메뉴 건너뛰기




Volumn 20, Issue , 2018, Pages 95-118

Synthetic Biology: Immunotherapy by Design

Author keywords

autoimmune disease; cancer; cellular immunotherapy; genetic circuits; infectious disease; synthetic biology

Indexed keywords

BIOLOGY; T-CELLS;

EID: 85042474325     PISSN: 15239829     EISSN: 15454274     Source Type: Book Series    
DOI: 10.1146/annurev-bioeng-062117-121147     Document Type: Review
Times cited : (23)

References (150)
  • 1
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. 2012. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 12:252-64
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 2
    • 84943516465 scopus 로고    scopus 로고
    • Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
    • Van Allen EM, Miao D, Schilling B, Shukla SA, Blank C, et al. 2015. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 350:207-11
    • (2015) Science , vol.350 , pp. 207-211
    • Van Allen, E.M.1    Miao, D.2    Schilling, B.3    Shukla, S.A.4    Blank, C.5
  • 3
    • 84962301577 scopus 로고    scopus 로고
    • Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade
    • McGranahan N, Furness AJ, Rosenthal R, Ramskov S, Lyngaa R, et al. 2016. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science 351:1463-69
    • (2016) Science , vol.351 , pp. 1463-1469
    • McGranahan, N.1    Furness, A.J.2    Rosenthal, R.3    Ramskov, S.4    Lyngaa, R.5
  • 4
    • 84938963928 scopus 로고    scopus 로고
    • NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma
    • Rapoport AP, Stadtmauer EA, Binder-Scholl GK, Goloubeva O, Vogl DT, et al. 2015. NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma. Nat. Med. 21:914-21
    • (2015) Nat. Med. , vol.21 , pp. 914-921
    • Rapoport, A.P.1    Stadtmauer, E.A.2    Binder-Scholl, G.K.3    Goloubeva, O.4    Vogl, D.T.5
  • 5
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. 2013. The basic principles of chimeric antigen receptor design. Cancer Discov. 3:388-98
    • (2013) Cancer Discov. , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 6
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter DL, Levine BL, Kalos M, Bagg A, June CH. 2011. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N. Engl. J. Med. 365:725-33
    • (2011) N. Engl. J. Med. , vol.365 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 7
    • 84896335556 scopus 로고    scopus 로고
    • Efficacy and toxicitymanagement of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
    • Davila ML, Riviere I,Wang X, Bartido S, Park J, et al. 2014. Efficacy and toxicitymanagement of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci. Transl. Med. 6:224ra25
    • (2014) Sci. Transl. Med. , vol.6 , pp. 224ra25
    • Davila, M.L.1    Riviere, I.2    Wang, X.3    Bartido, S.4    Park, J.5
  • 8
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner TS, Cantor CR, Collins JJ. 2000. Construction of a genetic toggle switch in Escherichia coli. Nature 403:339-42
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 9
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz MB, Leibler S. 2000. A synthetic oscillatory network of transcriptional regulators. Nature 403:335-38
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 11
    • 85019107155 scopus 로고    scopus 로고
    • Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
    • Weinberg BH, Pham NTH, Caraballo LD, Lozanoski T, Engel A, et al. 2017. Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells. Nat. Biotechnol. 35:453-62
    • (2017) Nat. Biotechnol. , vol.35 , pp. 453-462
    • Weinberg, B.H.1    Pham, N.T.H.2    Caraballo, L.D.3    Lozanoski, T.4    Engel, A.5
  • 12
    • 84875230351 scopus 로고    scopus 로고
    • Synthetic circuits integrating logic and memory in living cells
    • Siuti P, Yazbek J, Lu TK. 2013. Synthetic circuits integrating logic and memory in living cells. Nat. Biotechnol. 31:448-52
    • (2013) Nat. Biotechnol. , vol.31 , pp. 448-452
    • Siuti, P.1    Yazbek, J.2    Lu, T.K.3
  • 13
    • 84902534508 scopus 로고    scopus 로고
    • Biological 2-input decoder circuit in human cells
    • Guinn M, Bleris L. 2014. Biological 2-input decoder circuit in human cells. ACS Synth. Biol. 3:627-33
    • (2014) ACS Synth. Biol. , vol.3 , pp. 627-633
    • Guinn, M.1    Bleris, L.2
  • 14
    • 84865135567 scopus 로고    scopus 로고
    • Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells
    • Wei P,Wong WW, Park JS, Corcoran EE, Peisajovich SG, et al. 2012. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature 488:384-88
    • (2012) Nature , vol.488 , pp. 384-388
    • Wei, P.1    Wong, W.W.2    Park, J.S.3    Corcoran, E.E.4    Peisajovich, S.G.5
  • 15
    • 0034212551 scopus 로고    scopus 로고
    • Engineering stability in gene networks by autoregulation
    • Becskei A, Serrano L. 2000. Engineering stability in gene networks by autoregulation. Nature 405:590-93
    • (2000) Nature , vol.405 , pp. 590-593
    • Becskei, A.1    Serrano, L.2
  • 16
    • 85002979388 scopus 로고    scopus 로고
    • Beta-cell-mimetic designer cells provide closed-loop glycemic control
    • Xie M, Ye H, Wang H, Charpin-El Hamri G, Lormeau C, et al. 2016. β-cell-mimetic designer cells provide closed-loop glycemic control. Science 354:1296-301
    • (2016) Science , vol.354 , pp. 1296-1301
    • Xie, M.1    Ye, H.2    Wang, H.3    Charpin-El Hamri, G.4    Lormeau, C.5
  • 17
    • 38049001166 scopus 로고    scopus 로고
    • Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
    • Atsumi S, Hanai T, Liao JC. 2008. Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels. Nature 451:86-89
    • (2008) Nature , vol.451 , pp. 86-89
    • Atsumi, S.1    Hanai, T.2    Liao, J.C.3
  • 18
    • 33645870422 scopus 로고    scopus 로고
    • Production of the antimalarial drug precursor artemisinic acid in engineered yeast
    • Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, et al. 2006. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940-43
    • (2006) Nature , vol.440 , pp. 940-943
    • Ro, D.K.1    Paradise, E.M.2    Ouellet, M.3    Fisher, K.J.4    Newman, K.L.5
  • 21
    • 77957329119 scopus 로고    scopus 로고
    • Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli
    • Ajikumar PK, Xiao WH, Tyo KE,Wang Y, Simeon F, et al. 2010. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science 330:70-74
    • (2010) Science , vol.330 , pp. 70-74
    • Ajikumar, P.K.1    Xiao, W.H.2    Tyo, K.E.3    Wang, Y.4    Simeon, F.5
  • 22
    • 79959374585 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol
    • YimH,Haselbeck R, NiuW, Pujol-BaxleyC, Burgard A, et al. 2011. Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol. Nat. Chem. Biol. 7:445-52
    • (2011) Nat. Chem. Biol. , vol.7 , pp. 445-452
    • Yim, H.1    Haselbeck, R.2    Niu, W.3    Pujol-Baxley, C.4    Burgard, A.5
  • 23
    • 84963516758 scopus 로고    scopus 로고
    • One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli
    • Choi SY, Park SJ, Kim WJ, Yang JE, Lee H, et al. 2016. One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli. Nat. Biotechnol. 34:435-40
    • (2016) Nat. Biotechnol. , vol.34 , pp. 435-440
    • Choi, S.Y.1    Park, S.J.2    Kim, W.J.3    Yang, J.E.4    Lee, H.5
  • 25
    • 84909963314 scopus 로고    scopus 로고
    • Toehold switches: De-novo-designed regulators of gene expression
    • Green AA, Silver PA, Collins JJ, Yin P. 2014. Toehold switches: de-novo-designed regulators of gene expression. Cell 159:925-39
    • (2014) Cell , vol.159 , pp. 925-939
    • Green, A.A.1    Silver, P.A.2    Collins, J.J.3    Yin, P.4
  • 27
    • 84864634066 scopus 로고    scopus 로고
    • A synthetic biology framework for programming eukaryotic transcription functions
    • Khalil AS, Lu TK, Bashor CJ, Ramirez CL, Pyenson NC, et al. 2012. A synthetic biology framework for programming eukaryotic transcription functions. Cell 150:647-58
    • (2012) Cell , vol.150 , pp. 647-658
    • Khalil, A.S.1    Lu, T.K.2    Bashor, C.J.3    Ramirez, C.L.4    Pyenson, N.C.5
  • 29
    • 84958230998 scopus 로고    scopus 로고
    • Engineering customized cell sensing and response behaviors using synthetic Notch receptors
    • Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, et al. 2016. Engineering customized cell sensing and response behaviors using synthetic Notch receptors. Cell 164:780-91
    • (2016) Cell , vol.164 , pp. 780-791
    • Morsut, L.1    Roybal, K.T.2    Xiong, X.3    Gordley, R.M.4    Coyle, S.M.5
  • 31
    • 79951997641 scopus 로고    scopus 로고
    • A modular cloning system for standardized assembly of multigene constructs
    • Weber E, Engler C, Gruetzner R, Werner S, Marillonnet S. 2011. A modular cloning system for standardized assembly of multigene constructs. PLOS ONE 6:e16765
    • (2011) PLOS ONE , vol.6 , pp. e16765
    • Weber, E.1    Engler, C.2    Gruetzner, R.3    Werner, S.4    Marillonnet, S.5
  • 33
    • 84879264708 scopus 로고    scopus 로고
    • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
    • GajT,Gersbach CA, BarbasCF 3rd. 2013. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering. Trends Biotechnol. 31:397-405
    • (2013) Trends Biotechnol. , vol.31 , pp. 397-405
    • Gaj, T.1    Gersbach, C.A.2    Barbas, C.F.3
  • 34
    • 85010188952 scopus 로고    scopus 로고
    • Cell-based therapeutics: Making a Faustian pact with biology
    • Woodsworth DJ, Holt RA. 2017. Cell-based therapeutics: making a Faustian pact with biology. Trends Mol. Med. 23:104-15
    • (2017) Trends Mol. Med. , vol.23 , pp. 104-115
    • Woodsworth, D.J.1    Holt, R.A.2
  • 36
    • 0024166189 scopus 로고
    • Use of tumorinfiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma A preliminary report
    • Rosenberg SA, Packard BS, Aebersold PM, Solomon D, Topalian SL, et al. 1988. Use of tumorinfiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report. N. Engl. J. Med. 319:1676-80
    • (1988) N. Engl. J. Med. , vol.319 , pp. 1676-1680
    • Rosenberg, S.A.1    Packard, B.S.2    Aebersold, P.M.3    Solomon, D.4    Topalian, S.L.5
  • 37
    • 33750699642 scopus 로고    scopus 로고
    • A phase i study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
    • Kershaw MH, Westwood JA, Parker LL, Wang G, Eshhar Z, et al. 2006. A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer. Clin. Cancer Res. 12:6106-15
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6106-6115
    • Kershaw, M.H.1    Westwood, J.A.2    Parker, L.L.3    Wang, G.4    Eshhar, Z.5
  • 38
    • 33845294816 scopus 로고    scopus 로고
    • CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells
    • Kowolik CM, Topp MS, Gonzalez S, Pfeiffer T, Olivares S, et al. 2006. CD28 costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of adoptively transferred T cells. Cancer Res. 66:10995-1004
    • (2006) Cancer Res. , vol.66 , pp. 10995-11004
    • Kowolik, C.M.1    Topp, M.S.2    Gonzalez, S.3    Pfeiffer, T.4    Olivares, S.5
  • 39
    • 34548485103 scopus 로고    scopus 로고
    • Optimizing adoptive polyclonalTcell immunotherapy of lymphomas, using a chimericTcell receptor possessing CD28 andCD137 costimulatory domains
    • Wang J, Jensen M, Lin Y, Sui X, Chen E, et al. 2007. Optimizing adoptive polyclonalTcell immunotherapy of lymphomas, using a chimericTcell receptor possessing CD28 andCD137 costimulatory domains. Hum. Gene Ther. 18:712-25
    • (2007) Hum. Gene Ther. , vol.18 , pp. 712-725
    • Wang, J.1    Jensen, M.2    Lin, Y.3    Sui, X.4    Chen, E.5
  • 40
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • Kochenderfer JN, Dudley ME, Feldman SA, Wilson WH, Spaner DE, et al. 2012. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood 119:2709-20
    • (2012) Blood , vol.119 , pp. 2709-2720
    • Kochenderfer, J.N.1    Dudley, M.E.2    Feldman, S.A.3    Wilson, W.H.4    Spaner, D.E.5
  • 41
    • 77950480974 scopus 로고    scopus 로고
    • Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: Case report of an unforeseen adverse event in a phase i clinical trial
    • Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M. 2010. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial. Mol. Ther. 18:666-68
    • (2010) Mol. Ther. , vol.18 , pp. 666-668
    • Brentjens, R.1    Yeh, R.2    Bernal, Y.3    Riviere, I.4    Sadelain, M.5
  • 42
    • 85019723531 scopus 로고    scopus 로고
    • Therapeutic T cell engineering
    • Sadelain M, Riviere I, Riddell S. 2017. Therapeutic T cell engineering. Nature 545:423-31
    • (2017) Nature , vol.545 , pp. 423-431
    • Sadelain, M.1    Riviere, I.2    Riddell, S.3
  • 43
    • 85012023606 scopus 로고    scopus 로고
    • The principles of engineering immune cells to treat cancer
    • LimWA, June CH. 2017. The principles of engineering immune cells to treat cancer. Cell 168:724-40
    • (2017) Cell , vol.168 , pp. 724-740
    • Lim, W.A.1    June, C.H.2
  • 44
    • 0028079896 scopus 로고
    • Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors
    • RobertsMR, Qin L, Zhang D, Smith DH, Tran AC, et al. 1994. Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors. Blood 84:2878-89
    • (1994) Blood , vol.84 , pp. 2878-2889
    • Roberts, M.R.1    Qin, L.2    Zhang, D.3    Smith, D.H.4    Tran, A.C.5
  • 45
    • 0035989039 scopus 로고    scopus 로고
    • A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy
    • Deeks SG, Wagner B, Anton PA, Mitsuyasu RT, Scadden DT, et al. 2002. A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Mol. Ther. 5:788-97
    • (2002) Mol. Ther. , vol.5 , pp. 788-797
    • Deeks, S.G.1    Wagner, B.2    Anton, P.A.3    Mitsuyasu, R.T.4    Scadden, D.T.5
  • 46
    • 84860718270 scopus 로고    scopus 로고
    • Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells
    • Scholler J, Brady TL, Binder-Scholl G, Hwang WT, Plesa G, et al. 2012. Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells. Sci. Transl. Med. 4:132ra53
    • (2012) Sci. Transl. Med. , vol.4 , pp. 132ra53
    • Scholler, J.1    Brady, T.L.2    Binder-Scholl, G.3    Hwang, W.T.4    Plesa, G.5
  • 47
    • 84993996143 scopus 로고    scopus 로고
    • Chimeric antigen receptor T cells guided by the single-chain Fv of a broadly neutralizing antibody specifically and effectively eradicate virus reactivated from latency in CD4+ T lymphocytes isolated from HIV-1-infected individuals receiving suppressive combined antiretroviral therapy
    • Liu B, Zou F, Lu L, Chen C, He D, et al. 2016. Chimeric antigen receptor T cells guided by the single-chain Fv of a broadly neutralizing antibody specifically and effectively eradicate virus reactivated from latency in CD4+ T lymphocytes isolated from HIV-1-infected individuals receiving suppressive combined antiretroviral therapy. J. Virol. 90:9712-24
    • (2016) J. Virol. , vol.90 , pp. 9712-9724
    • Liu, B.1    Zou, F.2    Lu, L.3    Chen, C.4    He, D.5
  • 48
    • 84982868474 scopus 로고    scopus 로고
    • HIV-1-specific chimeric antigen receptors based on broadly neutralizing antibodies
    • AliA, Kitchen SG,Chen IS,NgHL,Zack JA, Yang OO.2016. HIV-1-specific chimeric antigen receptors based on broadly neutralizing antibodies. J. Virol. 90:6999-7006
    • (2016) J. Virol. , vol.90 , pp. 6999-7006
    • Ali, A.1    Kitchen, S.G.2    Chen, I.S.3    Ng, H.L.4    Zack, J.A.5    Yang, O.O.6
  • 49
    • 85016249693 scopus 로고    scopus 로고
    • Engineering HIV-resistant, anti-HIV chimeric antigen receptor T cells
    • Hale M, Mesojednik T, Romano Ibarra GS, Sahni J, Bernard A, et al. 2017. Engineering HIV-resistant, anti-HIV chimeric antigen receptor T cells. Mol. Ther. 25:570-79
    • (2017) Mol. Ther. , vol.25 , pp. 570-579
    • Hale, M.1    Mesojednik, T.2    Romanobarra, G.S.3    Sahni, J.4    Bernard, A.5
  • 50
    • 85016136898 scopus 로고    scopus 로고
    • CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses
    • Descours B, Petitjean G, L opez-Zaragoza JL, Bruel T, Raffel R, et al. 2017. CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses. Nature 543:564-67
    • (2017) Nature , vol.543 , pp. 564-567
    • Descours, B.1    Petitjean, G.2    Opez-Zaragoza, J.L.L.3    Bruel, T.4    Raffel, R.5
  • 51
    • 79958072618 scopus 로고    scopus 로고
    • Epidemiology and treatment approaches in management of invasive fungal infections
    • Kriengkauykiat J, Ito JI, Dadwal SS. 2011. Epidemiology and treatment approaches in management of invasive fungal infections. Clin. Epidemiol. 3:175-91
    • (2011) Clin. Epidemiol. , vol.3 , pp. 175-191
    • Kriengkauykiat, J.1    Ito, J.I.2    Dadwal, S.S.3
  • 53
    • 77954930278 scopus 로고    scopus 로고
    • Exogenous interferon-γ immunotherapy for invasive fungal infections in kidney transplant patients
    • Armstrong-James D, Teo IA, Shrivastava S, Petrou MA, Taube D, et al. 2010. Exogenous interferon-γ immunotherapy for invasive fungal infections in kidney transplant patients. Am. J. Transplant. 10:1796-803
    • (2010) Am. J. Transplant. , vol.10 , pp. 1796-1803
    • Armstrong-James, D.1    Teo, I.A.2    Shrivastava, S.3    Petrou, M.A.4    Taube, D.5
  • 54
    • 13444263255 scopus 로고    scopus 로고
    • The safety of interferon-γ-1b therapy for invasive fungal infections after hematopoietic stem cell transplantation
    • Safdar A, RodriguezG,OhmagariN,KontoyiannisDP, Rolston KV, et al. 2005. The safety of interferon-γ-1b therapy for invasive fungal infections after hematopoietic stem cell transplantation. Cancer 103:731-39
    • (2005) Cancer , vol.103 , pp. 731-739
    • Safdar, A.1    Rodriguez, G.2    Ohmagari, N.3    Kontoyiannis, D.P.4    Rolston, K.V.5
  • 55
    • 84861529161 scopus 로고    scopus 로고
    • Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: A randomized controlled trial
    • Jarvis JN, Meintjes G, Rebe K, Williams GN, Bicanic T, et al. 2012. Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial. AIDS 26:1105-13
    • (2012) AIDS , vol.26 , pp. 1105-1113
    • Jarvis, J.N.1    Meintjes, G.2    Rebe, K.3    Williams, G.N.4    Bicanic, T.5
  • 56
    • 62449104891 scopus 로고    scopus 로고
    • Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
    • Cowen LE, Singh SD, Kohler JR, Collins C, Zaas AK, et al. 2009. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. PNAS 106:2818-23
    • (2009) PNAS , vol.106 , pp. 2818-2823
    • Cowen, L.E.1    Singh, S.D.2    Kohler, J.R.3    Collins, C.4    Zaas, A.K.5
  • 57
    • 77954690760 scopus 로고    scopus 로고
    • Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection
    • Bryan RA, Jiang Z, Howell RC, Morgenstern A, Bruchertseifer F, et al. 2010. Radioimmunotherapy is more effective than antifungal treatment in experimental cryptococcal infection. J. Infect.Dis. 202:633-37
    • (2010) J. Infect.Dis. , vol.202 , pp. 633-637
    • Bryan, R.A.1    Jiang, Z.2    Howell, R.C.3    Morgenstern, A.4    Bruchertseifer, F.5
  • 58
    • 79959256586 scopus 로고    scopus 로고
    • Dose range evaluation of Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, in combination with amphotericin B-desoxycholate for treatment of murine systemic candidiasis
    • Louie A, Stein DS, Zack JZ, Liu W, Conde H, et al. 2011. Dose range evaluation of Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, in combination with amphotericin B-desoxycholate for treatment of murine systemic candidiasis. Antimicrob. Agents Chemother. 55:3295-304
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 3295-3304
    • Louie, A.1    Stein, D.S.2    Zack, J.Z.3    Liu, W.4    Conde, H.5
  • 59
    • 0242578106 scopus 로고    scopus 로고
    • A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation
    • Bozza S, Perruccio K, Montagnoli C, Gaziano R, Bellocchio S, et al. 2003. A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Blood 102:3807-14
    • (2003) Blood , vol.102 , pp. 3807-3814
    • Bozza, S.1    Perruccio, K.2    Montagnoli, C.3    Gaziano, R.4    Bellocchio, S.5
  • 60
    • 78650761670 scopus 로고    scopus 로고
    • Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era-experience from an adult haematology unit in Singapore
    • Ang AL, Linn YC. 2011. Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era-experience from an adult haematology unit in Singapore. Transfus. Med. 21:13-24
    • (2011) Transfus. Med. , vol.21 , pp. 13-24
    • Ang, A.L.1    Linn, Y.C.2
  • 61
    • 10044288445 scopus 로고    scopus 로고
    • Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: Retrospective case-control analysis of 491 episodes of Candida species bloodstream infections
    • Safdar A, Hanna HA, Boktour M, Kontoyiannis DP, Hachem R, et al. 2004. Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: retrospective case-control analysis of 491 episodes of Candida species bloodstream infections. Cancer 101:2859-65
    • (2004) Cancer , vol.101 , pp. 2859-2865
    • Safdar, A.1    Hanna, H.A.2    Boktour, M.3    Kontoyiannis, D.P.4    Hachem, R.5
  • 62
    • 77951912884 scopus 로고    scopus 로고
    • Safety and efficacy of activated transfected killer cells for neutropenic fungal infections
    • Lin L, Ibrahim AS, Baquir B, Fu Y, ApplebaumD, et al. 2010. Safety and efficacy of activated transfected killer cells for neutropenic fungal infections. J. Infect. Dis. 201:1708-17
    • (2010) J. Infect. Dis. , vol.201 , pp. 1708-1717
    • Lin, L.1    Ibrahim, A.S.2    Baquir, B.3    Fu, Y.4    Applebaum, D.5
  • 63
    • 28844459420 scopus 로고    scopus 로고
    • Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation
    • Perruccio K, Tosti A, Burchielli E, Topini F, Ruggeri L, et al. 2005. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 106:4397-406
    • (2005) Blood , vol.106 , pp. 4397-4406
    • Perruccio, K.1    Tosti, A.2    Burchielli, E.3    Topini, F.4    Ruggeri, L.5
  • 64
    • 84866504313 scopus 로고    scopus 로고
    • Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus
    • Gaundar SS, Clancy L, Blyth E, Meyer W, Gottlieb DJ. 2012. Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus. Cytotherapy 14:1119-30
    • (2012) Cytotherapy , vol.14 , pp. 1119-1130
    • Gaundar, S.S.1    Clancy, L.2    Blyth, E.3    Meyer, W.4    Gottlieb, D.J.5
  • 65
    • 84940886063 scopus 로고    scopus 로고
    • Clinicalscale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer
    • Bacher P, Jochheim-Richter A,Mockel-TenbrinkN, Kniemeyer O, Wingenfeld E, et al. 2015. Clinicalscale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer. Cytotherapy 17:1396-405
    • (2015) Cytotherapy , vol.17 , pp. 1396-1405
    • Bacher, P.1    Jochheim-Richter, A.2    Mockel-Tenbrink, N.3    Kniemeyer, O.4    Wingenfeld, E.5
  • 66
    • 84957427380 scopus 로고    scopus 로고
    • Adoptive transfer of Aspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: Progress and challenges
    • Papadopoulou A, Kaloyannidis P, Yannaki E, Cruz CR. 2016. Adoptive transfer of Aspergillus-specific T cells as a novel anti-fungal therapy for hematopoietic stem cell transplant recipients: progress and challenges. Crit. Rev. Oncol. Hematol. 98:62-72
    • (2016) Crit. Rev. Oncol. Hematol. , vol.98 , pp. 62-72
    • Papadopoulou, A.1    Kaloyannidis, P.2    Yannaki, E.3    Cruz, C.R.4
  • 67
    • 84904632405 scopus 로고    scopus 로고
    • Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection
    • Kumaresan PR, Manuri PR, Albert ND, Maiti S, Singh H, et al. 2014. Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection. PNAS 111:10660-65
    • (2014) PNAS , vol.111 , pp. 10660-10665
    • Kumaresan, P.R.1    Manuri, P.R.2    Albert, N.D.3    Maiti, S.4    Singh, H.5
  • 71
    • 84976904277 scopus 로고    scopus 로고
    • Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease
    • Ellebrecht CT, Bhoj VG, Nace A, Choi EJ, Mao X, et al. 2016. Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353:179-84
    • (2016) Science , vol.353 , pp. 179-184
    • Ellebrecht, C.T.1    Bhoj, V.G.2    Nace, A.3    Choi, E.J.4    Mao, X.5
  • 72
    • 65249120858 scopus 로고    scopus 로고
    • Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor
    • Elinav E, Adam N, Waks T, Eshhar Z. 2009. Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor. Gastroenterology 136:1721-31
    • (2009) Gastroenterology , vol.136 , pp. 1721-1731
    • Elinav, E.1    Adam, N.2    Waks, T.3    Eshhar, Z.4
  • 73
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor PA, Lees CJ, Blazar BR. 2002. The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99:3493-99
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 75
    • 85027257022 scopus 로고    scopus 로고
    • HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells
    • Gornalusse GG, Hirata RK, Funk SE, Riolobos L, Lopes VS, et al. 2017. HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells. Nat. Biotechnol. 35:765-72
    • (2017) Nat. Biotechnol. , vol.35 , pp. 765-772
    • Gornalusse, G.G.1    Hirata, R.K.2    Funk, S.E.3    Riolobos, L.4    Lopes, V.S.5
  • 76
    • 84923313146 scopus 로고    scopus 로고
    • Engineered antigen-specific human regulatory T cells: Immunosuppression of FVIII-specific T-and B-cell responses
    • KimYC,Zhang AH, SuY,Rieder SA, Rossi RJ, et al. 2015. Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T-and B-cell responses. Blood 125:1107-15
    • (2015) Blood , vol.125 , pp. 1107-1115
    • Kim, Y.C.1    Zhang, A.H.2    Su, Y.3    Rieder, S.A.4    Rossi, R.J.5
  • 77
    • 85018027174 scopus 로고    scopus 로고
    • FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T-and B-cell responses to FVIII
    • Yoon J, Schmidt A, Zhang AH, Konigs C, Kim YC, Scott DW. 2017. FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T-and B-cell responses to FVIII. Blood 129:238-45
    • (2017) Blood , vol.129 , pp. 238-245
    • Yoon, J.1    Schmidt, A.2    Zhang, A.H.3    Konigs, C.4    Kim, Y.C.5    Scott, D.W.6
  • 79
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. 2010. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol. Ther. 18:843-51
    • (2010) Mol. Ther. , vol.18 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3    Dudley, M.E.4    Laurencot, C.M.5    Rosenberg, S.A.6
  • 80
    • 84923019006 scopus 로고    scopus 로고
    • T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial
    • Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, et al. 2015. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet 385:517-28
    • (2015) Lancet , vol.385 , pp. 517-528
    • Lee, D.W.1    Kochenderfer, J.N.2    Stetler-Stevenson, M.3    Cui, Y.K.4    Delbrook, C.5
  • 81
    • 84873991752 scopus 로고    scopus 로고
    • Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy
    • Morgan RA, Chinnasamy N, Abate-Daga D, Gros A, Robbins PF, et al. 2013. Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. J. Immunother. 36:133-51
    • (2013) J. Immunother. , vol.36 , pp. 133-151
    • Morgan, R.A.1    Chinnasamy, N.2    Abate-Daga, D.3    Gros, A.4    Robbins, P.F.5
  • 82
    • 84990240811 scopus 로고    scopus 로고
    • Adoptive T-cell therapy for fungal infections in haematology patients
    • Deo SS, Gottlieb DJ. 2015. Adoptive T-cell therapy for fungal infections in haematology patients. Clin. Transl. Immunol. 4:e40
    • (2015) Clin. Transl. Immunol. , vol.4 , pp. e40
    • Deo, S.S.1    Gottlieb, D.J.2
  • 83
    • 84930896988 scopus 로고    scopus 로고
    • Novel CD4-based bispecific chimeric antigen receptor designed for enhanced anti-HIV potency and absence of HIV entry receptor activity
    • Liu L, Patel B, Ghanem MH, Bundoc V, Zheng Z, et al. 2015. Novel CD4-based bispecific chimeric antigen receptor designed for enhanced anti-HIV potency and absence of HIV entry receptor activity. J. Virol. 89:6685-94
    • (2015) J. Virol. , vol.89 , pp. 6685-6694
    • Liu, L.1    Patel, B.2    Ghanem, M.H.3    Bundoc, V.4    Zheng, Z.5
  • 84
    • 82655181317 scopus 로고    scopus 로고
    • Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation
    • Delfortrie S, Pinte S, Mattot V, Samson C, Villain G, et al. 2011. Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation. Cancer Res. 71:7176-86
    • (2011) Cancer Res. , vol.71 , pp. 7176-7186
    • Delfortrie, S.1    Pinte, S.2    Mattot, V.3    Samson, C.4    Villain, G.5
  • 85
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3 enhancer
    • Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. 1994. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3 enhancer. PNAS 91:6496-500
    • (1994) PNAS , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 86
    • 33748357735 scopus 로고    scopus 로고
    • A2A adenosine receptor protects tumors from antitumor T cells
    • Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, et al. 2006. A2A adenosine receptor protects tumors from antitumor T cells. PNAS 103:13132-37
    • (2006) PNAS , vol.103 , pp. 13132-13137
    • Ohta, A.1    Gorelik, E.2    Prasad, S.J.3    Ronchese, F.4    Lukashev, D.5
  • 88
    • 84997766028 scopus 로고    scopus 로고
    • The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
    • Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, et al. 2016. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Immunity 45:374-88
    • (2016) Immunity , vol.45 , pp. 374-388
    • Scharping, N.E.1    Menk, A.V.2    Moreci, R.S.3    Whetstone, R.D.4    Dadey, R.E.5
  • 89
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM,Werb Z. 2002. Inflammation and cancer. Nature 420:860-67
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 90
    • 66349099293 scopus 로고    scopus 로고
    • Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated
    • Torroella-Kouri M, Silvera R, Rodriguez D, Caso R, Shatry A, et al. 2009. Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Res. 69:4800-9
    • (2009) Cancer Res. , vol.69 , pp. 4800-4809
    • Torroella-Kouri, M.1    Silvera, R.2    Rodriguez, D.3    Caso, R.4    Shatry, A.5
  • 91
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, et al. 2011. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1:54-67
    • (2011) Cancer Discov. , vol.1 , pp. 54-67
    • DeNardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3    Ruffell, B.4    Shiao, S.L.5
  • 92
    • 85016568668 scopus 로고    scopus 로고
    • Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer
    • Chen X, Takemoto Y, Deng H, Middelhoff M, Friedman RA, et al. 2017. Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer. Oncoimmunology 6:e1290034
    • (2017) Oncoimmunology , vol.6 , pp. e1290034
    • Chen, X.1    Takemoto, Y.2    Deng, H.3    Middelhoff, M.4    Friedman, R.A.5
  • 93
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, et al. 2006. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J. Clin. Oncol. 24:5373-80
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5373-5380
    • Bates, G.J.1    Fox, S.B.2    Han, C.3    Leek, R.D.4    Garcia, J.F.5
  • 94
    • 85006208770 scopus 로고    scopus 로고
    • Clinical manufacturing of CAR T cells: Foundation of a promising therapy
    • Wang X, Riviere I. 2016. Clinical manufacturing of CAR T cells: foundation of a promising therapy. Mol. Ther. Oncolytics 3:16015
    • (2016) Mol. Ther. Oncolytics , vol.3 , pp. 16015
    • Wang, X.1    Riviere, I.2
  • 95
    • 84894534641 scopus 로고    scopus 로고
    • Synthetic biology in mammalian cells: Next generation research tools and therapeutics
    • Lienert F, Lohmueller JJ, Garg A, Silver PA. 2014. Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nat. Rev. Mol. Cell Biol. 15:95-107
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 95-107
    • Lienert, F.1    Lohmueller, J.J.2    Garg, A.3    Silver, P.A.4
  • 97
    • 77952503333 scopus 로고    scopus 로고
    • Logic integration of mRNA signals by an RNAi-based molecular computer
    • Xie Z, Liu SJ, Bleris L, Benenson Y. 2010. Logic integration of mRNA signals by an RNAi-based molecular computer. Nucleic Acids Res. 38:2692-701
    • (2010) Nucleic Acids Res. , vol.38 , pp. 2692-2701
    • Xie, Z.1    Liu, S.J.2    Bleris, L.3    Benenson, Y.4
  • 98
    • 73349085934 scopus 로고    scopus 로고
    • An auxin-based degron system for the rapid depletion of proteins in nonplant cells
    • NishimuraK, FukagawaT,TakisawaH, KakimotoT, KanemakiM. 2009. An auxin-based degron system for the rapid depletion of proteins in nonplant cells. Nat. Methods 6:917-22
    • (2009) Nat. Methods , vol.6 , pp. 917-922
    • Nishimura, K.1    Fukagawa, T.2    Takisawa, H.3    Kakimoto, T.4    Kanemaki, M.5
  • 99
    • 84939497376 scopus 로고    scopus 로고
    • Tunable and reversible drug control of protein production via a self-excising degron
    • Chung HK, Jacobs CL, Huo Y, Yang J, Krumm SA, et al. 2015. Tunable and reversible drug control of protein production via a self-excising degron. Nat. Chem. Biol. 11:713-20
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 713-720
    • Chung, H.K.1    Jacobs, C.L.2    Huo, Y.3    Yang, J.4    Krumm, S.A.5
  • 101
    • 84945217637 scopus 로고    scopus 로고
    • Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
    • Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. 2015. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science 350:aab4077
    • (2015) Science , vol.350 , pp. aab4077
    • Wu, C.Y.1    Roybal, K.T.2    Puchner, E.M.3    Onuffer, J.4    Lim, W.A.5
  • 102
    • 84862815933 scopus 로고    scopus 로고
    • Rapid and orthogonal logic gating with a gibberellin-induced dimerization system
    • Miyamoto T, DeRose R, Suarez A, Ueno T, Chen M, et al. 2012. Rapid and orthogonal logic gating with a gibberellin-induced dimerization system. Nat. Chem. Biol. 8:465-70
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 465-470
    • Miyamoto, T.1    DeRose, R.2    Suarez, A.3    Ueno, T.4    Chen, M.5
  • 104
    • 21444442055 scopus 로고    scopus 로고
    • An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways
    • Inoue T, Heo WD, Grimley JS, Wandless TJ, Meyer T. 2005. An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat. Methods 2:415-18
    • (2005) Nat. Methods , vol.2 , pp. 415-418
    • Inoue, T.1    Heo, W.D.2    Grimley, J.S.3    Wandless, T.J.4    Meyer, T.5
  • 105
    • 70350070364 scopus 로고    scopus 로고
    • Spatiotemporal control of cell signalling using a light-switchable protein interaction
    • Levskaya A, Weiner OD, Lim WA, Voigt CA. 2009. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature 461:997-1001
    • (2009) Nature , vol.461 , pp. 997-1001
    • Levskaya, A.1    Weiner, O.D.2    Lim, W.A.3    Voigt, C.A.4
  • 106
    • 84925534357 scopus 로고    scopus 로고
    • A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
    • Polstein LR, Gersbach CA. 2015. A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat. Chem. Biol. 11:198-200
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 198-200
    • Polstein, L.R.1    Gersbach, C.A.2
  • 107
    • 84904480201 scopus 로고    scopus 로고
    • Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells
    • Niopek D, Benzinger D, Roensch J, Draebing T, Wehler P, et al. 2014. Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells. Nat. Commun. 5:4404
    • (2014) Nat. Commun. , vol.5 , pp. 4404
    • Niopek, D.1    Benzinger, D.2    Roensch, J.3    Draebing, T.4    Wehler, P.5
  • 108
    • 84920409500 scopus 로고    scopus 로고
    • Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins
    • Guntas G, Hallett RA, Zimmerman SP, Williams T, Yumerefendi H, et al. 2015. Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins. PNAS 112:112-17
    • (2015) PNAS , vol.112 , pp. 112-117
    • Guntas, G.1    Hallett, R.A.2    Zimmerman, S.P.3    Williams, T.4    Yumerefendi, H.5
  • 109
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracyclineresponsive promoters
    • Gossen M, Bujard H. 1992. Tight control of gene expression in mammalian cells by tetracyclineresponsive promoters. PNAS 89:5547-51
    • (1992) PNAS , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 110
    • 0023645007 scopus 로고
    • Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells
    • Brown M, Figge J, Hansen U, Wright C, Jeang KT, et al. 1987. lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell 49:603-12
    • (1987) Cell , vol.49 , pp. 603-612
    • Brown, M.1    Figge, J.2    Hansen, U.3    Wright, C.4    Jeang, K.T.5
  • 111
    • 47349097567 scopus 로고    scopus 로고
    • Rapid "opensource" engineering of customized zinc-finger nucleases for highly efficient gene modification
    • Maeder ML, Thibodeau-Beganny S, Osiak A, Wright DA, Anthony RM, et al. 2008. Rapid "opensource" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol. Cell 31:294-301
    • (2008) Mol. Cell , vol.31 , pp. 294-301
    • Maeder, M.L.1    Thibodeau-Beganny, S.2    Osiak, A.3    Wright, D.A.4    Anthony, R.M.5
  • 112
    • 84903942172 scopus 로고    scopus 로고
    • Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation
    • Keung AJ, Bashor CJ, Kiriakov S, Collins JJ, Khalil AS. 2014. Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation. Cell 158:110-20
    • (2014) Cell , vol.158 , pp. 110-120
    • Keung, A.J.1    Bashor, C.J.2    Kiriakov, S.3    Collins, J.J.4    Khalil, A.S.5
  • 113
    • 78650739853 scopus 로고    scopus 로고
    • Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors
    • Morbitzer R, Romer P, Boch J, Lahaye T. 2010. Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors. PNAS 107:21617-22
    • (2010) PNAS , vol.107 , pp. 21617-21622
    • Morbitzer, R.1    Romer, P.2    Boch, J.3    Lahaye, T.4
  • 115
    • 84873493550 scopus 로고    scopus 로고
    • Engineering designer transcription activator-like effector nucleases (TALENs) by REAL or REAL-Fast assembly
    • Reyon D, Khayter C, Regan MR, Joung JK, Sander JD. 2012. Engineering designer transcription activator-like effector nucleases (TALENs) by REAL or REAL-Fast assembly. Curr. Protoc. Mol. Biol. 100:12.15.1-12.15.14
    • (2012) Curr. Protoc. Mol. Biol. , vol.100 , pp. 12151-121514
    • Reyon, D.1    Khayter, C.2    Regan, M.R.3    Joung, J.K.4    Sander, J.D.5
  • 116
    • 84874687019 scopus 로고    scopus 로고
    • Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    • Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, et al. 2013. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152:1173-83
    • (2013) Cell , vol.152 , pp. 1173-1183
    • Qi, L.S.1    Larson, M.H.2    Gilbert, L.A.3    Doudna, J.A.4    Weissman, J.S.5
  • 120
    • 0037510038 scopus 로고    scopus 로고
    • Enhancing gene targeting with designed zinc finger nucleases
    • Bibikova M, Beumer K, Trautman JK, Carroll D. 2003. Enhancing gene targeting with designed zinc finger nucleases. Science 300:764
    • (2003) Science , vol.300 , pp. 764
    • Bibikova, M.1    Beumer, K.2    Trautman, J.K.3    Carroll, D.4
  • 121
  • 123
    • 38349092683 scopus 로고    scopus 로고
    • The genetic design of signaling cascades to record receptor activation
    • Barnea G, Strapps W, Herrada G, Berman Y, Ong J, et al. 2008. The genetic design of signaling cascades to record receptor activation. PNAS 105:64-69
    • (2008) PNAS , vol.105 , pp. 64-69
    • Barnea, G.1    Strapps, W.2    Herrada, G.3    Berman, Y.4    Ong, J.5
  • 124
    • 84990855364 scopus 로고    scopus 로고
    • EngineeringTcells with customized therapeutic response programs using synthetic Notch receptors
    • Roybal KT,Williams JZ, Morsut L, Rupp LJ, Kolinko I, et al. 2016. EngineeringTcells with customized therapeutic response programs using synthetic Notch receptors. Cell 167:419-32
    • (2016) Cell , vol.167 , pp. 419-432
    • Roybal, K.T.1    Williams, J.Z.2    Morsut, L.3    Rupp, L.J.4    Kolinko, I.5
  • 125
    • 84958214384 scopus 로고    scopus 로고
    • Precision tumor recognition by T cells with combinatorial antigen-sensing circuits
    • Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, et al. 2016. Precision tumor recognition by T cells with combinatorial antigen-sensing circuits. Cell 164:770-79
    • (2016) Cell , vol.164 , pp. 770-779
    • Roybal, K.T.1    Rupp, L.J.2    Morsut, L.3    Walker, W.J.4    McNally, K.A.5
  • 126
    • 84887471195 scopus 로고    scopus 로고
    • Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma
    • Hegde M, Corder A, Chow KK, Mukherjee M, Ashoori A, et al. 2013. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma. Mol. Ther. 21:2087-101
    • (2013) Mol. Ther. , vol.21 , pp. 2087-2101
    • Hegde, M.1    Corder, A.2    Chow, K.K.3    Mukherjee, M.4    Ashoori, A.5
  • 127
    • 84880259439 scopus 로고    scopus 로고
    • TanCAR: A novel bispecific chimeric antigen receptor for cancer immunotherapy
    • Grada Z, Hegde M, Byrd T, Shaffer DR, Ghazi A, et al. 2013. TanCAR: a novel bispecific chimeric antigen receptor for cancer immunotherapy. Mol. Ther. Nucleic Acids 2:e105
    • (2013) Mol. Ther. Nucleic Acids , vol.2 , pp. e105
    • Grada, Z.1    Hegde, M.2    Byrd, T.3    Shaffer, D.R.4    Ghazi, A.5
  • 129
    • 84955503891 scopus 로고    scopus 로고
    • Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies
    • RodgersDT, MazagovaM,Hampton EN, Cao Y, RamadossNS, et al. 2016. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies. PNAS 113:E459-68
    • (2016) PNAS , vol.113 , pp. E459-E468
    • Rodgers, D.T.1    Mazagova, M.2    Hampton, E.N.3    Cao, Y.4    Ramadoss, N.S.5
  • 130
    • 84955502256 scopus 로고    scopus 로고
    • Versatile strategy for controlling the specificity and activity of engineered T cells
    • MaJS, Kim JY, Kazane SA, Choi SH, Yun HY, et al. 2016. Versatile strategy for controlling the specificity and activity of engineered T cells. PNAS 113:E450-58
    • (2016) PNAS , vol.113 , pp. E450-E458
    • Ma, J.S.1    Kim, J.Y.2    Kazane, S.A.3    Choi, S.H.4    Yun, H.Y.5
  • 131
    • 84870309981 scopus 로고    scopus 로고
    • Redirecting gene-modified T cells toward various cancer types using tagged antibodies
    • Tamada K, Geng D, Sakoda Y, Bansal N, Srivastava R, et al. 2012. Redirecting gene-modified T cells toward various cancer types using tagged antibodies. Clin. Cancer Res. 18:6436-45
    • (2012) Clin. Cancer Res. , vol.18 , pp. 6436-6445
    • Tamada, K.1    Geng, D.2    Sakoda, Y.3    Bansal, N.4    Srivastava, R.5
  • 132
    • 84859383718 scopus 로고    scopus 로고
    • A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor
    • Urbanska K, Lanitis E, Poussin M, Lynn RC, Gavin BP, et al. 2012. A universal strategy for adoptive immunotherapy of cancer through use of a novel T-cell antigen receptor. Cancer Res. 72:1844-52
    • (2012) Cancer Res. , vol.72 , pp. 1844-1852
    • Urbanska, K.1    Lanitis, E.2    Poussin, M.3    Lynn, R.C.4    Gavin, B.P.5
  • 133
    • 84891708419 scopus 로고    scopus 로고
    • PD-1-and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses
    • Fedorov VD, Themeli M, Sadelain M. 2013. PD-1-and CTLA-4-based inhibitory chimeric antigen receptors (iCARs) divert off-target immunotherapy responses. Sci. Transl. Med. 5:215ra172
    • (2013) Sci. Transl. Med. , vol.5 , pp. 215ra172
    • Fedorov, V.D.1    Themeli, M.2    Sadelain, M.3
  • 135
    • 19344365874 scopus 로고    scopus 로고
    • An inducible caspase 9 safety switch for T-cell therapy
    • Straathof KC, Pule MA, Yotnda P, Dotti G, Vanin EF, et al. 2005. An inducible caspase 9 safety switch for T-cell therapy. Blood 105:4247-54
    • (2005) Blood , vol.105 , pp. 4247-4254
    • Straathof, K.C.1    Pule, M.A.2    Yotnda, P.3    Dotti, G.4    Vanin, E.F.5
  • 136
    • 78349255049 scopus 로고    scopus 로고
    • Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses
    • Peng W, Ye Y, Rabinovich BA, Liu C, Lou Y, et al. 2010. Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses. Clin. Cancer Res. 16:5458-68
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5458-5468
    • Peng, W.1    Ye, Y.2    Rabinovich, B.A.3    Liu, C.4    Lou, Y.5
  • 137
    • 79960403269 scopus 로고    scopus 로고
    • Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor
    • Moon EK, Carpenito C, Sun J, Wang LC, Kapoor V, et al. 2011. Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor. Clin. Cancer Res. 17:4719-30
    • (2011) Clin. Cancer Res. , vol.17 , pp. 4719-4730
    • Moon, E.K.1    Carpenito, C.2    Sun, J.3    Wang, L.C.4    Kapoor, V.5
  • 138
    • 84899628388 scopus 로고    scopus 로고
    • Optogenetic control of chemokine receptor signal and T-cell migration
    • Xu Y, Hyun YM, Lim K, Lee H, Cummings RJ, et al. 2014. Optogenetic control of chemokine receptor signal and T-cell migration. PNAS 111:6371-76
    • (2014) PNAS , vol.111 , pp. 6371-6376
    • Xu, Y.1    Hyun, Y.M.2    Lim, K.3    Lee, H.4    Cummings, R.J.5
  • 139
    • 84937758074 scopus 로고    scopus 로고
    • Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
    • Caruana I, Savoldo B, Hoyos V, Weber G, Liu H, et al. 2015. Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes. Nat. Med. 21:524-29
    • (2015) Nat. Med. , vol.21 , pp. 524-529
    • Caruana, I.1    Savoldo, B.2    Hoyos, V.3    Weber, G.4    Liu, H.5
  • 140
    • 84877788719 scopus 로고    scopus 로고
    • Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy
    • Zhang L, Yu Z, Muranski P, Palmer DC, Restifo NP, et al. 2013. Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy. Gene Ther. 20:575-80
    • (2013) Gene Ther. , vol.20 , pp. 575-580
    • Zhang, L.1    Yu, Z.2    Muranski, P.3    Palmer, D.C.4    Restifo, N.P.5
  • 141
    • 84902146901 scopus 로고    scopus 로고
    • Reversal of tumor immune inhibition using a chimeric cytokine receptor
    • Leen AM, Sukumaran S, Watanabe N, Mohammed S, Keirnan J, et al. 2014. Reversal of tumor immune inhibition using a chimeric cytokine receptor. Mol. Ther. 22:1211-20
    • (2014) Mol. Ther. , vol.22 , pp. 1211-1220
    • Leen, A.M.1    Sukumaran, S.2    Watanabe, N.3    Mohammed, S.4    Keirnan, J.5
  • 142
    • 84861224393 scopus 로고    scopus 로고
    • Tumor PD-L1 co-stimulates primary human CD8+ cytotoxic T cells modified to express a PD1:CD28 chimeric receptor
    • ProsserME, Brown CE, Shami AF, Forman SJ, Jensen MC. 2012. Tumor PD-L1 co-stimulates primary human CD8+ cytotoxic T cells modified to express a PD1:CD28 chimeric receptor. Mol. Immunol. 51:263-72
    • (2012) Mol. Immunol. , vol.51 , pp. 263-272
    • Prosser, M.E.1    Brown, C.E.2    Shami, A.F.3    Forman, S.J.4    Jensen, M.C.5
  • 143
    • 70449641034 scopus 로고    scopus 로고
    • Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity
    • Komita H, Zhao X, Katakam AK, Kumar P, Kawabe M, et al. 2009. Conditional interleukin-12 gene therapy promotes safe and effective antitumor immunity. Cancer Gene Ther. 16:883-91
    • (2009) Cancer Gene Ther. , vol.16 , pp. 883-891
    • Komita, H.1    Zhao, X.2    Katakam, A.K.3    Kumar, P.4    Kawabe, M.5
  • 144
    • 84929433571 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy ofmetastatic melanoma
    • Zhang L,Morgan RA, Beane JD, Zheng Z,Dudley ME, et al. 2015. Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy ofmetastatic melanoma. Clin. Cancer Res. 21:2278-88
    • (2015) Clin. Cancer Res. , vol.21 , pp. 2278-2288
    • Zhang, L.1    Morgan, R.A.2    Beane, J.D.3    Zheng, Z.4    Dudley, M.E.5
  • 145
    • 85011392403 scopus 로고    scopus 로고
    • Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
    • Qasim W, Zhan H, Samarasinghe S, Adams S, Amrolia P, et al. 2017. Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells. Sci. Transl. Med. 9:eaaj2013
    • (2017) Sci. Transl. Med. , vol.9 , pp. eaaj2013
    • Qasim, W.1    Zhan, H.2    Samarasinghe, S.3    Adams, S.4    Amrolia, P.5
  • 147
    • 84872176550 scopus 로고    scopus 로고
    • Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease
    • Kwong GA, vonMaltzahn G,Murugappan G, Abudayyeh O, Mo S, et al. 2013. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat. Biotechnol. 31:63-70
    • (2013) Nat. Biotechnol. , vol.31 , pp. 63-70
    • Kwong, G.A.1    VonMaltzahn, G.2    Murugappan, G.3    Abudayyeh, O.4    Mo, S.5
  • 148
    • 85029919483 scopus 로고    scopus 로고
    • Ultrasensitive tumour-penetrating nanosensors of protease activity
    • Kwon EJ, Dudani JS, Bhatia SN. 2017. Ultrasensitive tumour-penetrating nanosensors of protease activity. Nat. Biomed. Eng. 1:0054
    • (2017) Nat. Biomed. Eng. , vol.1 , pp. 0054
    • Kwon, E.J.1    Dudani, J.S.2    Bhatia, S.N.3
  • 149
    • 84958093401 scopus 로고    scopus 로고
    • Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
    • Baker DJ, Childs BG, DurikM,WijersME, Sieben CJ, et al. 2016. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan. Nature 530:184-89
    • (2016) Nature , vol.530 , pp. 184-189
    • Baker, D.J.1    Childs, B.G.2    Durik, M.3    Wijers, M.E.4    Sieben, C.J.5
  • 150
    • 84954218515 scopus 로고    scopus 로고
    • Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
    • Chang J,Wang Y, Shao L, Laberge RM,Demaria M, et al. 2016. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat. Med. 22:78-83
    • (2016) Nat. Med. , vol.22 , pp. 78-83
    • Chang, J.1    Wang, Y.2    Shao, L.3    Laberge, R.M.4    Demaria, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.