Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Nature Communications

Volumn 6, Issue , 2015, Pages

  Ryu, Jae Kyu ^a   Petersen, Mark A ^a,b   Murray, Sara G ^a   Baeten, Kim M ^a   Meyer Franke, Anke ^a   Chan, Justin P ^a   Vagena, Eirini ^a   Bedard, Catherine ^a   Machado, Michael R ^a   Coronado, Pamela E Rios ^a   Prod'homme, Thomas ^a   Charo, Israel F ^a   Lassmann, Hans ^c   Degen, Jay L ^d   Zamvil, Scott S ^a   Akassoglou, Katerina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CD11B ANTIGEN; CD18 ANTIGEN; CHEMOKINE; FIBRINOGEN; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HIGH MOLECULAR WEIGHT KININOGEN; INTERLEUKIN 12P40; INTERLEUKIN 17F; INTERLEUKIN 4; LIPOCALIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; CCL2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE; CXCL10 PROTEIN, MOUSE; DNA BINDING PROTEIN; FIBRIN; HOMEODOMAIN PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; RAG-1 PROTEIN; RAG2 PROTEIN, MOUSE;

ANTIGEN; BLINDNESS; BLOOD; BRAIN; CELLS AND CELL COMPONENTS; COAGULATION; IMMUNE RESPONSE; IMMUNITY; INHIBITION; NEUROLOGY;

ADAPTIVE IMMUNITY; ADULT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS CALLOSUM; DEMYELINATION; FEMALE; FIBRINOGEN BLOOD LEVEL; GENE EXPRESSION; IN VIVO STUDY; LYMPHOCYTE ACTIVATION; MALE; MICROARRAY ANALYSIS; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN SECRETION; T LYMPHOCYTE ACTIVATION; TH1 CELL; UPREGULATION; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; CELL PROLIFERATION; DEMYELINATING DISEASE; DRUG EFFECTS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FLOW CYTOMETRY; GENE; GENE EXPRESSION PROFILING; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MICROGLIA; PATHOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD11B; AUTOIMMUNITY; BLOOD-BRAIN BARRIER; BRAIN; CELL PROLIFERATION; CHEMOKINE CCL2; CHEMOKINE CXCL10; CHEMOKINES; DEMYELINATING DISEASES; DNA-BINDING PROTEINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FIBRIN; FIBRINOGEN; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENES, MHC CLASS II; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MICE; MICE, KNOCKOUT; MICROGLIA; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; RATS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CHEMOKINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; TH1 CELLS;

EID: 84941578601     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9164     Document Type: Article

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