27-Hydroxycholesterol: Production rates in normal human subjects

Journal of Lipid Research

Volumn 40, Issue 7, 1999, Pages 1194-1199

  Duane, William C ^a   Javitt, Norman B ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; Bile acids and salts; Cholelithiasis; Cholesterol; Oxysterols

Indexed keywords

26 HYDROXYCHOLESTEROL; BILE ACID; CARBON 14; CHENODEOXYCHOLIC ACID; CHOLIC ACID; DEUTERIUM; STEROL; TRITIUM; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BILE ACID SYNTHESIS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROXYLATION; MACROPHAGE; NORMAL HUMAN; PRIORITY JOURNAL; STEROL SYNTHESIS; VASCULAR ENDOTHELIUM;

ADULT; AGED; BILE ACIDS AND SALTS; HUMANS; HYDROXYCHOLESTEROLS; MALE; MIDDLE AGED; REFERENCE VALUES;

EID: 0032769064     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Princen, H. M. G., S. M. Post, and J. Twisk. 1997. Regulation of bile acid biosynthesis. Curr. Pharm. Des. 3: 59-84.
2. Axelson, M., and J. Sjovall. 1990. Potential bile acid precursors in plasma - possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man. J. Steroid Biochem. 36: 631-640.
3. Vlahcevic, Z. R., R. T. Stravitz, D. M. Heuman, P. B. Hylemon, and W. M. Pandak. 1997. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. Gastroenterology. 113: 1949-1957.
4. Twisk, J., M. F. M. Hoekman, W. H. Mager, A. F. M. Moorman, P. A. J. de Boer, L. Scheja, H. M. G. Princen, and R. Gebhardt. 1995. Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus. J. Clin. Invest. 95: 1235-1243.
5. Holmberg-Betsholtz, I., E. Lund, I. Bjorkhem, and K. Wikvall. 1993. Sterol 27-hydroxylase in bile acid biosynthesis. Mechanism of oxidation of 5β-cholestane-3α,7α,12α,27-tetrol into 3α,7α,12α-trihydroxy-5β-cholestanoic acid. J. Biol. Chem. 268: 11079-11085.
6. Bjorkhem, I., O. Andersson, U. Diczfalusy, B. Sevastik, R. J. Xiu, C. G. Duan, and E. Lund. 1994. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Proc. Natl. Acad. Sci. USA. 91: 8592-8596.
7. 3H. J. Clin. Invest. 51: 112-117.
8. Swell, L., J. Gustafsson, C. C. Schwartz, L. G. Halloran, H. Danielsson, and Z. R. Vlahcevic. 1980. An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man. J. Lipid Res. 21: 455-466.
9. 3H]26-hydroxycholesterol. Hepatology. 2: 59-66.
10. Reiss, A. B., K. O. Martin, N. B. Javitt, D. W. Martin, E. A. Grossi, and A. C. Galloway. 1994. Sterol 27-hydroxylase: high levels of activity in vascular endothelium. J. Lipid Res. 35: 1026-1030.
11. Axelson, M., B. Mork, and J. Sjovall. 1988. Occurrence of 3β-hydroxy-5-cholestenoic acid, 3β,7α-dihydroxy-5-cholestenoic acid, and 7α-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood. J. Lipid Res. 29: 629-641.
12. Javitt, N. B., E. Kok, S. Burstein, B. Cohen, and J. Kutscher. 1981. 26-Hydroxycholesterol. Identification and quantitation in human serum. J. Biol. Chem. 256: 12644-12646.
13. Javitt, N. B. 1994. Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. FASEB J. 8: 1308-1311.
14. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. L. Witztum. 1989. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320: 915-924.
15. Chisolm, G. M., G. P. Ma, K. C. Irwin, L. L. Martin, K. G. Gunderson, L. F. Linberg, D. W. Morel, and P. E. Dicorleto. 1994. 7β-Hydroperoxycholest-5-en-3β-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein. Proc. Natl. Acad. Sci. USA. 91: 11452-11456.
16. Smith, L. L., and J. E. van Lier. 1970. Sterol metabolism: Part 9. 26-Hydroxycholesterol. Levels in the human aorta. Atherosclerosis. 12: 1-14.
17. Ballantyne, C. M., G. L. Vega, C. East, G. Richards, and S. M. Grundy. 1987. Low-density lipoprotein metabolism in cerebrotendinous xanthomatosis. Metab. Clin. Exp. 36: 270-276.
18. Cali, J. J., C. Hsieh, U. Francke, and D. W. Russell. 1991. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. J. Biol. Chem. 266: 7779-7783.
19. Schwarz, M., E. G. Lund, D. R. Setchell, H. J. Kayden, J. E. Zerwekh, I. Bjorkhem, J. Herz, and D. W. Russell. 1996. Disruption of cholesterol 7a-hydroxylase gene in mice: II. Bile acid deficiency is overcome by induction of oxysterol 7α-hydroxylase. J. Biol. Chem. 271: 18024-18031.
20. Setchell, D. R., M. Schwarz, N. C. O'Connell, E. G. Lund, D. L. Davis, R. Lathe, G. R. Thompson, R. W. Tyson, R. J. Sokol, and D. W. Russell. 1998. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7α-hydroxylase gene causes severe neonatal liver disease. J. Clin. Invest. 102: 1690-1703.
21. 27-sterols in human fetal liver. J. Lipid Res. 27: 801-806.
22. Collins, J. C., P. Altman, K. O. Martin, and N. B. Javitt. 1994. Neonatal cholestatic syndromes: molecular basis for transient or "physiologic" cholestasis. Hepatology. 20: 340A(Abstr.)
23. Lund, E., O. Andersson, J. Zhang, A. Babiker, G. Ahlborg, U. Diczfalusy, K. Einarsson, J. Sjovall, and I. Bjorkhem. 1996. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans. Arterioscler. Thromb. Vasc. Biol. 16: 208-212.
24. Gurpide, E., J. Mann, and S. Lieberman. 1963. Analysis of open systems of multiple pools by administration of tracers at a constant rate or as a single dose as illustrated by problems involving steroid hormones. J. Clin. Endocrinol. Metab. 23: 1155-1176.
25. Duane, W. C. 1978. Simulation of the defect of bile acid metabolism associated with cholesterol cholelithiasis by sorbitol ingestion in man. J. Lab. Clin. Med. 91: 969-978.
26. Duane, W. C. 1995. Abnormal bile acid absorption in familial hypertriglyceridemia. J. Lipid Res. 36: 96-107.
27. Duane, W. C. 1997. Measurement of bile acid synthesis by three different methods in hypertriglyceridemic and control subjects. J. Lipid Res. 38: 183-188.
28. D'Ambra, T. E., N. B. Javitt, K. Nakanishi, and T. Warchol. 1997. Synthesis of (25R)-cholest-5-ene-3β, 26 diol and its radiolabeled analog. Tetrahedron Lett. 38: 3801-3804.
29. Javitt, N. B., E. Kok, J. Lloyd, A. Benscath, and F. H. Field. 1982. Cholest-5-ene-3β, 26-diol: synthesis and biomedical use of a deuterated compound. Biomed. Mass Spectrom. 9: 61-63.
30. Duane, W. C. 1995. Serum lathosterol levels in human subjects reflect changes in whole body cholesterol synthesis induced by lovastatin but not dietary cholesterol. J. Lipid Res. 36: 343-348.
31. Baarends, E. M., A. M. W. J. Schols, W. D. van Marken Lichtenbelt, and E. F. M. Wouters. 1997. Analysis of body water compartments in relation to tissue depletion in clinical stable patients with chronic obstructive pulmonary disease. Am. J. Clin. Nutr. 65: 88-94.
32. 3H]cholic acid as a stable tracer through conversion to deoxycholic acid in human subjects. J. Lipid Res. 37: 431-436.
33. Hahn, C., C. Reichel, and K. von Bergmann. 1995. Serum concentration of 7α-hydroxycholesterol as an indicator of bile acid synthesis in humans. J. Lipid Res. 36: 2059-2066.
34. Sauter, G., F. Berr, U. Beuers, S. Fischer, and G. Paumgartner. 1996. Serum concentrations of 7α-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans. Hepatology. 24: 123-126.
35. Princen, H. M. G., P. Meijer, B. G. Wolthers, R. J. Vonk, and F. Kuipers. 1991. Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. Biochem. J. 275: 501-505.
36. Stocco, D. M. 1998. A review of the characteristics of the protein required for the acute regulation of steroid hormone biosynthesis: the case for the steroidogenic acute regulatory (StAR) protein. Proc. Soc. Exp. Biol. Med. 217: 123-129.
37. Carey, M. C., and W. C. Duane. 1994. Enterohepatic circulation. In The Liver: Biology and Pathobiology. 3 ed. I. M. Arias, J. L. Boyer, N. Fausto, W. B. Jakoby, D. Schachter, and D. A. Shafritz, editors. Raven Press, New York. 719-767.
38. Grundy, S. M. 1984. Cerebrotendinous xanthomatosis. N. Engl. J. Med. 311: 1694-1695.