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Volumn 5, Issue 2, 2015, Pages 129-134

Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids

Author keywords

Bile acids; Energy homeostasis; Intestine; Lipid metabolism; Liver; Transporters

Indexed keywords

BILE ACID; BILE SALT EXPORT PUMP; CELL NUCLEUS RECEPTOR; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOCHROME P450; FARNESOID X RECEPTOR; FATTY ACID; G PROTEIN COUPLED RECEPTOR; GLUCOSE; LIPID; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B1; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1B3; TRANSCRIPTION FACTOR FKHR;

EID: 84947201682     PISSN: 22113835     EISSN: 22113843     Source Type: Journal    
DOI: 10.1016/j.apsb.2015.01.001     Document Type: Review
Times cited : (95)

References (70)
  • 1
    • 84905053368 scopus 로고    scopus 로고
    • Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades
    • Hofmann AF, Hagey LR. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res 2014, 55:1553-1595.
    • (2014) J Lipid Res , vol.55 , pp. 1553-1595
    • Hofmann, A.F.1    Hagey, L.R.2
  • 3
    • 84904742368 scopus 로고    scopus 로고
    • Beyond intestinal soap-bile acids in metabolic control
    • Kuipers F, Bloks VW, Groen AK. Beyond intestinal soap-bile acids in metabolic control. Nat Rev Endocrinol 2014, 10:488-498.
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 488-498
    • Kuipers, F.1    Bloks, V.W.2    Groen, A.K.3
  • 4
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 2003, 72:137-174.
    • (2003) Annu Rev Biochem , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 5
  • 6
    • 0028866988 scopus 로고
    • Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity
    • Wong MH, Oelkers P, Dawson PA. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity. J Biol Chem 1995, 270:27228-27234.
    • (1995) J Biol Chem , vol.270 , pp. 27228-27234
    • Wong, M.H.1    Oelkers, P.2    Dawson, P.A.3
  • 7
    • 41649089141 scopus 로고    scopus 로고
    • The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis
    • Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA. The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci USA 2008, 105:3891-3896.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3891-3896
    • Rao, A.1    Haywood, J.2    Craddock, A.L.3    Belinsky, M.G.4    Kruh, G.D.5    Dawson, P.A.6
  • 8
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005, 2:217-225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5    McDonald, J.G.6
  • 9
    • 84870568785 scopus 로고    scopus 로고
    • Circulating fibroblast growth factors as metabolic regulators-a critical appraisal
    • Angelin B, Larsson TE, Rudling M. Circulating fibroblast growth factors as metabolic regulators-a critical appraisal. Cell Metab 2012, 16:693-705.
    • (2012) Cell Metab , vol.16 , pp. 693-705
    • Angelin, B.1    Larsson, T.E.2    Rudling, M.3
  • 10
    • 39449124119 scopus 로고    scopus 로고
    • Bile acids and the membrane bile acid receptor TGR5-connecting nutrition and metabolism
    • Thomas C, Auwerx J, Schoonjans K. Bile acids and the membrane bile acid receptor TGR5-connecting nutrition and metabolism. Thyroid 2008, 18:167-174.
    • (2008) Thyroid , vol.18 , pp. 167-174
    • Thomas, C.1    Auwerx, J.2    Schoonjans, K.3
  • 11
    • 84857185764 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
    • Potthoff MJ, Kliewer SA, Mangelsdorf DJ. Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. Genes Dev 2012, 26:312-324.
    • (2012) Genes Dev , vol.26 , pp. 312-324
    • Potthoff, M.J.1    Kliewer, S.A.2    Mangelsdorf, D.J.3
  • 18
    • 0942279602 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
    • Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA. Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev 2004, 18:157-169.
    • (2004) Genes Dev , vol.18 , pp. 157-169
    • Zhang, Y.1    Castellani, L.W.2    Sinal, C.J.3    Gonzalez, F.J.4    Edwards, P.A.5
  • 19
    • 0037315190 scopus 로고    scopus 로고
    • Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor
    • Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor. Mol Endocrinol 2003, 17:259-272.
    • (2003) Mol Endocrinol , vol.17 , pp. 259-272
    • Pineda Torra, I.1    Claudel, T.2    Duval, C.3    Kosykh, V.4    Fruchart, J.C.5    Staels, B.6
  • 20
    • 84864861866 scopus 로고    scopus 로고
    • Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
    • Porez G, Prawitt J, Gross B, Staels B. Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. J Lipid Res 2012, 53:1723-1737.
    • (2012) J Lipid Res , vol.53 , pp. 1723-1737
    • Porez, G.1    Prawitt, J.2    Gross, B.3    Staels, B.4
  • 21
    • 33644866636 scopus 로고    scopus 로고
    • Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4
    • Gutierrez A, Ratliff EP, Andres AM, Huang X, McKeehan WL, Davis RA. Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4. Arterioscler Thromb Vasc Biol 2006, 26:301-306.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 301-306
    • Gutierrez, A.1    Ratliff, E.P.2    Andres, A.M.3    Huang, X.4    McKeehan, W.L.5    Davis, R.A.6
  • 23
    • 0036218724 scopus 로고    scopus 로고
    • Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
    • Claudel T, Sturm E, Duez H, Torra IP, Sirvent A, Kosykh V, et al. Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. J Clin Invest 2002, 109:961-971.
    • (2002) J Clin Invest , vol.109 , pp. 961-971
    • Claudel, T.1    Sturm, E.2    Duez, H.3    Torra, I.P.4    Sirvent, A.5    Kosykh, V.6
  • 24
    • 0034791544 scopus 로고    scopus 로고
    • Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids
    • Kast HR, Nguyen CM, Sinal CJ, Jones SA, Laffitte BA, Reue K, et al. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Mol Endocrinol 2001, 15:1720-1728.
    • (2001) Mol Endocrinol , vol.15 , pp. 1720-1728
    • Kast, H.R.1    Nguyen, C.M.2    Sinal, C.J.3    Jones, S.A.4    Laffitte, B.A.5    Reue, K.6
  • 25
    • 2442463396 scopus 로고    scopus 로고
    • The farnesoid X receptor induces very low density lipoprotein receptor gene expression
    • Sirvent A, Claudel T, Martin G, Brozek J, Kosykh V, Darteil R, et al. The farnesoid X receptor induces very low density lipoprotein receptor gene expression. FEBS Lett 2004, 566:173-177.
    • (2004) FEBS Lett , vol.566 , pp. 173-177
    • Sirvent, A.1    Claudel, T.2    Martin, G.3    Brozek, J.4    Kosykh, V.5    Darteil, R.6
  • 26
    • 33645509321 scopus 로고    scopus 로고
    • Farnesoid X receptor is essential for normal glucose homeostasis
    • Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006, 116:1102-1109.
    • (2006) J Clin Invest , vol.116 , pp. 1102-1109
    • Ma, K.1    Saha, P.K.2    Chan, L.3    Moore, D.D.4
  • 27
    • 79960838523 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity
    • Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, et al. Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity. Diabetes 2011, 60:1861-1871.
    • (2011) Diabetes , vol.60 , pp. 1861-1871
    • Prawitt, J.1    Abdelkarim, M.2    Stroeve, J.H.3    Popescu, I.4    Duez, H.5    Velagapudi, V.R.6
  • 28
    • 2542435874 scopus 로고    scopus 로고
    • Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
    • Yamagata K, Daitoku H, Shimamoto Y, Matsuzaki H, Hirota K, Ishida J, et al. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J Biol Chem 2004, 279:23158-23165.
    • (2004) J Biol Chem , vol.279 , pp. 23158-23165
    • Yamagata, K.1    Daitoku, H.2    Shimamoto, Y.3    Matsuzaki, H.4    Hirota, K.5    Ishida, J.6
  • 29
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 2001, 413:131-138.
    • (2001) Nature , vol.413 , pp. 131-138
    • Yoon, J.C.1    Puigserver, P.2    Chen, G.3    Donovan, J.4    Wu, Z.5    Rhee, J.6
  • 32
    • 18344394556 scopus 로고    scopus 로고
    • Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity
    • Tomlinson E, Fu L, John L, Hultgren B, Huang X, Renz M, et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 2002, 143:1741-1747.
    • (2002) Endocrinology , vol.143 , pp. 1741-1747
    • Tomlinson, E.1    Fu, L.2    John, L.3    Hultgren, B.4    Huang, X.5    Renz, M.6
  • 33
    • 65649152582 scopus 로고    scopus 로고
    • Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis
    • Bhatnagar S, Damron HA, Hillgartner FB. Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J Biol Chem 2009, 284:10023-10033.
    • (2009) J Biol Chem , vol.284 , pp. 10023-10033
    • Bhatnagar, S.1    Damron, H.A.2    Hillgartner, F.B.3
  • 36
    • 84871694003 scopus 로고    scopus 로고
    • Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats
    • Ryan KK, Kohli R, Gutierrez-Aguilar R, Gaitonde SG, Woods SC, Seeley RJ. Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats. Endocrinology 2013, 154:9-15.
    • (2013) Endocrinology , vol.154 , pp. 9-15
    • Ryan, K.K.1    Kohli, R.2    Gutierrez-Aguilar, R.3    Gaitonde, S.G.4    Woods, S.C.5    Seeley, R.J.6
  • 37
    • 79953129095 scopus 로고    scopus 로고
    • FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis
    • Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, et al. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 2011, 331:1621-1624.
    • (2011) Science , vol.331 , pp. 1621-1624
    • Kir, S.1    Beddow, S.A.2    Samuel, V.T.3    Miller, P.4    Previs, S.F.5    Suino-Powell, K.6
  • 38
    • 79958066536 scopus 로고    scopus 로고
    • FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway
    • Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, et al. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. Cell Metab 2011, 13:729-738.
    • (2011) Cell Metab , vol.13 , pp. 729-738
    • Potthoff, M.J.1    Boney-Montoya, J.2    Choi, M.3    He, T.4    Sunny, N.E.5    Satapati, S.6
  • 39
    • 66449085572 scopus 로고    scopus 로고
    • FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action
    • Shin DJ, Osborne TF. FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem 2009, 284:11110-11120.
    • (2009) J Biol Chem , vol.284 , pp. 11110-11120
    • Shin, D.J.1    Osborne, T.F.2
  • 40
    • 84880832459 scopus 로고    scopus 로고
    • Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice
    • Yu XX, Watts LM, Manchem VP, Chakravarty K, Monia BP, McCaleb ML, et al. Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice. PLoS One 2013, 8:e66923.
    • (2013) PLoS One , vol.8 , pp. e66923
    • Yu, X.X.1    Watts, L.M.2    Manchem, V.P.3    Chakravarty, K.4    Monia, B.P.5    McCaleb, M.L.6
  • 41
    • 34948821192 scopus 로고    scopus 로고
    • FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver
    • Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL. FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 2007, 56:2501-2510.
    • (2007) Diabetes , vol.56 , pp. 2501-2510
    • Huang, X.1    Yang, C.2    Luo, Y.3    Jin, C.4    Wang, F.5    McKeehan, W.L.6
  • 43
    • 84905257719 scopus 로고    scopus 로고
    • Bile acid signaling in metabolic disease and drug therapy
    • Li T, Chiang JY. Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 2014, 66:948-983.
    • (2014) Pharmacol Rev , vol.66 , pp. 948-983
    • Li, T.1    Chiang, J.Y.2
  • 44
    • 84871304988 scopus 로고    scopus 로고
    • The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
    • Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, et al. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 2013, 144:145-154.
    • (2013) Gastroenterology , vol.144 , pp. 145-154
    • Alemi, F.1    Poole, D.P.2    Chiu, J.3    Schoonjans, K.4    Cattaruzza, F.5    Grider, J.R.6
  • 46
  • 47
    • 77952562273 scopus 로고    scopus 로고
    • Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice
    • Vassileva G, Hu W, Hoos L, Tetzloff G, Yang S, Liu L, et al. Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice. J Endocrinol 2010, 205:225-232.
    • (2010) J Endocrinol , vol.205 , pp. 225-232
    • Vassileva, G.1    Hu, W.2    Hoos, L.3    Tetzloff, G.4    Yang, S.5    Liu, L.6
  • 49
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 2006, 439:484-489.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3    Christoffolete, M.A.4    Kim, B.W.5    Sato, H.6
  • 50
    • 84865603263 scopus 로고    scopus 로고
    • Bile acid binding resin improves metabolic control through the induction of energy expenditure
    • Watanabe M, Morimoto K, Houten SM, Kaneko-Iwasaki N, Sugizaki T, Horai Y, et al. Bile acid binding resin improves metabolic control through the induction of energy expenditure. PLoS One 2012, 7:e38286.
    • (2012) PLoS One , vol.7 , pp. e38286
    • Watanabe, M.1    Morimoto, K.2    Houten, S.M.3    Kaneko-Iwasaki, N.4    Sugizaki, T.5    Horai, Y.6
  • 51
    • 84861682490 scopus 로고    scopus 로고
    • TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
    • Harach T, Pols TW, Nomura M, Maida A, Watanabe M, Auwerx J, et al. TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci Rep 2012, 2:430.
    • (2012) Sci Rep , vol.2 , pp. 430
    • Harach, T.1    Pols, T.W.2    Nomura, M.3    Maida, A.4    Watanabe, M.5    Auwerx, J.6
  • 53
    • 84855317103 scopus 로고    scopus 로고
    • Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet
    • Mells JE, Fu PP, Sharma S, Olson D, Cheng L, Handy JA, et al. Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol 2012, 302:G225-G235.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G225-G235
    • Mells, J.E.1    Fu, P.P.2    Sharma, S.3    Olson, D.4    Cheng, L.5    Handy, J.A.6
  • 55
    • 84855850294 scopus 로고    scopus 로고
    • Bile acid sequestrants: more than simple resins
    • Out C, Groen AK, Brufau G. Bile acid sequestrants: more than simple resins. Curr Opin Lipidol 2012, 23:43-55.
    • (2012) Curr Opin Lipidol , vol.23 , pp. 43-55
    • Out, C.1    Groen, A.K.2    Brufau, G.3
  • 56
  • 57
    • 0019222584 scopus 로고
    • Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia
    • Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia. Drugs 1980, 19:161-180.
    • (1980) Drugs , vol.19 , pp. 161-180
    • Heel, R.C.1    Brogden, R.N.2    Pakes, G.E.3    Speight, T.M.4    Avery, G.S.5
  • 58
    • 0021350001 scopus 로고
    • The lipid research clinics coronary primary prevention trial results. I. Reduction in incidence of coronary heart disease
    • The lipid research clinics coronary primary prevention trial results. I. Reduction in incidence of coronary heart disease. JAMA 1984, 251:351-364.
    • (1984) JAMA , vol.251 , pp. 351-364
  • 59
    • 33947120281 scopus 로고    scopus 로고
    • Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes
    • Zieve FJ, Kalin MF, Schwartz SL, Jones MR, Bailey WL. Results of the glucose-lowering effect of WelChol study (GLOWS): a randomized, double-blind, placebo-controlled pilot study evaluating the effect of colesevelam hydrochloride on glycemic control in subjects with type 2 diabetes. Clin Ther 2007, 29:74-83.
    • (2007) Clin Ther , vol.29 , pp. 74-83
    • Zieve, F.J.1    Kalin, M.F.2    Schwartz, S.L.3    Jones, M.R.4    Bailey, W.L.5
  • 60
    • 33847057732 scopus 로고    scopus 로고
    • Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin
    • Kobayashi M, Ikegami H, Fujisawa T, Nojima K, Kawabata Y, Noso S, et al. Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes 2007, 56:239-247.
    • (2007) Diabetes , vol.56 , pp. 239-247
    • Kobayashi, M.1    Ikegami, H.2    Fujisawa, T.3    Nojima, K.4    Kawabata, Y.5    Noso, S.6
  • 61
    • 77953766726 scopus 로고    scopus 로고
    • Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats
    • Chen L, McNulty J, Anderson D, Liu Y, Nystrom C, Bullard S, et al. Cholestyramine reverses hyperglycemia and enhances glucose-stimulated glucagon-like peptide 1 release in Zucker diabetic fatty rats. J Pharmacol Exp Ther 2010, 334:164-170.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 164-170
    • Chen, L.1    McNulty, J.2    Anderson, D.3    Liu, Y.4    Nystrom, C.5    Bullard, S.6
  • 62
    • 84876802991 scopus 로고    scopus 로고
    • Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion
    • Sugimoto-Kawabata K, Shimada H, Sakai K, Suzuki K, Kelder T, Pieterman EJ, et al. Colestilan decreases weight gain by enhanced NEFA incorporation in biliary lipids and fecal lipid excretion. J Lipid Res 2013, 54:1255-1264.
    • (2013) J Lipid Res , vol.54 , pp. 1255-1264
    • Sugimoto-Kawabata, K.1    Shimada, H.2    Sakai, K.3    Suzuki, K.4    Kelder, T.5    Pieterman, E.J.6
  • 63
    • 0036692428 scopus 로고    scopus 로고
    • Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94
    • Root C, Smith CD, Sundseth SS, Pink HM, Wilson JG, Lewis MC. Ileal bile acid transporter inhibition, CYP7A1 induction, and antilipemic action of 264W94. J Lipid Res 2002, 43:1320-1330.
    • (2002) J Lipid Res , vol.43 , pp. 1320-1330
    • Root, C.1    Smith, C.D.2    Sundseth, S.S.3    Pink, H.M.4    Wilson, J.G.5    Lewis, M.C.6
  • 64
    • 0344309204 scopus 로고    scopus 로고
    • SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs
    • West KL, Zern TL, Butteiger DN, Keller BT, Fernandez ML. SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs. Atherosclerosis 2003, 171:201-210.
    • (2003) Atherosclerosis , vol.171 , pp. 201-210
    • West, K.L.1    Zern, T.L.2    Butteiger, D.N.3    Keller, B.T.4    Fernandez, M.L.5
  • 66
    • 84861477433 scopus 로고    scopus 로고
    • Inhibition of intestinal bile acid transporter SLC10A2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice
    • Lundåsen T, Andersson EM, Snaith M, Lindmark H, Lundberg J, Östlund-Lindqvist AM, et al. Inhibition of intestinal bile acid transporter SLC10A2 improves triglyceride metabolism and normalizes elevated plasma glucose levels in mice. PLoS One 2012, 7:e37787.
    • (2012) PLoS One , vol.7 , pp. e37787
    • Lundåsen, T.1    Andersson, E.M.2    Snaith, M.3    Lindmark, H.4    Lundberg, J.5    Östlund-Lindqvist, A.M.6
  • 67
    • 83455243025 scopus 로고    scopus 로고
    • Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes
    • Chen L, Yao X, Young A, McNulty J, Anderson D, Liu Y, et al. Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. Am J Physiol Endocrinol Metab 2012, 302:E68-E76.
    • (2012) Am J Physiol Endocrinol Metab , vol.302 , pp. E68-E76
    • Chen, L.1    Yao, X.2    Young, A.3    McNulty, J.4    Anderson, D.5    Liu, Y.6
  • 68
    • 84863986239 scopus 로고    scopus 로고
    • Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism
    • Lan T, Rao A, Haywood J, Kock ND, Dawson PA. Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism. J Hepatol 2012, 57:359-365.
    • (2012) J Hepatol , vol.57 , pp. 359-365
    • Lan, T.1    Rao, A.2    Haywood, J.3    Kock, N.D.4    Dawson, P.A.5
  • 70
    • 51149089559 scopus 로고    scopus 로고
    • Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver
    • Ballatori N, Fang F, Christian WV, Li N, Hammond CL. Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol 2008, 295:G179-G186.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , pp. G179-G186
    • Ballatori, N.1    Fang, F.2    Christian, W.V.3    Li, N.4    Hammond, C.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.