-
1
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine, B. & Klionsky, D. J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477 (2004).
-
(2004)
Dev. Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
2
-
-
78649704325
-
Autophagy andmetabolism
-
Rabinowitz, J. D.&White, E. Autophagy andmetabolism. Science 330, 1344-1348 (2010).
-
(2010)
Science
, vol.330
, pp. 1344-1348
-
-
Rabinowitz, J.D.1
White, E.2
-
3
-
-
48249140220
-
Diurnal rhythmsof autophagy: Implications for cell biology and human disease
-
Sachdeva, U. M.&Thompson, C. B. Diurnal rhythmsof autophagy: implications for cell biology and human disease. Autophagy 4, 581-589 (2008).
-
(2008)
Autophagy
, vol.4
, pp. 581-589
-
-
Sachdeva, U.M.1
Thompson, C.B.2
-
4
-
-
72949111893
-
Physiological functions of autophagy
-
Mizushima, N. Physiological functions of autophagy. Curr. Top. Microbiol. Immunol. 335, 71-84 (2009).
-
(2009)
Curr. Top. Microbiol. Immunol.
, vol.335
, pp. 71-84
-
-
Mizushima, N.1
-
5
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim, J., Kundu, M., Viollet, B. & Guan, K. L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature Cell Biol. 13, 132-141 (2011).
-
(2011)
Nature Cell Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
6
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan, D. F. et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331, 456-461 (2011).
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
-
7
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
He, C. & Klionsky, D. J. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43, 67-93 (2009).
-
(2009)
Annu. Rev. Genet.
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.J.2
-
8
-
-
84858796689
-
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
-
Calkin, A. C. & Tontonoz, P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nature Rev. Mol. Cell Biol. 13, 213-224 (2012).
-
(2012)
Nature Rev. Mol. Cell Biol.
, vol.13
, pp. 213-224
-
-
Calkin, A.C.1
Tontonoz, P.2
-
9
-
-
48749113401
-
Targeting bileacid signalling formetabolic diseases
-
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J.&Schoonjans, K. Targeting bileacid signalling formetabolic diseases.NatureRev. Drug Discov. 7,678-693(2008).
-
(2008)
NatureRev. Drug Discov.
, vol.7
, pp. 678-693
-
-
Thomas, C.1
Pellicciari, R.2
Pruzanski, M.3
Auwerx, J.4
Schoonjans, K.5
-
10
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo, S. H. et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437, 1109-1111 (2005).
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.H.1
-
11
-
-
67749135249
-
TheCREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
-
Wang, Y., Vera, L., Fischer, W. H.& Montminy, M. TheCREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537 (2009).
-
(2009)
Nature
, vol.460
, pp. 534-537
-
-
Wang, Y.1
Vera, L.2
Fischer, W.H.3
Montminy, M.4
-
12
-
-
84863512181
-
Genomic analysis of hepatic farnesoid X receptor (FXR) binding sites reveals altered binding in obesity and direct gene repression by FXR
-
Lee, J. et al. Genomic analysis of hepatic farnesoid X receptor (FXR) binding sites reveals altered binding in obesity and direct gene repression by FXR. Hepatology 56, 108-117 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 108-117
-
-
Lee, J.1
-
13
-
-
77950605769
-
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine
-
Thomas, A. M. et al. Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology 51, 1410-1419 (2010).
-
(2010)
Hepatology
, vol.51
, pp. 1410-1419
-
-
Thomas, A.M.1
-
14
-
-
84877811076
-
Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver
-
Everett, L. J. et al. Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. BMC Genomics 14, 337 (2013).
-
(2013)
BMC Genomics
, vol.14
, pp. 337
-
-
Everett, L.J.1
-
15
-
-
20144379523
-
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues
-
Zhang, X. et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc. Natl Acad. Sci. USA 102, 4459-4464 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 4459-4464
-
-
Zhang, X.1
-
16
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
Singh,R. et al.Autophagy regulates lipid metabolism.Nature458,1131-1135(2009).
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
-
17
-
-
75749122303
-
Methods in mammalian autophagy research
-
Mizushima, N., Yoshimori, T. & Levine, B. Methods in mammalian autophagy research. Cell 140, 313-326 (2010).
-
(2010)
Cell
, vol.140
, pp. 313-326
-
-
Mizushima, N.1
Yoshimori, T.2
Levine, B.3
-
18
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki, T. et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2, 217-225 (2005).
-
(2005)
Cell Metab.
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
-
19
-
-
84871364913
-
Mechanism of CREB recognition and coactivation by the CREBregulated transcriptional coactivator CRTC2
-
Luo, Q. et al. Mechanism of CREB recognition and coactivation by the CREBregulated transcriptional coactivator CRTC2. Proc. Natl Acad. Sci. USA 109, 20865-20870 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 20865-20870
-
-
Luo, Q.1
-
20
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
Settembre, C. et al. TFEB links autophagy to lysosomal biogenesis. Science 332, 1429-1433 (2011).
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
-
21
-
-
84878606239
-
TFEB controls cellular lipid metabolism through a starvationinduced autoregulatory loop
-
Settembre, C. et al. TFEB controls cellular lipid metabolism through a starvationinduced autoregulatory loop. Nature Cell Biol. 15, 647-658 (2013).
-
(2013)
Nature Cell Biol.
, vol.15
, pp. 647-658
-
-
Settembre, C.1
-
22
-
-
77956400005
-
Defective hepatic autophagy in obesity promotesERstress and causes insulin resistance
-
Yang, L., Li, P., Fu, S., Calay, E. S.&Hotamisligil, G. S. Defective hepatic autophagy in obesity promotesERstress and causes insulin resistance.CellMetab.11, 467-478 (2010).
-
(2010)
CellMetab
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
23
-
-
84923031534
-
Nutrient-sensing nuclear receptors coordinate autophagy
-
Lee, J. M. et al. Nutrient-sensing nuclear receptors coordinate autophagy. Nature http://dx.doi.org/10.1038/nature13961 (this issue).
-
Nature
-
-
Lee, J.M.1
-
24
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B. & Kroemer, G. Autophagy in the pathogenesis of disease. Cell 132, 27-42 (2008).
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
25
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated inmetabolic disease states
-
Kemper, J. K. et al. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated inmetabolic disease states. Cell Metab. 10, 392-404 (2009).
-
(2009)
Cell Metab.
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
-
26
-
-
84881457500
-
Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Czeta is critical for epigenomic regulation of liver metabolic genes
-
Seok, S. et al. Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Czeta is critical for epigenomic regulation of liver metabolic genes. J. Biol. Chem. 288, 23252-23263 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 23252-23263
-
-
Seok, S.1
-
27
-
-
84867068010
-
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor b-Klotho
-
Fu, T. et al. Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor b-Klotho. Proc. Natl Acad. Sci. USA 109, 16137-16142 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 16137-16142
-
-
Fu, T.1
|