, B. V. & Yudilevich, D. L. Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochim. Biophys. Acta 819, 241-248 (1985).
    • (1985) Biochim. Biophys. Acta , vol.819 , pp. 241-248
    • Mann, G.E.1    Zlokovic, B.V.2    Yudilevich, D.L.3
  • 9
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola, C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat. Rev. Neurosci. 5, 347-360 (2004).
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 347-360
    • Iadecola, C.1
  • 10
    • 84898017077 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis
    • Friese, M. A., Schattling, B. & Fugger, L. Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis. Nat. Rev. Neurol. 10, 225-238 (2014).
    • (2014) Nat. Rev. Neurol. , vol.10 , pp. 225-238
    • Friese, M.A.1    Schattling, B.2    Fugger, L.3
  • 11
    • 85033373065 scopus 로고    scopus 로고
    • Alzheimer's disease: A matter of blood-brain barrier dysfunction?
    • Montagne, A., Zhao, Z. & Zlokovic, B. Alzheimer's disease: a matter of blood-brain barrier dysfunction? J. Exp. Med. 214, 3151-3169 (2017).
    • (2017) J. Exp. Med. , vol.214 , pp. 3151-3169
    • Montagne, A.1    Zhao, Z.2    Zlokovic, B.3
  • 12
    • 84923265935 scopus 로고    scopus 로고
    • Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue
    • Sakadžic, S. et al. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat. Commun. 5, 5734 (2014).
    • (2014) Nat. Commun. , vol.5 , pp. 5734
    • Sakadžic, S.1
  • 13
    • 85010928380 scopus 로고    scopus 로고
    • Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
    • Kisler, K. et al. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat. Neurosci. 20, 406-416 (2017).
    • (2017) Nat. Neurosci. , vol.20 , pp. 406-416
    • Kisler, K.1
  • 14
    • 84901260638 scopus 로고    scopus 로고
    • Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid
    • Nguyen, L. N. et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature 509, 503-506 (2014).
    • (2014) Nature , vol.509 , pp. 503-506
    • Nguyen, L.N.1
  • 15
    • 84901269974 scopus 로고    scopus 로고
    • Mfsd2a is critical for the formation and function of the blood-brain barrier
    • Ben-Zvi, A. et al. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature 509, 507-511 (2014).
    • (2014) Nature , vol.509 , pp. 507-511
    • Ben-Zvi, A.1
  • 16
    • 84901913570 scopus 로고    scopus 로고
    • Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid
    • Mokgokong, R., Wang, S., Taylor, C. J., Barrand, M. A. & Hladky, S. B. Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid. Pflugers Arch. 466, 887-901 (2014).
    • (2014) Pflugers Arch. , vol.466 , pp. 887-901
    • Mokgokong, R.1    Wang, S.2    Taylor, C.J.3    Barrand, M.A.4    Hladky, S.B.5
  • 18
    • 84978708663 scopus 로고    scopus 로고
    • Glutamate-mediated blood-brain barrier opening: Implications for neuroprotection and drug delivery
    • Vazana, U. et al. Glutamate-mediated blood-brain barrier opening: implications for neuroprotection and drug delivery. J. Neurosci. 36, 7727-7739 (2016).
    • (2016) J. Neurosci. , vol.36 , pp. 7727-7739
    • Vazana, U.1
  • 19
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • Shibata, M. et al. Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106, 1489-1499 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 1489-1499
    • Shibata, M.1
  • 20
    • 4043061467 scopus 로고    scopus 로고
    • LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms
    • Deane, R. et al. LRP/amyloid β-peptide interaction mediates differential brain efflux of Aβ isoforms. Neuron 43, 333-344 (2004).
    • (2004) Neuron , vol.43 , pp. 333-344
    • Deane, R.1
  • 21
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins e and J in the mouse central nervous system
    • Bell, R. D. et al. Transport pathways for clearance of human Alzheimer's amyloid β-peptide and apolipoproteins E and J in the mouse central nervous system. J. Cereb. Blood Flow Metab. 27, 909-918 (2007).
    • (2007) J. Cereb. Blood Flow Metab. , vol.27 , pp. 909-918
    • Bell, R.D.1
  • 22
    • 57449084208 scopus 로고    scopus 로고
    • ApoE isoform-specific disruption of amyloid β peptide clearance from mouse brain
    • Deane, R. et al. apoE isoform-specific disruption of amyloid β peptide clearance from mouse brain. J. Clin. Invest. 118, 4002-4013 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 4002-4013
    • Deane, R.1
  • 23
    • 78650011841 scopus 로고    scopus 로고
    • Neurodegeneration and the neurovascular unit
    • Zlokovic, B. V. Neurodegeneration and the neurovascular unit. Nat. Med. 16, 1370-1371 (2010).
    • (2010) Nat. Med. , vol.16 , pp. 1370-1371
    • Zlokovic, B.V.1
  • 24
    • 84956617728 scopus 로고    scopus 로고
    • Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier
    • Storck, S. E. et al. Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier. J. Clin. Invest. 126, 123-136 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 123-136
    • Storck, S.E.1
  • 25
    • 84933277693 scopus 로고    scopus 로고
    • Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
    • Zhao, Z. et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat. Neurosci. 18, 978-987 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 978-987
    • Zhao, Z.1
  • 26
    • 84958114093 scopus 로고    scopus 로고
    • Interaction between cerebrovascular disease and Alzheimer pathology
    • Saito, S. & Ihara, M. Interaction between cerebrovascular disease and Alzheimer pathology. Curr. Opin. Psychiatry 29, 168-173 (2016).
    • (2016) Curr. Opin. Psychiatry , vol.29 , pp. 168-173
    • Saito, S.1    Ihara, M.2
  • 27
    • 85042671544 scopus 로고    scopus 로고
    • Clearance systems in the brain- implications for Alzheimer disease
    • Tarasoff-Conway, J. M. et al. Clearance systems in the brain- implications for Alzheimer disease. Nat. Rev. Neurol. 12, 248 (2016).
    • (2016) Nat. Rev. Neurol. , vol.12 , pp. 248
    • Tarasoff-Conway, J.M.1
  • 28
    • 84961216596 scopus 로고    scopus 로고
    • Lymphatic clearance of the brain: Perivascular, paravascular and significance for neurodegenerative diseases
    • Bakker, E. N. et al. Lymphatic clearance of the brain: perivascular, paravascular and significance for neurodegenerative diseases. Cell. Mol. Neurobiol. 36, 181-194 (2016).
    • (2016) Cell. Mol. Neurobiol. , vol.36 , pp. 181-194
    • Bakker, E.N.1
  • 29
    • 0000517316 scopus 로고
    • Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit
    • Bradbury, M. W., Cserr, H. F. & Westrop, R. J. Drainage of cerebral interstitial fluid into deep cervical lymph of the rabbit. Am. J. Physiol. 240, F329-F336 (1981).
    • (1981) Am. J. Physiol. , vol.240 , pp. F329-F336
    • Bradbury, M.W.1    Cserr, H.F.2    Westrop, R.J.3
  • 30
    • 0025729615 scopus 로고
    • Distribution of extracellular tracers in perivascular spaces of the rat brain
    • Ichimura, T., Fraser, P. A. & Cserr, H. F. Distribution of extracellular tracers in perivascular spaces of the rat brain. Brain Res. 545, 103-113 (1991).
    • (1991) Brain Res. , vol.545 , pp. 103-113
    • Ichimura, T.1    Fraser, P.A.2    Cserr, H.F.3
  • 31
    • 84942469639 scopus 로고    scopus 로고
    • A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
    • Aspelund, A. et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J. Exp. Med. 212, 991-999 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 991-999
    • Aspelund, A.1
  • 32
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • Louveau, A. et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337-341 (2015).
    • (2015) Nature , vol.523 , pp. 337-341
    • Louveau, A.1
  • 33
    • 84982121622 scopus 로고    scopus 로고
    • Vascular, glial, and lymphatic immune gateways of the central nervous system
    • Engelhardt, B. et al. Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta Neuropathol. 132, 317-338 (2016).
    • (2016) Acta Neuropathol. , vol.132 , pp. 317-338
    • Engelhardt, B.1
  • 34
    • 85009754057 scopus 로고    scopus 로고
    • The movers and shapers in immune privilege of the CNS
    • Engelhardt, B., Vajkoczy, P. & Weller, R. O. The movers and shapers in immune privilege of the CNS. Nat. Immunol. 18, 123-131 (2017).
    • (2017) Nat. Immunol. , vol.18 , pp. 123-131
    • Engelhardt, B.1    Vajkoczy, P.2    Weller, R.O.3
  • 35
    • 84885775321 scopus 로고    scopus 로고
    • Sleep drives metabolite clearance from the adult brain
    • Xie, L. et al. Sleep drives metabolite clearance from the adult brain. Science 342, 373-377 (2013).
    • (2013) Science , vol.342 , pp. 373-377
    • Xie, L.1
  • 36
    • 0021959647 scopus 로고
    • Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space
    • Rennels, M. L., Gregory, T. F., Blaumanis, O. R., Fujimoto, K. & Grady, P. A. Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space. Brain Res. 326, 47-63 (1985).
    • (1985) Brain Res. , vol.326 , pp. 47-63
    • Rennels, M.L.1    Gregory, T.F.2    Blaumanis, O.R.3    Fujimoto, K.4    Grady, P.A.5
  • 37
    • 84865123660 scopus 로고    scopus 로고
    • A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
    • Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl Med. 4, 147ra111 (2012).
    • (2012) Sci. Transl Med. , vol.4 , pp. 147ra111
    • Iliff, J.J.1
  • 39
    • 85029231897 scopus 로고    scopus 로고
    • Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma
    • Smith, A. J., Yao, X., Dix, J. A., Jin, B.-J. & Verkman, A. S. Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma. eLife 6, e27679 (2017).
    • (2017) ELife , vol.6 , pp. e27679
    • Smith, A.J.1    Yao, X.2    Dix, J.A.3    Jin, B.-J.4    Verkman, A.S.5
  • 40
    • 85029502411 scopus 로고    scopus 로고
    • Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
    • Holter, K. E. et al. Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow. Proc. Natl Acad. Sci. USA 114, 9894-9899 (2017).
    • (2017) Proc. Natl Acad. Sci. USA , vol.114 , pp. 9894-9899
    • Holter, K.E.1
  • 41
    • 84924273728 scopus 로고    scopus 로고
    • Mechanisms of fluid movement into, through and out of the brain: Evaluation of the evidence
    • Hladky, S. B. & Barrand, M. A. Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence. Fluids Barriers CNS 11, 26 (2014).
    • (2014) Fluids Barriers CNS , vol.11 , pp. 26
    • Hladky, S.B.1    Barrand, M.A.2
  • 42
    • 84939536467 scopus 로고    scopus 로고
    • A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans
    • Spector, R., Robert Snodgrass, S. & Johanson, C. E. A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans. Exp. Neurol. 273, 57-68 (2015).
    • (2015) Exp. Neurol. , vol.273 , pp. 57-68
    • Spector, R.1    Robert Snodgrass, S.2    Johanson, C.E.3
  • 44
    • 85002525199 scopus 로고    scopus 로고
    • Glymphatic solute transport does not require bulk flow
    • Asgari, M., de Zélicourt, D. & Kurtcuoglu, V. Glymphatic solute transport does not require bulk flow. Sci. Rep. 6, 38635 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 38635
    • Asgari, M.1    De Zélicourt, D.2    Kurtcuoglu, V.3
  • 45
    • 85008490303 scopus 로고    scopus 로고
    • Spatial model of convective solute transport in brain extracellular space does not support a 'glymphatic' mechanism
    • Jin, B.-J., Smith, A. J. & Verkman, A. S. Spatial model of convective solute transport in brain extracellular space does not support a 'glymphatic' mechanism. J. Gen. Physiol. 148, 489-501 (2016).
    • (2016) J. Gen. Physiol. , vol.148 , pp. 489-501
    • Jin, B.-J.1    Smith, A.J.2    Verkman, A.S.3
  • 46
    • 84962173232 scopus 로고    scopus 로고
    • Brain imaging of neurovascular dysfunction in Alzheimer's disease
    • Montagne, A. et al. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 131, 687-707 (2016).
    • (2016) Acta Neuropathol. , vol.131 , pp. 687-707
    • Montagne, A.1
  • 47
    • 84953228317 scopus 로고    scopus 로고
    • Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
    • Nelson, A. R., Sweeney, M. D., Sagare, A. P. & Zlokovic, B. V. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim. Biophys. Acta 1862, 887-900 (2016).
    • (2016) Biochim. Biophys. Acta , vol.1862 , pp. 887-900
    • Nelson, A.R.1    Sweeney, M.D.2    Sagare, A.P.3    Zlokovic, B.V.4
  • 48
    • 84975882747 scopus 로고    scopus 로고
    • Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis
    • Iturria-Medina, Y. et al. Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. Nat. Commun. 7, 11934 (2016).
    • (2016) Nat. Commun. , vol.7 , pp. 11934
    • Iturria-Medina, Y.1
  • 49
    • 84921326695 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown in the aging human hippocampus
    • Montagne, A. et al. Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302 (2015).
    • (2015) Neuron , vol.85 , pp. 296-302
    • Montagne, A.1
  • 50
    • 84934444613 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
    • Sweeney, M. D., Sagare, A. P. & Zlokovic, B. V. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J. Cereb. Blood Flow Metab. 35, 1055-1068 (2015).
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 1055-1068
    • Sweeney, M.D.1    Sagare, A.P.2    Zlokovic, B.V.3
  • 51
    • 84992206113 scopus 로고    scopus 로고
    • Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: A cross-sectional study
    • Arvanitakis, Z., Capuano, A. W., Leurgans, S. E., Bennett, D. A. & Schneider, J. A. Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study. Lancet Neurol. 15, 934-943 (2016).
    • (2016) Lancet Neurol. , vol.15 , pp. 934-943
    • Arvanitakis, Z.1    Capuano, A.W.2    Leurgans, S.E.3    Bennett, D.A.4    Schneider, J.A.5
  • 52
    • 84883402644 scopus 로고    scopus 로고
    • Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre
    • Toledo, J. B. et al. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre. Brain J. Neurol. 136, 2697-2706 (2013).
    • (2013) Brain J. Neurol. , vol.136 , pp. 2697-2706
    • Toledo, J.B.1
  • 53
    • 84979058009 scopus 로고    scopus 로고
    • Blood-brain barrier permeability in aging and Alzheimer's disease
    • Rosenberg, G. A. Blood-brain barrier permeability in aging and Alzheimer's disease. J. Prev. Alzheimers Dis. 1, 138-139 (2014).
    • (2014) J. Prev. Alzheimers Dis. , vol.1 , pp. 138-139
    • Rosenberg, G.A.1
  • 54
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy, J. & Allsop, D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 12, 383-388 (1991).
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 55
    • 84880391350 scopus 로고    scopus 로고
    • Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
    • Wardlaw, J. M. et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 12, 822-838 (2013).
    • (2013) Lancet Neurol. , vol.12 , pp. 822-838
    • Wardlaw, J.M.1
  • 56
    • 84921991249 scopus 로고    scopus 로고
    • Recommendations of the Alzheimer's Disease-Related Dementias Conference
    • Montine, T. J. et al. Recommendations of the Alzheimer's Disease-Related Dementias Conference. Neurology 83, 851-860 (2014).
    • (2014) Neurology , vol.83 , pp. 851-860
    • Montine, T.J.1
  • 57
    • 84924296638 scopus 로고    scopus 로고
    • Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
    • Snyder, H. M. et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. J. 11, 710-717 (2015).
    • (2015) Alzheimers Dement. J. , vol.11 , pp. 710-717
    • Snyder, H.M.1
  • 58
    • 84945907824 scopus 로고    scopus 로고
    • Stroke and potentially preventable dementias proclamation: Updated World Stroke Day proclamation
    • World Stroke Organization.
    • Hachinski, V. & World Stroke Organization. Stroke and potentially preventable dementias proclamation: updated World Stroke Day proclamation. Stroke 46, 3039-3040 (2015).
    • (2015) Stroke , vol.46 , pp. 3039-3040
    • Hachinski, V.1
  • 59
    • 84991226743 scopus 로고    scopus 로고
    • Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease
    • Malek, N. et al. Vascular disease and vascular risk factors in relation to motor features and cognition in early Parkinson's disease. Mov. Disord. 31, 1518-1526 (2016).
    • (2016) Mov. Disord. , vol.31 , pp. 1518-1526
    • Malek, N.1
  • 60
    • 84937730922 scopus 로고    scopus 로고
    • Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology
    • Drouin-Ouellet, J. et al. Cerebrovascular and blood-brain barrier impairments in Huntington's disease: potential implications for its pathophysiology. Ann. Neurol. 78, 160-177 (2015).
    • (2015) Ann. Neurol. , vol.78 , pp. 160-177
    • Drouin-Ouellet, J.1
  • 61
    • 84885746892 scopus 로고    scopus 로고
    • Neurovascular abnormalities in humans and mice with Huntington's disease
    • Lin, C.-Y. et al. Neurovascular abnormalities in humans and mice with Huntington's disease. Exp. Neurol. 250, 20-30 (2013).
    • (2013) Exp. Neurol. , vol.250 , pp. 20-30
    • Lin, C.-Y.1
  • 62
    • 84872363503 scopus 로고    scopus 로고
    • Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
    • Winkler, E. A. et al. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathol. 125, 111-120 (2013).
    • (2013) Acta Neuropathol. , vol.125 , pp. 111-120
    • Winkler, E.A.1
  • 63
    • 84983268540 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction as a hallmark pathology in chronic traumatic encephalopathy
    • Doherty, C. P. et al. Blood-brain barrier dysfunction as a hallmark pathology in chronic traumatic encephalopathy. J. Neuropathol. Exp. Neurol. 75, 656-662 (2016).
    • (2016) J. Neuropathol. Exp. Neurol. , vol.75 , pp. 656-662
    • Doherty, C.P.1
  • 64
    • 79958820845 scopus 로고    scopus 로고
    • Breaking down the barrier: The effects of HIV-1 on the blood-brain barrier
    • Strazza, M., Pirrone, V., Wigdahl, B. & Nonnemacher, M. R. Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier. Brain Res. 1399, 96-115 (2011).
    • (2011) Brain Res. , vol.1399 , pp. 96-115
    • Strazza, M.1    Pirrone, V.2    Wigdahl, B.3    Nonnemacher, M.R.4
  • 65
    • 84931264371 scopus 로고    scopus 로고
    • ROCKETSHIP: A flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies
    • Barnes, S. R. et al. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med. Imag. 15, 19 (2015).
    • (2015) BMC Med. Imag. , vol.15 , pp. 19
    • Barnes, S.R.1
  • 66
    • 84930897116 scopus 로고    scopus 로고
    • Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI
    • Barnes, S. R. et al. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn. Reson. Med. 75, 1967-1977 (2016).
    • (2016) Magn. Reson. Med. , vol.75 , pp. 1967-1977
    • Barnes, S.R.1
  • 67
    • 84943375348 scopus 로고    scopus 로고
    • Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes
    • Sagare, A. P., Sweeney, M. D., Makshanoff, J. & Zlokovic, B. V. Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neurosci. Lett. 607, 97-101 (2015).
    • (2015) Neurosci. Lett. , vol.607 , pp. 97-101
    • Sagare, A.P.1    Sweeney, M.D.2    Makshanoff, J.3    Zlokovic, B.V.4
  • 68
    • 84866463508 scopus 로고    scopus 로고
    • Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: A case-control study
    • Whitwell, J. L. et al. Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study. Lancet Neurol. 11, 868-877 (2012).
    • (2012) Lancet Neurol. , vol.11 , pp. 868-877
    • Whitwell, J.L.1
  • 69
    • 77952878939 scopus 로고    scopus 로고
    • Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal
    • Apostolova, L. G. et al. Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiol. Aging 31, 1077-1088 (2010).
    • (2010) Neurobiol. Aging , vol.31 , pp. 1077-1088
    • Apostolova, L.G.1
  • 70
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • Bell, R. D. et al. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427 (2010).
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1
  • 71
    • 84861418194 scopus 로고    scopus 로고
    • Apolipoprotein e controls cerebrovascular integrity via cyclophilin A
    • Bell, R. D. et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516 (2012).
    • (2012) Nature , vol.485 , pp. 512-516
    • Bell, R.D.1
  • 72
    • 84867083056 scopus 로고    scopus 로고
    • Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability
    • Winkler, E. A., Sengillo, J. D., Bell, R. D., Wang, J. & Zlokovic, B. V. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J. Cereb. Blood Flow Metab. 32, 1841-1852 (2012).
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 1841-1852
    • Winkler, E.A.1    Sengillo, J.D.2    Bell, R.D.3    Wang, J.4    Zlokovic, B.V.5
  • 73
    • 84896520534 scopus 로고    scopus 로고
    • Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice
    • Winkler, E. A. et al. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc. Natl Acad. Sci. USA 111, E1035-E1042 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E1035-E1042
    • Winkler, E.A.1
  • 74
    • 84992111543 scopus 로고    scopus 로고
    • Blood-brain barrier leakage in patients with early Alzheimer disease
    • van de Haar, H. J. et al. Blood-brain barrier leakage in patients with early Alzheimer disease. Radiology 281, 527-535 (2016).
    • (2016) Radiology , vol.281 , pp. 527-535
    • Van De Haar, H.J.1
  • 75
    • 84978946283 scopus 로고    scopus 로고
    • Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging
    • van de Haar, H. J. et al. Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging. Neurobiol. Aging 45, 190-196 (2016).
    • (2016) Neurobiol. Aging , vol.45 , pp. 190-196
    • Van De Haar, H.J.1
  • 76
    • 85022320223 scopus 로고    scopus 로고
    • Subtle blood-brain barrier leakage rate and spatial extent: Considerations for dynamic contrast-enhanced MRI
    • van de Haar, H. J. et al. Subtle blood-brain barrier leakage rate and spatial extent: considerations for dynamic contrast-enhanced MRI. Med. Phys. 44, 4112-4125 (2017).
    • (2017) Med. Phys. , vol.44 , pp. 4112-4125
    • Van De Haar, H.J.1
  • 77
    • 33748252298 scopus 로고    scopus 로고
    • Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls
    • Wang, H., Golob, E. J. & Su, M.-Y. Vascular volume and blood-brain barrier permeability measured by dynamic contrast enhanced MRI in hippocampus and cerebellum of patients with MCI and normal controls. J. Magn. Reson. Imag. 24, 695-700 (2006).
    • (2006) J. Magn. Reson. Imag. , vol.24 , pp. 695-700
    • Wang, H.1    Golob, E.J.2    Su, M.-Y.3
  • 78
    • 61349102361 scopus 로고    scopus 로고
    • Blood-brain barrier permeability in Alzheimer's disease: A case-control MRI study
    • Starr, J. M., Farrall, A. J., Armitage, P., McGurn, B. & Wardlaw, J. Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study. Psychiatry Res. 171, 232-241 (2009).
    • (2009) Psychiatry Res. , vol.171 , pp. 232-241
    • Starr, J.M.1    Farrall, A.J.2    Armitage, P.3    McGurn, B.4    Wardlaw, J.5
  • 80
    • 79952776352 scopus 로고    scopus 로고
    • Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping
    • Taheri, S., Gasparovic, C., Shah, N. J. & Rosenberg, G. A. Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping. Magn. Reson. Med. 65, 1036-1042 (2011).
    • (2011) Magn. Reson. Med. , vol.65 , pp. 1036-1042
    • Taheri, S.1    Gasparovic, C.2    Shah, N.J.3    Rosenberg, G.A.4
  • 81
    • 84891289780 scopus 로고    scopus 로고
    • Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI
    • Cramer, S. P., Simonsen, H., Frederiksen, J. L., Rostrup, E. & Larsson, H. B. W. Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI. Neuroimage Clin. 4, 182-189 (2014).
    • (2014) Neuroimage Clin. , vol.4 , pp. 182-189
    • Cramer, S.P.1    Simonsen, H.2    Frederiksen, J.L.3    Rostrup, E.4    Larsson, H.B.W.5
  • 82
    • 84940737800 scopus 로고    scopus 로고
    • Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple sclerosis
    • Cramer, S. P., Modvig, S., Simonsen, H. J., Frederiksen, J. L. & Larsson, H. B. W. Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple sclerosis. Brain J. Neurol. 138, 2571-2583 (2015).
    • (2015) Brain J. Neurol. , vol.138 , pp. 2571-2583
    • Cramer, S.P.1    Modvig, S.2    Simonsen, H.J.3    Frederiksen, J.L.4    Larsson, H.B.W.5
  • 83
    • 79960839634 scopus 로고    scopus 로고
    • Evolution of the blood-brain barrier in newly forming multiple sclerosis lesions
    • Gaitán, M. I. et al. Evolution of the blood-brain barrier in newly forming multiple sclerosis lesions. Ann. Neurol. 70, 22-29 (2011).
    • (2011) Ann. Neurol. , vol.70 , pp. 22-29
    • Gaitán, M.I.1
  • 84
    • 84858704874 scopus 로고    scopus 로고
    • Quantification of perfusion and permeability in multiple sclerosis: Dynamic contrast-enhanced MRI in 3D at 3T
    • Ingrisch, M. et al. Quantification of perfusion and permeability in multiple sclerosis: dynamic contrast-enhanced MRI in 3D at 3T. Invest. Radiol. 47, 252-258 (2012).
    • (2012) Invest. Radiol. , vol.47 , pp. 252-258
    • Ingrisch, M.1
  • 85
    • 33744811943 scopus 로고    scopus 로고
    • Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis
    • Fainardi, E. et al. Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis. Mult. Scler. 12, 294-301 (2006).
    • (2006) Mult. Scler. , vol.12 , pp. 294-301
    • Fainardi, E.1
  • 86
    • 70350548210 scopus 로고    scopus 로고
    • Patients with Alzheimer disease with multiple microbleeds: Relation with cerebrospinal fluid biomarkers and cognition
    • Goos, J. D. C. et al. Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition. Stroke 40, 3455-3460 (2009).
    • (2009) Stroke , vol.40 , pp. 3455-3460
    • Goos, J.D.C.1
  • 87
    • 84865609374 scopus 로고    scopus 로고
    • High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease
    • Brundel, M. et al. High prevalence of cerebral microbleeds at 7Tesla MRI in patients with early Alzheimer's disease. J. Alzheimers Dis. 31, 259-263 (2012).
    • (2012) J. Alzheimers Dis. , vol.31 , pp. 259-263
    • Brundel, M.1
  • 88
    • 84878506356 scopus 로고    scopus 로고
    • Prevalence and topography of small hypointense foci suggesting microbleeds on 3T susceptibility-weighted imaging in various types of dementia
    • Uetani, H. et al. Prevalence and topography of small hypointense foci suggesting microbleeds on 3T susceptibility-weighted imaging in various types of dementia. AJNR Am. J. Neuroradiol. 34, 984-989 (2013).
    • (2013) AJNR Am. J. Neuroradiol. , vol.34 , pp. 984-989
    • Uetani, H.1
  • 89
    • 84895830747 scopus 로고    scopus 로고
    • Prevalence of cortical superficial siderosis in a memory clinic population
    • Zonneveld, H. I. et al. Prevalence of cortical superficial siderosis in a memory clinic population. Neurology 82, 698-704 (2014).
    • (2014) Neurology , vol.82 , pp. 698-704
    • Zonneveld, H.I.1
  • 90
    • 84900394937 scopus 로고    scopus 로고
    • Pattern of and risk factors for brain microbleeds in neurodegenerative dementia
    • Olazarán, J. et al. Pattern of and risk factors for brain microbleeds in neurodegenerative dementia. Am. J. Alzheimers Dis. Other Demen. 29, 263-269 (2014).
    • (2014) Am. J. Alzheimers Dis. Other Demen. , vol.29 , pp. 263-269
    • Olazarán, J.1
  • 91
    • 84887259294 scopus 로고    scopus 로고
    • Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease
    • Heringa, S. M. et al. Multiple microbleeds are related to cerebral network disruptions in patients with early Alzheimer's disease. J. Alzheimers Dis. 38, 211-221 (2014).
    • (2014) J. Alzheimers Dis. , vol.38 , pp. 211-221
    • Heringa, S.M.1
  • 92
    • 84927562356 scopus 로고    scopus 로고
    • Cerebral microbleeds: Different prevalence, topography, and risk factors depending on dementia diagnosis-The Karolinska Imaging Dementia Study
    • Shams, S. et al. Cerebral microbleeds: different prevalence, topography, and risk factors depending on dementia diagnosis- the Karolinska Imaging Dementia Study. AJNR Am. J. Neuroradiol. 36, 661-666 (2015).
    • (2015) AJNR Am. J. Neuroradiol. , vol.36 , pp. 661-666
    • Shams, S.1
  • 94
    • 84902167026 scopus 로고    scopus 로고
    • Incidence of cerebral microbleeds in preclinical Alzheimer disease
    • Yates, P. A. et al. Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology 82, 1266-1273 (2014).
    • (2014) Neurology , vol.82 , pp. 1266-1273
    • Yates, P.A.1
  • 95
    • 58649115794 scopus 로고    scopus 로고
    • Cerebral microbleeds: A guide to detection and interpretation
    • Greenberg, S. M. et al. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 8, 165-174 (2009).
    • (2009) Lancet Neurol. , vol.8 , pp. 165-174
    • Greenberg, S.M.1
  • 96
    • 81555196710 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy in the elderly
    • Viswanathan, A. & Greenberg, S. M. Cerebral amyloid angiopathy in the elderly. Ann. Neurol. 70, 871-880 (2011).
    • (2011) Ann. Neurol. , vol.70 , pp. 871-880
    • Viswanathan, A.1    Greenberg, S.M.2
  • 98
    • 45149113307 scopus 로고    scopus 로고
    • Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study
    • Pettersen, J. A. et al. Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch. Neurol. 65, 790-795 (2008).
    • (2008) Arch. Neurol. , vol.65 , pp. 790-795
    • Pettersen, J.A.1
  • 99
    • 84885607112 scopus 로고    scopus 로고
    • Focal hemosiderin deposits and β-amyloid load in the ADNI cohort
    • Kantarci, K. et al. Focal hemosiderin deposits and β-amyloid load in the ADNI cohort. Alzheimers Dement. 9, S116-S123 (2013).
    • (2013) Alzheimers Dement. , vol.9 , pp. S116-S123
    • Kantarci, K.1
  • 100
    • 54049139597 scopus 로고    scopus 로고
    • Superficial siderosis: A potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease
    • Feldman, H. H. et al. Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease. Stroke 39, 2894-2897 (2008).
    • (2008) Stroke , vol.39 , pp. 2894-2897
    • Feldman, H.H.1
  • 101
    • 84954454052 scopus 로고    scopus 로고
    • Cortical superficial siderosis in memory clinic patients: Further evidence for underlying cerebral amyloid angiopathy
    • Charidimou, A. et al. Cortical superficial siderosis in memory clinic patients: further evidence for underlying cerebral amyloid angiopathy. Cerebrovasc. Dis. 41, 156-162 (2016).
    • (2016) Cerebrovasc. Dis. , vol.41 , pp. 156-162
    • Charidimou, A.1
  • 102
    • 84987662383 scopus 로고    scopus 로고
    • Cortical superficial siderosis: Prevalence and biomarker profile in a memory clinic population
    • Shams, S. et al. Cortical superficial siderosis: prevalence and biomarker profile in a memory clinic population. Neurology 87, 1110-1117 (2016).
    • (2016) Neurology , vol.87 , pp. 1110-1117
    • Shams, S.1
  • 104
    • 84951832103 scopus 로고    scopus 로고
    • Cerebral microbleeds as a biomarker in Alzheimer's disease? A review in the field
    • Shams, S. & Wahlund, L.-O. Cerebral microbleeds as a biomarker in Alzheimer's disease? A review in the field. Biomark. Med. 10, 9-18 (2016).
    • (2016) Biomark. Med. , vol.10 , pp. 9-18
    • Shams, S.1    Wahlund, L.-O.2
  • 105
    • 84906100775 scopus 로고    scopus 로고
    • Cerebral microbleeds in patients with Parkinson's disease
    • Ham, J. H. et al. Cerebral microbleeds in patients with Parkinson's disease. J. Neurol. 261, 1628-1635 (2014).
    • (2014) J. Neurol. , vol.261 , pp. 1628-1635
    • Ham, J.H.1
  • 106
    • 84947944951 scopus 로고    scopus 로고
    • Increased CSF biomarkers of angiogenesis in Parkinson disease
    • Janelidze, S. et al. Increased CSF biomarkers of angiogenesis in Parkinson disease. Neurology 85, 1834-1842 (2015).
    • (2015) Neurology , vol.85 , pp. 1834-1842
    • Janelidze, S.1
  • 107
    • 84859880865 scopus 로고    scopus 로고
    • Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: Correlating 7 Tesla MRI and pathology
    • Kwan, J. Y. et al. Iron accumulation in deep cortical layers accounts for MRI signal abnormalities in ALS: correlating 7 Tesla MRI and pathology. PLoS ONE 7, e35241 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e35241
    • Kwan, J.Y.1
  • 108
    • 84925594369 scopus 로고    scopus 로고
    • GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
    • Winkler, E. A. et al. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat. Neurosci. 18, 521-530 (2015).
    • (2015) Nat. Neurosci. , vol.18 , pp. 521-530
    • Winkler, E.A.1
  • 109
    • 0017368491 scopus 로고
    • The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat
    • Sokoloff, L. et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28, 897-916 (1977).
    • (1977) J. Neurochem. , vol.28 , pp. 897-916
    • Sokoloff, L.1
  • 110
    • 0025122107 scopus 로고
    • Use of nonradioactive 2-deoxyglucose to study compartmentation of brain glucose metabolism and rapid regional changes in rate
    • McDougal, D. B. et al. Use of nonradioactive 2-deoxyglucose to study compartmentation of brain glucose metabolism and rapid regional changes in rate. Proc. Natl Acad. Sci. USA 87, 1357-1361 (1990).
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 1357-1361
    • McDougal, D.B.1
  • 111
    • 78649962844 scopus 로고    scopus 로고
    • Brain fuel metabolism, aging, and Alzheimer's disease
    • Cunnane, S. et al. Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition 27, 3-20 (2011).
    • (2011) Nutrition , vol.27 , pp. 3-20
    • Cunnane, S.1
  • 112
    • 0001378117 scopus 로고
    • The non-competitive inhibition of brain hexokinase by glucose-6-phosphate and related compounds
    • Crane, R. K. & Sols, A. The non-competitive inhibition of brain hexokinase by glucose-6-phosphate and related compounds. J. Biol. Chem. 210, 597-606 (1954).
    • (1954) J. Biol. Chem. , vol.210 , pp. 597-606
    • Crane, R.K.1    Sols, A.2
  • 114
    • 0347286867 scopus 로고    scopus 로고
    • Tissue-specific differences in 2-fluoro-2-deoxyglucose metabolism beyond FDG-6-P: A 19F NMR spectroscopy study in the rat
    • Southworth, R., Parry, C. R., Parkes, H. G., Medina, R. A. & Garlick, P. B. Tissue-specific differences in 2-fluoro-2-deoxyglucose metabolism beyond FDG-6-P: a 19F NMR spectroscopy study in the rat. NMR Biomed. 16, 494-502 (2003).
    • (2003) NMR Biomed. , vol.16 , pp. 494-502
    • Southworth, R.1    Parry, C.R.2    Parkes, H.G.3    Medina, R.A.4    Garlick, P.B.5
  • 115
    • 0006440758 scopus 로고
    • The hexosephosphatase system; Partition of activity of glucose-6-phosphatase in the tissues [French]
    • Hers, H. G. & De Duve, C. The hexosephosphatase system; partition of activity of glucose-6-phosphatase in the tissues [French]. Bull. Soc. Chim. Biol. (Paris) 32, 20-29 (1950).
    • (1950) Bull. Soc. Chim. Biol. (Paris) , vol.32 , pp. 20-29
    • Hers, H.G.1    De Duve, C.2
  • 116
    • 0025914321 scopus 로고
    • Measurement of local cerebral glucose utilization and its relation to local functional activity in the brain
    • Sokoloff, L. Measurement of local cerebral glucose utilization and its relation to local functional activity in the brain. Adv. Exp. Med. Biol. 291, 21-42 (1991).
    • (1991) Adv. Exp. Med. Biol. , vol.291 , pp. 21-42
    • Sokoloff, L.1
  • 117
    • 0021893778 scopus 로고
    • Metabolic fluxes between [14C]2-deoxy-D-glucose and [14C]2-deoxy-D-glucose-6-phosphate in brain
    • Huang, M. T. & Veech, R. L. Metabolic fluxes between [14C]2-deoxy-D-glucose and [14C]2-deoxy-D-glucose-6-phosphate in brain in vivo. J. Neurochem. 44, 567-573 (1985).
    • (1985) In Vivo. J. Neurochem. , vol.44 , pp. 567-573
    • Huang, M.T.1    Veech, R.L.2
  • 118
    • 0028241915 scopus 로고
    • Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease
    • Simpson, I. A., Chundu, K. R., Davies-Hill, T., Honer, W. G. & Davies, P. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann. Neurol. 35, 546-551 (1994).
    • (1994) Ann. Neurol. , vol.35 , pp. 546-551
    • Simpson, I.A.1    Chundu, K.R.2    Davies-Hill, T.3    Honer, W.G.4    Davies, P.5
  • 119
    • 0030690323 scopus 로고    scopus 로고
    • GLUT-1 expression in the cerebra of patients with Alzheimer's disease
    • Mooradian, A. D., Chung, H. C. & Shah, G. N. GLUT-1 expression in the cerebra of patients with Alzheimer's disease. Neurobiol. Aging 18, 469-474 (1997).
    • (1997) Neurobiol. Aging , vol.18 , pp. 469-474
    • Mooradian, A.D.1    Chung, H.C.2    Shah, G.N.3
  • 120
    • 0024419325 scopus 로고
    • Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease
    • Kalaria, R. N. & Harik, S. I. Reduced glucose transporter at the blood-brain barrier and in cerebral cortex in Alzheimer disease. J. Neurochem. 53, 1083-1088 (1989).
    • (1989) J. Neurochem. , vol.53 , pp. 1083-1088
    • Kalaria, R.N.1    Harik, S.I.2
  • 121
    • 0027933949 scopus 로고
    • Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease
    • Horwood, N. & Davies, D. C. Immunolabelling of hippocampal microvessel glucose transporter protein is reduced in Alzheimer's disease. Virchows Arch. 425, 69-72 (1994).
    • (1994) Virchows Arch. , vol.425 , pp. 69-72
    • Horwood, N.1    Davies, D.C.2
  • 122
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Sperling, R. A. et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7, 280-292 (2011).
    • (2011) Alzheimers Dement. , vol.7 , pp. 280-292
    • Sperling, R.A.1
  • 123
    • 34249896677 scopus 로고    scopus 로고
    • Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease
    • Hunt, A. et al. Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease. Psychiatry Res. 155, 147-154 (2007).
    • (2007) Psychiatry Res. , vol.155 , pp. 147-154
    • Hunt, A.1
  • 124
    • 34748826802 scopus 로고    scopus 로고
    • Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer's disease
    • Samuraki, M. et al. Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imag. 34, 1658-1669 (2007).
    • (2007) Eur. J. Nucl. Med. Mol. Imag. , vol.34 , pp. 1658-1669
    • Samuraki, M.1
  • 125
    • 40449083016 scopus 로고    scopus 로고
    • Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias
    • Mosconi, L. et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. J. Nucl. Med. 49, 390-398 (2008).
    • (2008) J. Nucl. Med. , vol.49 , pp. 390-398
    • Mosconi, L.1
  • 126
    • 33947261376 scopus 로고    scopus 로고
    • Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease
    • Mosconi, L. et al. Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. J. Nucl. Med. 47, 1778-1786 (2006).
    • (2006) J. Nucl. Med. , vol.47 , pp. 1778-1786
    • Mosconi, L.1
  • 127
    • 79958766587 scopus 로고    scopus 로고
    • Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI
    • Landau, S. M. et al. Associations between cognitive, functional, and FDG-PET measures of decline in AD and MCI. Neurobiol. Aging 32, 1207-1218 (2011).
    • (2011) Neurobiol. Aging , vol.32 , pp. 1207-1218
    • Landau, S.M.1
  • 128
    • 84940888293 scopus 로고    scopus 로고
    • Precuneus and cingulate cortex atrophy and hypometabolism in patients with Alzheimer's disease and mild cognitive impairment: MRI and 18F-FDG PET quantitative analysis using FreeSurfer
    • Bailly, M. et al. Precuneus and cingulate cortex atrophy and hypometabolism in patients with Alzheimer's disease and mild cognitive impairment: MRI and 18F-FDG PET quantitative analysis using FreeSurfer. Biomed. Res. Int. 2015, 583931 (2015).
    • (2015) Biomed. Res. Int. , vol.2015 , pp. 583931
    • Bailly, M.1
  • 129
    • 84873672546 scopus 로고    scopus 로고
    • Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
    • Ossenkoppele, R. et al. Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia. Neurology 80, 359-365 (2013).
    • (2013) Neurology , vol.80 , pp. 359-365
    • Ossenkoppele, R.1
  • 130
    • 84874912869 scopus 로고    scopus 로고
    • Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease
    • Protas, H. D. et al. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA Neurol. 70, 320-325 (2013).
    • (2013) JAMA Neurol. , vol.70 , pp. 320-325
    • Protas, H.D.1
  • 131
    • 84868159914 scopus 로고    scopus 로고
    • Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
    • Mosconi, L. et al. Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents. Neurobiol. Aging 34, 22-34 (2013).
    • (2013) Neurobiol. Aging , vol.34 , pp. 22-34
    • Mosconi, L.1
  • 132
    • 77954981027 scopus 로고    scopus 로고
    • Comparing predictors of conversion and decline in mild cognitive impairment
    • Landau, S. M. et al. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology 75, 230-238 (2010).
    • (2010) Neurology , vol.75 , pp. 230-238
    • Landau, S.M.1
  • 133
    • 64649097658 scopus 로고    scopus 로고
    • FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
    • Mosconi, L. et al. FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imag. 36, 811-822 (2009).
    • (2009) Eur. J. Nucl. Med. Mol. Imag. , vol.36 , pp. 811-822
    • Mosconi, L.1
  • 134
    • 0036176504 scopus 로고    scopus 로고
    • Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
    • Niwa, K., Kazama, K., Younkin, S. G., Carlson, G. A. & Iadecola, C. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol. Dis. 9, 61-68 (2002).
    • (2002) Neurobiol. Dis. , vol.9 , pp. 61-68
    • Niwa, K.1    Kazama, K.2    Younkin, S.G.3    Carlson, G.A.4    Iadecola, C.5
  • 135
    • 0026073417 scopus 로고
    • Diminished glucose transport in Alzheimer's disease: Dynamic PET studies
    • Jagust, W. J. et al. Diminished glucose transport in Alzheimer's disease: dynamic PET studies. J. Cereb. Blood Flow Metab. 11, 323-330 (1991).
    • (1991) J. Cereb. Blood Flow Metab. , vol.11 , pp. 323-330
    • Jagust, W.J.1
  • 136
    • 0029874365 scopus 로고    scopus 로고
    • Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET
    • Piert, M., Koeppe, R. A., Giordani, B., Berent, S. & Kuhl, D. E. Diminished glucose transport and phosphorylation in Alzheimer's disease determined by dynamic FDG-PET. J. Nucl. Med. 37, 201-208 (1996).
    • (1996) J. Nucl. Med. , vol.37 , pp. 201-208
    • Piert, M.1    Koeppe, R.A.2    Giordani, B.3    Berent, S.4    Kuhl, D.E.5
  • 137
    • 27644489474 scopus 로고    scopus 로고
    • P-Glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model
    • Cirrito, J. R. et al. P-Glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model. J. Clin. Invest. 115, 3285-3290 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 3285-3290
    • Cirrito, J.R.1
  • 138
    • 84966326696 scopus 로고    scopus 로고
    • A role for P-glycoprotein in clearance of Alzheimer amyloid β-peptide from the brain
    • Wang, W., Bodles-Brakhop, A. M. & Barger, S. W. A role for P-glycoprotein in clearance of Alzheimer amyloid β-peptide from the brain. Curr. Alzheimer Res. 13, 615-620 (2016).
    • (2016) Curr. Alzheimer Res. , vol.13 , pp. 615-620
    • Wang, W.1    Bodles-Brakhop, A.M.2    Barger, S.W.3
  • 139
    • 85018329287 scopus 로고    scopus 로고
    • Neurovascular alterations in Alzheimer's disease: Transporter expression profiles and CNS drug access
    • McInerney, M. P., Short, J. L. & Nicolazzo, J. A. Neurovascular alterations in Alzheimer's disease: transporter expression profiles and CNS drug access. AAPS J. 19, 940-956 (2017).
    • (2017) AAPS J. , vol.19 , pp. 940-956
    • McInerney, M.P.1    Short, J.L.2    Nicolazzo, J.A.3
  • 140
    • 84863393540 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function in Alzheimer's disease
    • van Assema, D. M. E. et al. Blood-brain barrier P-glycoprotein function in Alzheimer's disease. Brain J. Neurol. 135, 181-189 (2012).
    • (2012) Brain J. Neurol. , vol.135 , pp. 181-189
    • Van Assema, D.M.E.1
  • 141
    • 84904100818 scopus 로고    scopus 로고
    • Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease
    • Deo, A. K. et al. Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease. J. Nucl. Med. 55, 1106-1111 (2014).
    • (2014) J. Nucl. Med. , vol.55 , pp. 1106-1111
    • Deo, A.K.1
  • 142
    • 13144255682 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction in parkinsonian midbrain
    • Kortekaas, R. et al. Blood-brain barrier dysfunction in parkinsonian midbrain in vivo. Ann. Neurol 57, 176-179 (2005).
    • (2005) In Vivo. Ann. Neurol , vol.57 , pp. 176-179
    • Kortekaas, R.1
  • 143
    • 84996565805 scopus 로고    scopus 로고
    • Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier
    • Gerwien, H. et al. Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier. Sci. Transl Med. 8, 364ra152 (2016).
    • (2016) Sci. Transl Med. , vol.8 , pp. 364ra152
    • Gerwien, H.1
  • 144
    • 65749100483 scopus 로고    scopus 로고
    • The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis
    • Zamboni, P. et al. The value of cerebral Doppler venous haemodynamics in the assessment of multiple sclerosis. J. Neurol. Sci. 282, 21-27 (2009).
    • (2009) J. Neurol. Sci. , vol.282 , pp. 21-27
    • Zamboni, P.1
  • 145
    • 84907992737 scopus 로고    scopus 로고
    • Impaired cerebrovascular reactivity in multiple sclerosis
    • Marshall, O. et al. Impaired cerebrovascular reactivity in multiple sclerosis. JAMA Neurol. 71, 1275-1281 (2014).
    • (2014) JAMA Neurol. , vol.71 , pp. 1275-1281
    • Marshall, O.1
  • 146
    • 28044448943 scopus 로고    scopus 로고
    • Pericapillary haem-rich deposits: Evidence for microhaemorrhages in aging human cerebral cortex
    • Cullen, K. M., Kósi, Z. & Stone, J. Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex. J. Cereb. Blood Flow Metab. 25, 1656-1667 (2005).
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 1656-1667
    • Cullen, K.M.1    Kósi, Z.2    Stone, J.3
  • 147
    • 84881181605 scopus 로고    scopus 로고
    • The APOE ϵ4/ϵ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients
    • Hultman, K., Strickland, S. & Norris, E. H. The APOE ϵ4/ϵ4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients. J. Cereb. Blood Flow Metab. 33, 1251-1258 (2013).
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , pp. 1251-1258
    • Hultman, K.1    Strickland, S.2    Norris, E.H.3
  • 148
    • 84939000054 scopus 로고    scopus 로고
    • Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin
    • Zenaro, E. et al. Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin. Nat. Med. 21, 880-886 (2015).
    • (2015) Nat. Med. , vol.21 , pp. 880-886
    • Zenaro, E.1
  • 149
    • 0037000396 scopus 로고    scopus 로고
    • Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier
    • Fiala, M. et al. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. Eur. J. Clin. Invest. 32, 360-371 (2002).
    • (2002) Eur. J. Clin. Invest. , vol.32 , pp. 360-371
    • Fiala, M.1
  • 150
    • 33745094734 scopus 로고    scopus 로고
    • Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)
    • Persidsky, Y. et al. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood 107, 4770-4780 (2006).
    • (2006) Blood , vol.107 , pp. 4770-4780
    • Persidsky, Y.1
  • 151
    • 77956400763 scopus 로고    scopus 로고
    • Chronic traumatic encephalopathy in a professional American wrestler
    • Omalu, B. I., Fitzsimmons, R. P., Hammers, J. & Bailes, J. Chronic traumatic encephalopathy in a professional American wrestler. J. Forens. Nurs. 6, 130-136 (2010).
    • (2010) J. Forens. Nurs. , vol.6 , pp. 130-136
    • Omalu, B.I.1    Fitzsimmons, R.P.2    Hammers, J.3    Bailes, J.4
  • 152
    • 34247343262 scopus 로고    scopus 로고
    • Microvascular injury and blood-brain barrier leakage in Alzheimer's disease
    • Zipser, B. D. et al. Microvascular injury and blood-brain barrier leakage in Alzheimer's disease. Neurobiol. Aging 28, 977-986 (2007).
    • (2007) Neurobiol. Aging , vol.28 , pp. 977-986
    • Zipser, B.D.1
  • 153
    • 72849106266 scopus 로고    scopus 로고
    • A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain
    • Ryu, J. K. & McLarnon, J. G. A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J. Cell. Mol. Med. 13, 2911-2925 (2009).
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 2911-2925
    • Ryu, J.K.1    McLarnon, J.G.2
  • 154
    • 77953679700 scopus 로고    scopus 로고
    • Fibrinogen and β-amyloid association alters thrombosis and fibrinolysis: A possible contributing factor to Alzheimer's disease
    • Cortes-Canteli, M. et al. Fibrinogen and β-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease. Neuron 66, 695-709 (2010).
    • (2010) Neuron , vol.66 , pp. 695-709
    • Cortes-Canteli, M.1
  • 155
    • 84876288324 scopus 로고    scopus 로고
    • Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease
    • Sengillo, J. D. et al. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol. 23, 303-310 (2013).
    • (2013) Brain Pathol. , vol.23 , pp. 303-310
    • Sengillo, J.D.1
  • 156
    • 84951568640 scopus 로고    scopus 로고
    • Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease
    • Halliday, M. R. et al. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J. Cereb. Blood Flow Metab. 36, 216-227 (2016).
    • (2016) J. Cereb. Blood Flow Metab. , vol.36 , pp. 216-227
    • Halliday, M.R.1
  • 157
    • 85039851085 scopus 로고    scopus 로고
    • Differing associations between Aβ accumulation, hypoperfusion, blood-brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease
    • Miners, J. S., Schulz, I. & Love, S. Differing associations between Aβ accumulation, hypoperfusion, blood-brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease. J. Cereb. Blood Flow Metab. http:// dx.doi.org/10.1177/0271678X17690761 (2017).
    • (2017) J. Cereb. Blood Flow Metab.
    • Miners, J.S.1    Schulz, I.2    Love, S.3
  • 158
    • 17744409878 scopus 로고    scopus 로고
    • Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease
    • Salloway, S. et al. Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease. J. Neurol. Sci. 203-204, 183-187 (2002).
    • (2002) J. Neurol. Sci. , vol.203-204 , pp. 183-187
    • Salloway, S.1
  • 159
    • 84890576583 scopus 로고    scopus 로고
    • Pericyte loss influences Alzheimer-like neurodegeneration in mice
    • Sagare, A. P. et al. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat. Commun. 4, 2932 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2932
    • Sagare, A.P.1
  • 160
    • 84874263603 scopus 로고    scopus 로고
    • Innate immunity receptor CD36 promotes cerebral amyloid angiopathy
    • Park, L. et al. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc. Natl Acad. Sci. USA 110, 3089-3094 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 3089-3094
    • Park, L.1
  • 161
    • 84922681924 scopus 로고    scopus 로고
    • Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with LiraglutideTM
    • Kelly, P. et al. Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with LiraglutideTM. Microcirculation 22, 133-145 (2015).
    • (2015) Microcirculation , vol.22 , pp. 133-145
    • Kelly, P.1
  • 162
    • 84987906247 scopus 로고    scopus 로고
    • Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway
    • Park, J.-C. et al. Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway. Aging Cell 16, 149-161 (2017).
    • (2017) Aging Cell , vol.16 , pp. 149-161
    • Park, J.-C.1
  • 163
    • 84920686030 scopus 로고    scopus 로고
    • Human apolipoprotein e ϵ4 expression impairs cerebral vascularization and blood-brain barrier function in mice
    • Alata, W., Ye, Y., St-Amour, I., Vandal, M. & Calon, F. Human apolipoprotein E ϵ4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J. Cereb. Blood Flow Metab. 35, 86-94 (2015).
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 86-94
    • Alata, W.1    Ye, Y.2    St-Amour, I.3    Vandal, M.4    Calon, F.5
  • 164
    • 79955953909 scopus 로고    scopus 로고
    • Apolipoprotein e regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model
    • Nishitsuji, K., Hosono, T., Nakamura, T., Bu, G. & Michikawa, M. Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model. J. Biol. Chem. 286, 17536-17542 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 17536-17542
    • Nishitsuji, K.1    Hosono, T.2    Nakamura, T.3    Bu, G.4    Michikawa, M.5
  • 165
    • 84928825095 scopus 로고    scopus 로고
    • Striatal blood-brain barrier permeability in Parkinson's disease
    • Gray, M. T. & Woulfe, J. M. Striatal blood-brain barrier permeability in Parkinson's disease. J. Cereb. Blood Flow Metab. 35, 747-750 (2015).
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 747-750
    • Gray, M.T.1    Woulfe, J.M.2
  • 166
    • 84923623232 scopus 로고    scopus 로고
    • Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease
    • Pienaar, I. S. et al. Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease. Neurobiol. Dis. 74, 392-405 (2015).
    • (2015) Neurobiol. Dis. , vol.74 , pp. 392-405
    • Pienaar, I.S.1
  • 167
    • 0029153619 scopus 로고
    • Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions
    • Loeffler, D. A. et al. Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J. Neurochem. 65, 710-724 (1995).
    • (1995) J. Neurochem. , vol.65 , pp. 710-724
    • Loeffler, D.A.1
  • 168
    • 84864775702 scopus 로고    scopus 로고
    • Impaired blood-brain/spinal cord barrier in ALS patients
    • Garbuzova-Davis, S. et al. Impaired blood-brain/spinal cord barrier in ALS patients. Brain Res. 1469, 114-128 (2012).
    • (2012) Brain Res. , vol.1469 , pp. 114-128
    • Garbuzova-Davis, S.1
  • 169
    • 41149097086 scopus 로고    scopus 로고
    • ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
    • Zhong, Z. et al. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat. Neurosci. 11, 420-422 (2008).
    • (2008) Nat. Neurosci. , vol.11 , pp. 420-422
    • Zhong, Z.1
  • 170
    • 0141926694 scopus 로고    scopus 로고
    • Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    • Kirk, J., Plumb, J., Mirakhur, M. & McQuaid, S. Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. J. Pathol. 201, 319-327 (2003).
    • (2003) J. Pathol. , vol.201 , pp. 319-327
    • Kirk, J.1    Plumb, J.2    Mirakhur, M.3    McQuaid, S.4
  • 171
    • 21744460676 scopus 로고    scopus 로고
    • Chronic traumatic encephalopathy in a National Football League player
    • Omalu, B. I. et al. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 57, 128-134 (2005).
    • (2005) Neurosurgery , vol.57 , pp. 128-134
    • Omalu, B.I.1
  • 172
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • Farkas, E. & Luiten, P. G. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 64, 575-611 (2001).
    • (2001) Prog. Neurobiol. , vol.64 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.2
  • 173
    • 84867581572 scopus 로고    scopus 로고
    • The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy
    • Baloyannis, S. J. & Baloyannis, I. S. The vascular factor in Alzheimer's disease: a study in Golgi technique and electron microscopy. J. Neurol. Sci. 322, 117-121 (2012).
    • (2012) J. Neurol. Sci. , vol.322 , pp. 117-121
    • Baloyannis, S.J.1    Baloyannis, I.S.2
  • 174
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • Winkler, E. A., Bell, R. D. & Zlokovic, B. V. Central nervous system pericytes in health and disease. Nat. Neurosci. 14, 1398-1405 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 175
    • 78649467527 scopus 로고    scopus 로고
    • Pericytes regulate the blood-brain barrier
    • Armulik, A. et al. Pericytes regulate the blood-brain barrier. Nature 468, 557-561 (2010).
    • (2010) Nature , vol.468 , pp. 557-561
    • Armulik, A.1
  • 176
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • Daneman, R., Zhou, L., Kebede, A. A. & Barres, B. A. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468, 562-566 (2010).
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 177
    • 84906545643 scopus 로고    scopus 로고
    • Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: Implications for human immunodeficiency virus-associated neurocognitive disorders
    • Niu, F., Yao, H., Zhang, W., Sutliff, R. L. & Buch, S. Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders. J. Neurosci. 34, 11812-11825 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 11812-11825
    • Niu, F.1    Yao, H.2    Zhang, W.3    Sutliff, R.L.4    Buch, S.5
  • 178
    • 84879915916 scopus 로고    scopus 로고
    • Neurochemical profile of dementia pugilistica
    • Kokjohn, T. A. et al. Neurochemical profile of dementia pugilistica. J. Neurotrauma 30, 981-997 (2013).
    • (2013) J. Neurotrauma , vol.30 , pp. 981-997
    • Kokjohn, T.A.1
  • 179
    • 3042836549 scopus 로고    scopus 로고
    • The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease
    • Bailey, T. L., Rivara, C. B., Rocher, A. B. & Hof, P. R. The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease. Neurol. Res. 26, 573-578 (2004).
    • (2004) Neurol. Res. , vol.26 , pp. 573-578
    • Bailey, T.L.1    Rivara, C.B.2    Rocher, A.B.3    Hof, P.R.4
  • 180
    • 24744457932 scopus 로고    scopus 로고
    • Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
    • Wu, Z. et al. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat. Med. 11, 959-965 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 959-965
    • Wu, Z.1
  • 181
    • 80055063239 scopus 로고    scopus 로고
    • Brain microvasculature and hypoxia-related proteins in Alzheimer's disease
    • Grammas, P., Tripathy, D., Sanchez, A., Yin, X. & Luo, J. Brain microvasculature and hypoxia-related proteins in Alzheimer's disease. Int. J. Clin. Exp. Pathol. 4, 616-627 (2011).
    • (2011) Int. J. Clin. Exp. Pathol. , vol.4 , pp. 616-627
    • Grammas, P.1    Tripathy, D.2    Sanchez, A.3    Yin, X.4    Luo, J.5
  • 182
    • 67649391341 scopus 로고    scopus 로고
    • Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS
    • Henkel, J. S., Beers, D. R., Wen, S., Bowser, R. & Appel, S. H. Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS. Neurology 72, 1614-1616 (2009).
    • (2009) Neurology , vol.72 , pp. 1614-1616
    • Henkel, J.S.1    Beers, D.R.2    Wen, S.3    Bowser, R.4    Appel, S.H.5
  • 183
    • 79952499042 scopus 로고    scopus 로고
    • Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis
    • Miyazaki, K. et al. Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis. J. Neurosci. Res. 89, 718-728 (2011).
    • (2011) J. Neurosci. Res. , vol.89 , pp. 718-728
    • Miyazaki, K.1
  • 184
    • 39549112926 scopus 로고    scopus 로고
    • Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells
    • Yamamoto, M. et al. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am. J. Pathol. 172, 521-533 (2008).
    • (2008) Am. J. Pathol. , vol.172 , pp. 521-533
    • Yamamoto, M.1
  • 185
    • 84970948063 scopus 로고    scopus 로고
    • Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease
    • Kumar, D. K. V. et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease. Sci. Transl Med. 8, 340ra72 (2016).
    • (2016) Sci. Transl Med. , vol.8 , pp. 340ra72
    • Kumar, D.K.V.1
  • 186
    • 77949830350 scopus 로고    scopus 로고
    • The Alzheimer's disease-associated amyloid β-protein is an antimicrobial peptide
    • Soscia, S. J. et al. The Alzheimer's disease-associated amyloid β-protein is an antimicrobial peptide. PLoS ONE 5, e9505 (2010).
    • (2010) PLoS ONE , vol.5 , pp. e9505
    • Soscia, S.J.1
  • 187
    • 33745457691 scopus 로고    scopus 로고
    • Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease
    • Wada, K. et al. Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease. Neuroreport 17, 705-709 (2006).
    • (2006) Neuroreport , vol.17 , pp. 705-709
    • Wada, K.1
  • 188
    • 84857624257 scopus 로고    scopus 로고
    • Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy
    • Desai Bradaric, B., Patel, A., Schneider, J. A., Carvey, P. M. & Hendey, B. Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy. J. Neural Transm. 119, 59-71 (2012).
    • (2012) J. Neural Transm. , vol.119 , pp. 59-71
    • Desai Bradaric, B.1    Patel, A.2    Schneider, J.A.3    Carvey, P.M.4    Hendey, B.5
  • 189
    • 84872535858 scopus 로고    scopus 로고
    • Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease
    • Hill, K. K. et al. Cerebral blood flow responses to dorsal and ventral STN DBS correlate with gait and balance responses in Parkinson's disease. Exp. Neurol. 241, 105-112 (2013).
    • (2013) Exp. Neurol. , vol.241 , pp. 105-112
    • Hill, K.K.1
  • 190
    • 33749157416 scopus 로고    scopus 로고
    • RAGE, LRP-1, and amyloid-β protein in Alzheimer's disease
    • Donahue, J. E. et al. RAGE, LRP-1, and amyloid-β protein in Alzheimer's disease. Acta Neuropathol. 112, 405-415 (2006).
    • (2006) Acta Neuropathol. , vol.112 , pp. 405-415
    • Donahue, J.E.1
  • 191
    • 54049094343 scopus 로고    scopus 로고
    • Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    • Miller, M. C. et al. Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease. Brain Res. 1230, 273-280 (2008).
    • (2008) Brain Res. , vol.1230 , pp. 273-280
    • Miller, M.C.1
  • 192
    • 84865575547 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities
    • Sagare, A. P., Deane, R. & Zlokovic, B. V. Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol. Ther. 136, 94-105 (2012).
    • (2012) Pharmacol. Ther. , vol.136 , pp. 94-105
    • Sagare, A.P.1    Deane, R.2    Zlokovic, B.V.3
  • 193
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-β efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B., Bales, K. R., Cummins, D. J., Paul, S. M. & Holtzman, D. M. Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295, 2264-2267 (2002).
    • (2002) Science , vol.295 , pp. 2264-2267
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 194
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B. et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 98, 8850-8855 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1
  • 195
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02008357 (2017).
    • (2017) ClinicalTrials.gov
  • 196
    • 0037703255 scopus 로고    scopus 로고
    • RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
    • Deane, R. et al. RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9, 907-913 (2003).
    • (2003) Nat. Med. , vol.9 , pp. 907-913
    • Deane, R.1
  • 197
    • 0013615899 scopus 로고    scopus 로고
    • RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
    • Yan, S. D. et al. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382, 685-691 (1996).
    • (1996) Nature , vol.382 , pp. 685-691
    • Yan, S.D.1
  • 198
    • 0032529151 scopus 로고    scopus 로고
    • Human blood-brain barrier receptors for Alzheimer's amyloid-β1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
    • Mackic, J. B. et al. Human blood-brain barrier receptors for Alzheimer's amyloid-β1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J. Clin. Invest. 102, 734-743 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 734-743
    • Mackic, J.B.1
  • 199
    • 84859723641 scopus 로고    scopus 로고
    • A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease
    • Deane, R. et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122, 1377-1392 (2012).
    • (2012) J. Clin. Invest. , vol.122 , pp. 1377-1392
    • Deane, R.1
  • 200
    • 37249013214 scopus 로고    scopus 로고
    • US National Library of Medicine
    • US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT02916056 (2017).
    • (2017) ClinicalTrials.gov
  • 201
    • 84883796045 scopus 로고    scopus 로고
    • Relationship between cyclophilin A levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown
    • Halliday, M. R. et al. Relationship between cyclophilin A levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 70, 1198-1200 (2013).
    • (2013) JAMA Neurol. , vol.70 , pp. 1198-1200
    • Halliday, M.R.1
  • 202
    • 84926254510 scopus 로고    scopus 로고
    • APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms
    • Conejero-Goldberg, C. et al. APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms. Mol. Psychiatry 19, 1243-1250 (2014).
    • (2014) Mol. Psychiatry , vol.19 , pp. 1243-1250
    • Conejero-Goldberg, C.1
  • 203
    • 84940788102 scopus 로고    scopus 로고
    • Randomised clinical trial: Alisporivir combined with peginterferon and ribavirin in treatment-naive patients with chronic HCV genotype 1 infection (ESSENTIAL II)
    • Zeuzem, S. et al. Randomised clinical trial: alisporivir combined with peginterferon and ribavirin in treatment-naive patients with chronic HCV genotype 1 infection (ESSENTIAL II). Aliment. Pharmacol. Ther. 42, 829-844 (2015).
    • (2015) Aliment. Pharmacol. Ther. , vol.42 , pp. 829-844
    • Zeuzem, S.1
  • 204
    • 5644300853 scopus 로고    scopus 로고
    • Altered P-glycoprotein expression in AIDS patients with HIV encephalitis
    • Langford, D. et al. Altered P-glycoprotein expression in AIDS patients with HIV encephalitis. J. Neuropathol. Exp. Neurol. 63, 1038-1047 (2004).
    • (2004) J. Neuropathol. Exp. Neurol. , vol.63 , pp. 1038-1047
    • Langford, D.1
  • 205
    • 84904787076 scopus 로고    scopus 로고
    • Mutant huntingtin is present in neuronal grafts in Huntington disease patients
    • Cicchetti, F. et al. Mutant huntingtin is present in neuronal grafts in Huntington disease patients. Ann. Neurol. 76, 31-42 (2014).
    • (2014) Ann. Neurol. , vol.76 , pp. 31-42
    • Cicchetti, F.1
  • 206
    • 84885018413 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease
    • Erickson, M. A. & Banks, W. A. Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. J. Cereb. Blood Flow Metab. 33, 1500-1513 (2013).
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , pp. 1500-1513
    • Erickson, M.A.1    Banks, W.A.2
  • 207
    • 84902536614 scopus 로고    scopus 로고
    • Inflammatory mediators as biomarkers in brain disorders
    • Nuzzo, D. et al. Inflammatory mediators as biomarkers in brain disorders. Inflammation 37, 639-648 (2014).
    • (2014) Inflammation , vol.37 , pp. 639-648
    • Nuzzo, D.1
  • 208
    • 0031922362 scopus 로고    scopus 로고
    • A population study on blood-brain barrier function in 85-year-olds: Relation to Alzheimer's disease and vascular dementia
    • Skoog, I. et al. A population study on blood-brain barrier function in 85-year-olds: relation to Alzheimer's disease and vascular dementia. Neurology 50, 966-971 (1998).
    • (1998) Neurology , vol.50 , pp. 966-971
    • Skoog, I.1
  • 209
    • 85007609372 scopus 로고    scopus 로고
    • Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype
    • Janelidze, S. et al. Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype. Neurobiol. Aging 51, 104-112 (2017).
    • (2017) Neurobiol. Aging , vol.51 , pp. 104-112
    • Janelidze, S.1
  • 210
    • 85026625803 scopus 로고    scopus 로고
    • CSF/serum albumin ratio in dementias: A cross-sectional study on 1,861 patients
    • Skillback, T. et al. CSF/serum albumin ratio in dementias: a cross-sectional study on 1,861 patients. Neurobiol. Aging 59, 1-9 (2017).
    • (2017) Neurobiol. Aging , vol.59 , pp. 1-9
    • Skillback, T.1
  • 211
    • 0025339140 scopus 로고
    • Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors
    • Blennow, K. et al. Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors. Acta Neurol. Scand. 81, 323-326 (1990).
    • (1990) Acta Neurol. Scand. , vol.81 , pp. 323-326
    • Blennow, K.1
  • 212
    • 0033202419 scopus 로고    scopus 로고
    • Cerebrospinal fluid markers of pathogenetic processes in vascular dementia, with special reference to the subcortical subtype
    • Wallin, A., Blennow, K. & Rosengren, L. Cerebrospinal fluid markers of pathogenetic processes in vascular dementia, with special reference to the subcortical subtype. Alzheimer Dis. Assoc. Disord. 13 (Suppl. 3), S102-S105 (1999).
    • (1999) Alzheimer Dis. Assoc. Disord. , vol.13 , pp. S102-S105
    • Wallin, A.1    Blennow, K.2    Rosengren, L.3
  • 213
    • 0025978236 scopus 로고
    • White-matter lesions on CT in Alzheimer patients: Relation to clinical symptomatology and vascular factors
    • Blennow, K., Wallin, A., Uhlemann, C. & Gottfries, C. G. White-matter lesions on CT in Alzheimer patients: relation to clinical symptomatology and vascular factors. Acta Neurol. Scand. 83, 187-193 (1991).
    • (1991) Acta Neurol. Scand. , vol.83 , pp. 187-193
    • Blennow, K.1    Wallin, A.2    Uhlemann, C.3    Gottfries, C.G.4
  • 214
    • 84862278854 scopus 로고    scopus 로고
    • Dyslipidemia and blood-brain barrier integrity in Alzheimer's disease
    • Bowman, G. L., Kaye, J. A. & Quinn, J. F. Dyslipidemia and blood-brain barrier integrity in Alzheimer's disease. Curr. Gerontol. Geriatr. Res. 2012, 184042 (2012).
    • (2012) Curr. Gerontol. Geriatr. Res. , vol.2012 , pp. 184042
    • Bowman, G.L.1    Kaye, J.A.2    Quinn, J.F.3
  • 215
    • 84886389767 scopus 로고    scopus 로고
    • Hypertension: A harbinger of stroke and dementia
    • Faraco, G. & Iadecola, C. Hypertension: a harbinger of stroke and dementia. Hypertension 62, 810-817 (2013).
    • (2013) Hypertension , vol.62 , pp. 810-817
    • Faraco, G.1    Iadecola, C.2
  • 216
    • 33846623307 scopus 로고    scopus 로고
    • TGF-β receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis
    • Ivens, S. et al. TGF-β receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis. Brain 130, 535-547 (2007).
    • (2007) Brain , vol.130 , pp. 535-547
    • Ivens, S.1
  • 217
    • 84869090786 scopus 로고    scopus 로고
    • Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling
    • Braganza, O. et al. Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling. Epilepsia 53, 1898-1906 (2012).
    • (2012) Epilepsia , vol.53 , pp. 1898-1906
    • Braganza, O.1
  • 218
    • 84979658361 scopus 로고    scopus 로고
    • Albumin and multiple sclerosis
    • LeVine, S. M. Albumin and multiple sclerosis. BMC Neurol. 16, 47 (2016).
    • (2016) BMC Neurol. , vol.16 , pp. 47
    • LeVine, S.M.1
  • 219
    • 0035960650 scopus 로고    scopus 로고
    • The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type
    • Silverberg, G. D. et al. The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type. Neurology 57, 1763-1766 (2001).
    • (2001) Neurology , vol.57 , pp. 1763-1766
    • Silverberg, G.D.1
  • 220
    • 79955431733 scopus 로고    scopus 로고
    • Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis
    • Craig-Schapiro, R. et al. Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis. PLoS ONE 6, e18850 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e18850
    • Craig-Schapiro, R.1
  • 221
    • 84901928902 scopus 로고    scopus 로고
    • Analysis of matrix metallo-proteases and the plasminogen system in mild cognitive impairment and Alzheimer's disease cerebrospinal fluid
    • Hanzel, C. E. et al. Analysis of matrix metallo-proteases and the plasminogen system in mild cognitive impairment and Alzheimer's disease cerebrospinal fluid. J. Alzheimers Dis. 40, 667-678 (2014).
    • (2014) J. Alzheimers Dis. , vol.40 , pp. 667-678
    • Hanzel, C.E.1
  • 222
    • 84864542583 scopus 로고    scopus 로고
    • Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease
    • Pisani, V. et al. Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease. J. Neuroinflamm. 9, 188 (2012).
    • (2012) J. Neuroinflamm. , vol.9 , pp. 188
    • Pisani, V.1
  • 223
    • 85038260326 scopus 로고    scopus 로고
    • Cerebrospinal-fluid Alzheimer's disease biomarkers and blood-brain barrier integrity in a natural population of cognitive intact Parkinson's disease patients
    • Liguori, C. et al. Cerebrospinal-fluid Alzheimer's disease biomarkers and blood-brain barrier integrity in a natural population of cognitive intact Parkinson's disease patients. CNS Neurol. Disord. Drug Targets 16, 339-345 (2017).
    • (2017) CNS Neurol. Disord. Drug Targets , vol.16 , pp. 339-345
    • Liguori, C.1
  • 225
    • 84895558897 scopus 로고    scopus 로고
    • Biomarker evidence of axonal injury in neuroasymptomatic HIV-1 patients
    • Jessen Krut, J. et al. Biomarker evidence of axonal injury in neuroasymptomatic HIV-1 patients. PLoS ONE 9, e88591 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e88591
    • Jessen Krut, J.1
  • 226
    • 0031470554 scopus 로고    scopus 로고
    • Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
    • Chen, Z. L. & Strickland, S. Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 91, 917-925 (1997).
    • (1997) Cell , vol.91 , pp. 917-925
    • Chen, Z.L.1    Strickland, S.2
  • 227
    • 2542561236 scopus 로고    scopus 로고
    • Thrombin, a mediator of neurotoxicity and memory impairment
    • Mhatre, M. et al. Thrombin, a mediator of neurotoxicity and memory impairment. Neurobiol. Aging 25, 783-793 (2004).
    • (2004) Neurobiol. Aging , vol.25 , pp. 783-793
    • Mhatre, M.1
  • 228
    • 77958001457 scopus 로고    scopus 로고
    • Thrombin mediates severe neurovascular injury during ischemia
    • Chen, B., Cheng, Q., Yang, K. & Lyden, P. D. Thrombin mediates severe neurovascular injury during ischemia. Stroke 41, 2348-2352 (2010).
    • (2010) Stroke , vol.41 , pp. 2348-2352
    • Chen, B.1    Cheng, Q.2    Yang, K.3    Lyden, P.D.4
  • 229
    • 34547415988 scopus 로고    scopus 로고
    • Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor
    • Schachtrup, C. et al. Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated phosphorylation of the EGF receptor. Proc. Natl Acad. Sci. USA 104, 11814-11819 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 11814-11819
    • Schachtrup, C.1
  • 230
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • Paul, J., Strickland, S. & Melchor, J. P. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J. Exp. Med. 204, 1999-2008 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 231
    • 2342570412 scopus 로고    scopus 로고
    • Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis
    • Akassoglou, K. et al. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc. Natl Acad. Sci. USA 101, 6698-6703 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 6698-6703
    • Akassoglou, K.1
  • 232
    • 84941578601 scopus 로고    scopus 로고
    • Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation
    • Ryu, J. K. et al. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat. Commun. 6, 8164 (2015).
    • (2015) Nat. Commun. , vol.6 , pp. 8164
    • Ryu, J.K.1
  • 233
    • 84942929066 scopus 로고    scopus 로고
    • Breaking boundaries- coagulation and fibrinolysis at the neurovascular interface
    • Bardehle, S., Rafalski, V. A. & Akassoglou, K. Breaking boundaries- coagulation and fibrinolysis at the neurovascular interface. Front. Cell. Neurosci. 9, 354 (2015).
    • (2015) Front. Cell. Neurosci. , vol.9 , pp. 354
    • Bardehle, S.1    Rafalski, V.A.2    Akassoglou, K.3
  • 234
    • 70449433875 scopus 로고    scopus 로고
    • Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
    • Zhong, Z. et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J. Clin. Invest. 119, 3437-3449 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 3437-3449
    • Zhong, Z.1
  • 235
    • 84909996967 scopus 로고    scopus 로고
    • α-Synuclein is transported into and out of the brain by the blood-brain barrier
    • Sui, Y.-T., Bullock, K. M., Erickson, M. A., Zhang, J. & Banks, W. A. α-Synuclein is transported into and out of the brain by the blood-brain barrier. Peptides 62, 197-202 (2014).
    • (2014) Peptides , vol.62 , pp. 197-202
    • Sui, Y.-T.1    Bullock, K.M.2    Erickson, M.A.3    Zhang, J.4    Banks, W.A.5
  • 236
    • 84934983329 scopus 로고    scopus 로고
    • α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
    • Peelaerts, W. et al. α-Synuclein strains cause distinct synucleinopathies after local and systemic administration. Nature 522, 340-344 (2015).
    • (2015) Nature , vol.522 , pp. 340-344
    • Peelaerts, W.1
  • 237
    • 85042660723 scopus 로고    scopus 로고
    • Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: Another mechanism for initiation and progression of Parkinson's disease?
    • Matsumoto, J. et al. Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease? Acta Neuropathol. Commun. 5, 71 (2017).
    • (2017) Acta Neuropathol. Commun. , vol.5 , pp. 71
    • Matsumoto, J.1
  • 238
    • 84917736593 scopus 로고    scopus 로고
    • Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease
    • Shi, M. et al. Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol. 128, 639-650 (2014).
    • (2014) Acta Neuropathol. , vol.128 , pp. 639-650
    • Shi, M.1
  • 239
    • 84914680221 scopus 로고    scopus 로고
    • Air pollution and children: Neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration
    • Calderón-Garcidueñas, L. et al. Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration. J. Alzheimers Dis. 43, 1039-1058 (2015).
    • (2015) J. Alzheimers Dis. , vol.43 , pp. 1039-1058
    • Calderón-Garcidueñas, L.1
  • 240
    • 84868573143 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier
    • Pardridge, W. M. Drug transport across the blood-brain barrier. J. Cereb. Blood Flow Metab. 32, 1959-1972 (2012).
    • (2012) J. Cereb. Blood Flow Metab. , vol.32 , pp. 1959-1972
    • Pardridge, W.M.1
  • 241
    • 84926095809 scopus 로고    scopus 로고
    • Biologics: Transferrin' bispecific antibodies across the blood-brain barrier
    • Bray, N. Biologics: Transferrin' bispecific antibodies across the blood-brain barrier. Nat. Rev. Drug Discov. 14, 14-15 (2015).
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 14-15
    • Bray, N.1
  • 242
    • 84891804917 scopus 로고    scopus 로고
    • Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
    • Niewoehner, J. et al. Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle. Neuron 81, 49-60 (2014).
    • (2014) Neuron , vol.81 , pp. 49-60
    • Niewoehner, J.1
  • 243
    • 84908884134 scopus 로고    scopus 로고
    • Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
    • Yu, Y. J. et al. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Sci. Transl Med. 6, 261ra154 (2014).
    • (2014) Sci. Transl Med. , vol.6 , pp. 261ra154
    • Yu, Y.J.1
  • 244
    • 84938527006 scopus 로고    scopus 로고
    • Systemically administered brain-targeted nanoparticles transport peptides across the blood-brain barrier and provide neuroprotection
    • Yemisci, M. et al. Systemically administered brain-targeted nanoparticles transport peptides across the blood-brain barrier and provide neuroprotection. J. Cereb. Blood Flow Metab. 35, 469-475 (2015).
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 469-475
    • Yemisci, M.1
  • 245
    • 84962755280 scopus 로고    scopus 로고
    • Microbubble-assisted ultrasound for drug delivery in the brain and central nervous system
    • Burgess, A. & Hynynen, K. Microbubble-assisted ultrasound for drug delivery in the brain and central nervous system. Adv. Exp. Med. Biol. 880, 293-308 (2016).
    • (2016) Adv. Exp. Med. Biol. , vol.880 , pp. 293-308
    • Burgess, A.1    Hynynen, K.2
  • 246
    • 84998981017 scopus 로고    scopus 로고
    • Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound
    • Poon, C., McMahon, D. & Hynynen, K. Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound. Neuropharmacology 120, 20-37 (2017).
    • (2017) Neuropharmacology , vol.120 , pp. 20-37
    • Poon, C.1    McMahon, D.2    Hynynen, K.3
  • 247
    • 0033850218 scopus 로고    scopus 로고
    • Mutational analysis of GLUT1 (SLC2A1) in Glut-1 deficiency syndrome
    • Wang, D., Kranz-Eble, P. & De Vivo, D. C. Mutational analysis of GLUT1 (SLC2A1) in Glut-1 deficiency syndrome. Hum. Mutat. 16, 224-231 (2000).
    • (2000) Hum. Mutat. , vol.16 , pp. 224-231
    • Wang, D.1    Kranz-Eble, P.2    De Vivo, D.C.3
  • 248
    • 84933064751 scopus 로고    scopus 로고
    • A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome
    • Alakbarzade, V. et al. A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome. Nat. Genet. 47, 814-817 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 814-817
    • Alakbarzade, V.1
  • 249
    • 84933040235 scopus 로고    scopus 로고
    • Inactivating mutations in MFSD2A, required for ω3 fatty acid transport in brain, cause a lethal microcephaly syndrome
    • Guemez-Gamboa, A. et al. Inactivating mutations in MFSD2A, required for ω3 fatty acid transport in brain, cause a lethal microcephaly syndrome. Nat. Genet. 47, 809-813 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 809-813
    • Guemez-Gamboa, A.1
  • 250
    • 85008144257 scopus 로고    scopus 로고
    • Clinical and molecular characteristics of SLC16A2 (MCT8) mutations in three families with the Allan-Herndon-Dudley syndrome
    • Novara, F. et al. Clinical and molecular characteristics of SLC16A2 (MCT8) mutations in three families with the Allan-Herndon-Dudley syndrome. Hum. Mutat. 38, 260-264 (2017).
    • (2017) Hum. Mutat. , vol.38 , pp. 260-264
    • Novara, F.1
  • 251
    • 85018740781 scopus 로고    scopus 로고
    • Band-like calcification with simplified gyration and polymicrogyria: Report of 10 new families and identification of five novel OCLN mutations
    • Abdel-Hamid, M. S., Abdel-Salam, G. M. H., Issa, M. Y., Emam, B. A. & Zaki, M. S. Band-like calcification with simplified gyration and polymicrogyria: report of 10 new families and identification of five novel OCLN mutations. J. Hum. Genet. 62, 553-559 (2017).
    • (2017) J. Hum. Genet. , vol.62 , pp. 553-559
    • Abdel-Hamid, M.S.1    Abdel-Salam, G.M.H.2    Issa, M.Y.3    Emam, B.A.4    Zaki, M.S.5
  • 252
    • 84873968168 scopus 로고    scopus 로고
    • Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts
    • Akawi, N. A. et al. Delineation of the clinical, molecular and cellular aspects of novel JAM3 mutations underlying the autosomal recessive hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Hum. Mutat. 34, 498-505 (2013).
    • (2013) Hum. Mutat. , vol.34 , pp. 498-505
    • Akawi, N.A.1
  • 253
    • 84883463387 scopus 로고    scopus 로고
    • Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
    • Keller, A. et al. Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nat. Genet. 45, 1077-1082 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1077-1082
    • Keller, A.1
  • 254
    • 84873693930 scopus 로고    scopus 로고
    • Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification
    • Nicolas, G. et al. Mutation of the PDGFRB gene as a cause of idiopathic basal ganglia calcification. Neurology 80, 181-187 (2013).
    • (2013) Neurology , vol.80 , pp. 181-187
    • Nicolas, G.1
  • 255
    • 85024387305 scopus 로고    scopus 로고
    • Linking amyloid-β and tau deposition in Alzheimer disease
    • Vemuri, P. & Schöll, M. Linking amyloid-β and tau deposition in Alzheimer disease. JAMA Neurol. 74, 766-768 (2017).
    • (2017) JAMA Neurol. , vol.74 , pp. 766-768
    • Vemuri, P.1    Schöll, M.2
  • 256
    • 84991383345 scopus 로고    scopus 로고
    • Analysis of the brain mural cell transcriptome
    • He, L. et al. Analysis of the brain mural cell transcriptome. Sci. Rep. 6, 35108 (2016).
    • (2016) Sci. Rep. , vol.6 , pp. 35108
    • He, L.1


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