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Volumn 6, Issue 11, 2017, Pages

Trial watch: Immune checkpoint blockers for cancer therapy

(13)  Vanpouille Box, Claire a   Lhuillier, Claire a   Bezu, Lucillia b,c,d,e,f   Aranda, Fernando g   Yamazaki, Takahiro a   Kepp, Oliver b,c,d,e,f   Fucikova, Jitka h,i   Spisek, Radek h,i   Demaria, Sandra a   Formenti, Silvia C a   Zitvogel, Laurence f,j,k,l   Kroemer, Guido b,c,d,e,f,m,n   Galluzzi, Lorenzo a,b  

e INSERM   (France)

Author keywords

Atezolizumab; avelumab; durvalumab; ipilimumab; nivolumab; pembrolizumab

Indexed keywords

ATEZOLIZUMAB; AVELUMAB; BIOLOGICAL MARKER; BRCA1 PROTEIN; DURVALUMAB; IPILIMUMAB; NIVOLUMAB; PADGEM PROTEIN; PEMBROLIZUMAB; PROGRAMMED DEATH 1 RECEPTOR;

EID: 85033391496     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2017.1373237     Document Type: Review
Times cited : (62)

References (314)
  • 1
    • 77957361348 scopus 로고    scopus 로고
    • Development trends for human monoclonal antibody therapeutics
    • 20811384,. https://doi.org/,. PMID
    • Nelson AL, Dhimolea E, Reichert JM. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov. 2010;9:767-74. https://doi.org/10.1038/nrd3229. PMID:20811384
    • (2010) Nat Rev Drug Discov. , vol.9 , pp. 767-774
    • Nelson, A.L.1    Dhimolea, E.2    Reichert, J.M.3
  • 4
    • 85016437322 scopus 로고    scopus 로고
    • Doubling the blockade for melanoma immunotherapy
    • 26942094,. https://doi.org/,. PMID
    • Galluzzi L, Eggermont A, Kroemer G. Doubling the blockade for melanoma immunotherapy. Oncoimmunology. 2016; 5:e1106127. https://doi.org/10.1080/2162402X.2015.1106127. PMID:26942094
    • (2016) Oncoimmunology. , vol.5 , pp. e1106127
    • Galluzzi, L.1    Eggermont, A.2    Kroemer, G.3
  • 5
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • 22193102,. https://doi.org/,. PMID
    • Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011; 480:480-9. https://doi.org/10.1038/nature10673. PMID:22193102
    • (2011) Nature. , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 6
    • 81055127514 scopus 로고    scopus 로고
    • Anti-CTLA4 monoclonal antibodies: The past and the future in clinical application
    • 22077981,. https://doi.org/,. PMID
    • Ascierto PA, Marincola FM, Ribas A. Anti-CTLA4 monoclonal antibodies: The past and the future in clinical application. J Transl Med. 2011; 9:196. https://doi.org/10.1186/1479-5876-9-196. PMID:22077981
    • (2011) J Transl Med. , vol.9 , pp. 196
    • Ascierto, P.A.1    Marincola, F.M.2    Ribas, A.3
  • 7
    • 84876678621 scopus 로고    scopus 로고
    • Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: Detailed safety analysis from a phase 3 trial in patients with advanced melanoma
    • 23400564,. https://doi.org/,. PMID
    • Weber JS, Dummer R, de Pril V, Lebbe C, Hodi FS, Investigators MDX. Patterns of onset and resolution of immune-related adverse events of special interest with ipilimumab: Detailed safety analysis from a phase 3 trial in patients with advanced melanoma. Cancer. 2013; 119:1675-82. https://doi.org/10.1002/cncr.27969. PMID:23400564
    • (2013) Cancer. , vol.119 , pp. 1675-1682
    • Weber, J.S.1    Dummer, R.2    de Pril, V.3    Lebbe, C.4    Hodi, F.S.5
  • 8
    • 84877093633 scopus 로고    scopus 로고
    • Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control
    • 23444228,. https://doi.org/,. PMID
    • Robert C, Schadendorf D, Messina M, Hodi FS, O'Day S, Investigators MDX. Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control. Clin Cancer Res. 2013; 19:2232-9. https://doi.org/10.1158/1078-0432.CCR-12-3080. PMID:23444228
    • (2013) Clin Cancer Res. , vol.19 , pp. 2232-2239
    • Robert, C.1    Schadendorf, D.2    Messina, M.3    Hodi, F.S.4    O'Day, S.5
  • 9
    • 84884721380 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20)
    • 23942774,. https://doi.org/,. PMID
    • McDermott D, Haanen J, Chen TT, Lorigan P, O'Day S, Investigators MDX. Efficacy and safety of ipilimumab in metastatic melanoma patients surviving more than 2 years following treatment in a phase III trial (MDX010-20). Ann Oncol. 2013; 24:2694-8. https://doi.org/10.1093/annonc/mdt291. PMID:23942774
    • (2013) Ann Oncol. , vol.24 , pp. 2694-2698
    • McDermott, D.1    Haanen, J.2    Chen, T.T.3    Lorigan, P.4    O'Day, S.5
  • 10
    • 84927130807 scopus 로고    scopus 로고
    • Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential
    • 25860605,. https://doi.org/,. PMID
    • Sharma P, Allison JP. Immune checkpoint targeting in cancer therapy: Toward combination strategies with curative potential. Cell. 2015; 161:205-14. https://doi.org/10.1016/j.cell.2015.03.030. PMID:25860605
    • (2015) Cell. , vol.161 , pp. 205-214
    • Sharma, P.1    Allison, J.P.2
  • 11
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • 25838373,. https://doi.org/,. PMID
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015; 348:56-61. https://doi.org/10.1126/science.aaa8172. PMID:25838373
    • (2015) Science. , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 12
    • 80054875641 scopus 로고    scopus 로고
    • Novel cancer immunotherapy agents with survival benefit: Recent successes and next steps
    • 22020206,. https://doi.org/,. PMID
    • Sharma P, Wagner K, Wolchok JD, Allison JP. Novel cancer immunotherapy agents with survival benefit: Recent successes and next steps. Nat Rev Cancer. 2011; 11:805-12. https://doi.org/10.1038/nrc3153. PMID:22020206
    • (2011) Nat Rev Cancer. , vol.11 , pp. 805-812
    • Sharma, P.1    Wagner, K.2    Wolchok, J.D.3    Allison, J.P.4
  • 13
    • 84960422665 scopus 로고    scopus 로고
    • The basis of oncoimmunology
    • 26967289,. https://doi.org/,. PMID
    • Palucka AK, Coussens LM. The basis of oncoimmunology. Cell. 2016; 164:1233-47. https://doi.org/10.1016/j.cell.2016.01.049. PMID:26967289
    • (2016) Cell. , vol.164 , pp. 1233-1247
    • Palucka, A.K.1    Coussens, L.M.2
  • 14
    • 84928062583 scopus 로고    scopus 로고
    • Immune checkpoint blockade: A common denominator approach to cancer therapy
    • 25858804,. https://doi.org/,. PMID
    • Topalian SL, Drake CG, Pardoll DM. Immune checkpoint blockade: A common denominator approach to cancer therapy. Cancer Cell. 2015; 27:450-61. https://doi.org/10.1016/j.ccell.2015.03.001. PMID:25858804
    • (2015) Cancer Cell. , vol.27 , pp. 450-461
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 15
    • 84961588772 scopus 로고    scopus 로고
    • Prime time for immune-checkpoint targeted therapy at ASCO 2015
    • 27141332,. https://doi.org/,. PMID
    • Marabelle A, Routy B, Michels J, Kroemer G, Zitvogel L. Prime time for immune-checkpoint targeted therapy at ASCO 2015. Oncoimmunology. 2016; 5:e1068494. https://doi.org/10.1080/2162402X.2015.1068494. PMID:27141332
    • (2016) Oncoimmunology. , vol.5 , pp. e1068494
    • Marabelle, A.1    Routy, B.2    Michels, J.3    Kroemer, G.4    Zitvogel, L.5
  • 16
  • 17
    • 84921448324 scopus 로고    scopus 로고
    • The evolution of checkpoint blockade as a cancer therapy: What's here, what's next?
    • 25621841,. https://doi.org/,. PMID
    • Shin DS, Ribas A. The evolution of checkpoint blockade as a cancer therapy: What's here, what's next? Curr Opin Immunol. 2015; 33:23-35. https://doi.org/10.1016/j.coi.2015.01.006. PMID:25621841
    • (2015) Curr Opin Immunol. , vol.33 , pp. 23-35
    • Shin, D.S.1    Ribas, A.2
  • 18
    • 85018759710 scopus 로고    scopus 로고
    • Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis
    • 28469254, et al.,. https://doi.org/,. PMID
    • Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, et al. Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis. Sci Rep. 2017; 7:1485. https://doi.org/10.1038/s41598-017-01411-1. PMID:28469254
    • (2017) Sci Rep. , vol.7 , pp. 1485
    • Li, N.1    Xu, W.2    Yuan, Y.3    Ayithan, N.4    Imai, Y.5    Wu, X.6    Miller, H.7    Olson, M.8    Feng, Y.9    Huang, Y.H.10
  • 19
    • 85016090030 scopus 로고    scopus 로고
    • VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
    • 28346412, et al.,. https://doi.org/,. PMID
    • Gao J, Ward JF, Pettaway CA, Shi LZ, Subudhi SK, Vence LM, Zhao H, Chen J, Chen H, Efstathiou E, et al. VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer. Nat Med. 2017; 23:551-5. https://doi.org/10.1038/nm.4308. PMID:28346412
    • (2017) Nat Med. , vol.23 , pp. 551-555
    • Gao, J.1    Ward, J.F.2    Pettaway, C.A.3    Shi, L.Z.4    Subudhi, S.K.5    Vence, L.M.6    Zhao, H.7    Chen, J.8    Chen, H.9    Efstathiou, E.10
  • 22
    • 84938799943 scopus 로고    scopus 로고
    • Reversal of natural killer cell exhaustion by TIM-3 blockade
    • 25964857,. https://doi.org/,. PMID
    • Gallois A, Silva I, Osman I, Bhardwaj N. Reversal of natural killer cell exhaustion by TIM-3 blockade. Oncoimmunology. 2014; 3:e946365. https://doi.org/10.4161/21624011.2014.946365. PMID:25964857
    • (2014) Oncoimmunology. , vol.3 , pp. e946365
    • Gallois, A.1    Silva, I.2    Osman, I.3    Bhardwaj, N.4
  • 23
    • 84991032331 scopus 로고    scopus 로고
    • Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk
    • 27853635,. https://doi.org/,. PMID
    • Li J, Shayan G, Avery L, Jie HB, Gildener-Leapman N, Schmitt N, Lu BF, Kane LP, Ferris RL. Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk. Oncoimmunology. 2016; 5:e1200778. https://doi.org/10.1080/2162402X.2016.1200778. PMID:27853635
    • (2016) Oncoimmunology. , vol.5 , pp. e1200778
    • Li, J.1    Shayan, G.2    Avery, L.3    Jie, H.B.4    Gildener-Leapman, N.5    Schmitt, N.6    Lu, B.F.7    Kane, L.P.8    Ferris, R.L.9
  • 24
    • 80155127321 scopus 로고    scopus 로고
    • Prospects for TIM3-targeted antitumor immunotherapy
    • 22009533,. https://doi.org/,. PMID
    • Ngiow SF, Teng MW, Smyth MJ. Prospects for TIM3-targeted antitumor immunotherapy. Cancer Res. 2011; 71:6567-71. https://doi.org/10.1158/0008-5472.CAN-11-1487. PMID:22009533
    • (2011) Cancer Res. , vol.71 , pp. 6567-6571
    • Ngiow, S.F.1    Teng, M.W.2    Smyth, M.J.3
  • 25
    • 84859157752 scopus 로고    scopus 로고
    • Tim-3, a negative regulator of anti-tumor immunity
    • 22226204,. https://doi.org/,. PMID
    • Anderson AC. Tim-3, a negative regulator of anti-tumor immunity. Curr Opin Immunol. 2012; 24:213-6. https://doi.org/10.1016/j.coi.2011.12.005. PMID:22226204
    • (2012) Curr Opin Immunol. , vol.24 , pp. 213-216
    • Anderson, A.C.1
  • 26
    • 84994876972 scopus 로고    scopus 로고
    • LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma
    • 27999760,. https://doi.org/,. PMID
    • Deng WW, Mao L, Yu GT, Bu LL, Ma SR, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ. LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma. Oncoimmunology. 2016; 5:e1239005. https://doi.org/10.1080/2162402X.2016.1239005. PMID:27999760
    • (2016) Oncoimmunology. , vol.5 , pp. e1239005
    • Deng, W.W.1    Mao, L.2    Yu, G.T.3    Bu, L.L.4    Ma, S.R.5    Liu, B.6    Gutkind, J.S.7    Kulkarni, A.B.8    Zhang, W.F.9    Sun, Z.J.10
  • 28
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • 22186141, et al.,. https://doi.org/,. PMID
    • Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, Bettini ML, Gravano DM, Vogel P, Liu CL, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 2012; 72:917-27. https://doi.org/10.1158/0008-5472.CAN-11-1620. PMID:22186141
    • (2012) Cancer Res. , vol.72 , pp. 917-927
    • Woo, S.R.1    Turnis, M.E.2    Goldberg, M.V.3    Bankoti, J.4    Selby, M.5    Nirschl, C.J.6    Bettini, M.L.7    Gravano, D.M.8    Vogel, P.9    Liu, C.L.10
  • 29
    • 85021440118 scopus 로고    scopus 로고
    • The future of immune checkpoint cancer therapy after PD-1 and CTLA-4
    • 28653573,. https://doi.org/,. PMID
    • Hahn AW, Gill DM, Pal SK, Agarwal N. The future of immune checkpoint cancer therapy after PD-1 and CTLA-4. Immunotherapy. 2017; 9:681-92. https://doi.org/10.2217/imt-2017-0024. PMID:28653573
    • (2017) Immunotherapy. , vol.9 , pp. 681-692
    • Hahn, A.W.1    Gill, D.M.2    Pal, S.K.3    Agarwal, N.4
  • 30
    • 85029549369 scopus 로고    scopus 로고
    • Control of metastasis by NK cells
    • 28810142,. doi:,. PMID
    • Lopez-Soto A, Gonzalez S, Smyth MJ, Galluzzi L. Control of metastasis by NK cells. Cancer Cell. 2017;32:135-54. doi:10.1016/j.ccell.2017.06.009. PMID:28810142
    • (2017) Cancer Cell. , vol.32 , pp. 135-154
    • Lopez-Soto, A.1    Gonzalez, S.2    Smyth, M.J.3    Galluzzi, L.4
  • 31
    • 85023180528 scopus 로고    scopus 로고
    • Natural killer cell-based cancer immunotherapies: From immune evasion to promising targeted cellular therapies
    • 28747910,. https://doi.org/,. PMID
    • Hofer E, Koehl U. Natural killer cell-based cancer immunotherapies: From immune evasion to promising targeted cellular therapies. Front Immunol. 2017; 8:745. https://doi.org/10.3389/fimmu.2017.00745. PMID:28747910
    • (2017) Front Immunol. , vol.8 , pp. 745
    • Hofer, E.1    Koehl, U.2
  • 32
    • 85014339020 scopus 로고    scopus 로고
    • TIGIT and CD96: New checkpoint receptor targets for cancer immunotherapy
    • 28258695,. https://doi.org/,. PMID
    • Dougall WC, Kurtulus S, Smyth MJ, Anderson AC. TIGIT and CD96: New checkpoint receptor targets for cancer immunotherapy. Immunol Rev. 2017; 276:112-20. https://doi.org/10.1111/imr.12518. PMID:28258695
    • (2017) Immunol Rev. , vol.276 , pp. 112-120
    • Dougall, W.C.1    Kurtulus, S.2    Smyth, M.J.3    Anderson, A.C.4
  • 37
    • 85032474511 scopus 로고    scopus 로고
    • First tissue-agnostic drug approval issued
    • First tissue-agnostic drug approval issued. Cancer Discov. 2017; 7:656.
    • (2017) Cancer Discov. , vol.7 , pp. 656
  • 38
    • 85018755268 scopus 로고    scopus 로고
    • DNA damage in stem cells
    • 28475867,. https://doi.org/,. PMID
    • Vitale I, Manic G, De Maria R, Kroemer G, Galluzzi L. DNA damage in stem cells. Mol Cell. 2017; 66:306-19. https://doi.org/10.1016/j.molcel.2017.04.006. PMID:28475867
    • (2017) Mol Cell. , vol.66 , pp. 306-319
    • Vitale, I.1    Manic, G.2    De Maria, R.3    Kroemer, G.4    Galluzzi, L.5
  • 39
    • 84951858024 scopus 로고    scopus 로고
    • Mutational profiling of colorectal cancers with microsatellite instability
    • 26517354,. https://doi.org/,. PMID
    • Lin EI, Tseng LH, Gocke CD, Reil S, Le DT, Azad NS, Eshleman JR. Mutational profiling of colorectal cancers with microsatellite instability. Oncotarget. 2015; 6:42334-44. https://doi.org/10.18632/oncotarget.5997. PMID:26517354
    • (2015) Oncotarget. , vol.6 , pp. 42334-42344
    • Lin, E.I.1    Tseng, L.H.2    Gocke, C.D.3    Reil, S.4    Le, D.T.5    Azad, N.S.6    Eshleman, J.R.7
  • 40
    • 85020910893 scopus 로고    scopus 로고
    • In a major shift, cancer drugs go ‘tissue-agnostic’
    • 28619894,. https://doi.org/,. PMID
    • Garber K. In a major shift, cancer drugs go ‘tissue-agnostic’. Science. 2017; 356:1111-2. https://doi.org/10.1126/science.356.6343.1111. PMID:28619894
    • (2017) Science. , vol.356 , pp. 1111-1112
    • Garber, K.1
  • 41
    • 85033395555 scopus 로고    scopus 로고
    • Tissue-agnostic drug development
    • 28561648,. https://doi.org/,. PMID
    • Flaherty KT, Le DT, Lemery S. Tissue-agnostic drug development. Am Soc Clin Oncol Educ Book. 2017; 37:222-30. https://doi.org/10.14694/EDBK_173855. PMID:28561648
    • (2017) Am Soc Clin Oncol Educ Book. , vol.37 , pp. 222-230
    • Flaherty, K.T.1    Le, D.T.2    Lemery, S.3
  • 42
    • 85014681380 scopus 로고    scopus 로고
    • Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance
    • 28251903, et al.,. https://doi.org/,. PMID
    • Roh W, Chen PL, Reuben A, Spencer CN, Prieto PA, Miller JP, Gopalakrishnan V, Wang F, Cooper ZA, Reddy SM, et al. Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Sci Transl Med. 2017; 9:eaah3560. https://doi.org/10.1126/scitranslmed.aah3560. PMID:28251903
    • (2017) Sci Transl Med. , vol.9 , pp. eaah3560
    • Roh, W.1    Chen, P.L.2    Reuben, A.3    Spencer, C.N.4    Prieto, P.A.5    Miller, J.P.6    Gopalakrishnan, V.7    Wang, F.8    Cooper, Z.A.9    Reddy, S.M.10
  • 43
    • 85014004127 scopus 로고    scopus 로고
    • Suppression of Type I IFN signaling in tumors mediates resistance to Anti-PD-1 treatment that can be overcome by radiotherapy
    • 27821490, et al.,. https://doi.org/,. PMID
    • Wang X, Schoenhals JE, Li A, Valdecanas DR, Ye H, Zang F, Tang C, Tang M, Liu CG, Liu X, et al. Suppression of Type I IFN signaling in tumors mediates resistance to Anti-PD-1 treatment that can be overcome by radiotherapy. Cancer Res. 2017; 77:839-50. https://doi.org/10.1158/0008-5472.CAN-15-3142. PMID:27821490
    • (2017) Cancer Res. , vol.77 , pp. 839-850
    • Wang, X.1    Schoenhals, J.E.2    Li, A.3    Valdecanas, D.R.4    Ye, H.5    Zang, F.6    Tang, C.7    Tang, M.8    Liu, C.G.9    Liu, X.10
  • 44
    • 84990849572 scopus 로고    scopus 로고
    • Loss of IFN-gamma pathway genes in tumor cells as a mechanism of resistance to Anti-CTLA-4 therapy
    • 27667683, et al.,. https://doi.org/,. PMID
    • Gao J, Shi LZ, Zhao H, Chen J, Xiong L, He Q, Chen T, Roszik J, Bernatchez C, Woodman SE, et al. Loss of IFN-gamma pathway genes in tumor cells as a mechanism of resistance to Anti-CTLA-4 therapy. Cell. 2016; 167:397-404 e9. https://doi.org/10.1016/j.cell.2016.08.069. PMID:27667683
    • (2016) Cell. , vol.167 , pp. 397-404 e9
    • Gao, J.1    Shi, L.Z.2    Zhao, H.3    Chen, J.4    Xiong, L.5    He, Q.6    Chen, T.7    Roszik, J.8    Bernatchez, C.9    Woodman, S.E.10
  • 46
    • 85012158583 scopus 로고    scopus 로고
    • Primary, adaptive, and acquired resistance to cancer immunotherapy
    • 28187290,. https://doi.org/,. PMID
    • Sharma P, Hu-Lieskovan S, Wargo JA, Ribas A. Primary, adaptive, and acquired resistance to cancer immunotherapy. Cell. 2017; 168:707-23. https://doi.org/10.1016/j.cell.2017.01.017. PMID:28187290
    • (2017) Cell. , vol.168 , pp. 707-723
    • Sharma, P.1    Hu-Lieskovan, S.2    Wargo, J.A.3    Ribas, A.4
  • 47
    • 84961221351 scopus 로고    scopus 로고
    • Genomic and transcriptomic features of response to Anti-PD-1 therapy in metastatic melanoma
    • 26997480, et al.,. https://doi.org/,. PMID
    • Hugo W, Zaretsky JM, Sun L, Song C, Moreno BH, Hu-Lieskovan S, Berent-Maoz B, Pang J, Chmielowski B, Cherry G, et al. Genomic and transcriptomic features of response to Anti-PD-1 therapy in metastatic melanoma. Cell. 2016; 165:35-44. https://doi.org/10.1016/j.cell.2016.02.065. PMID:26997480
    • (2016) Cell. , vol.165 , pp. 35-44
    • Hugo, W.1    Zaretsky, J.M.2    Sun, L.3    Song, C.4    Moreno, B.H.5    Hu-Lieskovan, S.6    Berent-Maoz, B.7    Pang, J.8    Chmielowski, B.9    Cherry, G.10
  • 48
    • 84995948061 scopus 로고    scopus 로고
    • Overcoming resistance to checkpoint blockade therapy by targeting PI3Kgamma in myeloid cells
    • 27828943, et al.,. https://doi.org/,. PMID
    • De Henau O, Rausch M, Winkler D, Campesato LF, Liu C, Cymerman DH, Budhu S, Ghosh A, Pink M, Tchaicha J, et al. Overcoming resistance to checkpoint blockade therapy by targeting PI3Kgamma in myeloid cells. Nature. 2016; 539:443-7. https://doi.org/10.1038/nature20554. PMID:27828943
    • (2016) Nature. , vol.539 , pp. 443-447
    • De Henau, O.1    Rausch, M.2    Winkler, D.3    Campesato, L.F.4    Liu, C.5    Cymerman, D.H.6    Budhu, S.7    Ghosh, A.8    Pink, M.9    Tchaicha, J.10
  • 49
    • 85013925425 scopus 로고    scopus 로고
    • Loss of PTEN is associated with resistance to Anti-PD-1 checkpoint blockade therapy in metastatic uterine leiomyosarcoma
    • 28228279, et al.,. https://doi.org/,. PMID
    • George S, Miao D, Demetri GD, Adeegbe D, Rodig SJ, Shukla S, Lipschitz M, Amin-Mansour A, Raut CP, Carter SL, et al. Loss of PTEN is associated with resistance to Anti-PD-1 checkpoint blockade therapy in metastatic uterine leiomyosarcoma. Immunity. 2017; 46:197-204. https://doi.org/10.1016/j.immuni.2017.02.001. PMID:28228279
    • (2017) Immunity. , vol.46 , pp. 197-204
    • George, S.1    Miao, D.2    Demetri, G.D.3    Adeegbe, D.4    Rodig, S.J.5    Shukla, S.6    Lipschitz, M.7    Amin-Mansour, A.8    Raut, C.P.9    Carter, S.L.10
  • 50
    • 84975059616 scopus 로고    scopus 로고
    • Resistance mechanisms to immune-checkpoint blockade in cancer: Tumor-intrinsic and -extrinsic factors
    • 27332730, et al.,. https://doi.org/,. PMID
    • Pitt JM, Vetizou M, Daillere R, Roberti MP, Yamazaki T, Routy B, Lepage P, Boneca IG, Chamaillard M, Kroemer G, et al. Resistance mechanisms to immune-checkpoint blockade in cancer: Tumor-intrinsic and -extrinsic factors. Immunity. 2016; 44:1255-69. https://doi.org/10.1016/j.immuni.2016.06.001. PMID:27332730
    • (2016) Immunity. , vol.44 , pp. 1255-1269
    • Pitt, J.M.1    Vetizou, M.2    Daillere, R.3    Roberti, M.P.4    Yamazaki, T.5    Routy, B.6    Lepage, P.7    Boneca, I.G.8    Chamaillard, M.9    Kroemer, G.10
  • 51
    • 84982946696 scopus 로고    scopus 로고
    • Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade
    • 27301722, et al.,. https://doi.org/,. PMID
    • Chen PL, Roh W, Reuben A, Cooper ZA, Spencer CN, Prieto PA, Miller JP, Bassett RL, Gopalakrishnan V, Wani K, et al. Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade. Cancer Discov. 2016; 6:827-37. https://doi.org/10.1158/2159-8290.CD-15-1545. PMID:27301722
    • (2016) Cancer Discov. , vol.6 , pp. 827-837
    • Chen, P.L.1    Roh, W.2    Reuben, A.3    Cooper, Z.A.4    Spencer, C.N.5    Prieto, P.A.6    Miller, J.P.7    Bassett, R.L.8    Gopalakrishnan, V.9    Wani, K.10
  • 52
    • 85009968823 scopus 로고    scopus 로고
    • Cancer immunotherapy–immune checkpoint blockade and associated endocrinopathies
    • 28106152,. https://doi.org/,. PMID
    • Byun DJ, Wolchok JD, Rosenberg LM, Girotra M. Cancer immunotherapy–immune checkpoint blockade and associated endocrinopathies. Nat Rev Endocrinol. 2017; 13:195-207. https://doi.org/10.1038/nrendo.2016.205. PMID:28106152
    • (2017) Nat Rev Endocrinol. , vol.13 , pp. 195-207
    • Byun, D.J.1    Wolchok, J.D.2    Rosenberg, L.M.3    Girotra, M.4
  • 54
    • 85017286857 scopus 로고    scopus 로고
    • Cost-effectiveness of immune checkpoint inhibition in BRAF wild-type advanced melanoma
    • 28221865,. https://doi.org/,. PMID
    • Kohn CG, Zeichner SB, Chen Q, Montero AJ, Goldstein DA, Flowers CR. Cost-effectiveness of immune checkpoint inhibition in BRAF wild-type advanced melanoma. J Clin Oncol. 2017; 35:1194-202. https://doi.org/10.1200/JCO.2016.69.6336. PMID:28221865
    • (2017) J Clin Oncol. , vol.35 , pp. 1194-1202
    • Kohn, C.G.1    Zeichner, S.B.2    Chen, Q.3    Montero, A.J.4    Goldstein, D.A.5    Flowers, C.R.6
  • 55
    • 84937605130 scopus 로고    scopus 로고
    • Toxicities of immunotherapy for the practitioner
    • 25918278,. https://doi.org/,. PMID
    • Weber JS, Yang JC, Atkins MB, Disis ML. Toxicities of immunotherapy for the practitioner. J Clin Oncol. 2015; 33:2092-9. https://doi.org/10.1200/JCO.2014.60.0379. PMID:25918278
    • (2015) J Clin Oncol. , vol.33 , pp. 2092-2099
    • Weber, J.S.1    Yang, J.C.2    Atkins, M.B.3    Disis, M.L.4
  • 56
    • 84975728236 scopus 로고    scopus 로고
    • Management of toxicities of immune checkpoint inhibitors
    • 26874776,. https://doi.org/,. PMID
    • Spain L, Diem S, Larkin J. Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev. 2016; 44:51-60. https://doi.org/10.1016/j.ctrv.2016.02.001. PMID:26874776
    • (2016) Cancer Treat Rev. , vol.44 , pp. 51-60
    • Spain, L.1    Diem, S.2    Larkin, J.3
  • 57
    • 84963621254 scopus 로고    scopus 로고
    • Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
    • 27079802,. https://doi.org/,. PMID
    • Topalian SL, Taube JM, Anders RA, Pardoll DM. Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer. 2016; 16:275-87. https://doi.org/10.1038/nrc.2016.36. PMID:27079802
    • (2016) Nat Rev Cancer. , vol.16 , pp. 275-287
    • Topalian, S.L.1    Taube, J.M.2    Anders, R.A.3    Pardoll, D.M.4
  • 58
    • 85010972085 scopus 로고    scopus 로고
    • IFN signaling and ICB resistance: Time is on tumor's side
    • 28718428,. https://doi.org/,. PMID
    • Lopez-Soto A, Gonzalez S, Folgueras AR. IFN signaling and ICB resistance: Time is on tumor's side. Trends Cancer. 2017; 3:161-3. https://doi.org/10.1016/j.trecan.2017.01.004. PMID:28718428
    • (2017) Trends Cancer. , vol.3 , pp. 161-163
    • Lopez-Soto, A.1    Gonzalez, S.2    Folgueras, A.R.3
  • 61
    • 85040734981 scopus 로고    scopus 로고
    • Towards precision radiotherapy for use with immune checkpoint blockers
    • 28751442,. https://doi.org/,. PMID
    • Vanpouille-Box C, Formenti SC, Demaria S. Towards precision radiotherapy for use with immune checkpoint blockers. Clin Cancer Res. 2017. https://doi.org/10.1158/1078-0432.CCR-16-0037. PMID:28751442
    • (2017) Clin Cancer Res.
    • Vanpouille-Box, C.1    Formenti, S.C.2    Demaria, S.3
  • 62
    • 85024882100 scopus 로고    scopus 로고
    • Biomarkers of response to PD-1/PD-L1 inhibition
    • 28693793,. https://doi.org/,. PMID
    • Maleki Vareki S, Garrigos C, Duran I. Biomarkers of response to PD-1/PD-L1 inhibition. Crit Rev Oncol Hematol. 2017; 116:116-24. https://doi.org/10.1016/j.critrevonc.2017.06.001. PMID:28693793
    • (2017) Crit Rev Oncol Hematol. , vol.116 , pp. 116-124
    • Maleki Vareki, S.1    Garrigos, C.2    Duran, I.3
  • 63
    • 85008395037 scopus 로고    scopus 로고
    • Dynamic versus static biomarkers in cancer immune checkpoint blockade: Unravelling complexity
    • 28057932,. https://doi.org/,. PMID
    • Lesterhuis WJ, Bosco A, Millward MJ, Small M, Nowak AK, Lake RA. Dynamic versus static biomarkers in cancer immune checkpoint blockade: Unravelling complexity. Nat Rev Drug Discov. 2017; 16:264-72. https://doi.org/10.1038/nrd.2016.233. PMID:28057932
    • (2017) Nat Rev Drug Discov. , vol.16 , pp. 264-272
    • Lesterhuis, W.J.1    Bosco, A.2    Millward, M.J.3    Small, M.4    Nowak, A.K.5    Lake, R.A.6
  • 64
    • 85003475383 scopus 로고    scopus 로고
    • Predictive biomarkers for checkpoint inhibitor-based immunotherapy
    • 27924752,. https://doi.org/,. PMID
    • Gibney GT, Weiner LM, Atkins MB. Predictive biomarkers for checkpoint inhibitor-based immunotherapy. Lancet Oncol. 2016; 17:e542-51. https://doi.org/10.1016/S1470-2045(16)30406-5. PMID:27924752
    • (2016) Lancet Oncol. , vol.17 , pp. e542-e551
    • Gibney, G.T.1    Weiner, L.M.2    Atkins, M.B.3
  • 65
    • 85013836274 scopus 로고    scopus 로고
    • Targeting neoantigens to augment antitumour immunity
    • 28233802,. https://doi.org/,. PMID
    • Yarchoan M, Johnson BA, 3rd, Lutz ER, Laheru DA, Jaffee EM. Targeting neoantigens to augment antitumour immunity. Nat Rev Cancer. 2017; 17:209-22. https://doi.org/10.1038/nrc.2016.154. PMID:28233802
    • (2017) Nat Rev Cancer. , vol.17 , pp. 209-222
    • Yarchoan, M.1    Johnson, B.A.2    Lutz, E.R.3    Laheru, D.A.4    Jaffee, E.M.5
  • 67
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
    • 26712084, et al.,. https://doi.org/,. PMID
    • Herbst RS, Baas P, Kim DW, Felip E, Perez-Gracia JL, Han JY, Molina J, Kim JH, Arvis CD, Ahn MJ, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial. Lancet. 2016; 387:1540-50. https://doi.org/10.1016/S0140-6736(15)01281-7. PMID:26712084
    • (2016) Lancet. , vol.387 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3    Felip, E.4    Perez-Gracia, J.L.5    Han, J.Y.6    Molina, J.7    Kim, J.H.8    Arvis, C.D.9    Ahn, M.J.10
  • 68
    • 84964746711 scopus 로고    scopus 로고
    • PD-L1 expression as predictive biomarker in patients with NSCLC: A pooled analysis
    • 26918451, et al.,. https://doi.org/,. PMID
    • Passiglia F, Bronte G, Bazan V, Natoli C, Rizzo S, Galvano A, Listi A, Cicero G, Rolfo C, Santini D, et al. PD-L1 expression as predictive biomarker in patients with NSCLC: A pooled analysis. Oncotarget. 2016; 7:19738-47. https://doi.org/10.18632/oncotarget.7582. PMID:26918451
    • (2016) Oncotarget. , vol.7 , pp. 19738-19747
    • Passiglia, F.1    Bronte, G.2    Bazan, V.3    Natoli, C.4    Rizzo, S.5    Galvano, A.6    Listi, A.7    Cicero, G.8    Rolfo, C.9    Santini, D.10
  • 69
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • 25765070, et al.,. https://doi.org/,. PMID
    • Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, Lee W, Yuan J, Wong P, Ho TS, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015; 348:124-8. https://doi.org/10.1126/science.aaa1348. PMID:25765070
    • (2015) Science. , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6    Lee, W.7    Yuan, J.8    Wong, P.9    Ho, T.S.10
  • 72
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • 25838375,. https://doi.org/,. PMID
    • Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015; 348:69-74. https://doi.org/10.1126/science.aaa4971. PMID:25838375
    • (2015) Science. , vol.348 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 74
    • 84999142201 scopus 로고    scopus 로고
    • Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors
    • 27837027, et al.,. https://doi.org/,. PMID
    • Danilova L, Wang H, Sunshine J, Kaunitz GJ, Cottrell TR, Xu H, Esandrio J, Anders RA, Cope L, Pardoll DM, et al. Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors. Proc Natl Acad Sci U S A. 2016; 113:E7769-77. https://doi.org/10.1073/pnas.1607836113. PMID:27837027
    • (2016) Proc Natl Acad Sci U S A. , vol.113 , pp. E7769-E7777
    • Danilova, L.1    Wang, H.2    Sunshine, J.3    Kaunitz, G.J.4    Cottrell, T.R.5    Xu, H.6    Esandrio, J.7    Anders, R.A.8    Cope, L.9    Pardoll, D.M.10
  • 75
    • 85026829397 scopus 로고    scopus 로고
    • PD-1/PD-L blockade in gastrointestinal cancers: Lessons learned and the road toward precision immunotherapy
    • 28774337,. https://doi.org/,. PMID
    • Long J, Lin J, Wang A, Wu L, Zheng Y, Yang X, Wan X, Xu H, Chen S, Zhao H. PD-1/PD-L blockade in gastrointestinal cancers: Lessons learned and the road toward precision immunotherapy. J Hematol Oncol. 2017; 10:146. https://doi.org/10.1186/s13045-017-0511-2. PMID:28774337
    • (2017) J Hematol Oncol. , vol.10 , pp. 146
    • Long, J.1    Lin, J.2    Wang, A.3    Wu, L.4    Zheng, Y.5    Yang, X.6    Wan, X.7    Xu, H.8    Chen, S.9    Zhao, H.10
  • 76
    • 85014519754 scopus 로고    scopus 로고
    • Precision medicine driven by cancer systems biology
    • 28265786,. https://doi.org/,. PMID
    • Filipp FV. Precision medicine driven by cancer systems biology. Cancer Metastasis Rev. 2017; 36:91-108. https://doi.org/10.1007/s10555-017-9662-4. PMID:28265786
    • (2017) Cancer Metastasis Rev. , vol.36 , pp. 91-108
    • Filipp, F.V.1
  • 78
    • 84988733651 scopus 로고    scopus 로고
    • Promoter methylation of the immune checkpoint receptor PD-1 (PDCD1) is an independent prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy
    • 27853645,. https://doi.org/,. PMID
    • Goltz D, Gevensleben H, Dietrich J, Ellinger J, Landsberg J, Kristiansen G, Dietrich D. Promoter methylation of the immune checkpoint receptor PD-1 (PDCD1) is an independent prognostic biomarker for biochemical recurrence-free survival in prostate cancer patients following radical prostatectomy. Oncoimmunology. 2016; 5:e1221555. https://doi.org/10.1080/2162402X.2016.1221555. PMID:27853645
    • (2016) Oncoimmunology. , vol.5 , pp. e1221555
    • Goltz, D.1    Gevensleben, H.2    Dietrich, J.3    Ellinger, J.4    Landsberg, J.5    Kristiansen, G.6    Dietrich, D.7
  • 79
    • 85021074576 scopus 로고    scopus 로고
    • De Novo epigenetic programs inhibit PD-1 blockade-mediated T cell rejuvenation
    • 28648661, et al.,. https://doi.org/,. PMID
    • Ghoneim HE, Fan Y, Moustaki A, Abdelsamed HA, Dash P, Dogra P, Carter R, Awad W, Neale G, Thomas PG, et al. De Novo epigenetic programs inhibit PD-1 blockade-mediated T cell rejuvenation. Cell. 2017; 170:142-57 e19. https://doi.org/10.1016/j.cell.2017.06.007. PMID:28648661
    • (2017) Cell. , vol.170 , pp. 142-57 e19
    • Ghoneim, H.E.1    Fan, Y.2    Moustaki, A.3    Abdelsamed, H.A.4    Dash, P.5    Dogra, P.6    Carter, R.7    Awad, W.8    Neale, G.9    Thomas, P.G.10
  • 80
    • 84933277745 scopus 로고    scopus 로고
    • Type I interferons in anticancer immunity
    • 26027717,. https://doi.org/,. PMID
    • Zitvogel L, Galluzzi L, Kepp O, Smyth MJ, Kroemer G. Type I interferons in anticancer immunity. Nat Rev Immunol. 2015; 15:405-14. https://doi.org/10.1038/nri3845. PMID:26027717
    • (2015) Nat Rev Immunol. , vol.15 , pp. 405-414
    • Zitvogel, L.1    Galluzzi, L.2    Kepp, O.3    Smyth, M.J.4    Kroemer, G.5
  • 83
    • 85001996779 scopus 로고    scopus 로고
    • Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade
    • 27912061, et al.,. https://doi.org/,. PMID
    • Benci JL, Xu B, Qiu Y, Wu TJ, Dada H, Twyman-Saint\s Victor C, Cucolo L, Lee DS, Pauken KE, Huang AC, et al. Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade. Cell. 2016; 167:1540-54 e12. https://doi.org/10.1016/j.cell.2016.11.022. PMID:27912061
    • (2016) Cell. , vol.167 , pp. 1540-54 e12
    • Benci, J.L.1    Xu, B.2    Qiu, Y.3    Wu, T.J.4    Dada, H.5    Twyman-Saint, C.6    Cucolo, L.7    Lee, D.S.8    Pauken, K.E.9    Huang, A.C.10
  • 84
    • 85027055233 scopus 로고    scopus 로고
    • Interferon gamma modulates sensitivity of CML cells to tyrosine kinase inhibitors
    • 26942083,. https://doi.org/,. PMID
    • Held SA, Heine A, Kesper AR, Schonberg K, Beckers A, Wolf D, Brossart P. Interferon gamma modulates sensitivity of CML cells to tyrosine kinase inhibitors. Oncoimmunology. 2016; 5:e1065368. https://doi.org/10.1080/2162402X.2015.1065368. PMID:26942083
    • (2016) Oncoimmunology. , vol.5 , pp. e1065368
    • Held, S.A.1    Heine, A.2    Kesper, A.R.3    Schonberg, K.4    Beckers, A.5    Wolf, D.6    Brossart, P.7
  • 87
    • 84959422997 scopus 로고    scopus 로고
    • Interferon gamma/NADPH oxidase defense system in immunity and cancer
    • 27057461,. https://doi.org/,. PMID
    • Hodny Z, Reinis M, Hubackova S, Vasicova P, Bartek J. Interferon gamma/NADPH oxidase defense system in immunity and cancer. Oncoimmunology. 2016; 5:e1080416. https://doi.org/10.1080/2162402X.2015.1080416. PMID:27057461
    • (2016) Oncoimmunology. , vol.5 , pp. e1080416
    • Hodny, Z.1    Reinis, M.2    Hubackova, S.3    Vasicova, P.4    Bartek, J.5
  • 88
  • 89
    • 84996605806 scopus 로고    scopus 로고
    • Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade
    • 28123870,. https://doi.org/,. PMID
    • Eissler N, Mao Y, Brodin D, Reutersward P, Andersson Svahn H, Johnsen JI, Kiessling R, Kogner P. Regulation of myeloid cells by activated T cells determines the efficacy of PD-1 blockade. Oncoimmunology. 2016; 5:e1232222. https://doi.org/10.1080/2162402X.2016.1232222. PMID:28123870
    • (2016) Oncoimmunology. , vol.5 , pp. e1232222
    • Eissler, N.1    Mao, Y.2    Brodin, D.3    Reutersward, P.4    Andersson Svahn, H.5    Johnsen, J.I.6    Kiessling, R.7    Kogner, P.8
  • 90
    • 85007499773 scopus 로고    scopus 로고
    • The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells
    • 28123883,. https://doi.org/,. PMID
    • Lu C, Redd PS, Lee JR, Savage N, Liu K. The expression profiles and regulation of PD-L1 in tumor-induced myeloid-derived suppressor cells. Oncoimmunology. 2016; 5:e1247135. https://doi.org/10.1080/2162402X.2016.1247135. PMID:28123883
    • (2016) Oncoimmunology. , vol.5 , pp. e1247135
    • Lu, C.1    Redd, P.S.2    Lee, J.R.3    Savage, N.4    Liu, K.5
  • 91
    • 84938723220 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy
    • 25949858,. https://doi.org/,. PMID
    • Draghiciu O, Lubbers J, Nijman HW, Daemen T. Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy. Oncoimmunology. 2015; 4:e954829. https://doi.org/10.4161/21624011.2014.954829. PMID:25949858
    • (2015) Oncoimmunology. , vol.4 , pp. e954829
    • Draghiciu, O.1    Lubbers, J.2    Nijman, H.W.3    Daemen, T.4
  • 92
    • 84961666207 scopus 로고    scopus 로고
    • PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity
    • 27141339,. https://doi.org/,. PMID
    • Lim TS, Chew V, Sieow JL, Goh S, Yeong JP, Soon AL, Ricciardi-Castagnoli P. PD-1 expression on dendritic cells suppresses CD8+ T cell function and antitumor immunity. Oncoimmunology. 2016; 5:e1085146. https://doi.org/10.1080/2162402X.2015.1085146. PMID:27141339
    • (2016) Oncoimmunology. , vol.5 , pp. e1085146
    • Lim, T.S.1    Chew, V.2    Sieow, J.L.3    Goh, S.4    Yeong, J.P.5    Soon, A.L.6    Ricciardi-Castagnoli, P.7
  • 96
    • 84991619059 scopus 로고    scopus 로고
    • Immunogenic cell death in cancer and infectious disease
    • 27748397,. https://doi.org/,. PMID
    • Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2017; 17:97-111. https://doi.org/10.1038/nri.2016.107. PMID:27748397
    • (2017) Nat Rev Immunol. , vol.17 , pp. 97-111
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 98
    • 84956607773 scopus 로고    scopus 로고
    • Immunological effects of conventional chemotherapy and targeted anticancer agents
    • 26678337,. https://doi.org/,. PMID
    • Galluzzi L, Buque A, Kepp O, Zitvogel L, Kroemer G. Immunological effects of conventional chemotherapy and targeted anticancer agents. Cancer Cell. 2015; 28:690-714. https://doi.org/10.1016/j.ccell.2015.10.012. PMID:26678337
    • (2015) Cancer Cell. , vol.28 , pp. 690-714
    • Galluzzi, L.1    Buque, A.2    Kepp, O.3    Zitvogel, L.4    Kroemer, G.5
  • 99
    • 84978499806 scopus 로고    scopus 로고
    • Chemotherapy and immunotherapy: A close interplay to fight cancer?
    • 27622046,. https://doi.org/,. PMID
    • Hanoteau A, Moser M. Chemotherapy and immunotherapy: A close interplay to fight cancer? Oncoimmunology. 2016; 5:e1190061. https://doi.org/10.1080/2162402X.2016.1190061. PMID:27622046
    • (2016) Oncoimmunology. , vol.5 , pp. e1190061
    • Hanoteau, A.1    Moser, M.2
  • 101
    • 84960395521 scopus 로고    scopus 로고
    • Intratumoral LIGHT restores pericyte contractile properties and vessel integrity
    • 26711337,. https://doi.org/,. PMID
    • Johansson-Percival A, Li ZJ, Lakhiani DD, He B, Wang X, Hamzah J, Ganss R. Intratumoral LIGHT restores pericyte contractile properties and vessel integrity. Cell Rep. 2015; 13:2687-98. https://doi.org/10.1016/j.celrep.2015.12.004. PMID:26711337
    • (2015) Cell Rep. , vol.13 , pp. 2687-2698
    • Johansson-Percival, A.1    Li, Z.J.2    Lakhiani, D.D.3    He, B.4    Wang, X.5    Hamzah, J.6    Ganss, R.7
  • 102
    • 85011664103 scopus 로고    scopus 로고
    • Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment-evidence to turn on the LIGHT
    • 26942091,. https://doi.org/,. PMID
    • Maker AV. Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment-evidence to turn on the LIGHT. Oncoimmunology. 2016; 5:e1069937. https://doi.org/10.1080/2162402X.2015.1069937. PMID:26942091
    • (2016) Oncoimmunology. , vol.5 , pp. e1069937
    • Maker, A.V.1
  • 104
    • 84924352771 scopus 로고    scopus 로고
    • Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT
    • 25512551,. https://doi.org/,. PMID
    • Holmes TD, Wilson EB, Black EV, Benest AV, Vaz C, Tan B, Tanavde VM, Cook GP. Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT. Proc Natl Acad Sci U S A. 2014; 111:E5688-96. https://doi.org/10.1073/pnas.1411072112. PMID:25512551
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , pp. E5688-E5696
    • Holmes, T.D.1    Wilson, E.B.2    Black, E.V.3    Benest, A.V.4    Vaz, C.5    Tan, B.6    Tanavde, V.M.7    Cook, G.P.8
  • 105
    • 84962921798 scopus 로고    scopus 로고
    • Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade
    • 26977880,. https://doi.org/,. PMID
    • Tang H, Wang Y, Chlewicki LK, Zhang Y, Guo J, Liang W, Wang J, Wang X, Fu YX. Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade. Cancer Cell. 2016; 29:285-96. https://doi.org/10.1016/j.ccell.2016.02.004. PMID:26977880
    • (2016) Cancer Cell. , vol.29 , pp. 285-296
    • Tang, H.1    Wang, Y.2    Chlewicki, L.K.3    Zhang, Y.4    Guo, J.5    Liang, W.6    Wang, J.7    Wang, X.8    Fu, Y.X.9
  • 108
    • 84928013457 scopus 로고    scopus 로고
    • Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2
    • 25873172, et al.,. https://doi.org/,. PMID
    • Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, et al. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell. 2015; 27:489-501. https://doi.org/10.1016/j.ccell.2015.03.004. PMID:25873172
    • (2015) Cancer Cell. , vol.27 , pp. 489-501
    • Zhu, E.F.1    Gai, S.A.2    Opel, C.F.3    Kwan, B.H.4    Surana, R.5    Mihm, M.C.6    Kauke, M.J.7    Moynihan, K.D.8    Angelini, A.9    Williams, R.T.10
  • 109
    • 84928591321 scopus 로고    scopus 로고
    • The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
    • 25882245,. https://doi.org/,. PMID
    • Klatzmann D, Abbas AK. The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases. Nat Rev Immunol. 2015; 15:283-94. https://doi.org/10.1038/nri3823. PMID:25882245
    • (2015) Nat Rev Immunol. , vol.15 , pp. 283-294
    • Klatzmann, D.1    Abbas, A.K.2
  • 111
    • 84857646605 scopus 로고    scopus 로고
    • The role of interleukin-2 during homeostasis and activation of the immune system
    • 22343569,. PMID
    • Boyman O, Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat Rev Immunol. 2012; 12:180-90. PMID:22343569
    • (2012) Nat Rev Immunol. , vol.12 , pp. 180-190
    • Boyman, O.1    Sprent, J.2
  • 112
    • 84961575875 scopus 로고    scopus 로고
    • IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?
    • 27141363,. https://doi.org/,. PMID
    • Tomala J, Kovar M. IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy? Oncoimmunology. 2016; 5:e1102829. https://doi.org/10.1080/2162402X.2015.1102829. PMID:27141363
    • (2016) Oncoimmunology. , vol.5 , pp. e1102829
    • Tomala, J.1    Kovar, M.2
  • 113
    • 84897954314 scopus 로고    scopus 로고
    • Structure-based programming of lymph-node targeting in molecular vaccines
    • 24531764,. https://doi.org/,. PMID
    • Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. Structure-based programming of lymph-node targeting in molecular vaccines. Nature. 2014; 507:519-22. https://doi.org/10.1038/nature12978. PMID:24531764
    • (2014) Nature. , vol.507 , pp. 519-522
    • Liu, H.1    Moynihan, K.D.2    Zheng, Y.3    Szeto, G.L.4    Li, A.V.5    Huang, B.6    Van Egeren, D.S.7    Park, C.8    Irvine, D.J.9
  • 115
    • 84944474622 scopus 로고    scopus 로고
    • Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma
    • 26155388,. https://doi.org/,. PMID
    • Combe P, de Guillebon E, Thibault C, Granier C, Tartour E, Oudard S. Trial Watch: Therapeutic vaccines in metastatic renal cell carcinoma. Oncoimmunology. 2015; 4:e1001236. https://doi.org/10.1080/2162402X.2014.1001236. PMID:26155388
    • (2015) Oncoimmunology. , vol.4 , pp. e1001236
    • Combe, P.1    de Guillebon, E.2    Thibault, C.3    Granier, C.4    Tartour, E.5    Oudard, S.6
  • 116
    • 84955410497 scopus 로고    scopus 로고
    • Critical issues in cancer vaccine trial design
    • 26392010,. https://doi.org/,. PMID
    • Clifton GT, Kohrt HE, Peoples GE. Critical issues in cancer vaccine trial design. Vaccine. 2015; 33:7386-92. https://doi.org/10.1016/j.vaccine.2015.09.019. PMID:26392010
    • (2015) Vaccine. , vol.33 , pp. 7386-7392
    • Clifton, G.T.1    Kohrt, H.E.2    Peoples, G.E.3
  • 117
    • 84992315668 scopus 로고    scopus 로고
    • Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses
    • 27775706, et al.,. https://doi.org/,. PMID
    • Moynihan KD, Opel CF, Szeto GL, Tzeng A, Zhu EF, Engreitz JM, Williams RT, Rakhra K, Zhang MH, Rothschilds AM, et al. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Nat Med. 2016; 22:1402-10. https://doi.org/10.1038/nm.4200. PMID:27775706
    • (2016) Nat Med. , vol.22 , pp. 1402-1410
    • Moynihan, K.D.1    Opel, C.F.2    Szeto, G.L.3    Tzeng, A.4    Zhu, E.F.5    Engreitz, J.M.6    Williams, R.T.7    Rakhra, K.8    Zhang, M.H.9    Rothschilds, A.M.10
  • 119
    • 85014686816 scopus 로고    scopus 로고
    • Biological functions of CDK5 and potential CDK5 targeted clinical treatments
    • 28077789,. PMID
    • Shupp A, Casimiro MC, Pestell RG. Biological functions of CDK5 and potential CDK5 targeted clinical treatments. Oncotarget. 2017; 8:17373-82. PMID:28077789
    • (2017) Oncotarget. , vol.8 , pp. 17373-17382
    • Shupp, A.1    Casimiro, M.C.2    Pestell, R.G.3
  • 120
    • 84994102504 scopus 로고    scopus 로고
    • The emerging role of Cdk5 in cancer
    • 27917404,. https://doi.org/,. PMID
    • Pozo K, Bibb JA. The emerging role of Cdk5 in cancer. Trends Cancer. 2016; 2:606-18. https://doi.org/10.1016/j.trecan.2016.09.001. PMID:27917404
    • (2016) Trends Cancer. , vol.2 , pp. 606-618
    • Pozo, K.1    Bibb, J.A.2
  • 122
    • 85104494373 scopus 로고    scopus 로고
    • CDK5 promotes tumor immune evasion via PD-L1 upregulation
    • https://doi.org
    • CDK5 promotes tumor immune evasion via PD-L1 upregulation. Cancer Discov. 2016; 6:943. https://doi.org/10.1158/2159-8290.CD-RW2016-141
    • (2016) Cancer Discov. , vol.6 , pp. 943
  • 124
    • 84964598888 scopus 로고    scopus 로고
    • Frameshift mutations, neoantigens and tumor-specific CD8(+) T cells in microsatellite unstable colorectal cancers
    • 27467916,. https://doi.org/,. PMID
    • Maby P, Galon J, Latouche JB. Frameshift mutations, neoantigens and tumor-specific CD8(+) T cells in microsatellite unstable colorectal cancers. Oncoimmunology. 2016; 5:e1115943. https://doi.org/10.1080/2162402X.2015.1115943. PMID:27467916
    • (2016) Oncoimmunology. , vol.5 , pp. e1115943
    • Maby, P.1    Galon, J.2    Latouche, J.B.3
  • 125
    • 84866742560 scopus 로고    scopus 로고
    • TGFbeta signalling in context
    • 22992590,. https://doi.org/,. PMID
    • Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol. 2012; 13:616-30. https://doi.org/10.1038/nrm3434. PMID:22992590
    • (2012) Nat Rev Mol Cell Biol. , vol.13 , pp. 616-630
    • Massague, J.1
  • 126
    • 84962850014 scopus 로고    scopus 로고
    • MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition
    • 27141403,. https://doi.org/,. PMID
    • David JM, Hamilton DH, Palena C. MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition. Oncoimmunology. 2016; 5:e1117738. https://doi.org/10.1080/2162402X.2015.1117738. PMID:27141403
    • (2016) Oncoimmunology. , vol.5 , pp. e1117738
    • David, J.M.1    Hamilton, D.H.2    Palena, C.3
  • 127
    • 84955515590 scopus 로고    scopus 로고
    • Metastatic colonization by circulating tumour cells
    • 26791720,. https://doi.org/,. PMID
    • Massague J, Obenauf AC. Metastatic colonization by circulating tumour cells. Nature. 2016; 529:298-306. https://doi.org/10.1038/nature17038. PMID:26791720
    • (2016) Nature. , vol.529 , pp. 298-306
    • Massague, J.1    Obenauf, A.C.2
  • 128
    • 84994083581 scopus 로고    scopus 로고
    • Low-molecular-weight hyaluronan (LMW-HA) accelerates lymph node metastasis of melanoma cells by inducing disruption of lymphatic intercellular adhesion
    • 27999746,. https://doi.org/,. PMID
    • Du Y, Cao M, Liu Y, He Y, Yang C, Wu M, Zhang G, Gao F. Low-molecular-weight hyaluronan (LMW-HA) accelerates lymph node metastasis of melanoma cells by inducing disruption of lymphatic intercellular adhesion. Oncoimmunology. 2016; 5:e1232235. https://doi.org/10.1080/2162402X.2016.1232235. PMID:27999746
    • (2016) Oncoimmunology. , vol.5 , pp. e1232235
    • Du, Y.1    Cao, M.2    Liu, Y.3    He, Y.4    Yang, C.5    Wu, M.6    Zhang, G.7    Gao, F.8
  • 129
    • 84944463669 scopus 로고    scopus 로고
    • Understanding high endothelial venules: Lessons for cancer immunology
    • 26155419,. https://doi.org/,. PMID
    • Ager A, May MJ. Understanding high endothelial venules: Lessons for cancer immunology. Oncoimmunology. 2015; 4:e1008791. https://doi.org/10.1080/2162402X.2015.1008791. PMID:26155419
    • (2015) Oncoimmunology. , vol.4 , pp. e1008791
    • Ager, A.1    May, M.J.2
  • 130
    • 84984694266 scopus 로고    scopus 로고
    • The biology and function of fibroblasts in cancer
    • 27550820,. https://doi.org/,. PMID
    • Kalluri R. The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016; 16:582-98. https://doi.org/10.1038/nrc.2016.73. PMID:27550820
    • (2016) Nat Rev Cancer. , vol.16 , pp. 582-598
    • Kalluri, R.1
  • 131
    • 84945451852 scopus 로고    scopus 로고
    • Immunological hallmarks of stromal cells in the tumour microenvironment
    • 26471778,. https://doi.org/,. PMID
    • Turley SJ, Cremasco V, Astarita JL. Immunological hallmarks of stromal cells in the tumour microenvironment. Nat Rev Immunol. 2015; 15:669-82. https://doi.org/10.1038/nri3902. PMID:26471778
    • (2015) Nat Rev Immunol. , vol.15 , pp. 669-682
    • Turley, S.J.1    Cremasco, V.2    Astarita, J.L.3
  • 132
    • 84922333220 scopus 로고    scopus 로고
    • Remodelling the extracellular matrix in development and disease
    • 25415508,. https://doi.org/,. PMID
    • Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol. 2014; 15:786-801. https://doi.org/10.1038/nrm3904. PMID:25415508
    • (2014) Nat Rev Mol Cell Biol. , vol.15 , pp. 786-801
    • Bonnans, C.1    Chou, J.2    Werb, Z.3
  • 133
  • 134
    • 85029290103 scopus 로고    scopus 로고
    • Microenvironmental regulation of tumour angiogenesis
    • 28706266,. https://doi.org/,. PMID
    • De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017; 17:457-74. https://doi.org/10.1038/nrc.2017.51. PMID:28706266
    • (2017) Nat Rev Cancer. , vol.17 , pp. 457-474
    • De Palma, M.1    Biziato, D.2    Petrova, T.V.3
  • 135
    • 84954569855 scopus 로고    scopus 로고
    • Ten years of anti-vascular endothelial growth factor therapy
    • 26775688,. https://doi.org/,. PMID
    • Ferrara N, Adamis AP. Ten years of anti-vascular endothelial growth factor therapy. Nat Rev Drug Discov. 2016; 15:385-403. https://doi.org/10.1038/nrd.2015.17. PMID:26775688
    • (2016) Nat Rev Drug Discov. , vol.15 , pp. 385-403
    • Ferrara, N.1    Adamis, A.P.2
  • 137
    • 85021358886 scopus 로고    scopus 로고
    • Driving to cancer on a four-lane expressway
    • 28668385,. https://doi.org/,. PMID
    • Galluzzi L, Vitale I. Driving to cancer on a four-lane expressway. Trends Genet. 2017; 33:491-2. https://doi.org/10.1016/j.tig.2017.06.003. PMID:28668385
    • (2017) Trends Genet. , vol.33 , pp. 491-492
    • Galluzzi, L.1    Vitale, I.2
  • 138
    • 85022069589 scopus 로고    scopus 로고
    • Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: A pan-cancer analysis
    • 28694034, et al.,. https://doi.org/,. PMID
    • Turajlic S, Litchfield K, Xu H, Rosenthal R, McGranahan N, Reading JL, Wong YNS, Rowan A, Kanu N, Al Bakir M, et al. Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: A pan-cancer analysis. Lancet Oncol. 2017; 18:1009-21. https://doi.org/10.1016/S1470-2045(17)30516-8. PMID:28694034
    • (2017) Lancet Oncol. , vol.18 , pp. 1009-1021
    • Turajlic, S.1    Litchfield, K.2    Xu, H.3    Rosenthal, R.4    McGranahan, N.5    Reading, J.L.6    Wong, Y.N.S.7    Rowan, A.8    Kanu, N.9    Al Bakir, M.10
  • 142
    • 85029310172 scopus 로고    scopus 로고
    • Fragile sites in cancer: More than meets the eye
    • 28740117,. https://doi.org/,. PMID
    • Glover TW, Wilson TE, Arlt MF. Fragile sites in cancer: More than meets the eye. Nat Rev Cancer. 2017; 17:489-501. https://doi.org/10.1038/nrc.2017.52. PMID:28740117
    • (2017) Nat Rev Cancer. , vol.17 , pp. 489-501
    • Glover, T.W.1    Wilson, T.E.2    Arlt, M.F.3
  • 143
    • 84979999678 scopus 로고    scopus 로고
    • Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103(+) dendritic cells in late-stage ovarian cancer
    • 27622059,. https://doi.org/,. PMID
    • Flies DB, Higuchi T, Harris JC, Jha V, Gimotty PA, Adams SF. Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103(+) dendritic cells in late-stage ovarian cancer. Oncoimmunology. 2016; 5:e1185583. https://doi.org/10.1080/2162402X.2016.1185583. PMID:27622059
    • (2016) Oncoimmunology. , vol.5 , pp. e1185583
    • Flies, D.B.1    Higuchi, T.2    Harris, J.C.3    Jha, V.4    Gimotty, P.A.5    Adams, S.F.6
  • 144
    • 84940546286 scopus 로고    scopus 로고
    • Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103- and XCR1+CD103+ dendritic cells
    • 26405572, et al.,. https://doi.org/,. PMID
    • Wylie B, Seppanen E, Xiao K, Zemek R, Zanker D, Prato S, Foley B, Hart PH, Kroczek RA, Chen W, et al. Cross-presentation of cutaneous melanoma antigen by migratory XCR1+CD103- and XCR1+CD103+ dendritic cells. Oncoimmunology. 2015; 4:e1019198. https://doi.org/10.1080/2162402X.2015.1019198. PMID:26405572
    • (2015) Oncoimmunology. , vol.4 , pp. e1019198
    • Wylie, B.1    Seppanen, E.2    Xiao, K.3    Zemek, R.4    Zanker, D.5    Prato, S.6    Foley, B.7    Hart, P.H.8    Kroczek, R.A.9    Chen, W.10
  • 146
    • 84975795348 scopus 로고    scopus 로고
    • The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder
    • 27467953, et al.,. https://doi.org/,. PMID
    • Baras AS, Drake C, Liu JJ, Gandhi N, Kates M, Hoque MO, Meeker A, Hahn N, Taube JM, Schoenberg MP, et al. The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder. Oncoimmunology. 2016; 5:e1134412. https://doi.org/10.1080/2162402X.2015.1134412. PMID:27467953
    • (2016) Oncoimmunology. , vol.5 , pp. e1134412
    • Baras, A.S.1    Drake, C.2    Liu, J.J.3    Gandhi, N.4    Kates, M.5    Hoque, M.O.6    Meeker, A.7    Hahn, N.8    Taube, J.M.9    Schoenberg, M.P.10
  • 148
    • 84943617416 scopus 로고    scopus 로고
    • Natural and therapy-induced immunosurveillance in breast cancer
    • 26444637,. https://doi.org/,. PMID
    • Kroemer G, Senovilla L, Galluzzi L, Andre F, Zitvogel L. Natural and therapy-induced immunosurveillance in breast cancer. Nat Med. 2015; 21:1128-38. https://doi.org/10.1038/nm.3944. PMID:26444637
    • (2015) Nat Med. , vol.21 , pp. 1128-1138
    • Kroemer, G.1    Senovilla, L.2    Galluzzi, L.3    Andre, F.4    Zitvogel, L.5
  • 151
    • 85023641634 scopus 로고    scopus 로고
    • Anticancer effects of the microbiome and its products
    • 28529325,. https://doi.org/,. PMID
    • Zitvogel L, Daillere R, Roberti MP, Routy B, Kroemer G. Anticancer effects of the microbiome and its products. Nat Rev Microbiol. 2017; 15:465-78. https://doi.org/10.1038/nrmicro.2017.44. PMID:28529325
    • (2017) Nat Rev Microbiol. , vol.15 , pp. 465-478
    • Zitvogel, L.1    Daillere, R.2    Roberti, M.P.3    Routy, B.4    Kroemer, G.5
  • 152
    • 84962788254 scopus 로고    scopus 로고
    • Microbiome and anticancer immunosurveillance
    • 27058662,. https://doi.org/,. PMID
    • Zitvogel L, Ayyoub M, Routy B, Kroemer G. Microbiome and anticancer immunosurveillance. Cell. 2016; 165:276-87. https://doi.org/10.1016/j.cell.2016.03.001. PMID:27058662
    • (2016) Cell. , vol.165 , pp. 276-287
    • Zitvogel, L.1    Ayyoub, M.2    Routy, B.3    Kroemer, G.4
  • 155
    • 85019207258 scopus 로고    scopus 로고
    • Epigenetics and immunotherapy: The current state of play
    • 28511092,. https://doi.org/,. PMID
    • Dunn J, Rao S. Epigenetics and immunotherapy: The current state of play. Mol Immunol. 2017; 87:227-39. https://doi.org/10.1016/j.molimm.2017.04.012. PMID:28511092
    • (2017) Mol Immunol. , vol.87 , pp. 227-239
    • Dunn, J.1    Rao, S.2
  • 157
    • 85019744578 scopus 로고    scopus 로고
    • PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
    • 28514441, et al.,. https://doi.org/,. PMID
    • Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, Tsai JM, Sinha R, Corey D, et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. 2017; 545:495-9. https://doi.org/10.1038/nature22396. PMID:28514441
    • (2017) Nature. , vol.545 , pp. 495-499
    • Gordon, S.R.1    Maute, R.L.2    Dulken, B.W.3    Hutter, G.4    George, B.M.5    McCracken, M.N.6    Gupta, R.7    Tsai, J.M.8    Sinha, R.9    Corey, D.10
  • 158
    • 85028301168 scopus 로고    scopus 로고
    • Drugging the ‘undruggable’ cancer targets
    • 28643779,. https://doi.org/,. PMID
    • Dang CV, Reddy EP, Shokat KM, Soucek L. Drugging the ‘undruggable’ cancer targets. Nat Rev Cancer. 2017; 17:502-8. https://doi.org/10.1038/nrc.2017.36. PMID:28643779
    • (2017) Nat Rev Cancer. , vol.17 , pp. 502-508
    • Dang, C.V.1    Reddy, E.P.2    Shokat, K.M.3    Soucek, L.4
  • 161
  • 162
    • 85016137167 scopus 로고    scopus 로고
    • Immunological mechanisms underneath the efficacy of cancer therapy
    • 27803050,. https://doi.org/,. PMID
    • Galluzzi L, Zitvogel L, Kroemer G. Immunological mechanisms underneath the efficacy of cancer therapy. Cancer Immunol Res. 2016; 4:895-902. https://doi.org/10.1158/2326-6066.CIR-16-0197. PMID:27803050
    • (2016) Cancer Immunol Res. , vol.4 , pp. 895-902
    • Galluzzi, L.1    Zitvogel, L.2    Kroemer, G.3
  • 163
    • 84954466729 scopus 로고    scopus 로고
    • Radiation and immunotherapy as systemic therapy for solid tumors
    • 25949899,. https://doi.org/,. PMID
    • Seyedin SN, Tang C, Welsh JW. Radiation and immunotherapy as systemic therapy for solid tumors. Oncoimmunology. 2015; 4:e986402. https://doi.org/10.4161/2162402X.2014.986402. PMID:25949899
    • (2015) Oncoimmunology. , vol.4 , pp. e986402
    • Seyedin, S.N.1    Tang, C.2    Welsh, J.W.3
  • 164
    • 84995370898 scopus 로고    scopus 로고
    • Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
    • 27845767,. https://doi.org/,. PMID
    • Galluzzi L, Bravo-San Pedro JM, Demaria S, Formenti SC, Kroemer G. Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol. 2017; 14:247-58. https://doi.org/10.1038/nrclinonc.2016.183. PMID:27845767
    • (2017) Nat Rev Clin Oncol. , vol.14 , pp. 247-258
    • Galluzzi, L.1    Bravo-San Pedro, J.M.2    Demaria, S.3    Formenti, S.C.4    Kroemer, G.5
  • 167
    • 84969627158 scopus 로고    scopus 로고
    • Trial Watch-small molecules targeting the immunological tumor microenvironment for cancer therapy
    • 27471617, et al.,. https://doi.org/,. PMID
    • Buque A, Bloy N, Aranda F, Cremer I, Eggermont A, Fridman WH, Fucikova J, Galon J, Spisek R, Tartour E, et al. Trial Watch-small molecules targeting the immunological tumor microenvironment for cancer therapy. Oncoimmunology. 2016; 5:e1149674. https://doi.org/10.1080/2162402X.2016.1149674. PMID:27471617
    • (2016) Oncoimmunology. , vol.5 , pp. e1149674
    • Buque, A.1    Bloy, N.2    Aranda, F.3    Cremer, I.4    Eggermont, A.5    Fridman, W.H.6    Fucikova, J.7    Galon, J.8    Spisek, R.9    Tartour, E.10
  • 168
    • 84940890382 scopus 로고    scopus 로고
    • Big opportunities for small molecules in immuno-oncology
    • 26228631,. https://doi.org/,. PMID
    • Adams JL, Smothers J, Srinivasan R, Hoos A. Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov. 2015; 14:603-22. https://doi.org/10.1038/nrd4596. PMID:26228631
    • (2015) Nat Rev Drug Discov. , vol.14 , pp. 603-622
    • Adams, J.L.1    Smothers, J.2    Srinivasan, R.3    Hoos, A.4
  • 171
    • 84927651609 scopus 로고    scopus 로고
    • Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial
    • 25713437, et al.,. https://doi.org/,. PMID
    • Maio M, Grob JJ, Aamdal S, Bondarenko I, Robert C, Thomas L, Garbe C, Chiarion-Sileni V, Testori A, Chen TT, et al. Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial. J Clin Oncol. 2015; 33:1191-6. https://doi.org/10.1200/JCO.2014.56.6018. PMID:25713437
    • (2015) J Clin Oncol. , vol.33 , pp. 1191-1196
    • Maio, M.1    Grob, J.J.2    Aamdal, S.3    Bondarenko, I.4    Robert, C.5    Thomas, L.6    Garbe, C.7    Chiarion-Sileni, V.8    Testori, A.9    Chen, T.T.10
  • 172
    • 84963629041 scopus 로고    scopus 로고
    • Phase II study of autologous monocyte-derived mRNA electroporated dendritic cells (TriMixDC-MEL) plus ipilimumab in patients with pretreated advanced melanoma
    • 26926680,. https://doi.org/,. PMID
    • Wilgenhof S, Corthals J, Heirman C, van Baren N, Lucas S, Kvistborg P, Thielemans K, Neyns B. Phase II study of autologous monocyte-derived mRNA electroporated dendritic cells (TriMixDC-MEL) plus ipilimumab in patients with pretreated advanced melanoma. J Clin Oncol. 2016; 34:1330-8. https://doi.org/10.1200/JCO.2015.63.4121. PMID:26926680
    • (2016) J Clin Oncol. , vol.34 , pp. 1330-1338
    • Wilgenhof, S.1    Corthals, J.2    Heirman, C.3    van Baren, N.4    Lucas, S.5    Kvistborg, P.6    Thielemans, K.7    Neyns, B.8
  • 173
    • 85011277323 scopus 로고    scopus 로고
    • Health-related quality of life with adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): Secondary outcomes of a multinational, randomised, double-blind, phase 3 trial
    • 28162999, et al.,. https://doi.org/,. PMID
    • Coens C, Suciu S, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, et al. Health-related quality of life with adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): Secondary outcomes of a multinational, randomised, double-blind, phase 3 trial. Lancet Oncol. 2017; 18:393-403. https://doi.org/10.1016/S1470-2045(17)30015-3. PMID:28162999
    • (2017) Lancet Oncol. , vol.18 , pp. 393-403
    • Coens, C.1    Suciu, S.2    Chiarion-Sileni, V.3    Grob, J.J.4    Dummer, R.5    Wolchok, J.D.6    Schmidt, H.7    Hamid, O.8    Robert, C.9    Ascierto, P.A.10
  • 174
  • 175
    • 85016813132 scopus 로고    scopus 로고
    • Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: A randomised, double-blind, multicentre, phase 3 trial
    • 28359784, et al.,. https://doi.org/,. PMID
    • Ascierto PA, Del Vecchio M, Robert C, Mackiewicz A, Chiarion-Sileni V, Arance A, Lebbe C, Bastholt L, Hamid O, Rutkowski P, et al. Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: A randomised, double-blind, multicentre, phase 3 trial. Lancet Oncol. 2017; 18:611-22. https://doi.org/10.1016/S1470-2045(17)30231-0. PMID:28359784
    • (2017) Lancet Oncol. , vol.18 , pp. 611-622
    • Ascierto, P.A.1    Del Vecchio, M.2    Robert, C.3    Mackiewicz, A.4    Chiarion-Sileni, V.5    Arance, A.6    Lebbe, C.7    Bastholt, L.8    Hamid, O.9    Rutkowski, P.10
  • 176
    • 84979599378 scopus 로고    scopus 로고
    • Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma
    • 27298410, et al.,. https://doi.org/,. PMID
    • Puzanov I, Milhem MM, Minor D, Hamid O, Li A, Chen L, Chastain M, Gorski KS, Anderson A, Chou J, et al. Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma. J Clin Oncol. 2016; 34:2619-26. https://doi.org/10.1200/JCO.2016.67.1529. PMID:27298410
    • (2016) J Clin Oncol. , vol.34 , pp. 2619-2626
    • Puzanov, I.1    Milhem, M.M.2    Minor, D.3    Hamid, O.4    Li, A.5    Chen, L.6    Chastain, M.7    Gorski, K.S.8    Anderson, A.9    Chou, J.10
  • 178
    • 84926507093 scopus 로고    scopus 로고
    • Three-year follow-up of advanced melanoma patients who received ipilimumab plus fotemustine in the Italian Network for Tumor Biotherapy (NIBIT)-M1 phase II study
    • 25538176, et al.,. https://doi.org/,. PMID
    • Di Giacomo AM, Ascierto PA, Queirolo P, Pilla L, Ridolfi R, Santinami M, Testori A, Simeone E, Guidoboni M, Maurichi A, et al. Three-year follow-up of advanced melanoma patients who received ipilimumab plus fotemustine in the Italian Network for Tumor Biotherapy (NIBIT)-M1 phase II study. Ann Oncol. 2015; 26:798-803. https://doi.org/10.1093/annonc/mdu577. PMID:25538176
    • (2015) Ann Oncol. , vol.26 , pp. 798-803
    • Di Giacomo, A.M.1    Ascierto, P.A.2    Queirolo, P.3    Pilla, L.4    Ridolfi, R.5    Santinami, M.6    Testori, A.7    Simeone, E.8    Guidoboni, M.9    Maurichi, A.10
  • 179
    • 84997666866 scopus 로고    scopus 로고
    • Phase II study of vemurafenib followed by ipilimumab in patients with previously untreated BRAF-mutated metastatic melanoma
    • 27532019, et al.,. https://doi.org/,. PMID
    • Amin A, Lawson DH, Salama AK, Koon HB, Guthrie T, Jr, Thomas SS, O'Day SJ, Shaheen MF, Zhang B, Francis S, et al. Phase II study of vemurafenib followed by ipilimumab in patients with previously untreated BRAF-mutated metastatic melanoma. J Immunother Cancer. 2016; 4:44. https://doi.org/10.1186/s40425-016-0148-7. PMID:27532019
    • (2016) J Immunother Cancer. , vol.4 , pp. 44
    • Amin, A.1    Lawson, D.H.2    Salama, A.K.3    Koon, H.B.4    Guthrie, T.5    Thomas, S.S.6    O'Day, S.J.7    Shaheen, M.F.8    Zhang, B.9    Francis, S.10
  • 180
    • 84967185844 scopus 로고    scopus 로고
    • Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy
    • 27124339, et al.,. https://doi.org/,. PMID
    • Bowyer S, Prithviraj P, Lorigan P, Larkin J, McArthur G, Atkinson V, Millward M, Khou M, Diem S, Ramanujam S, et al. Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy. Br J Cancer. 2016; 114:1084-9. https://doi.org/10.1038/bjc.2016.107. PMID:27124339
    • (2016) Br J Cancer. , vol.114 , pp. 1084-1089
    • Bowyer, S.1    Prithviraj, P.2    Lorigan, P.3    Larkin, J.4    McArthur, G.5    Atkinson, V.6    Millward, M.7    Khou, M.8    Diem, S.9    Ramanujam, S.10
  • 182
    • 84944896352 scopus 로고    scopus 로고
    • Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma
    • 26407818, et al.,. https://doi.org/,. PMID
    • Yamazaki N, Uhara H, Fukushima S, Uchi H, Shibagaki N, Kiyohara Y, Tsutsumida A, Namikawa K, Okuyama R, Otsuka Y, et al. Phase II study of the immune-checkpoint inhibitor ipilimumab plus dacarbazine in Japanese patients with previously untreated, unresectable or metastatic melanoma. Cancer Chemother Pharmacol. 2015; 76:969-75. https://doi.org/10.1007/s00280-015-2870-0. PMID:26407818
    • (2015) Cancer Chemother Pharmacol. , vol.76 , pp. 969-975
    • Yamazaki, N.1    Uhara, H.2    Fukushima, S.3    Uchi, H.4    Shibagaki, N.5    Kiyohara, Y.6    Tsutsumida, A.7    Namikawa, K.8    Okuyama, R.9    Otsuka, Y.10
  • 184
    • 84991110530 scopus 로고    scopus 로고
    • Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): An open-label, randomised, phase 2 trial
    • 27269740, et al.,. https://doi.org/,. PMID
    • Weber JS, Gibney G, Sullivan RJ, Sosman JA, Slingluff CL, Jr, Lawrence DP, Logan TF, Schuchter LM, Nair S, Fecher L, et al. Sequential administration of nivolumab and ipilimumab with a planned switch in patients with advanced melanoma (CheckMate 064): An open-label, randomised, phase 2 trial. Lancet Oncol. 2016; 17:943-55. https://doi.org/10.1016/S1470-2045(16)30126-7. PMID:27269740
    • (2016) Lancet Oncol. , vol.17 , pp. 943-955
    • Weber, J.S.1    Gibney, G.2    Sullivan, R.J.3    Sosman, J.A.4    Slingluff, C.L.5    Lawrence, D.P.6    Logan, T.F.7    Schuchter, L.M.8    Nair, S.9    Fecher, L.10
  • 185
    • 85011542577 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial
    • 27622997, et al.,. https://doi.org/,. PMID
    • Hodi FS, Chesney J, Pavlick AC, Robert C, Grossmann KF, McDermott DF, Linette GP, Meyer N, Giguere JK, Agarwala SS, et al. Combined nivolumab and ipilimumab versus ipilimumab alone in patients with advanced melanoma: 2-year overall survival outcomes in a multicentre, randomised, controlled, phase 2 trial. Lancet Oncol. 2016; 17:1558-68. https://doi.org/10.1016/S1470-2045(16)30366-7. PMID:27622997
    • (2016) Lancet Oncol. , vol.17 , pp. 1558-1568
    • Hodi, F.S.1    Chesney, J.2    Pavlick, A.C.3    Robert, C.4    Grossmann, K.F.5    McDermott, D.F.6    Linette, G.P.7    Meyer, N.8    Giguere, J.K.9    Agarwala, S.S.10
  • 187
    • 85020774814 scopus 로고    scopus 로고
    • Combined KIT and CTLA-4 blockade in patients with refractory GIST and other advanced sarcomas: A phase Ib study of dasatinib plus ipilimumab
    • 28007774, et al.,. https://doi.org/,. PMID
    • D'Angelo SP, Shoushtari AN, Keohan ML, Dickson MA, Gounder MM, Chi P, Loo JK, Gaffney L, Schneider L, Patel Z, et al. Combined KIT and CTLA-4 blockade in patients with refractory GIST and other advanced sarcomas: A phase Ib study of dasatinib plus ipilimumab. Clin Cancer Res. 2017; 23:2972-80. https://doi.org/10.1158/1078-0432.CCR-16-2349. PMID:28007774
    • (2017) Clin Cancer Res. , vol.23 , pp. 2972-2980
    • D'Angelo, S.P.1    Shoushtari, A.N.2    Keohan, M.L.3    Dickson, M.A.4    Gounder, M.M.5    Chi, P.6    Loo, J.K.7    Gaffney, L.8    Schneider, L.9    Patel, Z.10
  • 188
    • 84973390002 scopus 로고    scopus 로고
    • Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer
    • 27393510,. https://doi.org/,. PMID
    • Boyer MJ, Gu L, Wang X, Kelsey CR, Yoo DS, Onaitis MW, Dunphy FR, Crawford J, Ready NE, Salama JK. Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer. Lung Cancer. 2016; 98:76-8. https://doi.org/10.1016/j.lungcan.2016.05.014. PMID:27393510
    • (2016) Lung Cancer. , vol.98 , pp. 76-78
    • Boyer, M.J.1    Gu, L.2    Wang, X.3    Kelsey, C.R.4    Yoo, D.S.5    Onaitis, M.W.6    Dunphy, F.R.7    Crawford, J.8    Ready, N.E.9    Salama, J.K.10
  • 189
    • 84987849612 scopus 로고    scopus 로고
    • Outcome and biomarker analysis from a multicenter phase 2 study of ipilimumab in combination with carboplatin and etoposide as first-line therapy for extensive-stage SCLC
    • 27296105, et al.,. https://doi.org/,. PMID
    • Arriola E, Wheater M, Galea I, Cross N, Maishman T, Hamid D, Stanton L, Cave J, Geldart T, Mulatero C, et al. Outcome and biomarker analysis from a multicenter phase 2 study of ipilimumab in combination with carboplatin and etoposide as first-line therapy for extensive-stage SCLC. J Thorac Oncol. 2016; 11:1511-21. https://doi.org/10.1016/j.jtho.2016.05.028. PMID:27296105
    • (2016) J Thorac Oncol. , vol.11 , pp. 1511-1521
    • Arriola, E.1    Wheater, M.2    Galea, I.3    Cross, N.4    Maishman, T.5    Hamid, D.6    Stanton, L.7    Cave, J.8    Geldart, T.9    Mulatero, C.10
  • 190
    • 85007425840 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): Results of an open-label, phase 1, multicohort study
    • 27932067, et al.,. https://doi.org/,. PMID
    • Hellmann MD, Rizvi NA, Goldman JW, Gettinger SN, Borghaei H, Brahmer JR, Ready NE, Gerber DE, Chow LQ, Juergens RA, et al. Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): Results of an open-label, phase 1, multicohort study. Lancet Oncol. 2017; 18:31-41. https://doi.org/10.1016/S1470-2045(16)30624-6. PMID:27932067
    • (2017) Lancet Oncol. , vol.18 , pp. 31-41
    • Hellmann, M.D.1    Rizvi, N.A.2    Goldman, J.W.3    Gettinger, S.N.4    Borghaei, H.5    Brahmer, J.R.6    Ready, N.E.7    Gerber, D.E.8    Chow, L.Q.9    Juergens, R.A.10
  • 193
    • 84936749833 scopus 로고    scopus 로고
    • Overall survival and long-term safety of nivolumab (Anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
    • 25897158, et al.,. https://doi.org/,. PMID
    • Gettinger SN, Horn L, Gandhi L, Spigel DR, Antonia SJ, Rizvi NA, Powderly JD, Heist RS, Carvajal RD, Jackman DM, et al. Overall survival and long-term safety of nivolumab (Anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2015; 33:2004-12. https://doi.org/10.1200/JCO.2014.58.3708. PMID:25897158
    • (2015) J Clin Oncol. , vol.33 , pp. 2004-2012
    • Gettinger, S.N.1    Horn, L.2    Gandhi, L.3    Spigel, D.R.4    Antonia, S.J.5    Rizvi, N.A.6    Powderly, J.D.7    Heist, R.S.8    Carvajal, R.D.9    Jackman, D.M.10
  • 194
    • 84983598249 scopus 로고    scopus 로고
    • Nivolumab in combination with platinum-based doublet chemotherapy for first-line treatment of advanced non-small-cell lung cancer
    • 27354481, et al.,. https://doi.org/,. PMID
    • Rizvi NA, Hellmann MD, Brahmer JR, Juergens RA, Borghaei H, Gettinger S, Chow LQ, Gerber DE, Laurie SA, Goldman JW, et al. Nivolumab in combination with platinum-based doublet chemotherapy for first-line treatment of advanced non-small-cell lung cancer. J Clin Oncol. 2016; 34:2969-79. https://doi.org/10.1200/JCO.2016.66.9861. PMID:27354481
    • (2016) J Clin Oncol. , vol.34 , pp. 2969-2979
    • Rizvi, N.A.1    Hellmann, M.D.2    Brahmer, J.R.3    Juergens, R.A.4    Borghaei, H.5    Gettinger, S.6    Chow, L.Q.7    Gerber, D.E.8    Laurie, S.A.9    Goldman, J.W.10
  • 197
    • 85015412706 scopus 로고    scopus 로고
    • Safety and efficacy of nivolumab and standard chemotherapy drug combination in patients with advanced non-small-cell lung cancer: A four arms phase Ib study
    • 27765756, et al.,. https://doi.org/,. PMID
    • Kanda S, Goto K, Shiraishi H, Kubo E, Tanaka A, Utsumi H, Sunami K, Kitazono S, Mizugaki H, Horinouchi H, et al. Safety and efficacy of nivolumab and standard chemotherapy drug combination in patients with advanced non-small-cell lung cancer: A four arms phase Ib study. Ann Oncol. 2016; 27:2242-50. https://doi.org/10.1093/annonc/mdw416. PMID:27765756
    • (2016) Ann Oncol. , vol.27 , pp. 2242-2250
    • Kanda, S.1    Goto, K.2    Shiraishi, H.3    Kubo, E.4    Tanaka, A.5    Utsumi, H.6    Sunami, K.7    Kitazono, S.8    Mizugaki, H.9    Horinouchi, H.10
  • 199
    • 84924901863 scopus 로고    scopus 로고
    • Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
    • 25704439, et al.,. https://doi.org/,. PMID
    • Rizvi NA, Mazieres J, Planchard D, Stinchcombe TE, Dy GK, Antonia SJ, Horn L, Lena H, Minenza E, Mennecier B, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial. Lancet Oncol. 2015; 16:257-65. https://doi.org/10.1016/S1470-2045(15)70054-9. PMID:25704439
    • (2015) Lancet Oncol. , vol.16 , pp. 257-265
    • Rizvi, N.A.1    Mazieres, J.2    Planchard, D.3    Stinchcombe, T.E.4    Dy, G.K.5    Antonia, S.J.6    Horn, L.7    Lena, H.8    Minenza, E.9    Mennecier, B.10
  • 201
    • 85010416862 scopus 로고    scopus 로고
    • Safety and efficacy of nivolumab in patients with metastatic renal cell carcinoma treated beyond progression: A subgroup analysis of a randomized clinical trial
    • 27243803,. https://doi.org/,. PMID
    • George S, Motzer RJ, Hammers HJ, Redman BG, Kuzel TM, Tykodi SS, Plimack ER, Jiang J, Waxman IM, Rini BI. Safety and efficacy of nivolumab in patients with metastatic renal cell carcinoma treated beyond progression: A subgroup analysis of a randomized clinical trial. JAMA Oncol. 2016; 2:1179-86. https://doi.org/10.1001/jamaoncol.2016.0775. PMID:27243803
    • (2016) JAMA Oncol. , vol.2 , pp. 1179-1186
    • George, S.1    Motzer, R.J.2    Hammers, H.J.3    Redman, B.G.4    Kuzel, T.M.5    Tykodi, S.S.6    Plimack, E.R.7    Jiang, J.8    Waxman, I.M.9    Rini, B.I.10
  • 202
    • 84973547996 scopus 로고    scopus 로고
    • Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: A randomised, open-label, phase 3 trial
    • 27283863, et al.,. https://doi.org/,. PMID
    • Cella D, Grunwald V, Nathan P, Doan J, Dastani H, Taylor F, Bennett B, DeRosa M, Berry S, Broglio K, et al. Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: A randomised, open-label, phase 3 trial. Lancet Oncol. 2016; 17:994-1003. https://doi.org/10.1016/S1470-2045(16)30125-5. PMID:27283863
    • (2016) Lancet Oncol. , vol.17 , pp. 994-1003
    • Cella, D.1    Grunwald, V.2    Nathan, P.3    Doan, J.4    Dastani, H.5    Taylor, F.6    Bennett, B.7    DeRosa, M.8    Berry, S.9    Broglio, K.10
  • 204
    • 84929361060 scopus 로고    scopus 로고
    • Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab
    • 25800770, et al.,. https://doi.org/,. PMID
    • McDermott DF, Drake CG, Sznol M, Choueiri TK, Powderly JD, Smith DC, Brahmer JR, Carvajal RD, Hammers HJ, Puzanov I, et al. Survival, durable response, and long-term safety in patients with previously treated advanced renal cell carcinoma receiving nivolumab. J Clin Oncol. 2015; 33:2013-20. https://doi.org/10.1200/JCO.2014.58.1041. PMID:25800770
    • (2015) J Clin Oncol. , vol.33 , pp. 2013-2020
    • McDermott, D.F.1    Drake, C.G.2    Sznol, M.3    Choueiri, T.K.4    Powderly, J.D.5    Smith, D.C.6    Brahmer, J.R.7    Carvajal, R.D.8    Hammers, H.J.9    Puzanov, I.10
  • 206
    • 85014412019 scopus 로고    scopus 로고
    • CheckMate 025 randomized phase 3 study: Outcomes by key baseline factors and prior therapy for nivolumab versus everolimus in advanced renal cell carcinoma
    • 28262413, et al.,. https://doi.org/,. PMID
    • Escudier B, Sharma P, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, et al. CheckMate 025 randomized phase 3 study: Outcomes by key baseline factors and prior therapy for nivolumab versus everolimus in advanced renal cell carcinoma. Eur Urol. 2017. https://doi.org/10.1016/j.eururo.2017.02.010. PMID:28262413
    • (2017) Eur Urol.
    • Escudier, B.1    Sharma, P.2    McDermott, D.F.3    George, S.4    Hammers, H.J.5    Srinivas, S.6    Tykodi, S.S.7    Sosman, J.A.8    Procopio, G.9    Plimack, E.R.10
  • 208
    • 85016509105 scopus 로고    scopus 로고
    • Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab
    • 26873574, et al.,. https://doi.org/,. PMID
    • Weber J, Gibney G, Kudchadkar R, Yu B, Cheng P, Martinez AJ, Kroeger J, Richards A, McCormick L, Moberg V, et al. Phase I/II study of metastatic melanoma patients treated with nivolumab who had progressed after ipilimumab. Cancer Immunol Res. 2016; 4:345-53. https://doi.org/10.1158/2326-6066.CIR-15-0193. PMID:26873574
    • (2016) Cancer Immunol Res. , vol.4 , pp. 345-353
    • Weber, J.1    Gibney, G.2    Kudchadkar, R.3    Yu, B.4    Cheng, P.5    Martinez, A.J.6    Kroeger, J.7    Richards, A.8    McCormick, L.9    Moberg, V.10
  • 210
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
    • 25795410, et al.,. https://doi.org/,. PMID
    • Weber JS, D'Angelo SP, Minor D, Hodi FS, Gutzmer R, Neyns B, Hoeller C, Khushalani NI, Miller WH, Jr, Lao CD, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015; 16:375-84. https://doi.org/10.1016/S1470-2045(15)70076-8. PMID:25795410
    • (2015) Lancet Oncol. , vol.16 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3    Hodi, F.S.4    Gutzmer, R.5    Neyns, B.6    Hoeller, C.7    Khushalani, N.I.8    Miller, W.H.9    Lao, C.D.10
  • 212
    • 85013224907 scopus 로고    scopus 로고
    • Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): A multicentre, single-arm, phase 2 study
    • 28223062, et al.,. https://doi.org/,. PMID
    • Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, et al. Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): A multicentre, single-arm, phase 2 study. Lancet Oncol. 2017; 18:446-53. https://doi.org/10.1016/S1470-2045(17)30104-3. PMID:28223062
    • (2017) Lancet Oncol. , vol.18 , pp. 446-453
    • Morris, V.K.1    Salem, M.E.2    Nimeiri, H.3    Iqbal, S.4    Singh, P.5    Ciombor, K.6    Polite, B.7    Deming, D.8    Chan, E.9    Wade, J.L.10
  • 213
    • 85018660134 scopus 로고    scopus 로고
    • Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial
    • 28434648, et al.,. https://doi.org/,. PMID
    • El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling THR, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 2017; 389:2492-502. https://doi.org/10.1016/S0140-6736(17)31046-2. PMID:28434648
    • (2017) Lancet. , vol.389 , pp. 2492-2502
    • El-Khoueiry, A.B.1    Sangro, B.2    Yau, T.3    Crocenzi, T.S.4    Kudo, M.5    Hsu, C.6    Kim, T.Y.7    Choo, S.P.8    Trojan, J.9    Welling, T.H.R.10
  • 214
  • 215
    • 85018782053 scopus 로고    scopus 로고
    • Nivolumab treatment for oesophageal squamous-cell carcinoma: An open-label, multicentre, phase 2 trial
    • 28314688, et al.,. https://doi.org/,. PMID
    • Kudo T, Hamamoto Y, Kato K, Ura T, Kojima T, Tsushima T, Hironaka S, Hara H, Satoh T, Iwasa S, et al. Nivolumab treatment for oesophageal squamous-cell carcinoma: An open-label, multicentre, phase 2 trial. Lancet Oncol. 2017; 18:631-9. https://doi.org/10.1016/S1470-2045(17)30181-X. PMID:28314688
    • (2017) Lancet Oncol. , vol.18 , pp. 631-639
    • Kudo, T.1    Hamamoto, Y.2    Kato, K.3    Ura, T.4    Kojima, T.5    Tsushima, T.6    Hironaka, S.7    Hara, H.8    Satoh, T.9    Iwasa, S.10
  • 217
    • 84994525384 scopus 로고    scopus 로고
    • Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: A multicentre, multicohort, single-arm phase 2 trial
    • 27451390, et al.,. https://doi.org/,. PMID
    • Younes A, Santoro A, Shipp M, Zinzani PL, Timmerman JM, Ansell S, Armand P, Fanale M, Ratanatharathorn V, Kuruvilla J, et al. Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: A multicentre, multicohort, single-arm phase 2 trial. Lancet Oncol. 2016; 17:1283-94. https://doi.org/10.1016/S1470-2045(16)30167-X. PMID:27451390
    • (2016) Lancet Oncol. , vol.17 , pp. 1283-1294
    • Younes, A.1    Santoro, A.2    Shipp, M.3    Zinzani, P.L.4    Timmerman, J.M.5    Ansell, S.6    Armand, P.7    Fanale, M.8    Ratanatharathorn, V.9    Kuruvilla, J.10
  • 218
    • 85018293668 scopus 로고    scopus 로고
    • Immunotherapy with single agent nivolumab for advanced leiomyosarcoma of the uterus: Results of a phase 2 study
    • 28440953, et al.,. https://doi.org/,. PMID
    • Ben-Ami E, Barysauskas CM, Solomon S, Tahlil K, Malley R, Hohos M, Polson K, Loucks M, Severgnini M, Patel T, et al. Immunotherapy with single agent nivolumab for advanced leiomyosarcoma of the uterus: Results of a phase 2 study. Cancer. 2017; 123:3285–3290. https://doi.org/10.1002/cncr.30738. PMID:28440953
    • (2017) Cancer. , vol.123 , pp. 3285-3290
    • Ben-Ami, E.1    Barysauskas, C.M.2    Solomon, S.3    Tahlil, K.4    Malley, R.5    Hohos, M.6    Polson, K.7    Loucks, M.8    Severgnini, M.9    Patel, T.10
  • 219
    • 84951126341 scopus 로고    scopus 로고
    • Safety and antitumor activity of Anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer
    • 26351349, et al.,. https://doi.org/,. PMID
    • Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, et al. Safety and antitumor activity of Anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer. J Clin Oncol. 2015; 33:4015-22. https://doi.org/10.1200/JCO.2015.62.3397. PMID:26351349
    • (2015) J Clin Oncol. , vol.33 , pp. 4015-4022
    • Hamanishi, J.1    Mandai, M.2    Ikeda, T.3    Minami, M.4    Kawaguchi, A.5    Murayama, T.6    Kanai, M.7    Mori, Y.8    Matsumoto, S.9    Chikuma, S.10
  • 220
    • 84971620553 scopus 로고    scopus 로고
    • Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): A multicentre, open-label, phase 1/2 trial
    • 27269741, et al.,. https://doi.org/,. PMID
    • Antonia SJ, Lopez-Martin JA, Bendell J, Ott PA, Taylor M, Eder JP, Jager D, Pietanza MC, Le DT, de Braud F, et al. Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): A multicentre, open-label, phase 1/2 trial. Lancet Oncol. 2016; 17:883-95. https://doi.org/10.1016/S1470-2045(16)30098-5. PMID:27269741
    • (2016) Lancet Oncol. , vol.17 , pp. 883-895
    • Antonia, S.J.1    Lopez-Martin, J.A.2    Bendell, J.3    Ott, P.A.4    Taylor, M.5    Eder, J.P.6    Jager, D.7    Pietanza, M.C.8    Le, D.T.9    de Braud, F.10
  • 221
    • 84990852158 scopus 로고    scopus 로고
    • Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): A multicentre, open-label, two-stage, multi-arm, phase 1/2 trial
    • 27733243, et al.,. https://doi.org/,. PMID
    • Sharma P, Callahan MK, Bono P, Kim J, Spiliopoulou P, Calvo E, Pillai RN, Ott PA, de Braud F, Morse M, et al. Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): A multicentre, open-label, two-stage, multi-arm, phase 1/2 trial. Lancet Oncol. 2016; 17:1590-8. https://doi.org/10.1016/S1470-2045(16)30496-X. PMID:27733243
    • (2016) Lancet Oncol. , vol.17 , pp. 1590-1598
    • Sharma, P.1    Callahan, M.K.2    Bono, P.3    Kim, J.4    Spiliopoulou, P.5    Calvo, E.6    Pillai, R.N.7    Ott, P.A.8    de Braud, F.9    Morse, M.10
  • 222
    • 85010904121 scopus 로고    scopus 로고
    • Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): A multicentre, single-arm, phase 2 trial
    • 28131785, et al.,. https://doi.org/,. PMID
    • Sharma P, Retz M, Siefker-Radtke A, Baron A, Necchi A, Bedke J, Plimack ER, Vaena D, Grimm MO, Bracarda S, et al. Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): A multicentre, single-arm, phase 2 trial. Lancet Oncol. 2017; 18:312-22. https://doi.org/10.1016/S1470-2045(17)30065-7. PMID:28131785
    • (2017) Lancet Oncol. , vol.18 , pp. 312-322
    • Sharma, P.1    Retz, M.2    Siefker-Radtke, A.3    Baron, A.4    Necchi, A.5    Bedke, J.6    Plimack, E.R.7    Vaena, D.8    Grimm, M.O.9    Bracarda, S.10
  • 223
    • 84994430500 scopus 로고    scopus 로고
    • Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: A randomised, phase 2 cohort of the open-label KEYNOTE-021 study
    • 27745820, et al.,. https://doi.org/,. PMID
    • Langer CJ, Gadgeel SM, Borghaei H, Papadimitrakopoulou VA, Patnaik A, Powell SF, Gentzler RD, Martins RG, Stevenson JP, Jalal SI, et al. Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: A randomised, phase 2 cohort of the open-label KEYNOTE-021 study. Lancet Oncol. 2016; 17:1497-508. https://doi.org/10.1016/S1470-2045(16)30498-3. PMID:27745820
    • (2016) Lancet Oncol. , vol.17 , pp. 1497-1508
    • Langer, C.J.1    Gadgeel, S.M.2    Borghaei, H.3    Papadimitrakopoulou, V.A.4    Patnaik, A.5    Powell, S.F.6    Gentzler, R.D.7    Martins, R.G.8    Stevenson, J.P.9    Jalal, S.I.10
  • 224
    • 85019062002 scopus 로고    scopus 로고
    • Pembrolizumab as first-line therapy for patients with PD-L1-positive advanced non-small cell lung cancer: A phase 1 trial
    • 28168303, et al.,. https://doi.org/,. PMID
    • Hui R, Garon EB, Goldman JW, Leighl NB, Hellmann MD, Patnaik A, Gandhi L, Eder JP, Ahn MJ, Horn L, et al. Pembrolizumab as first-line therapy for patients with PD-L1-positive advanced non-small cell lung cancer: A phase 1 trial. Ann Oncol. 2017; 28:874-81. https://doi.org/10.1093/annonc/mdx008. PMID:28168303
    • (2017) Ann Oncol. , vol.28 , pp. 874-881
    • Hui, R.1    Garon, E.B.2    Goldman, J.W.3    Leighl, N.B.4    Hellmann, M.D.5    Patnaik, A.6    Gandhi, L.7    Eder, J.P.8    Ahn, M.J.9    Horn, L.10
  • 227
    • 84971619894 scopus 로고    scopus 로고
    • Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: Early analysis of a non-randomised, open-label, phase 2 trial
    • 27267608, et al.,. https://doi.org/,. PMID
    • Goldberg SB, Gettinger SN, Mahajan A, Chiang AC, Herbst RS, Sznol M, Tsiouris AJ, Cohen J, Vortmeyer A, Jilaveanu L, et al. Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: Early analysis of a non-randomised, open-label, phase 2 trial. Lancet Oncol. 2016; 17:976-83. https://doi.org/10.1016/S1470-2045(16)30053-5. PMID:27267608
    • (2016) Lancet Oncol. , vol.17 , pp. 976-983
    • Goldberg, S.B.1    Gettinger, S.N.2    Mahajan, A.3    Chiang, A.C.4    Herbst, R.S.5    Sznol, M.6    Tsiouris, A.J.7    Cohen, J.8    Vortmeyer, A.9    Jilaveanu, L.10
  • 228
    • 84995890821 scopus 로고    scopus 로고
    • Programmed death-ligand 1 expression and response to the anti-programmed death 1 antibody pembrolizumab in melanoma
    • 27863197, et al.,. https://doi.org/,. PMID
    • Daud AI, Wolchok JD, Robert C, Hwu WJ, Weber JS, Ribas A, Hodi FS, Joshua AM, Kefford R, Hersey P, et al. Programmed death-ligand 1 expression and response to the anti-programmed death 1 antibody pembrolizumab in melanoma. J Clin Oncol. 2016; 34:4102-9. https://doi.org/10.1200/JCO.2016.67.2477. PMID:27863197
    • (2016) J Clin Oncol. , vol.34 , pp. 4102-4109
    • Daud, A.I.1    Wolchok, J.D.2    Robert, C.3    Hwu, W.J.4    Weber, J.S.5    Ribas, A.6    Hodi, F.S.7    Joshua, A.M.8    Kefford, R.9    Hersey, P.10
  • 229
    • 84968779639 scopus 로고    scopus 로고
    • Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with pembrolizumab
    • 26951310, et al.,. https://doi.org/,. PMID
    • Hodi FS, Hwu WJ, Kefford R, Weber JS, Daud A, Hamid O, Patnaik A, Ribas A, Robert C, Gangadhar TC, et al. Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with pembrolizumab. J Clin Oncol. 2016; 34:1510-7. https://doi.org/10.1200/JCO.2015.64.0391. PMID:26951310
    • (2016) J Clin Oncol. , vol.34 , pp. 1510-1517
    • Hodi, F.S.1    Hwu, W.J.2    Kefford, R.3    Weber, J.S.4    Daud, A.5    Hamid, O.6    Patnaik, A.7    Ribas, A.8    Robert, C.9    Gangadhar, T.C.10
  • 230
    • 84964341647 scopus 로고    scopus 로고
    • Association of pembrolizumab with tumor response and survival among patients with advanced melanoma
    • 27092830, et al.,. https://doi.org/,. PMID
    • Ribas A, Hamid O, Daud A, Hodi FS, Wolchok JD, Kefford R, Joshua AM, Patnaik A, Hwu WJ, Weber JS, et al. Association of pembrolizumab with tumor response and survival among patients with advanced melanoma. JAMA. 2016; 315:1600-9. https://doi.org/10.1001/jama.2016.4059. PMID:27092830
    • (2016) JAMA. , vol.315 , pp. 1600-1609
    • Ribas, A.1    Hamid, O.2    Daud, A.3    Hodi, F.S.4    Wolchok, J.D.5    Kefford, R.6    Joshua, A.M.7    Patnaik, A.8    Hwu, W.J.9    Weber, J.S.10
  • 231
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
    • 26115796, et al.,. https://doi.org/,. PMID
    • Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, Hodi FS, Schachter J, Pavlick AC, Lewis KD, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial. Lancet Oncol. 2015; 16:908-18. https://doi.org/10.1016/S1470-2045(15)00083-2. PMID:26115796
    • (2015) Lancet Oncol. , vol.16 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3    Schadendorf, D.4    Hamid, O.5    Robert, C.6    Hodi, F.S.7    Schachter, J.8    Pavlick, A.C.9    Lewis, K.D.10
  • 232
    • 85009252187 scopus 로고    scopus 로고
    • Safety and activity of pembrolizumab in patients with locally advanced or metastatic urothelial cancer (KEYNOTE-012): A non-randomised, open-label, phase 1b study
    • 28081914,. https://doi.org/,. PMID
    • Plimack ER, Bellmunt J, Gupta S, Berger R, Chow LQ, Juco J, Lunceford J, Saraf S, Perini RF, O'Donnell PH. Safety and activity of pembrolizumab in patients with locally advanced or metastatic urothelial cancer (KEYNOTE-012): A non-randomised, open-label, phase 1b study. Lancet Oncol. 2017; 18:212-20. https://doi.org/10.1016/S1470-2045(17)30007-4. PMID:28081914
    • (2017) Lancet Oncol. , vol.18 , pp. 212-220
    • Plimack, E.R.1    Bellmunt, J.2    Gupta, S.3    Berger, R.4    Chow, L.Q.5    Juco, J.6    Lunceford, J.7    Saraf, S.8    Perini, R.F.9    O'Donnell, P.H.10
  • 233
    • 85021319211 scopus 로고    scopus 로고
    • A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma: Evaluation of safety and clinical and immunologic response
    • 28662677, et al.,. https://doi.org/,. PMID
    • Sundahl N, De Wolf K, Rottey S, Decaestecker K, De Maeseneer D, Meireson A, Goetghebeur E, Fonteyne V, Verbeke S, De Visschere P, et al. A phase I/II trial of fixed-dose stereotactic body radiotherapy with sequential or concurrent pembrolizumab in metastatic urothelial carcinoma: Evaluation of safety and clinical and immunologic response. J Transl Med. 2017; 15:150. https://doi.org/10.1186/s12967-017-1251-3. PMID:28662677
    • (2017) J Transl Med. , vol.15 , pp. 150
    • Sundahl, N.1    De Wolf, K.2    Rottey, S.3    Decaestecker, K.4    De Maeseneer, D.5    Meireson, A.6    Goetghebeur, E.7    Fonteyne, V.8    Verbeke, S.9    De Visschere, P.10
  • 235
    • 85021447305 scopus 로고    scopus 로고
    • A phase Ib study of pembrolizumab plus chemotherapy in patients with advanced cancer (PembroPlus)
    • 28588322,. https://doi.org/,. PMID
    • Weiss GJ, Waypa J, Blaydorn L, Coats J, McGahey K, Sangal A, Niu J, Lynch CA, Farley JH, Khemka V. A phase Ib study of pembrolizumab plus chemotherapy in patients with advanced cancer (PembroPlus). Br J Cancer. 2017; 117:33-40. https://doi.org/10.1038/bjc.2017.145. PMID:28588322
    • (2017) Br J Cancer. , vol.117 , pp. 33-40
    • Weiss, G.J.1    Waypa, J.2    Blaydorn, L.3    Coats, J.4    McGahey, K.5    Sangal, A.6    Niu, J.7    Lynch, C.A.8    Farley, J.H.9    Khemka, V.10
  • 236
    • 85019941130 scopus 로고    scopus 로고
    • Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: A secondary analysis of the KEYNOTE-001 phase 1 trial
    • 28551359,. https://doi.org/,. PMID
    • Shaverdian N, Lisberg AE, Bornazyan K, Veruttipong D, Goldman JW, Formenti SC, Garon EB, Lee P. Previous radiotherapy and the clinical activity and toxicity of pembrolizumab in the treatment of non-small-cell lung cancer: A secondary analysis of the KEYNOTE-001 phase 1 trial. Lancet Oncol. 2017; 18:895-903. https://doi.org/10.1016/S1470-2045(17)30380-7. PMID:28551359
    • (2017) Lancet Oncol. , vol.18 , pp. 895-903
    • Shaverdian, N.1    Lisberg, A.E.2    Bornazyan, K.3    Veruttipong, D.4    Goldman, J.W.5    Formenti, S.C.6    Garon, E.B.7    Lee, P.8
  • 237
    • 84945554100 scopus 로고    scopus 로고
    • Phase I study of pembrolizumab (MK-3475; Anti-PD-1 monoclonal antibody) in patients with advanced solid tumors
    • 25977344, et al.,. https://doi.org/,. PMID
    • Patnaik A, Kang SP, Rasco D, Papadopoulos KP, Elassaiss-Schaap J, Beeram M, Drengler R, Chen C, Smith L, Espino G, et al. Phase I study of pembrolizumab (MK-3475; Anti-PD-1 monoclonal antibody) in patients with advanced solid tumors. Clin Cancer Res. 2015; 21:4286-93. https://doi.org/10.1158/1078-0432.CCR-14-2607. PMID:25977344
    • (2015) Clin Cancer Res. , vol.21 , pp. 4286-4293
    • Patnaik, A.1    Kang, S.P.2    Rasco, D.3    Papadopoulos, K.P.4    Elassaiss-Schaap, J.5    Beeram, M.6    Drengler, R.7    Chen, C.8    Smith, L.9    Espino, G.10
  • 238
    • 85029504106 scopus 로고    scopus 로고
    • Phase Ib study of utomilumab (PF-05082566), a 4-1BB/CD137 agonist, in combination with pembrolizumab (MK-3475) in patients with advanced solid tumors
    • 28634283, et al.,. https://doi.org/,. PMID
    • Tolcher AW, Sznol M, Hu-Lieskovan S, Papadopoulos KP, Patnaik A, Rasco D, Di Gravio D, Huang B, Gambhire D, Chen Y, et al. Phase Ib study of utomilumab (PF-05082566), a 4-1BB/CD137 agonist, in combination with pembrolizumab (MK-3475) in patients with advanced solid tumors. Clin Cancer Res. 2017. https://doi.org/10.1158/1078-0432.CCR-17-1243. PMID:28634283
    • (2017) Clin Cancer Res.
    • Tolcher, A.W.1    Sznol, M.2    Hu-Lieskovan, S.3    Papadopoulos, K.P.4    Patnaik, A.5    Rasco, D.6    Di Gravio, D.7    Huang, B.8    Gambhire, D.9    Chen, Y.10
  • 239
    • 85026837838 scopus 로고    scopus 로고
    • Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal
    • 28453692, et al.,. https://doi.org/,. PMID
    • Ott PA, Piha-Paul SA, Munster P, Pishvaian MJ, van Brummelen EMJ, Cohen RB, Gomez-Roca C, Ejadi S, Stein M, Chan E, et al. Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal. Ann Oncol. 2017; 28:1036-41. https://doi.org/10.1093/annonc/mdx029. PMID:28453692
    • (2017) Ann Oncol. , vol.28 , pp. 1036-1041
    • Ott, P.A.1    Piha-Paul, S.A.2    Munster, P.3    Pishvaian, M.J.4    van Brummelen, E.M.J.5    Cohen, R.B.6    Gomez-Roca, C.7    Ejadi, S.8    Stein, M.9    Chan, E.10
  • 240
    • 84978198904 scopus 로고    scopus 로고
    • Pembrolizumab in patients with advanced triple-negative breast cancer: Phase Ib KEYNOTE-012 study
    • 27138582, et al.,. https://doi.org/,. PMID
    • Nanda R, Chow LQ, Dees EC, Berger R, Gupta S, Geva R, Pusztai L, Pathiraja K, Aktan G, Cheng JD, et al. Pembrolizumab in patients with advanced triple-negative breast cancer: Phase Ib KEYNOTE-012 study. J Clin Oncol. 2016; 34:2460-7. https://doi.org/10.1200/JCO.2015.64.8931. PMID:27138582
    • (2016) J Clin Oncol. , vol.34 , pp. 2460-2467
    • Nanda, R.1    Chow, L.Q.2    Dees, E.C.3    Berger, R.4    Gupta, S.5    Geva, R.6    Pusztai, L.7    Pathiraja, K.8    Aktan, G.9    Cheng, J.D.10
  • 241
    • 85021757660 scopus 로고    scopus 로고
    • Phase II study of the efficacy and safety of pembrolizumab for relapsed/refractory classic Hodgkin lymphoma
    • 28441111, et al.,. https://doi.org/,. PMID
    • Chen R, Zinzani PL, Fanale MA, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, et al. Phase II study of the efficacy and safety of pembrolizumab for relapsed/refractory classic Hodgkin lymphoma. J Clin Oncol. 2017; 35:2125-32. https://doi.org/10.1200/JCO.2016.72.1316. PMID:28441111
    • (2017) J Clin Oncol. , vol.35 , pp. 2125-2132
    • Chen, R.1    Zinzani, P.L.2    Fanale, M.A.3    Armand, P.4    Johnson, N.A.5    Brice, P.6    Radford, J.7    Ribrag, V.8    Molin, D.9    Vassilakopoulos, T.P.10
  • 243
    • 85014866829 scopus 로고    scopus 로고
    • Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma (KEYNOTE-028): Preliminary results from a non-randomised, open-label, phase 1b trial
    • 28291584,. https://doi.org/,. PMID
    • Alley EW, Lopez J, Santoro A, Morosky A, Saraf S, Piperdi B, van Brummelen E. Clinical safety and activity of pembrolizumab in patients with malignant pleural mesothelioma (KEYNOTE-028): Preliminary results from a non-randomised, open-label, phase 1b trial. Lancet Oncol. 2017; 18:623-30. https://doi.org/10.1016/S1470-2045(17)30169-9. PMID:28291584
    • (2017) Lancet Oncol. , vol.18 , pp. 623-630
    • Alley, E.W.1    Lopez, J.2    Santoro, A.3    Morosky, A.4    Saraf, S.5    Piperdi, B.6    van Brummelen, E.7
  • 244
    • 85019091025 scopus 로고    scopus 로고
    • Pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: Results from a single-arm, phase II study
    • 28328302, et al.,. https://doi.org/,. PMID
    • Bauml J, Seiwert TY, Pfister DG, Worden F, Liu SV, Gilbert J, Saba NF, Weiss J, Wirth L, Sukari A, et al. Pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: Results from a single-arm, phase II study. J Clin Oncol. 2017; 35:1542-9. https://doi.org/10.1200/JCO.2016.70.1524. PMID:28328302
    • (2017) J Clin Oncol. , vol.35 , pp. 1542-1549
    • Bauml, J.1    Seiwert, T.Y.2    Pfister, D.G.3    Worden, F.4    Liu, S.V.5    Gilbert, J.6    Saba, N.F.7    Weiss, J.8    Wirth, L.9    Sukari, A.10
  • 245
    • 85028511452 scopus 로고    scopus 로고
    • Phase II trial of atezolizumab as first-line or subsequent therapy for patients with programmed death-ligand 1-selected advanced non-small-cell lung cancer (BIRCH)
    • 28609226, et al.,. https://doi.org
    • Peters S, Gettinger S, Johnson ML, Janne PA, Garassino MC, Christoph D, Toh CK, Rizvi NA, Chaft JE, Carcereny Costa E, et al. Phase II trial of atezolizumab as first-line or subsequent therapy for patients with programmed death-ligand 1-selected advanced non-small-cell lung cancer (BIRCH). J Clin Oncol. 2017; 35:2781-89. https://doi.org/10.101610.1200/JCO.2016.71.9476. doi:28609226
    • (2017) J Clin Oncol. , vol.35 , pp. 2781-2789
    • Peters, S.1    Gettinger, S.2    Johnson, M.L.3    Janne, P.A.4    Garassino, M.C.5    Christoph, D.6    Toh, C.K.7    Rizvi, N.A.8    Chaft, J.E.9    Carcereny Costa, E.10
  • 246
    • 84962038946 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial
    • 26970723, et al.,. https://doi.org/,. PMID
    • Fehrenbacher L, Spira A, Ballinger M, Kowanetz M, Vansteenkiste J, Mazieres J, Park K, Smith D, Artal-Cortes A, Lewanski C, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial. Lancet. 2016; 387:1837-46. https://doi.org/10.1016/S0140-6736(16)00587-0. PMID:26970723
    • (2016) Lancet. , vol.387 , pp. 1837-1846
    • Fehrenbacher, L.1    Spira, A.2    Ballinger, M.3    Kowanetz, M.4    Vansteenkiste, J.5    Mazieres, J.6    Park, K.7    Smith, D.8    Artal-Cortes, A.9    Lewanski, C.10
  • 247
    • 85008239423 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): A phase 3, open-label, multicentre randomised controlled trial
    • 27979383, et al.,. https://doi.org/,. PMID
    • Rittmeyer A, Barlesi F, Waterkamp D, Park K, Ciardiello F, von Pawel J, Gadgeel SM, Hida T, Kowalski DM, Dols MC, et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): A phase 3, open-label, multicentre randomised controlled trial. Lancet. 2017; 389:255-65. https://doi.org/10.1016/S0140-6736(16)32517-X. PMID:27979383
    • (2017) Lancet. , vol.389 , pp. 255-265
    • Rittmeyer, A.1    Barlesi, F.2    Waterkamp, D.3    Park, K.4    Ciardiello, F.5    von Pawel, J.6    Gadgeel, S.M.7    Hida, T.8    Kowalski, D.M.9    Dols, M.C.10
  • 248
    • 84962497081 scopus 로고    scopus 로고
    • Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: Long-term safety, clinical activity, and immune correlates from a phase Ia study
    • 26755520, et al.,. https://doi.org/,. PMID
    • McDermott DF, Sosman JA, Sznol M, Massard C, Gordon MS, Hamid O, Powderly JD, Infante JR, Fasso M, Wang YV, et al. Atezolizumab, an anti-programmed death-ligand 1 antibody, in metastatic renal cell carcinoma: Long-term safety, clinical activity, and immune correlates from a phase Ia study. J Clin Oncol. 2016; 34:833-42. https://doi.org/10.1200/JCO.2015.63.7421. PMID:26755520
    • (2016) J Clin Oncol. , vol.34 , pp. 833-842
    • McDermott, D.F.1    Sosman, J.A.2    Sznol, M.3    Massard, C.4    Gordon, M.S.5    Hamid, O.6    Powderly, J.D.7    Infante, J.R.8    Fasso, M.9    Wang, Y.V.10
  • 249
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
    • 26952546, et al.,. https://doi.org/,. PMID
    • Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, Dawson N, O'Donnell PH, Balmanoukian A, Loriot Y, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial. Lancet. 2016; 387:1909-20. https://doi.org/10.1016/S0140-6736(16)00561-4. PMID:26952546
    • (2016) Lancet. , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    van der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6    Dawson, N.7    O'Donnell, P.H.8    Balmanoukian, A.9    Loriot, Y.10
  • 250
    • 85007564166 scopus 로고    scopus 로고
    • Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: A single-arm, multicentre, phase 2 trial
    • 27939400, et al.,. https://doi.org/,. PMID
    • Balar AV, Galsky MD, Rosenberg JE, Powles T, Petrylak DP, Bellmunt J, Loriot Y, Necchi A, Hoffman-Censits J, Perez-Gracia JL, et al. Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: A single-arm, multicentre, phase 2 trial. Lancet. 2017; 389:67-76. https://doi.org/10.1016/S0140-6736(16)32455-2. PMID:27939400
    • (2017) Lancet. , vol.389 , pp. 67-76
    • Balar, A.V.1    Galsky, M.D.2    Rosenberg, J.E.3    Powles, T.4    Petrylak, D.P.5    Bellmunt, J.6    Loriot, Y.7    Necchi, A.8    Hoffman-Censits, J.9    Perez-Gracia, J.L.10
  • 251
    • 85020609662 scopus 로고    scopus 로고
    • Avelumab, an anti-programmed death-ligand 1 antibody, in patients with refractory metastatic urothelial carcinoma: Results from a multicenter, phase Ib study
    • 28375787, et al.,. https://doi.org/,. PMID
    • Apolo AB, Infante JR, Balmanoukian A, Patel MR, Wang D, Kelly K, Mega AE, Britten CD, Ravaud A, Mita AC, et al. Avelumab, an anti-programmed death-ligand 1 antibody, in patients with refractory metastatic urothelial carcinoma: Results from a multicenter, phase Ib study. J Clin Oncol. 2017; 35:2117-24. https://doi.org/10.1200/JCO.2016.71.6795. PMID:28375787
    • (2017) J Clin Oncol. , vol.35 , pp. 2117-2124
    • Apolo, A.B.1    Infante, J.R.2    Balmanoukian, A.3    Patel, M.R.4    Wang, D.5    Kelly, K.6    Mega, A.E.7    Britten, C.D.8    Ravaud, A.9    Mita, A.C.10
  • 252
    • 85016402243 scopus 로고    scopus 로고
    • Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN solid tumor): A phase 1a, multicohort, dose-escalation trial
    • 28373007, et al.,. https://doi.org/,. PMID
    • Heery CR, O'Sullivan-Coyne G, Madan RA, Cordes L, Rajan A, Rauckhorst M, Lamping E, Oyelakin I, Marte JL, Lepone LM, et al. Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN solid tumor): A phase 1a, multicohort, dose-escalation trial. Lancet Oncol. 2017; 18:587-98. https://doi.org/10.1016/S1470-2045(17)30239-5. PMID:28373007
    • (2017) Lancet Oncol. , vol.18 , pp. 587-598
    • Heery, C.R.1    O'Sullivan-Coyne, G.2    Madan, R.A.3    Cordes, L.4    Rajan, A.5    Rauckhorst, M.6    Lamping, E.7    Oyelakin, I.8    Marte, J.L.9    Lepone, L.M.10
  • 253
    • 84992340907 scopus 로고    scopus 로고
    • Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: A multicentre, single-group, open-label, phase 2 trial
    • 27592805, et al.,. PMID
    • Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbe C, Linette GP, Milella M, et al. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: A multicentre, single-group, open-label, phase 2 trial. Lancet Oncol. 2016; 17:1374-85. PMID:27592805
    • (2016) Lancet Oncol. , vol.17 , pp. 1374-1385
    • Kaufman, H.L.1    Russell, J.2    Hamid, O.3    Bhatia, S.4    Terheyden, P.5    D'Angelo, S.P.6    Shih, K.C.7    Lebbe, C.8    Linette, G.P.9    Milella, M.10
  • 254
    • 85016412723 scopus 로고    scopus 로고
    • Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN solid tumor): Dose-expansion cohort of a multicentre, open-label, phase 1b trial
    • 28373005, et al.,. PMID
    • Gulley JL, Rajan A, Spigel DR, Iannotti N, Chandler J, Wong DJL, Leach J, Edenfield WJ, Wang D, Grote HJ, et al. Avelumab for patients with previously treated metastatic or recurrent non-small-cell lung cancer (JAVELIN solid tumor): Dose-expansion cohort of a multicentre, open-label, phase 1b trial. Lancet Oncol. 2017; 18:599-610. PMID:28373005
    • (2017) Lancet Oncol. , vol.18 , pp. 599-610
    • Gulley, J.L.1    Rajan, A.2    Spigel, D.R.3    Iannotti, N.4    Chandler, J.5    Wong, D.J.L.6    Leach, J.7    Edenfield, W.J.8    Wang, D.9    Grote, H.J.10
  • 256
    • 85021746571 scopus 로고    scopus 로고
    • Safety and clinical activity of the programmed death-ligand 1 inhibitor durvalumab in combination with poly (ADP-Ribose) polymerase inhibitor olaparib or vascular endothelial growth factor receptor 1–3 inhibitor cediranib in women's cancers: A dose-escalation, phase I study
    • 28471727, et al.,. PMID
    • Lee JM, Cimino-Mathews A, Peer CJ, Zimmer A, Lipkowitz S, Annunziata CM, Cao L, Harrell MI, Swisher EM, Houston N, et al. Safety and clinical activity of the programmed death-ligand 1 inhibitor durvalumab in combination with poly (ADP-Ribose) polymerase inhibitor olaparib or vascular endothelial growth factor receptor 1–3 inhibitor cediranib in women's cancers: A dose-escalation, phase I study. J Clin Oncol. 2017; 35:2193-202. PMID:28471727
    • (2017) J Clin Oncol. , vol.35 , pp. 2193-2202
    • Lee, J.M.1    Cimino-Mathews, A.2    Peer, C.J.3    Zimmer, A.4    Lipkowitz, S.5    Annunziata, C.M.6    Cao, L.7    Harrell, M.I.8    Swisher, E.M.9    Houston, N.10
  • 257
    • 84989918072 scopus 로고    scopus 로고
    • Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer
    • 27269937, et al.,. PMID
    • Massard C, Gordon MS, Sharma S, Rafii S, Wainberg ZA, Luke J, Curiel TJ, Colon-Otero G, Hamid O, Sanborn RE, et al. Safety and efficacy of durvalumab (MEDI4736), an anti-programmed cell death ligand-1 immune checkpoint inhibitor, in patients with advanced urothelial bladder cancer. J Clin Oncol. 2016; 34:3119-25. PMID:27269937
    • (2016) J Clin Oncol. , vol.34 , pp. 3119-3125
    • Massard, C.1    Gordon, M.S.2    Sharma, S.3    Rafii, S.4    Wainberg, Z.A.5    Luke, J.6    Curiel, T.J.7    Colon-Otero, G.8    Hamid, O.9    Sanborn, R.E.10
  • 258
    • 34548240159 scopus 로고    scopus 로고
    • Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer
    • 17673618,. PMID
    • Ribas A, Hanson DC, Noe DA, Millham R, Guyot DJ, Bernstein SH, Canniff PC, Sharma A, Gomez-Navarro J. Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer. Oncologist. 2007; 12:873-83. PMID:17673618
    • (2007) Oncologist. , vol.12 , pp. 873-883
    • Ribas, A.1    Hanson, D.C.2    Noe, D.A.3    Millham, R.4    Guyot, D.J.5    Bernstein, S.H.6    Canniff, P.C.7    Sharma, A.8    Gomez-Navarro, J.9
  • 260
    • 85024501909 scopus 로고    scopus 로고
    • Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): A multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial
    • 28729154, et al.,. https://doi.org/,. PMID
    • Maio M, Scherpereel A, Calabro L, Aerts J, Cedres Perez S, Bearz A, Nackaerts K, Fennell DA, Kowalski D, Tsao AS, et al. Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): A multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial. Lancet Oncol. 2017. https://doi.org/10.1016/S1470-2045(17)30446-1. PMID:28729154
    • (2017) Lancet Oncol.
    • Maio, M.1    Scherpereel, A.2    Calabro, L.3    Aerts, J.4    Cedres Perez, S.5    Bearz, A.6    Nackaerts, K.7    Fennell, D.A.8    Kowalski, D.9    Tsao, A.S.10
  • 261
    • 84976535754 scopus 로고    scopus 로고
    • CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma
    • 27471622,. PMID
    • Yu GT, Bu LL, Zhao YY, Mao L, Deng WW, Wu TF, Zhang WF, Sun ZJ. CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma. Oncoimmunology. 2016; 5:e1151594. PMID:27471622
    • (2016) Oncoimmunology. , vol.5 , pp. e1151594
    • Yu, G.T.1    Bu, L.L.2    Zhao, Y.Y.3    Mao, L.4    Deng, W.W.5    Wu, T.F.6    Zhang, W.F.7    Sun, Z.J.8
  • 262
    • 85014421565 scopus 로고    scopus 로고
    • LAG3 (CD223) as a cancer immunotherapy target
    • 28258692,. https://doi.org/,. PMID
    • Andrews LP, Marciscano AE, Drake CG, Vignali DA. LAG3 (CD223) as a cancer immunotherapy target. Immunol Rev. 2017; 276:80-96. https://doi.org/10.1111/imr.12519. PMID:28258692
    • (2017) Immunol Rev. , vol.276 , pp. 80-96
    • Andrews, L.P.1    Marciscano, A.E.2    Drake, C.G.3    Vignali, D.A.4
  • 263
    • 84944474608 scopus 로고    scopus 로고
    • LAG3 and PD1co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
    • 26318293,. https://doi.org/,. PMID
    • Huang RY, Eppolito C, Lele S, Shrikant P, Matsuzaki J, Odunsi K. LAG3 and PD1co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model. Oncotarget. 2015; 6:27359-77. https://doi.org/10.18632/oncotarget.4751. PMID:26318293
    • (2015) Oncotarget. , vol.6 , pp. 27359-27377
    • Huang, R.Y.1    Eppolito, C.2    Lele, S.3    Shrikant, P.4    Matsuzaki, J.5    Odunsi, K.6
  • 264
    • 84962326872 scopus 로고    scopus 로고
    • Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8T-cell responses in metastatic melanoma patients–report of a phase I/IIa clinical trial
    • 26500235, et al.,. https://doi.org/,. PMID
    • Legat A, Maby-El Hajjami H, Baumgaertner P, Cagnon L, Abed Maillard S, Geldhof C, Iancu EM, Lebon L, Guillaume P, Dojcinovic D, et al. Vaccination with LAG-3Ig (IMP321) and peptides induces specific CD4 and CD8T-cell responses in metastatic melanoma patients–report of a phase I/IIa clinical trial. Clin Cancer Res. 2016; 22:1330-40. https://doi.org/10.1158/1078-0432.CCR-15-1212. PMID:26500235
    • (2016) Clin Cancer Res. , vol.22 , pp. 1330-1340
    • Legat, A.1    Maby-El Hajjami, H.2    Baumgaertner, P.3    Cagnon, L.4    Abed Maillard, S.5    Geldhof, C.6    Iancu, E.M.7    Lebon, L.8    Guillaume, P.9    Dojcinovic, D.10
  • 265
    • 84987623646 scopus 로고    scopus 로고
    • Lymphocyte-activation gene-3, an important immune checkpoint in cancer
    • 27297395,. https://doi.org/,. PMID
    • He Y, Rivard CJ, Rozeboom L, Yu H, Ellison K, Kowalewski A, Zhou C, Hirsch FR. Lymphocyte-activation gene-3, an important immune checkpoint in cancer. Cancer Sci. 2016; 107:1193-7. https://doi.org/10.1111/cas.12986. PMID:27297395
    • (2016) Cancer Sci. , vol.107 , pp. 1193-1197
    • He, Y.1    Rivard, C.J.2    Rozeboom, L.3    Yu, H.4    Ellison, K.5    Kowalewski, A.6    Zhou, C.7    Hirsch, F.R.8
  • 266
    • 35748957791 scopus 로고    scopus 로고
    • A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells
    • 17785860,. https://doi.org/,. PMID
    • Brignone C, Grygar C, Marcu M, Schakel K, Triebel F. A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J Immunol. 2007; 179:4202-11. https://doi.org/10.4049/jimmunol.179.6.4202. PMID:17785860
    • (2007) J Immunol. , vol.179 , pp. 4202-4211
    • Brignone, C.1    Grygar, C.2    Marcu, M.3    Schakel, K.4    Triebel, F.5
  • 267
    • 84869819029 scopus 로고    scopus 로고
    • A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
    • 23033266, et al.,. https://doi.org/,. PMID
    • Benson DM, Jr, Hofmeister CC, Padmanabhan S, Suvannasankha A, Jagannath S, Abonour R, Bakan C, Andre P, Efebera Y, Tiollier J, et al. A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma. Blood. 2012; 120:4324-33. https://doi.org/10.1182/blood-2012-06-438028. PMID:23033266
    • (2012) Blood. , vol.120 , pp. 4324-4333
    • Benson, D.M.1    Hofmeister, C.C.2    Padmanabhan, S.3    Suvannasankha, A.4    Jagannath, S.5    Abonour, R.6    Bakan, C.7    Andre, P.8    Efebera, Y.9    Tiollier, J.10
  • 269
    • 84993965454 scopus 로고    scopus 로고
    • Targeting KIR blockade in multiple myeloma: Trouble in checkpoint paradise?
    • 27430580,. https://doi.org/,. PMID
    • Felices M, Miller JS. Targeting KIR blockade in multiple myeloma: Trouble in checkpoint paradise? Clin Cancer Res. 2016; 22:5161-3. https://doi.org/10.1158/1078-0432.CCR-16-1582. PMID:27430580
    • (2016) Clin Cancer Res. , vol.22 , pp. 5161-5163
    • Felices, M.1    Miller, J.S.2
  • 271
    • 84994592423 scopus 로고    scopus 로고
    • Checkpoint Inhibition of KIR2D with the monoclonal antibody IPH2101 induces contraction and hyporesponsiveness of NK cells in patients with myeloma
    • 27307594,. https://doi.org/,. PMID
    • Carlsten M, Korde N, Kotecha R, Reger R, Bor S, Kazandjian D, Landgren O, Childs RW. Checkpoint Inhibition of KIR2D with the monoclonal antibody IPH2101 induces contraction and hyporesponsiveness of NK cells in patients with myeloma. Clin Cancer Res. 2016; 22:5211-22. https://doi.org/10.1158/1078-0432.CCR-16-1108. PMID:27307594
    • (2016) Clin Cancer Res. , vol.22 , pp. 5211-5222
    • Carlsten, M.1    Korde, N.2    Kotecha, R.3    Reger, R.4    Bor, S.5    Kazandjian, D.6    Landgren, O.7    Childs, R.W.8
  • 272
    • 84979999729 scopus 로고    scopus 로고
    • Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing
    • 27622064,. https://doi.org/,. PMID
    • Kearney CJ, Ramsbottom KM, Voskoboinik I, Darcy PK, Oliaro J. Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing. Oncoimmunology. 2016; 5:e1196308. https://doi.org/10.1080/2162402X.2016.1196308. PMID:27622064
    • (2016) Oncoimmunology. , vol.5 , pp. e1196308
    • Kearney, C.J.1    Ramsbottom, K.M.2    Voskoboinik, I.3    Darcy, P.K.4    Oliaro, J.5
  • 273
    • 84926418972 scopus 로고    scopus 로고
    • Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: An open-label, single-arm, phase 2 study
    • 25819643, et al.,. https://doi.org/,. PMID
    • Calabro L, Morra A, Fonsatti E, Cutaia O, Fazio C, Annesi D, Lenoci M, Amato G, Danielli R, Altomonte M, et al. Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: An open-label, single-arm, phase 2 study. Lancet Respir Med. 2015; 3:301-9. https://doi.org/10.1016/S2213-2600(15)00092-2. PMID:25819643
    • (2015) Lancet Respir Med. , vol.3 , pp. 301-309
    • Calabro, L.1    Morra, A.2    Fonsatti, E.3    Cutaia, O.4    Fazio, C.5    Annesi, D.6    Lenoci, M.7    Amato, G.8    Danielli, R.9    Altomonte, M.10
  • 274
    • 84936937852 scopus 로고    scopus 로고
    • A phase 2 study of tremelimumab in patients with advanced uveal melanoma
    • 26050146,. https://doi.org/,. PMID
    • Joshua AM, Monzon JG, Mihalcioiu C, Hogg D, Smylie M, Cheng T. A phase 2 study of tremelimumab in patients with advanced uveal melanoma. Melanoma Res. 2015; 25:342-7. https://doi.org/10.1097/CMR.0000000000000175. PMID:26050146
    • (2015) Melanoma Res. , vol.25 , pp. 342-347
    • Joshua, A.M.1    Monzon, J.G.2    Mihalcioiu, C.3    Hogg, D.4    Smylie, M.5    Cheng, T.6
  • 275
    • 84927150740 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer therapy
    • 25605845,. https://doi.org/,. PMID
    • Postow MA, Callahan MK, Wolchok JD. Immune checkpoint blockade in cancer therapy. J Clin Oncol. 2015; 33:1974-82. https://doi.org/10.1200/JCO.2014.59.4358. PMID:25605845
    • (2015) J Clin Oncol. , vol.33 , pp. 1974-1982
    • Postow, M.A.1    Callahan, M.K.2    Wolchok, J.D.3
  • 276
    • 84933678156 scopus 로고    scopus 로고
    • Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial
    • 25840693, et al.,. https://doi.org/,. PMID
    • Eggermont AM, Chiarion-Sileni V, Grob JJ, Dummer R, Wolchok JD, Schmidt H, Hamid O, Robert C, Ascierto PA, Richards JM, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial. Lancet Oncol. 2015; 16:522-30. https://doi.org/10.1016/S1470-2045(15)70122-1. PMID:25840693
    • (2015) Lancet Oncol. , vol.16 , pp. 522-530
    • Eggermont, A.M.1    Chiarion-Sileni, V.2    Grob, J.J.3    Dummer, R.4    Wolchok, J.D.5    Schmidt, H.6    Hamid, O.7    Robert, C.8    Ascierto, P.A.9    Richards, J.M.10
  • 277
    • 85017605526 scopus 로고    scopus 로고
    • Efficacy and tolerability of nivolumab after allogeneic transplantation for relapsed Hodgkin lymphoma
    • 28270452, et al.,. https://doi.org/,. PMID
    • Herbaux C, Gauthier J, Brice P, Drumez E, Ysebaert L, Doyen H, Fornecker L, Bouabdallah K, Manson G, Ghesquieres H, et al. Efficacy and tolerability of nivolumab after allogeneic transplantation for relapsed Hodgkin lymphoma. Blood. 2017; 129:2471-8. https://doi.org/10.1182/blood-2016-11-749556. PMID:28270452
    • (2017) Blood. , vol.129 , pp. 2471-2478
    • Herbaux, C.1    Gauthier, J.2    Brice, P.3    Drumez, E.4    Ysebaert, L.5    Doyen, H.6    Fornecker, L.7    Bouabdallah, K.8    Manson, G.9    Ghesquieres, H.10
  • 278
    • 84995489253 scopus 로고    scopus 로고
    • Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results from the phase Ib KEYNOTE-012 expansion cohort
    • 27646946, et al.,. https://doi.org/,. PMID
    • Chow LQ, Haddad R, Gupta S, Mahipal A, Mehra R, Tahara M, Berger R, Eder JP, Burtness B, Lee SH, et al. Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results from the phase Ib KEYNOTE-012 expansion cohort. J Clin Oncol. 2016. https://doi.org/10.1200/JCO.2016.68.1478. PMID:27646946
    • (2016) J Clin Oncol.
    • Chow, L.Q.1    Haddad, R.2    Gupta, S.3    Mahipal, A.4    Mehra, R.5    Tahara, M.6    Berger, R.7    Eder, J.P.8    Burtness, B.9    Lee, S.H.10
  • 279
    • 84969988424 scopus 로고    scopus 로고
    • Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): An open-label, multicentre, phase 1b trial
    • 27247226, et al.,. https://doi.org/,. PMID
    • Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): An open-label, multicentre, phase 1b trial. Lancet Oncol. 2016; 17:956-65. https://doi.org/10.1016/S1470-2045(16)30066-3. PMID:27247226
    • (2016) Lancet Oncol. , vol.17 , pp. 956-965
    • Seiwert, T.Y.1    Burtness, B.2    Mehra, R.3    Weiss, J.4    Berger, R.5    Eder, J.P.6    Heath, K.7    McClanahan, T.8    Lunceford, J.9    Gause, C.10
  • 280
    • 84944460796 scopus 로고    scopus 로고
    • Colorectal cancer: The first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy?
    • 26140250,. https://doi.org/,. PMID
    • Kroemer G, Galluzzi L, Zitvogel L, Fridman WH. Colorectal cancer: The first neoplasia found to be under immunosurveillance and the last one to respond to immunotherapy? Oncoimmunology. 2015; 4:e1058597. https://doi.org/10.1080/2162402X.2015.1058597. PMID:26140250
    • (2015) Oncoimmunology. , vol.4 , pp. e1058597
    • Kroemer, G.1    Galluzzi, L.2    Zitvogel, L.3    Fridman, W.H.4
  • 281
    • 85009701352 scopus 로고    scopus 로고
    • Pembrolizumab (pembro) as first-line therapy for advanced/unresectable or metastatic urothelial cancer: Preliminary results from the phase 2 KEYNOTE-052 study
    • et al.,. https://doi.org
    • Balar A, Bellmunt J, O'Donnell PH, Castellano D, Grivas P, Vuky J, Powles T, Plimack ER, Hahn NM, de Wit R, et al. Pembrolizumab (pembro) as first-line therapy for advanced/unresectable or metastatic urothelial cancer: Preliminary results from the phase 2 KEYNOTE-052 study. Annals of Oncology. 2016; 27:LBA32_PR-LBA_PR. https://doi.org/10.1093/annonc/mdw435.25
    • (2016) Annals of Oncology. , vol.27
    • Balar, A.1    Bellmunt, J.2    O'Donnell, P.H.3    Castellano, D.4    Grivas, P.5    Vuky, J.6    Powles, T.7    Plimack, E.R.8    Hahn, N.M.9    de Wit, R.10
  • 283
    • 84994383071 scopus 로고    scopus 로고
    • Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial
    • 27764686,. https://doi.org/,. PMID
    • Levy A, Massard C, Soria JC, Deutsch E. Concurrent irradiation with the anti-programmed cell death ligand-1 immune checkpoint blocker durvalumab: Single centre subset analysis from a phase 1/2 trial. Eur J Cancer. 2016; 68:156-62. https://doi.org/10.1016/j.ejca.2016.09.013. PMID:27764686
    • (2016) Eur J Cancer. , vol.68 , pp. 156-162
    • Levy, A.1    Massard, C.2    Soria, J.C.3    Deutsch, E.4
  • 284
    • 85027272739 scopus 로고    scopus 로고
    • Abstract A36: CA-170, an oral small molecule PD-L1 and VISTA immune checkpoint antagonist, promotes T cell immune activation and inhibits tumor growth in pre-clinical models of cancer
    • et al.,. https://doi.org
    • Lazorchak AS, Patterson T, Ding Y, Sasikumar PG, Sudarshan NS, Gowda NM, Ramachandra RK, Samiulla DS, Giri S, Eswarappa R, et al. Abstract A36: CA-170, an oral small molecule PD-L1 and VISTA immune checkpoint antagonist, promotes T cell immune activation and inhibits tumor growth in pre-clinical models of cancer. Cancer Immunology Research. 2017; 5:A36-A. https://doi.org/10.1158/2326-6074.TUMIMM16-A36
    • (2017) Cancer Immunology Research. , vol.5 , pp. A36
    • Lazorchak, A.S.1    Patterson, T.2    Ding, Y.3    Sasikumar, P.G.4    Sudarshan, N.S.5    Gowda, N.M.6    Ramachandra, R.K.7    Samiulla, D.S.8    Giri, S.9    Eswarappa, R.10
  • 285
    • 85033411434 scopus 로고    scopus 로고
    • A phase 1 trial of JS001, a monoclonal antibody targeting programmed death-1 (PD-1) in patients with advanced or recurrent malignancies
    • Yang S, Yang J, Han Y, Qin Y, Han X, Dong L, Feng H, Song H, Sun Y, Shi Y. A phase 1 trial of JS001, a monoclonal antibody targeting programmed death-1 (PD-1) in patients with advanced or recurrent malignancies. J Clin Oncol. 2017; 35:e14581
    • (2017) J Clin Oncol. , vol.35 , pp. e14581
    • Yang, S.1    Yang, J.2    Han, Y.3    Qin, Y.4    Han, X.5    Dong, L.6    Feng, H.7    Song, H.8    Sun, Y.9    Shi, Y.10
  • 286
    • 85013653472 scopus 로고    scopus 로고
    • From targeting the tumor to targeting the immune system: Transversal challenges in oncology with the inhibition of the PD-1/PD-L1 axis
    • 28246584,. https://doi.org/,. PMID
    • Bersanelli M, Buti S. From targeting the tumor to targeting the immune system: Transversal challenges in oncology with the inhibition of the PD-1/PD-L1 axis. World J Clin Oncol. 2017; 8:37-53. https://doi.org/10.5306/wjco.v8.i1.37. PMID:28246584
    • (2017) World J Clin Oncol. , vol.8 , pp. 37-53
    • Bersanelli, M.1    Buti, S.2
  • 288
    • 84890096527 scopus 로고    scopus 로고
    • Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: Results of an international phase II trial
    • 24127452, et al.,. https://doi.org/,. PMID
    • Armand P, Nagler A, Weller EA, Devine SM, Avigan DE, Chen YB, Kaminski MS, Holland HK, Winter JN, Mason JR, et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: Results of an international phase II trial. J Clin Oncol. 2013; 31:4199-206. https://doi.org/10.1200/JCO.2012.48.3685. PMID:24127452
    • (2013) J Clin Oncol. , vol.31 , pp. 4199-4206
    • Armand, P.1    Nagler, A.2    Weller, E.A.3    Devine, S.M.4    Avigan, D.E.5    Chen, Y.B.6    Kaminski, M.S.7    Holland, H.K.8    Winter, J.N.9    Mason, J.R.10
  • 289
    • 84905816355 scopus 로고    scopus 로고
    • Pidilizumab in the treatment of diffuse large B-cell lymphoma
    • 25056108,. https://doi.org/,. PMID
    • Bryan LJ, Gordon LI. Pidilizumab in the treatment of diffuse large B-cell lymphoma. Expert Opin Biol Ther. 2014; 14:1361-8. https://doi.org/10.1517/14712598.2014.942637. PMID:25056108
    • (2014) Expert Opin Biol Ther. , vol.14 , pp. 1361-1368
    • Bryan, L.J.1    Gordon, L.I.2
  • 290
    • 84945293157 scopus 로고    scopus 로고
    • Clinical evaluation of compounds targeting PD-1/PD-L1 pathway for cancer immunotherapy
    • 24917416,. https://doi.org/,. PMID
    • Lu J, Lee-Gabel L, Nadeau MC, Ferencz TM, Soefje SA. Clinical evaluation of compounds targeting PD-1/PD-L1 pathway for cancer immunotherapy. J Oncol Pharm Pract. 2015; 21:451-67. https://doi.org/10.1177/1078155214538087. PMID:24917416
    • (2015) J Oncol Pharm Pract. , vol.21 , pp. 451-467
    • Lu, J.1    Lee-Gabel, L.2    Nadeau, M.C.3    Ferencz, T.M.4    Soefje, S.A.5
  • 291
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial
    • 24332512, et al.,. https://doi.org/,. PMID
    • Westin JR, Chu F, Zhang M, Fayad LE, Kwak LW, Fowler N, Romaguera J, Hagemeister F, Fanale M, Samaniego F, et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial. Lancet Oncol. 2014; 15:69-77. https://doi.org/10.1016/S1470-2045(13)70551-5. PMID:24332512
    • (2014) Lancet Oncol. , vol.15 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3    Fayad, L.E.4    Kwak, L.W.5    Fowler, N.6    Romaguera, J.7    Hagemeister, F.8    Fanale, M.9    Samaniego, F.10
  • 292
    • 44949119433 scopus 로고    scopus 로고
    • Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma
    • 18452610, et al.,. https://doi.org/,. PMID
    • Comin-Anduix B, Lee Y, Jalil J, Algazi A, de la Rocha P, Camacho LH, Bozon VA, Bulanhagui CA, Seja E, Villanueva A, et al. Detailed analysis of immunologic effects of the cytotoxic T lymphocyte-associated antigen 4-blocking monoclonal antibody tremelimumab in peripheral blood of patients with melanoma. J Transl Med. 2008; 6:22. https://doi.org/10.1186/1479-5876-6-22. PMID:18452610
    • (2008) J Transl Med. , vol.6 , pp. 22
    • Comin-Anduix, B.1    Lee, Y.2    Jalil, J.3    Algazi, A.4    de la Rocha, P.5    Camacho, L.H.6    Bozon, V.A.7    Bulanhagui, C.A.8    Seja, E.9    Villanueva, A.10
  • 294
    • 77649136167 scopus 로고    scopus 로고
    • Modulation of lymphocyte regulation for cancer therapy: A phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma
    • 20179239,. https://doi.org/,. PMID
    • Ralph C, Elkord E, Burt DJ, O'Dwyer JF, Austin EB, Stern PL, Hawkins RE, Thistlethwaite FC. Modulation of lymphocyte regulation for cancer therapy: A phase II trial of tremelimumab in advanced gastric and esophageal adenocarcinoma. Clin Cancer Res. 2010; 16:1662-72. https://doi.org/10.1158/1078-0432.CCR-09-2870. PMID:20179239
    • (2010) Clin Cancer Res. , vol.16 , pp. 1662-1672
    • Ralph, C.1    Elkord, E.2    Burt, D.J.3    O'Dwyer, J.F.4    Austin, E.B.5    Stern, P.L.6    Hawkins, R.E.7    Thistlethwaite, F.C.8
  • 295
    • 54349094280 scopus 로고    scopus 로고
    • Tremelimumab (CP-675,206): A fully human anticytotoxic T lymphocyte-associated antigen 4 monoclonal antibody for treatment of patients with advanced cancers
    • 18774925,. https://doi.org/,. PMID
    • Tarhini AA, Kirkwood JM. Tremelimumab (CP-675,206): A fully human anticytotoxic T lymphocyte-associated antigen 4 monoclonal antibody for treatment of patients with advanced cancers. Expert Opin Biol Ther. 2008; 8:1583-93. https://doi.org/10.1517/14712598.8.10.1583. PMID:18774925
    • (2008) Expert Opin Biol Ther. , vol.8 , pp. 1583-1593
    • Tarhini, A.A.1    Kirkwood, J.M.2
  • 297
    • 84941343279 scopus 로고    scopus 로고
    • Releasing the Brakes on Cancer Immunotherapy
    • 26359975,. https://doi.org/,. PMID
    • Littman DR. Releasing the Brakes on Cancer Immunotherapy. Cell. 2015; 162:1186-90. https://doi.org/10.1016/j.cell.2015.08.038. PMID:26359975
    • (2015) Cell. , vol.162 , pp. 1186-1190
    • Littman, D.R.1
  • 298
    • 84941344233 scopus 로고    scopus 로고
    • Checkpoints
    • 26359978,. https://doi.org/,. PMID
    • Allison JP. Checkpoints. Cell. 2015; 162:1202-5. https://doi.org/10.1016/j.cell.2015.08.047. PMID:26359978
    • (2015) Cell. , vol.162 , pp. 1202-1205
    • Allison, J.P.1
  • 299
    • 84893965118 scopus 로고    scopus 로고
    • Immune modulation in cancer with antibodies
    • 24188664,. https://doi.org/,. PMID
    • Page DB, Postow MA, Callahan MK, Allison JP, Wolchok JD. Immune modulation in cancer with antibodies. Annu Rev Med. 2014; 65:185-202. https://doi.org/10.1146/annurev-med-092012-112807. PMID:24188664
    • (2014) Annu Rev Med. , vol.65 , pp. 185-202
    • Page, D.B.1    Postow, M.A.2    Callahan, M.K.3    Allison, J.P.4    Wolchok, J.D.5
  • 300
    • 85003945973 scopus 로고    scopus 로고
    • Companion and complementary diagnostics: Clinical and regulatory perspectives
    • 28741518,. https://doi.org/,. PMID
    • Jorgensen JT. Companion and complementary diagnostics: Clinical and regulatory perspectives. Trends Cancer. 2016; 2:706-12. https://doi.org/10.1016/j.trecan.2016.10.013. PMID:28741518
    • (2016) Trends Cancer. , vol.2 , pp. 706-712
    • Jorgensen, J.T.1
  • 301
    • 85029354547 scopus 로고    scopus 로고
    • Monitoring immune-checkpoint blockade: Response evaluation and biomarker development
    • 28653677,. https://doi.org/,. PMID
    • Nishino M, Ramaiya NH, Hatabu H, Hodi FS. Monitoring immune-checkpoint blockade: Response evaluation and biomarker development. Nat Rev Clin Oncol. 2017. https://doi.org/10.1038/nrclinonc.2017.88. PMID:28653677
    • (2017) Nat Rev Clin Oncol.
    • Nishino, M.1    Ramaiya, N.H.2    Hatabu, H.3    Hodi, F.S.4
  • 302
    • 84964310813 scopus 로고    scopus 로고
    • Biomarkers in cancer immunotherapy
    • 25584891,. https://doi.org/,. PMID
    • Schumacher TN, Kesmir C, van Buuren MM. Biomarkers in cancer immunotherapy. Cancer Cell. 2015; 27:12-4. https://doi.org/10.1016/j.ccell.2014.12.004. PMID:25584891
    • (2015) Cancer Cell. , vol.27 , pp. 12-14
    • Schumacher, T.N.1    Kesmir, C.2    van Buuren, M.M.3
  • 303
    • 85030623849 scopus 로고    scopus 로고
    • The immune contexture in cancer prognosis and treatment
    • 28741618,. https://doi.org/,. PMID
    • Fridman WH, Zitvogel L, Sautes-Fridman C, Kroemer G. The immune contexture in cancer prognosis and treatment. Nat Rev Clin Oncol. 2017. https://doi.org/10.1038/nrclinonc.2017.101. PMID:28741618
    • (2017) Nat Rev Clin Oncol.
    • Fridman, W.H.1    Zitvogel, L.2    Sautes-Fridman, C.3    Kroemer, G.4
  • 305
    • 84962840922 scopus 로고    scopus 로고
    • Combination cancer therapies with immune checkpoint blockade: Convergence on interferon signaling
    • 27058661,. https://doi.org/,. PMID
    • Minn AJ, Wherry EJ. Combination cancer therapies with immune checkpoint blockade: Convergence on interferon signaling. Cell. 2016; 165:272-5. https://doi.org/10.1016/j.cell.2016.03.031. PMID:27058661
    • (2016) Cell. , vol.165 , pp. 272-275
    • Minn, A.J.1    Wherry, E.J.2
  • 307
    • 84944463747 scopus 로고    scopus 로고
    • Immunotherapy of hematological cancers: PD-1 blockade for the treatment of Hodgkin's lymphoma
    • 26155425,. https://doi.org/,. PMID
    • Kroemer G, Galluzzi L. Immunotherapy of hematological cancers: PD-1 blockade for the treatment of Hodgkin's lymphoma. Oncoimmunology. 2015; 4:e1008853. https://doi.org/10.1080/2162402X.2015.1008853. PMID:26155425
    • (2015) Oncoimmunology. , vol.4 , pp. e1008853
    • Kroemer, G.1    Galluzzi, L.2
  • 308
    • 84974803082 scopus 로고    scopus 로고
    • Radiotherapy: Changing the game in immunotherapy
    • 27774519,. https://doi.org/,. PMID
    • Demaria S, Coleman CN, Formenti SC. Radiotherapy: Changing the game in immunotherapy. Trends Cancer. 2016; 2:286-94. https://doi.org/10.1016/j.trecan.2016.05.002. PMID:27774519
    • (2016) Trends Cancer. , vol.2 , pp. 286-294
    • Demaria, S.1    Coleman, C.N.2    Formenti, S.C.3
  • 309
    • 84886405297 scopus 로고    scopus 로고
    • Intratumoral anti-CTLA-4 therapy: Enhancing efficacy while avoiding toxicity
    • 23965900,. https://doi.org/,. PMID
    • Marabelle A, Kohrt H, Levy R. Intratumoral anti-CTLA-4 therapy: Enhancing efficacy while avoiding toxicity. Clin Cancer Res. 2013; 19:5261-3. https://doi.org/10.1158/1078-0432.CCR-13-1923. PMID:23965900
    • (2013) Clin Cancer Res. , vol.19 , pp. 5261-5263
    • Marabelle, A.1    Kohrt, H.2    Levy, R.3
  • 310
    • 84886427186 scopus 로고    scopus 로고
    • Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects
    • 23788581,. https://doi.org/,. PMID
    • Fransen MF, van der Sluis TC, Ossendorp F, Arens R, Melief CJ. Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects. Clin Cancer Res. 2013; 19:5381-9. https://doi.org/10.1158/1078-0432.CCR-12-0781. PMID:23788581
    • (2013) Clin Cancer Res. , vol.19 , pp. 5381-5389
    • Fransen, M.F.1    van der Sluis, T.C.2    Ossendorp, F.3    Arens, R.4    Melief, C.J.5
  • 311
    • 85013361181 scopus 로고    scopus 로고
    • Avelumab: Combining immune checkpoint inhibition and antibody-dependent cytotoxicity
    • 28274143,. https://doi.org/,. PMID
    • Hamilton G, Rath B. Avelumab: Combining immune checkpoint inhibition and antibody-dependent cytotoxicity. Expert Opin Biol Ther. 2017; 17:515-23. https://doi.org/10.1080/14712598.2017.1294156. PMID:28274143
    • (2017) Expert Opin Biol Ther. , vol.17 , pp. 515-523
    • Hamilton, G.1    Rath, B.2
  • 312
    • 85019672086 scopus 로고    scopus 로고
    • Novel immune checkpoint blocker to treat Merkel cell carcinoma
    • 28680746,. https://doi.org/,. PMID
    • Galluzzi L, Kroemer G. Novel immune checkpoint blocker to treat Merkel cell carcinoma. Oncoimmunology. 2017; 6:e1315496. https://doi.org/10.1080/2162402X.2017.1315496. PMID:28680746
    • (2017) Oncoimmunology. , vol.6 , pp. e1315496
    • Galluzzi, L.1    Kroemer, G.2
  • 313
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • 25034862, et al.,. https://doi.org/,. PMID
    • Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ, Gangadhar TC, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial. Lancet. 2014; 384:1109-17. https://doi.org/10.1016/S0140-6736(14)60958-2. PMID:25034862
    • (2014) Lancet. , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6    Weber, J.S.7    Joshua, A.M.8    Hwu, W.J.9    Gangadhar, T.C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.