Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

Nature Biotechnology

Volumn 35, Issue 5, 2017, Pages 453-462

  Weinberg, Benjamin H ^a   Pham, N T Hang ^a   Caraballo, Leidy D ^a   Lozanoski, Thomas ^a   Engel, Adrien ^a,b   Bhatia, Swapnil ^a   Wong, Wilson W ^a  

^a Boston University   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ENGINEERING; CELLS; COMPUTATION THEORY; CYTOLOGY; ELECTRIC NETWORK ANALYSIS; LOGIC CIRCUITS; MAMMALS; TABLE LOOKUP; TIMING CIRCUITS; TISSUE ENGINEERING;

BOOLEAN LOGIC; ENDOGENOUS GENES; GENETIC CIRCUITS; HUMAN EMBRYONIC KIDNEYS; MAMMALIAN CELLS; MULTIPLE INPUTS AND OUTPUTS; SCALABLE SYSTEMS; SMALL MOLECULES;

COMPUTER CIRCUITS;

DNA; DOXYCYCLINE; GUIDE RNA; INTEGRASE; RECOMBINASE; PROTEOME;

ARTICLE; CELL ENGINEERING; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; INFORMATION SCIENCE; JURKAT CELL LINE; LOXP SITE; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RELIABILITY; SCALE UP; SOMATIC CELL GENETICS; TISSUE ENGINEERING; TRANSIENT TRANSFECTION; BIOLOGICAL MODEL; CELL REPROGRAMMING TECHNIQUE; COMPUTER SIMULATION; GENE REGULATORY NETWORK; GENETIC ENGINEERING; GENETICS; MOLECULAR COMPUTER; PROCEDURES; SIGNAL TRANSDUCTION;

CELLULAR REPROGRAMMING TECHNIQUES; COMPUTER SIMULATION; COMPUTERS, MOLECULAR; GENE REGULATORY NETWORKS; GENETIC ENGINEERING; HUMANS; JURKAT CELLS; MODELS, GENETIC; PROTEOME; SIGNAL TRANSDUCTION;

EID: 85019107155     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3805     Document Type: Article

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