Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults

Nutrition and Metabolism

Volumn 8, Issue , 2011, Pages

  Cariou, Bertrand ^a   Chetiveaux, Maud ^a   Zar, Yassine ^a   Pouteau, Etienne ^b   Disse, Emmanuel ^c   Guyomarc'H Delasalle, Béatrice ^a   Laville, Martine ^c   Krempf, Michel ^a  

^a UNIVERSITÉ DE NANTES   (France)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

bile acids; energy expenditure; FXR; hyperinsulinemic euglycemic clamp; insulin resistance; TGR5; type 2 diabetes

Indexed keywords

CHENODEOXYCHOLIC ACID; CHOLIC ACID; DEOXYCHOLIC ACID; HEMOGLOBIN A1C; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BILE ACID BLOOD LEVEL; BODY MASS; CALORIMETRY; CHOLESTEROL BLOOD LEVEL; CHROMATOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENERGY EXPENDITURE; FEMALE; GLUCOSE INFUSION; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; TRIACYLGLYCEROL BLOOD LEVEL;

MUS;

EID: 79959975693     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-8-48     Document Type: Article

References (22)

1. Role of bile acids and bile acid receptors in metabolic regulation. P Lefebvre B Cariou F Lien F Kuipers B Staels, Physiol Rev 2009 89 147 91 10.1152/physrev.00010.2008 19126757
2. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. CJ Sinal M Tohkin M Miyata JM Ward G Lambert FJ Gonzalez, Cell 2000 102 731 44 10.1016/S0092-8674(00)00062-3 11030617
3. Enterohepatic circulation of bile salts in farnesoid × receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. T Kok CV Hulzebos H Wolters R Havinga LB Agellon F Steellaard B Shan M Schwarz F Kuipers, J Biol Chem 2003 278 41930 7 10.1074/jbc.M306309200 12917447 (Pubitemid 37310455)
4. FXR: a promising target for the metabolic syndrome? B Cariou B Staels, Trends Pharmacol Sci 2007 5 236 43 (Pubitemid 46661001)
5. Potential regulatory role of the farnesoid × receptor in the metabolic syndrome. D Duran-Sandoval B Cariou JC Fruchart B Staels, Biochimie 2005 87 93 8 10.1016/j.biochi.2004.11.018 15733743 (Pubitemid 40298771)
6. The farnesoid × receptor modulates adiposity and peripheral insulin sensitivity in mice. B Cariou K van Harmelen D Duran-Sandoval TH van Dijk A Grefhorst M Abdelkarim S Caron G Torpier JC Fruchart FJ Gonzalez F Kuipers B Staels, J Biol Chem 2006 281 11039 49 10.1074/jbc.M510258200 16446356 (Pubitemid 43855527)
7. Farnesoid × receptor is essential for normal glucose homeostasis. K Ma PK Saha L Chan DD Moore, J Clin Invest 2006 116 1102 9 10.1172/JCI25604 16557297
8. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Y Zhang FY Lee G Barrera H Lee C Vales FJ Gonzalez TM Willson PA Edwards, Proc Natl Acad Sci USA 2006 103 1006 11 10.1073/pnas.0506982103 16410358 (Pubitemid 43212212)
9. Farnesoid × receptor deficiency improves glucose homeostasis in mouse models of obesity. J Prawitt M Abdelkarim JH Stroeve I Popescu H Duez VR Velagapudi J Dumont E Bouchaert TH van Dijk A Lucas E Dorchies M Daoudi S Lestavel FJ Gonzalez M Oresic B Cariou F Kuipers S Caron B Staels, Diabetes 2011 60 1861 71 10.2337/db11-0030 21593203
10. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. M Watanabe SM Houten C Mataki MA Christoffolete BW Kim H Sato N Messaddeq JW Harney O Ezaki T Kodama K Schoonjans AC Bianco J Auwerx, Nature 2006 439 484 9 10.1038/nature04330 16400329 (Pubitemid 43152840)
11. Identification of membrae-type receptor for bile acids (M-BAR). T Maruyama Y Miyamoto T Nakamura Y Tamai H Okada E Sugiyama T Nakamura H Itadani K Tanaka, Biochem Biophys Res Commun 2002 298 714 719 10.1016/S0006-291X(02) 02550-0 12419312 (Pubitemid 35356798)
12. A G protein-coupled receptor responsive to bile acids. Y Kawamata R Fujii M Hosoya M Harada H Yoshida M Miwa S Fukusumi Y Habata T Itoh Y Shintani S Hinuma Y Fujisawa M Fujino, J Biol Chem 2003 278 9435 40 10.1074/jbc.M209706200 12524422 (Pubitemid 36800434)
13. TGR5-mediated bile acid sensing controls glucose homeostasis. C Thomas A Gioiello L Noriega A Strehle J Oury G Rizzo A Macchiarulo H Yamamoto C Mataki M Pruzanski R Pellicciari J Auwerx K Schoonjans, Cell Metab 2009 10 167 77 10.1016/j.cmet.2009.08.001 19723493
14. Determination of plasma bile acids by capillary gas-liquid chromatography-electron capture negative chemical ionization mass fragmentography. F Stellaard SA Langelaar RM Kok C Jakobs, J Lipid Res 1998 30 1647 52
15. Glucose clamp technique: a method for quantifying insulin secretion and resistance. RA DeFronzo JD Tobin R Andres, Am J Physiol 1979 237 214 E223 382871
16. A new therapy for nonalcoholic fatty liver disease and diabetes? INT-747-the first FXR hepatic therapeutic study. AJ Sanyal S Mudaliar RR Henry HU Marschall L Morrow CI Sciacca P Dillon P Clopton M Kipnes D Shapiro, Hepatology 2009 50 Suppl S 389 390A
17. Effects of diabetes mellitus on cholesterol metabolism in man. LJ Bennion SM Grundy, N Engl J Med 1997 296 1365 71
18. Metabolism of cholesterol and plasma triglycerides in nonketotic diabetes mellitus. JJ Abrams H Ginsberg SM Grundy, Diabetes 1982 31 903 10 10.2337/diabetes.31.10.903 6759223 (Pubitemid 12013795)
19. Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. G Brufau F Stellaard K Prado VW Bloks E Jonkers R Boverhof F Kuipers E Murphy, Hepatology 2010 52 1455 10.1002/hep.23831 20725912
20. Bile acid sequestrants and the treatment of type 2 diabetes mellitus. B Staels F Kuipers, Drugs 2007 67 1383 92 10.2165/00003495-200767100-00001 17600387 (Pubitemid 47026388)
21. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. O Shaham R Wei TJ Wang C Ricciardi GD Lewis RS Vasan SA Carr R Thadhani RE Gerszten VK Mootha, Mol Syst Biol 2008 4 214 18682704
22. Plasma bile acids are not associated with energy metabolism in humans. G Brufau MJ Bahr B Staels T Claudel J Ockenga KH Böker EJ Murphy K Prado F Stellaard MP Manns F Kuipers UJ Tietge, Nutr Metab (Lond) 2010 7 73 10.1186/1743-7075-7-73