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Volumn 16, Issue 9, 2017, Pages 885-896

Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases

Author keywords

Autoimmune cholestatic liver diseases; Bile acids; Intestinal microbiota

Indexed keywords

BICARBONATE; BILE ACID; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR; OBETICHOLIC ACID; TRANSMEMBRANE G PROTEIN COUPLED RECEPTOR 5; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

EID: 85025127280     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2017.07.002     Document Type: Review
Times cited : (184)

References (196)
  • 1
    • 0019204917 scopus 로고
    • Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology
    • Chapman, R.W., Arborgh, B., Rhodes, J., Summerfield, J., Dick, R., Scheuer, P., et al. Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology. Gut 21 (1980), 870–877.
    • (1980) Gut , vol.21 , pp. 870-877
    • Chapman, R.W.1    Arborgh, B.2    Rhodes, J.3    Summerfield, J.4    Dick, R.5    Scheuer, P.6
  • 3
    • 39549115685 scopus 로고    scopus 로고
    • The causes of primary biliary cirrhosis: Convenient and inconvenient truths
    • Gershwin, M.E., Mackay, I.R., The causes of primary biliary cirrhosis: Convenient and inconvenient truths. Hepatology 47 (2008), 737–745.
    • (2008) Hepatology , vol.47 , pp. 737-745
    • Gershwin, M.E.1    Mackay, I.R.2
  • 5
    • 85027943670 scopus 로고    scopus 로고
    • The evolution of natural history of primary sclerosing cholangitis
    • Takakura, W.R., Tabibian, J.H., Bowlus, C.L., The evolution of natural history of primary sclerosing cholangitis. Curr Opin Gastroenterol 33 (2017), 71–77.
    • (2017) Curr Opin Gastroenterol , vol.33 , pp. 71-77
    • Takakura, W.R.1    Tabibian, J.H.2    Bowlus, C.L.3
  • 6
    • 85006054017 scopus 로고    scopus 로고
    • Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis
    • Chung, B.K., Guevel, B.T., Reynolds, G.M., Gupta Udatha, D.B., Henriksen, E.K., Stamataki, Z., et al. Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis. J Autoimmun 77 (2017), 45–54.
    • (2017) J Autoimmun , vol.77 , pp. 45-54
    • Chung, B.K.1    Guevel, B.T.2    Reynolds, G.M.3    Gupta Udatha, D.B.4    Henriksen, E.K.5    Stamataki, Z.6
  • 7
    • 85006515428 scopus 로고    scopus 로고
    • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
    • Ji, S.G., Juran, B.D., Mucha, S., Folseraas, T., Jostins, L., Melum, E., et al. Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. Nat Genet 49 (2017), 269–273.
    • (2017) Nat Genet , vol.49 , pp. 269-273
    • Ji, S.G.1    Juran, B.D.2    Mucha, S.3    Folseraas, T.4    Jostins, L.5    Melum, E.6
  • 8
    • 84947763568 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis: multiple phenotypes, multiple approaches
    • Sarkar, S., Bowlus, C.L., Primary sclerosing cholangitis: multiple phenotypes, multiple approaches. Clin Liver Dis 20 (2016), 67–77.
    • (2016) Clin Liver Dis , vol.20 , pp. 67-77
    • Sarkar, S.1    Bowlus, C.L.2
  • 9
    • 85013895102 scopus 로고    scopus 로고
    • Checkpoint-based immunotherapy for autoimmune diseases - opportunities and challenges
    • He, X.S., Gershwin, M.E., Ansari, A.A., Checkpoint-based immunotherapy for autoimmune diseases - opportunities and challenges. J Autoimmun 79 (2017), 1–3.
    • (2017) J Autoimmun , vol.79 , pp. 1-3
    • He, X.S.1    Gershwin, M.E.2    Ansari, A.A.3
  • 11
    • 84953209650 scopus 로고    scopus 로고
    • Using GWAS to identify genetic predisposition in hepatic autoimmunity
    • Webb, G.J., Hirschfield, G.M., Using GWAS to identify genetic predisposition in hepatic autoimmunity. J Autoimmun 66 (2016), 25–39.
    • (2016) J Autoimmun , vol.66 , pp. 25-39
    • Webb, G.J.1    Hirschfield, G.M.2
  • 12
    • 84946472960 scopus 로고    scopus 로고
    • The immunogenetics of primary biliary cirrhosis: a comprehensive review
    • Webb, G.J., Siminovitch, K.A., Hirschfield, G.M., The immunogenetics of primary biliary cirrhosis: a comprehensive review. J Autoimmun 64 (2015), 42–52.
    • (2015) J Autoimmun , vol.64 , pp. 42-52
    • Webb, G.J.1    Siminovitch, K.A.2    Hirschfield, G.M.3
  • 14
    • 84939893722 scopus 로고    scopus 로고
    • Genetics in PBC: what do the “risk genes” teach us?
    • Hirschfield, G.M., Siminovitch, K.A., Genetics in PBC: what do the “risk genes” teach us?. Clin Rev Allergy Immunol 48 (2015), 176–181.
    • (2015) Clin Rev Allergy Immunol , vol.48 , pp. 176-181
    • Hirschfield, G.M.1    Siminovitch, K.A.2
  • 15
    • 84957431606 scopus 로고    scopus 로고
    • The natural history and prognosis of primary biliary cirrhosis with clinical features of autoimmune hepatitis
    • Yang, F., Wang, Q., Wang, Z., Miao, Q., Xiao, X., Tang, R., et al. The natural history and prognosis of primary biliary cirrhosis with clinical features of autoimmune hepatitis. Clin Rev Allergy Immunol 50 (2016), 114–123.
    • (2016) Clin Rev Allergy Immunol , vol.50 , pp. 114-123
    • Yang, F.1    Wang, Q.2    Wang, Z.3    Miao, Q.4    Xiao, X.5    Tang, R.6
  • 16
    • 85016485058 scopus 로고    scopus 로고
    • Finding the cure for primary biliary cholangitis - still waiting
    • Tanaka, A., Gershwin, M.E., Finding the cure for primary biliary cholangitis - still waiting. Liver Int 37 (2017), 500–502.
    • (2017) Liver Int , vol.37 , pp. 500-502
    • Tanaka, A.1    Gershwin, M.E.2
  • 17
    • 84958161655 scopus 로고    scopus 로고
    • Primary biliary cirrhosis beyond ursodeoxycholic acid
    • Corpechot, C., Primary biliary cirrhosis beyond ursodeoxycholic acid. Semin Liver Dis 36 (2016), 15–26.
    • (2016) Semin Liver Dis , vol.36 , pp. 15-26
    • Corpechot, C.1
  • 18
    • 84958182341 scopus 로고    scopus 로고
    • New therapeutic strategies for primary sclerosing cholangitis
    • Williamson, K.D., Chapman, R.W., New therapeutic strategies for primary sclerosing cholangitis. Semin Liver Dis 36 (2016), 5–14.
    • (2016) Semin Liver Dis , vol.36 , pp. 5-14
    • Williamson, K.D.1    Chapman, R.W.2
  • 19
    • 84953449930 scopus 로고    scopus 로고
    • A review of the medical treatment of primary sclerosing cholangitis in the 21st century[J]
    • Goode, E.C., Rushbrook, S.M., A review of the medical treatment of primary sclerosing cholangitis in the 21st century[J]. Therapeutic advances in chronic disease 7:1 (2016), 68–85.
    • (2016) Therapeutic advances in chronic disease , vol.7 , Issue.1 , pp. 68-85
    • Goode, E.C.1    Rushbrook, S.M.2
  • 20
    • 0031739413 scopus 로고    scopus 로고
    • Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis?
    • Pereira, S., Rhodes, J., Campbell, B., Kumar, D., Bain, I., Murphy, G., et al. Biliary lactoferrin concentrations are increased in active inflammatory bowel disease: a factor in the pathogenesis of primary sclerosing cholangitis?. Clin Sci 95 (1998), 637–644.
    • (1998) Clin Sci , vol.95 , pp. 637-644
    • Pereira, S.1    Rhodes, J.2    Campbell, B.3    Kumar, D.4    Bain, I.5    Murphy, G.6
  • 21
    • 84947864210 scopus 로고    scopus 로고
    • The gut-liver axis in primary sclerosing cholangitis
    • Eksteen, B., The gut-liver axis in primary sclerosing cholangitis. Clin Liver Dis 20 (2016), 1–14.
    • (2016) Clin Liver Dis , vol.20 , pp. 1-14
    • Eksteen, B.1
  • 23
    • 20444493331 scopus 로고    scopus 로고
    • The interaction between bacteria and bile
    • Begley, M., Gahan, C.G., Hill, C., The interaction between bacteria and bile. FEMS Microbiol Rev 29 (2005), 625–651.
    • (2005) FEMS Microbiol Rev , vol.29 , pp. 625-651
    • Begley, M.1    Gahan, C.G.2    Hill, C.3
  • 24
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: regulation of synthesis
    • Chiang, J.Y., Bile acids: regulation of synthesis. J Lipid Res 50 (2009), 1955–1966.
    • (2009) J Lipid Res , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 25
    • 0025247125 scopus 로고
    • Hepatic injury induced by bile salts: correlation between biochemical and morphological events
    • Schmucker, D.L., Ohta, M., Kanai, S., Sato, Y., Kitani, K., Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology 12 (1990), 1216–1221.
    • (1990) Hepatology , vol.12 , pp. 1216-1221
    • Schmucker, D.L.1    Ohta, M.2    Kanai, S.3    Sato, Y.4    Kitani, K.5
  • 26
    • 84951209574 scopus 로고    scopus 로고
    • Implications of microbiota and bile acid in liver injury and regeneration
    • Liu, H.X., Keane, R., Sheng, L., Wan, Y.J., Implications of microbiota and bile acid in liver injury and regeneration. J Hepatol 63 (2015), 1502–1510.
    • (2015) J Hepatol , vol.63 , pp. 1502-1510
    • Liu, H.X.1    Keane, R.2    Sheng, L.3    Wan, Y.J.4
  • 28
    • 0035657634 scopus 로고    scopus 로고
    • Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids
    • Chen, W., Owsley, E., Yang, Y., Stroup, D., Chiang, J.Y., Nuclear receptor-mediated repression of human cholesterol 7α-hydroxylase gene transcription by bile acids. J Lipid Res 42 (2001), 1402–1412.
    • (2001) J Lipid Res , vol.42 , pp. 1402-1412
    • Chen, W.1    Owsley, E.2    Yang, Y.3    Stroup, D.4    Chiang, J.Y.5
  • 29
    • 78650793157 scopus 로고    scopus 로고
    • Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis
    • Allen, K., Jaeschke, H., Copple, B.L., Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 178 (2011), 175–186.
    • (2011) Am J Pathol , vol.178 , pp. 175-186
    • Allen, K.1    Jaeschke, H.2    Copple, B.L.3
  • 30
    • 2442662132 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
    • Schoemaker, M.H., Conde de la Rosa, L., Buist-Homan, M., Vrenken, T.E., Havinga, R., Poelstra, K., et al. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology 39 (2004), 1563–1573.
    • (2004) Hepatology , vol.39 , pp. 1563-1573
    • Schoemaker, M.H.1    Conde de la Rosa, L.2    Buist-Homan, M.3    Vrenken, T.E.4    Havinga, R.5    Poelstra, K.6
  • 31
    • 65649124573 scopus 로고    scopus 로고
    • Bile-acid-induced cell injury and protection
    • Perez, M.J., Briz, O., Bile-acid-induced cell injury and protection. World J Gastroenterol 15 (2009), 1677–1689.
    • (2009) World J Gastroenterol , vol.15 , pp. 1677-1689
    • Perez, M.J.1    Briz, O.2
  • 32
    • 0032504568 scopus 로고    scopus 로고
    • The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy
    • Lemasters, J.J., Nieminen, A.-L., Qian, T., Trost, L.C., Elmore, S.P., Nishimura, Y., et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta Bioenerg 1366 (1998), 177–196.
    • (1998) Biochim Biophys Acta Bioenerg , vol.1366 , pp. 177-196
    • Lemasters, J.J.1    Nieminen, A.-L.2    Qian, T.3    Trost, L.C.4    Elmore, S.P.5    Nishimura, Y.6
  • 33
    • 0141717661 scopus 로고    scopus 로고
    • Death receptor activation-induced hepatocyte apoptosis and liver injury
    • Yin, X.-M., Ding, W.-X., Death receptor activation-induced hepatocyte apoptosis and liver injury. Curr Mol Med 3 (2003), 491–508.
    • (2003) Curr Mol Med , vol.3 , pp. 491-508
    • Yin, X.-M.1    Ding, W.-X.2
  • 34
    • 79952708723 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in liver disease
    • Malhi, H., Kaufman, R.J., Endoplasmic reticulum stress in liver disease. J Hepatol 54 (2011), 795–809.
    • (2011) J Hepatol , vol.54 , pp. 795-809
    • Malhi, H.1    Kaufman, R.J.2
  • 36
    • 12344332518 scopus 로고    scopus 로고
    • Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes
    • Borgognone, M., Pérez, L.M., Basiglio, C.L., Ochoa, J.E., Roma, M.G., Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes. Toxicol Sci 83 (2005), 114–125.
    • (2005) Toxicol Sci , vol.83 , pp. 114-125
    • Borgognone, M.1    Pérez, L.M.2    Basiglio, C.L.3    Ochoa, J.E.4    Roma, M.G.5
  • 37
    • 0036775488 scopus 로고    scopus 로고
    • Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy
    • Lemasters, J.J., Qian, T., He, L., Kim, J.-S., Elmore, S.P., Cascio, W.E., et al. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal 4 (2002), 769–781.
    • (2002) Antioxid Redox Signal , vol.4 , pp. 769-781
    • Lemasters, J.J.1    Qian, T.2    He, L.3    Kim, J.-S.4    Elmore, S.P.5    Cascio, W.E.6
  • 38
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
    • Spivey, J.R., Bronk, S.F., Gores, G.J., Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J Clin Investig, 92, 1993, 17.
    • (1993) J Clin Investig , vol.92 , pp. 17
    • Spivey, J.R.1    Bronk, S.F.2    Gores, G.J.3
  • 39
    • 77957940106 scopus 로고    scopus 로고
    • The biliary HCO3 − umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies
    • Beuers, U., Hohenester, S., de Buy Wenniger, L.J.M., Kremer, A.E., Jansen, P.L., Elferink, R.P., The biliary HCO3 − umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology 52 (2010), 1489–1496.
    • (2010) Hepatology , vol.52 , pp. 1489-1496
    • Beuers, U.1    Hohenester, S.2    de Buy Wenniger, L.J.M.3    Kremer, A.E.4    Jansen, P.L.5    Elferink, R.P.6
  • 41
    • 79959523283 scopus 로고    scopus 로고
    • Role of the anion exchanger 2 in the pathogenesis and treatment of primary biliary cirrhosis
    • Medina, J.F., Role of the anion exchanger 2 in the pathogenesis and treatment of primary biliary cirrhosis. Dig Dis 29 (2011), 103–112.
    • (2011) Dig Dis , vol.29 , pp. 103-112
    • Medina, J.F.1
  • 42
    • 84995579603 scopus 로고    scopus 로고
    • Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis
    • Hisamoto, S., Shimoda, S., Harada, K., Iwasaka, S., Onohara, S., Chong, Y., et al. Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis. J Autoimmun 75 (2016), 150–160.
    • (2016) J Autoimmun , vol.75 , pp. 150-160
    • Hisamoto, S.1    Shimoda, S.2    Harada, K.3    Iwasaka, S.4    Onohara, S.5    Chong, Y.6
  • 43
    • 85022085353 scopus 로고    scopus 로고
    • Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response
    • Cai, S.-Y., Ouyang, X., Chen, Y., Soroka, C.J., Wang, J., Mennone, A., et al. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight, 2, 2017.
    • (2017) JCI Insight , vol.2
    • Cai, S.-Y.1    Ouyang, X.2    Chen, Y.3    Soroka, C.J.4    Wang, J.5    Mennone, A.6
  • 44
    • 33744945790 scopus 로고    scopus 로고
    • Biliary obstruction selectively expands and activates liver myeloid dendritic cells
    • Bleier, J.I., Katz, S.C., Chaudhry, U.I., Pillarisetty, V.G., Kingham, T.P., Shah, A.B., et al. Biliary obstruction selectively expands and activates liver myeloid dendritic cells. J Immunol 176 (2006), 7189–7195.
    • (2006) J Immunol , vol.176 , pp. 7189-7195
    • Bleier, J.I.1    Katz, S.C.2    Chaudhry, U.I.3    Pillarisetty, V.G.4    Kingham, T.P.5    Shah, A.B.6
  • 45
    • 84886689508 scopus 로고    scopus 로고
    • IL-17A synergistically enhances bile acid–induced inflammation during obstructive cholestasis
    • O'Brien, K.M., Allen, K.M., Rockwell, C.E., Towery, K., Luyendyk, J.P., Copple, B.L., IL-17A synergistically enhances bile acid–induced inflammation during obstructive cholestasis. Am J Pathol 183 (2013), 1498–1507.
    • (2013) Am J Pathol , vol.183 , pp. 1498-1507
    • O'Brien, K.M.1    Allen, K.M.2    Rockwell, C.E.3    Towery, K.4    Luyendyk, J.P.5    Copple, B.L.6
  • 46
    • 70849133150 scopus 로고    scopus 로고
    • Bile acid transporters
    • Dawson, P.A., Lan, T., Rao, A., Bile acid transporters. J Lipid Res 50 (2009), 2340–2357.
    • (2009) J Lipid Res , vol.50 , pp. 2340-2357
    • Dawson, P.A.1    Lan, T.2    Rao, A.3
  • 47
    • 0032558588 scopus 로고    scopus 로고
    • Molecular pathogenesis of cholestasis
    • Trauner, M., Meier, P.J., Boyer, J.L., Molecular pathogenesis of cholestasis. N Engl J Med 339 (1998), 1217–1227.
    • (1998) N Engl J Med , vol.339 , pp. 1217-1227
    • Trauner, M.1    Meier, P.J.2    Boyer, J.L.3
  • 48
    • 33745774784 scopus 로고    scopus 로고
    • Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations
    • Zollner, G., Marschall, H.-U., Wagner, M., Trauner, M., Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm 3 (2006), 231–251.
    • (2006) Mol Pharm , vol.3 , pp. 231-251
    • Zollner, G.1    Marschall, H.-U.2    Wagner, M.3    Trauner, M.4
  • 49
    • 79953173235 scopus 로고    scopus 로고
    • Nuclear receptors as new perspective for the management of liver diseases
    • e12
    • Trauner, M., Halilbasic, E., Nuclear receptors as new perspective for the management of liver diseases. Gastroenterology 140:4 (2011), 1120–1125 e12.
    • (2011) Gastroenterology , vol.140 , Issue.4 , pp. 1120-1125
    • Trauner, M.1    Halilbasic, E.2
  • 50
    • 84872741573 scopus 로고    scopus 로고
    • Nuclear receptors in bile acid metabolism
    • Li, T., Chiang, J.Y., Nuclear receptors in bile acid metabolism. Drug Metab Rev 45 (2013), 145–155.
    • (2013) Drug Metab Rev , vol.45 , pp. 145-155
    • Li, T.1    Chiang, J.Y.2
  • 51
    • 84876371590 scopus 로고    scopus 로고
    • Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia
    • Torres, J., Bao, X., Iuga, A.C., Chen, A., Harpaz, N., Ullman, T., et al. Farnesoid X receptor expression is decreased in colonic mucosa of patients with primary sclerosing cholangitis and colitis-associated neoplasia. Inflamm Bowel Dis 19 (2013), 275–282.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 275-282
    • Torres, J.1    Bao, X.2    Iuga, A.C.3    Chen, A.4    Harpaz, N.5    Ullman, T.6
  • 52
    • 84856159269 scopus 로고    scopus 로고
    • Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
    • e4
    • Modica, S., Petruzzelli, M., Bellafante, E., Murzilli, S., Salvatore, L., Celli, N., et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 142:2 (2012), 355–365 e4.
    • (2012) Gastroenterology , vol.142 , Issue.2 , pp. 355-365
    • Modica, S.1    Petruzzelli, M.2    Bellafante, E.3    Murzilli, S.4    Salvatore, L.5    Celli, N.6
  • 53
    • 84870334072 scopus 로고    scopus 로고
    • Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo
    • Kir, S., Zhang, Y., Gerard, R.D., Kliewer, S.A., Mangelsdorf, D.J., Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo. J Biol Chem 287 (2012), 41334–41341.
    • (2012) J Biol Chem , vol.287 , pp. 41334-41341
    • Kir, S.1    Zhang, Y.2    Gerard, R.D.3    Kliewer, S.A.4    Mangelsdorf, D.J.5
  • 54
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C.L., McDonald, J.G., et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2 (2005), 217–225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5    McDonald, J.G.6
  • 55
    • 84865540426 scopus 로고    scopus 로고
    • Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
    • Kong, B., Wang, L., Chiang, J.Y., Zhang, Y., Klaassen, C.D., Guo, G.L., Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 56 (2012), 1034–1043.
    • (2012) Hepatology , vol.56 , pp. 1034-1043
    • Kong, B.1    Wang, L.2    Chiang, J.Y.3    Zhang, Y.4    Klaassen, C.D.5    Guo, G.L.6
  • 56
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D.J., Suchy, F.J., Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 276 (2001), 28857–28865.
    • (2001) J Biol Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 57
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • Kast, H.R., Goodwin, B., Tarr, P.T., Jones, S.A., Anisfeld, A.M., Stoltz, C.M., et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 277 (2002), 2908–2915.
    • (2002) J Biol Chem , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6
  • 58
    • 33646871585 scopus 로고    scopus 로고
    • Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTα-OSTβ in cholestasis in humans and rodents
    • Boyer, J.L., Trauner, M., Mennone, A., Soroka, C.J., Cai, S.-Y., Moustafa, T., et al. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTα-OSTβ in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 290:6 (2006), G1124–G1130.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , Issue.6 , pp. G1124-G1130
    • Boyer, J.L.1    Trauner, M.2    Mennone, A.3    Soroka, C.J.4    Cai, S.-Y.5    Moustafa, T.6
  • 59
    • 0034950514 scopus 로고    scopus 로고
    • The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp
    • Denson, L.A., Sturm, E., Echevarria, W., Zimmerman, T.L., Makishima, M., Mangelsdorf, D.J., et al. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology 121 (2001), 140–147.
    • (2001) Gastroenterology , vol.121 , pp. 140-147
    • Denson, L.A.1    Sturm, E.2    Echevarria, W.3    Zimmerman, T.L.4    Makishima, M.5    Mangelsdorf, D.J.6
  • 61
    • 77952674868 scopus 로고    scopus 로고
    • The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    • Mencarelli, A., Renga, B., Migliorati, M., Cipriani, S., Distrutti, E., Santucci, L., et al. The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 183 (2009), 6657–6666.
    • (2009) J Immunol , vol.183 , pp. 6657-6666
    • Mencarelli, A.1    Renga, B.2    Migliorati, M.3    Cipriani, S.4    Distrutti, E.5    Santucci, L.6
  • 62
    • 84883150093 scopus 로고    scopus 로고
    • Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management
    • Eaton, J.E., Talwalkar, J.A., Lazaridis, K.N., Gores, G.J., Lindor, K.D., Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management. Gastroenterology 145 (2013), 521–536.
    • (2013) Gastroenterology , vol.145 , pp. 521-536
    • Eaton, J.E.1    Talwalkar, J.A.2    Lazaridis, K.N.3    Gores, G.J.4    Lindor, K.D.5
  • 64
    • 43949098305 scopus 로고    scopus 로고
    • Mechanisms of hepatocyte growth factor–mediated and epidermal growth factor–mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium
    • Limaye, P.B., Bowen, W.C., Orr, A.V., Luo, J., Tseng, G.C., Michalopoulos, G.K., Mechanisms of hepatocyte growth factor–mediated and epidermal growth factor–mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium. Hepatology 47 (2008), 1702–1713.
    • (2008) Hepatology , vol.47 , pp. 1702-1713
    • Limaye, P.B.1    Bowen, W.C.2    Orr, A.V.3    Luo, J.4    Tseng, G.C.5    Michalopoulos, G.K.6
  • 65
    • 84939815585 scopus 로고    scopus 로고
    • TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?
    • Keitel, V., Reich, M., Häussinger, D., TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?. Clin Rev Allergy Immunol 48 (2015), 218–225.
    • (2015) Clin Rev Allergy Immunol , vol.48 , pp. 218-225
    • Keitel, V.1    Reich, M.2    Häussinger, D.3
  • 66
    • 84979781267 scopus 로고    scopus 로고
    • G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice
    • Donepudi, A.C., Boehme, S., Li, F., Chiang, J.Y., G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. Hepatology 65.3 (2017), 813–827.
    • (2017) Hepatology , vol.65.3 , pp. 813-827
    • Donepudi, A.C.1    Boehme, S.2    Li, F.3    Chiang, J.Y.4
  • 67
    • 80053308007 scopus 로고    scopus 로고
    • The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice
    • Wang, Y.D., Chen, W.D., Yu, D., Forman, B.M., Huang, W., The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology 54 (2011), 1421–1432.
    • (2011) Hepatology , vol.54 , pp. 1421-1432
    • Wang, Y.D.1    Chen, W.D.2    Yu, D.3    Forman, B.M.4    Huang, W.5
  • 68
    • 82955168360 scopus 로고    scopus 로고
    • TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
    • Pols, T.W., Nomura, M., Harach, T., Sasso, G.L., Oosterveer, M.H., Thomas, C., et al. TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 14 (2011), 747–757.
    • (2011) Cell Metab , vol.14 , pp. 747-757
    • Pols, T.W.1    Nomura, M.2    Harach, T.3    Sasso, G.L.4    Oosterveer, M.H.5    Thomas, C.6
  • 69
    • 84868360297 scopus 로고    scopus 로고
    • Perspective: TGR5 (Gpbar-1) in liver physiology and disease
    • Keitel, V., Häussinger, D., Perspective: TGR5 (Gpbar-1) in liver physiology and disease. Clin Res Hepatol Gastroenterol 36 (2012), 412–419.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , pp. 412-419
    • Keitel, V.1    Häussinger, D.2
  • 70
    • 84947202508 scopus 로고    scopus 로고
    • Bile acid signaling and biliary functions
    • Jones, H., Alpini, G., Francis, H., Bile acid signaling and biliary functions. Acta Pharm Sin B 5 (2015), 123–128.
    • (2015) Acta Pharm Sin B , vol.5 , pp. 123-128
    • Jones, H.1    Alpini, G.2    Francis, H.3
  • 71
    • 85016475353 scopus 로고    scopus 로고
    • Old and new treatments for primary biliary cholangitis
    • Chascsa, D., Carey, E.J., Lindor, K.D., Old and new treatments for primary biliary cholangitis. Liver Int 37 (2017), 490–499.
    • (2017) Liver Int , vol.37 , pp. 490-499
    • Chascsa, D.1    Carey, E.J.2    Lindor, K.D.3
  • 73
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • Rodrigues, C., Fan, G., Ma, X., Kren, B.T., Steer, C.J., A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Investig, 101, 1998, 2790.
    • (1998) J Clin Investig , vol.101 , pp. 2790
    • Rodrigues, C.1    Fan, G.2    Ma, X.3    Kren, B.T.4    Steer, C.J.5
  • 74
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid
    • Calmus, Y., Gane, P., Rouger, P., Poupon, R., Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 11 (1990), 12–15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 76
    • 0037101810 scopus 로고    scopus 로고
    • 6α-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
    • Pellicciari, R., Fiorucci, S., Camaioni, E., Clerici, C., Costantino, G., Maloney, P.R., et al. 6α-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 45 (2002), 3569–3572.
    • (2002) J Med Chem , vol.45 , pp. 3569-3572
    • Pellicciari, R.1    Fiorucci, S.2    Camaioni, E.3    Clerici, C.4    Costantino, G.5    Maloney, P.R.6
  • 79
    • 85027481609 scopus 로고    scopus 로고
    • Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection
    • Bowlus, C.L., Obeticholic acid for the treatment of primary biliary cholangitis in adult patients: clinical utility and patient selection. Hepat Med 8 (2016), 89–95.
    • (2016) Hepat Med , vol.8 , pp. 89-95
    • Bowlus, C.L.1
  • 80
    • 85002878112 scopus 로고    scopus 로고
    • Novel therapeutics for primary biliary cholangitis: Toward a disease-stage-based approach
    • Mousa, H.S., Carbone, M., Malinverno, F., Ronca, V., Gershwin, M.E., Invernizzi, P., Novel therapeutics for primary biliary cholangitis: Toward a disease-stage-based approach. Autoimmun Rev 15 (2016), 870–876.
    • (2016) Autoimmun Rev , vol.15 , pp. 870-876
    • Mousa, H.S.1    Carbone, M.2    Malinverno, F.3    Ronca, V.4    Gershwin, M.E.5    Invernizzi, P.6
  • 81
    • 85013216661 scopus 로고    scopus 로고
    • Novel treatment strategies for primary biliary cholangitis
    • Pares, A., Novel treatment strategies for primary biliary cholangitis. Semin Liver Dis 37 (2017), 60–72.
    • (2017) Semin Liver Dis , vol.37 , pp. 60-72
    • Pares, A.1
  • 82
    • 84958933959 scopus 로고    scopus 로고
    • Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis
    • Baghdasaryan, A., Fuchs, C.D., Österreicher, C.H., Lemberger, U.J., Halilbasic, E., Påhlman, I., et al. Inhibition of intestinal bile acid absorption improves cholestatic liver and bile duct injury in a mouse model of sclerosing cholangitis. J Hepatol 64 (2016), 674–681.
    • (2016) J Hepatol , vol.64 , pp. 674-681
    • Baghdasaryan, A.1    Fuchs, C.D.2    Österreicher, C.H.3    Lemberger, U.J.4    Halilbasic, E.5    Påhlman, I.6
  • 83
    • 85001073693 scopus 로고    scopus 로고
    • Metabolic preconditioning protects BSEP/ABCB11 −/− mice against cholestatic liver injury
    • Fuchs, C.D., Paumgartner, G., Wahlström, A., Schwabl, P., Reiberger, T., Leditznig, N., et al. Metabolic preconditioning protects BSEP/ABCB11 −/− mice against cholestatic liver injury. J Hepatol 66 (2017), 95–101.
    • (2017) J Hepatol , vol.66 , pp. 95-101
    • Fuchs, C.D.1    Paumgartner, G.2    Wahlström, A.3    Schwabl, P.4    Reiberger, T.5    Leditznig, N.6
  • 84
    • 85014715522 scopus 로고    scopus 로고
    • New therapeutic concepts in bile acid transport and signaling for management of cholestasis
    • Trauner, M., Fuchs, C.D., Halilbasic, E., Paumgartner, G., New therapeutic concepts in bile acid transport and signaling for management of cholestasis. Hepatology 65:4 (2017), 1393–1404.
    • (2017) Hepatology , vol.65 , Issue.4 , pp. 1393-1404
    • Trauner, M.1    Fuchs, C.D.2    Halilbasic, E.3    Paumgartner, G.4
  • 85
  • 86
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K.S., Manichanh, C., et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464 (2010), 59–65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3    Arumugam, M.4    Burgdorf, K.S.5    Manichanh, C.6
  • 87
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500 (2013), 541–546.
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1    Nielsen, T.2    Qin, J.3    Prifti, E.4    Hildebrand, F.5    Falony, G.6
  • 88
    • 20044377582 scopus 로고    scopus 로고
    • Effects of biodiversity on ecosystem functioning: a consensus of current knowledge
    • Hooper, D.U., Chapin, F., Ewel, J., Hector, A., Inchausti, P., Lavorel, S., et al. Effects of biodiversity on ecosystem functioning: a consensus of current knowledge. Ecol Monogr 75 (2005), 3–35.
    • (2005) Ecol Monogr , vol.75 , pp. 3-35
    • Hooper, D.U.1    Chapin, F.2    Ewel, J.3    Hector, A.4    Inchausti, P.5    Lavorel, S.6
  • 89
    • 84994553261 scopus 로고    scopus 로고
    • Gut microbiome and liver diseases
    • Tilg, H., Cani, P.D., Mayer, E.A., Gut microbiome and liver diseases. Gut 65 (2016), 2035–2044.
    • (2016) Gut , vol.65 , pp. 2035-2044
    • Tilg, H.1    Cani, P.D.2    Mayer, E.A.3
  • 90
    • 84992597804 scopus 로고    scopus 로고
    • A clinical update on the significance of the gut microbiota in systemic autoimmunity
    • Rosser, E.C., Mauri, C., A clinical update on the significance of the gut microbiota in systemic autoimmunity. J Autoimmun 74 (2016), 85–93.
    • (2016) J Autoimmun , vol.74 , pp. 85-93
    • Rosser, E.C.1    Mauri, C.2
  • 91
    • 85016062284 scopus 로고    scopus 로고
    • Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases
    • [Epub ahead of print]
    • Chen, B., Sun, L., Zhang, X., Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases. J Autoimmun, 2017 [Epub ahead of print].
    • (2017) J Autoimmun
    • Chen, B.1    Sun, L.2    Zhang, X.3
  • 93
    • 84941260183 scopus 로고    scopus 로고
    • Rheumatoid arthritis-celiac disease relationship: joints get that gut feeling
    • Lerner, A., Matthias, T., Rheumatoid arthritis-celiac disease relationship: joints get that gut feeling. Autoimmun Rev 14 (2015), 1038–1047.
    • (2015) Autoimmun Rev , vol.14 , pp. 1038-1047
    • Lerner, A.1    Matthias, T.2
  • 94
    • 84937426489 scopus 로고    scopus 로고
    • The mucosa-associated microbiota of PSC patients is characterized by low diversity and low abundance of uncultured Clostridiales II
    • Rossen, N.G., Fuentes, S., Boonstra, K., D'Haens, G.R., Heilig, H.G., Zoetendal, E.G., et al. The mucosa-associated microbiota of PSC patients is characterized by low diversity and low abundance of uncultured Clostridiales II. J Crohns Colitis, 2015, jju023.
    • (2015) J Crohns Colitis
    • Rossen, N.G.1    Fuentes, S.2    Boonstra, K.3    D'Haens, G.R.4    Heilig, H.G.5    Zoetendal, E.G.6
  • 95
    • 84977664082 scopus 로고    scopus 로고
    • Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis
    • Lv, L.X., Fang, D.Q., Shi, D., Chen, D.Y., Yan, R., Zhu, Y.X., et al. Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis. Environ Microbiol 18 (2016), 2272–2286.
    • (2016) Environ Microbiol , vol.18 , pp. 2272-2286
    • Lv, L.X.1    Fang, D.Q.2    Shi, D.3    Chen, D.Y.4    Yan, R.5    Zhu, Y.X.6
  • 96
    • 85027483143 scopus 로고    scopus 로고
    • Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy
    • [gutjnl-2016-313332; Epub ahead of print]
    • Tang, R., Wei, Y., Li, Y., Chen, W., Chen, H., Wang, Q., et al. Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy. Gut, 2017 [gutjnl-2016-313332; Epub ahead of print].
    • (2017) Gut
    • Tang, R.1    Wei, Y.2    Li, Y.3    Chen, W.4    Chen, H.5    Wang, Q.6
  • 97
    • 0025801063 scopus 로고
    • Biliary tract disease in rats with experimental small bowel bacterial overgrowth
    • Lichtman, S.N., Keku, J., Clark, R.L., Schwab, J.H., Sartor, R.B., Biliary tract disease in rats with experimental small bowel bacterial overgrowth. Hepatology 13 (1991), 766–772.
    • (1991) Hepatology , vol.13 , pp. 766-772
    • Lichtman, S.N.1    Keku, J.2    Clark, R.L.3    Schwab, J.H.4    Sartor, R.B.5
  • 98
    • 0027935792 scopus 로고
    • Small duct cholangitis induced byn-formyll-methioninel-leucinel-tyrosine in rats
    • Yamada, S., Ishii, M., Liang, L.S., Yamamoto, T., Toyota, T., Small duct cholangitis induced byn-formyll-methioninel-leucinel-tyrosine in rats. J Gastroenterol 29 (1994), 631–636.
    • (1994) J Gastroenterol , vol.29 , pp. 631-636
    • Yamada, S.1    Ishii, M.2    Liang, L.S.3    Yamamoto, T.4    Toyota, T.5
  • 99
    • 77950353635 scopus 로고    scopus 로고
    • Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation
    • Haruta, I., Kikuchi, K., Hashimoto, E., Nakamura, M., Miyakawa, H., Hirota, K., et al. Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation. Lab Invest 90 (2010), 577–588.
    • (2010) Lab Invest , vol.90 , pp. 577-588
    • Haruta, I.1    Kikuchi, K.2    Hashimoto, E.3    Nakamura, M.4    Miyakawa, H.5    Hirota, K.6
  • 100
    • 84952637577 scopus 로고    scopus 로고
    • Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis
    • Tabibian, J.H., O'hara, S.P., Trussoni, C.E., Tietz, P.S., Splinter, P.L., Mounajjed, T., et al. Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis. Hepatology 63 (2016), 185–196.
    • (2016) Hepatology , vol.63 , pp. 185-196
    • Tabibian, J.H.1    O'hara, S.P.2    Trussoni, C.E.3    Tietz, P.S.4    Splinter, P.L.5    Mounajjed, T.6
  • 101
    • 85006868969 scopus 로고    scopus 로고
    • The microbiome and primary sclerosing cholangitis. seminars in liver disease
    • Thieme Medical Publishers
    • Ali, A.H., Carey, E.J., Lindor, K.D., The microbiome and primary sclerosing cholangitis. seminars in liver disease. 2016, Thieme Medical Publishers, 340–348.
    • (2016) , pp. 340-348
    • Ali, A.H.1    Carey, E.J.2    Lindor, K.D.3
  • 102
    • 85006883458 scopus 로고    scopus 로고
    • Primary biliary cirrhosis and the microbiome
    • Quigley, E.M., Primary biliary cirrhosis and the microbiome. Semin Liver Dis 36 (2016), 349–353.
    • (2016) Semin Liver Dis , vol.36 , pp. 349-353
    • Quigley, E.M.1
  • 103
    • 84978893113 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis: 50 years of a gut–liver relationship and still no love?
    • [gutjnl-2016-312137]
    • Karlsen, T.H., Primary sclerosing cholangitis: 50 years of a gut–liver relationship and still no love?. Gut, 2016 [gutjnl-2016-312137].
    • (2016) Gut
    • Karlsen, T.H.1
  • 104
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper, L.V., Littman, D.R., Macpherson, A.J., Interactions between the microbiota and the immune system. Science 336 (2012), 1268–1273.
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 105
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., Medzhitov, R., Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118 (2004), 229–241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 106
    • 84904414417 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies
    • Tabibian, J.H., O'hara, S.P., Lindor, K.D., Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies. Scand J Gastroenterol 49 (2014), 901–908.
    • (2014) Scand J Gastroenterol , vol.49 , pp. 901-908
    • Tabibian, J.H.1    O'hara, S.P.2    Lindor, K.D.3
  • 107
    • 0037065563 scopus 로고    scopus 로고
    • Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease
    • Grant, A.J., Lalor, P.F., Salmi, M., Jalkanen, S., Adams, D.H., Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease. Lancet 359 (2002), 150–157.
    • (2002) Lancet , vol.359 , pp. 150-157
    • Grant, A.J.1    Lalor, P.F.2    Salmi, M.3    Jalkanen, S.4    Adams, D.H.5
  • 108
    • 10644245899 scopus 로고    scopus 로고
    • Hepatic endothelial CCL25 mediates the recruitment of CCR9 + gut-homing lymphocytes to the liver in primary sclerosing cholangitis
    • Eksteen, B., Grant, A.J., Miles, A., Curbishley, S.M., Lalor, P.F., Hübscher, S.G., et al. Hepatic endothelial CCL25 mediates the recruitment of CCR9 + gut-homing lymphocytes to the liver in primary sclerosing cholangitis. J Exp Med 200 (2004), 1511–1517.
    • (2004) J Exp Med , vol.200 , pp. 1511-1517
    • Eksteen, B.1    Grant, A.J.2    Miles, A.3    Curbishley, S.M.4    Lalor, P.F.5    Hübscher, S.G.6
  • 109
    • 84893667590 scopus 로고    scopus 로고
    • CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice
    • Seidel, D., Eickmeier, I., Kühl, A.A., Hamann, A., Loddenkemper, C., Schott, E., CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice. Hepatology 59 (2014), 601–611.
    • (2014) Hepatology , vol.59 , pp. 601-611
    • Seidel, D.1    Eickmeier, I.2    Kühl, A.A.3    Hamann, A.4    Loddenkemper, C.5    Schott, E.6
  • 110
    • 84952908271 scopus 로고    scopus 로고
    • The critical role of toll-like receptors–from microbial recognition to autoimmunity: a comprehensive review
    • Jimenez-Dalmaroni, M.J., Gerswhin, M.E., Adamopoulos, I.E., The critical role of toll-like receptors–from microbial recognition to autoimmunity: a comprehensive review. Autoimmun Rev 15 (2016), 1–8.
    • (2016) Autoimmun Rev , vol.15 , pp. 1-8
    • Jimenez-Dalmaroni, M.J.1    Gerswhin, M.E.2    Adamopoulos, I.E.3
  • 111
    • 84879938335 scopus 로고    scopus 로고
    • Role of autoimmunity in primary biliary cirrhosis
    • Shi, T.-Y., Zhang, F.-C., Role of autoimmunity in primary biliary cirrhosis. World J Gastroenterol 18 (2012), 7141–7148.
    • (2012) World J Gastroenterol , vol.18 , pp. 7141-7148
    • Shi, T.-Y.1    Zhang, F.-C.2
  • 112
    • 84988421413 scopus 로고    scopus 로고
    • Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance
    • Bae, H.R., Leung, P.S., Tsuneyama, K., Valencia, J.C., Hodge, D.L., Kim, S., et al. Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance. Hepatology 64 (2016), 1189–1201.
    • (2016) Hepatology , vol.64 , pp. 1189-1201
    • Bae, H.R.1    Leung, P.S.2    Tsuneyama, K.3    Valencia, J.C.4    Hodge, D.L.5    Kim, S.6
  • 113
    • 85017163452 scopus 로고    scopus 로고
    • The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis
    • Shuai, Z., Wang, J., Badamagunta, M., Choi, J., Yang, G., Zhang, W., et al. The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis. Hepatology 65:5 (2017), 1670–1682.
    • (2017) Hepatology , vol.65 , Issue.5 , pp. 1670-1682
    • Shuai, Z.1    Wang, J.2    Badamagunta, M.3    Choi, J.4    Yang, G.5    Zhang, W.6
  • 114
    • 84922223191 scopus 로고    scopus 로고
    • Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis
    • Zhang, J., Zhang, W., Leung, P.S., Bowlus, C.L., Dhaliwal, S., Coppel, R.L., et al. Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis. Hepatology 60 (2014), 1708–1716.
    • (2014) Hepatology , vol.60 , pp. 1708-1716
    • Zhang, J.1    Zhang, W.2    Leung, P.S.3    Bowlus, C.L.4    Dhaliwal, S.5    Coppel, R.L.6
  • 116
    • 84905011139 scopus 로고    scopus 로고
    • Breach of tolerance: primary biliary cirrhosis. Seminars in liver disease
    • Thieme Medical Publishers
    • Wang, L., Wang, F.-S., Chang, C., Gershwin, M.E., Breach of tolerance: primary biliary cirrhosis. Seminars in liver disease. 2014, Thieme Medical Publishers, 297–317.
    • (2014) , pp. 297-317
    • Wang, L.1    Wang, F.-S.2    Chang, C.3    Gershwin, M.E.4
  • 117
    • 85006054017 scopus 로고    scopus 로고
    • Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis
    • Chung, B.K., Guevel, B.T., Reynolds, G.M., Udatha, D.G., EKK, Henriksen, Stamataki, Z., et al. Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis. J Autoimmun 77 (2017), 45–54.
    • (2017) J Autoimmun , vol.77 , pp. 45-54
    • Chung, B.K.1    Guevel, B.T.2    Reynolds, G.M.3    Udatha, D.G.4    EKK, H.5    Stamataki, Z.6
  • 118
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4 + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • Sakaguchi, S., Naturally arising CD4 + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 22 (2004), 531–562.
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 119
    • 33748309351 scopus 로고    scopus 로고
    • Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M
    • Harada, K., Isse, K., Sato, Y., Ozaki, S., Nakanuma, Y., Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK-M. Liver Int 26 (2006), 935–942.
    • (2006) Liver Int , vol.26 , pp. 935-942
    • Harada, K.1    Isse, K.2    Sato, Y.3    Ozaki, S.4    Nakanuma, Y.5
  • 120
    • 0036246857 scopus 로고    scopus 로고
    • Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis
    • Kita, H., Matsumura, S., He, X.-S., Ansari, A.A., Lian, Z.-X., Van de Water, J., et al. Quantitative and functional analysis of PDC-E2–specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest 109 (2002), 1231–1240.
    • (2002) J Clin Invest , vol.109 , pp. 1231-1240
    • Kita, H.1    Matsumura, S.2    He, X.-S.3    Ansari, A.A.4    Lian, Z.-X.5    Van de Water, J.6
  • 121
    • 0025340632 scopus 로고
    • Reactivity of primary biliary cirrhosis sera with Escherichia coli dihydrolipoamide acetyltransferase (E2p): characterization of the main immunogenic region
    • Fussey, S., Ali, S.T., Guest, J.R., James, O., Bassendine, M.F., Yeaman, S.J., Reactivity of primary biliary cirrhosis sera with Escherichia coli dihydrolipoamide acetyltransferase (E2p): characterization of the main immunogenic region. Proc Natl Acad Sci 87 (1990), 3987–3991.
    • (1990) Proc Natl Acad Sci , vol.87 , pp. 3987-3991
    • Fussey, S.1    Ali, S.T.2    Guest, J.R.3    James, O.4    Bassendine, M.F.5    Yeaman, S.J.6
  • 123
    • 77953718694 scopus 로고    scopus 로고
    • p-ANCAs in autoimmune liver disorders recognise human β-tubulin isotype 5 and cross-react with microbial protein FtsZ
    • Terjung, B., Söhne, J., Lechtenberg, B., Gottwein, J., Muennich, M., Herzog, V., et al. p-ANCAs in autoimmune liver disorders recognise human β-tubulin isotype 5 and cross-react with microbial protein FtsZ. Gut 59 (2010), 808–816.
    • (2010) Gut , vol.59 , pp. 808-816
    • Terjung, B.1    Söhne, J.2    Lechtenberg, B.3    Gottwein, J.4    Muennich, M.5    Herzog, V.6
  • 124
    • 77953785070 scopus 로고    scopus 로고
    • The metabolic life and times of a T-cell
    • Michalek, R.D., Rathmell, J.C., The metabolic life and times of a T-cell. Immunol Rev 236 (2010), 190–202.
    • (2010) Immunol Rev , vol.236 , pp. 190-202
    • Michalek, R.D.1    Rathmell, J.C.2
  • 125
    • 27744519400 scopus 로고    scopus 로고
    • Fuel feeds function: energy metabolism and the T-cell response
    • Fox, C.J., Hammerman, P.S., Thompson, C.B., Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 5 (2005), 844–852.
    • (2005) Nat Rev Immunol , vol.5 , pp. 844-852
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 126
    • 0141645569 scopus 로고    scopus 로고
    • Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E1 and E2 production by intestinal myofibroblasts
    • Willemsen, L., Koetsier, M., Van Deventer, S., Van Tol, E., Short chain fatty acids stimulate epithelial mucin 2 expression through differential effects on prostaglandin E1 and E2 production by intestinal myofibroblasts. Gut 52 (2003), 1442–1447.
    • (2003) Gut , vol.52 , pp. 1442-1447
    • Willemsen, L.1    Koetsier, M.2    Van Deventer, S.3    Van Tol, E.4
  • 127
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa, Y., Obata, Y., Fukuda, S., Endo, T.A., Nakato, G., Takahashi, D., et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504 (2013), 446–450.
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3    Endo, T.A.4    Nakato, G.5    Takahashi, D.6
  • 128
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith, P.M., Howitt, M.R., Panikov, N., Michaud, M., Gallini, C.A., Bohlooly-y, M., et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341 (2013), 569–573.
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1    Howitt, M.R.2    Panikov, N.3    Michaud, M.4    Gallini, C.A.5    Bohlooly-y, M.6
  • 129
    • 42949171444 scopus 로고    scopus 로고
    • Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E 2 secretion in human peripheral blood mononuclear cells
    • Usami, M., Kishimoto, K., Ohata, A., Miyoshi, M., Aoyama, M., Fueda, Y., et al. Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E 2 secretion in human peripheral blood mononuclear cells. Nutr Res 28 (2008), 321–328.
    • (2008) Nutr Res , vol.28 , pp. 321-328
    • Usami, M.1    Kishimoto, K.2    Ohata, A.3    Miyoshi, M.4    Aoyama, M.5    Fueda, Y.6
  • 130
    • 84893859801 scopus 로고    scopus 로고
    • The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
    • Chang, P.V., Hao, L., Offermanns, S., Medzhitov, R., The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci 111 (2014), 2247–2252.
    • (2014) Proc Natl Acad Sci , vol.111 , pp. 2247-2252
    • Chang, P.V.1    Hao, L.2    Offermanns, S.3    Medzhitov, R.4
  • 131
    • 77956237892 scopus 로고    scopus 로고
    • Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
    • Singh, N., Thangaraju, M., Prasad, P.D., Martin, P.M., Lambert, N.A., Boettger, T., et al. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. J Biol Chem 285 (2010), 27601–27608.
    • (2010) J Biol Chem , vol.285 , pp. 27601-27608
    • Singh, N.1    Thangaraju, M.2    Prasad, P.D.3    Martin, P.M.4    Lambert, N.A.5    Boettger, T.6
  • 132
    • 67649311620 scopus 로고    scopus 로고
    • Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells
    • Eksteen, B., Mora, J.R., Haughton, E.L., Henderson, N.C., Lee–Turner, L., Villablanca, E.J., et al. Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells. Gastroenterology 137 (2009), 320–329.
    • (2009) Gastroenterology , vol.137 , pp. 320-329
    • Eksteen, B.1    Mora, J.R.2    Haughton, E.L.3    Henderson, N.C.4    Lee-Turner, L.5    Villablanca, E.J.6
  • 134
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331 (2011), 337–341.
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3    Imaoka, A.4    Kuwahara, T.5    Momose, Y.6
  • 135
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov, I.I., Atarashi, K., Manel, N., Brodie, E.L., Shima, T., Karaoz, U., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139 (2009), 485–498.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3    Brodie, E.L.4    Shima, T.5    Karaoz, U.6
  • 136
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31 (2009), 677–689.
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1    Rakotobe, S.2    Lécuyer, E.3    Mulder, I.4    Lan, A.5    Bridonneau, C.6
  • 137
    • 84943639694 scopus 로고    scopus 로고
    • Th17 cell induction by adhesion of microbes to intestinal epithelial cells
    • Atarashi, K., Tanoue, T., Ando, M., Kamada, N., Nagano, Y., Narushima, S., et al. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell 163 (2015), 367–380.
    • (2015) Cell , vol.163 , pp. 367-380
    • Atarashi, K.1    Tanoue, T.2    Ando, M.3    Kamada, N.4    Nagano, Y.5    Narushima, S.6
  • 138
    • 84863981813 scopus 로고    scopus 로고
    • Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
    • Folseraas, T., Melum, E., Rausch, P., Juran, B.D., Ellinghaus, E., Shiryaev, A., et al. Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci. J Hepatol 57 (2012), 366–375.
    • (2012) J Hepatol , vol.57 , pp. 366-375
    • Folseraas, T.1    Melum, E.2    Rausch, P.3    Juran, B.D.4    Ellinghaus, E.5    Shiryaev, A.6
  • 139
    • 0000072924 scopus 로고
    • The liver in ulcerative colitis treatment of pericholangitis with tetracycline
    • Rankin, J., Boden, R., Goulston, S., Morrow, W., The liver in ulcerative colitis treatment of pericholangitis with tetracycline. Lancet 274 (1959), 1110–1112.
    • (1959) Lancet , vol.274 , pp. 1110-1112
    • Rankin, J.1    Boden, R.2    Goulston, S.3    Morrow, W.4
  • 140
    • 84887423367 scopus 로고    scopus 로고
    • Role of the microbiota and antibiotics in primary sclerosing cholangitis
    • Tabibian, J.H., Talwalkar, J.A., Lindor, K.D., Role of the microbiota and antibiotics in primary sclerosing cholangitis. Biomed Res Int, 2013, 2013.
    • (2013) Biomed Res Int , vol.2013
    • Tabibian, J.H.1    Talwalkar, J.A.2    Lindor, K.D.3
  • 141
    • 84965058071 scopus 로고    scopus 로고
    • Antibiotic use and its consequences for the normal microbiome
    • Blaser, M.J., Antibiotic use and its consequences for the normal microbiome. Science 352 (2016), 544–545.
    • (2016) Science , vol.352 , pp. 544-545
    • Blaser, M.J.1
  • 142
    • 85021078907 scopus 로고    scopus 로고
    • Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents
    • Watanabe, M., Fukiya, S., Yokota, A., Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents. J Lipid Res 58:6 (2017), 1143–1152.
    • (2017) J Lipid Res , vol.58 , Issue.6 , pp. 1143-1152
    • Watanabe, M.1    Fukiya, S.2    Yokota, A.3
  • 143
    • 0033618443 scopus 로고    scopus 로고
    • Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholate
    • Bernstein, H., Payne, C.M., Bernstein, C., Schneider, J., Beard, S.E., Crowley, C.L., Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholate. Toxicol Lett 108 (1999), 37–46.
    • (1999) Toxicol Lett , vol.108 , pp. 37-46
    • Bernstein, H.1    Payne, C.M.2    Bernstein, C.3    Schneider, J.4    Beard, S.E.5    Crowley, C.L.6
  • 144
    • 84899128105 scopus 로고    scopus 로고
    • Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo
    • Cremers, C.M., Knoefler, D., Vitvitsky, V., Banerjee, R., Jakob, U., Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo. Proc Natl Acad Sci 111:16 (2014), E1610–E1619.
    • (2014) Proc Natl Acad Sci , vol.111 , Issue.16 , pp. E1610-E1619
    • Cremers, C.M.1    Knoefler, D.2    Vitvitsky, V.3    Banerjee, R.4    Jakob, U.5
  • 145
    • 0029909320 scopus 로고    scopus 로고
    • Role of the gut in the pathophysiology of extrahepatic biliary obstruction
    • Clements, W., Parks, R., Erwin, P., Halliday, M., Barr, J., Rowlands, B., Role of the gut in the pathophysiology of extrahepatic biliary obstruction. Gut 39 (1996), 587–593.
    • (1996) Gut , vol.39 , pp. 587-593
    • Clements, W.1    Parks, R.2    Erwin, P.3    Halliday, M.4    Barr, J.5    Rowlands, B.6
  • 146
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 103 (2006), 3920–3925.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.-K.3    Peng, L.4    Zhao, G.5    Downes, M.6
  • 147
    • 62949244071 scopus 로고    scopus 로고
    • Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium
    • D'Aldebert, E., Mve, M.J.B.B., Mergey, M., Wendum, D., Firrincieli, D., Coilly, A., et al. Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium. Gastroenterology 136 (2009), 1435–1443.
    • (2009) Gastroenterology , vol.136 , pp. 1435-1443
    • D'Aldebert, E.1    Mve, M.J.B.B.2    Mergey, M.3    Wendum, D.4    Firrincieli, D.5    Coilly, A.6
  • 148
    • 84930580832 scopus 로고    scopus 로고
    • Interactions between diet, bile acid metabolism, gut microbiota, and inflammatory bowel diseases
    • Devkota, S., Chang, E.B., Interactions between diet, bile acid metabolism, gut microbiota, and inflammatory bowel diseases. Dig Dis 33 (2015), 351–356.
    • (2015) Dig Dis , vol.33 , pp. 351-356
    • Devkota, S.1    Chang, E.B.2
  • 149
    • 84897927609 scopus 로고    scopus 로고
    • Listeria monocytogenes: survival and adaptation in the gastrointestinal tract
    • Gahan, C.G., Hill, C., Listeria monocytogenes: survival and adaptation in the gastrointestinal tract. Front Cell Infect Microbiol, 4, 2014, 9.
    • (2014) Front Cell Infect Microbiol , vol.4 , pp. 9
    • Gahan, C.G.1    Hill, C.2
  • 151
    • 0030028114 scopus 로고    scopus 로고
    • Tauroconjugation of cholic acid stimulates 7 alpha-dehydroxylation by fecal bacteria
    • Van Eldere, J., Celis, P., De Pauw, G., Lesaffre, E., Eyssen, H., Tauroconjugation of cholic acid stimulates 7 alpha-dehydroxylation by fecal bacteria. Appl Environ Microbiol 62 (1996), 656–661.
    • (1996) Appl Environ Microbiol , vol.62 , pp. 656-661
    • Van Eldere, J.1    Celis, P.2    De Pauw, G.3    Lesaffre, E.4    Eyssen, H.5
  • 152
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • Ridlon, J.M., Kang, D.-J., Hylemon, P.B., Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47 (2006), 241–259.
    • (2006) J Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.-J.2    Hylemon, P.B.3
  • 153
    • 84455192400 scopus 로고    scopus 로고
    • Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium
    • Ridlon, J.M., Hylemon, P.B., Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium. J Lipid Res 53 (2012), 66–76.
    • (2012) J Lipid Res , vol.53 , pp. 66-76
    • Ridlon, J.M.1    Hylemon, P.B.2
  • 154
    • 84991053856 scopus 로고    scopus 로고
    • Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
    • Wahlström, A., Sayin, S.I., Marschall, H.-U., Bäckhed, F., Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab 24 (2016), 41–50.
    • (2016) Cell Metab , vol.24 , pp. 41-50
    • Wahlström, A.1    Sayin, S.I.2    Marschall, H.-U.3    Bäckhed, F.4
  • 156
    • 84857787967 scopus 로고    scopus 로고
    • Hydroxysteroid dehydrogenases (HSDs) in bacteria–a bioinformatic perspective
    • Kisiela, M., Skarka, A., Ebert, B., Maser, E., Hydroxysteroid dehydrogenases (HSDs) in bacteria–a bioinformatic perspective. J Steroid Biochem Mol Biol 129 (2012), 31–46.
    • (2012) J Steroid Biochem Mol Biol , vol.129 , pp. 31-46
    • Kisiela, M.1    Skarka, A.2    Ebert, B.3    Maser, E.4
  • 157
    • 85014708925 scopus 로고    scopus 로고
    • Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease
    • Gonzalez, F.J., Jiang, C., Xie, C., Patterson, A.D., Intestinal Farnesoid X Receptor Signaling Modulates Metabolic Disease. Dig Dis 35 (2017), 178–184.
    • (2017) Dig Dis , vol.35 , pp. 178-184
    • Gonzalez, F.J.1    Jiang, C.2    Xie, C.3    Patterson, A.D.4
  • 158
    • 84905257719 scopus 로고    scopus 로고
    • Bile acid signaling in metabolic disease and drug therapy
    • Li, T., Chiang, J.Y., Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev 66 (2014), 948–983.
    • (2014) Pharmacol Rev , vol.66 , pp. 948-983
    • Li, T.1    Chiang, J.Y.2
  • 159
    • 84873342775 scopus 로고    scopus 로고
    • Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
    • Sayin, S.I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 17 (2013), 225–235.
    • (2013) Cell Metab , vol.17 , pp. 225-235
    • Sayin, S.I.1    Wahlström, A.2    Felin, J.3    Jäntti, S.4    Marschall, H.-U.5    Bamberg, K.6
  • 160
    • 37249015421 scopus 로고    scopus 로고
    • Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
    • Kim, I., Ahn, S.-H., Inagaki, T., Choi, M., Ito, S., Guo, G.L., et al. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 48 (2007), 2664–2672.
    • (2007) J Lipid Res , vol.48 , pp. 2664-2672
    • Kim, I.1    Ahn, S.-H.2    Inagaki, T.3    Choi, M.4    Ito, S.5    Guo, G.L.6
  • 161
    • 84898023722 scopus 로고    scopus 로고
    • Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice
    • Degirolamo, C., Rainaldi, S., Bovenga, F., Murzilli, S., Moschetta, A., Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice. Cell Rep 7 (2014), 12–18.
    • (2014) Cell Rep , vol.7 , pp. 12-18
    • Degirolamo, C.1    Rainaldi, S.2    Bovenga, F.3    Murzilli, S.4    Moschetta, A.5
  • 162
    • 84924225963 scopus 로고    scopus 로고
    • Changes in bile acids, FGF-19 and sterol absorption in response to bile salt hydrolase active L. reuteri NCIMB 30242
    • Martoni, C.J., Labbé, A., Ganopolsky, J.G., Prakash, S., Jones, M.L., Changes in bile acids, FGF-19 and sterol absorption in response to bile salt hydrolase active L. reuteri NCIMB 30242. Gut Microbes 6 (2015), 57–65.
    • (2015) Gut Microbes , vol.6 , pp. 57-65
    • Martoni, C.J.1    Labbé, A.2    Ganopolsky, J.G.3    Prakash, S.4    Jones, M.L.5
  • 163
    • 85019226548 scopus 로고    scopus 로고
    • First-in-human experience with LJN452, an orally available non-bile acid FXR agonist, demonstrates potent activation of FXR in healthy subjects
    • Wiley-Blackwell 111 River St, Hoboken 07030-5774, NJ USA
    • Badman, M.K., Desai, S., Laffitte, B., Decristofaro, M., Lin, T., Chen, J., et al. First-in-human experience with LJN452, an orally available non-bile acid FXR agonist, demonstrates potent activation of FXR in healthy subjects. Hepatology, 2016, Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 16A-7A.
    • (2016) Hepatology , pp. 16A-7A
    • Badman, M.K.1    Desai, S.2    Laffitte, B.3    Decristofaro, M.4    Lin, T.5    Chen, J.6
  • 164
    • 85027487773 scopus 로고    scopus 로고
    • The non-steroidal Fxr agonist Gs-9674 reduces liver fibrosis and ameliorates portal hypertension in a rat nash model
    • Schwabl, P., Hambruch, E., Supper, P., Burnet, M., Peck-Radosavljevic, M., Reiberger, T., et al. The non-steroidal Fxr agonist Gs-9674 reduces liver fibrosis and ameliorates portal hypertension in a rat nash model. J Hepatol 64:2 (2016), S165–S166.
    • (2016) J Hepatol , vol.64 , Issue.2 , pp. S165-S166
    • Schwabl, P.1    Hambruch, E.2    Supper, P.3    Burnet, M.4    Peck-Radosavljevic, M.5    Reiberger, T.6
  • 165
    • 80053334403 scopus 로고    scopus 로고
    • Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/−(Abcb4 −/−) mouse cholangiopathy model by promoting biliary HCO 3 − output
    • Baghdasaryan, A., Claudel, T., Gumhold, J., Silbert, D., Adorini, L., Roda, A., et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/−(Abcb4 −/−) mouse cholangiopathy model by promoting biliary HCO 3 − output. Hepatology 54 (2011), 1303–1312.
    • (2011) Hepatology , vol.54 , pp. 1303-1312
    • Baghdasaryan, A.1    Claudel, T.2    Gumhold, J.3    Silbert, D.4    Adorini, L.5    Roda, A.6
  • 166
    • 84941338314 scopus 로고    scopus 로고
    • Impaired itching perception in murine models of cholestasis is supported by dysregulation of GPBAR1 signaling
    • Cipriani, S., Renga, B., D'Amore, C., Simonetti, M., De Tursi, A.A., Carino, A., et al. Impaired itching perception in murine models of cholestasis is supported by dysregulation of GPBAR1 signaling. PLoS One, 10, 2015, e0129866.
    • (2015) PLoS One , vol.10
    • Cipriani, S.1    Renga, B.2    D'Amore, C.3    Simonetti, M.4    De Tursi, A.A.5    Carino, A.6
  • 167
    • 84958163560 scopus 로고    scopus 로고
    • NGM282, a novel variant of FGF-19, demonstrates biologic activity in primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid: results of a phase 2 multicenter, randomized, double blinded, placebo controlled trial
    • Mayo, M.J., Wigg, A.J., Roberts, S.K., Arnold, H., Hassanein, T.I., Leggett, B.A., et al. NGM282, a novel variant of FGF-19, demonstrates biologic activity in primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid: results of a phase 2 multicenter, randomized, double blinded, placebo controlled trial. Hepatology 62 (2015), 263A–264A.
    • (2015) Hepatology , vol.62 , pp. 263A-264A
    • Mayo, M.J.1    Wigg, A.J.2    Roberts, S.K.3    Arnold, H.4    Hassanein, T.I.5    Leggett, B.A.6
  • 168
    • 85027482773 scopus 로고    scopus 로고
    • Development of a new hepatoprotective and proregenerative molecule based on fibroblast growth factor 15/19
    • Álvarez-Sola, G., Uriarte, I., Latasa, M., Elizalde, M., Urtasun, R., Rodríguez-Ortigosa, C., et al. Development of a new hepatoprotective and proregenerative molecule based on fibroblast growth factor 15/19. J Hepatol, 64, 2016, S184.
    • (2016) J Hepatol , vol.64 , pp. S184
    • Álvarez-Sola, G.1    Uriarte, I.2    Latasa, M.3    Elizalde, M.4    Urtasun, R.5    Rodríguez-Ortigosa, C.6
  • 170
    • 84924495097 scopus 로고    scopus 로고
    • A prospective randomized controlled study of long-term combination therapy using ursodeoxycholic acid and bezafibrate in patients with primary biliary cirrhosis and dyslipidemia
    • Hosonuma, K., Sato, K., Yamazaki, Y., Yanagisawa, M., Hashizume, H., Horiguchi, N., et al. A prospective randomized controlled study of long-term combination therapy using ursodeoxycholic acid and bezafibrate in patients with primary biliary cirrhosis and dyslipidemia. Am J Gastroenterol 110 (2015), 423–431.
    • (2015) Am J Gastroenterol , vol.110 , pp. 423-431
    • Hosonuma, K.1    Sato, K.2    Yamazaki, Y.3    Yanagisawa, M.4    Hashizume, H.5    Horiguchi, N.6
  • 171
    • 85016591179 scopus 로고    scopus 로고
    • Clarity: a phase 2, randomized, double-blind, placebo-controlled study of Lopixibat chloride (formerly Lum001), a novel apical sodium-dependent bile acid transporter inhibitor, in the treatment of primary biliary cirrhosis associated with itching
    • Mayo, M., Pockros, P., Jones, D., Bowlus, C., Levy, C., Patanwala, I., et al. Clarity: a phase 2, randomized, double-blind, placebo-controlled study of Lopixibat chloride (formerly Lum001), a novel apical sodium-dependent bile acid transporter inhibitor, in the treatment of primary biliary cirrhosis associated with itching. J Hepatol, 64, 2016, S197.
    • (2016) J Hepatol , vol.64 , pp. S197
    • Mayo, M.1    Pockros, P.2    Jones, D.3    Bowlus, C.4    Levy, C.5    Patanwala, I.6
  • 172
    • 85011850416 scopus 로고    scopus 로고
    • Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study
    • Hegade, V.S., Kendrick, S.F., Dobbins, R.L., Miller, S.R., Thompson, D., Richards, D., et al. Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study. Lancet 389:10074 (2017), 1114–1123.
    • (2017) Lancet , vol.389 , Issue.10074 , pp. 1114-1123
    • Hegade, V.S.1    Kendrick, S.F.2    Dobbins, R.L.3    Miller, S.R.4    Thompson, D.5    Richards, D.6
  • 173
    • 84956606917 scopus 로고    scopus 로고
    • Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice
    • Miethke, A.G., Zhang, W., Simmons, J., Taylor, A.E., Shi, T., Shanmukhappa, S.K., et al. Pharmacological inhibition of apical sodium-dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice. Hepatology 63 (2016), 512–523.
    • (2016) Hepatology , vol.63 , pp. 512-523
    • Miethke, A.G.1    Zhang, W.2    Simmons, J.3    Taylor, A.E.4    Shi, T.5    Shanmukhappa, S.K.6
  • 174
    • 84933178894 scopus 로고    scopus 로고
    • Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na +-taurocholate cotransporting polypeptide knockout mice
    • Slijepcevic, D., Kaufman, C., Wichers, C.G., Gilglioni, E.H., Lempp, F.A., Duijst, S., et al. Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na +-taurocholate cotransporting polypeptide knockout mice. Hepatology 62 (2015), 207–219.
    • (2015) Hepatology , vol.62 , pp. 207-219
    • Slijepcevic, D.1    Kaufman, C.2    Wichers, C.G.3    Gilglioni, E.H.4    Lempp, F.A.5    Duijst, S.6
  • 175
    • 85014647851 scopus 로고    scopus 로고
    • norUrsodeoxycholic acid (norUDCA) improves cholestasis in primary sclerosing cholangitis (PSC) independent of ursodeoxycholic acid (UDCA) pre-treatment and response
    • WB Saunders
    • Trauner, M.H., Fickert, P., Hirschfield, G., Denk, G., Altorjay, I., Marschall, H.-U., et al. norUrsodeoxycholic acid (norUDCA) improves cholestasis in primary sclerosing cholangitis (PSC) independent of ursodeoxycholic acid (UDCA) pre-treatment and response. Hepatology, 2016, WB Saunders, 111A-A.
    • (2016) Hepatology , pp. 111A-A
    • Trauner, M.H.1    Fickert, P.2    Hirschfield, G.3    Denk, G.4    Altorjay, I.5    Marschall, H.-U.6
  • 176
    • 67649205149 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: management of cholestatic liver diseases
    • Liver EAFTSOT, EASL clinical practice guidelines: management of cholestatic liver diseases. J Hepatol 51 (2009), 237–267.
    • (2009) J Hepatol , vol.51 , pp. 237-267
    • Liver EAFTSOT1
  • 177
    • 77957963502 scopus 로고    scopus 로고
    • The potent bile acid sequestrant colesevelam is not effective in cholestatic pruritus: results of a double-blind, randomized, placebo-controlled trial
    • Kuiper, E.M., van Erpecum, K.J., Beuers, U., Hansen, B.E., Thio, H.B., de Man, R.A., et al. The potent bile acid sequestrant colesevelam is not effective in cholestatic pruritus: results of a double-blind, randomized, placebo-controlled trial. Hepatology 52 (2010), 1334–1340.
    • (2010) Hepatology , vol.52 , pp. 1334-1340
    • Kuiper, E.M.1    van Erpecum, K.J.2    Beuers, U.3    Hansen, B.E.4    Thio, H.B.5    de Man, R.A.6
  • 178
    • 84963852038 scopus 로고    scopus 로고
    • Characterization of intestinal microbiota in ulcerative colitis patients with and without primary sclerosing cholangitis
    • Kevans, D., Tyler, A.D., Holm, K., Jørgensen, K.K., Vatn, M.H., Karlsen, T.H., et al. Characterization of intestinal microbiota in ulcerative colitis patients with and without primary sclerosing cholangitis. J Crohns Colitis 10 (2016), 330–337.
    • (2016) J Crohns Colitis , vol.10 , pp. 330-337
    • Kevans, D.1    Tyler, A.D.2    Holm, K.3    Jørgensen, K.K.4    Vatn, M.H.5    Karlsen, T.H.6
  • 179
    • 84959450854 scopus 로고    scopus 로고
    • The features of mucosa-associated microbiota in primary sclerosing cholangitis
    • Torres, J., Bao, X., Goel, A., Colombel, J.F., Pekow, J., Jabri, B., et al. The features of mucosa-associated microbiota in primary sclerosing cholangitis. Aliment Pharmacol Ther 43 (2016), 790–801.
    • (2016) Aliment Pharmacol Ther , vol.43 , pp. 790-801
    • Torres, J.1    Bao, X.2    Goel, A.3    Colombel, J.F.4    Pekow, J.5    Jabri, B.6
  • 180
    • 84959450356 scopus 로고    scopus 로고
    • The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
    • Kummen, M., Holm, K., Anmarkrud, J.A., Nygård, S., Vesterhus, M., Høivik, M.L., et al. The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. Gut 66:4 (2017), 611–619.
    • (2017) Gut , vol.66 , Issue.4 , pp. 611-619
    • Kummen, M.1    Holm, K.2    Anmarkrud, J.A.3    Nygård, S.4    Vesterhus, M.5    Høivik, M.L.6
  • 181
    • 84970044586 scopus 로고    scopus 로고
    • Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD
    • Sabino, J., Vieira-Silva, S., Machiels, K., Joossens, M., Falony, G., Ballet, V., et al. Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD. Gut 65 (2016), 1681–1689.
    • (2016) Gut , vol.65 , pp. 1681-1689
    • Sabino, J.1    Vieira-Silva, S.2    Machiels, K.3    Joossens, M.4    Falony, G.5    Ballet, V.6
  • 182
    • 85017020917 scopus 로고    scopus 로고
    • Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis
    • Rühlemann, M.C., Heinsen, F.-A., Zenouzi, R., Lieb, W., Franke, A., Schramm, C., Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis. Gut 66:4 (2017), 753–754.
    • (2017) Gut , vol.66 , Issue.4 , pp. 753-754
    • Rühlemann, M.C.1    Heinsen, F.-A.2    Zenouzi, R.3    Lieb, W.4    Franke, A.5    Schramm, C.6
  • 183
    • 84964846111 scopus 로고    scopus 로고
    • The gut-adherent microbiota of PSC–IBD is distinct to that of IBD
    • Quraishi, M.N., Sergeant, M., Kay, G., Iqbal, T., Chan, J., Constantinidou, C., et al. The gut-adherent microbiota of PSC–IBD is distinct to that of IBD. Gut 66 (2017), 386–388.
    • (2017) Gut , vol.66 , pp. 386-388
    • Quraishi, M.N.1    Sergeant, M.2    Kay, G.3    Iqbal, T.4    Chan, J.5    Constantinidou, C.6
  • 184
    • 0013816559 scopus 로고
    • Effect of long-term tetracycline therapy, steroid therapy and colectomy in pericholangitis associated with ulcerative colitis
    • Mistilis, S., Skyring, A., Goulston, S., Effect of long-term tetracycline therapy, steroid therapy and colectomy in pericholangitis associated with ulcerative colitis. Australas Ann Med 14 (1965), 286–294.
    • (1965) Australas Ann Med , vol.14 , pp. 286-294
    • Mistilis, S.1    Skyring, A.2    Goulston, S.3
  • 185
    • 0023846078 scopus 로고
    • Treatment of pruritus in primary biliary cirrhosis with rifampin: results of a double-blind, crossover, randomized trial
    • Ghent, C.N., Carruthers, S.G., Treatment of pruritus in primary biliary cirrhosis with rifampin: results of a double-blind, crossover, randomized trial. Gastroenterology 94 (1988), 488–493.
    • (1988) Gastroenterology , vol.94 , pp. 488-493
    • Ghent, C.N.1    Carruthers, S.G.2
  • 186
    • 0026548603 scopus 로고
    • Effects of long-term rifampicin administration in primary biliary cirrhosis
    • Bachs, L., Parés, A., Elena, M., Piera, C., Rodés, J., Effects of long-term rifampicin administration in primary biliary cirrhosis. Gastroenterology 102 (1992), 2077–2080.
    • (1992) Gastroenterology , vol.102 , pp. 2077-2080
    • Bachs, L.1    Parés, A.2    Elena, M.3    Piera, C.4    Rodés, J.5
  • 187
    • 0032135138 scopus 로고    scopus 로고
    • Case report: three paediatric cases of primary sclerosing cholangitis treated with ursodeoxycholic acid and sulphasalazine
    • Kozaiwa, K., Tajiri, H., Sawada, A., Tada, K., Etani, Y., Miki, K., et al. Case report: three paediatric cases of primary sclerosing cholangitis treated with ursodeoxycholic acid and sulphasalazine. J Gastroenterol Hepatol 13 (1998), 825–829.
    • (1998) J Gastroenterol Hepatol , vol.13 , pp. 825-829
    • Kozaiwa, K.1    Tajiri, H.2    Sawada, A.3    Tada, K.4    Etani, Y.5    Miki, K.6
  • 188
    • 33744801168 scopus 로고    scopus 로고
    • Therapeutic benefit of sulfasalazine for patients with primary sclerosing cholangitis
    • Tada, S., Ebinuma, H., Saito, H., Hibi, T., Therapeutic benefit of sulfasalazine for patients with primary sclerosing cholangitis. J Gastroenterol 41 (2006), 388–389.
    • (2006) J Gastroenterol , vol.41 , pp. 388-389
    • Tada, S.1    Ebinuma, H.2    Saito, H.3    Hibi, T.4
  • 189
    • 0031782677 scopus 로고    scopus 로고
    • Oral vancomycin: treatment of primary sclerosing cholangitis in children with inflammatory bowel disease
    • Cox, K.L., Cox, K.M., Oral vancomycin: treatment of primary sclerosing cholangitis in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 27 (1998), 580–583.
    • (1998) J Pediatr Gastroenterol Nutr , vol.27 , pp. 580-583
    • Cox, K.L.1    Cox, K.M.2
  • 190
    • 84874117027 scopus 로고    scopus 로고
    • Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis-a pilot study
    • Tabibian, J., Weeding, E., Jorgensen, R., Petz, J., Keach, J., Talwalkar, J.A., et al. Randomised clinical trial: vancomycin or metronidazole in patients with primary sclerosing cholangitis-a pilot study. Aliment Pharmacol Ther 37 (2013), 604–612.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 604-612
    • Tabibian, J.1    Weeding, E.2    Jorgensen, R.3    Petz, J.4    Keach, J.5    Talwalkar, J.A.6
  • 191
    • 10644269919 scopus 로고    scopus 로고
    • Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis: a randomized placebo-controlled trial
    • Färkkilä, M., Karvonen, A.L., Nurmi, H., Nuutinen, H., Taavitsainen, M., Pikkarainen, P., et al. Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis: a randomized placebo-controlled trial. Hepatology 40 (2004), 1379–1386.
    • (2004) Hepatology , vol.40 , pp. 1379-1386
    • Färkkilä, M.1    Karvonen, A.L.2    Nurmi, H.3    Nuutinen, H.4    Taavitsainen, M.5    Pikkarainen, P.6
  • 192
    • 37749028067 scopus 로고    scopus 로고
    • Azithromycin may reduce cholestasis in primary sclerosing cholangitis: a case report and serendipitous observation
    • Boner, A., Peroni, D., Bodini, A., Delaini, G., Piacentini, G., Azithromycin may reduce cholestasis in primary sclerosing cholangitis: a case report and serendipitous observation. Int J Immunopathol Pharmacol 20 (2007), 847–849.
    • (2007) Int J Immunopathol Pharmacol , vol.20 , pp. 847-849
    • Boner, A.1    Peroni, D.2    Bodini, A.3    Delaini, G.4    Piacentini, G.5
  • 193
    • 60749089231 scopus 로고    scopus 로고
    • Minocycline in the treatment of patients with primary sclerosing cholangitis: results of a pilot study
    • Silveira, M.G., Torok, N.J., Gossard, A.A., Keach, J.C., Jorgensen, R.A., Petz, J.L., et al. Minocycline in the treatment of patients with primary sclerosing cholangitis: results of a pilot study. Am J Gastroenterol 104 (2009), 83–88.
    • (2009) Am J Gastroenterol , vol.104 , pp. 83-88
    • Silveira, M.G.1    Torok, N.J.2    Gossard, A.A.3    Keach, J.C.4    Jorgensen, R.A.5    Petz, J.L.6
  • 194
    • 84901863080 scopus 로고    scopus 로고
    • Prospective clinical trial of rifaximin therapy for patients with primary sclerosing cholangitis
    • Tabibian, J.H., Gossard, A., El-Youssef, M., Eaton, J.E., Petz, J., Jorgensen, R., et al. Prospective clinical trial of rifaximin therapy for patients with primary sclerosing cholangitis. Am J Ther 24:1 (2017), e56–e63.
    • (2017) Am J Ther , vol.24 , Issue.1 , pp. e56-e63
    • Tabibian, J.H.1    Gossard, A.2    El-Youssef, M.3    Eaton, J.E.4    Petz, J.5    Jorgensen, R.6
  • 195
    • 62149093658 scopus 로고    scopus 로고
    • Probiotics in primary sclerosing cholangitis: a randomized placebo-controlled crossover pilot study
    • Vleggaar, F.P., Monkelbaan, J.F., van Erpecum, K.J., Probiotics in primary sclerosing cholangitis: a randomized placebo-controlled crossover pilot study. Eur J Gastroenterol Hepatol 20 (2008), 688–692.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 688-692
    • Vleggaar, F.P.1    Monkelbaan, J.F.2    van Erpecum, K.J.3
  • 196
    • 84866688800 scopus 로고    scopus 로고
    • Successful treatment of primary sclerosing cholangitis with a steroid and a probiotic
    • Shimizu, M., Iwasaki, H., Mase, S., Yachie, A., Successful treatment of primary sclerosing cholangitis with a steroid and a probiotic. Case Rep Gastroenterol 6 (2012), 249–253.
    • (2012) Case Rep Gastroenterol , vol.6 , pp. 249-253
    • Shimizu, M.1    Iwasaki, H.2    Mase, S.3    Yachie, A.4


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