LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

Oncotarget

Volumn 6, Issue 29, 2015, Pages 27359-27377

  Huang, Ruea Yea ^a   Eppolito, Cheryl ^a   Lele, Shashikant ^a   Shrikant, Protul ^b   Matsuzaki, Junko ^a   Odunsi, Kunle ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Antibody blockade; LAG3; Ovarian cancer; PD1; T cell signaling

Indexed keywords

LYMPHOCYTE RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN LAG3; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG; ANTIBODY; CD223 ANTIGEN; LEUKOCYTE ANTIGEN; PDCD1 PROTEIN, HUMAN; PDCD1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER MODEL; CD8+ T LYMPHOCYTE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EFFECTOR CELL; ENDOSOME; IN VITRO STUDY; INTRACELLULAR SIGNALING; KNOCKOUT MOUSE; LYMPHOCYTE FUNCTION; LYSOSOME; MICROTUBULE ORGANIZING CENTER; MOUSE; MURINE MODEL; MUTATIONAL ANALYSIS; NONHUMAN; OVARY CANCER; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TRANS GOLGI NETWORK; TUMOR IMMUNITY; ANIMAL; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DNA MUTATIONAL ANALYSIS; FEMALE; IMMUNOPRECIPITATION; METABOLISM; MICROTUBULE; OVARY TUMOR; PHENOTYPE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBODIES; ANTIGENS, CD; CD8-POSITIVE T-LYMPHOCYTES; CYTOPLASM; DNA MUTATIONAL ANALYSIS; ENDOSOMES; FEMALE; IMMUNOPRECIPITATION; LYSOSOMES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROTUBULE-ORGANIZING CENTER; MICROTUBULES; OVARIAN NEOPLASMS; PHENOTYPE; PROGRAMMED CELL DEATH 1 RECEPTOR; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 84944474608     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4751     Document Type: Article

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