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Volumn 60, Issue 11, 2015, Pages 3318-3328

Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Author keywords

Bile acid metabolome; Bile acids; Enterohepatic recirculation; Nonalcoholic steatohepatitis

Indexed keywords

ALKALINE PHOSPHATASE; BILE ACID; GLUCOSE; GLYCINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TAURINE; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

EID: 84945465558     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-015-3776-8     Document Type: Article
Times cited : (264)

References (40)
  • 1
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    • PID: 15565570
    • Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40:1387–1395.
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3
  • 2
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • PID: 22656328
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 2012;142:1592–1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 3
    • 65649124573 scopus 로고    scopus 로고
    • Bile-acid-induced cell injury and protection
    • COI: 1:CAS:528:DC%2BD1MXpsFCgs7o%3D, PID: 19360911
    • Perez MJ, Briz O. Bile-acid-induced cell injury and protection. World J Gastroenterol. 2009;15:1677–1689.
    • (2009) World J Gastroenterol , vol.15 , pp. 1677-1689
    • Perez, M.J.1    Briz, O.2
  • 4
    • 84909996208 scopus 로고    scopus 로고
    • Alcoholic and non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC2cXhsFCitrrE, PID: 25217800
    • Neuman MG, French SW, French BA, et al. Alcoholic and non-alcoholic steatohepatitis. Exp Mol Pathol. 2014;97:492–510.
    • (2014) Exp Mol Pathol , vol.97 , pp. 492-510
    • Neuman, M.G.1    French, S.W.2    French, B.A.3
  • 5
    • 79960081870 scopus 로고    scopus 로고
    • Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting
    • COI: 1:CAS:528:DC%2BC3MXps1Cgs7Y%3D, PID: 21760958
    • Trottier J, Bialek A, Caron P, Straka RJ, Milkiewicz P, Barbier O. Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting. PLoS One. 2011;6:e22094.
    • (2011) PLoS One , vol.6 , pp. 22094
    • Trottier, J.1    Bialek, A.2    Caron, P.3    Straka, R.J.4    Milkiewicz, P.5    Barbier, O.6
  • 6
    • 84879604697 scopus 로고    scopus 로고
    • Intestinal microbiota in patients with nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3sXhtVaisr%2FN, PID: 23401313
    • Mouzaki M, Comelli EM, Arendt BM, et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology. 2013;58:120–127.
    • (2013) Hepatology , vol.58 , pp. 120-127
    • Mouzaki, M.1    Comelli, E.M.2    Arendt, B.M.3
  • 7
    • 33244467651 scopus 로고    scopus 로고
    • Bile salt biotransformations by human intestinal bacteria
    • COI: 1:CAS:528:DC%2BD28XhtlaitL8%3D, PID: 16299351
    • Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res. 2006;47:241–259.
    • (2006) J Lipid Res , vol.47 , pp. 241-259
    • Ridlon, J.M.1    Kang, D.J.2    Hylemon, P.B.3
  • 8
    • 0033470181 scopus 로고    scopus 로고
    • Bile acids: the good, the bad, and the ugly
    • COI: 1:CAS:528:DyaK1MXhvVOmt78%3D, PID: 11390813
    • Hofmann AF. Bile acids: the good, the bad, and the ugly. News Physiol Sci. 1999;14:24–29.
    • (1999) News Physiol Sci , vol.14 , pp. 24-29
    • Hofmann, A.F.1
  • 9
    • 84861198882 scopus 로고    scopus 로고
    • FXR and PXR: potential therapeutic targets in cholestasis
    • COI: 1:CAS:528:DC%2BC38XntFahurw%3D, PID: 21801835
    • Jonker JW, Liddle C, Downes M. FXR and PXR: potential therapeutic targets in cholestasis. J Steroid Biochem Mol Biol. 2012;130:147–158.
    • (2012) J Steroid Biochem Mol Biol , vol.130 , pp. 147-158
    • Jonker, J.W.1    Liddle, C.2    Downes, M.3
  • 11
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3sXhtlyrsr3O, PID: 23727264
    • Mudaliar S, Henry RR, Sanyal AJ, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology. 2013;145:574–582.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3
  • 12
    • 84876146580 scopus 로고    scopus 로고
    • Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC3sXlslygtrY%3D, PID: 23299969
    • Bechmann LP, Kocabayoglu P, Sowa JP, et al. Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis. Hepatology. 2013;57:1394–1406.
    • (2013) Hepatology , vol.57 , pp. 1394-1406
    • Bechmann, L.P.1    Kocabayoglu, P.2    Sowa, J.P.3
  • 13
    • 81855206575 scopus 로고    scopus 로고
    • Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3MXhsFCru7%2FN, PID: 21878559
    • Hardwick RN, Fisher CD, Canet MJ, Scheffer GL, Cherrington NJ. Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease. Drug Metab Dispos Biol Fate Chem. 2011;39:2395–2402.
    • (2011) Drug Metab Dispos Biol Fate Chem , vol.39 , pp. 2395-2402
    • Hardwick, R.N.1    Fisher, C.D.2    Canet, M.J.3    Scheffer, G.L.4    Cherrington, N.J.5
  • 14
    • 84929138347 scopus 로고    scopus 로고
    • Altered morphine glucuronide and bile acid disposition in patients with non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC2MXkvFCmtbk%3D, PID: 25669174
    • Ferslew BC, Johnston CK, Tsakalozou E, et al. Altered morphine glucuronide and bile acid disposition in patients with non-alcoholic steatohepatitis. Clin Pharmacol Ther. 2015;97:419–427.
    • (2015) Clin Pharmacol Ther , vol.97 , pp. 419-427
    • Ferslew, B.C.1    Johnston, C.K.2    Tsakalozou, E.3
  • 15
    • 84881478751 scopus 로고    scopus 로고
    • Dysregulated bile acid synthesis, metabolism and excretion in a high fat-cholesterol diet-induced fibrotic steatohepatitis in rats
    • COI: 1:CAS:528:DC%2BC3sXht1Gjs77E, PID: 23824403
    • Jia X, Naito H, Yetti H, et al. Dysregulated bile acid synthesis, metabolism and excretion in a high fat-cholesterol diet-induced fibrotic steatohepatitis in rats. Dig Dis Sci. 2013;58:2212–2222.
    • (2013) Dig Dis Sci , vol.58 , pp. 2212-2222
    • Jia, X.1    Naito, H.2    Yetti, H.3
  • 16
    • 84898824175 scopus 로고    scopus 로고
    • Interactions between the intestinal microbiome and liver diseases
    • COI: 1:CAS:528:DC%2BC2cXmslWqsLc%3D, PID: 24440671
    • Schnabl B, Brenner DA. Interactions between the intestinal microbiome and liver diseases. Gastroenterology. 2014;146:1513–1524.
    • (2014) Gastroenterology , vol.146 , pp. 1513-1524
    • Schnabl, B.1    Brenner, D.A.2
  • 17
    • 84901697873 scopus 로고    scopus 로고
    • Colonic inflammation and secondary bile acids in alcoholic cirrhosis
    • COI: 1:CAS:528:DC%2BC2cXhtFalur7O, PID: 24699327
    • Kakiyama G, Hylemon PB, Zhou H, et al. Colonic inflammation and secondary bile acids in alcoholic cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2014;306:G929–G937.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.306 , pp. 929-937
    • Kakiyama, G.1    Hylemon, P.B.2    Zhou, H.3
  • 18
    • 79951792246 scopus 로고    scopus 로고
    • Plasma metabolomic profile in nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3MXit1Gru7w%3D, PID: 20423748
    • Kalhan SC, Guo L, Edmison J, et al. Plasma metabolomic profile in nonalcoholic fatty liver disease. Metab Clin Exp. 2011;60:404–413.
    • (2011) Metab Clin Exp , vol.60 , pp. 404-413
    • Kalhan, S.C.1    Guo, L.2    Edmison, J.3
  • 19
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • PID: 15915461
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 20
    • 0026559473 scopus 로고
    • Gallbladder emptying stimuli in obese and normal-weight subjects
    • COI: 1:STN:280:DyaK383jsVCmsA%3D%3D, PID: 1568719
    • Stone BG, Ansel HJ, Peterson FJ, Gebhard RL. Gallbladder emptying stimuli in obese and normal-weight subjects. Hepatology. 1992;15:795–798.
    • (1992) Hepatology , vol.15 , pp. 795-798
    • Stone, B.G.1    Ansel, H.J.2    Peterson, F.J.3    Gebhard, R.L.4
  • 21
    • 84922653598 scopus 로고    scopus 로고
    • Profiling of serum bile acids in a healthy Chinese population using UPLC-MS/MS
    • COI: 1:CAS:528:DC%2BC2MXmt1Ortg%3D%3D, PID: 25581415
    • Xie G, Wang Y, Wang X, et al. Profiling of serum bile acids in a healthy Chinese population using UPLC-MS/MS. J Proteome Res. 2015;14:850–859.
    • (2015) J Proteome Res , vol.14 , pp. 850-859
    • Xie, G.1    Wang, Y.2    Wang, X.3
  • 22
    • 84857650587 scopus 로고    scopus 로고
    • Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: a pilot study
    • COI: 1:CAS:528:DC%2BC38Xjs1Gqsbw%3D, PID: 22169272
    • Trottier J, Bialek A, Caron P, et al. Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: a pilot study. Dig Liver Dis. 2012;44:303–310.
    • (2012) Dig Liver Dis , vol.44 , pp. 303-310
    • Trottier, J.1    Bialek, A.2    Caron, P.3
  • 23
    • 84866183656 scopus 로고    scopus 로고
    • Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method
    • COI: 1:CAS:528:DC%2BC38XhtlOmtLbE, PID: 22822028
    • Garcia-Canaveras JC, Donato MT, Castell JV, Lahoz A. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method. J Lipid Res. 2012;53:2231–2241.
    • (2012) J Lipid Res , vol.53 , pp. 2231-2241
    • Garcia-Canaveras, J.C.1    Donato, M.T.2    Castell, J.V.3    Lahoz, A.4
  • 24
    • 84863502669 scopus 로고    scopus 로고
    • Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BC38XpvVegtbc%3D, PID: 22290395
    • Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ. Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology. 2012;56:118–129.
    • (2012) Hepatology , vol.56 , pp. 118-129
    • Tanaka, N.1    Matsubara, T.2    Krausz, K.W.3    Patterson, A.D.4    Gonzalez, F.J.5
  • 25
    • 43449094989 scopus 로고    scopus 로고
    • Bile acid levels are increased in the liver of patients with steatohepatitis
    • COI: 1:CAS:528:DC%2BD1cXlsFOisr0%3D, PID: 18467911
    • Aranha MM, Cortez-Pinto H, Costa A, et al. Bile acid levels are increased in the liver of patients with steatohepatitis. Eur J Gastroenterol Hepatol. 2008;20:519–525.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 519-525
    • Aranha, M.M.1    Cortez-Pinto, H.2    Costa, A.3
  • 26
    • 0037790917 scopus 로고    scopus 로고
    • The enzymes, regulation, and genetics of bile acid synthesis
    • COI: 1:CAS:528:DC%2BD3sXntFSgtLw%3D, PID: 12543708
    • Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72:137–174.
    • (2003) Annu Rev Biochem , vol.72 , pp. 137-174
    • Russell, D.W.1
  • 27
    • 84875066303 scopus 로고    scopus 로고
    • Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BC3sXktlKks7o%3D, PID: 23391614
    • Lake AD, Novak P, Shipkova P, et al. Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease. Toxicol Appl Pharmacol. 2013;268:132–140.
    • (2013) Toxicol Appl Pharmacol , vol.268 , pp. 132-140
    • Lake, A.D.1    Novak, P.2    Shipkova, P.3
  • 28
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • COI: 1:CAS:528:DC%2BD28XivFWitr8%3D, PID: 16473946
    • Inagaki T, Moschetta A, Lee YK, et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci USA. 2006;103:3920–3925.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.K.3
  • 29
    • 69149083245 scopus 로고    scopus 로고
    • TGR5-mediated bile acid sensing controls glucose homeostasis
    • COI: 1:CAS:528:DC%2BD1MXhsVChtLnM, PID: 19723493
    • Thomas C, Gioiello A, Noriega L, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009;10:167–177.
    • (2009) Cell Metab , vol.10 , pp. 167-177
    • Thomas, C.1    Gioiello, A.2    Noriega, L.3
  • 30
    • 31444454037 scopus 로고    scopus 로고
    • Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
    • COI: 1:CAS:528:DC%2BD28XntFWmuw%3D%3D, PID: 16400329
    • Watanabe M, Houten SM, Mataki C, et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006;439:484–489.
    • (2006) Nature , vol.439 , pp. 484-489
    • Watanabe, M.1    Houten, S.M.2    Mataki, C.3
  • 31
    • 0032919402 scopus 로고    scopus 로고
    • Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
    • COI: 1:CAS:528:DyaK1MXjsl2lsQ%3D%3D, PID: 9884343
    • Faubion WA, Guicciardi ME, Miyoshi H, et al. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Investig. 1999;103:137–145.
    • (1999) J Clin Investig , vol.103 , pp. 137-145
    • Faubion, W.A.1    Guicciardi, M.E.2    Miyoshi, H.3
  • 32
    • 0031950282 scopus 로고    scopus 로고
    • Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
    • COI: 1:CAS:528:DyaK1cXis1Wksbw%3D, PID: 9562975
    • Rodrigues CM, Fan G, Wong PY, Kren BT, Steer CJ. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med. 1998;4:165–178.
    • (1998) Mol Med , vol.4 , pp. 165-178
    • Rodrigues, C.M.1    Fan, G.2    Wong, P.Y.3    Kren, B.T.4    Steer, C.J.5
  • 33
    • 0027227827 scopus 로고
    • Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium
    • COI: 1:CAS:528:DyaK3sXlsFOns7Y%3D, PID: 8325981
    • Spivey JR, Bronk SF, Gores GJ. Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium. J Clin Investig. 1993;92:17–24.
    • (1993) J Clin Investig , vol.92 , pp. 17-24
    • Spivey, J.R.1    Bronk, S.F.2    Gores, G.J.3
  • 34
    • 0032525819 scopus 로고    scopus 로고
    • A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
    • COI: 1:CAS:528:DyaK1cXktVSiu74%3D, PID: 9637713
    • Rodrigues CM, Fan G, Ma X, Kren BT, Steer CJ. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. J Clin Investig. 1998;101:2790–2799.
    • (1998) J Clin Investig , vol.101 , pp. 2790-2799
    • Rodrigues, C.M.1    Fan, G.2    Ma, X.3    Kren, B.T.4    Steer, C.J.5
  • 35
    • 11844262660 scopus 로고    scopus 로고
    • Bile acids as carcinogens in human gastrointestinal cancers
    • COI: 1:CAS:528:DC%2BD2MXis1Wluw%3D%3D, PID: 15652226
    • Bernstein H, Bernstein C, Payne CM, Dvorakova K, Garewal H. Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res. 2005;589:47–65.
    • (2005) Mutat Res , vol.589 , pp. 47-65
    • Bernstein, H.1    Bernstein, C.2    Payne, C.M.3    Dvorakova, K.4    Garewal, H.5
  • 36
    • 84861197159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
    • PID: 22326465
    • Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol. 2012;56:1384–1391.
    • (2012) J Hepatol , vol.56 , pp. 1384-1391
    • Baffy, G.1    Brunt, E.M.2    Caldwell, S.H.3
  • 37
    • 34948867745 scopus 로고    scopus 로고
    • Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
    • COI: 1:STN:280:DC%2BD2srovFSjsg%3D%3D, PID: 17700568
    • Larsson SC, Wolk A. Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies. Br J Cancer. 2007;97:1005–1008.
    • (2007) Br J Cancer , vol.97 , pp. 1005-1008
    • Larsson, S.C.1    Wolk, A.2
  • 38
    • 34247578216 scopus 로고    scopus 로고
    • Obesity and the risk of gallbladder cancer: a meta-analysis
    • COI: 1:STN:280:DC%2BD2s3mt1Ghsw%3D%3D, PID: 17375043
    • Larsson SC, Wolk A. Obesity and the risk of gallbladder cancer: a meta-analysis. Br J Cancer. 2007;96:1457–1461.
    • (2007) Br J Cancer , vol.96 , pp. 1457-1461
    • Larsson, S.C.1    Wolk, A.2
  • 39
    • 0017234466 scopus 로고
    • Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats
    • COI: 1:STN:280:DyaE287ks1Kqug%3D%3D, PID: 1255778
    • Reddy BS, Narasawa T, Weisburger JH, Wynder EL. Promoting effect of sodium deoxycholate on colon adenocarcinomas in germfree rats. J Natl Cancer Inst. 1976;56:441–442.
    • (1976) J Natl Cancer Inst , vol.56 , pp. 441-442
    • Reddy, B.S.1    Narasawa, T.2    Weisburger, J.H.3    Wynder, E.L.4
  • 40
    • 79958243702 scopus 로고
    • Role of nuclear receptor SHP in metabolism and cancer
    • Zhang Y, Hagedorn CH, Wang L. Role of nuclear receptor SHP in metabolism and cancer. Biochim Biophys Acta. 1812;2011:893–908.
    • (1812) Biochim Biophys Acta , vol.2011 , pp. 893-908
    • Zhang, Y.1    Hagedorn, C.H.2    Wang, L.3


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