-
1
-
-
33244467651
-
Bile salt biotransformations by human intestinal bacteria
-
Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006; 47: 241–259.
-
(2006)
J Lipid Res
, vol.47
, pp. 241-259
-
-
Ridlon, J.M.1
Kang, D.J.2
Hylemon, P.B.3
-
2
-
-
0030773526
-
Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat
-
Vlahcevic ZR, Stravitz RT, Heuman DM, Hylemon PB, Pandak WM. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. Gastroenterology 1997; 113: 1949–1957.
-
(1997)
Gastroenterology
, vol.113
, pp. 1949-1957
-
-
Vlahcevic, Z.R.1
Stravitz, R.T.2
Heuman, D.M.3
Hylemon, P.B.4
Pandak, W.M.5
-
3
-
-
0032769064
-
27-Hydroxycholesterol: production rates in normal human subjects
-
Duane WC, Javitt NB. 27-Hydroxycholesterol: production rates in normal human subjects. J Lipid Res 1999; 40: 1194–1199.
-
(1999)
J Lipid Res
, vol.40
, pp. 1194-1199
-
-
Duane, W.C.1
Javitt, N.B.2
-
4
-
-
84951209574
-
Implications of microbiota and bile acid in liver injury and regeneration
-
Liu HX, Keane R, Sheng L, Wan YJ. Implications of microbiota and bile acid in liver injury and regeneration. J Hepatol 2015; 63: 1502–1510.
-
(2015)
J Hepatol
, vol.63
, pp. 1502-1510
-
-
Liu, H.X.1
Keane, R.2
Sheng, L.3
Wan, Y.J.4
-
5
-
-
85010383234
-
The ascending pathophysiology of cholestatic liver disease
-
Jansen PL, Ghallab A, Vartak N et al. The ascending pathophysiology of cholestatic liver disease. Hepatology 2017; 65: 722–738.
-
(2017)
Hepatology
, vol.65
, pp. 722-738
-
-
Jansen, P.L.1
Ghallab, A.2
Vartak, N.3
-
6
-
-
65649124573
-
Bile-acid-induced cell injury and protection
-
Perez MJ, Briz O. Bile-acid-induced cell injury and protection. World J Gastroenterol 2009; 15: 1677–1689.
-
(2009)
World J Gastroenterol
, vol.15
, pp. 1677-1689
-
-
Perez, M.J.1
Briz, O.2
-
7
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang H, Chen J, Hollister K, Sowers LC, Forman BM. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3: 543–553.
-
(1999)
Mol Cell
, vol.3
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
8
-
-
0037123667
-
Vitamin D receptor as an intestinal bile acid sensor
-
Makishima M, Lu TT, Xie W et al. Vitamin D receptor as an intestinal bile acid sensor. Science 2002; 296: 1313–1316.
-
(2002)
Science
, vol.296
, pp. 1313-1316
-
-
Makishima, M.1
Lu, T.T.2
Xie, W.3
-
9
-
-
0035853165
-
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
-
Staudinger JL, Goodwin B, Jones SA et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci USA 2001; 98: 3369–3374.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 3369-3374
-
-
Staudinger, J.L.1
Goodwin, B.2
Jones, S.A.3
-
10
-
-
0003269455
-
A G protein-coupled receptor responsive to bile acids
-
Kawamata Y, Fujii R, Hosoya M et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003; 278: 9435–9440.
-
(2003)
J Biol Chem
, vol.278
, pp. 9435-9440
-
-
Kawamata, Y.1
Fujii, R.2
Hosoya, M.3
-
11
-
-
84989244927
-
The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases
-
Nagahashi M, Yuza K, Hirose Y et al. The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. J Lipid Res 2016; 57: 1636–1643.
-
(2016)
J Lipid Res
, vol.57
, pp. 1636-1643
-
-
Nagahashi, M.1
Yuza, K.2
Hirose, Y.3
-
12
-
-
77958099262
-
Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes
-
Sheikh Abdul Kadir SH, Miragoli M, Abu-Hayyeh S et al. Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes. PLoS One 2010; 5: e9689.
-
(2010)
PLoS One
, vol.5
-
-
Sheikh Abdul Kadir, S.H.1
Miragoli, M.2
Abu-Hayyeh, S.3
-
13
-
-
58249110568
-
Role of bile acids and bile acid receptors in metabolic regulation
-
Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147–191.
-
(2009)
Physiol Rev
, vol.89
, pp. 147-191
-
-
Lefebvre, P.1
Cariou, B.2
Lien, F.3
Kuipers, F.4
Staels, B.5
-
14
-
-
84923031534
-
Nutrient-sensing nuclear receptors coordinate autophagy
-
Lee JM, Wagner M, Xiao R et al. Nutrient-sensing nuclear receptors coordinate autophagy. Nature 2014; 516: 112–115.
-
(2014)
Nature
, vol.516
, pp. 112-115
-
-
Lee, J.M.1
Wagner, M.2
Xiao, R.3
-
15
-
-
84922968506
-
Transcriptional regulation of autophagy by an FXR–CREB axis
-
Seok S, Fu T, Choi SE et al. Transcriptional regulation of autophagy by an FXR–CREB axis. Nature 2014; 516: 108–111.
-
(2014)
Nature
, vol.516
, pp. 108-111
-
-
Seok, S.1
Fu, T.2
Choi, S.E.3
-
16
-
-
85047694456
-
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
-
Watanabe M, Houten SM, Wang L et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 2004; 113: 1408–1418.
-
(2004)
J Clin Invest
, vol.113
, pp. 1408-1418
-
-
Watanabe, M.1
Houten, S.M.2
Wang, L.3
-
17
-
-
84923066154
-
FXR agonists as therapeutic agents for non-alcoholic fatty liver disease
-
Carr RM, Reid AE. FXR agonists as therapeutic agents for non-alcoholic fatty liver disease. Curr Atheroscler Rep 2015; 17: 500.
-
(2015)
Curr Atheroscler Rep
, vol.17
, pp. 500
-
-
Carr, R.M.1
Reid, A.E.2
-
18
-
-
84947201682
-
Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids
-
Ferrebee CB, Dawson PA. Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids. Acta Pharm Sin B 2015; 5: 129–134.
-
(2015)
Acta Pharm Sin B
, vol.5
, pp. 129-134
-
-
Ferrebee, C.B.1
Dawson, P.A.2
-
19
-
-
84949105963
-
Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease
-
Jahn D, Rau M, Hermanns HM, Geier A. Mechanisms of enterohepatic fibroblast growth factor 15/19 signaling in health and disease. Cytokine Growth Factor Rev 2015; 26: 625–635.
-
(2015)
Cytokine Growth Factor Rev
, vol.26
, pp. 625-635
-
-
Jahn, D.1
Rau, M.2
Hermanns, H.M.3
Geier, A.4
-
20
-
-
84958206076
-
Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease
-
Fuchs CD, Traussnigg SA, Trauner M. Nuclear receptor modulation for the treatment of nonalcoholic fatty liver disease. Semin Liver Dis 2016; 36: 69–86.
-
(2016)
Semin Liver Dis
, vol.36
, pp. 69-86
-
-
Fuchs, C.D.1
Traussnigg, S.A.2
Trauner, M.3
-
22
-
-
79959975693
-
Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults
-
Cariou B, Chetiveaux M, Zair Y et al. Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults. Nutr Metab (Lond) 2011; 8: 48.
-
(2011)
Nutr Metab (Lond)
, vol.8
, pp. 48
-
-
Cariou, B.1
Chetiveaux, M.2
Zair, Y.3
-
23
-
-
79956088562
-
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
-
Pols TW, Noriega LG, Nomura M, Auwerx J, Schoonjans K. The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J Hepatol 2011; 54: 1263–1272.
-
(2011)
J Hepatol
, vol.54
, pp. 1263-1272
-
-
Pols, T.W.1
Noriega, L.G.2
Nomura, M.3
Auwerx, J.4
Schoonjans, K.5
-
24
-
-
69149083245
-
TGR5-mediated bile acid sensing controls glucose homeostasis
-
Thomas C, Gioiello A, Noriega L et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 2009; 10: 167–177.
-
(2009)
Cell Metab
, vol.10
, pp. 167-177
-
-
Thomas, C.1
Gioiello, A.2
Noriega, L.3
-
25
-
-
31444454037
-
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
-
Watanabe M, Houten SM, Mataki C et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006; 439: 484–489.
-
(2006)
Nature
, vol.439
, pp. 484-489
-
-
Watanabe, M.1
Houten, S.M.2
Mataki, C.3
-
26
-
-
84940719531
-
The bile acid chenodeoxycholic acid increases human brown adipose tissue activity
-
Broeders EP, Nascimento EB, Havekes B et al. The bile acid chenodeoxycholic acid increases human brown adipose tissue activity. Cell Metab 2015; 22: 418–426.
-
(2015)
Cell Metab
, vol.22
, pp. 418-426
-
-
Broeders, E.P.1
Nascimento, E.B.2
Havekes, B.3
-
27
-
-
34248223285
-
Biology of incretins: GLP-1 and GIP
-
Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131–2157.
-
(2007)
Gastroenterology
, vol.132
, pp. 2131-2157
-
-
Baggio, L.L.1
Drucker, D.J.2
-
28
-
-
33750914846
-
Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level
-
Alarcon C, Wicksteed B, Rhodes CJ. Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level. Diabetologia 2006; 49: 2920–2929.
-
(2006)
Diabetologia
, vol.49
, pp. 2920-2929
-
-
Alarcon, C.1
Wicksteed, B.2
Rhodes, C.J.3
-
29
-
-
0033591387
-
Bile acids: natural ligands for an orphan nuclear receptor
-
Parks DJ, Blanchard SG, Bledsoe RK et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999; 284: 1365–1368.
-
(1999)
Science
, vol.284
, pp. 1365-1368
-
-
Parks, D.J.1
Blanchard, S.G.2
Bledsoe, R.K.3
-
30
-
-
84871124415
-
A metagenomic insight into our gut's microbiome
-
Lepage P, Leclerc MC, Joossens M et al. A metagenomic insight into our gut's microbiome. Gut 2013; 62: 146–158.
-
(2013)
Gut
, vol.62
, pp. 146-158
-
-
Lepage, P.1
Leclerc, M.C.2
Joossens, M.3
-
31
-
-
79251584066
-
Bifidobacteria can protect from enteropathogenic infection through production of acetate
-
Fukuda S, Toh H, Hase K et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 2011; 469: 543–547.
-
(2011)
Nature
, vol.469
, pp. 543-547
-
-
Fukuda, S.1
Toh, H.2
Hase, K.3
-
32
-
-
0028126829
-
The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations
-
Collins MD, Lawson PA, Willems A et al. The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations. Int J Syst Bacteriol 1994; 44: 812–826.
-
(1994)
Int J Syst Bacteriol
, vol.44
, pp. 812-826
-
-
Collins, M.D.1
Lawson, P.A.2
Willems, A.3
-
33
-
-
84941347610
-
Impact of commensal microbiota on the host pathophysiology: focusing on immunity and inflammation
-
Ohno H. Impact of commensal microbiota on the host pathophysiology: focusing on immunity and inflammation. Semin Immunopathol 2015; 37: 1–3.
-
(2015)
Semin Immunopathol
, vol.37
, pp. 1-3
-
-
Ohno, H.1
-
34
-
-
84867074831
-
A metagenome-wide association study of gut microbiota in type 2 diabetes
-
Qin J, Li Y, Cai Z et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012; 490: 55–60.
-
(2012)
Nature
, vol.490
, pp. 55-60
-
-
Qin, J.1
Li, Y.2
Cai, Z.3
-
35
-
-
84871814687
-
Symptomatic atherosclerosis is associated with an altered gut metagenome
-
Karlsson FH, Fak F, Nookaew I et al. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun 2012; 3: 1245.
-
(2012)
Nat Commun
, vol.3
, pp. 1245
-
-
Karlsson, F.H.1
Fak, F.2
Nookaew, I.3
-
36
-
-
84876563088
-
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
-
Tang WH, Wang Z, Levison BS et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 2013; 368: 1575–1584.
-
(2013)
N Engl J Med
, vol.368
, pp. 1575-1584
-
-
Tang, W.H.1
Wang, Z.2
Levison, B.S.3
-
37
-
-
58749112734
-
A core gut microbiome in obese and lean twins
-
Turnbaugh PJ, Hamady M, Yatsunenko T et al. A core gut microbiome in obese and lean twins. Nature 2009; 457: 480–484.
-
(2009)
Nature
, vol.457
, pp. 480-484
-
-
Turnbaugh, P.J.1
Hamady, M.2
Yatsunenko, T.3
-
38
-
-
84987602337
-
Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation
-
Fujimura KE, Sitarik AR, Havstad S et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med 2016; 22: 1187–1191.
-
(2016)
Nat Med
, vol.22
, pp. 1187-1191
-
-
Fujimura, K.E.1
Sitarik, A.R.2
Havstad, S.3
-
39
-
-
84894118144
-
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
-
Hsiao EY, McBride SW, Hsien S et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013; 155: 1451–1463.
-
(2013)
Cell
, vol.155
, pp. 1451-1463
-
-
Hsiao, E.Y.1
McBride, S.W.2
Hsien, S.3
-
40
-
-
84947447931
-
Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridia XIVa and IV clusters
-
Miyake S, Kim S, Suda W et al. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridia XIVa and IV clusters. PLoS One 2015; 10: e0137429.
-
(2015)
PLoS One
, vol.10
-
-
Miyake, S.1
Kim, S.2
Suda, W.3
-
41
-
-
84951284320
-
Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson's disease
-
Hasegawa S, Goto S, Tsuji H et al. Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson's disease. PLoS One 2015; 10: e0142164.
-
(2015)
PLoS One
, vol.10
-
-
Hasegawa, S.1
Goto, S.2
Tsuji, H.3
-
42
-
-
84879604697
-
Intestinal microbiota in patients with nonalcoholic fatty liver disease
-
Mouzaki M, Comelli EM, Arendt BM et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology 2013; 58: 120–127.
-
(2013)
Hepatology
, vol.58
, pp. 120-127
-
-
Mouzaki, M.1
Comelli, E.M.2
Arendt, B.M.3
-
43
-
-
84954288595
-
The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota
-
Boursier J, Mueller O, Barret M et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology 2016; 63: 764–775.
-
(2016)
Hepatology
, vol.63
, pp. 764-775
-
-
Boursier, J.1
Mueller, O.2
Barret, M.3
-
44
-
-
84879888338
-
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
-
Yoshimoto S, Loo TM, Atarashi K et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013; 499: 97–101.
-
(2013)
Nature
, vol.499
, pp. 97-101
-
-
Yoshimoto, S.1
Loo, T.M.2
Atarashi, K.3
-
45
-
-
84925486076
-
The gut microbiota and inflammatory bowel disease
-
Matsuoka K, Kanai T. The gut microbiota and inflammatory bowel disease. Semin Immunopathol 2015; 37: 47–55.
-
(2015)
Semin Immunopathol
, vol.37
, pp. 47-55
-
-
Matsuoka, K.1
Kanai, T.2
-
46
-
-
57649179488
-
Faecal microbiota profile of Crohn's disease determined by terminal restriction fragment length polymorphism analysis
-
Andoh A, Tsujikawa T, Sasaki M et al. Faecal microbiota profile of Crohn's disease determined by terminal restriction fragment length polymorphism analysis. Aliment Pharmacol Ther 2009; 29: 75–82.
-
(2009)
Aliment Pharmacol Ther
, vol.29
, pp. 75-82
-
-
Andoh, A.1
Tsujikawa, T.2
Sasaki, M.3
-
47
-
-
79953748870
-
Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
-
Joossens M, Huys G, Cnockaert M et al. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut 2011; 60: 631–637.
-
(2011)
Gut
, vol.60
, pp. 631-637
-
-
Joossens, M.1
Huys, G.2
Cnockaert, M.3
-
48
-
-
84871530893
-
Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis
-
Nemoto H, Kataoka K, Ishikawa H et al. Reduced diversity and imbalance of fecal microbiota in patients with ulcerative colitis. Dig Dis Sci 2012; 57: 2955–2964.
-
(2012)
Dig Dis Sci
, vol.57
, pp. 2955-2964
-
-
Nemoto, H.1
Kataoka, K.2
Ishikawa, H.3
-
49
-
-
84931423571
-
Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis
-
Rossen NG, Fuentes S, van der Spek MJ et al. Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 2015; 149: 110–8.e4.
-
(2015)
Gastroenterology
, vol.149
, pp. 110-8.e4
-
-
Rossen, N.G.1
Fuentes, S.2
van der Spek, M.J.3
-
50
-
-
34447104397
-
The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects
-
Kassinen A, Krogius-Kurikka L, Makivuokko H et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 2007; 133: 24–33.
-
(2007)
Gastroenterology
, vol.133
, pp. 24-33
-
-
Kassinen, A.1
Krogius-Kurikka, L.2
Makivuokko, H.3
-
51
-
-
85005965070
-
The human intestinal microbiome in health and disease
-
Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med 2016; 375: 2369–2379.
-
(2016)
N Engl J Med
, vol.375
, pp. 2369-2379
-
-
Lynch, S.V.1
Pedersen, O.2
-
53
-
-
84866168894
-
Functional interactions between the gut microbiota and host metabolism
-
Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012; 489: 242–249.
-
(2012)
Nature
, vol.489
, pp. 242-249
-
-
Tremaroli, V.1
Backhed, F.2
-
54
-
-
85014611332
-
Disease-associated changes in bile acid profiles and links to altered gut microbiota
-
Joyce SA, Gahan CG. Disease-associated changes in bile acid profiles and links to altered gut microbiota. Dig Dis 2017; 35: 169–177.
-
(2017)
Dig Dis
, vol.35
, pp. 169-177
-
-
Joyce, S.A.1
Gahan, C.G.2
-
55
-
-
84901020405
-
Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
-
Joyce SA, MacSharry J, Casey PG et al. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci USA 2014; 111: 7421–7426.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 7421-7426
-
-
Joyce, S.A.1
MacSharry, J.2
Casey, P.G.3
-
56
-
-
84922021716
-
Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe–host crosstalk
-
Joyce SA, Shanahan F, Hill C, Gahan CG. Bacterial bile salt hydrolase in host metabolism: potential for influencing gastrointestinal microbe–host crosstalk. Gut Microbes 2014; 5: 669–674.
-
(2014)
Gut Microbes
, vol.5
, pp. 669-674
-
-
Joyce, S.A.1
Shanahan, F.2
Hill, C.3
Gahan, C.G.4
-
57
-
-
0029041833
-
Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens
-
Coleman JP, Hudson LL. Cloning and characterization of a conjugated bile acid hydrolase gene from Clostridium perfringens. Appl Environ Microbiol 1995; 61: 2514–2520.
-
(1995)
Appl Environ Microbiol
, vol.61
, pp. 2514-2520
-
-
Coleman, J.P.1
Hudson, L.L.2
-
58
-
-
0026446050
-
Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay
-
Christiaens H, Leer RJ, Pouwels PH, Verstraete W. Cloning and expression of a conjugated bile acid hydrolase gene from Lactobacillus plantarum by using a direct plate assay. Appl Environ Microbiol 1992; 58: 3792–3798.
-
(1992)
Appl Environ Microbiol
, vol.58
, pp. 3792-3798
-
-
Christiaens, H.1
Leer, R.J.2
Pouwels, P.H.3
Verstraete, W.4
-
59
-
-
0031720810
-
Identification of genes encoding conjugated bile salt hydrolase and transport in Lactobacillus johnsonii 100-100
-
Elkins CA, Savage DC. Identification of genes encoding conjugated bile salt hydrolase and transport in Lactobacillus johnsonii 100-100. J Bacteriol 1998; 180: 4344–4349.
-
(1998)
J Bacteriol
, vol.180
, pp. 4344-4349
-
-
Elkins, C.A.1
Savage, D.C.2
-
60
-
-
0034048222
-
Bile salt hydrolase of Bifidobacterium longum –biochemical and genetic characterization
-
Tanaka H, Hashiba H, Kok J, Mierau I. Bile salt hydrolase of Bifidobacterium longum –biochemical and genetic characterization. Appl Environ Microbiol 2000; 66: 2502–2512.
-
(2000)
Appl Environ Microbiol
, vol.66
, pp. 2502-2512
-
-
Tanaka, H.1
Hashiba, H.2
Kok, J.3
Mierau, I.4
-
61
-
-
0024058679
-
Purification and characterization of bile salt hydrolase from Clostridium perfringens
-
Gopal-Srivastava R, Hylemon PB. Purification and characterization of bile salt hydrolase from Clostridium perfringens. J Lipid Res 1988; 29: 1079–1085.
-
(1988)
J Lipid Res
, vol.29
, pp. 1079-1085
-
-
Gopal-Srivastava, R.1
Hylemon, P.B.2
-
62
-
-
0018332888
-
7α-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum
-
Stellwag EJ, Hylemon PB. 7α-Dehydroxylation of cholic acid and chenodeoxycholic acid by Clostridium leptum. J Lipid Res 1979; 20: 325–333.
-
(1979)
J Lipid Res
, vol.20
, pp. 325-333
-
-
Stellwag, E.J.1
Hylemon, P.B.2
-
63
-
-
0035155058
-
Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7α-dehydroxylating activity
-
Kitahara M, Takamine F, Imamura T, Benno Y. Clostridium hiranonis sp. nov., a human intestinal bacterium with bile acid 7α-dehydroxylating activity. Int J Syst Evol Microbiol 2001; 51: 39–44.
-
(2001)
Int J Syst Evol Microbiol
, vol.51
, pp. 39-44
-
-
Kitahara, M.1
Takamine, F.2
Imamura, T.3
Benno, Y.4
-
64
-
-
0034034841
-
Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7α-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces
-
Kitahara M, Takamine F, Imamura T, Benno Y. Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7α-dehydroxylating activity to Clostridium scindens and proposal of Clostridium hylemonae sp. nov., isolated from human faeces. Int J Syst Evol Microbiol 2000; 50(Pt 3): 971–978.
-
(2000)
Int J Syst Evol Microbiol
, vol.50
, pp. 971-978
-
-
Kitahara, M.1
Takamine, F.2
Imamura, T.3
Benno, Y.4
-
65
-
-
84883442887
-
Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship
-
Ridlon JM, Alves JM, Hylemon PB, Bajaj JS. Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship. Gut Microbes 2013; 4: 382–387.
-
(2013)
Gut Microbes
, vol.4
, pp. 382-387
-
-
Ridlon, J.M.1
Alves, J.M.2
Hylemon, P.B.3
Bajaj, J.S.4
-
67
-
-
80054862011
-
Bile acid is a host factor that regulates the composition of the cecal microbiota in rats
-
Islam KB, Fukiya S, Hagio M et al. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 2011; 141: 1773–1781.
-
(2011)
Gastroenterology
, vol.141
, pp. 1773-1781
-
-
Islam, K.B.1
Fukiya, S.2
Hagio, M.3
-
68
-
-
84866040724
-
Is bile acid a determinant of the gut microbiota on a high-fat diet?
-
Yokota A, Fukiya S, Islam KB et al. Is bile acid a determinant of the gut microbiota on a high-fat diet? Gut Microbes 2012; 3: 455–459.
-
(2012)
Gut Microbes
, vol.3
, pp. 455-459
-
-
Yokota, A.1
Fukiya, S.2
Islam, K.B.3
-
69
-
-
85021078907
-
Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents
-
Watanabe M, Fukiya S, Yokota A. Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents. J Lipid Res 2017; 58: 1143–1152.
-
(2017)
J Lipid Res
, vol.58
, pp. 1143-1152
-
-
Watanabe, M.1
Fukiya, S.2
Yokota, A.3
-
70
-
-
85040102149
-
Detection of gut dysbiosis due to reduced Clostridium subcluster XIVa by based on the serum bile acid profile
-
(in press)
-
Murakami M, Iwamoto J, Miyazaki T et al. Detection of gut dysbiosis due to reduced Clostridium subcluster XIVa by based on the serum bile acid profile. Inflamm Bowel Dis (in press).
-
Inflamm Bowel Dis
-
-
Murakami, M.1
Iwamoto, J.2
Miyazaki, T.3
-
71
-
-
84938057875
-
Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease
-
Angulo P, Kleiner DE, Dam-Larsen S et al. Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease. Gastroenterology 2015; 149: 389–97.e10.
-
(2015)
Gastroenterology
, vol.149
, pp. 389-97.e10
-
-
Angulo, P.1
Kleiner, D.E.2
Dam-Larsen, S.3
-
72
-
-
84955267511
-
Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies
-
Musso G, Cassader M, Gambino R. Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies. Nat Rev Drug Discov 2016; 15: 249–274.
-
(2016)
Nat Rev Drug Discov
, vol.15
, pp. 249-274
-
-
Musso, G.1
Cassader, M.2
Gambino, R.3
-
73
-
-
84887477319
-
Bile acid receptors in non-alcoholic fatty liver disease
-
Li Y, Jadhav K, Zhang Y. Bile acid receptors in non-alcoholic fatty liver disease. Biochem Pharmacol 2013; 86: 1517–1524.
-
(2013)
Biochem Pharmacol
, vol.86
, pp. 1517-1524
-
-
Li, Y.1
Jadhav, K.2
Zhang, Y.3
-
75
-
-
84941918492
-
The gut microbiota and nonalcoholic fatty liver disease
-
Quigley EM, Monsour HP. The gut microbiota and nonalcoholic fatty liver disease. Semin Liver Dis 2015; 35: 262–269.
-
(2015)
Semin Liver Dis
, vol.35
, pp. 262-269
-
-
Quigley, E.M.1
Monsour, H.P.2
-
76
-
-
84951843544
-
Nonalcoholic fatty liver disease and the gut microbiome
-
Boursier J, Diehl AM. Nonalcoholic fatty liver disease and the gut microbiome. Clin Liver Dis 2016; 20: 263–275.
-
(2016)
Clin Liver Dis
, vol.20
, pp. 263-275
-
-
Boursier, J.1
Diehl, A.M.2
-
77
-
-
84930583108
-
Bile acid signaling: mechanism for bariatric surgery, cure for NASH?
-
Kohli R, Myronovych A, Tan BK et al. Bile acid signaling: mechanism for bariatric surgery, cure for NASH? Dig Dis 2015; 33: 440–446.
-
(2015)
Dig Dis
, vol.33
, pp. 440-446
-
-
Kohli, R.1
Myronovych, A.2
Tan, B.K.3
-
79
-
-
84945465558
-
Altered bile acid metabolome in patients with nonalcoholic steatohepatitis
-
Ferslew BC, Xie G, Johnston CK et al. Altered bile acid metabolome in patients with nonalcoholic steatohepatitis. Dig Dis Sci 2015; 60: 3318–3328.
-
(2015)
Dig Dis Sci
, vol.60
, pp. 3318-3328
-
-
Ferslew, B.C.1
Xie, G.2
Johnston, C.K.3
-
80
-
-
43449094989
-
Bile acid levels are increased in the liver of patients with steatohepatitis
-
Aranha MM, Cortez-Pinto H, Costa A et al. Bile acid levels are increased in the liver of patients with steatohepatitis. Eur J Gastroenterol Hepatol 2008; 20: 519–525.
-
(2008)
Eur J Gastroenterol Hepatol
, vol.20
, pp. 519-525
-
-
Aranha, M.M.1
Cortez-Pinto, H.2
Costa, A.3
-
81
-
-
79951792246
-
Plasma metabolomic profile in nonalcoholic fatty liver disease
-
Kalhan SC, Guo L, Edmison J et al. Plasma metabolomic profile in nonalcoholic fatty liver disease. Metabolism 2011; 60: 404–413.
-
(2011)
Metabolism
, vol.60
, pp. 404-413
-
-
Kalhan, S.C.1
Guo, L.2
Edmison, J.3
-
82
-
-
84991519034
-
Bile acids and dysbiosis in non-alcoholic fatty liver disease
-
Mouzaki M, Wang AY, Bandsma R et al. Bile acids and dysbiosis in non-alcoholic fatty liver disease. PLoS One 2016; 11: e0151829.
-
(2016)
PLoS One
, vol.11
-
-
Mouzaki, M.1
Wang, A.Y.2
Bandsma, R.3
-
83
-
-
85048040313
-
Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD
-
gutjnl-2017-314307
-
Jiao N, Baker SS, Chapa-Rodriguez A et al. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut 2017; gutjnl-2017-314307.
-
(2017)
Gut
-
-
Jiao, N.1
Baker, S.S.2
Chapa-Rodriguez, A.3
-
84
-
-
84884414277
-
Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
-
Le Roy T, Llopis M, Lepage P et al. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut 2013; 62: 1787–1794.
-
(2013)
Gut
, vol.62
, pp. 1787-1794
-
-
Le Roy, T.1
Llopis, M.2
Lepage, P.3
-
85
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
Henao-Mejia J, Elinav E, Jin C et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482: 179–185.
-
(2012)
Nature
, vol.482
, pp. 179-185
-
-
Henao-Mejia, J.1
Elinav, E.2
Jin, C.3
-
86
-
-
84899474318
-
Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice
-
De Minicis S, Rychlicki C, Agostinelli L et al. Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice. Hepatology 2014; 59: 1738–1749.
-
(2014)
Hepatology
, vol.59
, pp. 1738-1749
-
-
De Minicis, S.1
Rychlicki, C.2
Agostinelli, L.3
-
87
-
-
85018954191
-
Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease
-
Loomba R, Seguritan V, Li W et al. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 2017; 25: 1054–62.e5.
-
(2017)
Cell Metab
, vol.25
, pp. 1054-62.e5
-
-
Loomba, R.1
Seguritan, V.2
Li, W.3
-
88
-
-
85016485058
-
Finding the cure for primary biliary cholangitis – still waiting
-
Tanaka A, Gershwin ME. Finding the cure for primary biliary cholangitis – still waiting. Liver Int 2017; 37: 500–502.
-
(2017)
Liver Int
, vol.37
, pp. 500-502
-
-
Tanaka, A.1
Gershwin, M.E.2
-
89
-
-
84958161655
-
Primary biliary cirrhosis beyond ursodeoxycholic acid
-
Corpechot C. Primary biliary cirrhosis beyond ursodeoxycholic acid. Semin Liver Dis 2016; 36: 15–26.
-
(2016)
Semin Liver Dis
, vol.36
, pp. 15-26
-
-
Corpechot, C.1
-
90
-
-
84958182341
-
New therapeutic strategies for primary sclerosing cholangitis
-
Williamson KD, Chapman RW. New therapeutic strategies for primary sclerosing cholangitis. Semin Liver Dis 2016; 36: 5–14.
-
(2016)
Semin Liver Dis
, vol.36
, pp. 5-14
-
-
Williamson, K.D.1
Chapman, R.W.2
-
91
-
-
84953449930
-
A review of the medical treatment of primary sclerosing cholangitis in the 21st century
-
Goode EC, Rushbrook SM. A review of the medical treatment of primary sclerosing cholangitis in the 21st century. Ther Adv Chronic Dis 2016; 7: 68–85.
-
(2016)
Ther Adv Chronic Dis
, vol.7
, pp. 68-85
-
-
Goode, E.C.1
Rushbrook, S.M.2
-
92
-
-
85025127280
-
Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases
-
Li Y, Tang R, Leung PSC, Gershwin ME, Ma X. Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases. Autoimmun Rev 2017; 16: 885–896.
-
(2017)
Autoimmun Rev
, vol.16
, pp. 885-896
-
-
Li, Y.1
Tang, R.2
Leung, P.S.C.3
Gershwin, M.E.4
Ma, X.5
-
93
-
-
84995579603
-
Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis
-
Hisamoto S, Shimoda S, Harada K et al. Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis. J Autoimmun 2016; 75: 150–160.
-
(2016)
J Autoimmun
, vol.75
, pp. 150-160
-
-
Hisamoto, S.1
Shimoda, S.2
Harada, K.3
-
94
-
-
33744945790
-
Biliary obstruction selectively expands and activates liver myeloid dendritic cells
-
Bleier JI, Katz SC, Chaudhry UI et al. Biliary obstruction selectively expands and activates liver myeloid dendritic cells. J Immunol 2006; 176: 7189–7195.
-
(2006)
J Immunol
, vol.176
, pp. 7189-7195
-
-
Bleier, J.I.1
Katz, S.C.2
Chaudhry, U.I.3
-
96
-
-
84856159269
-
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
-
e1-4
-
Modica S, Petruzzelli M, Bellafante E et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 2012; 142: 355–365. e1-4.
-
(2012)
Gastroenterology
, vol.142
, pp. 355-365
-
-
Modica, S.1
Petruzzelli, M.2
Bellafante, E.3
-
97
-
-
84868360297
-
Perspective: TGR5 (Gpbar-1) in liver physiology and disease
-
Keitel V, Haussinger D. Perspective: TGR5 (Gpbar-1) in liver physiology and disease. Clin Res Hepatol Gastroenterol 2012; 36: 412–419.
-
(2012)
Clin Res Hepatol Gastroenterol
, vol.36
, pp. 412-419
-
-
Keitel, V.1
Haussinger, D.2
-
98
-
-
84963852038
-
Characterization of intestinal microbiota in ulcerative colitis patients with and without primary sclerosing cholangitis
-
Kevans D, Tyler AD, Holm K et al. Characterization of intestinal microbiota in ulcerative colitis patients with and without primary sclerosing cholangitis. J Crohns Colitis 2016; 10: 330–337.
-
(2016)
J Crohns Colitis
, vol.10
, pp. 330-337
-
-
Kevans, D.1
Tyler, A.D.2
Holm, K.3
-
99
-
-
84959450854
-
The features of mucosa-associated microbiota in primary sclerosing cholangitis
-
Torres J, Bao X, Goel A et al. The features of mucosa-associated microbiota in primary sclerosing cholangitis. Aliment Pharmacol Ther 2016; 43: 790–801.
-
(2016)
Aliment Pharmacol Ther
, vol.43
, pp. 790-801
-
-
Torres, J.1
Bao, X.2
Goel, A.3
-
100
-
-
84959450356
-
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
-
Kummen M, Holm K, Anmarkrud JA et al. The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut 2017; 66: 611–619.
-
(2017)
Gut
, vol.66
, pp. 611-619
-
-
Kummen, M.1
Holm, K.2
Anmarkrud, J.A.3
-
101
-
-
84970044586
-
Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD
-
Sabino J, Vieira-Silva S, Machiels K et al. Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD. Gut 2016; 65: 1681–1689.
-
(2016)
Gut
, vol.65
, pp. 1681-1689
-
-
Sabino, J.1
Vieira-Silva, S.2
Machiels, K.3
-
102
-
-
85017020917
-
Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis
-
Ruhlemann MC, Heinsen FA, Zenouzi R, Lieb W, Franke A, Schramm C. Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis. Gut 2017; 66: 753–754.
-
(2017)
Gut
, vol.66
, pp. 753-754
-
-
Ruhlemann, M.C.1
Heinsen, F.A.2
Zenouzi, R.3
Lieb, W.4
Franke, A.5
Schramm, C.6
-
103
-
-
84964846111
-
The gut-adherent microbiota of PSC-IBD is distinct to that of IBD
-
Quraishi MN, Sergeant M, Kay G et al. The gut-adherent microbiota of PSC-IBD is distinct to that of IBD. Gut 2017; 66: 386–388.
-
(2017)
Gut
, vol.66
, pp. 386-388
-
-
Quraishi, M.N.1
Sergeant, M.2
Kay, G.3
-
104
-
-
84977664082
-
Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis
-
Lv LX, Fang DQ, Shi D et al. Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis. Environ Microbiol 2016; 18: 2272–2286.
-
(2016)
Environ Microbiol
, vol.18
, pp. 2272-2286
-
-
Lv, L.X.1
Fang, D.Q.2
Shi, D.3
-
105
-
-
85042885903
-
Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy
-
gutjnl-2016-313332
-
Tang R, Wei Y, Li Y et al. Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy. Gut 2017; gutjnl-2016-313332.
-
(2017)
Gut
-
-
Tang, R.1
Wei, Y.2
Li, Y.3
-
106
-
-
79960714764
-
Characterization of fecal microbial communities in patients with liver cirrhosis
-
Chen Y, Yang F, Lu H et al. Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 2011; 54: 562–572.
-
(2011)
Hepatology
, vol.54
, pp. 562-572
-
-
Chen, Y.1
Yang, F.2
Lu, H.3
-
107
-
-
84876294967
-
Modulation of the fecal bile acid profile by gut microbiota in cirrhosis
-
Kakiyama G, Pandak WM, Gillevet PM et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol 2013; 58: 949–955.
-
(2013)
J Hepatol
, vol.58
, pp. 949-955
-
-
Kakiyama, G.1
Pandak, W.M.2
Gillevet, P.M.3
-
108
-
-
76349105495
-
Intestinal permeability in cirrhotic patients with and without spontaneous bacterial peritonitis: is the ring closed?
-
Scarpellini E, Valenza V, Gabrielli M et al. Intestinal permeability in cirrhotic patients with and without spontaneous bacterial peritonitis: is the ring closed? Am J Gastroenterol 2010; 105: 323–327.
-
(2010)
Am J Gastroenterol
, vol.105
, pp. 323-327
-
-
Scarpellini, E.1
Valenza, V.2
Gabrielli, M.3
-
109
-
-
84866396844
-
Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
-
Bajaj JS, Hylemon PB, Ridlon JM et al. Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation. Am J Physiol Gastrointest Liver Physiol 2012; 303: G675–G685.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.303
, pp. G675-G685
-
-
Bajaj, J.S.1
Hylemon, P.B.2
Ridlon, J.M.3
-
110
-
-
84898830272
-
Altered profile of human gut microbiome is associated with cirrhosis and its complications
-
Bajaj JS, Heuman DM, Hylemon PB et al. Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 2014; 60: 940–947.
-
(2014)
J Hepatol
, vol.60
, pp. 940-947
-
-
Bajaj, J.S.1
Heuman, D.M.2
Hylemon, P.B.3
-
111
-
-
84907225684
-
Alterations of the human gut microbiome in liver cirrhosis
-
Qin N, Yang F, Li A et al. Alterations of the human gut microbiome in liver cirrhosis. Nature 2014; 513: 59–64.
-
(2014)
Nature
, vol.513
, pp. 59-64
-
-
Qin, N.1
Yang, F.2
Li, A.3
-
112
-
-
79960695556
-
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
-
Watanabe M, Horai Y, Houten SM et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem 2011; 286: 26913–26920.
-
(2011)
J Biol Chem
, vol.286
, pp. 26913-26920
-
-
Watanabe, M.1
Horai, Y.2
Houten, S.M.3
-
113
-
-
0037101810
-
6α-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
-
Pellicciari R, Fiorucci S, Camaioni E et al. 6α-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 2002; 45: 3569–3572.
-
(2002)
J Med Chem
, vol.45
, pp. 3569-3572
-
-
Pellicciari, R.1
Fiorucci, S.2
Camaioni, E.3
-
114
-
-
84982102773
-
A placebo-controlled trial of obeticholic acid in primary biliary cholangitis
-
Nevens F, Andreone P, Mazzella G et al. A placebo-controlled trial of obeticholic acid in primary biliary cholangitis. N Engl J Med 2016; 375: 631–643.
-
(2016)
N Engl J Med
, vol.375
, pp. 631-643
-
-
Nevens, F.1
Andreone, P.2
Mazzella, G.3
-
115
-
-
85028654243
-
New developments in the treatment of primary biliary cholangitis – role of obeticholic acid
-
Jhaveri MA, Kowdley KV. New developments in the treatment of primary biliary cholangitis – role of obeticholic acid. Ther Clin Risk Manag 2017; 13: 1053–1060.
-
(2017)
Ther Clin Risk Manag
, vol.13
, pp. 1053-1060
-
-
Jhaveri, M.A.1
Kowdley, K.V.2
-
116
-
-
84880664792
-
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
-
Mudaliar S, Henry RR, Sanyal AJ et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574–82.e1.
-
(2013)
Gastroenterology
, vol.145
, pp. 574-82.e1
-
-
Mudaliar, S.1
Henry, R.R.2
Sanyal, A.J.3
-
117
-
-
84929266699
-
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
-
Neuschwander-Tetri BA, Loomba R, Sanyal AJ et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 2015; 385: 956–965.
-
(2015)
Lancet
, vol.385
, pp. 956-965
-
-
Neuschwander-Tetri, B.A.1
Loomba, R.2
Sanyal, A.J.3
-
118
-
-
84963647487
-
Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats
-
Ubeda M, Lario M, Munoz L et al. Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats. J Hepatol 2016; 64: 1049–1057.
-
(2016)
J Hepatol
, vol.64
, pp. 1049-1057
-
-
Ubeda, M.1
Lario, M.2
Munoz, L.3
-
119
-
-
85019480553
-
Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis
-
Zhou M, Yang H, Learned RM, Tian H, Ling L. Non-cell-autonomous activation of IL-6/STAT3 signaling mediates FGF19-driven hepatocarcinogenesis. Nat Commun 2017; 8: 15433.
-
(2017)
Nat Commun
, vol.8
, pp. 15433
-
-
Zhou, M.1
Yang, H.2
Learned, R.M.3
Tian, H.4
Ling, L.5
-
120
-
-
79960838523
-
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity
-
Prawitt J, Abdelkarim M, Stroeve JH et al. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 2011; 60: 1861–1871.
-
(2011)
Diabetes
, vol.60
, pp. 1861-1871
-
-
Prawitt, J.1
Abdelkarim, M.2
Stroeve, J.H.3
-
121
-
-
84949932843
-
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
-
Jiang C, Xie C, Lv Y et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun 2015; 6: 10166.
-
(2015)
Nat Commun
, vol.6
, pp. 10166
-
-
Jiang, C.1
Xie, C.2
Lv, Y.3
-
122
-
-
84920401295
-
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
-
Jiang C, Xie C, Li F et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest 2015; 125: 386–402.
-
(2015)
J Clin Invest
, vol.125
, pp. 386-402
-
-
Jiang, C.1
Xie, C.2
Li, F.3
-
123
-
-
84873342775
-
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-β-muricholic acid, a naturally occurring FXR antagonist
-
Sayin SI, Wahlstrom A, Felin J et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-β-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013; 17: 225–235.
-
(2013)
Cell Metab
, vol.17
, pp. 225-235
-
-
Sayin, S.I.1
Wahlstrom, A.2
Felin, J.3
-
124
-
-
84929607710
-
Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
-
Mueller M, Thorell A, Claudel T et al. Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. J Hepatol 2015; 62: 1398–1404.
-
(2015)
J Hepatol
, vol.62
, pp. 1398-1404
-
-
Mueller, M.1
Thorell, A.2
Claudel, T.3
-
125
-
-
84929606382
-
Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity
-
Gonzalez FJ, Jiang C, Bisson WH, Patterson AD. Inhibition of farnesoid X receptor signaling shows beneficial effects in human obesity. J Hepatol 2015; 62: 1234–1236.
-
(2015)
J Hepatol
, vol.62
, pp. 1234-1236
-
-
Gonzalez, F.J.1
Jiang, C.2
Bisson, W.H.3
Patterson, A.D.4
-
126
-
-
78651098672
-
Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators
-
Sharma R, Prichard D, Majer F et al. Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators. J Med Chem 2011; 54: 122–130.
-
(2011)
J Med Chem
, vol.54
, pp. 122-130
-
-
Sharma, R.1
Prichard, D.2
Majer, F.3
|