-
1
-
-
84927531186
-
Long-term efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001
-
(suppl; abstr 9005), 25605849
-
A.Daud, A.Ribas, C.Robert, S.Hodi, J.D.Wolchok, A.M.Joshua, W.-J.Hwu, et al. Long-term efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001. J Clin Oncol 2015; 33 (suppl; abstr 9005); PMID:25605849; http://dx.doi.org/10.1200/JCO.2014.57.5027
-
(2015)
J Clin Oncol
, vol.33
-
-
Daud, A.1
Ribas, A.2
Robert, C.3
Hodi, S.4
Wolchok, J.D.5
Joshua, A.M.6
Hwu, W.-J.7
-
2
-
-
84937513626
-
A phase III study (CheckMate 017) of nivolumab (NIVO; anti-programmed death-1 [PD-1]) vs. docetaxel (DOC) in previously treated advanced or metastatic squamous (SQ) cell non-small cell lung cancer (NSCLC)
-
(suppl; abstr 8009), 25897158
-
D.R.Spigel, K.L.Reckamp, N.A.Rizvi, E.Poddubskaya, H.J.West, W.E.E.Eberhardt, P.Baas, S.J.Antonia, A.Pluzanski, E.E.Vokes, et al. A phase III study (CheckMate 017) of nivolumab (NIVO; anti-programmed death-1 [PD-1]) vs. docetaxel (DOC) in previously treated advanced or metastatic squamous (SQ) cell non-small cell lung cancer (NSCLC). J Clin Oncol 2015; 33 (suppl; abstr 8009); PMID:25897158
-
(2015)
J Clin Oncol
, vol.33
-
-
Spigel, D.R.1
Reckamp, K.L.2
Rizvi, N.A.3
Poddubskaya, E.4
West, H.J.5
Eberhardt, W.E.E.6
Baas, P.7
Antonia, S.J.8
Pluzanski, A.9
Vokes, E.E.10
-
3
-
-
84936791837
-
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer
-
26028407
-
J.Brahmer, K.L.Reckamp, P.Baas, L.Crino, W.E.Eberhardt, E.Poddubskaya, S.Antonia, A.Pluzanski, E.E.Vokes, E.Holgado, et al. Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer. N Engl J Med 2015; 373(2):123-35; PMID:26028407
-
(2015)
N Engl J Med
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
Crino, L.4
Eberhardt, W.E.5
Poddubskaya, E.6
Antonia, S.7
Pluzanski, A.8
Vokes, E.E.9
Holgado, E.10
-
4
-
-
84931424042
-
Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non-SQ) non-small cell lung cancer (NSCLC)
-
(suppl; abstr LBA109)
-
L.Paz-Ares, L.Horn, H.Borghaei, D.R.Spigel, M.Steins, N.Ready, L.Chow, E.E.Vokes, E.Felip, E.Holgado, et al. Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non-SQ) non-small cell lung cancer (NSCLC). J Clin Oncol 2015; 33 (suppl; abstr LBA109).
-
(2015)
J Clin Oncol
, vol.33
-
-
Paz-Ares, L.1
Horn, L.2
Borghaei, H.3
Spigel, D.R.4
Steins, M.5
Ready, N.6
Chow, L.7
Vokes, E.E.8
Felip, E.9
Holgado, E.10
-
5
-
-
84944714731
-
Clinical activity, safety and predictive biomarkers of the engineered antibody MPDL3280A (anti-PDL1) in non-small cell lung cancer (NSCLC): update from a phase Ia study
-
(suppl; abstr 8029), 25897158
-
L.Horn, D.R.Spigel, S.Gettinger, S.Antonia, M.S.Gordon, R.S.Herbst, L.V.Sequist, C.Chappey, M.Kowanetz, A.Sandler, et al. Clinical activity, safety and predictive biomarkers of the engineered antibody MPDL3280A (anti-PDL1) in non-small cell lung cancer (NSCLC): update from a phase Ia study. J Clin Oncol 2015; 33 (suppl; abstr 8029); PMID:25897158
-
(2015)
J Clin Oncol
, vol.33
-
-
Horn, L.1
Spigel, D.R.2
Gettinger, S.3
Antonia, S.4
Gordon, M.S.5
Herbst, R.S.6
Sequist, L.V.7
Chappey, C.8
Kowanetz, M.9
Sandler, A.10
-
6
-
-
84947444410
-
Clinical activity and safety from a phase II study (FIR) of MPDL3280A (anti-PDL1) in PD-L1–selected patients with non-small cell lung cancer (NSCLC)
-
(suppl; abstr 8028), 25897158
-
D.R.Spigel, K.L.Reckamp, S.Gettinger, B.Chao, L.Dirix, P.Schmid, L.Q.Chow, C.Chappey, M.Kowanetz, A.Sandler, et al. Clinical activity and safety from a phase II study (FIR) of MPDL3280A (anti-PDL1) in PD-L1–selected patients with non-small cell lung cancer (NSCLC). J Clin Oncol 2015; 33 (suppl; abstr 8028); PMID:25897158
-
(2015)
J Clin Oncol
, vol.33
-
-
Spigel, D.R.1
Reckamp, K.L.2
Gettinger, S.3
Chao, B.4
Dirix, L.5
Schmid, P.6
Chow, L.Q.7
Chappey, C.8
Kowanetz, M.9
Sandler, A.10
-
7
-
-
84940606077
-
Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): preliminary results from KEYNOTE-012 expansion cohort
-
(suppl; abstr LBA6008), 25667282
-
T.Y.Seiwert, R.I.Haddad, S.Gupta, R.Mehra, M.Tahara, R.Berger, S.Lee, B.Burtness, D.T.Le, K.Heath, et al. Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): preliminary results from KEYNOTE-012 expansion cohort. J Clin Oncol 2015; 33 (suppl; abstr LBA6008); PMID:25667282
-
(2015)
J Clin Oncol
, vol.33
-
-
Seiwert, T.Y.1
Haddad, R.I.2
Gupta, S.3
Mehra, R.4
Tahara, M.5
Berger, R.6
Lee, S.7
Burtness, B.8
Le, D.T.9
Heath, K.10
-
8
-
-
84937690774
-
Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with previously treated, recurrent or refractory ovarian cancer: A phase Ib, open-label expansion trial
-
(suppl; abstr 5509), 25918278
-
M.L.Disis, M.R.Patel, S.Pant, J.R.Infante, C.Lockhart, K.Kelly, J.T.Beck, M.S.Gordon, G.Weiss, S.Ejadi, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with previously treated, recurrent or refractory ovarian cancer: A phase Ib, open-label expansion trial. J Clin Oncol 2015; 33 (suppl; abstr 5509); PMID:25918278
-
(2015)
J Clin Oncol
, vol.33
-
-
Disis, M.L.1
Patel, M.R.2
Pant, S.3
Infante, J.R.4
Lockhart, C.5
Kelly, K.6
Beck, J.T.7
Gordon, M.S.8
Weiss, G.9
Ejadi, S.10
-
9
-
-
84937721776
-
Antitumor activity and safety of pembrolizumab in patients (pts) with PD-L1 positive advanced ovarian cancer: Interim results from a phase Ib study
-
(suppl; abstr 5510)
-
A.Varga, S.A.Piha-Paul, P.A.Ott, J.M.Mehnert, D.Berton-Rigaud, E.A.Johnson, J.D.Cheng, S.Yuan, et al. Antitumor activity and safety of pembrolizumab in patients (pts) with PD-L1 positive advanced ovarian cancer: Interim results from a phase Ib study. J Clin Oncol 2015; 33 (suppl; abstr 5510).
-
(2015)
J Clin Oncol
, vol.33
-
-
Varga, A.1
Piha-Paul, S.A.2
Ott, P.A.3
Mehnert, J.M.4
Berton-Rigaud, D.5
Johnson, E.A.6
Cheng, J.D.7
Yuan, S.8
-
10
-
-
84939548996
-
Mehnert. Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): preliminary safety and efficacy results from KEYNOTE-028
-
(suppl; abstr 7502)
-
P.A.Ott, M.E.E.Fernadez, S.Hiret, D.-W.Kim, R.A.Moss, T.Winser, S.Yuan, J.D.Cheng, B.Piperdi, M.Janice. Mehnert. Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): preliminary safety and efficacy results from KEYNOTE-028. J Clin Oncol 2015; 33 (suppl; abstr 7502).
-
(2015)
J Clin Oncol
, vol.33
-
-
Ott, P.A.1
Fernadez, M.E.E.2
Hiret, S.3
Kim, D.-W.4
Moss, R.A.5
Winser, T.6
Yuan, S.7
Cheng, J.D.8
Piperdi, B.9
Janice, M.10
-
11
-
-
84937067787
-
Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040
-
(suppl; abstr LBA101)
-
A.B.El-Khoueiry, I.Melero, T.S.Crocenzi, T.H.Welling, T.H.Yau, W.Yeo, A.Chopra, J.Grosso, L.Lang, J.Anderson, et al. Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040. J Clin Oncol 2015; 33 (suppl; abstr LBA101).
-
(2015)
J Clin Oncol
, vol.33
-
-
El-Khoueiry, A.B.1
Melero, I.2
Crocenzi, T.S.3
Welling, T.H.4
Yau, T.H.5
Yeo, W.6
Chopra, A.7
Grosso, J.8
Lang, L.9
Anderson, J.10
-
12
-
-
84961573218
-
Pembrolizumab (MK-3475) for patients (pts) with advanced esophageal carcinoma: preliminary results from KEYNOTE-028
-
(suppl; abstr 4010)
-
D.Toshihikod, S.A.Piha-Paul, S.I.Jalal, H.Mai-Dang, S.Yuan, M.Koshiji, I.Csiki, J.Bennouna. Pembrolizumab (MK-3475) for patients (pts) with advanced esophageal carcinoma: preliminary results from KEYNOTE-028. J Clin Oncol 2015; 33 (suppl; abstr 4010).
-
(2015)
J Clin Oncol
, vol.33
-
-
Toshihiko, D.1
Piha-Paul, S.A.2
Jalal, S.I.3
Mai-Dang, H.4
Yuan, S.5
Koshiji, M.6
Csiki, I.7
Bennouna, J.8
-
13
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
25409260
-
A.Snyder, V.Makarov, T.Merghoub, J.Yuan, J.M.Zaretsky, A.Desrichard, L.A.Walsh, M.A.Postow, P.Wong, T.S.Ho, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 2014; 371:2189-99; PMID:25409260; http://dx.doi.org/10.1056/NEJMoa1406498
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
Yuan, J.4
Zaretsky, J.M.5
Desrichard, A.6
Walsh, L.A.7
Postow, M.A.8
Wong, P.9
Ho, T.S.10
-
14
-
-
84920962202
-
Molecular and genetic properties of tumors associated with local immune cytolytic activity
-
25594174
-
M.S.Rooney, S.A.Shukla, C.J.Wu, G.Getz, N.Hacohen. Molecular and genetic properties of tumors associated with local immune cytolytic activity. Cell 2015; 160:48-61; PMID:25594174; http://dx.doi.org/10.1016/j.cell.2014.12.033
-
(2015)
Cell
, vol.160
, pp. 48-61
-
-
Rooney, M.S.1
Shukla, S.A.2
Wu, C.J.3
Getz, G.4
Hacohen, N.5
-
15
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
25765070
-
N.A.Rizvi, M.D.Hellmann, A.Snyder, P.Kvistborg, V.Makarov, J.J.Havel, W.Lee, J.Yuan, P.Wong, T.S.Ho, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015; 348:124-8; PMID:25765070; http://dx.doi.org/10.1126/science.aaa1348
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
Lee, W.7
Yuan, J.8
Wong, P.9
Ho, T.S.10
-
16
-
-
84929431322
-
PD-1 blockade in tumors with mismatch repair deficiency
-
(suppl; abstr LBA100)
-
D.T.Le, J.N.Uram, H.Wang, B.Bartlett, H.Kemberling, A.Eyring, A.Skora, N.S.Azad, N.A.Laheru, R.C.Donehower, et al. PD-1 blockade in tumors with mismatch repair deficiency. J Clin Oncol 2015; 33 (suppl; abstr LBA100); http://dx.doi.org/10.1200/JCO.2014.57.4244
-
(2015)
J Clin Oncol
, vol.33
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.4
Kemberling, H.5
Eyring, A.6
Skora, A.7
Azad, N.S.8
Laheru, N.A.9
Donehower, R.C.10
-
17
-
-
84932628341
-
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
-
26028255
-
D.T.Le, J.N.Uram, H.Wang, B.R.Bartlett, H.Kemberling, A.D.Eyring, A.D.Skora, B.S.Luber, N.S.Azad, D.Laheru, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med 2015; 372:2509-20; PMID:26028255; http://dx.doi.org/10.1056/NEJMoa1500596
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
Bartlett, B.R.4
Kemberling, H.5
Eyring, A.D.6
Skora, A.D.7
Luber, B.S.8
Azad, N.S.9
Laheru, D.10
-
18
-
-
84937129359
-
Safety and efficacy of MPDL3280A (anti-PDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC)
-
(suppl; abstr 8030)
-
S.V.Liu, J.D.Powderly, R.Camidge, N.Ready, R.S.Heist, F.S.Hodi, G.Giaccone, B.Liu, J.Wallin, R.P.Funke, et al. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2015; 33 (suppl; abstr 8030); http://dx.doi.org/10.1200/JCO.2014.57.7999
-
(2015)
J Clin Oncol
, vol.33
-
-
Liu, S.V.1
Powderly, J.D.2
Camidge, R.3
Ready, N.4
Heist, R.S.5
Hodi, F.S.6
Giaccone, G.7
Liu, B.8
Wallin, J.9
Funke, R.P.10
-
19
-
-
84947444749
-
Pembrolizumab (pembro; MK-3475) plus platinum doublet chemotherapy (PDC) as front-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 Cohorts A and C
-
(suppl; abstr 8031)
-
V.Papadimitrakopoulou, A.Patnaik, H.Borghaei, J.Stevenson, L.Gandhi, M.A.Gubens, J.C.H.Yang, L.V.Sequist, L.G.Ge, J.Bourque. Pembrolizumab (pembro; MK-3475) plus platinum doublet chemotherapy (PDC) as front-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 Cohorts A and C. J Clin Oncol 2015; 33 (suppl; abstr 8031).
-
(2015)
J Clin Oncol
, vol.33
-
-
Papadimitrakopoulou, V.1
Patnaik, A.2
Borghaei, H.3
Stevenson, J.4
Gandhi, L.5
Gubens, M.A.6
Yang, J.C.H.7
Sequist, L.V.8
Ge, L.G.9
Bourque, J.10
-
20
-
-
84942138310
-
Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D
-
(suppl; abstr 8011)
-
A.Patnaik, M.A.Socinski, M.A.Gubens, L.Gandhi, J.Stevenson, R.D.Bachman, J.B.Bourque, J.Y.Ge, E.Im, S.M.Gadgeel. Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J Clin Oncol 2015; 33 (suppl; abstr 8011).
-
(2015)
J Clin Oncol
, vol.33
-
-
Patnaik, A.1
Socinski, M.A.2
Gubens, M.A.3
Gandhi, L.4
Stevenson, J.5
Bachman, R.D.6
Bourque, J.B.7
Ge, J.Y.8
Im, E.9
Gadgeel, S.M.10
-
21
-
-
84939518267
-
Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032
-
2015 (suppl; abstr 7503), 25897158
-
S.J.Antonia, M.H.Taylor, E.Calvo, D.Jaeger, F.G.De Braud, P.A.Ott, M.C.Pietanza, L.Horn, D.T.Le, M.Morse. Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032. J Clin Oncol 2015; 33, 2015 (suppl; abstr 7503); PMID:25897158
-
(2015)
J Clin Oncol
, vol.33
-
-
Antonia, S.J.1
Taylor, M.H.2
Calvo, E.3
Jaeger, D.4
De Braud, F.G.5
Ott, P.A.6
Pietanza, M.C.7
Horn, L.8
Le, D.T.9
Morse, M.10
-
22
-
-
84936821506
-
Survival, safety, and response patterns in a phase 1b multicenter trial of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma
-
(suppl; abstr 9063), 25800770
-
I.Puzanov, M.M.Milhem, R.H.I.Andtbacka, D.R.Minor, O.Hamid, A.Li, J.Chou, H.Kaufman. Survival, safety, and response patterns in a phase 1b multicenter trial of talimogene laherparepvec (T-VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB-IV melanoma. J Clin Oncol 2015; 33 (suppl; abstr 9063); PMID:25800770
-
(2015)
J Clin Oncol
, vol.33
-
-
Puzanov, I.1
Milhem, M.M.2
Andtbacka, R.H.I.3
Minor, D.R.4
Hamid, O.5
Li, A.6
Chou, J.7
Kaufman, H.8
-
23
-
-
84962859480
-
A phase I study of intratumoral injection of ipilimumab and interleukin-2 in patients with unresectable stage III-IV melanoma
-
(suppl; abstr 3018), 25366685
-
R.C.Bowen, S.Meek, M.Williams, K.F.Grossmann, R.Andtbacka, T.L.Bowles, J.R.Hyngstrom, S.A.Leachman, D.Grossman, S.L.Holmen, et al. A phase I study of intratumoral injection of ipilimumab and interleukin-2 in patients with unresectable stage III-IV melanoma. J Clin Oncol 33 (suppl; abstr 3018); PMID:25366685
-
J Clin Oncol
, vol.33
-
-
Bowen, R.C.1
Meek, S.2
Williams, M.3
Grossmann, K.F.4
Andtbacka, R.5
Bowles, T.L.6
Hyngstrom, J.R.7
Leachman, S.A.8
Grossman, D.9
Holmen, S.L.10
-
24
-
-
84958803062
-
Safety of pembrolizumab (pem) in patients (pts) who stopped ipilimumab (ipi) due to immune-related adverse events
-
(suppl; abstr e20023)
-
A.N.Shoushtari, M.A.Postow, T.Z.Horvat, N.G.Adel, T.Dang, P.B.Chapman. Safety of pembrolizumab (pem) in patients (pts) who stopped ipilimumab (ipi) due to immune-related adverse events. J Clin Oncol 2015; 33 (suppl; abstr e20023).
-
(2015)
J Clin Oncol
, vol.33
-
-
Shoushtari, A.N.1
Postow, M.A.2
Horvat, T.Z.3
Adel, N.G.4
Dang, T.5
Chapman, P.B.6
-
25
-
-
84961596355
-
Efficacy and toxicity of treatment with the anti-CTLA-4 antibody Ipilimumab in patients with metastatic melanoma who have progressed on anti-PD-1 therapy
-
(suppl; abstr 9059)
-
P.Prithviraj, G.A.McArthur, V.Atkinson, P.Parente, M.C.Andrews, S.Parakh, J.S.Cebon, O.Klein. Efficacy and toxicity of treatment with the anti-CTLA-4 antibody Ipilimumab in patients with metastatic melanoma who have progressed on anti-PD-1 therapy. J Clin Oncol 2015; 33 (suppl; abstr 9059).
-
(2015)
J Clin Oncol
, vol.33
-
-
Prithviraj, P.1
McArthur, G.A.2
Atkinson, V.3
Parente, P.4
Andrews, M.C.5
Parakh, S.6
Cebon, J.S.7
Klein, O.8
-
26
-
-
84955326912
-
The use of pembrolizumab for the treatment of metastatic uveal melanoma
-
(suppl; abstr 9010)
-
L.A.Kottschade, R.R.McWilliams, S.Markovic, M.S.Block, J.S.Bisneto, A.Q.Pham, R.S.Dronca. The use of pembrolizumab for the treatment of metastatic uveal melanoma. J Clin Oncol 2015; 33 (suppl; abstr 9010).
-
(2015)
J Clin Oncol
, vol.33
-
-
Kottschade, L.A.1
McWilliams, R.R.2
Markovic, S.3
Block, M.S.4
Bisneto, J.S.5
Pham, A.Q.6
Dronca, R.S.7
-
27
-
-
84961658812
-
Response to anti-PD1/PDL1 therapy in patients with metastatic desmoplastic melanoma
-
(suppl; abstr 9011)
-
Z.Eroglu, D.W.Kim, D.B.Johnson, A.P.Algazi, P.R.Munhoz, E.Liniker, B.Kong, N.Khurana, B.Chmielowski, J.A.Sosman et al. Response to anti-PD1/PDL1 therapy in patients with metastatic desmoplastic melanoma. J Clin Oncol 2015; 33 (suppl; abstr 9011).
-
(2015)
J Clin Oncol
, vol.33
-
-
Eroglu, Z.1
Kim, D.W.2
Johnson, D.B.3
Algazi, A.P.4
Munhoz, P.R.5
Liniker, E.6
Kong, B.7
Khurana, N.8
Chmielowski, B.9
Sosman, J.A.10
|