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Volumn 71, Issue 21, 2011, Pages 6567-6571

Prospects for TIM3-targeted antitumor immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD11B ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; ECALECTIN; GAMMA INTERFERON; GENE PRODUCT; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR; PROGRAMMED DEATH 1 RECEPTOR MONOCLONAL ANTIBODY; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN 3; TIM3 MONOCLONAL ANTIBODY; TIM3 PROTEIN; UNCLASSIFIED DRUG;

EID: 80155127321     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-1487     Document Type: Review
Times cited : (108)

References (36)
  • 2
    • 65349083187 scopus 로고    scopus 로고
    • Negative regulators of T-cell activation: Potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
    • Pentcheva-Hoang T, Corse E, Allison JP. Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections. Immunol Rev 2009; 229:67-87.
    • (2009) Immunol Rev , vol.229 , pp. 67-87
    • Pentcheva-Hoang, T.1    Corse, E.2    Allison, J.P.3
  • 5
    • 49649114804 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger R, Rotem-Yehudar R, Slama G, Landes S, Kneller A, Leiba M, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 2008;14:3044-51.
    • (2008) Clin Cancer Res , vol.14 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3    Landes, S.4    Kneller, A.5    Leiba, M.6
  • 6
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX- 1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, et al. Phase I study of single-agent anti-programmed death-1 (MDX- 1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010;28:3167-75.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3    Powderly, J.D.4    Picus, J.5    Sharfman, W.H.6
  • 7
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 2009;206:1717-25.
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 8
    • 77952325212 scopus 로고    scopus 로고
    • Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals
    • Mitsui J, Nishikawa H, Muraoka D, Wang L, Noguchi T, Sato E, et al. Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. Clin Cancer Res 2010;16:2781-91.
    • (2010) Clin Cancer Res , vol.16 , pp. 2781-2791
    • Mitsui, J.1    Nishikawa, H.2    Muraoka, D.3    Wang, L.4    Noguchi, T.5    Sato, E.6
  • 9
    • 33646794392 scopus 로고    scopus 로고
    • Checkpoint Blockade in Cancer Immunotherapy
    • DOI 10.1016/S0065-2776(06)90008-X, PII S006527760690008X
    • Korman AJ, Peggs KS, Allison JP. Checkpoint blockade in cancer immunotherapy. Adv Immunol 2006;90:297-339. (Pubitemid 43765802)
    • (2006) Advances in Immunology , vol.90 , pp. 297-339
    • Korman, A.J.1    Peggs, K.S.2    Allison, J.P.3
  • 10
    • 78449243490 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy: Immune monitoring during clinical development of a novel immunotherapy
    • Callahan MK, Wolchok JD, Allison JP. Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy. Semin Oncol 2010;37:473-84.
    • (2010) Semin Oncol , vol.37 , pp. 473-484
    • Callahan, M.K.1    Wolchok, J.D.2    Allison, J.P.3
  • 11
    • 58749096691 scopus 로고    scopus 로고
    • The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation
    • Wolchok JD, Saenger Y. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. Oncologist 2008;13[Suppl 4]:2-9.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 4 , pp. 2-9
    • Wolchok, J.D.1    Saenger, Y.2
  • 13
    • 69749106159 scopus 로고    scopus 로고
    • PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells
    • Wang W, Lau R, Yu D, Zhu W, Korman A, Weber J. PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells. Int Immunol 2009;21:1065-77.
    • (2009) Int Immunol , vol.21 , pp. 1065-1077
    • Wang, W.1    Lau, R.2    Yu, D.3    Zhu, W.4    Korman, A.5    Weber, J.6
  • 14
    • 79952775415 scopus 로고    scopus 로고
    • Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer
    • Kline J, Gajewski TF. Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer. Curr Opin Investig Drugs 2010;11:1354-9.
    • (2010) Curr Opin Investig Drugs , vol.11 , pp. 1354-1359
    • Kline, J.1    Gajewski, T.F.2
  • 15
    • 76249090050 scopus 로고    scopus 로고
    • Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: Regulation and counterregulation
    • Currie AJ, Prosser A, McDonnell A, Cleaver AL, Robinson BW, Freeman GJ, et al. Dual control of antitumor CD8 T cells through the programmed death-1/programmed death-ligand 1 pathway and immunosuppressive CD4 T cells: regulation and counterregulation. J Immunol 2009;183:7898-908.
    • (2009) J Immunol , vol.183 , pp. 7898-7908
    • Currie, A.J.1    Prosser, A.2    McDonnell, A.3    Cleaver, A.L.4    Robinson, B.W.5    Freeman, G.J.6
  • 16
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A 2010;107:4275-80.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 18
    • 78651072784 scopus 로고    scopus 로고
    • Single dose of anti- CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance
    • Pedicord VA, Montalvo W, Leiner IM, Allison JP. Single dose of anti- CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance. Proc Natl Acad Sci U S A 2011;108:266-71.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 266-271
    • Pedicord, V.A.1    Montalvo, W.2    Leiner, I.M.3    Allison, J.P.4
  • 19
    • 2442585121 scopus 로고    scopus 로고
    • Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
    • Chen L. Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity. Nat Rev Immunol 2004;4:336-47. (Pubitemid 38649276)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.5 , pp. 336-347
    • Chen, L.1
  • 20
    • 77951673268 scopus 로고    scopus 로고
    • TIM genes: A family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
    • Freeman GJ, Casasnovas JM, Umetsu DT, DeKruyff RH. TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev 2010;235:172-89.
    • (2010) Immunol Rev , vol.235 , pp. 172-189
    • Freeman, G.J.1    Casasnovas, J.M.2    Umetsu, D.T.3    DeKruyff, R.H.4
  • 25
    • 65549168745 scopus 로고    scopus 로고
    • Tim-3 mediates phagocytosis of apoptotic cells and crosspresentation
    • Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, et al. Tim-3 mediates phagocytosis of apoptotic cells and crosspresentation. Blood 2009;113:3821-30.
    • (2009) Blood , vol.113 , pp. 3821-3830
    • Nakayama, M.1    Akiba, H.2    Takeda, K.3    Kojima, Y.4    Hashiguchi, M.5    Azuma, M.6
  • 26
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med 2010;207:2187-94.
    • (2010) J Exp Med , vol.207 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3    Blazar, B.R.4    Kuchroo, V.K.5    Anderson, A.C.6
  • 27
    • 77957723967 scopus 로고    scopus 로고
    • Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
    • Fourcade J, Sun Z, Benallaoua M, Guillaume P, Luescher IF, Sander C, et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J Exp Med 2010;207:2175-86.
    • (2010) J Exp Med , vol.207 , pp. 2175-2186
    • Fourcade, J.1    Sun, Z.2    Benallaoua, M.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6
  • 28
    • 79956103042 scopus 로고    scopus 로고
    • Anti-TIM3 antibody promotes T cell IFN-g-mediated antitumor immunity and suppresses established tumors
    • Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-g-mediated antitumor immunity and suppresses established tumors. Cancer Res 2011;71: 3540-51.
    • (2011) Cancer Res , vol.71 , pp. 3540-3551
    • Ngiow, S.F.1    Von Scheidt, B.2    Akiba, H.3    Yagita, H.4    Teng, M.W.5    Smyth, M.J.6
  • 29
    • 79955977180 scopus 로고    scopus 로고
    • Co-expression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
    • Zhou Q, Munger ME, Veenstra RG, Weigel BJ, Hirashima M, Munn DH, et al. Co-expression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood 2011;117:4501-10.
    • (2011) Blood , vol.117 , pp. 4501-4510
    • Zhou, Q.1    Munger, M.E.2    Veenstra, R.G.3    Weigel, B.J.4    Hirashima, M.5    Munn, D.H.6
  • 30
    • 77956409684 scopus 로고    scopus 로고
    • Tim-3/Galectin-9 pathway: Regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells
    • Dardalhon V, Anderson AC, Karman J, Apetoh L, Chandwaskar R, Lee DH, et al. Tim-3/Galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells. J Immunol 2010;185:1383-92.
    • (2010) J Immunol , vol.185 , pp. 1383-1392
    • Dardalhon, V.1    Anderson, A.C.2    Karman, J.3    Apetoh, L.4    Chandwaskar, R.5    Lee, D.H.6
  • 31
    • 71849095178 scopus 로고    scopus 로고
    • Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions
    • Nagahara K, Arikawa T, Oomizu S, Kontani K, Nobumoto A, Tateno H, et al. Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions. J Immunol 2008;181:7660-9.
    • (2008) J Immunol , vol.181 , pp. 7660-7669
    • Nagahara, K.1    Arikawa, T.2    Oomizu, S.3    Kontani, K.4    Nobumoto, A.5    Tateno, H.6
  • 33
    • 78049243425 scopus 로고    scopus 로고
    • Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth
    • Teng MW, Ngiow SF, von Scheidt B, McLaughlin N, Sparwasser T, Smyth MJ. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res 2010;70:7800-9.
    • (2010) Cancer Res , vol.70 , pp. 7800-7809
    • Teng, M.W.1    Ngiow, S.F.2    Von Scheidt, B.3    McLaughlin, N.4    Sparwasser, T.5    Smyth, M.J.6
  • 34
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • Matsuzaki J, Gnjatic S, Mhawech-Fauceglia P, Beck A, Miller A, Tsuji T, et al. Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci U S A 2010;107:7875-80.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7875-7880
    • Matsuzaki, J.1    Gnjatic, S.2    Mhawech-Fauceglia, P.3    Beck, A.4    Miller, A.5    Tsuji, T.6
  • 35
    • 79951684125 scopus 로고    scopus 로고
    • PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
    • Okazaki T, Okazaki IM, Wang J, Sugiura D, Nakaki F, Yoshida T, et al. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med 2011;208:395-407.
    • (2011) J Exp Med , vol.208 , pp. 395-407
    • Okazaki, T.1    Okazaki, I.M.2    Wang, J.3    Sugiura, D.4    Nakaki, F.5    Yoshida, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.