Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

Science

Volumn 353, Issue 6295, 2016, Pages 179-184

  Ellebrecht, Christoph T ^a   Bhoj, Vijay G ^a   Nace, Arben ^a   Choi, Eun Jung ^a   Mao, Xuming ^a   Cho, Michael Jeffrey ^a   Di Zenzo, Giovanni ^b   Lanzavecchia, Antonio ^c   Seykora, John T ^a   Cotsarelis, George ^a   Milone, Michael C ^a   Payne, Aimee S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; B LYMPHOCYTE RECEPTOR; CHIMERIC AUTOANTIBODY RECEPTOR; DESMOGLEIN 3; GAMMA INTERFERON; IMMUNOGLOBULIN G; T LYMPHOCYTE RECEPTOR; TISAGENLECLEUCEL T; UNCLASSIFIED DRUG; AUTOANTIBODY; CD137 ANTIGEN; CD3 ANTIGEN; CD3 ANTIGEN, ZETA CHAIN; HYBRID PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ANTIBODY; ANTIGEN; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ENGINEERING; GENOTOXICITY; IMMUNITY; SKIN DISORDER;

ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BINDING KINETICS; BIOLUMINESCENCE; COMPARATIVE STUDY; COMPETITIVE BINDING ASSAY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOLOGICAL SYNAPSE; IN VITRO STUDY; MOUSE; NONHUMAN; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; SKIN TOXICITY; SURFACE PLASMON RESONANCE; T LYMPHOCYTE ACTIVATION; ANIMAL; AUTOIMMUNITY; BLOOD; CELL ENGINEERING; CHEMISTRY; DISEASE MODEL; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; PEMPHIGUS; PROCEDURES; PROTEIN TERTIARY STRUCTURE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD137; ANTIGENS, CD3; AUTOANTIBODIES; AUTOIMMUNITY; B-LYMPHOCYTES; CELL ENGINEERING; CYTOTOXICITY, IMMUNOLOGIC; DESMOGLEIN 3; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOSUPPRESSION; MICE; PEMPHIGUS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES;

EID: 84976904277     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf6756     Document Type: Article

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