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Volumn 48, Issue 1, 2018, Pages 15-27

Reciprocal interactions between bile acids and gut microbiota in human liver diseases

Author keywords

bile acids; dysbiosis; farnesoid X receptor (FXR); gut microbiota

Indexed keywords

ANTIBIOTIC AGENT; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYCLIC AMP; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 5; TEMPOL;

EID: 85040107521     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.13001     Document Type: Review
Times cited : (35)

References (126)
  • 1
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006; 47: 241–259.
    • (2006) J Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 2
    • 0030773526 scopus 로고    scopus 로고
    • Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat
    • Vlahcevic ZR, Stravitz RT, Heuman DM, Hylemon PB, Pandak WM. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. Gastroenterology 1997; 113: 1949–1957.
    • (1997) Gastroenterology , vol.113 , pp. 1949-1957
    • Vlahcevic, Z.R.1    Stravitz, R.T.2    Heuman, D.M.3    Hylemon, P.B.4    Pandak, W.M.5
  • 3
    • 0032769064 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol: production rates in normal human subjects
    • Duane WC, Javitt NB. 27-Hydroxycholesterol: production rates in normal human subjects. J Lipid Res 1999; 40: 1194–1199.
    • (1999) J Lipid Res , vol.40 , pp. 1194-1199
    • Duane, W.C.1    Javitt, N.B.2
  • 4
    • 84951209574 scopus 로고    scopus 로고
    • Implications of microbiota and bile acid in liver injury and regeneration
    • Liu HX, Keane R, Sheng L, Wan YJ. Implications of microbiota and bile acid in liver injury and regeneration. J Hepatol 2015; 63: 1502–1510.
    • (2015) J Hepatol , vol.63 , pp. 1502-1510
    • Liu, H.X.1    Keane, R.2    Sheng, L.3    Wan, Y.J.4
  • 5
    • 85010383234 scopus 로고    scopus 로고
    • The ascending pathophysiology of cholestatic liver disease
    • Jansen PL, Ghallab A, Vartak N et al. The ascending pathophysiology of cholestatic liver disease. Hepatology 2017; 65: 722–738.
    • (2017) Hepatology , vol.65 , pp. 722-738
    • Jansen, P.L.1    Ghallab, A.2    Vartak, N.3
  • 6
    • 65649124573 scopus 로고    scopus 로고
    • Bile-acid-induced cell injury and protection
    • Perez MJ, Briz O. Bile-acid-induced cell injury and protection. World J Gastroenterol 2009; 15: 1677–1689.
    • (2009) World J Gastroenterol , vol.15 , pp. 1677-1689
    • Perez, M.J.1    Briz, O.2
  • 7
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H, Chen J, Hollister K, Sowers LC, Forman BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3: 543–553.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 8
    • 0037123667 scopus 로고    scopus 로고
    • Vitamin D receptor as an intestinal bile acid sensor
    • Makishima M, Lu TT, Xie W et al. Vitamin D receptor as an intestinal bile acid sensor. Science 2002; 296: 1313–1316.
    • (2002) Science , vol.296 , pp. 1313-1316
    • Makishima, M.1    Lu, T.T.2    Xie, W.3
  • 9
    • 0035853165 scopus 로고    scopus 로고
    • The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
    • Staudinger JL, Goodwin B, Jones SA et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 2001; 98: 3369–3374.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3369-3374
    • Staudinger, J.L.1    Goodwin, B.2    Jones, S.A.3
  • 10
    • 0003269455 scopus 로고    scopus 로고
    • A G protein-coupled receptor responsive to bile acids
    • Kawamata Y, Fujii R, Hosoya M et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003; 278: 9435–9440.
    • (2003) J Biol Chem , vol.278 , pp. 9435-9440
    • Kawamata, Y.1    Fujii, R.2    Hosoya, M.3
  • 11
    • 84989244927 scopus 로고    scopus 로고
    • The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases
    • Nagahashi M, Yuza K, Hirose Y et al. The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. J Lipid Res 2016; 57: 1636–1643.
    • (2016) J Lipid Res , vol.57 , pp. 1636-1643
    • Nagahashi, M.1    Yuza, K.2    Hirose, Y.3
  • 12
    • 77958099262 scopus 로고    scopus 로고
    • Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes
    • Sheikh Abdul Kadir SH, Miragoli M, Abu-Hayyeh S et al. Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes. PLoS One 2010; 5: e9689.
    • (2010) PLoS One , vol.5
    • Sheikh Abdul Kadir, S.H.1    Miragoli, M.2    Abu-Hayyeh, S.3
  • 13
    • 58249110568 scopus 로고    scopus 로고
    • Role of bile acids and bile acid receptors in metabolic regulation
    • Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147–191.
    • (2009) Physiol Rev , vol.89 , pp. 147-191
    • Lefebvre, P.1    Cariou, B.2    Lien, F.3    Kuipers, F.4    Staels, B.5
  • 14
    • 84923031534 scopus 로고    scopus 로고
    • Nutrient-sensing nuclear receptors coordinate autophagy
    • Lee JM, Wagner M, Xiao R et al. Nutrient-sensing nuclear receptors coordinate autophagy. Nature 2014; 516: 112–115.
    • (2014) Nature , vol.516 , pp. 112-115
    • Lee, J.M.1    Wagner, M.2    Xiao, R.3
  • 15
    • 84922968506 scopus 로고    scopus 로고
    • Transcriptional regulation of autophagy by an FXR–CREB axis
    • Seok S, Fu T, Choi SE et al. Transcriptional regulation of autophagy by an FXR–CREB axis. Nature 2014; 516: 108–111.
    • (2014) Nature , vol.516 , pp. 108-111
    • Seok, S.1    Fu, T.2    Choi, S.E.3
  • 16
    • 85047694456 scopus 로고    scopus 로고
    • Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
    • Watanabe M, Houten SM, Wang L et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004; 113: 1408–1418.
    • (2004) J Clin Invest , vol.113 , pp. 1408-1418
    • Watanabe, M.1    Houten, S.M.2    Wang, L.3
  • 17
    • 84923066154 scopus 로고    scopus 로고
    • FXR agonists as therapeutic agents for non-alcoholic fatty liver disease
    • Carr RM, Reid AE. FXR agonists as therapeutic agents for non-alcoholic fatty liver disease. Curr Atheroscler Rep 2015; 17: 500.
    • (2015) Curr Atheroscler Rep , vol.17 , pp. 500
    • Carr, R.M.1    Reid, A.E.2
  • 18
    • 84947201682 scopus 로고    scopus 로고
    • Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids
    • Ferrebee CB, Dawson PA. Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids. Acta Pharm Sin B 2015; 5: 129–134.
    • (2015) Acta Pharm Sin B , vol.5 , pp. 129-134
    • Ferrebee, C.B.1    Dawson, P.A.2
  • 19
    • 84949105963 scopus 로고    scopus 로고
    • Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease
    • Jahn D, Rau M, Hermanns HM, Geier A. Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease. Cytokine Growth Factor Rev 2015; 26: 625–635.
    • (2015) Cytokine Growth Factor Rev , vol.26 , pp. 625-635
    • Jahn, D.1    Rau, M.2    Hermanns, H.M.3    Geier, A.4
  • 20
    • 84958206076 scopus 로고    scopus 로고
    • Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease
    • Fuchs CD, Traussnigg SA, Trauner M. Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease. Semin Liver Dis 2016; 36: 69–86.
    • (2016) Semin Liver Dis , vol.36 , pp. 69-86
    • Fuchs, C.D.1    Traussnigg, S.A.2    Trauner, M.3
  • 21
    • 84931317994 scopus 로고    scopus 로고
    • Nuclear bile acid signaling through the farnesoid X receptor
    • Mazuy C, Helleboid A, Staels B, Lefebvre P. Nuclear bile acid signaling through the farnesoid X receptor. Cell Mol Life Sci 2015; 72: 1631–1650.
    • (2015) Cell Mol Life Sci , vol.72 , pp. 1631-1650
    • Mazuy, C.1    Helleboid, A.2    Staels, B.3    Lefebvre, P.4
  • 22
    • 79959975693 scopus 로고    scopus 로고
    • Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
    • Cariou B, Chetiveaux M, Zair Y et al. Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults. Nutr Metab (Lond) 2011; 8: 48.
    • (2011) Nutr Metab (Lond) , vol.8 , pp. 48
    • Cariou, B.1    Chetiveaux, M.2    Zair, Y.3
  • 23
    • 79956088562 scopus 로고    scopus 로고
    • The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
    • Pols TW, Noriega LG, Nomura M, Auwerx J, Schoonjans K. The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol 2011; 54: 1263–1272.
    • (2011) J Hepatol , vol.54 , pp. 1263-1272
    • Pols, T.W.1    Noriega, L.G.2    Nomura, M.3    Auwerx, J.4    Schoonjans, K.5
  • 24
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • Thomas C, Gioiello A, Noriega L et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009; 10: 167–177.
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 25
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006; 439: 484–489.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3
  • 26
    • 84940719531 scopus 로고    scopus 로고
    • The bile acid chenodeoxycholic acid increases human brown adipose tissue activity
    • Broeders EP, Nascimento EB, Havekes B et al. The bile acid chenodeoxycholic acid increases human brown adipose tissue activity. Cell Metab 2015; 22: 418–426.
    • (2015) Cell Metab , vol.22 , pp. 418-426
    • Broeders, E.P.1    Nascimento, E.B.2    Havekes, B.3
  • 27
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131–2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 28
    • 33750914846 scopus 로고    scopus 로고
    • Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level
    • Alarcon C, Wicksteed B, Rhodes CJ. Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level. Diabetologia 2006; 49: 2920–2929.
    • (2006) Diabetologia , vol.49 , pp. 2920-2929
    • Alarcon, C.1    Wicksteed, B.2    Rhodes, C.J.3
  • 29
    • 0033591387 scopus 로고    scopus 로고
    • Bile acids: natural ligands for an orphan nuclear receptor
    • Parks DJ, Blanchard SG, Bledsoe RK et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999; 284: 1365–1368.
    • (1999) Science , vol.284 , pp. 1365-1368
    • Parks, D.J.1    Blanchard, S.G.2    Bledsoe, R.K.3
  • 30
    • 84871124415 scopus 로고    scopus 로고
    • A metagenomic insight into our gut's microbiome
    • Lepage P, Leclerc MC, Joossens M et al. A metagenomic insight into our gut's microbiome. Gut 2013; 62: 146–158.
    • (2013) Gut , vol.62 , pp. 146-158
    • Lepage, P.1    Leclerc, M.C.2    Joossens, M.3
  • 31
    • 79251584066 scopus 로고    scopus 로고
    • Bifidobacteria can protect from enteropathogenic infection through production of acetate
    • Fukuda S, Toh H, Hase K et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 2011; 469: 543–547.
    • (2011) Nature , vol.469 , pp. 543-547
    • Fukuda, S.1    Toh, H.2    Hase, K.3
  • 32
    • 0028126829 scopus 로고
    • The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations
    • Collins MD, Lawson PA, Willems A et al. The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations. Int J Syst Bacteriol 1994; 44: 812–826.
    • (1994) Int J Syst Bacteriol , vol.44 , pp. 812-826
    • Collins, M.D.1    Lawson, P.A.2    Willems, A.3
  • 33
    • 84941347610 scopus 로고    scopus 로고
    • Impact of commensal microbiota on the host pathophysiology: focusing on immunity and inflammation
    • Ohno H. Impact of commensal microbiota on the host pathophysiology: focusing on immunity and inflammation. Semin Immunopathol 2015; 37: 1–3.
    • (2015) Semin Immunopathol , vol.37 , pp. 1-3
    • Ohno, H.1
  • 34
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • Qin J, Li Y, Cai Z et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012; 490: 55–60.
    • (2012) Nature , vol.490 , pp. 55-60
    • Qin, J.1    Li, Y.2    Cai, Z.3
  • 35
    • 84871814687 scopus 로고    scopus 로고
    • Symptomatic atherosclerosis is associated with an altered gut metagenome
    • Karlsson FH, Fak F, Nookaew I et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun 2012; 3: 1245.
    • (2012) Nat Commun , vol.3 , pp. 1245
    • Karlsson, F.H.1    Fak, F.2    Nookaew, I.3
  • 36
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • Tang WH, Wang Z, Levison BS et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013; 368: 1575–1584.
    • (2013) N Engl J Med , vol.368 , pp. 1575-1584
    • Tang, W.H.1    Wang, Z.2    Levison, B.S.3
  • 37
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • Turnbaugh PJ, Hamady M, Yatsunenko T et al. A core gut microbiome in obese and lean twins. Nature 2009; 457: 480–484.
    • (2009) Nature , vol.457 , pp. 480-484
    • Turnbaugh, P.J.1    Hamady, M.2    Yatsunenko, T.3
  • 38
    • 84987602337 scopus 로고    scopus 로고
    • Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation
    • Fujimura KE, Sitarik AR, Havstad S et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med 2016; 22: 1187–1191.
    • (2016) Nat Med , vol.22 , pp. 1187-1191
    • Fujimura, K.E.1    Sitarik, A.R.2    Havstad, S.3
  • 39
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao EY, McBride SW, Hsien S et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013; 155: 1451–1463.
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1    McBride, S.W.2    Hsien, S.3
  • 40
    • 84947447931 scopus 로고    scopus 로고
    • Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridia XIVa and IV clusters
    • Miyake S, Kim S, Suda W et al. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridia XIVa and IV clusters. PLoS One 2015; 10: e0137429.
    • (2015) PLoS One , vol.10
    • Miyake, S.1    Kim, S.2    Suda, W.3
  • 41
    • 84951284320 scopus 로고    scopus 로고
    • Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson's disease
    • Hasegawa S, Goto S, Tsuji H et al. Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson's disease. PLoS One 2015; 10: e0142164.
    • (2015) PLoS One , vol.10
    • Hasegawa, S.1    Goto, S.2    Tsuji, H.3
  • 42
    • 84879604697 scopus 로고    scopus 로고
    • Intestinal microbiota in patients with nonalcoholic fatty liver disease
    • Mouzaki M, Comelli EM, Arendt BM et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology 2013; 58: 120–127.
    • (2013) Hepatology , vol.58 , pp. 120-127
    • Mouzaki, M.1    Comelli, E.M.2    Arendt, B.M.3
  • 43
    • 84954288595 scopus 로고    scopus 로고
    • The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
    • Boursier J, Mueller O, Barret M et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 2016; 63: 764–775.
    • (2016) Hepatology , vol.63 , pp. 764-775
    • Boursier, J.1    Mueller, O.2    Barret, M.3
  • 44
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S, Loo TM, Atarashi K et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013; 499: 97–101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3
  • 45
    • 84925486076 scopus 로고    scopus 로고
    • The gut microbiota and inflammatory bowel disease
    • Matsuoka K, Kanai T. The gut microbiota and inflammatory bowel disease. Semin Immunopathol 2015; 37: 47–55.
    • (2015) Semin Immunopathol , vol.37 , pp. 47-55
    • Matsuoka, K.1    Kanai, T.2
  • 46
    • 57649179488 scopus 로고    scopus 로고
    • Faecal microbiota profile of Crohn's disease determined by terminal restriction fragment length polymorphism analysis
    • Andoh A, Tsujikawa T, Sasaki M et al. Faecal microbiota profile of Crohn's disease determined by terminal restriction fragment length polymorphism analysis. Aliment Pharmacol Ther 2009; 29: 75–82.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 75-82
    • Andoh, A.1    Tsujikawa, T.2    Sasaki, M.3
  • 47
    • 79953748870 scopus 로고    scopus 로고
    • Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
    • Joossens M, Huys G, Cnockaert M et al. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 2011; 60: 631–637.
    • (2011) Gut , vol.60 , pp. 631-637
    • Joossens, M.1    Huys, G.2    Cnockaert, M.3
  • 48
    • 84871530893 scopus 로고    scopus 로고
    • Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis
    • Nemoto H, Kataoka K, Ishikawa H et al. Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis. Dig Dis Sci 2012; 57: 2955–2964.
    • (2012) Dig Dis Sci , vol.57 , pp. 2955-2964
    • Nemoto, H.1    Kataoka, K.2    Ishikawa, H.3
  • 49
    • 84931423571 scopus 로고    scopus 로고
    • Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis
    • Rossen NG, Fuentes S, van der Spek MJ et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 2015; 149: 110–8.e4.
    • (2015) Gastroenterology , vol.149 , pp. 110-8.e4
    • Rossen, N.G.1    Fuentes, S.2    van der Spek, M.J.3
  • 50
    • 34447104397 scopus 로고    scopus 로고
    • The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects
    • Kassinen A, Krogius-Kurikka L, Makivuokko H et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 2007; 133: 24–33.
    • (2007) Gastroenterology , vol.133 , pp. 24-33
    • Kassinen, A.1    Krogius-Kurikka, L.2    Makivuokko, H.3
  • 51
    • 85005965070 scopus 로고    scopus 로고
    • The human intestinal microbiome in health and disease
    • Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med 2016; 375: 2369–2379.
    • (2016) N Engl J Med , vol.375 , pp. 2369-2379
    • Lynch, S.V.1    Pedersen, O.2
  • 52
  • 53
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012; 489: 242–249.
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Backhed, F.2
  • 54
    • 85014611332 scopus 로고    scopus 로고
    • Disease-associated changes in bile acid profiles and links to altered gut microbiota
    • Joyce SA, Gahan CG. Disease-associated changes in bile acid profiles and links to altered gut microbiota. Dig Dis 2017; 35: 169–177.
    • (2017) Dig Dis , vol.35 , pp. 169-177
    • Joyce, S.A.1    Gahan, C.G.2
  • 55
    • 84901020405 scopus 로고    scopus 로고
    • Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
    • Joyce SA, MacSharry J, Casey PG et al. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci USA 2014; 111: 7421–7426.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 7421-7426
    • Joyce, S.A.1    MacSharry, J.2    Casey, P.G.3
  • 56
    • 84922021716 scopus 로고    scopus 로고
    • Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe–host crosstalk
    • Joyce SA, Shanahan F, Hill C, Gahan CG. Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe–host crosstalk. Gut Microbes 2014; 5: 669–674.
    • (2014) Gut Microbes , vol.5 , pp. 669-674
    • Joyce, S.A.1    Shanahan, F.2    Hill, C.3    Gahan, C.G.4
  • 57
    • 0029041833 scopus 로고
    • Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens
    • Coleman JP, Hudson LL. Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens. Appl Environ Microbiol 1995; 61: 2514–2520.
    • (1995) Appl Environ Microbiol , vol.61 , pp. 2514-2520
    • Coleman, J.P.1    Hudson, L.L.2
  • 58
    • 0026446050 scopus 로고
    • Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay
    • Christiaens H, Leer RJ, Pouwels PH, Verstraete W. Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay. Appl Environ Microbiol 1992; 58: 3792–3798.
    • (1992) Appl Environ Microbiol , vol.58 , pp. 3792-3798
    • Christiaens, H.1    Leer, R.J.2    Pouwels, P.H.3    Verstraete, W.4
  • 59
    • 0031720810 scopus 로고    scopus 로고
    • Identification of genes encoding conjugated bile salt hydrolase and transport in Lactobacillus johnsonii 100-100
    • Elkins CA, Savage DC. Identification of genes encoding conjugated bile salt hydrolase and transport in Lactobacillus johnsonii 100-100. J Bacteriol 1998; 180: 4344–4349.
    • (1998) J Bacteriol , vol.180 , pp. 4344-4349
    • Elkins, C.A.1    Savage, D.C.2
  • 60
    • 0034048222 scopus 로고    scopus 로고
    • Bile salt hydrolase of Bifidobacterium longum –biochemical and genetic characterization
    • Tanaka H, Hashiba H, Kok J, Mierau I. Bile salt hydrolase of Bifidobacterium longum –biochemical and genetic characterization. Appl Environ Microbiol 2000; 66: 2502–2512.
    • (2000) Appl Environ Microbiol , vol.66 , pp. 2502-2512
    • Tanaka, H.1    Hashiba, H.2    Kok, J.3    Mierau, I.4
  • 61
    • 0024058679 scopus 로고
    • Purification and characterization of bile salt hydrolase from Clostridium perfringens
    • Gopal-Srivastava R, Hylemon PB. Purification and characterization of bile salt hydrolase from Clostridium perfringens. J Lipid Res 1988; 29: 1079–1085.
    • (1988) J Lipid Res , vol.29 , pp. 1079-1085
    • Gopal-Srivastava, R.1    Hylemon, P.B.2
  • 62
    • 0018332888 scopus 로고
    • 7α-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum
    • Stellwag EJ, Hylemon PB. 7α-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum. J Lipid Res 1979; 20: 325–333.
    • (1979) J Lipid Res , vol.20 , pp. 325-333
    • Stellwag, E.J.1    Hylemon, P.B.2
  • 63
    • 0035155058 scopus 로고    scopus 로고
    • Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7α-dehydroxylating activity
    • Kitahara M, Takamine F, Imamura T, Benno Y. Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7α-dehydroxylating activity. Int J Syst Evol Microbiol 2001; 51: 39–44.
    • (2001) Int J Syst Evol Microbiol , vol.51 , pp. 39-44
    • Kitahara, M.1    Takamine, F.2    Imamura, T.3    Benno, Y.4
  • 64
    • 0034034841 scopus 로고    scopus 로고
    • Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7α-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces
    • Kitahara M, Takamine F, Imamura T, Benno Y. Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7α-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 2000; 50(Pt 3): 971–978.
    • (2000) Int J Syst Evol Microbiol , vol.50 , pp. 971-978
    • Kitahara, M.1    Takamine, F.2    Imamura, T.3    Benno, Y.4
  • 65
    • 84883442887 scopus 로고    scopus 로고
    • Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship
    • Ridlon JM, Alves JM, Hylemon PB, Bajaj JS. Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship. Gut Microbes 2013; 4: 382–387.
    • (2013) Gut Microbes , vol.4 , pp. 382-387
    • Ridlon, J.M.1    Alves, J.M.2    Hylemon, P.B.3    Bajaj, J.S.4
  • 67
    • 80054862011 scopus 로고    scopus 로고
    • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats
    • Islam KB, Fukiya S, Hagio M et al. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 2011; 141: 1773–1781.
    • (2011) Gastroenterology , vol.141 , pp. 1773-1781
    • Islam, K.B.1    Fukiya, S.2    Hagio, M.3
  • 68
    • 84866040724 scopus 로고    scopus 로고
    • Is bile acid a determinant of the gut microbiota on a high-fat diet?
    • Yokota A, Fukiya S, Islam KB et al. Is bile acid a determinant of the gut microbiota on a high-fat diet? Gut Microbes 2012; 3: 455–459.
    • (2012) Gut Microbes , vol.3 , pp. 455-459
    • Yokota, A.1    Fukiya, S.2    Islam, K.B.3
  • 69
    • 85021078907 scopus 로고    scopus 로고
    • Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents
    • Watanabe M, Fukiya S, Yokota A. Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents. J Lipid Res 2017; 58: 1143–1152.
    • (2017) J Lipid Res , vol.58 , pp. 1143-1152
    • Watanabe, M.1    Fukiya, S.2    Yokota, A.3
  • 70
    • 85040102149 scopus 로고    scopus 로고
    • Detection of gut dysbiosis due to reduced Clostridium subcluster XIVa by based on the serum bile acid profile
    • (in press)
    • Murakami M, Iwamoto J, Miyazaki T et al. Detection of gut dysbiosis due to reduced Clostridium subcluster XIVa by based on the serum bile acid profile. Inflamm Bowel Dis (in press).
    • Inflamm Bowel Dis
    • Murakami, M.1    Iwamoto, J.2    Miyazaki, T.3
  • 71
    • 84938057875 scopus 로고    scopus 로고
    • Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease
    • Angulo P, Kleiner DE, Dam-Larsen S et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 2015; 149: 389–97.e10.
    • (2015) Gastroenterology , vol.149 , pp. 389-97.e10
    • Angulo, P.1    Kleiner, D.E.2    Dam-Larsen, S.3
  • 72
    • 84955267511 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
    • Musso G, Cassader M, Gambino R. Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies. Nat Rev Drug Discov 2016; 15: 249–274.
    • (2016) Nat Rev Drug Discov , vol.15 , pp. 249-274
    • Musso, G.1    Cassader, M.2    Gambino, R.3
  • 73
    • 84887477319 scopus 로고    scopus 로고
    • Bile acid receptors in non-alcoholic fatty liver disease
    • Li Y, Jadhav K, Zhang Y. Bile acid receptors in non-alcoholic fatty liver disease. Biochem Pharmacol 2013; 86: 1517–1524.
    • (2013) Biochem Pharmacol , vol.86 , pp. 1517-1524
    • Li, Y.1    Jadhav, K.2    Zhang, Y.3
  • 75
    • 84941918492 scopus 로고    scopus 로고
    • The gut microbiota and nonalcoholic fatty liver disease
    • Quigley EM, Monsour HP. The gut microbiota and nonalcoholic fatty liver disease. Semin Liver Dis 2015; 35: 262–269.
    • (2015) Semin Liver Dis , vol.35 , pp. 262-269
    • Quigley, E.M.1    Monsour, H.P.2
  • 76
    • 84951843544 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and the gut microbiome
    • Boursier J, Diehl AM. Nonalcoholic fatty liver disease and the gut microbiome. Clin Liver Dis 2016; 20: 263–275.
    • (2016) Clin Liver Dis , vol.20 , pp. 263-275
    • Boursier, J.1    Diehl, A.M.2
  • 77
    • 84930583108 scopus 로고    scopus 로고
    • Bile acid signaling: mechanism for bariatric surgery, cure for NASH?
    • Kohli R, Myronovych A, Tan BK et al. Bile acid signaling: mechanism for bariatric surgery, cure for NASH? Dig Dis 2015; 33: 440–446.
    • (2015) Dig Dis , vol.33 , pp. 440-446
    • Kohli, R.1    Myronovych, A.2    Tan, B.K.3
  • 78
  • 79
    • 84945465558 scopus 로고    scopus 로고
    • Altered bile acid metabolome in patients with nonalcoholic steatohepatitis
    • Ferslew BC, Xie G, Johnston CK et al. Altered bile acid metabolome in patients with nonalcoholic steatohepatitis. Dig Dis Sci 2015; 60: 3318–3328.
    • (2015) Dig Dis Sci , vol.60 , pp. 3318-3328
    • Ferslew, B.C.1    Xie, G.2    Johnston, C.K.3
  • 80
    • 43449094989 scopus 로고    scopus 로고
    • Bile acid levels are increased in the liver of patients with steatohepatitis
    • Aranha MM, Cortez-Pinto H, Costa A et al. Bile acid levels are increased in the liver of patients with steatohepatitis. Eur J Gastroenterol Hepatol 2008; 20: 519–525.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 519-525
    • Aranha, M.M.1    Cortez-Pinto, H.2    Costa, A.3
  • 81
    • 79951792246 scopus 로고    scopus 로고
    • Plasma metabolomic profile in nonalcoholic fatty liver disease
    • Kalhan SC, Guo L, Edmison J et al. Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism 2011; 60: 404–413.
    • (2011) Metabolism , vol.60 , pp. 404-413
    • Kalhan, S.C.1    Guo, L.2    Edmison, J.3
  • 82
    • 84991519034 scopus 로고    scopus 로고
    • Bile acids and dysbiosis in non-alcoholic fatty liver disease
    • Mouzaki M, Wang AY, Bandsma R et al. Bile acids and dysbiosis in non-alcoholic fatty liver disease. PLoS One 2016; 11: e0151829.
    • (2016) PLoS One , vol.11
    • Mouzaki, M.1    Wang, A.Y.2    Bandsma, R.3
  • 83
    • 85048040313 scopus 로고    scopus 로고
    • Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD
    • gutjnl-2017-314307
    • Jiao N, Baker SS, Chapa-Rodriguez A et al. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut 2017; gutjnl-2017-314307.
    • (2017) Gut
    • Jiao, N.1    Baker, S.S.2    Chapa-Rodriguez, A.3
  • 84
    • 84884414277 scopus 로고    scopus 로고
    • Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
    • Le Roy T, Llopis M, Lepage P et al. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut 2013; 62: 1787–1794.
    • (2013) Gut , vol.62 , pp. 1787-1794
    • Le Roy, T.1    Llopis, M.2    Lepage, P.3
  • 85
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J, Elinav E, Jin C et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482: 179–185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3
  • 86
    • 84899474318 scopus 로고    scopus 로고
    • Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice
    • De Minicis S, Rychlicki C, Agostinelli L et al. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice. Hepatology 2014; 59: 1738–1749.
    • (2014) Hepatology , vol.59 , pp. 1738-1749
    • De Minicis, S.1    Rychlicki, C.2    Agostinelli, L.3
  • 87
    • 85018954191 scopus 로고    scopus 로고
    • Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease
    • Loomba R, Seguritan V, Li W et al. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 2017; 25: 1054–62.e5.
    • (2017) Cell Metab , vol.25 , pp. 1054-62.e5
    • Loomba, R.1    Seguritan, V.2    Li, W.3
  • 88
    • 85016485058 scopus 로고    scopus 로고
    • Finding the cure for primary biliary cholangitis – still waiting
    • Tanaka A, Gershwin ME. Finding the cure for primary biliary cholangitis – still waiting. Liver Int 2017; 37: 500–502.
    • (2017) Liver Int , vol.37 , pp. 500-502
    • Tanaka, A.1    Gershwin, M.E.2
  • 89
    • 84958161655 scopus 로고    scopus 로고
    • Primary biliary cirrhosis beyond ursodeoxycholic acid
    • Corpechot C. Primary biliary cirrhosis beyond ursodeoxycholic acid. Semin Liver Dis 2016; 36: 15–26.
    • (2016) Semin Liver Dis , vol.36 , pp. 15-26
    • Corpechot, C.1
  • 90
    • 84958182341 scopus 로고    scopus 로고
    • New therapeutic strategies for primary sclerosing cholangitis
    • Williamson KD, Chapman RW. New therapeutic strategies for primary sclerosing cholangitis. Semin Liver Dis 2016; 36: 5–14.
    • (2016) Semin Liver Dis , vol.36 , pp. 5-14
    • Williamson, K.D.1    Chapman, R.W.2
  • 91
    • 84953449930 scopus 로고    scopus 로고
    • A review of the medical treatment of primary sclerosing cholangitis in the 21st century
    • Goode EC, Rushbrook SM. A review of the medical treatment of primary sclerosing cholangitis in the 21st century. Ther Adv Chronic Dis 2016; 7: 68–85.
    • (2016) Ther Adv Chronic Dis , vol.7 , pp. 68-85
    • Goode, E.C.1    Rushbrook, S.M.2
  • 92
    • 85025127280 scopus 로고    scopus 로고
    • Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases
    • Li Y, Tang R, Leung PSC, Gershwin ME, Ma X. Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases. Autoimmun Rev 2017; 16: 885–896.
    • (2017) Autoimmun Rev , vol.16 , pp. 885-896
    • Li, Y.1    Tang, R.2    Leung, P.S.C.3    Gershwin, M.E.4    Ma, X.5
  • 93
    • 84995579603 scopus 로고    scopus 로고
    • Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis
    • Hisamoto S, Shimoda S, Harada K et al. Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis. J Autoimmun 2016; 75: 150–160.
    • (2016) J Autoimmun , vol.75 , pp. 150-160
    • Hisamoto, S.1    Shimoda, S.2    Harada, K.3
  • 94
    • 33744945790 scopus 로고    scopus 로고
    • Biliary obstruction selectively expands and activates liver myeloid dendritic cells
    • Bleier JI, Katz SC, Chaudhry UI et al. Biliary obstruction selectively expands and activates liver myeloid dendritic cells. J Immunol 2006; 176: 7189–7195.
    • (2006) J Immunol , vol.176 , pp. 7189-7195
    • Bleier, J.I.1    Katz, S.C.2    Chaudhry, U.I.3
  • 95
    • 0032558588 scopus 로고    scopus 로고
    • Molecular pathogenesis of cholestasis
    • Trauner M, Meier PJ, Boyer JL. Molecular pathogenesis of cholestasis. N Engl J Med 1998; 339: 1217–1227.
    • (1998) N Engl J Med , vol.339 , pp. 1217-1227
    • Trauner, M.1    Meier, P.J.2    Boyer, J.L.3
  • 96
    • 84856159269 scopus 로고    scopus 로고
    • Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
    • e1-4
    • Modica S, Petruzzelli M, Bellafante E et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 2012; 142: 355–365. e1-4.
    • (2012) Gastroenterology , vol.142 , pp. 355-365
    • Modica, S.1    Petruzzelli, M.2    Bellafante, E.3
  • 97
    • 84868360297 scopus 로고    scopus 로고
    • Perspective: TGR5 (Gpbar-1) in liver physiology and disease
    • Keitel V, Haussinger D. Perspective: TGR5 (Gpbar-1) in liver physiology and disease. Clin Res Hepatol Gastroenterol 2012; 36: 412–419.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , pp. 412-419
    • Keitel, V.1    Haussinger, D.2
  • 98
    • 84963852038 scopus 로고    scopus 로고
    • Characterization of intestinal microbiota in ulcerative colitis patients with and without primary sclerosing cholangitis
    • Kevans D, Tyler AD, Holm K et al. Characterization of intestinal microbiota in ulcerative colitis patients with and without primary sclerosing cholangitis. J Crohns Colitis 2016; 10: 330–337.
    • (2016) J Crohns Colitis , vol.10 , pp. 330-337
    • Kevans, D.1    Tyler, A.D.2    Holm, K.3
  • 99
    • 84959450854 scopus 로고    scopus 로고
    • The features of mucosa-associated microbiota in primary sclerosing cholangitis
    • Torres J, Bao X, Goel A et al. The features of mucosa-associated microbiota in primary sclerosing cholangitis. Aliment Pharmacol Ther 2016; 43: 790–801.
    • (2016) Aliment Pharmacol Ther , vol.43 , pp. 790-801
    • Torres, J.1    Bao, X.2    Goel, A.3
  • 100
    • 84959450356 scopus 로고    scopus 로고
    • The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
    • Kummen M, Holm K, Anmarkrud JA et al. The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut 2017; 66: 611–619.
    • (2017) Gut , vol.66 , pp. 611-619
    • Kummen, M.1    Holm, K.2    Anmarkrud, J.A.3
  • 101
    • 84970044586 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD
    • Sabino J, Vieira-Silva S, Machiels K et al. Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD. Gut 2016; 65: 1681–1689.
    • (2016) Gut , vol.65 , pp. 1681-1689
    • Sabino, J.1    Vieira-Silva, S.2    Machiels, K.3
  • 102
    • 85017020917 scopus 로고    scopus 로고
    • Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis
    • Ruhlemann MC, Heinsen FA, Zenouzi R, Lieb W, Franke A, Schramm C. Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis. Gut 2017; 66: 753–754.
    • (2017) Gut , vol.66 , pp. 753-754
    • Ruhlemann, M.C.1    Heinsen, F.A.2    Zenouzi, R.3    Lieb, W.4    Franke, A.5    Schramm, C.6
  • 103
    • 84964846111 scopus 로고    scopus 로고
    • The gut-adherent microbiota of PSC-IBD is distinct to that of IBD
    • Quraishi MN, Sergeant M, Kay G et al. The gut-adherent microbiota of PSC-IBD is distinct to that of IBD. Gut 2017; 66: 386–388.
    • (2017) Gut , vol.66 , pp. 386-388
    • Quraishi, M.N.1    Sergeant, M.2    Kay, G.3
  • 104
    • 84977664082 scopus 로고    scopus 로고
    • Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis
    • Lv LX, Fang DQ, Shi D et al. Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis. Environ Microbiol 2016; 18: 2272–2286.
    • (2016) Environ Microbiol , vol.18 , pp. 2272-2286
    • Lv, L.X.1    Fang, D.Q.2    Shi, D.3
  • 105
    • 85042885903 scopus 로고    scopus 로고
    • Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy
    • gutjnl-2016-313332
    • Tang R, Wei Y, Li Y et al. Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy. Gut 2017; gutjnl-2016-313332.
    • (2017) Gut
    • Tang, R.1    Wei, Y.2    Li, Y.3
  • 106
    • 79960714764 scopus 로고    scopus 로고
    • Characterization of fecal microbial communities in patients with liver cirrhosis
    • Chen Y, Yang F, Lu H et al. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 2011; 54: 562–572.
    • (2011) Hepatology , vol.54 , pp. 562-572
    • Chen, Y.1    Yang, F.2    Lu, H.3
  • 107
    • 84876294967 scopus 로고    scopus 로고
    • Modulation of the fecal bile acid profile by gut microbiota in cirrhosis
    • Kakiyama G, Pandak WM, Gillevet PM et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol 2013; 58: 949–955.
    • (2013) J Hepatol , vol.58 , pp. 949-955
    • Kakiyama, G.1    Pandak, W.M.2    Gillevet, P.M.3
  • 108
    • 76349105495 scopus 로고    scopus 로고
    • Intestinal permeability in cirrhotic patients with and without spontaneous bacterial peritonitis: is the ring closed?
    • Scarpellini E, Valenza V, Gabrielli M et al. Intestinal permeability in cirrhotic patients with and without spontaneous bacterial peritonitis: is the ring closed? Am J Gastroenterol 2010; 105: 323–327.
    • (2010) Am J Gastroenterol , vol.105 , pp. 323-327
    • Scarpellini, E.1    Valenza, V.2    Gabrielli, M.3
  • 109
    • 84866396844 scopus 로고    scopus 로고
    • Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
    • Bajaj JS, Hylemon PB, Ridlon JM et al. Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol 2012; 303: G675–G685.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , pp. G675-G685
    • Bajaj, J.S.1    Hylemon, P.B.2    Ridlon, J.M.3
  • 110
    • 84898830272 scopus 로고    scopus 로고
    • Altered profile of human gut microbiome is associated with cirrhosis and its complications
    • Bajaj JS, Heuman DM, Hylemon PB et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 2014; 60: 940–947.
    • (2014) J Hepatol , vol.60 , pp. 940-947
    • Bajaj, J.S.1    Heuman, D.M.2    Hylemon, P.B.3
  • 111
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • Qin N, Yang F, Li A et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 2014; 513: 59–64.
    • (2014) Nature , vol.513 , pp. 59-64
    • Qin, N.1    Yang, F.2    Li, A.3
  • 112
    • 79960695556 scopus 로고    scopus 로고
    • Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
    • Watanabe M, Horai Y, Houten SM et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem 2011; 286: 26913–26920.
    • (2011) J Biol Chem , vol.286 , pp. 26913-26920
    • Watanabe, M.1    Horai, Y.2    Houten, S.M.3
  • 113
    • 0037101810 scopus 로고    scopus 로고
    • 6α-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
    • Pellicciari R, Fiorucci S, Camaioni E et al. 6α-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 2002; 45: 3569–3572.
    • (2002) J Med Chem , vol.45 , pp. 3569-3572
    • Pellicciari, R.1    Fiorucci, S.2    Camaioni, E.3
  • 114
    • 84982102773 scopus 로고    scopus 로고
    • A placebo-controlled trial of obeticholic acid in primary biliary cholangitis
    • Nevens F, Andreone P, Mazzella G et al. A placebo-controlled trial of obeticholic acid in primary biliary cholangitis. N Engl J Med 2016; 375: 631–643.
    • (2016) N Engl J Med , vol.375 , pp. 631-643
    • Nevens, F.1    Andreone, P.2    Mazzella, G.3
  • 115
    • 85028654243 scopus 로고    scopus 로고
    • New developments in the treatment of primary biliary cholangitis – role of obeticholic acid
    • Jhaveri MA, Kowdley KV. New developments in the treatment of primary biliary cholangitis – role of obeticholic acid. Ther Clin Risk Manag 2017; 13: 1053–1060.
    • (2017) Ther Clin Risk Manag , vol.13 , pp. 1053-1060
    • Jhaveri, M.A.1    Kowdley, K.V.2
  • 116
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar S, Henry RR, Sanyal AJ et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574–82.e1.
    • (2013) Gastroenterology , vol.145 , pp. 574-82.e1
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3
  • 117
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri BA, Loomba R, Sanyal AJ et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 2015; 385: 956–965.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3
  • 118
    • 84963647487 scopus 로고    scopus 로고
    • Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats
    • Ubeda M, Lario M, Munoz L et al. Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats. J Hepatol 2016; 64: 1049–1057.
    • (2016) J Hepatol , vol.64 , pp. 1049-1057
    • Ubeda, M.1    Lario, M.2    Munoz, L.3
  • 119
    • 85019480553 scopus 로고    scopus 로고
    • Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
    • Zhou M, Yang H, Learned RM, Tian H, Ling L. Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis. Nat Commun 2017; 8: 15433.
    • (2017) Nat Commun , vol.8 , pp. 15433
    • Zhou, M.1    Yang, H.2    Learned, R.M.3    Tian, H.4    Ling, L.5
  • 120
    • 79960838523 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity
    • Prawitt J, Abdelkarim M, Stroeve JH et al. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 2011; 60: 1861–1871.
    • (2011) Diabetes , vol.60 , pp. 1861-1871
    • Prawitt, J.1    Abdelkarim, M.2    Stroeve, J.H.3
  • 121
    • 84949932843 scopus 로고    scopus 로고
    • Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
    • Jiang C, Xie C, Lv Y et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun 2015; 6: 10166.
    • (2015) Nat Commun , vol.6 , pp. 10166
    • Jiang, C.1    Xie, C.2    Lv, Y.3
  • 122
    • 84920401295 scopus 로고    scopus 로고
    • Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
    • Jiang C, Xie C, Li F et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest 2015; 125: 386–402.
    • (2015) J Clin Invest , vol.125 , pp. 386-402
    • Jiang, C.1    Xie, C.2    Li, F.3
  • 123
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-β-muricholic acid, a naturally occurring FXR antagonist
    • Sayin SI, Wahlstrom A, Felin J et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-β-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013; 17: 225–235.
    • (2013) Cell Metab , vol.17 , pp. 225-235
    • Sayin, S.I.1    Wahlstrom, A.2    Felin, J.3
  • 124
    • 84929607710 scopus 로고    scopus 로고
    • Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
    • Mueller M, Thorell A, Claudel T et al. Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. J Hepatol 2015; 62: 1398–1404.
    • (2015) J Hepatol , vol.62 , pp. 1398-1404
    • Mueller, M.1    Thorell, A.2    Claudel, T.3
  • 125
    • 84929606382 scopus 로고    scopus 로고
    • Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity
    • Gonzalez FJ, Jiang C, Bisson WH, Patterson AD. Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity. J Hepatol 2015; 62: 1234–1236.
    • (2015) J Hepatol , vol.62 , pp. 1234-1236
    • Gonzalez, F.J.1    Jiang, C.2    Bisson, W.H.3    Patterson, A.D.4
  • 126
    • 78651098672 scopus 로고    scopus 로고
    • Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators
    • Sharma R, Prichard D, Majer F et al. Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators. J Med Chem 2011; 54: 122–130.
    • (2011) J Med Chem , vol.54 , pp. 122-130
    • Sharma, R.1    Prichard, D.2    Majer, F.3


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