메뉴 건너뛰기




Volumn 5, Issue 4, 2016, Pages

Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma

Author keywords

B cells; biomarkers; immunotherapy; pancreatic adenocarcinoma (PDAC); tertiary lymphoid tissue

Indexed keywords

ALPHA ENOLASE; CD20 ANTIBODY; CD8 ANTIGEN;

EID: 84962903666     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.1080/2162402X.2015.1085147     Document Type: Article
Times cited : (167)

References (52)
  • 1
    • 84892805731 scopus 로고    scopus 로고
    • Cancer statistics, 2014
    • PMID:24399786
    • R.Siegel, J.Ma, Z.Zou, A.Jemal. Cancer statistics, 2014. CA Cancer J Clin 2014; 64:9-29; PMID:24399786; http://dx.doi.org/10.3322/caac.21208
    • (2014) CA Cancer J Clin , vol.64 , pp. 9-29
    • Siegel, R.1    Ma, J.2    Zou, Z.3    Jemal, A.4
  • 3
    • 35148814410 scopus 로고    scopus 로고
    • Dynamics of the immune reaction to pancreatic cancer from inception to invasion
    • PMID:17909062
    • C.E.Clark, S.R.Hingorani, R.Mick, C.Combs, D.A.Tuveson, R.H.Vonderheide. Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res 2007; 67:9518–27; PMID:17909062; http://dx.doi.org/10.1158/0008-5472.CAN-07-0175
    • (2007) Cancer Res , vol.67 , pp. 9518-9527
    • Clark, C.E.1    Hingorani, S.R.2    Mick, R.3    Combs, C.4    Tuveson, D.A.5    Vonderheide, R.H.6
  • 4
    • 84877052290 scopus 로고    scopus 로고
    • Inflammatory networks and immune surveillance of pancreatic carcinoma
    • PMID:23422836;
    • R.H.Vonderheide, L.J.Bayne. Inflammatory networks and immune surveillance of pancreatic carcinoma. Curr Opin Immunol 2013; 25:200–5; PMID:23422836; http://dx.doi.org/10.1016/j.coi.2013.01.006
    • (2013) Curr Opin Immunol , vol.25 , pp. 200-205
    • Vonderheide, R.H.1    Bayne, L.J.2
  • 5
    • 84886780808 scopus 로고    scopus 로고
    • Activated pancreatic stellate cells sequester CD8 +T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma
    • PMID:23891972;
    • A.Ene-Obong, A.J.Clear, J.Watt, J.Wang, R.Fatah, J.C.Riches, J.F.Marshall, J.Chin-Aleong, C.Chelala, J.G.Gribben Activated pancreatic stellate cells sequester CD8 +T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma. Gastroenterology 2013; 145:1121–32; PMID:23891972; http://dx.doi.org/10.1053/j.gastro.2013.07.025
    • (2013) Gastroenterology , vol.145 , pp. 1121-1132
    • Ene-Obong, A.1    Clear, A.J.2    Watt, J.3    Wang, J.4    Fatah, R.5    Riches, J.C.6    Marshall, J.F.7    Chin-Aleong, J.8    Chelala, C.9    Gribben, J.G.10
  • 6
    • 79953154967 scopus 로고    scopus 로고
    • CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
    • PMID:21436454;
    • G.L.Beatty, E.G.Chiorean, M.P.Fishman, B.Saboury, U.R.Teitelbaum, W.Sun, R.D.Huhn, W.Song, D.Li, L.L.Sharp CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 2011; 331:1612–6; PMID:21436454; http://dx.doi.org/10.1126/science.1198443
    • (2011) Science , vol.331 , pp. 1612-1616
    • Beatty, G.L.1    Chiorean, E.G.2    Fishman, M.P.3    Saboury, B.4    Teitelbaum, U.R.5    Sun, W.6    Huhn, R.D.7    Song, W.8    Li, D.9    Sharp, L.L.10
  • 7
    • 20344407571 scopus 로고    scopus 로고
    • Immunotherapy for pancreatic cancer - science driving clinical progress
    • PMID:15905855;
    • D.Laheru, E.M.Jaffee. Immunotherapy for pancreatic cancer - science driving clinical progress. Nat Rev Cancer 2005; 5:459–67; PMID:15905855; http://dx.doi.org/10.1038/nrc1630
    • (2005) Nat Rev Cancer , vol.5 , pp. 459-467
    • Laheru, D.1    Jaffee, E.M.2
  • 8
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • PMID:24856586;
    • B.C.Ozdemir, T.Pentcheva-Hoang, J.L.Carstens, X.Zheng, C.C.Wu, T.R.Simpson, H.Laklai, H.Sugimoto, C.Kahlert, S.V.Novitskiy Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 2014; 25:719–34; PMID:24856586; http://dx.doi.org/10.1016/j.ccr.2014.04.005
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3    Zheng, X.4    Wu, C.C.5    Simpson, T.R.6    Laklai, H.7    Sugimoto, H.8    Kahlert, C.9    Novitskiy, S.V.10
  • 9
    • 82555191051 scopus 로고    scopus 로고
    • Cancer immunology–analysis of host and tumor factors for personalized medicine
    • PMID:21826083;
    • S.Ogino, J.Galon, C.S.Fuchs, G.Dranoff. Cancer immunology–analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol 2011; 8:711–9; PMID:21826083; http://dx.doi.org/10.1038/nrclinonc.2011.122
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 711-719
    • Ogino, S.1    Galon, J.2    Fuchs, C.S.3    Dranoff, G.4
  • 10
    • 84880704621 scopus 로고    scopus 로고
    • The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures
    • PMID:23890060;
    • J.Galon, H.K.Angell, D.Bedognetti, F.M.Marincola. The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures. Immunity 2013; 39:11–26; PMID:23890060; http://dx.doi.org/10.1016/j.immuni.2013.07.008
    • (2013) Immunity , vol.39 , pp. 11-26
    • Galon, J.1    Angell, H.K.2    Bedognetti, D.3    Marincola, F.M.4
  • 12
    • 84896957921 scopus 로고    scopus 로고
    • Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers
    • PMID:24523438;
    • Di G.Caro, F.Bergomas, F.Grizzi, A.Doni, P.Bianchi, A.Malesci, L.Laghi, P.Allavena, A.Mantovani, F.Marchesi. Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers. Clin Cancer Res 2014; 20:2147–58; PMID:24523438; http://dx.doi.org/10.1158/1078-0432.CCR-13-2590
    • (2014) Clin Cancer Res , vol.20 , pp. 2147-2158
    • Caro, G.1    Bergomas, F.2    Grizzi, F.3    Doni, A.4    Bianchi, P.5    Malesci, A.6    Laghi, L.7    Allavena, P.8    Mantovani, A.9    Marchesi, F.10
  • 13
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: impact on clinical outcome
    • PMID:22419253;
    • W.H.Fridman, F.Pages, C.Sautes-Fridman, J.Galon. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012; 12:298–306; PMID:22419253; http://dx.doi.org/10.1038/nrc3245
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3    Galon, J.4
  • 14
    • 70350225838 scopus 로고    scopus 로고
    • Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype
    • PMID:19825961;
    • S.Ogino, K.Nosho, N.Irahara, J.A.Meyerhardt, Y.Baba, K.Shima, J.N.Glickman, C.R.Ferrone, M.Mino-Kenudson, N.Tanaka Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. Clin Cancer Res 2009; 15:6412–20; PMID:19825961; http://dx.doi.org/10.1158/1078-0432.CCR-09-1438
    • (2009) Clin Cancer Res , vol.15 , pp. 6412-6420
    • Ogino, S.1    Nosho, K.2    Irahara, N.3    Meyerhardt, J.A.4    Baba, Y.5    Shima, K.6    Glickman, J.N.7    Ferrone, C.R.8    Mino-Kenudson, M.9    Tanaka, N.10
  • 16
    • 80052512017 scopus 로고    scopus 로고
    • Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling
    • PMID:21703392;
    • D.Coppola, M.Nebozhyn, F.Khalil, H.Dai, T.Yeatman, A.Loboda, J.J.Mule. Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling. Am J Pathol 2011; 179:37–45; PMID:21703392; http://dx.doi.org/10.1016/j.ajpath.2011.03.007
    • (2011) Am J Pathol , vol.179 , pp. 37-45
    • Coppola, D.1    Nebozhyn, M.2    Khalil, F.3    Dai, H.4    Yeatman, T.5    Loboda, A.6    Mule, J.J.7
  • 18
    • 84928559983 scopus 로고    scopus 로고
    • Tertiary lymphoid tissue in the tumor microenvironment: from its occurrence to immunotherapeutic implications
    • PMID:25901857;
    • G.Di Caro, G.F.Castino, F.Bergomas, N.Cortese, M.Chiriva-Internati, F.Grizzi, A.Mantovani, F.Marchesi. Tertiary lymphoid tissue in the tumor microenvironment: from its occurrence to immunotherapeutic implications. Int Rev Immunol 2015; 34:123–33; PMID:25901857; http://dx.doi.org/10.3109/08830185.2015.1018416
    • (2015) Int Rev Immunol , vol.34 , pp. 123-133
    • Di Caro, G.1    Castino, G.F.2    Bergomas, F.3    Cortese, N.4    Chiriva-Internati, M.5    Grizzi, F.6    Mantovani, A.7    Marchesi, F.8
  • 19
  • 21
    • 84923092072 scopus 로고    scopus 로고
    • Tertiary lymphoid structures in cancer and beyond
    • PMID:25443495;
    • M.C.Dieu-Nosjean, J.Goc, N.A.Giraldo, C.Sautes-Fridman, W.H.Fridman. Tertiary lymphoid structures in cancer and beyond. Trends Immunol 2014; 35(11):571–80; PMID:25443495; http://dx.doi.org/10.1016/j.it.2014.09.006
    • (2014) Trends Immunol , vol.35 , Issue.11 , pp. 571-580
    • Dieu-Nosjean, M.C.1    Goc, J.2    Giraldo, N.A.3    Sautes-Fridman, C.4    Fridman, W.H.5
  • 22
    • 84893851804 scopus 로고    scopus 로고
    • Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells
    • PMID:24366885;
    • J.Goc, C.Germain, T.K.Vo-Bourgais, A.Lupo, C.Klein, S.Knockaert, L.de Chaisemartin, H.Ouakrim, E.Becht, M.Alifano Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells. Cancer Res 2014; 74:705–15; PMID:24366885; http://dx.doi.org/10.1158/0008-5472.CAN-13-1342
    • (2014) Cancer Res , vol.74 , pp. 705-715
    • Goc, J.1    Germain, C.2    Vo-Bourgais, T.K.3    Lupo, A.4    Klein, C.5    Knockaert, S.6    de Chaisemartin, L.7    Ouakrim, H.8    Becht, E.9    Alifano, M.10
  • 23
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • PMID:15894262;
    • K.E.de Visser, L.V.Korets, L.M.Coussens. De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 2005; 7:411–23; PMID:15894262; http://dx.doi.org/10.1016/j.ccr.2005.04.014
    • (2005) Cancer Cell , vol.7 , pp. 411-423
    • de Visser, K.E.1    Korets, L.V.2    Coussens, L.M.3
  • 24
    • 78149488860 scopus 로고    scopus 로고
    • CD20+ B cells: the other tumor-infiltrating lymphocytes
    • PMID:20962266;
    • B.H.Nelson. CD20+ B cells: the other tumor-infiltrating lymphocytes. J Immunol 2010; 185:4977–82; PMID:20962266; http://dx.doi.org/10.4049/jimmunol.1001323
    • (2010) J Immunol , vol.185 , pp. 4977-4982
    • Nelson, B.H.1
  • 27
    • 77950070632 scopus 로고    scopus 로고
    • Effector and regulatory B cells: modulators of CD4+ T cell immunity
    • PMID:20224569;
    • F.E.Lund, T.D.Randall. Effector and regulatory B cells: modulators of CD4+ T cell immunity. Nat Rev Immunol 2010; 10:236–47; PMID:20224569; http://dx.doi.org/10.1038/nri2729
    • (2010) Nat Rev Immunol , vol.10 , pp. 236-247
    • Lund, F.E.1    Randall, T.D.2
  • 28
    • 84886943750 scopus 로고    scopus 로고
    • B cell-regulated immune responses in tumor models and cancer patients
    • PMID:24073382;
    • C.Fremd, F.Schuetz, C.Sohn, P.Beckhove, C.Domschke. B cell-regulated immune responses in tumor models and cancer patients. Oncoimmunology 2013; 2(7):e25443; PMID:24073382; http://dx.doi.org/10.4161/onci.25443
    • (2013) Oncoimmunology , vol.2 , Issue.7 , pp. e25443
    • Fremd, C.1    Schuetz, F.2    Sohn, C.3    Beckhove, P.4    Domschke, C.5
  • 32
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • PMID:11104798;
    • P.Schaerli, K.Willimann, A.B.Lang, M.Lipp, P.Loetscher, B.Moser. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000; 192:1553–62; PMID:11104798; http://dx.doi.org/10.1084/jem.192.11.1553
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 33
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • PMID:11104797;
    • D.Breitfeld, L.Ohl, E.Kremmer, J.Ellwart, F.Sallusto, M.Lipp, R.Forster. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000; 192:1545–52; PMID:11104797; http://dx.doi.org/10.1084/jem.192.11.1545
    • (2000) J Exp Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6    Forster, R.7
  • 34
    • 77952557954 scopus 로고    scopus 로고
    • PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
    • PMID:20453843;
    • K.L.Good-Jacobson, C.G.Szumilas, L.Chen, A.H.Sharpe, M.M.Tomayko, M.J.Shlomchik. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol 2010; 11:535–42; PMID:20453843; http://dx.doi.org/10.1038/ni.1877
    • (2010) Nat Immunol , vol.11 , pp. 535-542
    • Good-Jacobson, K.L.1    Szumilas, C.G.2    Chen, L.3    Sharpe, A.H.4    Tomayko, M.M.5    Shlomchik, M.J.6
  • 36
    • 84876475880 scopus 로고    scopus 로고
    • Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer
    • PMID:23333712;
    • P.Cappello, S.Rolla, R.Chiarle, M.Principe, F.Cavallo, G.Perconti, S.Feo, M.Giovarelli, F.Novelli. Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer. Gastroenterology 2013; 144:1098–106; PMID:23333712; http://dx.doi.org/10.1053/j.gastro.2013.01.020
    • (2013) Gastroenterology , vol.144 , pp. 1098-1106
    • Cappello, P.1    Rolla, S.2    Chiarle, R.3    Principe, M.4    Cavallo, F.5    Perconti, G.6    Feo, S.7    Giovarelli, M.8    Novelli, F.9
  • 37
    • 84879604267 scopus 로고    scopus 로고
    • B cells and their mediators as targets for therapy in solid tumors
    • PMID:23499742
    • A.J.Gunderson, L.M.Coussens. B cells and their mediators as targets for therapy in solid tumors. Exp Cell Res 2013; 319(11):1644–9; PMID:23499742; http://dx.doi.org/10.1016/j.yexcr.2013.03.005
    • (2013) Exp Cell Res , vol.319 , Issue.11 , pp. 1644-1649
    • Gunderson, A.J.1    Coussens, L.M.2
  • 38
    • 79953059789 scopus 로고    scopus 로고
    • Natural innate and adaptive immunity to cancer
    • PMID:21219185;
    • M.D.Vesely, M.H.Kershaw, R.D.Schreiber, M.J.Smyth. Natural innate and adaptive immunity to cancer. Annu Rev Immunol 2011; 29:235–71; PMID:21219185; http://dx.doi.org/10.1146/annurev-immunol-031210-101324
    • (2011) Annu Rev Immunol , vol.29 , pp. 235-271
    • Vesely, M.D.1    Kershaw, M.H.2    Schreiber, R.D.3    Smyth, M.J.4
  • 39
    • 0033988580 scopus 로고    scopus 로고
    • B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion
    • PMID:10630306;
    • E.Barbera-Guillem, M.B.Nelson, B.Barr, J.K.Nyhus, May KFJ, L.Feng, J.W.Sampsel. B lymphocyte pathology in human colorectal cancer. Experimental and clinical therapeutic effects of partial B cell depletion. Cancer Immunol Immunother 2000; 48:541–9; PMID:10630306; http://dx.doi.org/10.1007/PL00006672
    • (2000) Cancer Immunol Immunother , vol.48 , pp. 541-549
    • Barbera-Guillem, E.1    Nelson, M.B.2    Barr, B.3    Nyhus, J.K.4    Feng, L.5    Sampsel, J.W.6
  • 40
    • 4143138507 scopus 로고    scopus 로고
    • Depletion of normal B cells with rituximab as an adjunct to IL-2 therapy for renal cell carcinoma and melanoma
    • PMID:15205206;
    • M.Aklilu, W.M.Stadler, M.Markiewicz, N.J.Vogelzang, M.Mahowald, M.Johnson, T.F.Gajewski. Depletion of normal B cells with rituximab as an adjunct to IL-2 therapy for renal cell carcinoma and melanoma. Ann Oncol 2004; 15:1109–14; PMID:15205206; http://dx.doi.org/10.1093/annonc/mdh280
    • (2004) Ann Oncol , vol.15 , pp. 1109-1114
    • Aklilu, M.1    Stadler, W.M.2    Markiewicz, M.3    Vogelzang, N.J.4    Mahowald, M.5    Johnson, M.6    Gajewski, T.F.7
  • 41
    • 33646198040 scopus 로고    scopus 로고
    • B cell immunobiology in disease: evolving concepts from the clinic
    • PMID:16551256;
    • F.Martin, A.C.Chan. B cell immunobiology in disease: evolving concepts from the clinic. Annu Rev Immunol 2006; 24:467–96; PMID:16551256; http://dx.doi.org/10.1146/annurev.immunol.24.021605.090517
    • (2006) Annu Rev Immunol , vol.24 , pp. 467-496
    • Martin, F.1    Chan, A.C.2
  • 43
    • 84893711428 scopus 로고    scopus 로고
    • Tolerance and exhaustion: defining mechanisms of T cell dysfunction
    • PMID:24210163
    • A.Schietinger, P.D.Greenberg. Tolerance and exhaustion: defining mechanisms of T cell dysfunction. Trends Immunol 2014; 35(2):51–60; PMID:24210163; http://dx.doi.org/10.1016/j.it.2013.10.001
    • (2014) Trends Immunol , vol.35 , Issue.2 , pp. 51-60
    • Schietinger, A.1    Greenberg, P.D.2
  • 44
    • 84859158384 scopus 로고    scopus 로고
    • Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
    • PMID:22236695;
    • S.L.Topalian, C.G.Drake, D.M.Pardoll. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 2012; 24:207–12; PMID:22236695; http://dx.doi.org/10.1016/j.coi.2011.12.009
    • (2012) Curr Opin Immunol , vol.24 , pp. 207-212
    • Topalian, S.L.1    Drake, C.G.2    Pardoll, D.M.3
  • 46
    • 84886698315 scopus 로고    scopus 로고
    • Innate and adaptive immune cells in the tumor microenvironment
    • PMID:24048123;
    • T.F.Gajewski, H.Schreiber, Y.X.Fu. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol 2013; 14:1014–22; PMID:24048123; http://dx.doi.org/10.1038/ni.2703
    • (2013) Nat Immunol , vol.14 , pp. 1014-1022
    • Gajewski, T.F.1    Schreiber, H.2    Fu, Y.X.3
  • 47
    • 84964314430 scopus 로고    scopus 로고
    • Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation
    • PMID:24942756;
    • E.R.Lutz, A.A.Wu, E.Bigelow, R.Sharma, G.Mo, K.Soares, S.Solt, A.Dorman, A.Wamwea, A.Yager Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation. Cancer Immunol Res 2014; 2:616–31; PMID:24942756; http://dx.doi.org/10.1158/2326-6066.CIR-14-0027
    • (2014) Cancer Immunol Res , vol.2 , pp. 616-631
    • Lutz, E.R.1    Wu, A.A.2    Bigelow, E.3    Sharma, R.4    Mo, G.5    Soares, K.6    Solt, S.7    Dorman, A.8    Wamwea, A.9    Yager, A.10
  • 48
    • 84868277668 scopus 로고    scopus 로고
    • Twelve-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy
    • PMID:23097687;
    • J.L.Messina, D.A.Fenstermacher, S.Eschrich, X.Qu, A.E.Berglund, M.C.Lloyd, M.J.Schell, V.K.Sondak, J.S.Weber, J.J.Mule. Twelve-Chemokine gene signature identifies lymph node-like structures in melanoma: potential for patient selection for immunotherapy? Sci Rep 2012; 2:765; PMID:23097687; http://dx.doi.org/10.1038/srep00765
    • (2012) Sci Rep , vol.2 , pp. 765
    • Messina, J.L.1    Fenstermacher, D.A.2    Eschrich, S.3    Qu, X.4    Berglund, A.E.5    Lloyd, M.C.6    Schell, M.J.7    Sondak, V.K.8    Weber, J.S.9    Mule, J.J.10
  • 50
    • 84928226005 scopus 로고    scopus 로고
    • The interaction of anticancer therapies with tumor-associated macrophages
    • PMID:25753580;
    • A.Mantovani, P.Allavena. The interaction of anticancer therapies with tumor-associated macrophages. J Exp Med 2015; 212(4):435–45; PMID:25753580; http://dx.doi.org/10.1084/jem.20150295
    • (2015) J Exp Med , vol.212 , Issue.4 , pp. 435-445
    • Mantovani, A.1    Allavena, P.2
  • 51
    • 84861543054 scopus 로고    scopus 로고
    • Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration
    • PMID:22675273;
    • D.G.Altman, L.M.McShane, W.Sauerbrei, S.E.Taube. Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration. PLoS Med 2012; 9:e1001216; PMID:22675273; http://dx.doi.org/10.1371/journal.pmed.1001216
    • (2012) PLoS Med , vol.9 , pp. e1001216
    • Altman, D.G.1    McShane, L.M.2    Sauerbrei, W.3    Taube, S.E.4
  • 52
    • 0032441150 scopus 로고    scopus 로고
    • Cluster analysis and display of genome-wide expression patterns
    • PMID:9843981;
    • M.B.Eisen, P.T.Spellman, P.O.Brown, D.Botstein. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A 1998; 95:14863–8; PMID:9843981; http://dx.doi.org/10.1073/pnas.95.25.14863
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14863-14868
    • Eisen, M.B.1    Spellman, P.T.2    Brown, P.O.3    Botstein, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.