Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity

Science

Volumn 353, Issue 6297, 2016, Pages 399-403

  Dorand, R Dixon ^a   Nthale, Joseph ^a,b   Myers, Jay T ^a,b   Barkauskas, Deborah S ^a,b   Avril, Stefanie ^a   Chirieleison, Steven M ^a   Pareek, Tej K ^a,b   Abbott, Derek W ^a   Stearns, Duncan S ^a,b   Letterio, John J ^a,b   Huang, Alex Y ^a,b   Petrosiute, Agne ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CYCLIN DEPENDENT KINASE 5; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR 2; IRF2BP2 PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG; CD274 PROTEIN, MOUSE; CDK5 PROTEIN, MOUSE; IRF2 PROTEIN, MOUSE; IRF2BP2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

CELLS AND CELL COMPONENTS; IMMUNITY; INHIBITION; LIGAND; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; IMMUNOLOGICAL MEMORY; LYMPHOCYTIC INFILTRATION; MEDULLOBLASTOMA; MICROGLIA; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; TRANSCRIPTION REGULATION; TUMOR IMMUNITY; UPREGULATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CEREBELLUM TUMOR; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; IMMUNOSURVEILLANCE; MALE; METABOLISM; NUDE MOUSE; PHYSIOLOGY; TUMOR CELL LINE; TUMOR ESCAPE;

ANIMALS; ANTIGENS, CD274; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CEREBELLAR NEOPLASMS; CYCLIN-DEPENDENT KINASE 5; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOLOGIC SURVEILLANCE; INTERFERON REGULATORY FACTOR-2; MALE; MEDULLOBLASTOMA; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; TRANSCRIPTION FACTORS; TUMOR ESCAPE;

EID: 84979502955     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aae0477     Document Type: Article

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