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Volumn 5, Issue 8, 2016, Pages

Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103+ dendritic cells in late-stage ovarian cancer

Author keywords

CD103+; dendritic cells; Lair 1; ovarian cancer; PD 1; T cell exhaustion; tumor microenvironment

Indexed keywords

CD103 ANTIGEN; CD11 ANTIGEN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84979999678     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2016.1185583     Document Type: Article
Times cited : (35)

References (45)
  • 1
    • 84954400636 scopus 로고    scopus 로고
    • Cancer statistics, 2016
    • 26742998
    • R.L.Siegel, K.D.Miller, A.Jemal. Cancer statistics, 2016. CA Cancer J Clin 2016; 66:7-30; PMID:26742998; http://dx.doi.org/10.3322/caac.21349
    • (2016) CA Cancer J Clin , vol.66 , pp. 7-30
    • Siegel, R.L.1    Miller, K.D.2    Jemal, A.3
  • 2
    • 84867525282 scopus 로고    scopus 로고
    • Modulating the tumor immune microenvironment as an ovarian cancer treatment strategy
    • 24039628
    • U.K.Scarlett, J.R.Conejo-Garcia. Modulating the tumor immune microenvironment as an ovarian cancer treatment strategy. Expert Rev Obstet Gynecol 2012; 7:413-9; PMID:24039628; http://dx.doi.org/10.1586/eog.12.41
    • (2012) Expert Rev Obstet Gynecol , vol.7 , pp. 413-419
    • Scarlett, U.K.1    Conejo-Garcia, J.R.2
  • 3
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • 22437870
    • D.M.Pardoll. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-64; PMID:22437870; http://dx.doi.org/10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 4
    • 77950189167 scopus 로고    scopus 로고
    • Ovarian cancer creates a suppressive microenvironment to escape immune elimination
    • 20144842
    • R.Yigit, L.F.Massuger, C.G.Figdor, R.Torensma. Ovarian cancer creates a suppressive microenvironment to escape immune elimination. Gynecol Oncol 2010; 117:366-72; PMID:20144842; http://dx.doi.org/10.1016/j.ygyno.2010.01.019
    • (2010) Gynecol Oncol , vol.117 , pp. 366-372
    • Yigit, R.1    Massuger, L.F.2    Figdor, C.G.3    Torensma, R.4
  • 6
    • 41149148789 scopus 로고    scopus 로고
    • The impact of T-cell immunity on ovarian cancer outcomes
    • 18363996
    • B.H.Nelson. The impact of T-cell immunity on ovarian cancer outcomes. Immunol Rev 2008; 222:101-16; PMID:18363996; http://dx.doi.org/10.1111/j.1600-065X.2008.00614.x
    • (2008) Immunol Rev , vol.222 , pp. 101-116
    • Nelson, B.H.1
  • 7
    • 0037388367 scopus 로고    scopus 로고
    • TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients
    • 12684428
    • K.Schlienger, C.S.Chu, E.Y.Woo, P.M.Rivers, A.J.Toll, B.Hudson, M.V.Maus, J.L.Riley, Y.Choi, G.Coukos et al. TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients. Clin Cancer Res 2003; 9:1517-27; PMID:12684428
    • (2003) Clin Cancer Res , vol.9 , pp. 1517-1527
    • Schlienger, K.1    Chu, C.S.2    Woo, E.Y.3    Rivers, P.M.4    Toll, A.J.5    Hudson, B.6    Maus, M.V.7    Riley, J.L.8    Choi, Y.9    Coukos, G.10
  • 10
    • 84890284474 scopus 로고    scopus 로고
    • Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer
    • 23975756
    • J.Duraiswamy, G.J.Freeman, G.Coukos. Therapeutic PD-1 pathway blockade augments with other modalities of immunotherapy T-cell function to prevent immune decline in ovarian cancer. Cancer Res 2013; 73:6900-12; PMID:23975756; http://dx.doi.org/10.1158/0008-5472.CAN-13-1550
    • (2013) Cancer Res , vol.73 , pp. 6900-6912
    • Duraiswamy, J.1    Freeman, G.J.2    Coukos, G.3
  • 11
    • 79959549102 scopus 로고    scopus 로고
    • Tumor-infiltrating programmed death receptor-1+ dendritic cells mediate immune suppression in ovarian cancer
    • 21551365
    • J.Krempski, L.Karyampudi, M.D.Behrens, C.L.Erskine, L.Hartmann, H.Dong, E.L.Goode, K.R.Kalli, K.L.Knutson. Tumor-infiltrating programmed death receptor-1+ dendritic cells mediate immune suppression in ovarian cancer. J Immunol 2011; 186:6905-13; PMID:21551365; http://dx.doi.org/10.4049/jimmunol.1100274
    • (2011) J Immunol , vol.186 , pp. 6905-6913
    • Krempski, J.1    Karyampudi, L.2    Behrens, M.D.3    Erskine, C.L.4    Hartmann, L.5    Dong, H.6    Goode, E.L.7    Kalli, K.R.8    Knutson, K.L.9
  • 14
    • 77953409587 scopus 로고    scopus 로고
    • Ovarian tumor-induced T cell suppression is alleviated by vascular leukocyte depletion
    • 19956391
    • S.Peter, G.Bak, K.Hart, B.Berwin. Ovarian tumor-induced T cell suppression is alleviated by vascular leukocyte depletion. Transl Oncol 2009; 2:291-9; PMID:19956391; http://dx.doi.org/10.1593/tlo.09190
    • (2009) Transl Oncol , vol.2 , pp. 291-299
    • Peter, S.1    Bak, G.2    Hart, K.3    Berwin, B.4
  • 18
    • 84912089439 scopus 로고    scopus 로고
    • Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells
    • 25446896
    • B.Ruffell, D.Chang-Strachan, V.Chan, A.Rosenbusch, C.M.Ho, N.Pryer, D.Daniel, E.S.Hwang, H.S.Rugo, L.M.Coussens. Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Cancer Cell 2014; 26:623-37; PMID:25446896; http://dx.doi.org/10.1016/j.ccell.2014.09.006
    • (2014) Cancer Cell , vol.26 , pp. 623-637
    • Ruffell, B.1    Chang-Strachan, D.2    Chan, V.3    Rosenbusch, A.4    Ho, C.M.5    Pryer, N.6    Daniel, D.7    Hwang, E.S.8    Rugo, H.S.9    Coussens, L.M.10
  • 19
    • 84908237777 scopus 로고    scopus 로고
    • Aligning bona fide dendritic cell populations across species
    • 25262488
    • C.A.Dutertre, L.F.Wang, F.Ginhoux. Aligning bona fide dendritic cell populations across species. Cell Immunol 2014; 291:3-10; PMID:25262488; http://dx.doi.org/10.1016/j.cellimm.2014.08.006
    • (2014) Cell Immunol , vol.291 , pp. 3-10
    • Dutertre, C.A.1    Wang, L.F.2    Ginhoux, F.3
  • 20
    • 84913555812 scopus 로고    scopus 로고
    • Defining dendritic cells
    • 25553392
    • B.U.Schraml, C.Reis e Sousa. Defining dendritic cells. Curr Opin Immunol 2015; 32:13-20; PMID:25553392; http://dx.doi.org/10.1016/j.coi.2014.11.001
    • (2015) Curr Opin Immunol , vol.32 , pp. 13-20
    • Schraml, B.U.1    Reis e Sousa, C.2
  • 21
    • 77953522371 scopus 로고    scopus 로고
    • Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells
    • 20479115
    • A.Bachem, S.Güttler, E.Hartung, F.Ebstein, M.Schaefer, A.Tannert, A.Salama, K.Movassaghi, C.Opitz, H.W.Mages et al. Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells. J Exp Med 2010; 207:1273-81; PMID:20479115; http://dx.doi.org/10.1084/jem.20100348
    • (2010) J Exp Med , vol.207 , pp. 1273-1281
    • Bachem, A.1    Güttler, S.2    Hartung, E.3    Ebstein, F.4    Schaefer, M.5    Tannert, A.6    Salama, A.7    Movassaghi, K.8    Opitz, C.9    Mages, H.W.10
  • 22
    • 84864332935 scopus 로고    scopus 로고
    • Cross-presentation by dendritic cells
    • 22790179
    • O.P.Joffre, E.Segura, A.Savina, S.Amigorena. Cross-presentation by dendritic cells. Nat Rev Immunol 2012; 12:557-69; PMID:22790179; http://dx.doi.org/10.1038/nri3254
    • (2012) Nat Rev Immunol , vol.12 , pp. 557-569
    • Joffre, O.P.1    Segura, E.2    Savina, A.3    Amigorena, S.4
  • 23
    • 84921530355 scopus 로고    scopus 로고
    • Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1
    • 25520399
    • E.Hartung, M.Becker, A.Bachem, N.Reeg, A.Jäkel, A.Hutloff, H.Weber, C.Weise, C.Giesecke, V.Henn et al. Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1. J Immunol 2015; 194:1069-79; PMID:25520399; http://dx.doi.org/10.4049/jimmunol.1401903
    • (2015) J Immunol , vol.194 , pp. 1069-1079
    • Hartung, E.1    Becker, M.2    Bachem, A.3    Reeg, N.4    Jäkel, A.5    Hutloff, A.6    Weber, H.7    Weise, C.8    Giesecke, C.9    Henn, V.10
  • 25
    • 0037444396 scopus 로고    scopus 로고
    • Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer
    • 12649204
    • D.C.Connolly, R.Bao, A.Y.Nikitin, K.C.Stephens, T.W.Poole, X.Hua, S.S.Harris, B.C.Vanderhyden, T.C.Hamilton. Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer. Cancer Res 2003; 63:1389-97; PMID:12649204
    • (2003) Cancer Res , vol.63 , pp. 1389-1397
    • Connolly, D.C.1    Bao, R.2    Nikitin, A.Y.3    Stephens, K.C.4    Poole, T.W.5    Hua, X.6    Harris, S.S.7    Vanderhyden, B.C.8    Hamilton, T.C.9
  • 26
    • 0030761022 scopus 로고    scopus 로고
    • LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes
    • 9285412
    • L.Meyaard, G.J.Adema, C.Chang, E.Woollatt, G.R.Sutherland, L.L.Lanier, J.H.Phillips. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 1997; 7:283-90; PMID:9285412; http://dx.doi.org/10.1016/S1074-7613(00)80530-0
    • (1997) Immunity , vol.7 , pp. 283-290
    • Meyaard, L.1    Adema, G.J.2    Chang, C.3    Woollatt, E.4    Sutherland, G.R.5    Lanier, L.L.6    Phillips, J.H.7
  • 27
    • 44449101289 scopus 로고    scopus 로고
    • The inhibitory collagen receptor LAIR-1 (CD305)
    • 18063695
    • L.Meyaard. The inhibitory collagen receptor LAIR-1 (CD305). J Leukoc Biol 2008; 83:799-803; PMID:18063695
    • (2008) J Leukoc Biol , vol.83 , pp. 799-803
    • Meyaard, L.1
  • 28
    • 84869210227 scopus 로고    scopus 로고
    • C1q limits dendritic cell differentiation and activation by engaging LAIR-1
    • 23093673
    • M.Son, F.Santiago-Schwarz, Y.Al-Abed, B.Diamond. C1q limits dendritic cell differentiation and activation by engaging LAIR-1. Proc Natl Acad Sci U S A 2012; 109:E3160-7; PMID:23093673; http://dx.doi.org/10.1073/pnas.1212753109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E3160-E3167
    • Son, M.1    Santiago-Schwarz, F.2    Al-Abed, Y.3    Diamond, B.4
  • 29
    • 84922348601 scopus 로고    scopus 로고
    • C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1)
    • 25247291
    • M.Son, B.Diamond. C1q-mediated repression of human monocytes is regulated by leukocyte-associated Ig-like receptor 1 (LAIR-1). Mol Med 2014; 20:559-68; PMID:25247291; http://dx.doi.org/10.2119/molmed.2014.00185
    • (2014) Mol Med , vol.20 , pp. 559-568
    • Son, M.1    Diamond, B.2
  • 31
    • 84931567489 scopus 로고    scopus 로고
    • BDCA3(+)CLEC9A(+) human dendritic cell function and development
    • 24910448
    • E.van der Aa, N.van Montfoort, A.M.Woltman. BDCA3(+)CLEC9A(+) human dendritic cell function and development. Semin Cell Dev Biol 2015; 41:39-48; PMID:24910448; http://dx.doi.org/10.1016/j.semcdb.2014.05.016
    • (2015) Semin Cell Dev Biol , vol.41 , pp. 39-48
    • van der Aa, E.1    van Montfoort, N.2    Woltman, A.M.3
  • 32
    • 80051673918 scopus 로고    scopus 로고
    • Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer
    • 21697280
    • S.I.Labidi-Galy, V.Sisirak, P.Meeus, M.Gobert, A.B.Treilleux, J.-D.Combes, J.Faget, F.Mithieux, A.Cassignol, O.Tredan et al. Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer. Cancer Res 2011; 17:5423-34; PMID:21697280; http://dx.doi.org/10.1158/0008-5472.CAN-11-0367
    • (2011) Cancer Res , vol.17 , pp. 5423-5434
    • Labidi-Galy, S.I.1    Sisirak, V.2    Meeus, P.3    Gobert, M.4    Treilleux, A.B.5    Combes, J.-D.6    Faget, J.7    Mithieux, F.8    Cassignol, A.9    Tredan, O.10
  • 34
    • 33645863160 scopus 로고    scopus 로고
    • The PD-1-PD-L pathway in immunological tolerance
    • 16500147
    • T.Okazaki, T.Honjo. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol 2006; 27:195-201; PMID:16500147; http://dx.doi.org/10.1016/j.it.2006.02.001
    • (2006) Trends Immunol , vol.27 , pp. 195-201
    • Okazaki, T.1    Honjo, T.2
  • 35
    • 84925545111 scopus 로고    scopus 로고
    • Clinical blockade of PD1 and LAG3–potential mechanisms of action
    • 25534622
    • L.T.Nguyen, P.S.Ohashi. Clinical blockade of PD1 and LAG3–potential mechanisms of action. Nat Rev Immunol 2015; 15:45-56; PMID:25534622; http://dx.doi.org/10.1038/nri3790
    • (2015) Nat Rev Immunol , vol.15 , pp. 45-56
    • Nguyen, L.T.1    Ohashi, P.S.2
  • 36
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • 21739672
    • E.J.Wherry. T cell exhaustion. Nat Immunol 2011; 12:492-9; PMID:21739672
    • (2011) Nat Immunol , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 37
    • 84926528302 scopus 로고    scopus 로고
    • Overcoming T cell exhaustion in infection and cancer
    • 25797516
    • K.E.Pauken, E.J.Wherry. Overcoming T cell exhaustion in infection and cancer. Trends Immunol 2015; 36:265-76; PMID:25797516; http://dx.doi.org/10.1016/j.it.2015.02.008
    • (2015) Trends Immunol , vol.36 , pp. 265-276
    • Pauken, K.E.1    Wherry, E.J.2
  • 38
    • 79952281752 scopus 로고    scopus 로고
    • Tumor immune surveillance and ovarian cancer: lessons on immune mediated tumor rejection or tolerance
    • 21298574
    • L.E.Kandalaft, G.T.Motz, J.Duraiswamy, G.Coukos. Tumor immune surveillance and ovarian cancer:lessons on immune mediated tumor rejection or tolerance. Cancer Metastasis Rev 2011; 30:141-51; PMID:21298574; http://dx.doi.org/10.1007/s10555-011-9289-9
    • (2011) Cancer Metastasis Rev , vol.30 , pp. 141-151
    • Kandalaft, L.E.1    Motz, G.T.2    Duraiswamy, J.3    Coukos, G.4
  • 39
    • 68049118835 scopus 로고    scopus 로고
    • CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion
    • 19602595
    • Y.Nesbeth, U.Scarlett, J.Cubillos-Ruiz, D.Martinez, X.Engle, M.J.Turk, J.R.Conejo-Garcia. CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. Cancer Res 2009; 69:6331-8; PMID:19602595; http://dx.doi.org/10.1158/0008-5472.CAN-08-4329
    • (2009) Cancer Res , vol.69 , pp. 6331-6338
    • Nesbeth, Y.1    Scarlett, U.2    Cubillos-Ruiz, J.3    Martinez, D.4    Engle, X.5    Turk, M.J.6    Conejo-Garcia, J.R.7
  • 40
    • 70349750194 scopus 로고    scopus 로고
    • In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells
    • 19738057
    • U.K.Scarlett, J.R.Cubillos-Ruiz, Y.C.Nesbeth, D.G.Martinez, X.Engle, A.T.Gewirtz, C.L.Ahonen, J.R.Conejo-Garcia. In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res 2009; 69:7329-37; PMID:19738057; http://dx.doi.org/10.1158/0008-5472.CAN-09-0835
    • (2009) Cancer Res , vol.69 , pp. 7329-7337
    • Scarlett, U.K.1    Cubillos-Ruiz, J.R.2    Nesbeth, Y.C.3    Martinez, D.G.4    Engle, X.5    Gewirtz, A.T.6    Ahonen, C.L.7    Conejo-Garcia, J.R.8
  • 41
    • 68849112640 scopus 로고    scopus 로고
    • Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity
    • 19620771
    • J.R.Cubillos-Ruiz, X.Engle, U.K.Scarlett, D.Martinez, A.Barber, R.Elgueta, L.Wang, Y.Nesbeth, Y.Durant, A.T.Gewirtz et al. Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest 2009; 119:2231-44; PMID:19620771; http://dx.doi.org/10.1172/JCI37716
    • (2009) J Clin Invest , vol.119 , pp. 2231-2244
    • Cubillos-Ruiz, J.R.1    Engle, X.2    Scarlett, U.K.3    Martinez, D.4    Barber, A.5    Elgueta, R.6    Wang, L.7    Nesbeth, Y.8    Durant, Y.9    Gewirtz, A.T.10
  • 42
    • 84955300805 scopus 로고    scopus 로고
    • CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer
    • 26138335
    • T.Higuchi, D.B.Flies, N.A.Marjon, G.Mantia-Smaldone, L.Ronner, P.A.Gimotty, S.F.Adams. CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer. Cancer Immunol Res 2015; 3:1257-68; PMID:26138335; http://dx.doi.org/10.1158/2326-6066.CIR-15-0044
    • (2015) Cancer Immunol Res , vol.3 , pp. 1257-1268
    • Higuchi, T.1    Flies, D.B.2    Marjon, N.A.3    Mantia-Smaldone, G.4    Ronner, L.5    Gimotty, P.A.6    Adams, S.F.7
  • 43
    • 84936846381 scopus 로고    scopus 로고
    • The emerging role of resident memory T cells in protective immunity and inflammatory disease
    • 26121195
    • C.O.Park, T.S.Kupper. The emerging role of resident memory T cells in protective immunity and inflammatory disease. Nat Med 2015; 21:688-97; PMID:26121195; http://dx.doi.org/10.1038/nm.3883
    • (2015) Nat Med , vol.21 , pp. 688-697
    • Park, C.O.1    Kupper, T.S.2
  • 44
    • 0038446044 scopus 로고    scopus 로고
    • In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice
    • 12847236
    • K.Staveley-O'Carroll, T.D.Schell, M.Jimenez, L.M.Mylin, M.J.Tevethia, S.P.Schoenberger, S.S.Tevethia. In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice. J Immunol 2003; 171:697-707; PMID:12847236; http://dx.doi.org/10.4049/jimmunol.171.2.697
    • (2003) J Immunol , vol.171 , pp. 697-707
    • Staveley-O'Carroll, K.1    Schell, T.D.2    Jimenez, M.3    Mylin, L.M.4    Tevethia, M.J.5    Schoenberger, S.P.6    Tevethia, S.S.7
  • 45
    • 80051930238 scopus 로고    scopus 로고
    • Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models
    • D.B.Flies, S.Wang, H.Xu, L.Chen. Cutting edge:A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models. J Immunol (Baltimore, Md:1950) 2011; 187:1537-41; http://dx.doi.org/10.4049/jimmunol.1100660
    • (2011) J Immunol (Baltimore, Md: 1950) , vol.187 , pp. 1537-1541
    • Flies, D.B.1    Wang, S.2    Xu, H.3    Chen, L.4


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